Abstract: Disclosed herein is a wearable drug delivery device including a container filled at least partially with a drug including at least one of a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody. The wearable drug delivery device may include a needle and an insertion mechanism configured to insert the needle into a patient. A fluid pathway connector may define a sterile fluid flowpath between the container and the insertion mechanism. Optionally, a cannula initially disposed about the needle may be included. The cannula may be retained in the patient at an injection site created by the needle after the needle is withdrawn from the patient. Methods of assembly and operation are also provided.

Abstract: A syringe includes a plunger and a spring embedded in a viscoelastic material. Expansion of the spring and the viscoelastic material applies a force on the plunger to move the plunger distally in the syringe.

Abstract: An insulin infusion set (30) for use with an inserter (40) is disclosed. The infusion set (30) includes an extension set (50). The extension set (50) includes a housing (70), a base (90) and a latching device (82). The base (90) houses a base septum (120) and an infusion cannula (42). The latching device (82) releasably attaches the housing (70) to the base. When the housing (70) is attached to the base (90), a part of the housing (70) extends into and opens the base septum (120).

Abstract: A needle assembly to prevent fluid/vapor escape so as to reduce or prevent fluid exposure to a clinician during use of the needle assembly. The needle assembly may include a handle portion with a needle extending therefrom, and a base portion releasably coupled to the handle portion. The base portion may include a safety assembly to shield a distal tip of the needle and prevent user contact therewith. The base portion may further include a self-sealing pad covering a bottom external surface thereof. The self-sealing pad may include an upper surface designed to mate with the base portion and a raised portion compressively positioned in the opening of the bottom external surface. The needle assembly may further include a fluid isolation component.

Abstract: An intracoronary catheter measures pressure distal to a lesion (Pd) and has a fluid lumen for administers adenosine to a patient's vasculature. A controller is configured to provide an injection of adenosine, wait for a period of time, measure Pd, and compare Pd to the Pd measured before the injection of the adenosine. If the difference between the pressures is small or below a threshold, the controller will stop further injections of adenosine because Pd has been determined to be at a relatively constant value. If the pressure difference is large or above a threshold, the controller will provide another adenosine injection, wait for a time period and again measure Pd and compare it to the previous Pd. This process will continue until the measured Pd reaches a relatively constant value.

Abstract: Provided is a flow rate control device for supplying liquid chemicals. The device according to an embodiment of the present disclosure includes a housing unit which is placed at the location from which liquid chemicals are supplied and comprises an inflow conduit on one side to which the liquid chemicals flow in and an outflow conduit from which the flowed-in liquid chemicals whose flow rate is controlled flow out; and a control unit which is integrated with the housing unit and comprises an inflow space which comes in contact with an inflow hole at a terminal portion of the inflow conduit, an outflow space which comes in contact with an outflow hole at a terminal portion of the outflow conduit and a control path which is connected between the inflow space and the outflow space to control the flow rate of the flowed-in liquid chemicals, wherein the control path has a controlled inner diameter and a controlled length according to the flow rate a user aims at.

Abstract: An automatic injection device with flow regulation. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the patient via an insertion device, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism. The potential energy source may be a spring that surrounds the drug container and may be magnetically coupled to the plunger. The clock escapement mechanism is configured to control the spring at a regulated rate over a time interval using a gearbox and rotational-to-linear translator comprising a rack and pinion.

Abstract: An automatic injection device with flow regulation. The automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the patient via an insertion device, a potential energy source, and a regulator configured to restrict release of potential energy and restrict linear movement of the plunger and pharmaceutical product into the fluid path at a proscribed pace. The regulator includes a clock escapement mechanism and a wire and pulley system including a wire coupled to at least one pulley. The potential energy source may be a spring that surrounds the drug container and may be directly coupled to the plunger and the wire such that movement of the spring and the wire is restricted over time.

Abstract: A handheld display device for processing continuous sensor data has a communication interface, a graphical user interface having a gesture recognition component, a processor and a memory. The processor continuously receives time dependent sensor data, carbohydrate data, event data, and insulin data. The event data is indicative of a physical state of the subject. The processor determines a sensor data scaling factor, a carbohydrate data scaling factor and an insulin data scaling factor. The processor controls the graphical user interface to render a plot having single time, analyte concentration, carbohydrate amount, and insulin delivery amount axes. The analyte concentration axis is rendered on a first side of the plot and carbohydrate amount and insulin delivery amount axes are rendered on an opposite side of the plot, according to the scaling factors. The graphical user interface can be controlled with single and/or double finger gestures to magnify, shrink or shift axes.

Abstract: An applicator has at least one barrel and a piston moveable within the at least one barrel between a variable first position and a second position. Movement of the piston towards the first position can draw a first fluid into the barrel, and movement of the piston towards the second position can force the first fluid out of the barrel. A fluid inlet valve allows the fluid to flow into the barrel at least under action of the piston, and a fluid outlet valve allows the fluid to flow out of the barrel. The piston is biased toward the first position and a dosage control part. An actuator is operable to move the piston to dispense the first fluid from the applicator.

Abstract: The present invention provides a drug delivery device (2, 3; 102) for sequential administration of substances, comprising a first variable volume reservoir (40a; 140a) holding a first substance and comprising a first outlet (41 a, 141 a) and a first displaceable wall (43a; 143a), a second variable volume reservoir (40b; 140b) holding a second substance and comprising a second outlet (41 b; 141 b) and a second displaceable wall (43b; 143b), a first wall actuation structure (65a, 70a, 75a, 77a; 177a) activatable to move the first displaceable wall (43a; 143a) and thereby expel a dose of the first substance through the first outlet (41 a; 141 a), a second wall actuation structure (65b, 70b, 75b, 77b; 177b) activatable to move the second displaceable wall (43b; 143b) and thereby expel a dose of the second substance through the second outlet (41 b; 141 b), and a drive structure (90; 190) for activating the first wall actuation structure (65a, 70a, 75a, 77a; 177a) and the second wall actuation structure (65b, 70b,

Abstract: An administration system for delivery of a pharmaceutical composition to a patient has a delivery device configured to deliver a dose of the pharmaceutical composition to the patient and a notification device in communication with the delivery device. The notification device is configured to communicate information about a status of at least one property of the delivery device. The delivery device is a wearable automatic injector configured to be worn on the patient's skin. A delivery device of the present disclosure allows a user or patient to view the status of a container. For example, a delivery device of the present disclosure provides a simple and effective visual means of displaying fill confirmation and delivery confirmation.

Abstract: A device has a hollow guide shell including an injection end and a longitudinal axis. An actuator magnet is disposed in the hollow guide shell. An injection pin is coupled to the actuator magnet. A driver magnet is positioned on the device radially outward from the actuator magnet. A fluid cartridge is disposed in the injection end of the hollow guide shell, the fluid cartridge including a needle and a plunger. The driver magnet selectively exerts an injection force on the actuator magnet in a direction oriented towards the injection end of the hollow guide shell to engage the injection pin with the fluid cartridge. A liquid, gas or other agent can selectively be ejected from the cartridge by the device to inject the fluid, gas or other agent into another object.

Abstract: In an embodiment, the present invention provides an autoinjector that has one or more slip-resistant features. In certain embodiments, the exterior surface of the autoinjector housing forms at least one of indentures and protrusions that impart a slip-resistant texture to the housing of the autoinjector. In other embodiments, the one or more slip-resistant features are included on a label, which comprises a label substrate and is attached to the exterior surface of the housing of the autoinjector. The features are designed to improve the handling properties of the autoinjector and reduce the likelihood that the autoinjector will slip out of a user's or caregiver's hand during use.

Abstract: The present disclosurerelates to a monitoring unit for a medicament delivery device, where the monitoring unit has a housing, monitoring circuit arranged in the housing, capable of detecting and monitoring functions of the medicament delivery device, releasable holding elements, which releasable holding elements interact with a medicament delivery device for releasably holding the monitoring unit when attached to a medicament delivery device. Locking elements are operably arranged in the monitoring unit to act on the attachment mechanism, and at least one drive element is operably connected to the locking elements wherein, upon activation of the monitoring unit, the at least one drive element causes the locking elements to act on the releasable holding elements, preventing detachment of said monitoring unit from the medicament delivery device.

Abstract: A syringe having a dispensing element (20) and having a mounting element (2), wherein the dispensing element (20) has a dispensing sleeve (21) and a leaf spring system (3), wherein the mounting element (2) has a syringe body (17), and an injection needle (16) is formed on one end on the syringe body (17) and a detent-engagement flange (19) is formed on the other end, wherein, in the syringe body (17), there is arranged a movable stopper (18), wherein the leaf spring system (3) comprises a piston (6) and a spiral spring (5) arranged around the piston (6), wherein the piston (6) can be slid into the dispensing sleeve (21), and the spiral spring (6) is arranged between a leaf spring base (22) and a spiral spring abutment, wherein the piston (6) abuts against the stopper (18), wherein the dispensing sleeve (21) has a guide duct and the dispensing sleeve (21) comprises a first locking means (7) and a second locking means (9), wherein the detent-engagement flange (19) is movable in the guide duct and is fixable and

Abstract: In one aspect the present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge filled with a liquid substance. In a further aspect the disclosure relates to a drug delivery device equipped with such a sensor, wherein the sensor includes a planar flexible foil having a first section and having a second section separated from the first section, at least one measurement electrode located on the flexible foil, wherein the flexible foil is wrappable into a wrapped configuration in which the foil forms at least a first wrap with an inner diameter that is equal to or larger than an outer diameter of the cartridge, wherein in the wrapped configuration the first section and the second section at least partially overlap, at least one fastener located in one of the first and second section and configured to attach to the other one of the first and second sections for keeping the flexible foil in the wrapped configuration.

Abstract: Disclosed herein is a pharmaceutical delivery device comprising a cartridge containing a fluid, the cartridge including a light pipe section which acts as a light pipe having an input location; and a light diffusing section optically coupled to the light pipe; and a light source optically coupled to the cartridge at the input location to the light pipe, such that at least some light from the light source entering at the input location is diffused at the light diffusing section.

Abstract: Described is a catheter patency maintenance device comprising of a flush syringe, an elongate plunger rod with a stopper slidably positioned within the barrel, a cap, disinfectant and a valve movable between an open position and a closed position. The valve may include a valve stem and/or openings in the valve to permit fluid flow. Methods of using the flush syringe assemblies are also described.

Abstract: A drug container includes a container body formed of a thermoplastic resin containing a cyclic polyolefin as a main component. The thermoplastic resin contains, as a lubricant, at least one compound selected from among a metal soap compound, an organic fatty acid ester compound, a synthetic wax compound, and a fatty acid amide compound. The lubricant content of the thermoplastic resin is 0.3 to 2.0 ?g/g.

Abstract: A seal member is for use with a syringe assembly that comprises a syringe comprising a cylinder body configured to be filled with a drug solution. The seal member includes: a tubular main body part including: an aperture part formed in a proximal end of the main body part, and a contact part configured to form a fluid-tight seal with an inner wall of the cylinder body; and a closed end part at a distal end of the main body part, the closed end part sealing the distal end of the main body part. The closed end part comprises a cleavable part connected to the aperture part, the cleavable part being configured to be cleaved to form a liquid transmission aperture connecting with the aperture part upon application of a prescribed pressure to the a drug solution within a drug solution storage space in the cylinder body.

Abstract: A drive mechanism for a delivery device comprising a rotator (60) comprising an outer surface and an inner surface, the rotator configured to rotate from a first position to a second position; and a needle cover (110) comprising an inner surface that engages the outer surface of the rotator. An end of injection indication device (130) is positioned at least partially within a plunger rod spring (150), the end of injection indication device providing a signal to a user of the drive mechanism that an injection has been completed.

Abstract: An apparatus includes a pen body of a drug injection pen including a dosage injection mechanism that produces a rotational motion when the drug injection pen dispenses a fluid. The apparatus also includes a button housing with at least part of a dosage measurement system disposed within the button housing. At least part of the dosage measurement system is coupled to receive the rotational motion from the dosage injection mechanism. The dosage measurement system includes one or more sensors positioned to output a signal in response to the rotational motion when the drug injection pen dispenses a fluid, and a controller coupled to the one or more sensors to receive the signal. A drug delivery control wheel of the drug injection pen is disposed between the body of the drug injection pen and the at least part of the dosage measurement system disposed in the button housing.

Abstract: The present invention relates to a medicament delivery device (10) comprising a housing (12, 14); a medicament container holder (90), arranged movable in relation to said housing (12, 14) and capable of accommodating a medicament container (92); an biased activator (160) comprising a plunger rod (164), which plunger rod (164) is arranged to act on the medicament container (92) for delivering a dose of medicament through a medicament delivery member (102 when said biased activator (160) is operated; a manually operable dose setting member (72) operably connected to both said housing and said medicament container holder such that manual operation of said dose setting member (72) will cause the medicament container holder (90) with the medicament container (92) to move towards said plunger rod (164) for setting a dose of medicament to be delivered; a dose drum (56) releasably connected to the dose setting member (72) through a releasable connection mechanism (68, 84I) such that when the dose setting member is op

Abstract: A drug injection pen includes a housing shaped to accept a cartridge containing a fluid, and a dosage injection mechanism positioned in the housing to produce a rotational motion and force the fluid out of the cartridge when the drug injection pen dispenses the fluid. A dosage measurement system is disposed in the drug injection pen and is coupled to measure a strain induced in a portion of the dosage measurement system. The dosage measurement system outputs a signal indicative of the strain, and the strain on the portion of the dosage measurement system changes when the dosage injection mechanism dispenses the fluid. The dosage measurement system outputs a signal indicative of the strain when the drug injection pen dispenses the fluid. A controller is coupled to the dosage measurement system, and the controller performs operations including recording the signal output from the dosage measurement system.

Abstract: Method of manufacturing a drug delivery device, comprising the steps of (i) providing a plurality of components which in an assembled state form a processor-controlled drug delivery device, (ii) determining a parameter value for at least one component, (iii) assembling the components to form a drug delivery device, and (iv) storing in the processor memory correction data, the correction data being based on one or more differences between a determined parameter value and a corresponding nominal value.

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: A needle apparatus having a sheath with a protective hypotube insert and a method of making the needle sheath. An example needle apparatus includes a handle, a needle having a proximal end connected to the handle and a sheath. The sheath is configured to receive of the needle. The sheath includes a proximal end connected to the handle, a distal end, a lumen and the protective insert. The lumen passes from the proximal end to the distal end of the sheath. The protective insert is received within the lumen at the distal end of the sheath when force and/or heat are applied.

Abstract: According to the invention, a safety device for a pre-filled syringe with an injection needle comprises of a support body adapted to mount the pre-filled syringe, a needle shield slidably arranged with respect to the support body, a retention and locking means (M) for retaining and locking the needle shield with respect to the support body in a first and a second advanced position (PA1, PA2) and in a retracted position (PR). The needle shield comprises an annular flange adapted to rest on the skin of the patient receiving an injection. The retention and locking means (M) are arranged at a distal end of the safety device.

Abstract: The present disclosure provides devices for implanting tissue or other substances within the body. The devices can include a feedback mechanism, which can assist a surgeon in implanting the tissue or other substances by preventing excess shear force or pressure on the tissue or substance to be implanted.

Abstract: The present invention relates to drug delivery systems that cannot be reloaded or reused and further include a passive safety shield system. The drug delivery devices described herein comprise a drug container comprising at least one bellow, wherein the at least one bellow comprises a first surface and an opposing second surface, wherein the first surface is comprised of a first Belleville spring and the opposing second surface is comprised of a second Belleville spring, wherein the second Belleville spring has a higher spring rate than the first Belleville spring; or a drug container extending between distal and proximal ends, and comprises a continuous change in cross section from proximal end to distal end; a needle, wherein the needle is in liquid communication with the drug container; a plunger extending between a proximal end and a distal end, wherein the plunger is in communication with the drug container and where upon axial movement of the punger, the drug container is compressed.

Abstract: A system is disclosed. The system includes a reservoir for containing a fluidic medium, the reservoir including a front surface, a resilient cylindrical flexure portion connected to the front surface, the resilient cylindrical flexure portion comprising an accordion-like structure that is able to expand and contract to change an interior volume within the resilient cylindrical flexure portion, a central passageway within the resilient cylindrical flexure, and a collection chamber connected to the central passageway. Also, a system including a reservoir, a plunger head located within the reservoir, a plunger arm connected to the plunger head, a driving shaft connected to the plunger arm, and a motor connected to the driving shaft, the motor controllable to move the drive shaft in a first motion and a second motion so as to move the advance plunger head and retract the plunger head within the reservoir.

Abstract: Provided herein is a device for ereptiospirating an inhalable material such as a medical wax or solid or highly viscous oil comprising a medication. More particularly, provided herein is a device for continuously ereptiospirating an inhalable material and for delivery of dosages of the inhalable material to patients via direct lung inhalation.

Abstract: An auto-reset dose release firing system (101) and a method of using same. The system can include an a stored energy device (109); a first plunger (103) movable between first, second, and third positions, the first plunger configured to be operatively coupled to a medicament canister (51); and a second plunger (104) movable between first and second positions; the first and second plunger being movable with respect to one another and shaped to define an evacuable chamber (185) therebetween. The first plunger and the second plunger can move together from their respective first positions to their respective second positions, due to a reduced pressure in the chamber, to cause a dose release valve (54) to fire. After firing, air can be allowed to move into the chamber to allow the first plunger to move with respect to the second plunger to its third position to allow the dose release valve to reset.

Abstract: A water pipe attachment, specifically, a quartz banger for placing therein a smoking substance, and a color changing surface inserted therein, not limited to any location around the neck and head area of the banger to change color initially in response to heat as high as 300 to 400 degrees.

Abstract: A control system provides automated control of gas washout of a patient interface, such as a mask or nasal prongs. A gas washout vent assembly of the system may include a variable exhaust area, such as one defined by gears, radial exhaust revolvers and/or flow diverters for a conduit having a variable gas passage channel. The vent assembly may be attached substantially near or included with the patient interface. An actuator of the assembly, such as a solenoid, motor or voice coil, manipulates the vent assembly. The actuator may be configured for control by a processor to change the exhaust area of the vent assembly based on various methodologies including, for example, sleep detection, disordered breathing event detection and/or leak detection.

Abstract: The invention relates to a ventilation device for ventilating a patient, comprising at least a fluid supply unit or, additionally, a fluid discharge unit which can be used to guide a fluid into at least one airway, that is part of a lung or in a lung, of a patient or for discharging the fluid from said airway; and to a control device which, during the ventilation of at least one airway of the patient, can be used to guide a fluid into the at least one airway and/or discharge the fluid from at least one airway by operating the ventilation device, for determining or also for estimating a path of at least one region of a compliance curve of the at least airway by guiding and/or discharging the fluid from the at least one airway and by determining at least one value of the compliance. The invention also relates to a method for operating a ventilation device.

Abstract: Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The positioning and stabilising structure may comprise at least one gas delivery tube to deliver the flow of air to the entrance of a patient's airways via the seal-forming structure. The at least one gas delivery tube may be constructed and arranged to contact, in use, at least a region of the patient's head superior to an otobasion superior of the patient's head. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of a length of the at least one gas delivery tube to enable the positioning and stabilising structure to fit different size heads.

Abstract: This invention relates to connectors to be provided into fluid communication or engagement either directly with, or via a component to be associated with, a terminal end of a breathing conduit. In at least one embodiment, the connector comprises a body having a first end and a second end, and an internal lumen for the passage of gas between the ends. The first end engageable with a terminal end of a conduit or a component to be associated therewith. The second end engageable with another connector. An internal surface of the body at the second end comprises internal connection features for connection with another connector to be received internally therein. An external surface of the body comprises one or more external alignment feature(s) for aligning the connector or another connection into an aligned orientation for connection therebetween.

Abstract: A vaporizer and vaporizer cartridge for inhaling vapors from vaporized oil. The vaporizer has a mouthpiece for use by a user to inhale the vapors. The mouthpiece is connected to a cartridge which contains the oil to be vaporized and the apparatus for vaporizing the oil. The vaporizer cartridge contains a reservoir of the oil which flows down to a wick, which is heated by a heating coil to a temperature necessary to vaporize the oil. Under the wick is a residue basin which collects any oil which fails to vaporize. The residue basin is placed at an optimal distance from the wick such that when the next user initiates another draw on the vaporizer, the un-vaporized oil in the residue basin is vaporized. Below the cartridge is a battery component that provides power to a heating coil which heats the wick to vaporize the oil. Air flows up from below the cartridge on one side, then cross-flows across the wick and residue basin, and up the other side of the cartridge to the mouthpiece.

Abstract: A relief valve in which a valve body is automatically properly opened/closed by pressure of gas while having a simple device structure, and a device including the relief valve. In a valve-closed state, a first pressure receiving surface portion receives pressure of gas from a valve hole to smoothly open a valve body, and in an open position after the valve is opened, a pressure receiving area is enlarged to a second pressure receiving surface portion, and the first pressure receiving surface portion and the second pressure receiving surface portion are surrounded by a peripheral wall portion formed on a back surface of the valve body. Thus, the valve body continuously receives the pressure with the pressure of the gas being reduced, thereby allowing the valve-opened state of the valve body to be stably maintained to set pressure.

Abstract: Systems and methods are provided for mitigating motion sickness. When motion sickness is predicted, the motion sickness mitigation system alters vehicle performance, cabin conditions, and/or alerts the occupant to upcoming vehicle actions, to avoid or alleviate motion sickness. A controller includes a processor that receives an occupant profile and traffic information for an upcoming trip of the vehicle on a route. Using the occupant profile and the traffic information, the processor calculates whether the occupant will experience motion sickness when the vehicle travels on the route. A vehicle performance signal correlated to the calculation, is delivered by the processor to initiate motion sickness mitigation. The vehicle performance signal varies operation of a steering actuator, an acceleration actuator, and/or a brake actuator to implement the motion sickness mitigation.

Abstract: An earphone includes a loudspeaker, a microphone, a housing supporting the loudspeaker and microphone, and ear tip surrounding the housing and configured to acoustically couple both the loudspeaker and the microphone to an ear canal of a user, and to acoustically close the entrance to the user's ear canal. A processor provides output audio signals to the loudspeaker, receives input audio signals from the microphone, extracts a rate of respiration from the input audio signals, adjusts the output audio signals based on the extracted rate of respiration, and provides the adjusted output audio signals to the loudspeaker.

Abstract: An earphone includes a loudspeaker, a microphone, a housing supporting the loudspeaker and microphone, and an ear tip surrounding the housing and configured to acoustically couple both the loudspeaker and the microphone to an ear canal of a user, and to acoustically close the entrance to the user's ear canal. A processor receives input audio signals from the microphone, detects peaks having a frequency of around 1 Hz in the input audio signals, based on the detected peaks, computes an instantaneous heart rate, measures a frequency of an oscillation within the instantaneous heart rate, and based on the frequency of the oscillation, computes a rate of respiration.

Abstract: A system for inducing sleep of an infant includes: a cushion main body, an operation main body unit provided inside the cushion main body, a measurement means connected to the operation main body unit to measure heartbeat of a human body, and a switch unit, wherein the measurement means includes a hollow case opened toward one side and a measurement unit provided in an opening of the case to measure the heartbeat; the operation main body unit includes a main body unit, a control unit provided in the main body unit, a storage unit connected to the control unit and provided in the main body unit, an output unit connected to the control unit and provided in the main body unit, and a display unit connected to the control unit and provided in the main body unit; and the switch unit is provided to be connected to the control unit.

Abstract: A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.

Abstract: A catheter including a tubular catheter body defining a distal portion, a distal end and a lumen that extends to the distal end, a radiopaque marker carried within the lumen, and a non-metal tip that is bonded to distal end of the catheter body.

Abstract: Embodiments of the present disclosure are directed to apparatuses, systems, and methods for merging an endoscopic basket delivery catheter onto a fixed guidewire. In one implementation, a catheter may include a sheath having a saddle secured to a distal portion thereof. The sheath may constrain an endoscopic tool such as a basket therein, while the saddle may receive a portion of a guidewire. The saddle may include a slit extending along its longitudinal length. The slit may be widened by a working member of an adapter to allow passage of a locked guidewire into the guidewire lumen of the saddle. The catheter may be merged onto the guidewire via the slit and delivered to the desired treatment device without unlocking of the guidewire. Advantageously, access to at least one desired treatment site may be maintained with the guidewire during merging of the catheter.

Abstract: Embodiments of the present disclosure are directed to cannulating devices and methods for exchanging cannulating devices in an endoscopic procedure. In one implementation, an apparatus for endoscopic operations is described. The apparatus includes a cannulating device to be introduced through an internal lumen of an endoscope via a biopsy port. The cannulating device has an elongated body. The elongated body includes a guidewire lumen configured to receive a guidewire therein, and a slit extending over at least a portion of the length of the elongated body from a distal tip to a proximal position of the elongated body.

Abstract: A catheter insertion device which employs back-and-forth longitudinal axial movement to advance the catheter by the cooperative interface of an incline ramp and a decline ramp with a split gripping mechanism is described.