Patents Issued in November 27, 2018
  • Dental fillers and compositions including phosphate salts
    Patent number: 10137061
    Abstract: The present application provides dental fillers, and methods of making and using dental fillers that include a treated surface that includes a phosphate salt. Dental compositions including such dental fillers can be useful for delivering ions to the oral environment. Dental compositions, and methods of using dental compositions that include a phosphate salt and a hardenable resin or a water-dispersible, polymeric film former are also provided.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: November 27, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Richard P. Rusin, Sumita B. Mitra, Kevin M. Cummings
  • Dry wipe to decrease frizz, static and increase shine on hair and aid in prevention of reoccurance of static and frizz
    Patent number: 10137062
    Abstract: The disclosure relates to methods of reducing static on hair or a cloth material, reducing hair frizz and/or increasing shine on hair by wiping the hair or cloth material with a dry wipe product. The dry wipe product comprises a flexible substrate having a first side and a second side; and either an anhydrous composition, or an aqueous composition, disposed over the first and/or second side(s) of the flexible substrate. When hair or cloth material is wiped with a side of the dry wipe product having the anhydrous composition or the aqueous composition disposed thereon, the anhydrous composition or aqueous composition is transferred from the flexible substrate of the dry wipe product to the hair or cloth material. The anhydrous compositions and aqueous compositions of the instant disclosure reduce static on hair and/or cloth, reduce hair frizz and/or increase shine on hair.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 27, 2018
    Assignee: L'OREAL
    Inventors: Michelle Salese, Jolene Morris, Chelsea Ali
  • Dye composition comprising nonionic guar gum or a nonionic derivative thereof, process and device for the same
    Patent number: 10137063
    Abstract: The present invention relates to a composition for dyeing human keratin fibers such as the hair, in mousse form, comprising: (a) at least one oxidation dye precursor; (b) at least one amphoteric or zwitterionic surfactant; (c) at least a second surfactant chosen from nonionic and anionic surfactants, or mixtures thereof; (d) at least one fatty substance; (e) at least one nonionic guar gum. The invention also relates to a process for dyeing human keratin fibers, in which is applied a composition preferably in foam form, obtained by mixing the above mentioned composition, free of oxidizing agent other than atmospheric oxygen, with a composition comprising at least one oxidizing agent other than atmospheric oxygen, and also to a suitable multi-compartment device.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: November 27, 2018
    Assignee: L'OREAL
    Inventors: Delphine Charrier, Geraldine Fack
  • Foaming cleanser
    Patent number: 10137064
    Abstract: The invention relates to a foaming cleanser cosmetic composition containing, in a physiologically acceptable medium: —a surfactant system comprising (i) at least one N—(C6-C30)acyl-amino based surfactant and (ii) at least one amphoteric surfactant chosen from betaines or (C8-C20)alkyl betaines, (C8-C20)alkylamido(C1-C6)alkylbetaines and mixtures thereof; and—at least one non associative crosslinked copolymer or acrylic acid and/or methacrylic acid, and optionally of (C1-C4)alkyl esters thereof, wherein said N—(C6-C30)acyl-amino based surfactant being present in the surfactant system in a major weight amount, and the surfactant system being present in the composition in an amount of less than 15% by weight relative to the total weight of the composition.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: November 27, 2018
    Assignee: L'OREAL
    Inventors: Hiroyasu Mizuno, Anne-Laure Bernard
  • Deodorant composition and deodorant product comprising a deodorant composition
    Patent number: 10137065
    Abstract: The present invention relates to a cosmetic composition which is an antiperspirant and/or deodorant fluid composition to be applied to the human skin, the composition being a non-aluminum based fluid composition free from alcohols and oils, comprising sodium or potassium bicarbonate as the essential deodorizing agent.
    Type: Grant
    Filed: March 20, 2016
    Date of Patent: November 27, 2018
    Assignee: ODOURLESS SWEDEN AB
    Inventor: Thomas Odén
  • Controlled release active agent carrier
    Patent number: 10137066
    Abstract: The present invention relates to carriers for the controlled release of active agents, comprising surface reacted natural or synthetic calcium carbonate, one or more active agents, wherein said one or more active agent is associated with said surface-reacted calcium carbonate, and wherein said surface-reacted natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source. It further relates to the preparation of loaded carriers, as well as their use in different applications.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: November 27, 2018
    Assignee: Omya International AG
    Inventors: Patrick A. C. Gane, Joachim Schoelkopf
  • Two-component products in bags for the oxidative dyeing of keratin fibres
    Patent number: 10137067
    Abstract: Products for oxidatively changing the color of keratinic fibers include at least two preparations (A) and (B), which are produced separately from one another. The first preparation (A) includes, in a cosmetic carrier, (A1) hydrogen peroxide and (A2) at least one chelating agent chosen from a group of specific chelating agents. The second preparation (B) includes, in a cosmetic carrier, (B1) at least one alkalizing agent. The preparation (A) is produced in a first container (container A). The first container includes at least two layers: an inner layer that includes a layer of a synthetic polymer (I) and an outer layer that includes a metal layer. Preparation (B) is produced in a second container (container B), which includes at least two layers: an inner layer that includes a layer of a synthetic polymer (I) and an outer layer that includes a metal layer.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: November 27, 2018
    Assignee: Henkel AG & Co. KGaA
    Inventor: Burkhard Mueller
  • Method for maintaining the color of dyed and/or highlighted keratin fibres
    Patent number: 10137068
    Abstract: A method for the color retention of dyed keratin fibers is provided herein. The method includes i. applying a cosmetic composition to dyed keratin fibers as a pretreatment agent for keratin. The method further includes ii. subjecting the keratin fibers to a dyeing and/or brightening within a period of about 5 seconds to about 24 hours after to step i. The cosmetic composition has, based on its own weight, from about 0.01 to about 4.00% by weight of at least one alum and a pH value in the range of about 2.5 to about 5.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: November 27, 2018
    Assignee: Henkel AG & Co. KGaA
    Inventors: Erik Schulze zur Wiesche, René Krohn
  • Skin cosmetic composition, antibacterial agent for skin cosmetic, and method for enhancing antibacterial effect of diol compound
    Patent number: 10137069
    Abstract: The present invention provides a skin cosmetic composition including a component (A) which is either one or both of hexyl glyceryl ether and cyclohexyl glyceryl ether, a component (B) which is either one or both of 1,2-propanediol and 1,3-propanediol, and a component (C) such as citric acid, an antibacterial agent including components (A), (B) and (C) and a method for enhancing an antibacterial effect of the component (A).
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: November 27, 2018
    Assignee: ADEKA CORPORATION
    Inventors: Yasuhiro Tsushima, Hiroshi Suzuki
  • Composition including ionone or salt thereof as active ingredient and having effect of enhancing skin moisturizing, exfoliating skin, improving skin elasticity, inhibiting erythema, improving skin wrinkles, or alleviating skin photoaging
    Patent number: 10137070
    Abstract: Provided herein are a cosmetic composition, a health functional food composition, a pharmaceutical composition, and a quasi-drug composition that include ionone or a salt thereof as an active ingredient and have an effect of enhancing skin moisturizing, exfoliating skin, improving skin elasticity, inhibiting erythema, improving skin wrinkles, or alleviating skin photoaging.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: November 27, 2018
    Assignee: YONSEI UNIVERSITY TECHNOLOGY HOLDINGS, INC.
    Inventor: Tae Sun Park
  • Nitrone inhibition of oxidation of unsaturated fats
    Patent number: 10137071
    Abstract: Provided are methods for inhibiting oxidation of unsaturated fats comprising blending the unsaturated fats with an effective amount of an antioxidant compound of Formula I: wherein R, R1, R2, R3, R4, R5 and R6 are as defined herein.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: November 27, 2018
    Assignees: Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Cassie Fhaner, Kinjalbahen Joshi, Yujing Tan
  • Methods and compositions for providing broad spectrum photo protection using antioxidants
    Patent number: 10137072
    Abstract: The present disclosure relates to methods and compositions for providing at least broad spectrum photo protection to skin, which includes protection from at least infrared (IR) radiation and/or visible light. The methods typically entail applying to skin a cosmetic composition comprising: (a) one or more antioxidants selected from the group consisting of baicalin, Venuceane™, ferulic acid, polydatin, silymarin, punica granatum extract, mango leaf extract, soliprin, catechin, hesperetin, astilbin, and DHC V; (b) optionally, one or more solubilizers; and (c) a cosmetically acceptable carrier; wherein the combination of (a), optional (b), and (c) alone, provide at least broad spectrum protection from both infrared (IR) radiation and visible light. UV filters can also optionally be included to provide additional protection from UV light.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: November 27, 2018
    Assignee: L'OREAL
    Inventors: Zhi Pan, Maolin Guo, Jean-Thierry Simonnet
  • Cosmetic compositions comprising ceramides and cholesterol
    Patent number: 10137073
    Abstract: The present disclosure relates to cosmetic compositions, typically in the form of an emulsion, comprising cholesterol, at least one ceramide, and oils. The compositions are particularly useful for supporting natural lipid barrier function of skin. Furthermore, the compositions treat skin dryness, skin damage, and the appearance of wrinkles, dark spots, and uneven skin texture. Also disclosed is a process for manufacturing the cosmetic compositions.
    Type: Grant
    Filed: January 2, 2016
    Date of Patent: November 27, 2018
    Assignee: L'OREAL
    Inventors: Joyce Ann De Lemos, Patricia Brieva, Donna McCann
  • Cosmetic composition and methods of use thereof
    Patent number: 10137074
    Abstract: The present invention relates generally to the field of cosmetics. More particularly, it concerns compositions that can be used to exfoliate, moisturize, or prepare skin for moisturization. In another aspect, the composition can be used as a cleanser to remove dirt, oil, grease, tars, etc. from surfaces.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: November 27, 2018
    Assignee: Mary Kay Inc.
    Inventors: Julia Collier, Michael Frushour, Kim Wilson
  • Cosmetic use of an extract of balanites almonds to improve hair strength
    Patent number: 10137075
    Abstract: The invention concerns the use of a cosmetic compound to improve hair strength, said cosmetic compound comprising as an active ingredient an extract of Balanites almonds.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 27, 2018
    Assignee: PIERRE FABRE DERMO-COSMETIQUE
    Inventor: Christel Fiorini Puybaret
  • Massage oil and method of manufacture
    Patent number: 10137076
    Abstract: A massage oil includes Virgin Olive oil; Bay leaves; St. John's Wort; Mugwort; Lavender flower; Chamomile flower; Yerba Santa; Arnica Flower; Bay essential oil; Vetivert essential oil; Chamomile essential oil; Ylang Ylang essential oil; and Lavender essential oil.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: November 27, 2018
    Inventor: Diane Sica
  • Cosmetic use of extract to protect skin from thermal stress
    Patent number: 10137077
    Abstract: Methods of protecting skin from damage due to cold thermal stress are disclosed. The methods include topically applying a composition that includes an Artemia salina extract from rehydrated Artemia salina cysts to skin at risk of damage from thermal stress, particularly from cold thermal stress or repeated temperature variations. The composition includes a physiologically acceptable medium for delivery of the Artemia salina extract.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: November 27, 2018
    Assignee: ISP Investments, LLC
    Inventors: Jean-Marie Botto, Valère Busuttil, Karine Cucumel, Neil Astles, Nouha Domloge
  • Methods for intravesical drug delivery and methods and systems for loading devices with drug tablets
    Patent number: 10137078
    Abstract: Systems and methods are provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas. The systems and methods may be used to load a drug delivery device that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets is positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: November 27, 2018
    Assignee: TARIS Biomedical LLC
    Inventors: Heejin Lee, Cheryl Larrivee-Elkins
  • Transdermal composition for treating pain
    Patent number: 10137079
    Abstract: Described is a transdermal ethosome composition for the treatment of pain. The transdermal ethosome composition comprises: an alcohol; a phospholipid; water; and a magnesium salt, a TRPV1 receptor agonist, or both a magnesium salt and a TRPV1 receptor agonist. The present compositions can be used to treat pain that is muscular, nociceptive or neuropathic in origin.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: November 27, 2018
    Assignee: CURA HEALTH INC.
    Inventor: Moheb Maalawy
  • Device and method for sustained release of antipsychotic medications
    Patent number: 10137081
    Abstract: A drug delivery device comprising a non-erodible, non-porous housing member defining a reservoir is provided. The reservoir is loaded with a dry formulation of a selected salt of a neuroleptic agent. The housing member has one or more porous partitions, where the pores of the partitions are sufficiently small to retain the insoluble powder particles within the reservoir yet large enough to allow diffusion of the active agent once the device is hydrated. A therapeutic dose of the drug is released from the device at a constant rate over a period of approximately 2-6 months.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: November 27, 2018
    Assignee: Delpor, Inc.
    Inventor: Gregory Alan Watkins
  • Hydrogel microparticle scaffold with gradients of degradability and methods thereof
    Patent number: 10137082
    Abstract: Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: November 27, 2018
    Assignee: Washington University
    Inventors: Donald L. Elbert, Jacob Roam
  • Ophthalmic preparations
    Patent number: 10137083
    Abstract: The present invention provides ophthalmic formulations containing cyclosporine, methods for preparing the formulation, and methods for using the formulation.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: November 27, 2018
    Assignee: SGN Nanopharma Inc
    Inventors: Robert Lee, Dinesh Shenoy
  • Use of bethanechol for treatment of xerostomia
    Patent number: 10137084
    Abstract: Bethanechol is administered topically, for the treatment of xerostomia.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: November 27, 2018
    Assignee: Acacia Pharma Limited
    Inventors: Nicola Cooper, Julian Clive Gilbert, Robert William Gristwood, Michael Grant Wyllie
  • Nanoemulsion for transdermal delivery and method of making the same
    Patent number: 10137085
    Abstract: The present invention relates to a nanoemulsion for transdermal delivery. The presently claimed invention provides chemical formulations for preparing a nanoemulsion, and the methods for preparing the nanoemulsion. The nanoemulsion has desirable particle size for efficient transdermal delivery, and doesn't involve any organic solvent which is harmful to human skin. The corresponding fabrication method is simple.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: November 27, 2018
    Assignee: Nano and Advanced Materials Institute Limited
    Inventors: Ngar Yee Huen, Sau Kuen Connie Kwok, Jinjie Xu, Chun Him Wong, Min Xiao
  • Lipid-derived neutral nanoparticles
    Patent number: 10137086
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: November 27, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Lipid-derived neutral nanoparticles
    Patent number: 10137087
    Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: November 27, 2018
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Braydon Charles Guild, Michael Heartlein
  • Therapeutic nanoparticles having EGFR ligands and methods of making and using same
    Patent number: 10137088
    Abstract: Provided herein in part is a therapeutic nanoparticle that includes a biocompatible polymer; a polymer—EGFR ligand conjugate, wherein the EGFR ligand is covalently bound directly or through a chemical linker to the polymer, and a therapeutic agent.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: November 27, 2018
    Assignee: Pfizer Inc.
    Inventors: Stephen E. Zale, Kevin Andrew McDonnell, Allen Thomas Horhota
  • Solvent extraction from biodegradable microparticles
    Patent number: 10137089
    Abstract: Embodiments may also include a system for reducing a solvent concentration in a plurality of microparticles. The system may include a solvent extraction tank. In the solvent extraction tank, a mixture including the plurality of microparticles and the solvent may be contacted with water to form an aqueous suspension. A first portion of the solvent may dissolve into the water of the aqueous suspension to reduce the solvent concentration in the plurality of microparticles. The system may also include a concentration unit in fluid communication with the solvent extraction tank. The concentration unit may further reduce the solvent concentration in the plurality of microparticles. A microparticle concentrate may be formed. The system may further include a washing unit. In the washing unit, the microparticle concentrate may be contacted with a washing solution and may form an amalgam of washed particles.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: November 27, 2018
    Assignee: Rezolute, Inc
    Inventor: Greg Bryden Sebring
  • Nozzle, apparatus, and method for producing microparticles
    Patent number: 10137090
    Abstract: A nozzle, an apparatus, and a method for producing dual-layer microparticles used as microcarriers. The nozzle includes a nozzle body having a first fluid passageway and a cover mounted to the nozzle body and having a second fluid passageway. A plurality of extension tubes is communicated with an end of the first fluid passageway and is spaced from each other. Each extension tube includes an outlet port distant to the first fluid passageway. A plurality of sleeves is communicated with the second fluid passageway. Each sleeve includes an opening distant to the second fluid passageway. Each extension tube extends into one of the sleeves. An outer wall of each extension tube is spaced from an inner wall of one of the sleeves. The outlet port of each extension tube is located between the second fluid passageway and the opening of one of the sleeves.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: November 27, 2018
    Assignee: Metal Industries Research & Development Centre
    Inventors: Cheng-Han Hung, Zong-Hsin Liu, Ying-Chieh Lin, Ming-Fang Tsai, Hai-Ching Tsou, Ying-Cheng Lu
  • Immediate/delayed drug delivery
    Patent number: 10137091
    Abstract: In one aspect, the present invention is concerned with a treatment where it is desired that an active agent is designed to be released immediately following administration and again at a time point some time after administration of the active agent. The present invention is particularly suited to administering an agent which may be released before sleep and while a subject is sleeping. As well as treating certain conditions by a particular regime, the invention also provides novel formulations for an immediate, followed by a delayed release of drug.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: November 27, 2018
    Assignee: UNIVERSITY OF STRATHCLYDE
    Inventors: Alexander Mullen, Howard Stevens, Sarah Eccleston
  • Double-layer tablet and preparation method thereof
    Patent number: 10137092
    Abstract: The invention discloses a double-layer tablet, wherein one layer has hole in which the ingredients of the other layer are filled; the number of said hole is 1-3, the diameters of the holes are 1-10 mm. Each layer of the double-layer tablet includes the active ingredients and the adjuvant materials and can be the rapid-release layer or sustained-release layer respectively. The preparation method: Preparing respectively a component I and a component II, both of them containing the active ingredients and the pharmaceutical excipients, and preparing the tablet having holes from component I; Forming the double-layer tablet composed of the component I layer and the component II layer after pressing said tablet having holes with the component II together; and filling the component II into the holes during compressing.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: November 27, 2018
    Inventor: Xiaoguang Wen
  • Milrinone controlled-release formulation
    Patent number: 10137093
    Abstract: The present invention relates to oral controlled-release formulations of 5-(pyridinyl)-2(1H)-pyridinone compounds and their use in the treatment of a subject with heart failure, a stage, class or manifestation of heart failure, or at risk of developing or exhibiting symptoms of heart failure. The formulations of the invention release the compounds in the range of between 0.1 ?g/kg body weight/minute and 20 ?g/kg body weight/minute.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: November 27, 2018
    Assignee: Cardiora Pty Ltd.
    Inventors: David Martin Kaye, Guy Krippner, Geetha Thanga Mariappan
  • Gastroretentive dosage system and process of preparation thereof
    Patent number: 10137094
    Abstract: The present invention relates to novel gastroretentive dosage systems, in particular, a floating capsule which releases the drug without any lag time and which remains buoyant for a sufficient period of time in the stomach. Further, the invention relates to the process of preparation thereof.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: November 27, 2018
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Varinder Kumar, Shavej Ahmad, Romi Barat Singh
  • Use of cannabinoids in the treatment of epilepsy
    Patent number: 10137095
    Abstract: The present disclosure relates to the use of cannabidiol (CBD) for the treatment of atonic seizures. In particular the CBD appears particularly effective in reducing atonic seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; Doose Syndrome; Aicardi syndrome; CDKL5 and Dup15q in comparison to other seizure types. The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: November 27, 2018
    Assignee: GW Pharma Limited
    Inventors: Geoffrey Guy, Stephen Wright, Alice Mead, Orrin Devinsky
  • Binge behavior regulators
    Patent number: 10137096
    Abstract: Methods and compositions utilizing 2-aminoindan derivatives collectively represented by Formula I as described and defined in the specification for regulating binge behavior, particularly binge drinking, are disclosed.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: November 27, 2018
    Inventor: Ezekiel Golan
  • Non-peptidic GAPDH aggregation inhibitor
    Patent number: 10137097
    Abstract: [Problem] Provided is a non-peptide compound which can be used as a GAPDH aggregation inhibitor. [Solution] Provided is a GAPDH aggregation inhibitor including as an active ingredient a compound represented by the chemical formula 1 wherein R1, R2, and R3 are each independently a hydrogen atom, a halogen atom, or an aliphatic hydrocarbon group having a carbon number of from 1 to 10, a polysulfurized derivative thereof, or a pharmaceutically acceptable salt thereof. The present compound has a GAPDH aggregation inhibitory activity to suppress intracerebral aggregation of various proteins involved in cerebral neurodegenerative diseases, thereby contributing to improvement in various brain neurological diseases associated with aggregation of these proteins such as Alzheimer's disease, Parkinson's disease, and cerebral infarction, and prevention of advanced seriousness of these diseases.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: November 27, 2018
    Assignee: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION
    Inventor: Hidemitsu Nakajima
  • Transdermal preparation
    Patent number: 10137098
    Abstract: Provided is a novel transdermal absorption preparation containing silodosin or tamsulosin, or salt thereof as an active ingredient, wherein the transdermal absorption preparation is capable of keeping a dissolved state for a long time, as well as has a high permeability to a skin, and can effectively and sustainably exert the transdermal absorbability. A transdermal absorption preparation containing the transdermal absorption preparation comprises an acrylic pressure-sensitive adhesive that comprises a copolymer of at least one (meth)acrylic acid monomer and at least one vinyl monomer and that contains a carboxyl group, and at least one transdermal absorption promoting agent selected from the group consisting of oleyl alcohol, lauryl alcohol, and lauromacrogol.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 27, 2018
    Assignee: TEIKOKU SEIYAKU CO., LTD.
    Inventors: Satoshi Kawakami, Taiki Shibata, Manabu Sogabe
  • Activation of AMP-protein activated kinase by oxaloacetate compounds
    Patent number: 10137099
    Abstract: The present invention relates to oxaloacetate compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds, preserving said compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, obesity, cardiovascular disease, Alzheimer's disease, and cancer.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: November 27, 2018
    Inventor: Alan B Cash
  • Administration of serine protease inhibitors to the stomach
    Patent number: 10137100
    Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: November 27, 2018
    Assignees: The Regents of the University of California, Inflammagen, LLC
    Inventors: Geert W. Schmid-Schonbein, Yung-Tsai (Andrew) Lee, Jeng Wei
  • Alkylamido compounds and uses thereof
    Patent number: 10137101
    Abstract: Disclosed herein are compounds that may be specific to PPAR and/or EGF receptors, and methods of making and using same.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: November 27, 2018
    Assignee: Nogra Pharma Limited
    Inventors: Sergio Baroni, Salvatore Bellinvia, Francesca Viti
  • Oligomeric forms of 3-hydroxybutyrate
    Patent number: 10137102
    Abstract: The present invention relates to medicaments based on oligomeric forms of 3-hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1 and 2.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: November 27, 2018
    Inventors: Anna Maria Pirttilä, Janne Koskimäki, Sampo Mattila, Marena Kajula, Juho Hokkanen, Bruce Campbell
  • Compositions and methods for the treatment of fatty acid metabolism disorders
    Patent number: 10137103
    Abstract: Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: November 27, 2018
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Harry Ischiropoulos, Paschalis-Thomas Doulias
  • Combination therapy with an anti-hyaluronan agent and therapeutic agent
    Patent number: 10137104
    Abstract: Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 27, 2018
    Assignee: Halozyme, Inc.
    Inventors: Daniel C. Maneval, H. Michael Shepard, Curtis B. Thompson
  • Combination treatment protocol
    Patent number: 10137105
    Abstract: The present disclosure provides a combination and a method for treating chronic lymphocytic leukemia (CLL).
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: November 27, 2018
    Assignee: Bionomics Limited
    Inventors: Alan R. Eastman, Darcy Bates, Gabriel Kremmidiotis
  • Compositions and methods to treat niemann-pick disease
    Patent number: 10137106
    Abstract: The present disclosure is directed to compositions comprising bryostatin-1, and methods comprising administering a composition comprising bryostatin-1, to treat Niemann-Pick Type C in a subject in need thereof.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: November 27, 2018
    Assignee: Cognitive Research Enterprises, Inc.
    Inventor: Daniel L. Alkon
  • Substituted phenylpyrrolecarboxamides with therapeutic activity in HIV
    Patent number: 10137107
    Abstract: Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: November 27, 2018
    Assignees: New York Blood Center, Inc., National Institutes of Health
    Inventors: Asim Kumar Debnath, Francesca Curreli, Peter D. Kwong, Young Do Kwon
  • Nutritional composition useful in the treatment of IBD patients
    Patent number: 10137108
    Abstract: Compositions and methods are provided that are useful in the treatment of inflammatory bowel disease (IBD) patients. The Compositions and methods are suitable in the prevention or postponement of a relapse in inflammatory bowel disease patients.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 27, 2018
    Assignee: Nestec S.A.
    Inventors: Stephanie Blum-Sperisen, Magali Faure, Denis Breuille, Emil Chuang
  • Carbazole compounds and therapeutic uses of the compounds
    Patent number: 10137109
    Abstract: Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: November 27, 2018
    Assignee: INCURON, INC.
    Inventors: John Tucker, Sergey Sviridov, Leonid Brodsky, Catherine Burkhart, Andrei Purmal, Katerina Gurova, Andrei Gudkov
  • 1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors
    Patent number: 10137110
    Abstract: The present invention relates to benzimidazol-2-amines of general formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: November 27, 2018
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Hartmut Rehwinkel, Sonja Anlauf, Duy Nguyen, Olaf Panknin, Marcus Bauser, Katja Zimmermann, Stefan Kaulfuss, Roland Neuhaus, Paul Matthew Blaney, Gianna Toschi
  • Drug compositions comprising an anti-parasitic and proton pump inhibitor
    Patent number: 10137111
    Abstract: Described herein are pharmaceutical compositions including a proton pump inhibitor and an antiparasitic drug. In some embodiments, the compositions can be formulated as a non-solid for oral administration. The compositions can be used to treat gastrointestinal conditions. Methods of treatment using the compositions are also described.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: November 27, 2018
    Assignee: Adamis Pharmaceuticals Corporation
    Inventors: David Clayton Sutherland, James Kyle Zorn, Dennis J. Carlo