Abstract: This invention provides methods, compositions, and kits relating to detecting donor cell-free DNA in the circulation of a transplant recipient for the early identification of transplant rejection or for detection of damage to transplant cells.

Abstract: In one aspect, the invention provides methods of identifying genetic mutations that are associated with ataxic neurological disease. The methods comprise identifying a difference between a nucleic acid sequence of a protein kinase C gamma gene from a mammalian subject exhibiting ataxia and a nucleic acid sequence of a protein kinase C gamma gene from a subject which is not exhibiting ataxia, wherein the difference is a genetic mutation associated with ataxic neurological disease. In another aspect, isolated nucleic acid molecules encoding protein kinase C gamma missense mutations are provided. In another aspect, a method of screening a subject to determine if the subject has a genetic predisposition to develop an ataxic neurological disease is provided. In another aspect, the invention provides kits for determining susceptibility or presence of ataxic neurological disease in a mammalian subject.

Abstract: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital analysis is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies do not present a mutational change in sequence, and are merely a change in the number of chromosomes, it has not been possible to detect them in a fetus without resorting to invasive techniques such as amniocentesis or chorionic villi sampling. Digital amplification allows the detection of aneuploidy using massively parallel amplification and detection methods, examining, e.g., 10,000 genome equivalents.

Abstract: The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products.

Abstract: The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.

Abstract: Recent large-scale analyses have demonstrated that the genomic landscape of human cancer is complex and variable among individuals of the same tumor type. Such underlying genetic differences may in part be responsible for the varying therapeutic responses observed in cancer patients. To examine the effect of somatic genetic changes in colorectal cancer on sensitivity to a common targeted therapy, we performed complete exome sequence and copy number analyses of 129 tumors that were KRAS wild-type and analyzed their response to anti-EGFR antibody blockade in patient-derived tumorgraft models. In addition to previously identified genes, we detected mutations in ERBB2, EGFR, FGFR1, PDGFRA, and MAP2K1 as potential mechanisms of primary resistance to this therapy. Alterations in the ectodomain of EGFR were identified in patients with acquired resistance to EGFR blockade.

Abstract: The present invention relates to the use of ZNF532 inhibitors for the treatment of cancer, in particular cancer with cells that express the ZNF532 protein or harbor the ZNF532-NUT fusion gene. In some embodiments, the cancer is selected from the group consisting of NUT midline carcinoma (NMC), Ewing sarcoma, and head and neck squamous cell carcinoma.

Abstract: Disclosed are methods of diagnosing whether a subject is at risk of developing breast cancer comprising measuring the level of R-loop in a biological sample. Also disclosed are methods of treating breast cancer in a subject comprising administering to said subject a therapeutically effective amount of a given therapeutic when the subject is diagnosed with increased risk of developing breast cancer by the steps that include measuring the level of R-loop in a biological sample. The measured level of R-loop in a biological sample can be compared to a control sample from a non-BRCA mutation carrier. Disclosed are methods of treating a subject having an increase in breast epithelium R-loop comprising administering a treatment to the subject that reduces or eliminates R-loop, wherein the subject is a BRCA1 mutation carrier.

Abstract: A prognostic method, and a kit, for determining the risk of relapse of renal cancer of the clear cell renal carcinoma type, stages I and II, in a human subject; comprised of: (a) determining, in a tumor sample (biopsy) from the human subject, the levels of expression of the microRNAs hsa-miR-223, hsa-miR-103, hsa-miR-107, hsa-miR-425, hsa-miR-340, hsa-miR-130b, hsa-miR-652, hsa-miR-214, and hsa-miR-204; (b) determining a value which depends on the levels of expression of the microRNAs; and (c) determining the risk of relapse in renal cancer of the clear cell renal carcinoma type, in stages I and II, in the said human subject, by comparing the value obtained in step (b) with a cut-off value.

Abstract: The present invention relates to methods of using HEATR1 expression levels for guiding chemotherapy treatment of pancreatic cancer. In particular, measuring lower HEATR1 expression in pancreatic cancer is associated with resistance to the use of certain chemotherapy treatments such that by changing the treatment a better prognosis may be obtained for the patient. Further, lower HEATR1 expression is related to a poorer long-term prognosis of pancreatic cancer patients thus measuring an increase or maintenance/decrease during treatment may be useful for predicting treatment response.

Abstract: Novel ALK and NTRK1 fusion molecules and uses are disclosed.

Abstract: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the genomic locus, to produce an amplified sample, where: i. the amplifying is done using a first primer and a second primer; and ii. the first primer comprises a 3? terminal nucleotide that base pairs with the point mutation and also comprises a nucleotide sequence that is fully complementary to a sequence in the locus with the exception of a single base mismatch within 6 bases of the 3? terminal nucleotide; and b) detecting the presence of said product in said amplified sample using a flap assay that employs an invasive oligonucleotide. A kit for performing the method is also provided.

Abstract: Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

Abstract: The present invention generally relates to inhibitor compounds and their use to selectively kill a class of cancer cells. Methods and means related to the treatment of cancers which overexpress the MYC family of oncogenes using Rho-associated protein kinase inhibitors, such as dimethylfasudil, which have shown to elicit cellular apoptosis, are provided herein.

Abstract: The present invention relates in general to the field of colorectal cancer detection, and more particularly, to plasma microRNAs for the detection of early colorectal cancer.

Abstract: Methods for predicting palm oil yield of a test oil palm plant are disclosed. The methods comprise determining, from a sample of a test oil palm plant of a population, at least a first SNP genotype, corresponding to a first SNP marker, located in a first QTL for a high-oil-production trait and associated, alter stratification and kinship correction, with the high-oil-production trait with a genome-wide-log10(p-value) of at least 4.0 in the population or having a linkage disequilibrium r1 value or at least 0.2 with respect to a first other SNP marker linked thereto and associated, alter stratification and kinship correction, with the high-oil-production trait with a genome-wide-log10(p-value) of at least 4.0 in the population. The methods also comprise comparing the first SNP genotype to a corresponding first reference SNP genotype and predicting palm oil yield or the test plant based on extent or matching of the SNP genotypes.

Abstract: Disclosed are non-naturally occurring zebrafish, such as transgenic zebrafish, which comprise a mutation in the rhodopsin (rho) gene. Also disclosed are methods of identifying compounds useful in treating retinal-specific defects and disorders, such as degeneration. Further disclosed are methods of identifying mutations in the rhodopsin gene that can cause retinal-specific defects.

Abstract: The invention relates to an isothermal-based dual functional oligonucleotide containing quencher and reporter dye for an isothermal nucleic acid amplification and a method for nucleic acid amplification and measurement using the same. The present invention is directed to a method capable of obviating the need for an additional oligonucleotide, in addition to four to six types of oligonucleotides for a nucleic acid amplification reaction of LAMP, detecting the amount of fluorescence according to the amplification of the nucleic acid of target gene-specific sequence for DNA and RNA, enabling the detection also after the completion of the reaction, and detecting the amount of fluorescence in real-time. Therefore, the present invention allows simultaneous multiple tests by measuring the amount of fluorescence in one tube after the completion of the reaction or in real time while varying the reporter dye according to the target gene.

Abstract: Nucleic acid oligomers specific for human parvovirus genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus genotypes 1, 2 and 3 nucleic acid in biological specimens is disclosed. Compositions for amplifying and detecting the presence of human parvovirus genotypes 1, 2 and 3 genomic DNA in human biological specimens are disclosed.

Abstract: Disclosed are methods for detecting a target nucleic acid in sample, which include contacting the sample with an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction, an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to the target nucleic acid; a polymerase; and an endonuclease capable of nicking the endonuclease recognition site. The disclosure also provides compositions and kits comprising an oligonucleotide having a hairpin structure, where the oligonucleotide includes, in the 5? to 3? direction an arbitrary sequence, an endonuclease recognition site for a nicking reaction, a sequence complementary to the arbitrary sequence, and a sequence complementary to a target nucleic acid.

Abstract: All of a cast-iron or cast-copper stave cooler's weight is supported inside a furnace containment shell by single gas-tight steel collar on the backside. All the coolant piping in each cooler has every external connection collected and routed together through the one steel collar. A wear protection barrier is disposed on the hot face. Such is limited to include at least one of horizontal rows of ribs and channels that retain metal inserts or refractory bricks, or pockets that assist in the retention of castable cement and/or accretions frozen in place from a melt, or an application of an area of hardfacing that is welded on in bead, crosshatch, or weave pattern.

Abstract: A method of producing an article selected from a titanium article and a titanium alloy article comprises melting feed materials with a source of hydrogen to form a molten heat of titanium or a titanium alloy, and casting at least a portion of the molten heat to form a hydrogenated titanium or titanium alloy ingot. The hydrogenated ingot is deformed at an elevated temperature to form a worked article comprising a cross-sectional area smaller than a cross-sectional area of the hydrogenated ingot. The worked article is dehydrogenated to reduce a hydrogen content of the worked article. In certain non-limiting embodiments of the method, the dehydrogenated article comprises an average ?-phase particle size of less than 10 microns in the longest dimension.

Abstract: A high-strength bolt is provided that has high strength and excellent hydrogen embrittlement resistance characteristics. A bolt according to this invention has a chemical composition consisting of, in mass %, C: 0.22 to 0.40%, Si: 0.10 to 1.50%, Mn: 0.20 to less than 0.40%, P: 0.020% or less, S: 0.020% or less, Cr: 0.70 to 1.45%, Al: 0.005 to 0.060%, Ti: 0.010 to 0.045%, B: 0.0003 to 0.0040%, N: 0.0015 to 0.0080% and O: 0.0020% or less, with a balance being Fe and impurities, and satisfying Formula (1) and Formula (2), and with the high-strength bolt having a tensile strength of 1000 to 1300 MPa. 0.50?C+Si/10+Mn/5+5Cr/22?0.85??(1) Si/Mn>1.0??(2) Where, a content (mass %) of a corresponding element is substituted for each symbol of an element in Formula (1) and Formula (2).

Abstract: A double row tapered roller bearing includes: an outer ring having an annular shape; an inner ring disposed on an inner circumferential side of the outer ring and having an annular shape; and rollers. The inner ring has an outer circumferential surface facing the outer ring and having two rows of grooves having a bottom surface serving as a raceway surface. The rollers are tapered rollers disposed in the grooves in contact with the raceway surface of the inner ring and are also in contact with the outer ring. At outer circumferential surface of the inner ring, a region adjacent to the groove includes a hardened region extending from the inner peripheral surface of the groove to the region adjacent to the groove, and an unhardened region located at a position farther from the groove than the hardened region and being smaller in hardness than the hardened region.

Abstract: Provided are a method for deriving a cooling time when quenching a steel material, a method for quenching a steel material and a method for quenching and tempering a steel material. The method for deriving a cooling time comprises: step A of cooling a test specimen heated to a cooling initiation temperature Ts under a cooling condition C and measuring the cooling time t until the temperature of a center portion of the test specimen reaches a cooling termination temperature Te; step B of determining a function f which is defined by t=f(V/S) and which is satisfied by data including the volume V, the surface area S and the cooling time t of the test specimen obtained in step A; and step C of substituting the volume V1 and the surface area S1 of the shape F1 of a steel material to be actually quenched in the relational expression t=f(V/S), and calculating a cooling time t1.

Abstract: A process for leaching a value metal from a titaniferous ore material comprising the step of leaching the ore material at atmospheric pressure with a lixiviant comprising magnesium chloride and hydrochloric acid is disclosed. Iron and titanium are leached into solution. Iron in the ferric state may be separated from titanium in solution using extraction with alkyl ketone. More effective separation of titanium with lower contamination with iron is obtained.

Abstract: The invention relates to a method for the recovery of precious metal from materials containing precious metal, said method comprises the following steps of: A) bringing the materials containing the precious metal into contact with an oxidizing agent, B) bringing the material containing the precious metal into contact with a reducing agent. Said method offers the possibility of recovering precious metal in a simple manner and in high purity from secondary materials.

Abstract: An operation method of a copper-smelting furnace is characterized by including supplying an Fe metal source into a copper-smelting furnace together with a feeding material including copper concentrate and a flux, the copper concentrate including Al, the Fe metal source including an Fe metal of 40 mass % to 100 mass %.

Abstract: A die-casting magnesium alloy. The die-casting magnesium alloy comprises, by mass percent, 1% to 5% of La, 0.5% to 3% of Zn, 0.1% to 2% of Ca, 0.1% to 1% of Mn and the balance Mg and other inevitable impurities. The die-casting magnesium alloy manufacturing method comprises smelting, refinement and die-casting. The die-casting magnesium alloy has good mechanical performance, die-casting performance and heat conduction performance.

Abstract: A system for casting an aluminum alloy includes a first chamber for containing a first melt at a first temperature, a second chamber for containing second melt at a second temperature that is lower than the first temperature, a mixing chamber in communication with the first chamber and the second chamber for simultaneously receiving and mixing the first melt from the first chamber with the second melt from the second chamber, and a mold chamber in communication with the mixing chamber and for receiving the mixed melt.

Abstract: Disclosed herein is an alloy for a vehicle garnish, which is made by mixing Cu as a base with Mg and Si to have a composition of CuaMgbSic, wherein the alloy can have a color close to Au and the color of the alloy can be changed, and wherein the allow can also be made to have a low specific gravity and at a low cost.

Abstract: A method of manufacturing a nickel-based superalloy component includes providing or obtaining, in a powdered form, a build material alloy including, on a weight basis of the overall build material alloy: about 9.5% to about 10.5% tungsten, about 9.0% to about 11.0% cobalt, about 8.0% to about 8.8% chromium, about 5.3% to about 5.7% aluminum, about 2.8% to about 3.3% tantalum, about 0.3% to about 1.6% hafnium, about 0.5% to about 0.8% molybdenum, about 0.005% to about 0.04% carbon, and a majority of nickel. The method further includes subjecting the build material alloy to a high energy density beam in an additive manufacturing process to selectively fuse portions of the build material to form a built component and subjecting the built component to a finishing process to precipitate a gamma-prime phase of the nickel-based superalloy.

Abstract: A nickel-based superalloy component includes a nickel-based superalloy metal. The nickel-based superalloy metal includes, on a weight basis of the overall superalloy metal: about 9.5% to about 10.5% tungsten, about 9.0% to about 11.0% cobalt, about 8.0% to about 8.8% chromium, about 5.3% to about 5.7% aluminum, about 2.8% to about 3.3% tantalum, about 0.3% to about 1.6% hafnium, about 0.5% to about 0.8% molybdenum, about 0.005% to about 0.04% carbon, and a majority of nickel. In some examples, the component includes a gas turbine engine component, such as a turbine blade or a turbine vane, and the metal form of the nickel-based superalloy may be used as a filler metal for welding a casting alloy, a wrought alloy, or a powder metal alloy or other wrought forms.

Abstract: An aluminum alloy having excellent formability and elasticity includes Ti, B, Mg, and the Al, wherein a composition ratio of Ti:B:Mg is 1:3.5˜4.5:1, and AlB2 and TiB2 are present as reinforcing phases.

Abstract: The invention relates to a thin sheet metal for a reinforcing or structural part of a car body, consisting of an aluminium alloy of the following composition, in weight per cent: Si: 10-14; Mg: 0.05-0.8; Cu: 0-0.2; Fe: 0-0.5; Mn: 0-0.5; optionally at least one element selected from Na, Ca, Sr, Ba, Yt and Li, the quantity of said element if selected being between 0.01 and 0.05 for Na, Ca, Sr, Ba and Yt and between 0.1 and 0.3 for Li; Sb: 0-0.05; Cr: 0-0.1; Ti: 0-0.2; other elements amounting to <0.05 each and a total of <0.15; and the remainder being aluminium. The invention also relates to the method for producing such a sheet metal and to the use of such a sheet metal for producing a reinforcing or strucural part for a car body. The sheet metals according to the invention advantageously have a modulus of elasticity of at least 77 GPa.

Abstract: An aluminum alloy material as one aspect of the present disclosure has a chemical composition including: Zn: more than 6.5% (mass %, same applies hereafter) and 8.5% or less; Mg: 0.5% or more and 1.5% or less; Cu: 0.10% or less; Fe: 0.30% or less; Si: 0.30% or less; Mn: less than 0.05%; Cr: less than 0.05%; Zr: 0.05% or more and 0.10% or less; and Ti: 0.001% or more and 0.05% or less, a balance including Al and inevitable impurities. In the aluminum alloy material, a mass ratio of Zn to Mg (Zn/Mg) is 5 or more and 16 or less, and a metallographic structure includes an equigranular recrystallized structure.

Abstract: A high-strength air-hardenable multiphase steel having minimal tensile strengths in a non air hardened state of 750 MPa and excellent processing properties, said steel comprising the following elements in % by weight: C?0.075 to ?0.115; Si?0.200 to ?0.300; Mn?1.700 to ?2.300; Cr?0.280 to ?0.4800; Al?0.020 to ?0.060; N?0.0020 to ?0.0120; S?0.0050; Nb?0.005 to ?0.050; Ti?0.005 to ?0.050; B?0.0005 to ?0.0060; Ca?0.0005 to ?0.0060; Cu?0.050; Ni?0.050; remainder iron, including usual steel accompanying smelting related impurities, wherein for a widest possible process window during continuous annealing of hot rolled or cold rolled strips made from the steel a sum content of M+Si+Cr in the steel is a function of a thickness of the steel strips according to the following relationship: for strip thicknesses of up to 1.00 mm the sum content of M+Si+Cr is ?2.350 and ?2.500%, for strip thicknesses of over 1.00 to 2.00 mm the sum of Mn+Si+Cr is ?2.500 and ?2.950%, and for strip thicknesses of over 2.

Abstract: The rolled rod for cold-forged thermally refined articles according to the present invention has a chemical composition consisting, in mass %: C: 0.22 to 0.40%, Si: 0.35 to 1.5%, Mn: 0.20 to 0.40%, P: less than 0.020%, S: less than 0.015%, Cr: 0.70 to 1.45%, Al: 0.005 to 0.060%, Ti: 0.01 to 0.05%, B: 0.0003 to 0.0040%, N: 0.0020 to 0.0080%, and O: 0.0020% or less, with the balance being Fe and impurities, and that satisfies Formula (1) and Formula (2), wherein a total area fraction of pro-eutectoid ferrite and pearlite is 90% or more, an area fraction of the pro-eutectoid ferrite is 30% or more, and the rolled rod has a tensile strength of 700 MPa or less. 0.50?C+Si/10+Mn/5+5Cr/22?0.85??(1) Si/Mn>1.

Abstract: A method for treating a material comprising: applying energy to a predetermined portion of the material in a controlled manner such that the local chemistry of the predetermined portion is altered to provide a predetermined result. When the material is a shape memory material, the predetermined result may be to provide an additional memory to the predetermined portion or to alter the pseudo-elastic properties of the shape memory material. In other examples, which are not necessarily restricted to shape memory materials, the process may be used to adjust the concentration of components at the surface to allow the formation of an oxide layer at the surface of the material to provide corrosion resistance; to remove contaminants from the material; to adjust surface texture; or to generate at least one additional phase particle in the material to provide a nucleation site for grain growth, which in turn, can strengthen the material.

Abstract: Provided herein are aluminum alloys having a uniform surface recrystallization texture. The uniform surface recrystallization texture can be provided by methods described herein. Also provided herein are methods to produce aluminum alloys having a uniform surface recrystallization texture, which may include homogenizing and hot rolling an aluminum cast product to a final gauge at a temperature greater than or about a recrystallization temperature.

Abstract: The stress corrosion cracking resistance of an aluminum alloy member consisting of 7000-series aluminum alloy extruded shape is improved. At least one region of a quenched aluminum alloy extruded shape is subjected to a restoring treatment of heating at a temperature-raising rate of 0.4° C./second or more, holding at a temperature ranging 300 to 590° C. for a time longer than zero second and cooling at a cooling rate of 0.5° C./second or more. A plastic working is applied to the region within 72 hours. The region is subjected to a heat treatment of heating at a temperature-raising rate of 0.4° C./second or more, holding at a temperature ranging 300 to 590° C. for a time longer than zero second and not longer than 300 seconds and cooling at a cooling rate of 2000° C./minute or less. The whole of the aluminum alloy extruded shape is subjected to an artificial aging treatment.

Abstract: Provided herein are variably flexible (i.e., variably stiff) metal alloys and methods of making the variably flexible (i.e., variably stiff) metal alloys. A variably flexible (i.e., variably stiff) metal alloy is a metal alloy that has areas of differing flexibility (i.e., stiffness, rigidity or elasticity) along a length of the metal alloy when the metal alloy is subjected to a load in use. Also provided herein are methods of making variably flexible (i.e., variably stiff) metal alloys and products including casting a metal alloy and selectively heat treating portions of the metal alloy to achieve predetermined stiffnesses in those portions.

Abstract: In the plasma spraying according to the present embodiment, the zircon powders are excessively heated to raise the average temperature of the molten particles to a temperature range of 2820 to 4200° C. As a result, SiO2 in the zircon powders is vaporized, and the component ratio of ZrO2 in the molten particles is relatively increased. Such zircon powders land on the surface of the base material, and the deposit coagulates, the coagulum forms a thermal sprayed coating with a high composition ratio Zr/Si.

Abstract: A steel according to an aspect of the present invention has a chemical composition within a predetermined range, in which a hardenability index Ceq ranges from greater than 7.5 to smaller than 44.0, an AlN precipitation index IAlN ranges from greater than 0.00030 to smaller than 0.00110, a metallographic structure includes ferrite ranging from 85 to 100 area %, an average distance between sulfides, which are observed in a cross section parallel to a rolling direction of the steel and have an equivalent circle diameter ranging from 1 ?m or greater to smaller than 2 ?m, is shorter than 30.0 ?m, and a presence density of the sulfides, which are observed in the cross section parallel to the rolling direction of the steel and have an equivalent circle diameter ranging from 1 ?m or greater to smaller than 2 ?m, is 300 pieces/mm2 or more.

Abstract: The invention relates to a method for the production of materials. In particular the invention relates to nanostructured materials, and an apparatus and method for the production thereof. In accordance with the invention nanostructured materials are produced by the subsequent steps of producing nanoparticles; transporting the nanoparticles into, and optionally through, a porous carrier by a gas flow; and depositing the nanoparticles onto the surface of said porous carrier in an essentially isotropic manner.

Abstract: In one aspect, coatings are described herein employing composite architectures providing high aluminum content and high hardness for various cutting applications. For example, a coated cutting tool comprises a substrate and a coating comprising a refractory layer deposited by physical vapor deposition adhered to the substrate, the refractory layer comprising a plurality of sublayer groups, a sublayer group comprising a titanium aluminum nitride sublayer and an adjacent composite sublayer comprising alternating nanolayers of titanium silicon nitride and titanium aluminum nitride.

Abstract: A method to transfer a layer of harder thin film substrate onto a softer, flexible substrate. In particular, the present invention provides a method to deposit a layer of sapphire thin film on to a softer and flexible substrate e.g. PET, polymers, plastics, paper and fabrics. This combination provides the hardness of sapphire thin film to softer flexible substrates.

Abstract: The present invention provides a micro evaporator, an oscillator integrated micro evaporator structure and a frequency correction method thereof. The micro evaporator comprises a micro evaporation platform, anchor points, supporting beams and metal electrodes, wherein one surface of the micro evaporation platform is an evaporation surface; the anchor points are located on two sides of the micro evaporation platform and have a certain distance to the micro evaporation platform; the supporting beams are located between the micro evaporation platform and the anchor points, one end of each supporting beam is connected with the micro evaporation platform and the other end is connected with the anchor point; the size of each supporting beam satisfies the following relation: T=P(L/2kbh)+Ta; and the metal electrodes are located on first surfaces of the anchor points.

Abstract: Provided is a high frequency inducted evaporation source device, comprising an inner crucible for carrying an evaporation material, an induction coil set on periphery of the inner crucible and a radio frequency generator connected with the induction coil and a radio frequency induction heating component located in the inner crucible; the induction coil used for receiving an alternating current of the radio frequency generator to generate an induced magnetic field; the radio frequency induction heating component comprising an induction inner core body of generating an induction current in an induced magnetic field of the induction coil and generating heat to heat the evaporation material. The present invention can effectively disperse the heating zone of the evaporation material to effectively avoid the issues that the local heating rate of evaporation material is not uniform, and the evaporation material near the inner crucible wall is locally overheated and cracked.

Abstract: A tungsten sintered compact sputtering target and film are provided. The purity of the tungsten is 5N (99.999%) or more and the content of impurity carbon in the tungsten is 5 wtppm or less. The tungsten film, which is sputter-deposited by using the tungsten sintered compact sputtering target, has a low specific resistance due to the reduced carbon content in the tungsten target.