Patents Issued in January 24, 2019
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Publication number: 20190023606Abstract: Intermediate to high CTE glass compositions and laminates formed from the same are described. The glasses described herein have properties, such as liquidus viscosity or liquidus temperature, which make them particularly well suited for use in fusion forming processes, such as the fusion down draw process and/or the fusion lamination process. Further, the glass composition may be used in a laminated glass article, such as a laminated glass article formed by a fusion laminate process, to provide strengthened laminates via clad compression as a result of CTE mismatch between the core glass and clad glass.Type: ApplicationFiled: September 26, 2018Publication date: January 24, 2019Inventors: Timothy James Kiczenski, John Christopher Mauro, Michelle Diane Pierson-Stull, Robert Anthony Schaut, Natesan Venkateraman
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Publication number: 20190023607Abstract: It is related to a metal/polymer nanocomposite film comprising gold nanoparticle which has gold mirror feature, comprises acrylic based oligomer, acrylic based monomer, 2-mercapto thioxanthone which is an one-component type II. radicalic photoinitiator and chloroauric acid.Type: ApplicationFiled: December 28, 2016Publication date: January 24, 2019Inventors: Nergis ARSU, Tolga CEPER
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Publication number: 20190023608Abstract: A vehicle glazing includes on its surface to be exposed to the exterior atmosphere, at least in a zone not wiped by the windscreen wipers, a mineral oxide layer of 0.1 to 20 ?m thickness, 30 to 90% of the volume of which consists of 20 to 300 nm open pores that are distributed uniformly throughout the thickness of the layer, and almost all of which are connected to one another, the internal and external surface of the layer being functionalized with a compound containing a perfluoroalkyl or alkyl functional group, then saturated with a hydrophobic oil that impregnates the functionalized porous layer and forms a film on the surface thereof, the at least one zone being located facing a detecting device such as an anti-collision/obstacle-detecting/security video camera, or similar, placed in the interior of the vehicle, in particular on the face of the glazing.Type: ApplicationFiled: September 6, 2016Publication date: January 24, 2019Inventors: Barbara BRUDIEU, François GUILLEMOT, Jérémie TEISSEIRE
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Publication number: 20190023609Abstract: An optical component according to an embodiment of the present invention includes a translucent substrate, one or more intermediate layers stacked on at least one of an incident surface and an exit surface of the substrate, and a surface layer stacked on an outermost layer of the one or more intermediate layers, the surface layer containing diamond-like carbon as a main component. At least one intermediate layer among the one or more intermediate layers contains silicon as a main component, and the intermediate layer containing silicon as a main component has an oxygen content of 10 atomic % or less.Type: ApplicationFiled: January 12, 2017Publication date: January 24, 2019Inventors: Ryota YAMAGUCHI, Soichiro OKUBO
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Publication number: 20190023610Abstract: A transparent pane comprising a transparent substrate and an electrically conductive coating on a surface of the transparent substrate is disclosed. The electrically conductive coating comprises four functional layers arranged one atop another. Each functional layer comprises a layer of optically highly refractive material with a refractive index >1.3, a first matching layer above the layer of optically highly refractive material, an electrically conductive layer above the first matching layer, and a second matching layer above the electrically conductive layer. The layer thickness of each conductive layer can be 5 nm to 25 nm and the total layer thickness of all electrically conductive layers can be 20 nm to 100 nm.Type: ApplicationFiled: March 20, 2017Publication date: January 24, 2019Inventors: Klaus FISCHER, Matthias KUEHNE, Sandra HORNSCHUH, Roberto ZIMMERMANN, Martin HENSELER, Dagmar SCHAEFER, Michael JANSEN
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Publication number: 20190023611Abstract: Asymmetrically strengthened glass articles, methods for producing the same, and use of the articles in portable electronic device is disclosed. The asymmetrically strengthened glass articles include glass articles having a deeper compressive stress layer in a thicker portion of the glass article. Using a budgeted amount of compressive stress and tensile stress, asymmetric chemical strengthening is optimized for the utility of a glass article. In some aspects, the strengthened glass article can be designed for reduced damage, or damage propagation, when dropped.Type: ApplicationFiled: September 26, 2018Publication date: January 24, 2019Inventors: Victor Luzzato, Christopher D. Prest, Dale N. Memering, Matthew S. Rogers
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Publication number: 20190023612Abstract: Disclosed are product (e.g., board), slurry, and methods relating to an uncooked starch that can be used to enhance strength in one or more gypsum layers in the board. The uncooked starch has a hot water viscosity of from about 20 BU to about 300 BU according to the HWVA method, and/or a mid-range peak viscosity of from about 120 Brabender Units to about 1000 Brabender Units.Type: ApplicationFiled: July 3, 2018Publication date: January 24, 2019Applicant: United States Gypsum CompanyInventors: Yijun SANG, Brian J. CHRIST
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Publication number: 20190023613Abstract: Disclosed is a reaction resin composition comprising: a radically polymerizable compound; an initiator system having an a-halo carboxylic acid ester and a catalyst system containing a copper (II) salt, a reducing agent and at least one ligand containing nitrogen; a hydraulically curing compound; and water. Also disclosed is a two- or multi-component system containing said reaction resin composition and uses of said composition for construction applications.Type: ApplicationFiled: December 15, 2016Publication date: January 24, 2019Inventors: Angel JIMENEZ, Mickael GALLEF, Armin PFEIL
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Publication number: 20190023614Abstract: Disclosed are product (e.g., panels), slurry, and methods relating to an uncooked starch having a mid-range peak viscosity (i.e., from about 120 Brabender Units to about 900 Brabender Units).Type: ApplicationFiled: March 23, 2018Publication date: January 24, 2019Inventors: Yijun SANG, Brian J. CHRIST
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Publication number: 20190023615Abstract: Compositions for the treatment of flue gas desulfurization scrubber effluent may generally comprise, based on weight percent of the composition, at least 50% fly ash, up to 20% calcium oxide and/or calcium hydroxide, up to 2% plasticizer and a balance of incidental impurities. Methods for the treatment of flue gas desulfurization scrubber effluent using the composition for the treatment of flue gas desulfurization scrubber effluent are also described.Type: ApplicationFiled: July 24, 2018Publication date: January 24, 2019Applicant: Carmeuse North AmericaInventors: Dale C. Andrews, Lance Olson
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Publication number: 20190023616Abstract: A polycrystalline dielectric thin film and capacitor element has a small dielectric loss tan ?. The polycrystalline dielectric thin film, in which the main composition is a perovskite oxynitride. The perovskite oxynitride is expressed by the compositional formula AaBbOoNn (a+b+o+n=5), where a/b>1 and n?0.7.Type: ApplicationFiled: February 1, 2017Publication date: January 24, 2019Applicant: TDK CORPORATIONInventors: Kumiko YAMAZAKI, Hiroshi CHIHARA, Yuki NAGAMINE, Junichi YAMAZAKI
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Publication number: 20190023617Abstract: A ceramic matrix composite article includes a melt infiltration ceramic matrix composite substrate comprising a ceramic fiber reinforcement material in a ceramic matrix material having a free silicon proportion, and a chemical vapor infiltration ceramic matrix composite outer layer comprising a ceramic fiber reinforcement material in a ceramic matrix material having essentially no free silicon proportion disposed on an outer surface of at least a portion of the substrate.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Inventors: Krishan Lal Luthra, Gregory Scot Corman, Badri Narayan Ramamurthi
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Publication number: 20190023618Abstract: A method for making a composite material includes disposing a quantity of liquid comprising at least 90 weight percent molten boron within pores of a porous preform, the preform comprising a preform material; and reacting at least a portion of the molten boron with a portion of the preform material to form a solid ceramic reaction product, thereby forming a ceramic matrix composite material. An article comprises a composite material; the composite material comprises a fibrous phase disposed within a matrix. The matrix comprises silicon carbide, boron carbide, and boron silicide.Type: ApplicationFiled: September 25, 2018Publication date: January 24, 2019Inventor: Gregory Scot Corman
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Publication number: 20190023619Abstract: The present invention relates to a copper-ceramic composite comprising—a ceramic substrate which contains aluminum oxide, the aluminum oxide having particle sizes in the range of 0.01 ?m to 25 ?m and a quantity distribution of the particle sizes with a median value d50 and an arithmetic mean value darith, and the ratio of d50 to darith being in the range of 0.75 to 1.10, —a coating made of copper or a copper alloy provided on the ceramic substrate.Type: ApplicationFiled: February 16, 2017Publication date: January 24, 2019Inventors: KAI Herbst, Christian Muschelknautz
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Publication number: 20190023620Abstract: A blended composition for use as an admixture for cementitious materials, compressing polystyrene dissolved in a cyclic terpene, and capable of modifying the strength, plasticity, and water-permeability of the cement.Type: ApplicationFiled: July 23, 2018Publication date: January 24, 2019Inventors: Darrin Vogeli, Molly Wells Vogeli
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Publication number: 20190023621Abstract: Some examples include a turbine component comprising: a ceramic composite (CMC) having a matrix; and a watertight coating chemically miscible and/or mutually soluble with/in the CMC because particles and/or fibers which are composed of an identical or chemically matching, but at least chemically compatible. At least part of the watertight coating is incorporated in the matrix of the CMC, the matching and compatible material comprising at least one of: aluminum oxide, yttrium aluminum garnet (YAG), and yttrium-stabilized zirconium oxide (YSZ).Type: ApplicationFiled: January 11, 2017Publication date: January 24, 2019Applicant: Siemens AktiengesellschaftInventors: Gia Khanh Pham, Niels Van der Laag
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Publication number: 20190023622Abstract: The invention herein provides a composite material suitable for the absorption of moisture in natural outside areas. More particularly, the composite material can be applied to both grassy and non-grassy natural areas to both absorb any excessive, apparent moisture therein and to also enrich the underlying earth of both grassy and non-grassy natural areas.Type: ApplicationFiled: July 21, 2017Publication date: January 24, 2019Inventor: DERRICK ROBERT MAYES
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Publication number: 20190023623Abstract: A composition, in the form of an aqueous suspension. The composition comprises at least one form of attapulgite present in a solid weight fraction (SWF) amount ranging from 0.065% to 0.30%. The composition comprises kaolin present in a percent solids by weight (w/w %) amount ranging from 0.80% to 2.80%. The composition comprises one or more main plant nutrients or major animal mineral nutrient supplements. In the composition, the total percent solids by weight (w/w %) amount in the composition ranges from 45% to 90%. Although usable for other purposes, the composition is usable as a fertilizer. Although makeable in other ways, the composition is makeable by mixing the ingredients with agitation sufficient enough to form an aqueous suspension.Type: ApplicationFiled: August 4, 2016Publication date: January 24, 2019Inventors: Steven B. FELDMAN, Jeffery CARR, JR., Matthew J. LYMAN, John KITCHENS, Luke FUHRMANN, Robert J. PURCELL, JR., Dennis . PARKER
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Publication number: 20190023624Abstract: The present application relates to systems and methods for processing organic material. The methods may include extraction of biochemical nutrients from organic material, such as food scraps. The method can include comminuting the organic material to form a slurry from components comprising liquid and organic material; combining the slurry with microorganisms, such as a yeast, under aerobic conditions to form a mixture of the slurry and yeast; aerating the mixture; and forming a biomass and a nutrient-rich broth, in which the biochemical nutrients are stabilized and anabolized. The systems may, in some embodiments, be configured to perform the methods of processing organic materials.Type: ApplicationFiled: July 31, 2018Publication date: January 24, 2019Applicant: WISErg CorporationInventors: Larry LeSueur, Jose Lugo, Ken Deering, Victor V. Tryon, Michael Bridges, Lee Wilkerson, Trevor Lewis
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Publication number: 20190023625Abstract: The present invention provides a vertical gas distribution device for aerobic compost and a gas distribution method. Current gas distribution pipelines are easily blocked by organic materials, resulting in poor ventilation due to non-uniform local ventilation and cleaning difficulties. The inventive device comprises a compost chamber, a compost bin, a compost heap, a percolate tank, and a plurality of gas distribution branch pipes at the bottom of the compost chamber, the pipes being vertically movable in the chamber; the percolate tank is positioned at the bottom of the chamber and under the pipes; an air inlet is provided on the side wall of the tank, and an outlet is provided on the side wall of the chamber; the compost bin is inside the compost chamber, and the compost heap is in the compost bin; each pipe is top sealed, with a plurality of vent holes on the side wall, and its bottom connected to the tank. The present invention is usable for compost ventilation.Type: ApplicationFiled: June 6, 2018Publication date: January 24, 2019Inventors: Zimin Wei, Beidou Xi, Baiyan Cai, Xu Zhang, Dan Wei, Liming Jia, Xinyu Zhao, Mingxiao Li, Tianxue Yang, Yue Zhao
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Publication number: 20190023626Abstract: Provided is a coated granular fertilizer, which includes a granular fertilizer and a resin coat that coats the granular fertilizer, in which the resin coat contains a urethane resin that is a polyaddition product between a polyisocyanate component and a polyol component, the polyisocyanate component includes an aromatic polyisocyanate, and the polyol component includes a castor oil-modified diol, an alkylene diol having 2 to 8 carbon atoms, and a compound having three or more hydroxyl groups.Type: ApplicationFiled: September 1, 2016Publication date: January 24, 2019Applicant: Sumitomo Chemical Company, LimitedInventor: Mitsuhiro SASAKAWA
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Publication number: 20190023627Abstract: Aspects of the invention include compositions for controlling plant parasitic nematodes. Compositions according to certain embodiments include a carbon skeleton energy compound, a chelating agent, macronutrients, micronutrients, an ionophore, exotic micronutrients and a plant parasitic nematode antagonist. Methods for using the compositions of the invention to control plant parasitic nematodes and kits having one or more compositions for controlling plant parasitic nematodes are also described.Type: ApplicationFiled: September 20, 2018Publication date: January 24, 2019Inventor: Thomas T. Yamashita
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Publication number: 20190023628Abstract: The invention relates to a cast explosive composition comprising a polymer-bonded explosive and a defoaming agent, and to a process for reducing the number and/or total volume of voids in a cast explosive composition comprising the steps of: combining a polymer-bonded explosive and a defoaming agent; and casting the explosive composition. The defoaming agent may be used for reducing the number and/or total volume of voids in a cast explosive composition and the cast explosive composition may be used in an explosive product.Type: ApplicationFiled: November 29, 2017Publication date: January 24, 2019Applicant: BAE SYSTEMS plcInventors: Ronald Edward HOLLANDS, Ian Ewart Paterson MURRAY
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Publication number: 20190023629Abstract: A priming mix composition includes between about 30% and about 60% of at least one of KDNBF, dinol, and tetrazene as a primary explosive; between about 10% and about 35% of a metallocene as a propagation aid; between about 5% and about 40% of at least one nitrate, peroxide, or oxide, as an oxidizer; between about 5% and about 25% of at least one of nitrocellulose or PETN as a reactive fuel; and a fuel. The metallocene is preferable ferrocene.Type: ApplicationFiled: September 22, 2017Publication date: January 24, 2019Inventors: Toni M. Whaley, Morris C. Buenemann, JR., George C. Mei
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Publication number: 20190023630Abstract: A high strength engineered reactive matrix composite that includes a core material and a reactive binder matrix combined in high volumes and with controlled spacing and distribution to produce both high strength and controlled reactivity. The engineered reactive matrix composite includes a repeating metal, ceramic, or composite particle core material and a reactive binder/matrix, and wherein the reactive/matrix binder is distributed relatively homogeneously around the core particles, and wherein the reactivity of the reactive binder/matrix is engineered by controlling the relative chemistry and interfacial surface area of the reactive components. These reactive materials are useful for oil and gas completions and well stimulation processes, enhanced oil and gas recovery operations, as well as in defensive and mining applications requiring high energy density and good mechanical properties.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Inventors: Andrew J. Sherman, Brian P. Doud
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Publication number: 20190023631Abstract: The present invention provides improved processes for preparing halogenated alkanes. In particular, the processes comprise reacting an alkene, a halogenated alkene, or combinations thereof and a halogenated methane with at least one chlorine atom.Type: ApplicationFiled: January 4, 2017Publication date: January 24, 2019Inventors: John D. Myers, Max M. Tirtowidjojo, Thomas U. Luebbe, Marc M. Sell
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Publication number: 20190023632Abstract: A process is described for producing 1,3-butanediol, wherein an ester of poly-(R)-3-hydroxybutyrate such as formed by transesterification with an alcohol is reduced by hydrogenation in the presence of a skeletal copper-based catalyst to provide 1,3-butanediol. The 1,3-butanediol may be transesterified by reaction with additional poly-(R)-3-hydroxybutyrate ester to produce (R)-3-hydroxybutyl (R)-3-hydroxybutyrate.Type: ApplicationFiled: December 8, 2016Publication date: January 24, 2019Inventors: Paul Bloom, Chi Cheng Ma, Kevin Martin, Brennan Smith
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Publication number: 20190023633Abstract: The invention relates to a process for preparing substituted 2-arylethanols of the formula (I) by reacting Grignard compounds of the formula (II) in the presence of a copper compound with ethylene oxide. Moreover, the invention relates to novel substituted 2-arylethanols of the formula (I).Type: ApplicationFiled: January 9, 2017Publication date: January 24, 2019Inventors: Thomas HIMMLER, Peter BRÜCHNER
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Publication number: 20190023634Abstract: The present invention relates to a method for purifying phenol, which comprises: supplying a feed comprising phenol, acetone, hydroxyacetone and water to a distillation column at 60° C. to 95° C.; separating the feed into a first fraction, which comprises the acetone, and separates to the upper part of the distillation column and a second fraction, which comprises the phenol, and separates to the lower part of the distillation column; and recovering the first fraction and the second fraction, respectively.Type: ApplicationFiled: November 10, 2017Publication date: January 24, 2019Inventors: Si Nae LEE, Sung Kyu LEE, Joon Ho SHIN
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Publication number: 20190023635Abstract: The present invention relates generally to narrow range alcohol alkoxylates and derivatives thereof, such as alkyl ether sulfates.Type: ApplicationFiled: September 24, 2018Publication date: January 24, 2019Inventors: Karunakaran NARASIMHAN, Manuel G VENEGAS, Saurabh MATHUR, Ralf LANGE, Muhammad Sofian bin ASI SIHOMBING
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Publication number: 20190023636Abstract: A method of producing 1,5-pentanedial having an alkyl group at the 3-position, including a step of hydroformylating an aldehyde compound represented by the following general formula (1): wherein R1 represents an alkyl group having from 1 to 6 carbon atoms.Type: ApplicationFiled: February 23, 2017Publication date: January 24, 2019Applicant: KURARAY CO., LTD.Inventors: Takuo TSURUTA, Naoya MINAMOTO, Toshihiro OMATSU
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Publication number: 20190023637Abstract: Embodiments of the present invention relate to processes for the hydroformylation of olefins to produce aldehydes. In some embodiments, processes of the present invention are capable of maintaining high C2-C4 olefin conversion and/or provide more compact hydroformlyation processes.Type: ApplicationFiled: March 15, 2017Publication date: January 24, 2019Applicant: Dow Technology Investments LLCInventors: Kathleen Simpson, Gerald L. Smith
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Publication number: 20190023638Abstract: There is provided a method for producing hydroxypivalaldehyde (HPA), including steps (i) to (iii) below in this order, Step (i): a reaction step of reacting IBAL with FA to produce a reaction solution containing HPA, step (ii): an extraction step of extracting the reaction solution with an aldehyde solvent represented by formula (1) under basicity to obtain an extract containing HPA, and step (iii): a distillation and collection step of distilling the extract and then collecting HPA from the residue, wherein R represents a saturated alkyl group having 3 or more and 7 or less carbon atoms, further wherein the distillation step of the step (iii) is a step of distilling an extract in the presence of water, and an amount of the water which is subjected to the distillation is 100 parts by mass or more and 2,000 parts by mass or less, with respect to a total amount, 100 parts by mass, of isobutyraldehyde (IBAL) derived from a raw material and an aldehyde solvent represented by formula (1) in an extract which isType: ApplicationFiled: January 5, 2017Publication date: January 24, 2019Applicant: Mitsubishi Gas Chemical Company, Inc.Inventors: Yumi SATO, Masahiro YAMANE
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Publication number: 20190023639Abstract: A process for producing oxalic acid containing or having the following steps: i) Utilizing a chemical reaction to produce an alkali metal formate and/or alkaline earth metal formate; ii) Converting the alkali metal formate and/or alkaline earth metal formate to an alkali metal oxalate and/or alkaline earth metal oxalate in a thermal reaction, preferably utilizing hydrogen in the process; iii) Converting the alkali metal oxalate and/or alkaline earth metal oxalate to oxalic acid and an alkali metal base and/or alkaline earth metal base utilizing an electrochemical process; and iv) Recycling the alkali metal base and/or alkaline earth metal base from step (iii) to step (i).Type: ApplicationFiled: January 13, 2017Publication date: January 24, 2019Inventors: Jerry J. Kaczur, Prasad P. Lakkaraju, Rishi R. Parajuli
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Publication number: 20190023640Abstract: The method disclosed herein relates to two stage catalytic processes for converting syngas to acetic acid, acrylic acid and/or propylene. More specifically, the method described and claimed herein relate to a method of producing acrylic acid and acetic acid comprising the steps of: a) providing a feedstream comprising syngas; b) contacting the feedstream with a first catalyst to produce a first product stream comprising C2-C3 olefins and/or C2-C3 paraffins; and c) contacting the first product stream with oxygen gas and a second catalyst, thereby producing a second product stream comprising acrylic acid and acetic acid, wherein there is no step for separating the components of the first product stream before the first product stream is contacted with the second catalyst.Type: ApplicationFiled: September 25, 2018Publication date: January 24, 2019Inventors: Khalid Karim, Labeeb Chaudhary Ahmed
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Publication number: 20190023641Abstract: The present invention relates to the use of at least two phenol derivatives jointly with at least one ancillary polymerization inhibitor which is different from these two phenol derivatives and particularly is selected from phenol derivatives, amine derivatives, thiazine derivatives, nitroso compounds, N-oxyl derivatives, metal salts, quinone derivatives, and mixtures thereof, to inhibit the polymerization of ethylenically unsaturated monomers comprising at least one heteroatom, it being also possible for a dispersant to be incorporated. The present invention also relates to a corresponding polymerization-inhibiting composition and to the corresponding process for preparing ethylenically unsaturated monomers comprising at least one heteroatom, and particularly acrylic monomers.Type: ApplicationFiled: September 7, 2015Publication date: January 24, 2019Inventors: Christelle CHRETIEN, Karel VITS, Lars FISCHER, Yan SHI
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Publication number: 20190023642Abstract: Polymerization inhibitor compositions are provided. The polymerization inhibitor compositions may include at least one hydroxylamine of a nitroxide and at least one phenylenediamine. Methods of inhibiting the unwanted polymerization of monomers are also provided. The methods include adding the presently disclosed polymerization inhibitor compositions to a fluid containing the monomers. The monomers may be ethylenically unsaturated monomers, such as acrylic acid, methacrylic acid, acrylonitrile, methacrylonitrile, acrolein, methacrolein, acrylate, methacrylate, acrylamide, methacrylamide, vinyl acetate, butadiene, ethylene, propylene, and styrene.Type: ApplicationFiled: September 27, 2018Publication date: January 24, 2019Applicant: ECOLAB USA, INC.Inventor: David Youdong Tong
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Publication number: 20190023643Abstract: A compound of formula I wherein R1, R2, R3 and R4 can be independently selected from H or Me, n=0, 1, the dotted lines are indicating single bonds, or in case n=0 an isolated double bond at position 3?, or in case n=1 an isolated double bond at position 3? or 4?, and the wavy bond is indicating an unspecified configuration of the adjacent double bond. Said compounds, as well as precursors capable to generate said compounds, are useful as fragrance ingredients.Type: ApplicationFiled: February 15, 2017Publication date: January 24, 2019Inventors: Andreas Goeke, Felix FLACHSMANN, Dominique LELIEVRE, Andreas NATSCH, Francis VOIROL, Yue ZOU
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Publication number: 20190023644Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.Type: ApplicationFiled: June 3, 2016Publication date: January 24, 2019Applicant: Rutgers, The State University of New JerseyInventors: Durgadas BOLIKAL, Joachim B. KOHN
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Publication number: 20190023645Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.Type: ApplicationFiled: January 5, 2017Publication date: January 24, 2019Applicants: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Mouâd ALAMI, Abdallah HAMZE, Jean-Daniel BRION, Jérôme BIGNON, Joëlle DUBOIS
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Publication number: 20190023646Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.Type: ApplicationFiled: November 24, 2016Publication date: January 24, 2019Inventors: François GUERARD, Jean-François GESTIN, Martin W. BRECHBIEL, Yong-Sok LEE
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Publication number: 20190023647Abstract: The invention relates to a method for the preparation of di- and polyamines of the diphenylmethane series, care being taken during the shutdown of the production process that an excess of aniline and respect to formalin is ensured.Type: ApplicationFiled: September 24, 2018Publication date: January 24, 2019Inventors: Thomas Knauf, Stefan Wershofen, Klaus-Gerd Gruner, Volker Hartjes
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Publication number: 20190023648Abstract: A compound is represented by the following formula (1). In the formula (1), Ar is a substituted or unsubstituted aryl group including 6 to 30 ring carbon atoms, Ra are independently a substituted or unsubstituted alkyl group including 1 to 15 carbon atoms, or a substituted or unsubstituted cycloalkyl group including 3 to 15 carbon atoms, Rb1 to Rb4 are independently a halogen atom, a cyano group, a substituted or unsubstituted alkyl group including 1 to 15 carbon atoms, or the like, Rc1 to Rc10 are independently a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group including 1 to 15 carbon atoms, or the like, * is a bonding position at which one of Rc1 to Rc10 is bonded to either nitrogen atom, x is an integer from 0 to 3, y is an integer from 0 to 4, and z are independently an integer from 0 to 5.Type: ApplicationFiled: September 25, 2018Publication date: January 24, 2019Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Hirokatsu ITO, Masahiro KAWAMURA, Yumiko MIZUKI, Tasuku HAKETA, Tomoharu HAYAMA, Ryota TAKAHASHI
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Publication number: 20190023649Abstract: Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.Type: ApplicationFiled: July 27, 2018Publication date: January 24, 2019Applicant: Bikam Pharmaceuticals, Inc.Inventors: David S. Garvey, Judd Berman, Tan Quach
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Publication number: 20190023650Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.Type: ApplicationFiled: September 13, 2016Publication date: January 24, 2019Inventors: Sandeep Patil, Ron Bihovsky, Steven A. Smith, Yuhua JI, Valentino Stella, Daniel D. Long, Daniel Marquess
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Publication number: 20190023651Abstract: The present application relates to compounds and methods for reducing the severity of convulsant activity, or epileptic seizures.Type: ApplicationFiled: September 20, 2018Publication date: January 24, 2019Inventors: Michael POULTER, Tony DURST
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Publication number: 20190023652Abstract: The present disclosure describes a method of synthesizing carbodiimides comprising providing an alkylisothiourea, providing a thiophilic reagent to the reaction mixture and reacting under conditions sufficient to provide the carbodiimide, and wherein the carbodiimide is a polycarbodiimide or a biscarbodiimide. The present disclosure further describes methods for isolating the carbodiimides. The present disclosure additionally describes isolated carbodiimide compositions.Type: ApplicationFiled: March 8, 2017Publication date: January 24, 2019Inventors: Andrew M. Camelio, Arkady L. Krasovskiy
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Publication number: 20190023653Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Inventor: Martin Reid JOHNSON
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Publication number: 20190023654Abstract: The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof.Type: ApplicationFiled: January 24, 2017Publication date: January 24, 2019Inventors: Jiong LAN, Fusheng ZHOU, Jinzhu ZHAO, Dong HUANG, Jing XIE, Yi HU, Qiang LV
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Publication number: 20190023655Abstract: The present invention, relates to solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.Type: ApplicationFiled: August 26, 2016Publication date: January 24, 2019Inventors: Srinivasan THIRUMALAI RAJAN, Sajja ESWARAIAH, Ghojala VENKAT REDDY, Rebelli PRADEEP