Patents Issued in November 6, 2018
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Patent number: 10119089Abstract: A continuous process and apparatus for treating dried coal and coal char to promote passivation of the reactive carbon particles by forming a protective oxide coating and simultaneously adding moisture to rehydrate said particles. The passivation process is conducted in a novel apparatus providing for the staged control of the reaction temperature and the staged introduction of both oxygen and moisture. The fluidized bed apparatus has internal in-bed cooling means embedded within the fluidized coal or coal char particles so as to remove the heat energy as it is released by virtue of the exothermic passivation reactions.Type: GrantFiled: May 6, 2015Date of Patent: November 6, 2018Assignee: C2O TECHNOLOGIES, LLCInventors: Franklin G. Rinker, Deane Avent Horne, Timothy J. Kuhn, Robert W. Mueller, James Darrell Kinder
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Patent number: 10119090Abstract: A method for preventing or reducing engine knock or pre-ignition in a high compression spark ignition engine lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition that contains (i) a lubricating oil base stock comprising at least one ester including at least one group selected from the group consisting of Formula (1), Formula (2), and Formula (3): The lubricating oils of this disclosure are useful as passenger vehicle engine oil (PVEO) products.Type: GrantFiled: June 30, 2016Date of Patent: November 6, 2018Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Jason Z. Gao, Eugine Choi, Matthew W. Boland, Luca Salvi
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Patent number: 10119091Abstract: A lubricant composition comprising an oil of lubricating viscosity and an N-hydrocarbyl-substituted aminoester, wherein the N-hydrocarbyl substituent comprises a hydrocarbyl group of at least 3 carbons atoms, with a branch at the 1 or 2 position of the hydrocarbyl chain, provides good iron and copper corrosion performance in driveline or gear applications.Type: GrantFiled: April 28, 2015Date of Patent: November 6, 2018Assignee: The Lubrizol CorporationInventors: Daniel J. Saccomando, Ewan E. Delbridge, William R. S. Barton
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Patent number: 10119092Abstract: The presently claimed invention is directed to the novel use of polyester obtainable by reacting a mixture comprising adipic acid and an alcohol mixture comprising 1-nonanol, monomethyloctanols, dimethylheptanols and monoethylheptanols as lubricants and a lubricant composition comprising these polyesters.Type: GrantFiled: November 8, 2013Date of Patent: November 6, 2018Assignee: BASF SEInventors: Markus Scherer, Boris Breitscheidel
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Patent number: 10119093Abstract: A lubricant composition for high compression spark ignition engines that contains at least one bismuth-containing compound (e.g., a bismuth salt of a carboxylic acid). A method for preventing or reducing engine knock and pre-ignition in an engine lubricated with a formulated oil. The formulated oil has a composition including at least one bismuth-containing compound (e.g., a bismuth salt of a carboxylic acid). A fuel composition for high compression spark ignition engines that contains at least one bismuth-containing compound (e.g., a bismuth salt of a carboxylic acid). A method for preventing or reducing engine knock and pre-ignition in an engine by using a fuel additive composition in a gasoline fuel composition. The fuel additive composition contains at least one bismuth-containing compound (e.g., a bismuth salt of a carboxylic acid). The lubricating oils of this disclosure are useful as passenger vehicle engine oil (PVEO) products.Type: GrantFiled: May 23, 2016Date of Patent: November 6, 2018Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANYInventors: Jason Z. Gao, Eugine Choi, Matthew W. Boland, Luca Salvi
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Patent number: 10119094Abstract: An antifriction coating composition which comprises: a resin binder, a polyamide thickener, solvent and a solid lubricant wherein the resin binder comprises a mixture of phenolic resin, epoxy resin and optionally a silicone resin.Type: GrantFiled: December 18, 2014Date of Patent: November 6, 2018Assignee: Dow Silicones CorporationInventors: Marita Barth, Vittorio Clerici
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Patent number: 10119095Abstract: A method for processing algae-based products using flue gas heat includes mixing flue gas with water, receiving a heated gas in a first enclosure of a heat exchanger, receiving an algal paste in a second enclosure of the heat exchanger, introducing an organic solvent to the algal paste, extracting an algal oil and a plurality of algal shells from the algal paste by dissipating heat from the first enclosure to the second enclosure; and extracting the algal oil from the organic solvent and the algal shells.Type: GrantFiled: January 31, 2017Date of Patent: November 6, 2018Assignee: T2 Energy, LLCInventors: Mark Randall, Mark Olson, Elmar Schmid
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Patent number: 10119096Abstract: Spearmint flavor enhancers and methods for the production thereof. The spearmint flavor enhancers may include l-carvone, l-carveol isomers, and d-dihydrocarveol isomers. The spearmint flavor enhancers may further include l-isocarveol isomers, l-carvyl acetate isomers, d-dihydrocarvyl acetate isomers, and l-isocarvyl acetate isomers.Type: GrantFiled: August 7, 2015Date of Patent: November 6, 2018Assignee: Symrise Inc.Inventors: Gennadiy G. Kolomeyer, Douglas Ferone
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Patent number: 10119097Abstract: A fragrance precursor represented by the formula 1 wherein X and Y together represent a double bond to a carbon atom bearing R1 and R2, with R1?H, methyl, acetyl or C1-C3 alkoxycarbonyl (e.g. ethoxycarbonyl); and R2=phenyl optionally substituted with up to 3 (i.e. 0, 1, 2 or 3) groups selected from C1-C4 alkyl (e.g. methyl, ethyl, iso-propyl, tert-butyl), vinyl, hydroxy, C1-C3 alkoxy (e.g. ethoxy), and —O—CH2—O—, e.g. R2 is benzo[d][1,3]dioxol-5-yl, 4-methylphenyl, 4-methoxyphenyl, 4-vinylphenyl or 3-ethoxy-4-hydroxyphenyl or R2=naphthyl, (naphthyl)methyl, 1,1,2,4,4,8-hexamethyl-1,2,3,4-tetrahydronaphthalen-7-yl, or 1,1,2,4,4,-pentamethyl-1,2,3,4-tetrahydronaphthalen-7-yl or R2=COR3, wherein R3 is H, C1-C10 alkoxy (e.g. ethoxy, 1-(3,3-dimethylcyclohexyl)ethoxy), C1-C4 alkyl (e.g. methyl, ethyl, propyl, iso-propyl, tert-butyl), e.g.Type: GrantFiled: November 10, 2014Date of Patent: November 6, 2018Assignee: GIVAUDAN S.A.Inventors: Corinne Baumgartner, Felix Flachsmann
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Patent number: 10119098Abstract: An enzymatic process for the kinetic separation of alkyl esters under organic solvent free conditions is disclosed. Alkyl esters obtained from e.g. fish oil are reacted with glycerol, in the presence of water, at different rates in an evacuated chamber. The reaction is terminated prior to reaching equilibrium and the enriched alkyl ester fraction is isolated from the reaction mixture by short path distillation.Type: GrantFiled: May 23, 2006Date of Patent: November 6, 2018Assignee: EPAX NORWAY ASInventors: Per Christian Saebo, Inge Bruheim, Daniele Mancinelli, Asgeir Saebo
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Patent number: 10119099Abstract: A cleaning solution including: a primary solvent; a secondary solvent; an oxidizing agent, wherein the oxidizing agent includes a peroxide; a surfactant system, wherein the surfactant system includes a nonionic surfactant, a first anionic surfactant, and a second anionic surfactant; and an antioxidant, wherein the antioxidant is characterized by the structure of formula I: wherein R1-R6, are each independently selected from the group including H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s); wherein at least three of R1-R6 include OH; and wherein at least one of R1-R6 includes an ester.Type: GrantFiled: January 10, 2017Date of Patent: November 6, 2018Assignee: Envirox, L.L.C.Inventors: Josh Clemence, Noah Durham
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Patent number: 10119100Abstract: A laundry detergent composition including an alkyl isethionate and a de-foaming agent.Type: GrantFiled: April 5, 2017Date of Patent: November 6, 2018Assignee: The Honest Company, Inc.Inventors: Kevin Ewell, Carolyn Shawn Murphy, Bradley J. Barron, Christopher Gavigan
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Patent number: 10119101Abstract: Disclosed herein are methods for improving safety and delivery of commercial application of cleaning compositions that include enzymes and other protein irritants. The methods reduce the mist and aerosolization of proteins so that inhalation and exposure to the same are reduced. According to the invention, when commercial pressurized sprayers are used to apply protein containing use cleaning compositions of up to 5 ppm protein, aerosolization is decreased to below 60 ng active protein per meter cubed. Applicants have also identified a specific metering tip/nozzle, dispense rate, and low pressure application of not more than 100 psi are critical to achieving the benefits of the invention.Type: GrantFiled: April 28, 2014Date of Patent: November 6, 2018Assignee: Ecolab USA Inc.Inventors: Nathan D. Peitersen, Charles Allen Hodge, Terrence Phillip Everson, Stephen James Engel
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Patent number: 10119102Abstract: The present application relates liquid hard surface cleaning compositions comprising from about 0.001 wt % to about 0.015 wt % of an ethoxylated alkoxylated nonionic surfactant or a copolymer, from about 0.01 wt % to about 0.08 wt % of a quaternary compound selected from the group consisting of a C6-C18 alkyltrimethylammonium chloride, a C6-C18dialkyldimethylammonium chloride, and mixtures thereof and at least about 90 wt % water. Methods of using such compositions and cleaning pads, wipes, and cleaning implements for use with such compositions are also disclosed.Type: GrantFiled: September 20, 2016Date of Patent: November 6, 2018Assignee: The Procter & Gamble CompanyInventors: Fernando Ray Tollens, Andrew James Fluxe
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Patent number: 10119103Abstract: A cleaning liquid including hydrofluoric acid, a tetrazole compound, and water. The tetrazole compound may be represented by the following Formula (B1) in which R1 is a hydrogen atom or an organic group and R2 is a hydrogen atom, a hydroxyl group, a mercapto group, an amino group, or an organic group.Type: GrantFiled: February 22, 2017Date of Patent: November 6, 2018Assignee: TOKYO OHKA KOGYO CO., LTD.Inventors: Tatsuo Goto, Kenji Seki
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Patent number: 10119104Abstract: A method of making a personal care article includes placing a converting frame on an anvil plate assembly with an anvil plate; placing at least one lower substrate on the anvil plate and the converting frame; securing the at least one lower substrate within the converting frame; placing a cleansing composition on the at least one lower substrate and within a perimeter of a centering guide on the anvil plate; laying at least one upper substrate over the cleansing composition and the at least one lower substrate; placing the converting frame and the anvil plate assembly on a target location of a heat press; and actuating the heat press to direct a heated seal plate onto the anvil plate, thereby contacting the at least one upper substrate and forming seal between the at least one upper substrate and the at least one lower substrate.Type: GrantFiled: March 10, 2017Date of Patent: November 6, 2018Assignee: The Procter & Gamble CompanyInventors: Eric Shane Henley, William Allen Watters, Darren Franklin King
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Patent number: 10119105Abstract: A hard surface cleaning composition and a method of cleaning a hard surface with a low drying time composition is provided. The hard surface cleaning composition comprises: 0.03 wt. % to 0.06 wt. % amine oxide; 0.15 wt. % to 1.50 wt. % of a glycol ether having an HLB between 6.5 and 7.0; and at least 97 wt. % water, by weight of the overall composition.Type: GrantFiled: November 3, 2016Date of Patent: November 6, 2018Assignee: The Procter & Gamble CompanyInventors: Nicole Jorja Parsons, Fernando Ray Tollens, Brian Christopher Groendyke
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Patent number: 10119107Abstract: The present invention are directed to a novel automated cell bioprinter and related methods for making three-dimensional tissue constructs with spatial organization of cells that provides: (i) organized cell placement and spatial assembly of multiple cell types in a reproducible manner (ii) direct and non-contact assembly of multiple cell types and/or cell layers without exerting damaging forces on the cells or tissues, (iii) retention of cell viability and functionality during assembly steps and long periods of culture, (iv) minimal use of harmful and toxic chemicals such as profuse amounts of mineral oil and buffer reagent, and (v) efficient layer-to-layer assembly of cell layers within the three-dimensional construct while (vi) avoiding the use of complicated surface treatments that prevents scale-up, and (vii) avoiding mutation-inducing radiations such as UV used to photocrosslink hydrogels.Type: GrantFiled: May 30, 2014Date of Patent: November 6, 2018Assignee: The University of AkronInventors: Hossein Tavana, David Petrak
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Patent number: 10119108Abstract: A manufacturing assembly has at least a sterilizable chamber containing at least one of a three-dimensional printing device (additive manufacturing), a Computer Numerical Controlled (CNC) finishing head (subtractive manufacturing), a vacuum-forming unit, an injection-molding unit, a laser-cutting unit, a ultrasonic-welding unit, a robotic arman analysis device, a sampling device or a combination thereof. A plurality of individual sterilizable chambers may be aseptically connected into a network of sterilizable chambers that provides additional functionality for the manufacturing assembly. A sterilizable printer assembly may include at least one printing head, a printing platform, and a driving mechanism adapted to perform a movement of the at least one printing head relative to the printing platform along three degrees of freedom; a printer housing enclosing the printer assembly in a sterile manner, at least one aseptic connector fluidly connected to a corresponding one of the at least one printing head.Type: GrantFiled: October 30, 2015Date of Patent: November 6, 2018Assignee: Sartorius Stedim Biotech GmbHInventor: Frank Maggiore
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Patent number: 10119109Abstract: An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.Type: GrantFiled: August 25, 2015Date of Patent: November 6, 2018Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAIInventors: Kevin D. Costa, Peter Backeris
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Patent number: 10119110Abstract: The present invention relates to devices and bioreactors capable of delivering oxygen to a cell culture using oxygen-carrying molecules. The bioreactor comprises at least two chambers separated by an oxygen-permeable membrane. The oxygen-carrying molecules are chosen from extracellular hemoglobin isolated from worm belonging to Arenicoliolae family or Nereidiolae family.Type: GrantFiled: April 21, 2010Date of Patent: November 6, 2018Assignee: HEMARINAInventor: Frank Zal
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Patent number: 10119111Abstract: By deleting a small area from an initial boundary image, a provisional boundary image is obtained (Step S211). A thinning processing is performed on the provisional boundary image to shape the image, and a thickening processing is performed on the thinned image to obtain a mask image (Steps S212 to S214). By masking the initial boundary image with the mask image, an updated provisional boundary image is obtained (Step S215). In the updated provisional boundary image, end points adjacent to each other are connected (Step S216). By repeating Steps S212 to S216, a broken boundary is repaired. As a result, even if a boundary of a cell colony is blurred, an area of the cell colony can be specified easily and efficiently.Type: GrantFiled: November 19, 2014Date of Patent: November 6, 2018Assignee: SCREEN HOLDINGS CO., LTD.Inventor: Akihiro Nomura
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Patent number: 10119112Abstract: The present invention relates to a unit (1) comprising a microsystem (150) and at least one set of interface connections (16) for the microsystem (150); the microsystem (150) comprising a bottom plate (152) bearing the impression of at least one microstructured dynamic cell culture chamber (15), and a top plate (151), characterized in that the at least one microstructured chamber (15) is fluidically connected at inlet and/or at outlet by a set of connections (16) inserted removably into a hole in the upper plate (151). The present invention also relates to a dynamic cell culture system to this effect.Type: GrantFiled: March 2, 2011Date of Patent: November 6, 2018Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)Inventors: Cécile Legallais, Régis Baudoin, Eric Leclerc, Jean-Matthieu Prot, Patrick Paullier
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Patent number: 10119113Abstract: Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.Type: GrantFiled: October 12, 2015Date of Patent: November 6, 2018Assignee: CYTORI THERAPEUTICS, INC.Inventors: Marc H. Hedrick, John K. Fraser, Michael J. Schulzki, Bobby Byrnes, Grace Carlson, Ronda Elizabeth Schreiber, Isabella Wulur
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Patent number: 10119114Abstract: A cartridge that can be positioned inside an air collection component and receive a component for recovering nucleic acids is described, the cartridge being substantially cylindrical and containing a microorganism retaining zone, the retaining zone containing a microorganism lysis mechanism. Also described is a device for collecting microorganisms contained in the air and a device for microorganism lysis.Type: GrantFiled: June 6, 2008Date of Patent: November 6, 2018Assignee: BIOMERIEUXInventors: Hermanus Johannes Maria Kreuwel, Emiel Gerebern Maria Verwimp
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Patent number: 10119115Abstract: Described herein are methods, compositions and synthetic biology approaches for solvent production, including but not limited to butanol production. Described herein are recombinant bacteria and yeast strains which may be used in production of a solvent, including but not limited to butanol, from lignocellulosic and other plant-based feedstocks. Described herein are methods of producing solvents, including but not limited to butanol, using bacteria and yeast strains. Described herein are methods of producing organisms that display highly efficient butanol production.Type: GrantFiled: July 10, 2015Date of Patent: November 6, 2018Assignees: The Board of Trustees of the University of Illinois, Eastman Renewable Materials, LLCInventors: Hans P. Blaschek, Steven F. Stoddard, Zhen Shi
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Patent number: 10119116Abstract: One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.Type: GrantFiled: March 27, 2017Date of Patent: November 6, 2018Inventor: Bobban Subhadra
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Patent number: 10119117Abstract: In one embodiment, the present application discloses a cell culture medium for culturing cell lines suitable for producing a therapeutic protein, comprising an amino acid selected from a group consisting of L-arginine, L-asparagine, L-proline, L leucine and L hydroxyproline and a mixture thereof; a vitamin selected from a group consisting of ascorbic acid Mg2+ salt, biotin, pyridoxine HCL, folic acid, riboflavin and D-calcium pantothenate, and a mixture thereof; an element selected from a group consisting of ammonium meta vanadate, sodium meta vanadate, germanium dioxide, barium acetate, aluminum chloride, rubidium chloride, cadmium chloride, ammonium molybedate, stannous chloride, cobalt chloride, chromium sulfate, silver nitrate, sodium metasilicate, zinc sulfate, manganese sulfate H2O, manganous chloride, ferric nitrate 9H2O, ferrous sulfate 7H2O, ferric ammonium citrate, magnesium chloride anhydrous, and magnesium sulfate anhydrous, and a mixture thereof; a nucleoside selected from a group consisting of uType: GrantFiled: January 11, 2017Date of Patent: November 6, 2018Assignee: NANOGEN PHARMACEUTICAL BIOTECHNOLOGY CO., LTDInventors: Nhan Ho, Praveen Gupta, Si Minh Do, Phuong Thi Bich Ho, Ngoc-Thuy Bui, Huy Quang Nguyen, Trang Thi Thuy Nguyen, Ha Thi Hong Truong, Tuan Anh Le
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Patent number: 10119118Abstract: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.Type: GrantFiled: June 20, 2016Date of Patent: November 6, 2018Assignee: AbbVie Inc.Inventors: Itzcoatl A. Pla, Joseph G. Matuck, John C. Fann, Christof Schulz, Nichole A. Roy, David F. Bruton, James McIntire, Yu-hsiang D. Chang, Thomas Seewoester
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Patent number: 10119119Abstract: A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for optimizing growth of a cell type, for example corneal endothelial cells.Type: GrantFiled: January 31, 2013Date of Patent: November 6, 2018Assignee: Carnegie Mellon University and University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Adam Walter Feinberg, James L. Funderburgh, Rachelle Simko
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Patent number: 10119120Abstract: The present invention provides a method for inducing differentiation of pluripotent stem cells into neural precursor cells, comprising culturing the pluripotent stem cells in the presence of a small molecule BMP inhibitor, and induced neural precursor cells prepared by this method.Type: GrantFiled: August 12, 2010Date of Patent: November 6, 2018Assignee: Kyoto UniversityInventors: Jun Takahashi, Asuka Morizane
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Patent number: 10119121Abstract: The technology relates in part to methods and compositions for ex vivo proliferation and expansion of epithelial cells.Type: GrantFiled: October 18, 2016Date of Patent: November 6, 2018Assignee: PROPAGENIX INC.Inventor: Chengkang Zhang
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Patent number: 10119122Abstract: The disclosure is concerned among others with means and methods for obtaining endothelial cells and to means and methods for in vitro cell culture comprising endothelial cells and pericytes and/or smooth muscle cells derived from the pericytes. The endothelial cells or the pericytes and/or smooth muscle cells, or both, are preferably derived from in vitro differentiated pluripotent stem cells.Type: GrantFiled: June 10, 2014Date of Patent: November 6, 2018Assignee: ACADEMISCH ZIEKENHUIS LEIDENInventors: Christine Lindsay Mummery, Valeriya Viktorovna Orlova
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Patent number: 10119123Abstract: The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced from this reprogramming are functionally equivalent to glial cells that arise from ectodermal origins.Type: GrantFiled: November 8, 2016Date of Patent: November 6, 2018Assignee: Case Western Reserve UniversityInventors: Paul J. Tesar, Robert H. Miller, Fadi J. Najm
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Patent number: 10119124Abstract: A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well the resulting virus and vaccines with the virus.Type: GrantFiled: October 13, 2016Date of Patent: November 6, 2018Assignee: Wisconsin Alumni Research Foundation (WARF)Inventors: Tokiko Watanabe, Yoshihiro Kawaoka
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Patent number: 10119125Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.Type: GrantFiled: June 26, 2017Date of Patent: November 6, 2018Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research InstituteInventors: Luk H. Vandenberghe, Eric Zinn
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Patent number: 10119126Abstract: The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing the nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.Type: GrantFiled: January 8, 2018Date of Patent: November 6, 2018Assignee: BASF PLANT SCIENCE COMPANY GMBHInventors: Laurent Marty, Toralf Senger
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Patent number: 10119127Abstract: Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various GPT proteins and GPT gene coding sequences isolated from a number of plant species. As disclosed herein, GPT proteins share remarkable structural similarity within plant species, and are active in catalyzing the synthesis of 2-hydroxy-5-oxoproline (2-oxoglutaramate), a powerful signal metabolite which regulates the function of a large number of genes involved in the photosynthesis apparatus, carbon fixation and nitrogen metabolism.Type: GrantFiled: March 8, 2016Date of Patent: November 6, 2018Assignees: Los Alamos National Security, LLC, University of Maine System Board of TrusteesInventors: Pat J Unkefer, Penelope S Anderson, Thomas J Knight
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Patent number: 10119128Abstract: The present invention relates to lipase variants and methods of obtaining them. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.Type: GrantFiled: June 9, 2016Date of Patent: November 6, 2018Assignee: Novozymes A/SInventors: Luise Erlandsen, Carsten Hoerslev Hansen, Jesper Vind, Allan Svendsen, Carsten Peter Sonksen
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Patent number: 10119129Abstract: The invention relates to an improved enzyme complex having a plurality of enzyme activities of an expression product obtained by fermentation of the genus Trichoderma in combination with one or more enzymes of a different fungus strain.Type: GrantFiled: May 7, 2010Date of Patent: November 6, 2018Assignee: DUPONT NUTRITION BIOSCIENCES APSInventors: Neville Marshall Fish, Lone Brønd Miller
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Patent number: 10119130Abstract: The present invention relates to isolated polypeptides having lysozyme activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: May 26, 2017Date of Patent: November 6, 2018Assignee: Novozymes A/SInventors: Kirk Matthew Schnorr, Jens Erik Nielsen, Mikkel Klausen
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Patent number: 10119131Abstract: The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.Type: GrantFiled: March 16, 2012Date of Patent: November 6, 2018Assignee: BIOSPECIFICS TECHNOLOGIES CORP.Inventors: Thomas L. Wegman, Bo Yu
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Patent number: 10119132Abstract: Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.Type: GrantFiled: November 23, 2015Date of Patent: November 6, 2018Assignee: OPKO Biologics Ltd.Inventors: Udi Eyal Fima, Gili Hart
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Patent number: 10119133Abstract: CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a Cas9 nuclease to a target DNA. Further disclosed are methods for increasing specificity of RNA-guided genome editing using CRISPR/Cas9 systems by using truncated guide RNAs (tru-gRNAs).Type: GrantFiled: March 14, 2014Date of Patent: November 6, 2018Assignee: The General Hospital CorporationInventors: J. Keith Joung, Jeffry D. Sander, Yan-fang Fu, Morgan Maeder
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Patent number: 10119134Abstract: Provided herein are methods and composition for immune repertoire sequencing and single cell barcoding. In some aspects, such methods may comprise steps of: (a) forming a plurality of vessels each comprising a first cell cDNA of a first cell polynucleotide from a single cell and a second cell cDNA of a second cell polynucleotide from the single cell; (b) extending the first cell cDNA that is hybridized to a barcoded polynucleotide comprising a primer binding site sequence and a barcode sequence and a cDNA annealing sequence, or an amplicon thereof; and extending the second cell cDNA that is hybridized to a barcoded polynucleotide comprising a primer binding site sequence and the barcode sequence and a cDNA annealing sequence, or an amplicon thereof; and (c) amplifying the extended first cell cDNA and the extended second cell cDNA with a primer set.Type: GrantFiled: March 14, 2014Date of Patent: November 6, 2018Assignee: AbVitro LLCInventors: Francois Vigneault, Adrian Wrangham Briggs
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Patent number: 10119135Abstract: The present invention relates to the identification of microRNAs of the miR-148 family that are involved in the pathogenesis of chronic pulmonary diseases. The present invention relates to micro RNA of the miR-148 family selected from miR-148a, miR-148b and miR-152 for use in the diagnosis, prognosis, prevention and/or therapy of a chronic pulmonary disease. The present invention further relates to miR-148 inhibitors, pharmaceutical compositions comprising such inhibitors, their use in preventing and/or treating chronic pulmonary diseases, and methods for preventing and/or treating chronic pulmonary diseases. The present invention further relates to transgenic, non-human mammals and methods for identifying modulators of miR-148 and methods for diagnosis and/or prognosis of chronic pulmonary diseases.Type: GrantFiled: May 15, 2013Date of Patent: November 6, 2018Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERGInventors: Marcus Mall, Raman Agrawal, Martina Muckenthaler
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Patent number: 10119136Abstract: One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene in vivo. The dsRNA duplex comprises one or more 4?-modifications in one or both strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for in vivo therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.Type: GrantFiled: January 9, 2015Date of Patent: November 6, 2018Assignee: ALNYLAM PHARMACEUTICALS, INC.Inventors: Muthiah Manoharan, Shigeo Matsuda, Kallanthottathil G. Rajeev, Ivan Zlatev
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Patent number: 10119137Abstract: The invention encompasses methods used in the sensitization and treatment of cancer based upon the expression of SGEF.Type: GrantFiled: July 7, 2016Date of Patent: November 6, 2018Assignee: The Translational Genomics Research InstituteInventor: Nhan Tran
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Patent number: 10119138Abstract: The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that further includes a tether having one or more linking groups, in which at least one of the linking groups is a cleavable linking group. The tether in turn can be connected to a selected moiety, e.g., a ligand, e.g., a targeting or delivery moiety, or a moiety which alters a physical property. The cleavable linking group is one which is sufficiently stable outside the cell such that it allows targeting of a therapeutically beneficial amount of an iRNA agent (e.g., a single stranded or double stranded iRNA agent), coupled by way of the cleavable linking group to a targeting agent—to targets cells, but which upon entry into a target cell is cleaved to release the iRNA agent from the targeting agent.Type: GrantFiled: September 9, 2016Date of Patent: November 6, 2018Assignee: Alnylam Pharmaceuticals, Inc.Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev
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Patent number: 10119139Abstract: Methods, compositions, devices, and kits for treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition are provided. The method of treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition in a subject includes administering an effective amount a miRNA-762 inhibitor to the subject, wherein the subject is identified as having a risk of developing and/or a need for treatment of the condition associated with fibrosis and/or collagen deposition. The kit includes a vial containing an miRNA-762 inhibitor and a device for use in a surgery creating a risk of fibrosis and/or collagen deposition. The composition includes a pharmaceutical composition comprising a miRNA-762 inhibitor and a second agent selected from the group consisting of: an angiotensin-converting enzyme (ACE) inhibitors, an angiotensin receptor blocker (ARB), another antihypertensive agent, a steroid, and combinations thereof.Type: GrantFiled: September 14, 2016Date of Patent: November 6, 2018Assignees: Vanderbilt University, Yale UniversityInventors: David G. Harrison, Kim Ramil Montaniel, Kasey C. Vickers, Jing Wu, Jay D. Humphrey, Matthew R. Bersi