Patents Issued in November 13, 2018
  • Patent number: 10124092
    Abstract: An air leak detection device is applied to a thoracic cavity drainage system which, by using negative pressure generated by a vacuum source, aspirates gas in the thoracic cavity of a patient via a water seal chamber in which liquid is received. The pressure between the vacuum source and the water seal chamber is measured by a pressure sensor, and the occurrence of air bubbles created in the water seal chamber is detected on the basis of fluctuations of this pressure.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: November 13, 2018
    Assignee: SENKO MEDICAL INSTRUMENT MFG. CO., LTD.
    Inventors: Hiroshi Yokoi, Norihisa Ichikawa, Souichi Katsuta, Masahiro Kihara
  • Patent number: 10124093
    Abstract: In one example embodiment, a system for stimulating healing of tissue at a wound site is disclosed. The system comprises a dressing including a porous pad and a drape covering the pad at a wound site for maintaining negative pressure at a wound site, a negative-pressure source including a pump and an electric motor to generate a pump pressure (PP) for applying to the wound site, and a first pressure sensor for sensing the pump pressure (PP). The system further comprises a controller coupled to the first pressure sensor and electric motor and including a PID controller that compares the pump pressure (PP) to a target pump pressure (TPP) and a bang-bang controller that controls wound pressure (WP) proximate the wound site, and wherein the controller is configured to alternatively select the bang-bang controller when the system is in a low-leakage condition or the PID controller when the system is in a high-leakage condition.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: November 13, 2018
    Assignee: KCI Licensing, Inc.
    Inventors: Loren Francis, Reuben Walter Edgar, Jr.
  • Patent number: 10124094
    Abstract: Devices and to methods for thoracic drainage for a patient having an air fistula. A vacuum is produced in the pleural cavity of the patient by means of a suction device. In order to adjust the vacuum on the basis of objective criteria, a suitable size measure for the air fistula is determined and the vacuum produced by the suction device is controlled according to said size measure. An adaptive algorithm includes: (a) determining a first value of a size measure for the air fistula; (b) changing the vacuum by a first difference value; (c) determining a second value of the size measure after a first waiting period; (d) changing the vacuum by a second difference value having the opposite sign if the second measure is greater than the first measure; (e) repeating steps (a) to (d) after a second waiting period.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: November 13, 2018
    Assignee: MEDELA HOLDING AG
    Inventors: Albert Linder, Hilmar Ehlert, Martin Walti
  • Patent number: 10124095
    Abstract: A fluid delivery system, method, and apparatus for providing instillation therapy with a negative-pressure source is described. The apparatus includes a housing having an ambient chamber and a negative-pressure chamber fluidly isolated from each other. The apparatus also includes a moveable barrier disposed in the housing between the ambient chamber and the negative-pressure chamber. The moveable barrier is operable to move between a charge position and a discharge position in response to negative pressure. A fluid source is disposed in the negative-pressure chamber and is collapsible in response to movement of the moveable barrier to the discharge position. The apparatus also includes a fluid outlet in fluid communication with the fluid source, a negative-pressure port in fluid communication with the negative-pressure chamber and configured to be coupled to a negative-pressure source, and a vent formed in the housing and fluidly coupled to the ambient chamber.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: November 13, 2018
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, James A. Luckemeyer, Timothy Mark Robinson
  • Patent number: 10124096
    Abstract: A suction device (10) includes: a suction portion (11) that sucks an external fluid; a piezoelectric pump (21) that includes a piezoelectric element (22) vibrating when a drive voltage is applied thereto and sucks the fluid via the suction portion (11) by vibration of the piezoelectric element (22); a detection circuit (32) that detects a phase difference between a current flowing through the piezoelectric element (22) and the drive voltage for the piezoelectric element; and a control unit (33) that performs a process on the basis of the phase difference detected by the detection circuit (32).
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: November 13, 2018
    Assignee: MURATA MANUFACTURING CO., LTD.
    Inventor: Kenjiro Okaguchi
  • Patent number: 10124097
    Abstract: A reduced-pressure system for delivering reduced pressure for medical purposes to a desired site and to receive fluids in one instance includes a reservoir having an interior space operable to contain the fluids. A reduced-pressure delivery conduit is placed in fluid communication with the interior space for delivering the reduced pressure to the desired site. A source conduit and a pressure sensor conduit are placed in fluid communication with the interior space. A pressure sensor is placed in fluid communication with the pressure sensor conduit. A reduced-pressure source is placed in fluid communication with the source conduit. A reduced-pressure control unit is associated with the pressure sensor and the reduced-pressure source and is operable to receive pressure data from the pressure sensor and supply data from the reduced-pressure source and to determine when a reservoir-full/blockage condition exists. Other systems and methods are presented.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: November 13, 2018
    Assignee: KCI Licensing, Inc.
    Inventors: Benjamin A. Pratt, Christopher Brian Locke, Aidan Marcus Tout
  • Patent number: 10124098
    Abstract: Certain embodiments described herein are directed to an elongated layer of material and a lip to be placed in contact with a wound and the elongated layer of material to be wrapped around a wound filler, their methods of use and systems incorporating the same, wherein the wound filler lip is configured to be positioned beneath the fascia. Additionally, some embodiments described herein are directed to the closure of the wound and the use of attachment mechanisms on the elongate layer and lip to attach to the wound surface.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 13, 2018
    Assignees: Smith & Nephew, Inc., University of Massachusetts
    Inventors: Raymond M. Dunn, Edward Yerbury Hartwell, John Kenneth Hicks, Elizabeth Mary Huddleston, Carl Saxby
  • Patent number: 10124099
    Abstract: A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle. When an arrhythmia is detected, the pump drive circuit may also run the pump in an atrial arrhythmia mode or a ventricular arrhythmia mode different from the normal pulsatile mode.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: November 13, 2018
    Assignee: HeartWare, Inc.
    Inventor: Barry M. Yomtov
  • Patent number: 10124100
    Abstract: A method and system are provided for percutaneously gaining access to oxygenated blood with one or more anastomosis devices and pumping such oxygenated blood directly to the aorta adjacent to the right atrium or left atrium via a VAD system. In one embodiment, a VAD system can be implanted with open surgery.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: November 13, 2018
    Assignee: Coherex Medical, Inc.
    Inventors: Brian K. Whisenant, Richard J. Linder, Scott D. Miles, David L. Stott, Randall K. Jones
  • Patent number: 10124101
    Abstract: A fluid resistant electrical connector for an implantable medical device includes a first connector assembly and a second connector assembly. The first connector assembly includes a first housing, an elongated coupling member, and first electrical contacts distributed around the coupling member. The second connector assembly includes a second housing, second electrical contacts, and a retention member. The second housing has a coupling member receptacle and a retention member receptacle. The coupling member receptacle is shaped to accommodate a distal portion of the coupling member. The retention member is partially accommodated by the retention member receptacle and movable between an insertion configuration accommodating coupling of the first and second connector assemblies and a retention configuration retaining the coupling member to prevent inadvertent uncoupling of the electrical connector.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: November 13, 2018
    Assignee: TC1 LLC
    Inventors: Kenneth Wong, George Chao-chih Hsu, Thomas Orduna, Shahn S. Sage
  • Patent number: 10124102
    Abstract: The invention is a heart assist device which has been developed in order to maintain the blood circulation in end-stage heart patients who do not respond to medical treatment, and it has been designed in size and shape so that it can be installed into the anatomically spacious root sections of the aorta and main pulmonary artery. With its small volume, and exceptional motor design without a shaft, the device, which contains a brushless, asynchronous and three-phase electric motor, will consume much less energy. The three-phase current required for the motor is provided from the power supply outside the body through the synchronous and wireless transmission of three phases. The invention is about a permanent endovascular cardiac support device which contains a three-phase, brushless, asynchronous electric motor, and the required energy is provided through the three-phase wireless power transmission from outside the body.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: November 13, 2018
    Inventors: Oran Bulent, Oran Omer Faruk, Avci Elif Oran
  • Patent number: 10124103
    Abstract: The present invention relates to a method for operating an extracorporeal blood treatment apparatus having an extracorporeal blood circuit for a hemodialysis and/or hemofiltration and/or hernodiafiltration by controlling an impeller pump. The invention furthermore comprises that the impeller blood pump is operated in a pulsating manner by adding a pulsating speed portion to a first constant speed.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: November 13, 2018
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Christoph Wiktor, Alexander Heide, Arne Peters
  • Patent number: 10124104
    Abstract: Provided is a temperature-based dialysate regeneration device for regulating a temperature of dialysate discharged from a hemodialyzer to remove uremic toxins and waste therefrom, the temperature-based dialysate regeneration device including: a Joule-Thomson refrigerator, including a compressor, condenser, expander and evaporator, an adsorbent column, and a dialysate heat exchanger in which heat transfer occurs between dialysates. The refrigerant used for the JT refrigerator may be a mixture of two or more refrigerants to enhance the heat transfer generated by the latent heat in the evaporator and the condenser.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: November 13, 2018
    Inventors: Taebeom Cho, Kyungsoo Lee
  • Patent number: 10124105
    Abstract: A device (1) for the extracorporeal oxygenation of the blood of a patient, comprising a containment casing (2) which has at least an inlet port (4) of the venous blood and at least an outlet port (5) of the arterial blood, at least an inlet channel (6) and at least an outlet channel (7) of a work gas intended to provide oxygen to blood and/or to remove CO2 from the same, at least a bundle of hollow fibers (8) arranged within the casing (2) and placed between the inlet channel (6) and the outlet channel (7), the hollow fibers being in communication with the inlet and outlet channels (6, 7) and being intended to be crossed by the relative work gas, at least a first and at least a second filtering elements (12, 13) arranged inside the bundle of hollow fibers (8) and spaced apart the one from the other, the filtering elements (12, 13) being able to trap any air bubbles present in the treated blood, where the first and second filtering elements (12, 13) define a relative open profile and where the hollow fibers (8
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: November 13, 2018
    Assignee: Eurosets S.r.l.
    Inventors: Antonio Petralia, Nicola Ghelli, Edgardo Costa, Roberto Balanzoni
  • Patent number: 10124106
    Abstract: The blood purification apparatus has a control device (19) that performs a venous returning blood process S1, an arterial returning blood process S4 and a negative pressure applying process S1a. The returning of the blood is performed by substituting a physiological saline solution for the blood in the blood circuit. The negative pressure applying process S1a releases a negative pressure after applying the negative pressure to a flow route on an upstream side from an arrangement position of a blood pump 4 in the arterial blood circuit (1). The blood pump (4) is in a normal rotation and an electromagnetic valve V3 switches over the physiological saline solution supplying line 8 from a closing state to a circulating state.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: November 13, 2018
    Assignee: Nikkiso Company Limited
    Inventors: Hiroshi Nimura, Kazumi Yokoyama, Tomohiro Furuhashi
  • Patent number: 10124107
    Abstract: The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: November 13, 2018
    Assignee: Gambro Lundia AB
    Inventors: Torbjorn Linden, Husam Mohammed
  • Patent number: 10124108
    Abstract: An apparatus for extracorporeal blood treatment (1) is described, comprising a treatment unit (3) having at least a first chamber (4) and at least a second chamber (5) separated from one another by a semi-permeable membrane (6); at least a blood removal line (7) connected to an inlet port (4a) of the first chamber (4) and predisposed to remove blood from a patient (P); at least a blood return line (8) connected to an outlet port (4b) from the first chamber (4) and predisposed to return treated blood to the patient (P), wherein the blood removal line (7), the blood return line (8) and the first chamber (4) are part of an extracorporeal blood circuit (2); at least a peristaltic pump (9) operating at the extracorporeal blood circuit (2) for moving the blood in the circuit; at least a pressure sensor (13, 14) associated to the extracorporeal blood circuit (2) and configured to enable determining pressure values in the extracorporeal blood circuit (2); at least a fluid drainage line (23) connected to an outlet por
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: November 13, 2018
    Assignee: GAMBRO LUNDIA AB
    Inventors: David Stefani, Mariano Ruffo
  • Patent number: 10124109
    Abstract: A medication treatment kit and method for treating difficult-to-manage disease that require medication be administered in a particular order for effective treatment where the treatment kit has a container, a first-line treatment medication within the container, and a second-line treatment medication within the container wherein the container is configured to ensure the first-line treatment medication and the second-line treatment medication are administered in proper order where there are no other medications located side-by-side relative to the first-line treatment medication and where only the first-line treatment medication is initially presented and where the first-line treatment medication and the second-line treatment medication are medications to treat a patient having a difficult-to-manage disease.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: November 13, 2018
    Assignee: Pharmaceutical Design, LLC
    Inventors: Allan M. Weinstein, Robert E. Weinstein
  • Patent number: 10124110
    Abstract: A fluid injector for use with at least one syringe has at least one injector head with a front end configured to releasably receive the at least one syringe. The fluid injector further includes at least one pressure jacket releasably associated with the front end of the at least one injector head for securing the at least one syringe during an injection procedure. A connection mechanism releasably connects the at least one pressure jacket to the front end of the at least one injector head. The connection mechanism includes at least one magnet. The at least one injector head has the at least one magnet while the at least one pressure jacket has a ferromagnetic material configured for magnetically interacting with the at least one magnet.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: November 13, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: James A. Dedig, Ralph H. Schriver, Patrick B. Campbell, Herbert M. Grubic
  • Patent number: 10124111
    Abstract: Disclosed is a small molecule dye for use in imaging in the near-infrared window, namely between 1000 nm-1700 nm wavelength. The present dyes are also useful for photoacoustic imaging and photothermal therapy. The dyes have a structure of a D-A-D (donor-acceptor-donor) fluorescent compound core and side chains rendering the compounds water soluble and easily conjugated to hydrophilic polymers and/or targeting ligands. Further disclosed is compound, CH1055 that can be PEGylated, conjugated to a targeting ligand, or conjugated to taurine. Key steps utilized to assemble the core structure of the target included a cross-Suzuki coupling reaction, iron reduction and N-thionylaniline induced ring closure. Four carboxylic acid groups were introduced into the donor-acceptor-donor (D-A-D) type fluorescent compound to impart a certain aqueous solubility and to allow facile conjugation to targeting ligands.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 13, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhen Cheng, Xuechuan Hong, Hongjie Dai, Hao Chen, Alexander Antaris, Kai Cheng
  • Patent number: 10124112
    Abstract: An infusion device comprising a fluid reservoir for containing a therapeutic fluid; and a transcutaneous access tool fluidly coupled to the fluid reservoir for delivering the therapeutic fluid subcutaneously and for introducing a monitoring test strip subcutaneously, and methods of use thereof.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: November 13, 2018
    Assignees: Insulet Corporation, Nova Biomedical Corporation
    Inventors: Steven DiIanni, Ian McLaughlin, Jason Brian O'Connor, Robert Campbell, Kevin Schmid, Thomas Peterson
  • Patent number: 10124113
    Abstract: Apparatus are provided for infusion devices and related operating methods. An exemplary device includes a sensing arrangement to provide an output indicative of a characteristic that is influenced by operation of the device, and a control module that is coupled to the sensing arrangement to apply a matched filter corresponding to a condition associated with the operation of the device to the output of the sensing arrangement and detect that condition based on the filtered output. In one example, the device includes a motor coupled to a plunger of a reservoir and operable to displace the plunger, wherein the characteristic is a force opposing displacement of the plunger and the control module detects an occlusion condition in a fluid path from the reservoir based on filtered force measurements.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: November 13, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: R. Marie Tieck, Juan M. Alderete, Jr., Matthew I. Haller
  • Patent number: 10124114
    Abstract: A method for identifying target regions in a tissue for local drug delivery, where functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and where the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: November 13, 2018
    Assignee: Brainlab AG
    Inventors: Raghu Raghavan, Martin Brady, Maria Inmaculada Rodriguez-Ponce
  • Patent number: 10124115
    Abstract: A push button safety injector includes a housing having a proximal end, a distal end spaced from the proximal end, and a longitudinal axis. An injection ram is positioned along the longitudinal axis and configured to actuate a fluid chamber. The injection ram is biased toward the distal end in an initial position. A sliding member is configured to retain the injection ram in the initial position. A safety member confines radial movement of the sliding member in the initial position and allows radial movement of the sliding member in an armed position. A button is moveable between an initial extended position and a depressed position. The button is engagable with the sliding member and configured to move the sliding member radially in the armed position. The sliding member releases the injection ram when the button is in the depressed position.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 13, 2018
    Assignee: ANTARES PHARMA, INC.
    Inventors: Kevin David Swanson, Julius Sund, Peter A. Hoeft, Patrick E. Madsen
  • Patent number: 10124116
    Abstract: An injection device with a feedback mechanism includes a housing for a medicament container having a stopper, a plunger rod for acting on the stopper, a button interactively connected to the plunger rod, an activation member having a flexible locking device releasably connected to the plunger rod, a drive force device, a locking member slidable between positions in which the locking member either completely or partially surrounds the flexible locking device, and a guide rod. Audible and tactile information that an injection has started is provided by the plunger rod's hitting the stopper.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: November 13, 2018
    Assignee: SHL GROUP AB
    Inventors: Sebastian Karlsson, Gunnar Elmen
  • Patent number: 10124117
    Abstract: A drug delivery device is provided herein which includes a tubular body defining an opening. A drug cartridge is also provided having a distal end larger in diameter than the opening. With the drug cartridge being inserted into the tubular body in a use position, the distal end of the drug cartridge is located at least partially externally of the tubular body. The medical pen injector of the subject invention further includes an adaptor engageable with the body. The adaptor encompasses the distal end of the drug cartridge with the drug cartridge being in the use position. The adaptor includes features for mounting a needle assembly thereto. Advantageously, with the subject invention, a drug cartridge having a large distal end may be accommodated with a drug delivery device, e.g., a pen injector type device.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: November 13, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Min Wei, Roger W. Groskopf, Ruane S. Jeter
  • Patent number: 10124118
    Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction, and a drive sleeve extending in the axial direction and being rotatable in a dose incrementing direction against the action of a spring enclosing at least an axial portion of the drive sleeve. The drive mechanism further includes a dose limiting member threadedly engaged with the drive sleeve, rotatably locked to the housing and at least partially extending radially between the drive sleeve and the spring, and at least one stop located on at least one of dose limiting member and drive sleeve for limiting an axial displacement of the dose limiting member relative to the drive sleeve.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 13, 2018
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
  • Patent number: 10124119
    Abstract: An injection device includes a housing having an aperture or window, and a dose indicator positioned within the housing. The dose indicator is rotatable with respect to the housing during dose setting and dose dispensing. The device includes a gauge element interposed between the housing and the dose indicator. The gauge element has a second aperture or window, which is positioned with respect to the first aperture or window such that at least a part of the dose indicator is visible through the first and second apertures or windows. The gauge element is axially guided within the housing and is in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element. A resilient member provides a force necessary for ejecting a dose from the injection device.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 13, 2018
    Assignee: Sanofi
    Inventors: Matthew Jones, Simon Lewis Bilton
  • Patent number: 10124120
    Abstract: A medical injector is provided herein having a body with a displaceable plunger. The plunger includes a plurality of spaced-apart ratchet teeth disposed along the length thereof. At least one indexer is provided formed to engage the plunger, wherein the indexer is configured to allow the plunger to displace distally towards a distal end of the body but not proximally towards a proximal end of the body. The medical injector also includes an actuator having an engagement portion formed to engage one or more of the ratchet teeth. The actuator is displaceable to a ready state, the engagement portion being displaced proximally relative to the plunger with the actuator being displaced to the ready state. The indexer prevents proximal movement of the plunger thereby allowing the engagement portion to by-pass one or more of the ratchet teeth with the actuator being displaced to the ready state. In addition, the actuator is displaceable from the ready state to cause actuation of the medical injector.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: November 13, 2018
    Assignee: Becton, Dickinson and Company
    Inventor: Richard A. Cronenberg
  • Patent number: 10124121
    Abstract: Described is a sheath removal mechanism (1) for removing a protective needle sheath (2) from an injection needle (3) of a syringe (4) in a drug delivery device (5). The sheath removal mechanism (1) comprises a cap (6) adapted to cover a distal end of a drug delivery device (5) and adapted to engage the protective needle sheath (2), and at least one rotatable cam (7) adapted to move the cap (6) in a distal direction (D) away from the syringe (4) when rotated from a first rotational position (P1) towards a second rotational position (P2).
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: November 13, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Andreas Bode
  • Patent number: 10124122
    Abstract: An attachment for a syringe or carpule includes a main body that encloses an interior space, into which a protrusion of the syringe or carpule can be inserted. The main body has a jacket surrounding the interior space, and includes an inner body connected to the jacket and arranged coaxially thereto. The inner body has an inner wall that, in the attached state of the attachment, contacts an outer surface of the protrusion or of the syringe or carpule by means of an interior surface facing the interior space. The inner wall of the inner body is connected to the jacket of the attachment by a number of webs. At least one web encloses an angle together with an imaginary radially extending line, the angle being greater than 0° and acute.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: November 13, 2018
    Assignee: VETTER PHARMA-FERTIGUNG GMBH & CO. KG
    Inventor: Jochen Zenker
  • Patent number: 10124123
    Abstract: The invention relates to a reusable syringe with a syringe body for receiving an ampoule. At the front end of the syringe body there is an opening which defines an axis along which a needle can be inserted. A plurality of holding segments are arranged around this axis and engage behind a needle carrier in the longitudinal direction. According to the invention, a holding segment designed as a thread part is movable in the radial direction. The invention further relates to a system composed of a reusable syringe, a needle carrier, and a container for used needles. Moreover, the invention includes an associated method for connecting and releasing a needle of a reusable syringe. The movable holding segment facilitates the release of the threaded connection of the needle carrier from the syringe body and makes the reusable syringe safer to use.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: November 13, 2018
    Assignee: TRANSCODENT GMBH & CO. KG
    Inventor: Philipp Rolle
  • Patent number: 10124124
    Abstract: A method for assisting subchondral injection comprising creating a model of bone and soft tissue of a patient. At least one void is modeled in the bone from the model of bone and soft tissue. An injection site is identified from the model of bone and soft tissue and modeling of the at least one void. Data is output for guiding at least in the locating of the injection site and drilling of the bone to reach the void. A patient-specific jig for subchondral injection may be created based on the injection site location.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: November 13, 2018
    Assignee: ZIMMER, INC.
    Inventors: Pierre Couture, Louis-Philippe Amiot, Laurence Mercier
  • Patent number: 10124125
    Abstract: A nebulizer includes an insertable container and a securing mechanism for holding the container in the nebulizer such that the container can move back and forth but cannot be separated. The securing mechanism is formed by a metal unitary part. The securing mechanism forms a transportation lock for holding the container unmovable in the housing in a delivery state of the nebulizer. The securing mechanism forms a cage which encompasses the container.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: November 13, 2018
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Alexander Bach, Jens Besseler, Holger Holakovsky, Manuel Daelman, Gilbert Wuttke
  • Patent number: 10124126
    Abstract: A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles. Through circulation of oxygen microbubbles through the body cavity, oxygen and carbon dioxide exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen-intake restricting injury and/or failure may be achieved through use of the invented system and methods.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: November 13, 2018
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Mark A. Borden, Benjamin S. Terry
  • Patent number: 10124127
    Abstract: A wearable wrist inhaler includes a wristband having a first end and a second end configured for wear about a user's wrist. An inhaler unit is removably coupled to the wristband displaced from the first end and the second end, the inhaler unit including a housing having a plurality of walls defining an interior area and an outlet port in communication with the interior area. A watch assembly is positioned atop the housing of the inhaler unit, the watch assembly energized by a battery and includes a display configured to indicate a time of day. A dosage chamber including a medicament is positioned in the interior area of the housing. A dispensing assembly is communication with the inhaler medicament that is configured to dispense an individual portion of the medicament via the outlet port upon demand by a user.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: November 13, 2018
    Inventor: Kendra Baldwin
  • Patent number: 10124128
    Abstract: An aerosolization apparatus comprises a body having an inlet, an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber. The apparatus further includes a connection mechanism to provide selective connection of the endpiece to the body, wherein a rotational force between the endpiece and the body is needed to connect or disconnect the endpiece from the body, the rotational force being applied about an axis passing through the chamber. When a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet. The connection mechanism prevents inadvertent disconnection of the endpiece from the body.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: November 13, 2018
    Assignee: BGP Products Operations GmbH
    Inventors: John D. Burr, Jeff R. Wood, Adrian E. Smith, John A. Howard, Fabrizio Niccolai
  • Patent number: 10124129
    Abstract: The invention relates to a dispensing device, a storage device and a method for dispensing a medical formulation. Multiple doses of the formulation are stored in a carrier having multiple storage members, each storage member containing a single dose. Each storage member comprises one duct or nozzle for dispensing the respective dose. The dispensing direction of the ducts or nozzles is directed in a lengthwise or indexing direction of the carrier. The storage device of the carrier is a peelable blister strip, wherein the ducts or nozzles can be opened one after the other by peeling the blister strip.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: November 13, 2018
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Stephen T. Dunne, Achim Moser
  • Patent number: 10124130
    Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: November 13, 2018
    Assignee: Pfizer Limited
    Inventors: Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
  • Patent number: 10124131
    Abstract: An incremental dose counter for a metered dose inhaler having a body arranged to retain a canister for movement of the canister relative thereto, the incremental dose counter having a main body, an actuator arranged to be driven and to drive an incremental output member in a count direction in response to canister motion, the actuator being configured to restrict motion of the output member in a direction opposite to the count direction.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 13, 2018
    Assignees: Ivax Pharmaceuticals Ireland, Norton (Waterford) Limited, Teva Pharmaceuticals Ireland
    Inventors: Declan Walsh, Derek Fenlon, Simon Kaar, Jan Geert Hazenberg, Dan Buck, Paul Clancy, Robert Charles Uschold, Jeffrey A. Karg
  • Patent number: 10124132
    Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 13, 2018
    Assignee: OptiNose AS
    Inventor: Per Gisle Djupesland
  • Patent number: 10124133
    Abstract: An electronic flow monitor, a control method and an anesthesia machine. The electronic flow controller can comprise a control module, an oxygen gas branch for delivering oxygen gas, an equilibrium gas branch for delivering equilibrium gas, and a gas mixing branch for mixing the oxygen gas and the equilibrium gas. The control module can meter an oxygen gas flow and an equilibrium gas flow through flow sensors. A first flow controller can be disposed in the oxygen gas branch, and a second flow controller can be disposed in the equilibrium gas branch. The first flow controller may be used to regulate the gas flow in the oxygen gas branch between zero and a maximum value and the second flow controller may be used to regulate the gas flow in the equilibrium gas branch between zero and a maximum value.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: November 13, 2018
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Honglei Li, Sheng Wang, Li Han
  • Patent number: 10124134
    Abstract: A patient interface mask for use with a breathing assistance apparatus includes a seal that, in use, circumscribes a nose, mouth, or nose and mouth of a patient and defines an interior space of the mask. The mask includes an inlet into the interior space and an outlet from the interior space. A sensor is positioned outside of the interior space and in the path of exit gases exiting the interior space through the outlet. The sensor detects a parameter of the exit gases, such as temperature, humidity or both.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: November 13, 2018
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Nimansha Budhiraja, Nordyn Alami
  • Patent number: 10124135
    Abstract: A blower includes a housing including an inlet and an outlet, a motor to drive a rotatable shaft, first and second impellers provided to the shaft, the first and second impellers each including a plurality of impeller blades, a first stationary component provided to the housing and including stator vanes downstream of the first impeller, and a second stationary component provided to the housing and including stator vanes downstream of the second impeller. A first set of stator vanes of the first stationary component is provided around the motor and are configured and arranged to direct airflow along the motor, to de-swirl the airflow and to decelerate air to increase pressure. A blower including a third impeller and third stationary component positioned above the first impeller is also described.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: November 13, 2018
    Assignee: ResMed Motor Technologies Inc.
    Inventors: Barton John Kenyon, Jeegarkumar Kapadia, Melanie Lucia Cariola, Michael Bruce Moir, Aleksandr S. Nagorny, Christopher Scott Edwards, James McKensey Bencke, Paul Andrews Dickens
  • Patent number: 10124136
    Abstract: Devices and methods for delivering air to a patient are provided. A device includes a first portion having a first airflow inlet and a first impeller configured to move in response to airflow from the first airflow inlet contacting the first impeller, the first portion defining a first airflow path; a second portion having a second airflow inlet, a second impeller, and an outlet for communicating airflow to a patient, the second portion defining a second airflow path; and means for coupling the first portion and the second portion, such that movement of the first impeller causes corresponding movement of the second impeller, wherein the second impeller is configured to impel air through the second airflow inlet and out of the outlet to the patient, upon movement of the second impeller and wherein the first and second airflow paths are not in fluid communication.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: November 13, 2018
    Assignee: Garland Hill
    Inventor: Garland Hill
  • Patent number: 10124137
    Abstract: A sealing device (20) includes a base (22) adapted to attach at any of a plurality of positions on a patient interface device (8), an arm (26) having a first end coupled to the base (22), and an end portion (24) connected to a second end of the base and adapted to apply pressure to an area of a cushion member (12) of the patient interface (8) device when the base is attached at any of the plurality of positions on the patient interface device.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: November 13, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Lauren Patricia Chodkowski
  • Patent number: 10124138
    Abstract: A sealing interface forms part of an apparatus for supplying a flow of respiratory gases to a user. The sealing interface comprises a foam or gel inner cushion and a thin resilient rubber outer sheath. A face side of the inner cushion resiliently supports the outer sheath. The inner cushion has a toothed profile formed on the face side of the inner cushion. The toothed profile consists of at least one tooth having an apex on the perimeter of the inner cushion. The apex is positioned between two valleys in the perimeter of the inner cushion. In use the apex of each tooth of the toothed profile is in supporting contact with the outer sheath.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: November 13, 2018
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Alastair Edwin McAuley, Mark McLaren, Wen Dong Huang
  • Patent number: 10124139
    Abstract: A patient interface device (30, 230, 330, 430, 530, 630, 730) that includes a support member (34, 234, 334, 434, 534, 634) comprising a central support portion and of cheek mount supports (70) coupled to the central portion. Each cheek mount support is configured to apply a force a side a user's cheekbone while applying substantially no force over an apex of such a user's cheekbone responsive to the patient interface being worn by a user. A seal member (36, 236, 336, 436, 536, 636, 736) is coupled to the support portion. The seal member is adapted to seal against a surface of a user to communicate a flow of gas with an airway of such a user. A conduit coupling member (38, 355, 438a, 438b, 538) is coupled to the seal member.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: November 13, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Jerome Matula, Jr.
  • Patent number: 10124140
    Abstract: In some embodiments, an atmosphere conditioning device may include a housing which may form a cavity. An air inlet may be formed into the housing, and the air inlet may be in fluid communication with the cavity. A filter medium which may govern the entrance of atmosphere into the cavity may be coupled with the housing so that the filter medium may be in fluid communication with the cavity and the first air inlet. A first air outlet may be disposed on the first side of the housing, and the first air outlet may be in fluid communication with a first air motivator. The first air motivator may also be in fluid communication with the cavity and may motivate conditioned air, which has passed through the filter medium, from the cavity and out of the device through the first air outlet.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: November 13, 2018
    Inventors: Ashoke Seth, Rashmi Seth
  • Patent number: 10124141
    Abstract: A breathing circuit for delivering heated, humidified gases to a patient for medical purposes is described, comprising a humidifier chamber holding a quantity of water, a blower unit that delivers a pressurized gases stream to the chamber inlet, and a control system that adjusts output parameters of the breathing circuit, the circuit including a heater plate which heats the water in the chamber so that gases flowing through the chamber become heated and humidified, the circuit also including a gases transportation pathway and patient interface to convey heated humidified gases to a patient, the gases transportation pathway including an RFID tag located at the patient end which senses a parameter of the gases passing through the pathway, the control system including an RFID interrogator interrogating and receiving data relating to the sensed parameter from the RFID tag in real time, and adjusting the output parameters of the breathing circuit accordingly.
    Type: Grant
    Filed: January 23, 2008
    Date of Patent: November 13, 2018
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Andrew Robert Donald Somervell, Nordyn Alami, Dexter Chi Lun Cheung, Christopher Simon James Quill, Matthew Jon Payton