Patents Issued in November 8, 2018
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Publication number: 20180318566Abstract: Implantable gas delivery device and methods, systems, and devices including same. According to one embodiment, the implantable gas delivery device includes a porous core that permits facile transport of gas throughout its open volume. The porous core has sufficiently high tensile strength to withstand pressurization without significant deformation. The porous core is generally planar and is shaped to include a pair of opposing surfaces and a periphery. Diffusion membranes are fixed to the two opposing surfaces of the porous core. A gas supply tube has one end inserted into the porous core and another end connectable to a gas source. The periphery of the porous core is sealed gas-tight, either with a gasket or by sealing the porous core and/or diffusion membranes. The device may be used to deliver a gas to an implanted cell capsule or to native cells or tissues or may be used to expel waste gas.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: Anthony A. Ferrante, Simon G. Stone
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Publication number: 20180318567Abstract: A percutaneous absorption agent delivery device with: a solvent-impermeable cover film that has a first layer and a second layer, which are integrally continuous via a first fold and are superimposed, a non-seal region and a seal region are formed between the first layer and the second layer, the non-seal region disposed along the first fold, the seal region to surround the outer peripheral section of the non-seal region except for the section along the first fold, and an endless cut portion forming the non-seal region formed in the cover film; a percutaneous absorption agent carrying member is disposed in the non-seal region between the first layer and the second layer, and fixed to the cover film on the inner side of the cut portion; and an adhesive sheet that is detachably affixed to the outer surface of the cover film.Type: ApplicationFiled: November 9, 2016Publication date: November 8, 2018Applicant: MEDRX CO., LTD.Inventor: Hidetoshi HAMAMOTO
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Publication number: 20180318568Abstract: According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface.Type: ApplicationFiled: July 19, 2018Publication date: November 8, 2018Inventors: Roger Ignon, Ed F. Nicolas
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Publication number: 20180318569Abstract: A system and method comprise positioning a medical device within a subject. The medical device includes a plurality of compartments and each of the plurality of compartments includes a ferrous material. Further, each of the plurality of compartments is configured to hold a substance. The system and method further include delivering electromagnetic radiation, by an electromagnetic radiation source, to the medical device and varying, by a controller, an amount of the electromagnetic radiation delivered by the electromagnetic radiation source for selectively heating the ferrous material of at least one of the plurality of compartments and selectively releasing the substance held in the at least one of the plurality of compartments for managing a condition.Type: ApplicationFiled: April 23, 2018Publication date: November 8, 2018Inventor: Bernard FRYSHMAN
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Publication number: 20180318570Abstract: An operation tool for a fluid injector includes a selective movement mechanism which moves the fluid injector between a first protruding position and a second protruding position in a housing of an outer cylinder. When the fluid injector is at the first protruding position, microneedles of a multi-microneedle device are protruded out to a first distance from the first open end. When the fluid injector is at the second protruding position to discharge a fluid via the microneedles, the microneedles are protruded out to a second distance from the first open end, which is shorter than the first distance. The selective movement mechanism includes a rotational-linear movement conversion mechanism which moves the fluid injector between the first and second protruding positions along a longitudinal center line of the outer cylinder based on a direction and an amount of rotation of the outer cylinder relative to the fluid injector.Type: ApplicationFiled: July 17, 2018Publication date: November 8, 2018Applicant: TOPPAN PRINTING CO., LTD.Inventors: Tomoya SUMIDA, Yumiko IKEDA, Masaki KONO, Yoshihiro KODAMA, Kazuhiko Shiomitsu
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Publication number: 20180318571Abstract: In various examples, a hub for a medical device includes a hub housing including a passage from a proximal end of the hub housing to a distal end of the hub housing. A valve is disposed within the hub. The valve is configured to allow passage of an insertable device through the valve while inhibiting leakage of fluid from the valve. A cap is engaged to the hub housing. The cap includes an opening therethrough sized and shaped to allow passage of the insertable device through the opening. The opening allows access to the passage of the hub housing. An angled sidewall is disposed within the hub. The angled sidewall is configured to retain and deform the valve into a curved shape.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: Hans P. Rieckmann, Hans Pflaumer, Grant A. Scheibe, Biswa P. Das, Joseph E. Lesser, Thomas E. Bailey
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Publication number: 20180318572Abstract: A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.Type: ApplicationFiled: November 8, 2017Publication date: November 8, 2018Applicant: TEVA MEDICAL LTD.Inventors: Menachem KRAUS, Eli SHEMESH
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Publication number: 20180318573Abstract: A rotatable connector for a breastmilk system. The connector can be customized to provide a range of rotatable motion based on a selected size, shape and material. The connector can be designed to allow a wide range of motion, as needed, during use. The connector can be located near or at least partially within a connecting component of the system, as desired. Some, or all, of the material of the connector can be designed to rotate in response to forces applied to the connector during use.Type: ApplicationFiled: April 30, 2018Publication date: November 8, 2018Inventor: Joseph Wach
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Publication number: 20180318574Abstract: A circuit for electrical stimulation of a brain is disclosed. The circuit may include a plurality of electrical stimulators, a plurality of electrodes, a crossbar switch, and a processing unit. Each of the plurality of electrical stimulators is configured to generate an electrical signal. The crossbar switch includes a plurality of individual switches. The processing unit is configured to provide a connection between at least one of the plurality of electrical stimulators and a first electrode of the plurality of electrodes through an individual switch of the plurality of individual switches by turning on the individual switch.Type: ApplicationFiled: July 18, 2018Publication date: November 8, 2018Inventors: Bahador Makkiabadi, Ahmadreza Mohammadzadeh Ghomian
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Publication number: 20180318575Abstract: Apparatus is provided that includes a parenchymal electrode, configured to be implanted in brain parenchyma of a subject identified as at risk of or suffering from a synucleinopathy; and a cerebrospinal fluid (CSF) electrode, configured to be implanted in a CSF-filled space of a brain of the subject, the CSF-filled space selected from the group consisting of: a ventricular system and a subarachnoid space. Control circuitry is configured to drive the parenchymal and the CSF electrodes to clear alpha-synuclein (aSyn) from the brain parenchyma into the CSF-filled space of the brain. Other embodiments are also described.Type: ApplicationFiled: May 2, 2018Publication date: November 8, 2018Applicant: RAINBOW MEDICAL LTD.Inventors: Yossi GROSS, Alex TENDLER, Gideon FOSTICK
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Publication number: 20180318576Abstract: An electrode array and a delivery assembly. The array is wrapped around a flexible core part of the delivery assembly. A sheath, also part of the delivery assembly, is disposed over the array and core. Steering cables extend through the core. Once the delivery assembly-encased array is inserted in the body, the combination is advanced to the tissue over which the array is to be deployed. By pulling on the steering cables the array and assembly are steered into position. Once the array is in position, the sheath is retracted, the array deploys over the target tissue.Type: ApplicationFiled: July 17, 2018Publication date: November 8, 2018Applicant: Stryker CorporationInventors: Timothy J. Bozung, Douglas A. Staunton
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Publication number: 20180318577Abstract: A lead comprising a lead body, a lead connector terminal affixed to a proximal end of the lead body, and a cuff body affixed to a distal end of the lead body, an electrode contact affixed to the cuff body, and an electrical conductor between the connector terminal and electrode contact. The lead further comprises a strap extending from a first region of the cuff body, a buckle disposed on a second region of the cuff body, and a locking feature, e.g., protuberance, ring, or wrinkle, associated with the strap. The locking feature is configured for being pulled through the buckle to dispose the cuff body around a nerve in response to a tensile force applied to the strap. The locking feature is configured for abutting an edge of the buckle in response to a release of the tensile force to secure the cuff body around the nerve.Type: ApplicationFiled: April 30, 2018Publication date: November 8, 2018Inventors: Boon Khai Ng, Siegmar Schmidt
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Publication number: 20180318578Abstract: An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.Type: ApplicationFiled: April 30, 2018Publication date: November 8, 2018Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCHInventors: Boon Khai Ng, William Dai
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Publication number: 20180318579Abstract: An active implantable medical device configured for chronic implant in a patient includes a housing. At least one of a radio frequency (RF) module configured to generate a therapeutic output signal in a form of a pulsed a RF signal, and deliver the signal to neural tissue of the patient, and a health information module configured to collect information directed to a mechanical integrity of an orthopedic implant device and an activity of the patient, is located within the housing. The housing is configured to be associated with an orthopedic implanted device through attachment to a piece of implant hardware, or engagement with a passageway through the orthopedic implanted device. Alternatively, an active implantable medical device is incorporated and integrated into a component of an orthopedic implanted device.Type: ApplicationFiled: October 6, 2017Publication date: November 8, 2018Inventors: Harry Puryear, Timothy J. Cox, Serafin Y. Samson, Nazmi Peyman, Omid Souresrafil, Gregory F. Molnar
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Publication number: 20180318580Abstract: A device for applying a product to be distributed on a skin of a user by iontophoresis, includes a body intended to receive the product to be distributed, including an electric current generator; and an applicator head mounted on the body, the applicator head including: at least one device for distributing the product to be distributed on the skin; and at least one first electrode) and one second electrode that are separated by an interelectrode zone, the first and second electrodes to receive an electric current from the generator.Type: ApplicationFiled: November 4, 2016Publication date: November 8, 2018Inventors: Franck MANDICA, Johan SABATTIER
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Publication number: 20180318581Abstract: A device for performing electrotherapeutic massage on the human head, neck, and shoulders includes an inner core structure, at least four protruding nodules, plural electrical wires, and an outer covering. The inner core structure has a central horizontal accommodating opening for accommodating the neck and plural horizontal cushion openings. The horizontal accommodating opening matches the curvature and alignment of the human cervical spine and the kyphotic curvature of the thoracic vertebrae. Each protruding nodule is made of an electrically conductive fabric and sewn to the wall of the corresponding horizontal cushion opening in order to deliver the electrical nerve stimulation pulses generated by an electrotherapeutic signal generator to the corresponding body portion, thereby relaxing the nerve and muscle groups therein. The electrical wires electrically connect the protruding nodules to the electrotherapeutic signal generator.Type: ApplicationFiled: May 25, 2017Publication date: November 8, 2018Inventor: Hoi Ming Michael HO
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Publication number: 20180318582Abstract: There is provided a system including a controller, a breathing sensor securable to a patient to determine breathing data of the patient, a pulse oximetry sensor securable to the patient to sense pulse oximetry data of the patient, and a stimulator securable to the patient to stimulate the patient. The controller configured to execute instructions to obtain the breathing data from the breathing sensor, obtain the pulse oximetry data from the pulse oximetry sensor, determine, based on the breathing data of the patient and the pulse oximetry data of the patient, whether the patient is to be stimulated, and deliver, using the stimulator, stimulations to the patient, in response to determining that the patient is to be stimulated.Type: ApplicationFiled: April 27, 2018Publication date: November 8, 2018Inventors: Steve Lee, Dipen Makadia, Amy Fisher, Youngjae Lee, Timothy Marcum
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Publication number: 20180318583Abstract: The embodiments and methods described herein relate to an improved functional electrical stimulation (FES) orthosis. An apparatus can include a frame assembly, an electrode assembly, and an electric stimulator. The frame assembly is removably coupleable to a portion of a limb. The electrode assembly is configured to be in electrical communication with a portion of a neuromuscular system of the limb, and includes first and second sets of electrodes. The electric stimulator is in electrical communication with the electrode assembly. The electric stimulator is configured to send a first signal substantially during a first time period and via a first channel to the first set of electrodes for stimulation of a neuromuscular system of the limb, and is configured to send a second signal, during at least one of the first time period or a subsequent second time period, via a second channel to the second set of electrodes for stimulation of the neuromuscular system of the limb.Type: ApplicationFiled: July 10, 2018Publication date: November 8, 2018Applicant: Bioness Inc.Inventor: Keith Sean MCBRIDE
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Publication number: 20180318584Abstract: A method and system for controlling neural activity in the brain, including performing a source localization procedure and a neurostimulation procedure, and using the former as a monitor to provide for feedback control of the latter.Type: ApplicationFiled: July 12, 2018Publication date: November 8, 2018Inventor: DON M. TUCKER
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Publication number: 20180318585Abstract: An electro-therapy device that generates a mixed electrical signal through electrodes, wherein the mixed electrical signal is a combination of at least two different frequencies, a first frequency having a first minimum and maximum microamp range and a second frequency having a different second minimum and maximum microamp range. The higher of the two frequencies is superimposed on the lower frequency, creating a current intensity window as an envelope along a profile of the lower frequency. The mixed electrical signal is automatically applied for a pre-determined period of time, and amplitude and/or duration and/or frequencies is varied according to a pre-set schedule.Type: ApplicationFiled: July 17, 2018Publication date: November 8, 2018Applicant: FAST TRACK TECHNOLOGIES, INC.Inventor: Geoffrey Pfeifer
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Publication number: 20180318586Abstract: An electrotherapeutic system for treating a visual disease is disclosed. The system includes a signal generator configured to generate a treatment waveform comprising a series of current pulses. Preferably, the current pulses have a peak current amplitude of 200 microamps or less. The system also includes a headset applicator comprising a headband and a headset. The headset has a magnetic slot configured to be mounted to a magnetic mount of the headband. The headset includes left and right eyecup electrodes each of which has a contact surface that is positioned for contact with a skin surface within left and right eye regions, respectively. Preferably, the contact surface of each of the left and right eyecup electrodes comprises an upper contact pad and a lower contact pad that have a total area in the range of about 1.10 cm2 to about 1.80 cm2. The headset is connectable to the signal generator and configured to deliver the treatment waveform to one or both of the left and right electrodes.Type: ApplicationFiled: May 2, 2018Publication date: November 8, 2018Inventor: Alfonso Salazar
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Publication number: 20180318587Abstract: A system and method are provided to deliver interleaved stimulation to nerve tissue of interest. The system and method comprises an array of stimulation electrodes. The array is configured to be implanted proximate to nerve tissue of interest. An implantable medical device (IMD) is coupled to the array. The IMD includes memory storing a composite resultant pulse (CRP) sequence comprising first and second component sequences of first and second resultant pulse trains, respectively. One or more pulses from at least one of the first or second component sequences are temporally shifted relative to a corresponding target component sequence. The IMD further comprises a pulse generating circuit and switching circuit coupled to an output of the pulse generating circuit and the array. The switching circuit is configured to connect the pulse generating circuit to different combinations of the electrodes.Type: ApplicationFiled: July 9, 2018Publication date: November 8, 2018Inventor: Banko I. Hadjiyski
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Publication number: 20180318588Abstract: Methods, devices and program products are provided. The method is under control of one or more processors within an implantable medical device (IMD), obtains cardiac signals that comprise candidate episodes over a period of time and updates an episode count and episode density clock based on the candidate episodes within the period of time. Further, the method determines whether the candidate episodes are indicative of a ventricular storm arrhythmia based on the episode count and episode density clock, identifies a storm origin characteristic of interest preceding onset of the candidate episodes and directs the IMD to perform a storm intervention based on the identifying operation.Type: ApplicationFiled: May 3, 2017Publication date: November 8, 2018Inventor: Malcolm Dennis
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Publication number: 20180318589Abstract: One aspect relates to a biocompatible composite system, an implantable medical device, and a manufacturing method for a biocompatible composite system. The biocompatible composite system includes a printed multi-layer circuit board and a feedthrough. The circuit board includes at least one electrically conductive via. The feedthrough includes an insulating ceramic base material and at least one electrically conductive cermet pathway. The pathway is embedded into the base material to form an electrically conductive and hermetically sealed connection to the via of the circuit board. The feedthrough and the circuit board are integrated into one composite part.Type: ApplicationFiled: May 1, 2018Publication date: November 8, 2018Applicants: Heraeus Deutschland GmbH & Co. KG, Heraeus Quartz America LLCInventors: Matthew Joseph DONELON, Robert DITTMER, Ulrich HAUSCH, Jens TROETZSCHEL
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Publication number: 20180318590Abstract: Implementations described and claimed herein provide systems and methods for delivering and retrieving a leadless pacemaker. In one implementation, a leadless pacemaker has a docking end, and the docking end having a docking projection extending from a surface. A docking cap has a body defining a chamber. The docking cap has a proximal opening into the chamber. The proximal opening is coaxial with a longitudinal axis of a lumen of a catheter. A retriever has a flexible grasper with a first arm disposed opposite a second arm. Each of the first arm and the second arm form a hinge biased radially outwards from the longitudinal axis. The docking cap locks the first arm and the second arm on the docking projection when the body is sheathed over the retriever until the flexible grasper is disposed within the chamber.Type: ApplicationFiled: May 5, 2017Publication date: November 8, 2018Inventors: Arundhati Kabe, Thomas B. Eby
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Publication number: 20180318591Abstract: Implementations described and claimed herein provide systems and methods for delivering and retrieving a leadless pacemaker. In one implementation, a leadless pacemaker has a docking end, and the docking end has a docking projection extending from a surface. A docking cap has a body defining a chamber. A retriever has sheaths extending with lumens distally from the chamber. A snare extends between the lumens forming a first snare loop pointing in a first direction and a second snare loop pointing in a second direction with a docking space formed therebetween. The snare is movable between an engaged position and a disengaged position by translating the first snare wire and the second snare wire within the first snare lumen and the second snare lumen. The engaged position includes the first snare wire and the second snare wire tightened around the docking projection within the docking space.Type: ApplicationFiled: May 5, 2017Publication date: November 8, 2018Inventors: Arundhati Kabe, Thomas B. Eby
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Publication number: 20180318592Abstract: An automated external defibrillator soft carrying case includes a first compartment and a second compartment. The first compartment is connected to the second compartment by a hinge mechanism. The first compartment is also detachably connected to the second compartment. A first compartment ceiling is connected to the first compartment by a second hinge mechanism. The first compartment ceiling includes a transparent window.Type: ApplicationFiled: April 30, 2018Publication date: November 8, 2018Inventor: Kevin Smith
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Publication number: 20180318593Abstract: In embodiments, a WCD system includes electrodes with which it senses an ECG signal of the patient. A processor may detect sequential peaks within the ECG signal, measure durations of time intervals between the peaks, including between non-sequential peaks, and identify a representative duration that best meets a plausibility criterion. The plausibility criterion may be that the representative duration is the one that occurs the most often, i.e. is the mode. Then a heart rate can be computed from a duration indicated by the representative duration and, if the heart rate meets a shock condition, the WCD system may deliver a shock to the patient. An advantage can be that the representative duration can be close to a good R-R interval measurement of a patient, notwithstanding noise in the ECG signal that is in the shape of peaks.Type: ApplicationFiled: April 9, 2018Publication date: November 8, 2018Inventor: Joseph L. Sullivan
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Publication number: 20180318594Abstract: An implantable cardioverter defibrillator (ICD) and methods of detection and treatment of dangerous and life-threatening heart rhythms by delivering real-time, customized low-energy pacing pulses to specific anatomy in the heart. The ICD includes a power source, a controller, powered by the power source, including an electronic processor, a memory, and a signal generator. The ICD also includes a lead coupled to the controller and an electrode that is in electrical communication with a His-bundle of a patient's heart. The ICD detects a ventricular arrhythmia of the patient's heart using the controller, and is configured to provide a pulsed defibrillation signal to the electrode to terminate the ventricular arrhythmia.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: Derek J. Dosdall, Ravi Ranjan
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Publication number: 20180318595Abstract: A device includes a therapeutic electromagnetic circuit configured to emit an electromagnetic field upon activation and a resilient shoe insole coating surrounding the therapeutic electromagnetic circuit, in which the therapeutic electromagnetic device has a circuit board, having an electromagnetic field generator thereon, an antenna, coupled to the circuit board and arranged to radiate the electromagnetic field generated by the electromagnetic field generator, a power source, coupled to the electromagnetic field generator via an activator, and the activator, in which the activator, when turned on, is configured to activate the electromagnetic field generator.Type: ApplicationFiled: February 20, 2018Publication date: November 8, 2018Inventor: John Robert Martinez
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Publication number: 20180318596Abstract: A skin microbiota modulation device that includes a cold plasma assembly configured to generate a cold plasma stimulus including a partially ionized gas mixture and to interrogate a biological surface with the cold plasma stimulus; and a microbiota seeding assembly including one or more target species of micobiota, the microbiota seeding assembly configured to deliver the one or more target species of micobiota to the biological surface.Type: ApplicationFiled: May 8, 2018Publication date: November 8, 2018Applicant: L'OREALInventors: Philippe BARBARAT, Richard MARTIN, Matthieu JACOB
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Publication number: 20180318597Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.Type: ApplicationFiled: July 9, 2018Publication date: November 8, 2018Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle, Steven Mendez
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Publication number: 20180318598Abstract: A pulsed electromagnetic field (PEMF) treatment apparatus having electrically-conductive loops arranged within an enclosure to form an array, each of the electrically-conductive loops having a generally circular circumference with one or more indentations aligned with a corresponding indentation of an adjacent electrically-conductive loop, where PEMF signals are generated through the array of electrically-conductive loops based on proximity detection conducted by a corresponding wireless device.Type: ApplicationFiled: May 7, 2018Publication date: November 8, 2018Inventors: Francis J. Russo, André DiMino
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Publication number: 20180318599Abstract: The invention provides a lighting system (10) comprising a first light source (100), a second light source (200) and a control system (20) configured to control the first light source (100) and the second light source (200), wherein: —the first light source (100) is configured to provide first light source light (101) comprising: (i) a UV component; and (ii) (iia) a blue component or (iib) a blue component and a yellow component; —the second light source (200) is configured to provide white second light source light (201) having a second light source light correlated color temperature (Tc2); —the lighting system (10) is configured to provide lighting system light (11) comprising one or more of said first light source light (101) and said second light source light (201), with the lighting system light (11) having a controllable correlated color temperature (Tc).Type: ApplicationFiled: October 25, 2016Publication date: November 8, 2018Inventors: Ties VAN BOMMEL, Rifat Ata Mustafa HIKMET
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Publication number: 20180318600Abstract: A radiant energy bandage system is disclosed including a plurality of therapeutic lamps and a controller for operating the lamps. Batteries power the lamps and are secured to a wearable fabric layer supporting the lamps and the controller. According to an exemplary embodiment, provided is a phototherapy device comprising a stretchable and/or flexible wearable therapeutic lamp platform including a plurality of radiant lamps configured to provide radiant energy to a user treatment area, a stretchable and/or flexible reflective wall including a plurality of radiant energy communication areas aligned with the radiant lamps and disposed to communicate the radiant energy to the user treatment area; and a stretchable and/or flexible adhesive layer including a first surface and a second surface, the first surface removably attached to the reflective layer and the second surface operatively associated with removably attaching the wearable therapeutic lamp platform to the user treatment area.Type: ApplicationFiled: July 16, 2018Publication date: November 8, 2018Inventors: Jay Tapper, David Shuter, Charles Peter Althoff, Jeff Michaelson, Bradley Feild Craddock, Lulin Ding, Marc-Aurélien Vivant
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Publication number: 20180318601Abstract: Certain examples involve a circadian effect light fixture. The circadian effect light fixture includes a controller to receive a modifying factor based on a circadian impact profile. The modifying factor includes an indication of an intensity value, a correlated color temperature value, and a color value over a range of time. The circadian effect light fixture also includes a first lighting element controlled by the controller to produce a first light output having a first intensity, a first correlated color temperature, and a first color value. Further, the circadian effect light fixture includes a second lighting element controlled by the controller to produce a second light output having a second intensity, a second correlated color temperature, and a second color value. A combined light output of the first lighting element and the second lighting element tracks the modifying factor over the range of time.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: David P. Ciccarelli, Daniel Aaron Weiss, Benjamin Marshall Suttles
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Publication number: 20180318602Abstract: Certain examples involve controlling a circadian impact of a lighting system. For instance, a lighting system includes a first lighting fixture. The first lighting fixture includes at least one lighting element to illuminate a first space and a first controller to control a first light output of the at least one lighting element. Additionally, the lighting system includes a first background circadian system that provides a first modifying factor to the first controller of the first lighting fixture. The first modifying factor is associated with a first circadian impact profile that specifies a first circadian impact level in the first space. Further, the first controller of the first lighting fixture controls the first light output based on the first modifying factor.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: David P. Ciccarelli, Daniel Aaron Weiss, Benjamin Marshall Suttles
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Publication number: 20180318603Abstract: The present disclosure is directed to a computer-implemented method for designing a patient-specific brachytherapy (BT) tandem applicator. The method is implemented using at least one processor in communication with at least one memory. The method includes receiving a radiation treatment plan for treating a region of interest. The radiation treatment plan includes a prescribed radiation dosage and patient anatomical data of the region of interested to be treated. The method also includes applying an inverse planning optimization model to determine an optimal thickness of an interior surface of the tandem applicator at a plurality of dwell positions within the region of interest. The method also includes generating a schedule of dwell times for the tandem applicator based on the generated position-dependent thickness profile. The method also includes transmitting design instructions to a 3D printer for fabrication of the tandem applicator.Type: ApplicationFiled: May 7, 2018Publication date: November 8, 2018Applicant: Washington UniversityInventors: Chunjoo Park, Sasa Mutic, Hao Zhang
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Publication number: 20180318604Abstract: It is an object of the invention to provide for an improved radiation treatment. According to a first aspect of the invention, this object is achieved by a method for determining a patient specific locally varying margin on a treatment target and/or an organ at risk in order to compensate for local intrafraction motion expected during a radiotherapy fraction to be delivered over a radiotherapy fraction time interval. The patient specific locally varying margin is determined based on a displacement and/or an estimate of the displacement of at least a first location and a second location on the treatment target and/or organ at risk.Type: ApplicationFiled: December 16, 2016Publication date: November 8, 2018Inventors: Nicole Schadewaldt, Jochen Peters
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Publication number: 20180318605Abstract: The invention relates to a system for generating a radiotherapy treatment plan (33; 34) for treating a target structure within a patient body. The system comprises (i) a modeling unit configured to determine a series of estimates (31a-d; 32a-d) of a delineation of the target structure for consecutive points of time during the radiation therapy treatment on the basis of a model quantifying changes of the delineation with time, and (ii) a planning unit configured to determine the treatment plan (33; 34) on the basis of the series of estimates (31a-d; 32a-d) of the delineation of the target structure. Further, the invention relates to method carried out in the system.Type: ApplicationFiled: November 7, 2016Publication date: November 8, 2018Inventors: Pedro Jorge Da Silva Rodrigues, Alfonso Agatino ISOLA, Andreia Maria Araujo TRINDADE RODRIGUES
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Publication number: 20180318606Abstract: Disclosed are systems and methods for the treatment of cardiac arrhythmias.Type: ApplicationFiled: November 7, 2016Publication date: November 8, 2018Inventors: Clifford G. Robinson, Phillip S. Cuculich
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Publication number: 20180318607Abstract: Devices, systems and method that allow for delivery of therapeutic radiation beams of differing sizes or shapes during a radiation treatment are provided herein. Such devices can include a rotatable collimator body having multiple collimator channels of differing size or shape defined therein, the channels extending through the collimator body substantially perpendicular to the axis of rotation. The collimator body can include markers thereon to facilitate detection of an alignment position by a sensor of a control system to allow the collimator body to be rapidly and accurately moved between alignment positions to facilitate delivery of differing therapy beams during a treatment.Type: ApplicationFiled: May 4, 2018Publication date: November 8, 2018Inventors: Raymond Wilbur, Younes Achkire, Manush Birang
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Publication number: 20180318608Abstract: The following relates generally to use of magnetic resonance (MR) imaging as guidance in radiation therapy, and more specifically to use of MR imaging as guidance in proton therapy. In some embodiments, a cryogenic dewar is provided with multiple channels allowing a proton beam from a proton beam source to pass through. The proton beam may first be aligned with a first channel, and the dewar may then be rotated along with the proton source. The dewar may then be rotated to align a second channel with the proton beam.Type: ApplicationFiled: December 1, 2016Publication date: November 8, 2018Inventors: PETER FORTHMANN, PHILIP ALEXANDER JONAS, JOHANNES ADRIANUS OVERWEG
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Publication number: 20180318609Abstract: This disclosure is related to an apparatus and method for commissioning or performing a quality assurance (QA) verification of a radiation therapy (RT) device. The device may comprise: (a) a motorised water phantom; (b) a RT controller configured for obtaining operation parameters of fields, and causing the RT device to emit a beam according to said operations parameters; (c) a QA controller having a memory for storing a measurements plan, the measurements plan including data defining a sequence of fields, and d) a reference radiation detector adapted and positioned for intercepting said radiation beam and for measuring the dose rate of said radiation beam. The reference radiation detector may be substantially transparent to the radiation beam. The QA controller may include an acquisition interface for acquiring and storing the dose rate from the reference radiation detector.Type: ApplicationFiled: May 1, 2018Publication date: November 8, 2018Applicant: Ion Beam Applications S.A.Inventors: Salih ARICAN, Christian VOGEL
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Publication number: 20180318610Abstract: A method is provided to disrupt tau entanglements and amyloid plaques in a person's brain. An ultrasound profile generated by an ultrasound device is applied to the person's brain. The generated ultrasound profile is characterized by a frequency between 20-100 kHz, a pulse power greater than 10 W/cm?2, a pulse length greater than 1 microsecond, and an interval between pulses greater than 1 millisecond. The method is performed without intravenous injection of microbubbles to the person or use of preformed microbubbles.Type: ApplicationFiled: April 28, 2018Publication date: November 8, 2018Inventor: Jaan Noolandi
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Publication number: 20180318611Abstract: A device to acoustically couple a patient to an MR-HIFU system includes a first membrane configured to acoustically couple to an ultrasound window of the MR-HIFU system, a second membrane configured to acoustically couple to the patient at an exposed region overlying an ultrasound focus of the MR-HIFU system, a continuous side wall that includes a first edge sealed to the first membrane and a second edge sealed to the second membrane, and an acoustic coupling fluid contained within a closed internal volume defined by the first membrane, the second membrane, and the continuous side wall. The device also includes a heat exchange device operatively coupled to the acoustic coupling fluid. The device is configured to form an impedance-matched ultrasound coupling between the ultrasound window and the exposed region of the patient and is further configured to regulate a temperature of the exposed region of the patient.Type: ApplicationFiled: May 8, 2018Publication date: November 8, 2018Applicant: Washington UniversityInventors: Hong Chen, Michael B. Altman, Satya V.V.N. Kothapalli
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Publication number: 20180318612Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.Type: ApplicationFiled: October 27, 2016Publication date: November 8, 2018Inventors: Eldad TZAHOR, Elad BASSAT
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Publication number: 20180318613Abstract: A respirator device and method for configuring the respirator device are provided. The respirator device includes at least one respirator element and a communications device. The commination device including a memory configured to store at least one setting of the communication device. The communication device including processing circuitry in communication with the memory and the communication device. The processing circuitry is configured to receive at least one audible tone and modify at least one setting of the communication device based on the received at least one audible tone. The communication device configured to operate according to the modified at least one setting.Type: ApplicationFiled: October 21, 2016Publication date: November 8, 2018Inventors: Darin Kyle Thompson, Todd Ronald Hunter, David Allen Amero, Jeremy Vance Barbee, Eric James Bassani, Paul Anthony Gale, Robert Heise
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Publication number: 20180318614Abstract: A portable chemical oxygen generator for delivering oxygen to a patient is described. The generator includes a housing containing a reaction chamber. Within the reaction chamber is a quantity of a peroxide adduct. A valve is provided with a lower portion of the valve in fluid communication with the reaction chamber. An upper portion of the valve is in fluid communication with a reservoir that holds a quantity of an aqueous solution. An internal chamber is formed within the valve by releasable seals that separate the internal chamber from the upper portion of the valve and a lower portion of the valve. The internal chamber holds a quantity of a peroxide-decomposing catalyst. The generator also includes a valve actuator. Operation of the valve actuator releases the seals in the valve and creates a fluid path from the reservoir through the internal chamber into the reaction chamber.Type: ApplicationFiled: July 2, 2018Publication date: November 8, 2018Applicant: Rapid Oxygen Company Inc.Inventors: Richard P. Imbruce, David Cowan
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Publication number: 20180318615Abstract: A rescue device for moving a subject comprising i) a brace member for securing the arms and the torso of the subject together, the brace member comprising i. a central section; ii. a first and second lateral section, and iii. fastening means; wherein the brace member is capable of forming a loop for securing the arms and the torso of the subject together by fastening the first lateral section to the second lateral section with the fastening means, and ii) a ribbon member pair for moving and/or stabilizing a subject wearing the brace member when said rescue device is in use, the ribbon member pair comprising i. a first ribbon member having a first portion connected to the brace member; and ii. a second ribbon member having a second portion connected to the brace member.Type: ApplicationFiled: January 21, 2016Publication date: November 8, 2018Applicant: MODITECH RESCUE SOLUTIONS B.V.Inventor: Paulus, Wilhelmus, Johannes, Maria VAN DER ZWAAN