Abstract: Disclosed is a compound of formula (I) or (II) in which R1-R4, R1?-R5?, Z1+-Z4, and Z1?-Z4? are as described herein. Also disclosed are a 89Zr- or 90Nb-containing complex of a compound of formula (I) or (II) and a method for obtaining a diagnostic image, such as a positron emission tomography (PET) image.

Abstract: A disinfecting system including a delivery unit having a dental instrument holder, a dental instrument engagable with the dental instrument holder, a fluid supply line fluidly coupled to the dental instrument to provide fluid to the dental instrument, and a disinfecting device in fluid communication with at least one of the supply lines and the dental instrument.

Abstract: A sterilization container includes a floor. A first sidewall is connected to a first side of the floor and a second sidewall is connected to a second side of the floor wherein each of the first and second sidewalls has an elongated blind cavity formed along a length thereof. A first hinge is positioned partially within the blind cavity of the first sidewall, and a second hinge is positioned partially within the blind cavity of the second sidewall, wherein each of the first and second hinges are movable along a length of the first and second blind cavities, respectively. A lid is connected between the first and second hinges and is positionable between a first position substantially parallel with the floor on a third side of the floor, and a second position substantially parallel with the floor on a fourth side of the floor.

Abstract: An organic waste odor absorbing composition for the absorption of odors resulting from decomposing organic waste is disclosed. The composition comprises dried carbon and/or silica based matter, either natural or synthetic. The carbon-based materials consist of 35% to 85% holocellulose and 8% to 30% lignin. The silica-based materials consist of 40% to 80% silica. The materials may be mechanically sized to allow for adequate airflow and surface area exposure to the organic waste.

Abstract: A system for disinfecting a fluid containing contaminants (chemical and biological) includes a plurality of photocatalytic particles secured to a substrate which contacts the fluid to be disinfected. An agitator for imparting translation and/or vibrational movement is in operational communication with the substrate to increase the contact of photocatalytic particles with contaminants in the fluid. The system can include a source of photons having a wavelength corresponding to band gap energy of the photocatalytic particles to illuminate the substrate. Although the invention can be used to disinfect air in air supply registers of a heating, ventilating and air conditioning system, or in air ducts, the disinfection of any fluid (including water) is contemplated.

Abstract: A method of sterilizing a preform includes steps of: sterilizing bacteria adhering to a preform (1) made of resin by gasifying a sterilizer, discharging a sterilized gas (G) from a nozzle (6) toward a preform (1), now traveling, so as to adhere to the preform (1); activating the sterilizer adhering to the preform (1) by blasting hot air (P) to the preform; and sterilizing bacteria adhering to the preform, and removing the sterilizer adhering to the preform (1), wherein the above steps are performed sequentially in order. According to the above-mentioned steps, the sterilizer does not enter a blow-molding machine.

Abstract: A disinfection system of a contact lens comprising immersing the contact lens in a disinfecting solution containing hydrogen peroxide in a concentration of 1 to 10% and neutralizing the hydrogen peroxide in the disinfecting solution through contact with a metal catalyst, where the disinfecting solution contains an organic carboxylic acid or a salt of the organic carboxylic acid, the organic carboxylic acid having a structure in which a hydroxyl group and a carboxyl group are bonded to one carbon atom; the disinfecting solution is adjusted to have a pH of 6 to 8; and the disinfecting solution after the neutralization is adjusted to have an osmotic pressure of 250 to 350 mOsm.

Abstract: An absorbent layer for moderating blood flow from a wound has a non-woven fabric layer of water-insoluble chitosan fibers having a coating of water-absorbent starch on at least one face of the fabric layer. The coating of water-absorbent starch penetrates into the fabric layer from a first surface over the chitosan fibers to a depth of at least 25% of the fabric layer of chitosan fibers. The chitosan fibers have average diameters of from 5 to 30 micrometers. The average weight of starch/chitosan may decrease from the first surface from which the starch has penetrated into the fabric to the depth of at least 50% of the fabric layer. The starch may be modified to include hydrophilic groups into or onto molecular chains of the starch.

Abstract: The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.

Abstract: The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

Abstract: A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces.

Abstract: A scaffold comprising an aligned fiber. The invention further relates to a scaffold comprising one or more electrospun fibers wherein a fast Fourier transform (FFT) analysis result of the fibers have adjacent major peaks with about 180? apart from each other. Methods for promoting differentiation of stem cells into osteoblasts, chondrocytes, ligament or tendon, the method comprising culturing the cells on the scaffold or aligned fiber in conditions suitable for the cell differentiation.

Abstract: Disclosed are products and methods for treating soft tissue injuries. The provided methods include the production of processed or cryopreserved microvascular tissue. Also provided are products and methods of using processed or cryopreserved microvascular tissue for the treatment of soft tissue injuries.

Abstract: Articles-of-manufacturing comprising an object having a surface and at least a first layer of a first therapeutically active agent being deposited onto at least a continuous portion of the surface, wherein at least 50 weight percents of the first layer is the first therapeutically active agent in a crystalline form are disclosed. Methods utilizing such articles-of-manufacturing for treating medical conditions are also disclosed. Processes of preparing the articles-of-manufacturing by contacting a surface of the object with a solution containing the therapeutically active agent, without cooling the surface to a temperature below a temperature of the solution, are also disclosed.

Abstract: Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.

Abstract: An embodiment of the invention is directed to a bone marrow aspiration device comprising a plurality of syringes, each of which operates in a series of sequential steps to obtain bone marrow of high quality and therapeutic value, i.e., having a high mesenchymal stem cell (“MSC”) MSC/ml number. In certain embodiments, a syringe may be used along with a collection vessel or with a second syringe. A further embodiment of the invention is directed to a method for using the bone marrow aspiration device as set forth herein.

Abstract: An apparatus, system, and method for treating an incisional wound having incisional walls is disclosed. The apparatus includes a conduit having a first end for receiving reduced pressure and a second end. The apparatus further includes a scaffold. The scaffold has opposing surfaces for positioning adjacent the incisional walls and is fluidly coupled to the second end of the conduit for receiving the reduced pressure. The scaffold is generally elongated in shape and has a thickness between the opposing surfaces that is sufficiently thin for positioning within the incisional wound. The apparatus further includes an internal manifold that has a primary flow channel extending generally longitudinally within the scaffold and between the opposing surfaces of the scaffold. The internal manifold is fluidly coupled to the second end of the conduit. The application of the reduced pressure through the scaffold and the internal manifold induces tissue apposition between the incisional walls.

Abstract: This document relates to materials and methods for circulatory bypass of a ventricle in the heart of a mammal. For example, materials and methods for bypassing a permanently or temporarily impaired left ventricle in the heart of a mammal (e.g., a human) are provided.

Abstract: The present invention provides a skin attachment device for use with implantable medical devices which extend through the skin for prolonged durations.

Abstract: A circulatory assist apparatus comprising: an inflatable pumping balloon having a proximal end joined to an elongated balloon catheter, the balloon catheter having a distal end joined to the pumping balloon and a proximal end, separated from the distal end by a length sufficient to extend from within a circulatory lumen to the outside of a patient's body, for receiving positive and negative pressure pulses from a pump to inflate and deflate the pumping balloon; and a radially expandable frame, mounted on one of a segment extending distally from the pumping balloon, the balloon catheter, and a sleeve tube surrounding the balloon catheter. The expandable frame is manipulate to expand within the circulatory lumen, and functions to space apart the inflatable balloon from the circulatory lumen, having a first diameter in a collapsed configuration for intraluminal delivery and a second, larger diameter in an expanded configuration achieved by said manipulation.

Abstract: A TET system is operable to vary an amount of power transmitted from an external power supply to an implantable power unit in accordance with a monitored condition of the implantable power unit. The amount of power supplied to the implantable power unit for operating a pump, for example, can be varied in accordance with a cardiac cycle, so as to maintain the monitored condition in the power circuit within a desired range throughout the cardiac cycle.

Abstract: A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system.

Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.

Abstract: An embodiment of a peritoneal dialysis system includes an enclosure, a door hingedly attached to the enclosure, a stepper motor housed by the enclosure, a solid pump piston in operable communication with the stepper motor and including a solid pump shaft attached to or integrally formed with a solid pump head, and a disposable unit contacting the enclosure and the door. The disposable unit includes a moveable membrane operable with the solid pump head. The stepper motor is configured to move the solid pump head towards and away from the disposable unit. The system further includes a position detection apparatus operable with the stepper motor and located to provide an output indicative of a position of the solid pump head relative to a reference position.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: The present invention relates to a needle arrangement for an injection device. The needle arrangement is made up from needle cannula which is mounted such that a distal part having a distal tip extends in a distal direction. Further, a telescopically movable shield carrying a cleaning chamber surrounds at least the tip of the needle cannula between injections such that the tip of the needle cannula is maintained inside the cleaning chamber between subsequent injections. The cleaning chamber is at least distally provided with a pierceable septum through which the needle cannula penetrates during injections. For guiding the needle cannula during injections a telescopically movable tube is provided. During injections the distal end of the telescopically movable tube at least partly penetrates the distal septum.

Abstract: A flip-open multi-pack assembly which contains a plurality of new pen needles via a rectangular or tube-shaped, hinged shell housing, wherein new pen needles are stored in a plurality of user accessible openings each having a sterility barrier formed by covers that cover the non-patient end of the openings where the new pen needles are contained. Used pen needles are returned and stored in openings accessible by rotatably opening the shell housing. One or more of the openings within first and second opposite ends of the housing shell include a slidable internal holder configured to releasably secure the inner shield of the new pen needle, and subsequently be pulled forward when the new pen needle is removed and locked at a forward position, to create an interior space, accessible from an opposite end when the hinged housing is opened, for a used pen needle to be inserted and stored.

Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.

Abstract: The invention is related to a dispense interface for a drug delivery device for delivering at least two drug agents, comprising at least two two-ended flow regulation structures and a confluence, wherein each flow regulation structure comprises a fluid inlet opening at a first end, wherein each flow regulation structure comprises a fluid outlet opening connected to the confluence at a second end of the respective flow regulation structure and wherein at least one of the two-ended flow regulation structures comprises a capillary fluid channel. The invention is further related to a drug delivery device for delivering at least two drug agents comprising a dispense interface of the aforementioned kind, to a method for delivering at least two drug agents through an injection means of a drug delivery device and to a method for manufacturing a dispense interface of the aforementioned kind.

Abstract: An automated insertion assembly includes a first dermal perforation assembly configured to releasably engage a first subdermal device. A first actuation assembly is configured to drive the first dermal perforation assembly into a user's skin to a first depth and drive the first subdermal device into the user's skin to a second depth. The second depth is greater than the first depth.

Abstract: A portable therapeutic fluid delivery device with a flow detector comprising a heating element and two temperature sensors is presented. Upon activation of the heating element, a flow condition of the fluid inside the delivery tube is determined based on a signal provided by the temperature sensors. A temperature gradient within the therapeutic fluid is detected. The determined flow condition can be one of: air bubbles within the delivery tube, occlusion within the delivery tube, or leakage within the delivery tube. The device can have two parts, for example, a reusable part and a disposable part. Upon pairing of these parts, the heating element and the temperature sensors touch the delivery tube.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary infusion device includes a motor operable to deliver fluid to a body of a user, a first control module, and a second control module. The first control module and the second control module are coupled to one another. The first control module enables input power for the motor in accordance with a handshaking sequence of communications between the first control module and the second control module and provides a dosage command to the second control module, with the second control module operating the motor using the input power based on the dosage command in accordance with the handshaking sequence of communications.

Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.

Abstract: A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.

Abstract: Some embodiments of an infusion pump assembly may be equipped with one or more components to facilitate wireless operation of an infusion pump via a user-operated mobile device. In some embodiments, the mobile device and/or the infusion pump may prompt the user to confirm acceptance of a wirelessly communicated command to prevent an operation by the infusion pump (e.g., a dispensation of medicine) that is not desired by the user.

Abstract: A method, apparatus, and system are provided for mucous membrane therapy. The method includes receiving at least one body signal from a patient; detecting a condition of the patient based on the body signal; and administering the therapy to at least one of a mucous membrane or a serous membrane of the patient. A medical device system configured to implement the method is provided. A computer-readable storage device for storing instructions that, when executed by a processor, perform the method is also provided.

Abstract: The present invention relates to an autoinjector device (10) for use in combination with a syringe (30), said syringe comprising a movable plunger; a needle; and a tubular needle shield (34). The claimed autoinjector device (10) comprises: an elongated housing having a proximal (11) and a distal end (12); a drive mechanism; a syringe holder (40) in order to support the fragile syringe and to prevent damage to the syringe. The invention furthermore relates to a method for assembly of the autoinjector device according to the invention.

Abstract: The priming configuration comprises a piston rod (1), a bung (2), which is provided to be driven by the piston rod, and a movable element (5), which is engaged with the piston rod. The movable element is arranged to be movable in a predefined direction (10) with respect to the piston rod by a user of the drug delivery device. A movement of the movable element in the predefined direction advances the piston rod in a further direction (11), providing a priming of the drug delivery device before use. The predefined direction may especially be transverse to the further direction, and the further direction may especially be directed from the piston rod towards the bung (2). A gap (12) or clearance between the piston rod (1) and the bung (2) can thus be removed, and the stiction of the bung (2) to the cartridge (3) can be reduced.

Abstract: A syringe includes a gasket, a barrel, and a plunger. The plunger includes a helical rib provided on an outer surface of a head portion, and the gasket comprises a helical valley portion for threadedly engaging with the helical rib, a plunger-retaining annular rib, and an accommodation portion for a part of the plunger at which the helical rib is formed. The annular rib comprises a rib absent portion for guiding, to the accommodation portion, the helical rib reaching the annular rib as threaded engagement is advanced between the plunger and the gasket. The helical rib comprises an entrance-restricting terminal end portion for restricting the entrance of the helical rib into the rib absent portion after the part of the plunger 4 at which the helical rib is formed is stored in the accommodation portion 32 of the gasket.

Abstract: An assembly for a drug delivery device is provided, the assembly having a compression spring, wherein the compression spring is compressed during the setting of a dose of a drug. The assembly further comprises a sleeve member, wherein the compression spring is in direct contact with the sleeve member and wherein the compression spring and the sleeve member are configured such that a relaxation of the compression spring effects a rotational and an axial movement of the sleeve member in a proximal direction, thereby causing a dispensing of a dose from the drug delivery device.

Abstract: The invention relates to a pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug. A piston rod having an external thread is driven forward by a rotatable piston rod guide engaging the piston rod. The piston rod guide is rotated by a torsion spring encompassed between the housing and the piston rod guide. A scale drum having a thread engaging the external thread of the piston rod is provided, and the scale drum is rotated up and down the piston rod by a proximal located rotatable dose setting member cooperating with the scale drum. The scale drum thus move helically when rotated as the piston rod is held inrotatable during dose setting.

Abstract: A driving and dosing device for an injection device for administering a liquid product, in particular a medication, wherein a product dose to be administered can be set by means of the driving and dosing device, comprising: a) a housing, b) a dose indicating element, around the circumference of which a dose scale is arranged, c) a pointing device and a (d) dosing element that can be gripped in particular by the user of the driving and dosing device, wherein the dose indicating element can be rotated, in particular screwed, relative to the pointing device and about an axis of rotation (L) and a value of the dose scale that corresponds to the set dose can be read by means of the pointing device, in order to set the dose to be administered by rotating the dosing element relative to the pointing device, and e); a discharge spring, which stores the energy required for discharging the product, wherein the discharge spring is loaded by means of rotation of the dosing element.

Abstract: Drug delivery device adapted to receive a cartridge, comprising a drive tube with an inner thread, a motor assembly comprising a drive shaft and being adapted to be received inside the drive tube, a drive member attached to the drive shaft and with an outer thread in engagement with the drive tube inner thread. The drive tube is arranged axially displaceable but non-rotational relative to the motor assembly, whereby rotation of the drive member results in axial, non-rotational displacement of the drive tube. To provide flexibility the drive shaft is connected to the drive member via a first flexible joint, and the motor assembly proximal portion is connected to a support structure via a second flexible joint.

Abstract: An autoinjector includes a case having a rib, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case and adapted to hold a medicament container, and a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier. The needle shroud is movable between a first extended position, a retracted position and a locked second extended position. The carrier is movable from a first axial position to a second axial position relative to the case. The collar abuts the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar disengages the rib when the needle shroud is in the retracted position and the carrier is in the second axial position.

Abstract: An autoinjector includes a case adapted to hold a medicament container, a needle shroud telescopically coupled to the case, and a plunger slidably disposed in the case. The needle shroud is movable between a first extended position, a retracted position, and a second extended position relative to the case. The plunger is movable between a proximal position, an intermediate position, and a distal position relative to the case. When the plunger is in the intermediate position and the needle shroud is in the retracted position, the plunger abuts the case to prevent the needle shroud from returning to the extended position. When the plunger is in the distal position and the needle shroud is in the second extended position, the plunger abuts the case to prevent the needle shroud from returning to the retracted position.

Abstract: Presented herein are various systems, methods, and apparatuses for heating infusate by an induction heater e.g., an electromagnetic heater, and storing thermal energy in a reservoir of thusly heated infusate. In certain embodiments, a system includes a reservoir for containing an infusate, a fluid heater, a diversion valve, a patient line, and a recirculation line.

Abstract: The present invention relates to a pharmaceutical injection device, and it is an object thereof to prompt the user to replace the injection needle as needed. To achieve this object, the present invention is configured such that a needle detector switch 8 that directly or indirectly detects the mounting of an injection needle to a pharmaceutical syringe 5 is provided to a main case 2, this needle detector switch 8 is connected to a controller 21, and the controller 21 displays on a display component 19 an injection needle removal message that directly or indirectly prompts the user to remove an injection needle 6 from the pharmaceutical syringe 5 when the mounting of the injection needle 6 to the pharmaceutical syringe 5 has been detected by the needle detector switch 8 in the switching off the a power switch 16.

Abstract: A nebulization structure includes a carrier unit, a vibration unit, a nebulization unit and a position-limiting unit. The carrier unit has a first carrier portion and a first surrounding portion extended from an outer perimeter of the first carrier portion, and the first carrier portion has a through hole. The vibration unit includes an annular vibrating sheet disposed on the carrier unit. The nebulization unit is disposed on the first carrier portion, and the nebulization unit has a plurality of micro holes communicated with the through hole. The position-limiting unit has a first position-limiting portion disposed on the nebulization unit and a second position-limiting portion extended from an outer perimeter of the first position-limiting portion and along the first surrounding portion. The nebulization unit is positioned between the first carrier portion and the position-limiting unit, and the first position-limiting portion has an opening for exposing the micro holes.

Abstract: The present nebulizer kit has a case body having a wall surface with a linear portion. The wall surface can serve as a barrier to change positively toward an aerosol discharge port a stream of aerosol flowing out from an external air introduction path in a direction away from the aerosol discharge port.

Abstract: An inhalator includes a housing with first and second compartments, and a substance. The second second compartment has an air entry port, the inhalator has a first end proximal to the first compartment and second end proximal to the second compartment, and the inhalation part is at the second end. The first compartment stores a substance and has in an inoperative state of the inhalator sealing bodies to define a sealed chamber for containing a substance. The bodies are movable together with the substance from the first compartment into the second compartment to define an inoperative state of the inhalator. Air enters through the air entry port and takes up, such as by evaporation, the substance contained in the second compartment. A release device moves the bodies into the second compartment and allows the air to flow to the air entry port in the operative state.