Patents Issued in January 24, 2019
  • Publication number: 20190023606
    Abstract: Intermediate to high CTE glass compositions and laminates formed from the same are described. The glasses described herein have properties, such as liquidus viscosity or liquidus temperature, which make them particularly well suited for use in fusion forming processes, such as the fusion down draw process and/or the fusion lamination process. Further, the glass composition may be used in a laminated glass article, such as a laminated glass article formed by a fusion laminate process, to provide strengthened laminates via clad compression as a result of CTE mismatch between the core glass and clad glass.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Inventors: Timothy James Kiczenski, John Christopher Mauro, Michelle Diane Pierson-Stull, Robert Anthony Schaut, Natesan Venkateraman
  • Publication number: 20190023607
    Abstract: It is related to a metal/polymer nanocomposite film comprising gold nanoparticle which has gold mirror feature, comprises acrylic based oligomer, acrylic based monomer, 2-mercapto thioxanthone which is an one-component type II. radicalic photoinitiator and chloroauric acid.
    Type: Application
    Filed: December 28, 2016
    Publication date: January 24, 2019
    Inventors: Nergis ARSU, Tolga CEPER
  • Publication number: 20190023608
    Abstract: A vehicle glazing includes on its surface to be exposed to the exterior atmosphere, at least in a zone not wiped by the windscreen wipers, a mineral oxide layer of 0.1 to 20 ?m thickness, 30 to 90% of the volume of which consists of 20 to 300 nm open pores that are distributed uniformly throughout the thickness of the layer, and almost all of which are connected to one another, the internal and external surface of the layer being functionalized with a compound containing a perfluoroalkyl or alkyl functional group, then saturated with a hydrophobic oil that impregnates the functionalized porous layer and forms a film on the surface thereof, the at least one zone being located facing a detecting device such as an anti-collision/obstacle-detecting/security video camera, or similar, placed in the interior of the vehicle, in particular on the face of the glazing.
    Type: Application
    Filed: September 6, 2016
    Publication date: January 24, 2019
    Inventors: Barbara BRUDIEU, François GUILLEMOT, Jérémie TEISSEIRE
  • Publication number: 20190023609
    Abstract: An optical component according to an embodiment of the present invention includes a translucent substrate, one or more intermediate layers stacked on at least one of an incident surface and an exit surface of the substrate, and a surface layer stacked on an outermost layer of the one or more intermediate layers, the surface layer containing diamond-like carbon as a main component. At least one intermediate layer among the one or more intermediate layers contains silicon as a main component, and the intermediate layer containing silicon as a main component has an oxygen content of 10 atomic % or less.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 24, 2019
    Inventors: Ryota YAMAGUCHI, Soichiro OKUBO
  • Publication number: 20190023610
    Abstract: A transparent pane comprising a transparent substrate and an electrically conductive coating on a surface of the transparent substrate is disclosed. The electrically conductive coating comprises four functional layers arranged one atop another. Each functional layer comprises a layer of optically highly refractive material with a refractive index >1.3, a first matching layer above the layer of optically highly refractive material, an electrically conductive layer above the first matching layer, and a second matching layer above the electrically conductive layer. The layer thickness of each conductive layer can be 5 nm to 25 nm and the total layer thickness of all electrically conductive layers can be 20 nm to 100 nm.
    Type: Application
    Filed: March 20, 2017
    Publication date: January 24, 2019
    Inventors: Klaus FISCHER, Matthias KUEHNE, Sandra HORNSCHUH, Roberto ZIMMERMANN, Martin HENSELER, Dagmar SCHAEFER, Michael JANSEN
  • Publication number: 20190023611
    Abstract: Asymmetrically strengthened glass articles, methods for producing the same, and use of the articles in portable electronic device is disclosed. The asymmetrically strengthened glass articles include glass articles having a deeper compressive stress layer in a thicker portion of the glass article. Using a budgeted amount of compressive stress and tensile stress, asymmetric chemical strengthening is optimized for the utility of a glass article. In some aspects, the strengthened glass article can be designed for reduced damage, or damage propagation, when dropped.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Inventors: Victor Luzzato, Christopher D. Prest, Dale N. Memering, Matthew S. Rogers
  • Publication number: 20190023612
    Abstract: Disclosed are product (e.g., board), slurry, and methods relating to an uncooked starch that can be used to enhance strength in one or more gypsum layers in the board. The uncooked starch has a hot water viscosity of from about 20 BU to about 300 BU according to the HWVA method, and/or a mid-range peak viscosity of from about 120 Brabender Units to about 1000 Brabender Units.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 24, 2019
    Applicant: United States Gypsum Company
    Inventors: Yijun SANG, Brian J. CHRIST
  • Publication number: 20190023613
    Abstract: Disclosed is a reaction resin composition comprising: a radically polymerizable compound; an initiator system having an a-halo carboxylic acid ester and a catalyst system containing a copper (II) salt, a reducing agent and at least one ligand containing nitrogen; a hydraulically curing compound; and water. Also disclosed is a two- or multi-component system containing said reaction resin composition and uses of said composition for construction applications.
    Type: Application
    Filed: December 15, 2016
    Publication date: January 24, 2019
    Inventors: Angel JIMENEZ, Mickael GALLEF, Armin PFEIL
  • Publication number: 20190023614
    Abstract: Disclosed are product (e.g., panels), slurry, and methods relating to an uncooked starch having a mid-range peak viscosity (i.e., from about 120 Brabender Units to about 900 Brabender Units).
    Type: Application
    Filed: March 23, 2018
    Publication date: January 24, 2019
    Inventors: Yijun SANG, Brian J. CHRIST
  • Publication number: 20190023615
    Abstract: Compositions for the treatment of flue gas desulfurization scrubber effluent may generally comprise, based on weight percent of the composition, at least 50% fly ash, up to 20% calcium oxide and/or calcium hydroxide, up to 2% plasticizer and a balance of incidental impurities. Methods for the treatment of flue gas desulfurization scrubber effluent using the composition for the treatment of flue gas desulfurization scrubber effluent are also described.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 24, 2019
    Applicant: Carmeuse North America
    Inventors: Dale C. Andrews, Lance Olson
  • Publication number: 20190023616
    Abstract: A polycrystalline dielectric thin film and capacitor element has a small dielectric loss tan ?. The polycrystalline dielectric thin film, in which the main composition is a perovskite oxynitride. The perovskite oxynitride is expressed by the compositional formula AaBbOoNn (a+b+o+n=5), where a/b>1 and n?0.7.
    Type: Application
    Filed: February 1, 2017
    Publication date: January 24, 2019
    Applicant: TDK CORPORATION
    Inventors: Kumiko YAMAZAKI, Hiroshi CHIHARA, Yuki NAGAMINE, Junichi YAMAZAKI
  • Publication number: 20190023617
    Abstract: A ceramic matrix composite article includes a melt infiltration ceramic matrix composite substrate comprising a ceramic fiber reinforcement material in a ceramic matrix material having a free silicon proportion, and a chemical vapor infiltration ceramic matrix composite outer layer comprising a ceramic fiber reinforcement material in a ceramic matrix material having essentially no free silicon proportion disposed on an outer surface of at least a portion of the substrate.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventors: Krishan Lal Luthra, Gregory Scot Corman, Badri Narayan Ramamurthi
  • Publication number: 20190023618
    Abstract: A method for making a composite material includes disposing a quantity of liquid comprising at least 90 weight percent molten boron within pores of a porous preform, the preform comprising a preform material; and reacting at least a portion of the molten boron with a portion of the preform material to form a solid ceramic reaction product, thereby forming a ceramic matrix composite material. An article comprises a composite material; the composite material comprises a fibrous phase disposed within a matrix. The matrix comprises silicon carbide, boron carbide, and boron silicide.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 24, 2019
    Inventor: Gregory Scot Corman
  • Publication number: 20190023619
    Abstract: The present invention relates to a copper-ceramic composite comprising—a ceramic substrate which contains aluminum oxide, the aluminum oxide having particle sizes in the range of 0.01 ?m to 25 ?m and a quantity distribution of the particle sizes with a median value d50 and an arithmetic mean value darith, and the ratio of d50 to darith being in the range of 0.75 to 1.10, —a coating made of copper or a copper alloy provided on the ceramic substrate.
    Type: Application
    Filed: February 16, 2017
    Publication date: January 24, 2019
    Inventors: KAI Herbst, Christian Muschelknautz
  • Publication number: 20190023620
    Abstract: A blended composition for use as an admixture for cementitious materials, compressing polystyrene dissolved in a cyclic terpene, and capable of modifying the strength, plasticity, and water-permeability of the cement.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: Darrin Vogeli, Molly Wells Vogeli
  • Publication number: 20190023621
    Abstract: Some examples include a turbine component comprising: a ceramic composite (CMC) having a matrix; and a watertight coating chemically miscible and/or mutually soluble with/in the CMC because particles and/or fibers which are composed of an identical or chemically matching, but at least chemically compatible. At least part of the watertight coating is incorporated in the matrix of the CMC, the matching and compatible material comprising at least one of: aluminum oxide, yttrium aluminum garnet (YAG), and yttrium-stabilized zirconium oxide (YSZ).
    Type: Application
    Filed: January 11, 2017
    Publication date: January 24, 2019
    Applicant: Siemens Aktiengesellschaft
    Inventors: Gia Khanh Pham, Niels Van der Laag
  • Publication number: 20190023622
    Abstract: The invention herein provides a composite material suitable for the absorption of moisture in natural outside areas. More particularly, the composite material can be applied to both grassy and non-grassy natural areas to both absorb any excessive, apparent moisture therein and to also enrich the underlying earth of both grassy and non-grassy natural areas.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 24, 2019
    Inventor: DERRICK ROBERT MAYES
  • Publication number: 20190023623
    Abstract: A composition, in the form of an aqueous suspension. The composition comprises at least one form of attapulgite present in a solid weight fraction (SWF) amount ranging from 0.065% to 0.30%. The composition comprises kaolin present in a percent solids by weight (w/w %) amount ranging from 0.80% to 2.80%. The composition comprises one or more main plant nutrients or major animal mineral nutrient supplements. In the composition, the total percent solids by weight (w/w %) amount in the composition ranges from 45% to 90%. Although usable for other purposes, the composition is usable as a fertilizer. Although makeable in other ways, the composition is makeable by mixing the ingredients with agitation sufficient enough to form an aqueous suspension.
    Type: Application
    Filed: August 4, 2016
    Publication date: January 24, 2019
    Inventors: Steven B. FELDMAN, Jeffery CARR, JR., Matthew J. LYMAN, John KITCHENS, Luke FUHRMANN, Robert J. PURCELL, JR., Dennis . PARKER
  • Publication number: 20190023624
    Abstract: The present application relates to systems and methods for processing organic material. The methods may include extraction of biochemical nutrients from organic material, such as food scraps. The method can include comminuting the organic material to form a slurry from components comprising liquid and organic material; combining the slurry with microorganisms, such as a yeast, under aerobic conditions to form a mixture of the slurry and yeast; aerating the mixture; and forming a biomass and a nutrient-rich broth, in which the biochemical nutrients are stabilized and anabolized. The systems may, in some embodiments, be configured to perform the methods of processing organic materials.
    Type: Application
    Filed: July 31, 2018
    Publication date: January 24, 2019
    Applicant: WISErg Corporation
    Inventors: Larry LeSueur, Jose Lugo, Ken Deering, Victor V. Tryon, Michael Bridges, Lee Wilkerson, Trevor Lewis
  • Publication number: 20190023625
    Abstract: The present invention provides a vertical gas distribution device for aerobic compost and a gas distribution method. Current gas distribution pipelines are easily blocked by organic materials, resulting in poor ventilation due to non-uniform local ventilation and cleaning difficulties. The inventive device comprises a compost chamber, a compost bin, a compost heap, a percolate tank, and a plurality of gas distribution branch pipes at the bottom of the compost chamber, the pipes being vertically movable in the chamber; the percolate tank is positioned at the bottom of the chamber and under the pipes; an air inlet is provided on the side wall of the tank, and an outlet is provided on the side wall of the chamber; the compost bin is inside the compost chamber, and the compost heap is in the compost bin; each pipe is top sealed, with a plurality of vent holes on the side wall, and its bottom connected to the tank. The present invention is usable for compost ventilation.
    Type: Application
    Filed: June 6, 2018
    Publication date: January 24, 2019
    Inventors: Zimin Wei, Beidou Xi, Baiyan Cai, Xu Zhang, Dan Wei, Liming Jia, Xinyu Zhao, Mingxiao Li, Tianxue Yang, Yue Zhao
  • Publication number: 20190023626
    Abstract: Provided is a coated granular fertilizer, which includes a granular fertilizer and a resin coat that coats the granular fertilizer, in which the resin coat contains a urethane resin that is a polyaddition product between a polyisocyanate component and a polyol component, the polyisocyanate component includes an aromatic polyisocyanate, and the polyol component includes a castor oil-modified diol, an alkylene diol having 2 to 8 carbon atoms, and a compound having three or more hydroxyl groups.
    Type: Application
    Filed: September 1, 2016
    Publication date: January 24, 2019
    Applicant: Sumitomo Chemical Company, Limited
    Inventor: Mitsuhiro SASAKAWA
  • Publication number: 20190023627
    Abstract: Aspects of the invention include compositions for controlling plant parasitic nematodes. Compositions according to certain embodiments include a carbon skeleton energy compound, a chelating agent, macronutrients, micronutrients, an ionophore, exotic micronutrients and a plant parasitic nematode antagonist. Methods for using the compositions of the invention to control plant parasitic nematodes and kits having one or more compositions for controlling plant parasitic nematodes are also described.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 24, 2019
    Inventor: Thomas T. Yamashita
  • Publication number: 20190023628
    Abstract: The invention relates to a cast explosive composition comprising a polymer-bonded explosive and a defoaming agent, and to a process for reducing the number and/or total volume of voids in a cast explosive composition comprising the steps of: combining a polymer-bonded explosive and a defoaming agent; and casting the explosive composition. The defoaming agent may be used for reducing the number and/or total volume of voids in a cast explosive composition and the cast explosive composition may be used in an explosive product.
    Type: Application
    Filed: November 29, 2017
    Publication date: January 24, 2019
    Applicant: BAE SYSTEMS plc
    Inventors: Ronald Edward HOLLANDS, Ian Ewart Paterson MURRAY
  • Publication number: 20190023629
    Abstract: A priming mix composition includes between about 30% and about 60% of at least one of KDNBF, dinol, and tetrazene as a primary explosive; between about 10% and about 35% of a metallocene as a propagation aid; between about 5% and about 40% of at least one nitrate, peroxide, or oxide, as an oxidizer; between about 5% and about 25% of at least one of nitrocellulose or PETN as a reactive fuel; and a fuel. The metallocene is preferable ferrocene.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 24, 2019
    Inventors: Toni M. Whaley, Morris C. Buenemann, JR., George C. Mei
  • Publication number: 20190023630
    Abstract: A high strength engineered reactive matrix composite that includes a core material and a reactive binder matrix combined in high volumes and with controlled spacing and distribution to produce both high strength and controlled reactivity. The engineered reactive matrix composite includes a repeating metal, ceramic, or composite particle core material and a reactive binder/matrix, and wherein the reactive/matrix binder is distributed relatively homogeneously around the core particles, and wherein the reactivity of the reactive binder/matrix is engineered by controlling the relative chemistry and interfacial surface area of the reactive components. These reactive materials are useful for oil and gas completions and well stimulation processes, enhanced oil and gas recovery operations, as well as in defensive and mining applications requiring high energy density and good mechanical properties.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventors: Andrew J. Sherman, Brian P. Doud
  • Publication number: 20190023631
    Abstract: The present invention provides improved processes for preparing halogenated alkanes. In particular, the processes comprise reacting an alkene, a halogenated alkene, or combinations thereof and a halogenated methane with at least one chlorine atom.
    Type: Application
    Filed: January 4, 2017
    Publication date: January 24, 2019
    Inventors: John D. Myers, Max M. Tirtowidjojo, Thomas U. Luebbe, Marc M. Sell
  • Publication number: 20190023632
    Abstract: A process is described for producing 1,3-butanediol, wherein an ester of poly-(R)-3-hydroxybutyrate such as formed by transesterification with an alcohol is reduced by hydrogenation in the presence of a skeletal copper-based catalyst to provide 1,3-butanediol. The 1,3-butanediol may be transesterified by reaction with additional poly-(R)-3-hydroxybutyrate ester to produce (R)-3-hydroxybutyl (R)-3-hydroxybutyrate.
    Type: Application
    Filed: December 8, 2016
    Publication date: January 24, 2019
    Inventors: Paul Bloom, Chi Cheng Ma, Kevin Martin, Brennan Smith
  • Publication number: 20190023633
    Abstract: The invention relates to a process for preparing substituted 2-arylethanols of the formula (I) by reacting Grignard compounds of the formula (II) in the presence of a copper compound with ethylene oxide. Moreover, the invention relates to novel substituted 2-arylethanols of the formula (I).
    Type: Application
    Filed: January 9, 2017
    Publication date: January 24, 2019
    Inventors: Thomas HIMMLER, Peter BRÜCHNER
  • Publication number: 20190023634
    Abstract: The present invention relates to a method for purifying phenol, which comprises: supplying a feed comprising phenol, acetone, hydroxyacetone and water to a distillation column at 60° C. to 95° C.; separating the feed into a first fraction, which comprises the acetone, and separates to the upper part of the distillation column and a second fraction, which comprises the phenol, and separates to the lower part of the distillation column; and recovering the first fraction and the second fraction, respectively.
    Type: Application
    Filed: November 10, 2017
    Publication date: January 24, 2019
    Inventors: Si Nae LEE, Sung Kyu LEE, Joon Ho SHIN
  • Publication number: 20190023635
    Abstract: The present invention relates generally to narrow range alcohol alkoxylates and derivatives thereof, such as alkyl ether sulfates.
    Type: Application
    Filed: September 24, 2018
    Publication date: January 24, 2019
    Inventors: Karunakaran NARASIMHAN, Manuel G VENEGAS, Saurabh MATHUR, Ralf LANGE, Muhammad Sofian bin ASI SIHOMBING
  • Publication number: 20190023636
    Abstract: A method of producing 1,5-pentanedial having an alkyl group at the 3-position, including a step of hydroformylating an aldehyde compound represented by the following general formula (1): wherein R1 represents an alkyl group having from 1 to 6 carbon atoms.
    Type: Application
    Filed: February 23, 2017
    Publication date: January 24, 2019
    Applicant: KURARAY CO., LTD.
    Inventors: Takuo TSURUTA, Naoya MINAMOTO, Toshihiro OMATSU
  • Publication number: 20190023637
    Abstract: Embodiments of the present invention relate to processes for the hydroformylation of olefins to produce aldehydes. In some embodiments, processes of the present invention are capable of maintaining high C2-C4 olefin conversion and/or provide more compact hydroformlyation processes.
    Type: Application
    Filed: March 15, 2017
    Publication date: January 24, 2019
    Applicant: Dow Technology Investments LLC
    Inventors: Kathleen Simpson, Gerald L. Smith
  • Publication number: 20190023638
    Abstract: There is provided a method for producing hydroxypivalaldehyde (HPA), including steps (i) to (iii) below in this order, Step (i): a reaction step of reacting IBAL with FA to produce a reaction solution containing HPA, step (ii): an extraction step of extracting the reaction solution with an aldehyde solvent represented by formula (1) under basicity to obtain an extract containing HPA, and step (iii): a distillation and collection step of distilling the extract and then collecting HPA from the residue, wherein R represents a saturated alkyl group having 3 or more and 7 or less carbon atoms, further wherein the distillation step of the step (iii) is a step of distilling an extract in the presence of water, and an amount of the water which is subjected to the distillation is 100 parts by mass or more and 2,000 parts by mass or less, with respect to a total amount, 100 parts by mass, of isobutyraldehyde (IBAL) derived from a raw material and an aldehyde solvent represented by formula (1) in an extract which is
    Type: Application
    Filed: January 5, 2017
    Publication date: January 24, 2019
    Applicant: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yumi SATO, Masahiro YAMANE
  • Publication number: 20190023639
    Abstract: A process for producing oxalic acid containing or having the following steps: i) Utilizing a chemical reaction to produce an alkali metal formate and/or alkaline earth metal formate; ii) Converting the alkali metal formate and/or alkaline earth metal formate to an alkali metal oxalate and/or alkaline earth metal oxalate in a thermal reaction, preferably utilizing hydrogen in the process; iii) Converting the alkali metal oxalate and/or alkaline earth metal oxalate to oxalic acid and an alkali metal base and/or alkaline earth metal base utilizing an electrochemical process; and iv) Recycling the alkali metal base and/or alkaline earth metal base from step (iii) to step (i).
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventors: Jerry J. Kaczur, Prasad P. Lakkaraju, Rishi R. Parajuli
  • Publication number: 20190023640
    Abstract: The method disclosed herein relates to two stage catalytic processes for converting syngas to acetic acid, acrylic acid and/or propylene. More specifically, the method described and claimed herein relate to a method of producing acrylic acid and acetic acid comprising the steps of: a) providing a feedstream comprising syngas; b) contacting the feedstream with a first catalyst to produce a first product stream comprising C2-C3 olefins and/or C2-C3 paraffins; and c) contacting the first product stream with oxygen gas and a second catalyst, thereby producing a second product stream comprising acrylic acid and acetic acid, wherein there is no step for separating the components of the first product stream before the first product stream is contacted with the second catalyst.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 24, 2019
    Inventors: Khalid Karim, Labeeb Chaudhary Ahmed
  • Publication number: 20190023641
    Abstract: The present invention relates to the use of at least two phenol derivatives jointly with at least one ancillary polymerization inhibitor which is different from these two phenol derivatives and particularly is selected from phenol derivatives, amine derivatives, thiazine derivatives, nitroso compounds, N-oxyl derivatives, metal salts, quinone derivatives, and mixtures thereof, to inhibit the polymerization of ethylenically unsaturated monomers comprising at least one heteroatom, it being also possible for a dispersant to be incorporated. The present invention also relates to a corresponding polymerization-inhibiting composition and to the corresponding process for preparing ethylenically unsaturated monomers comprising at least one heteroatom, and particularly acrylic monomers.
    Type: Application
    Filed: September 7, 2015
    Publication date: January 24, 2019
    Inventors: Christelle CHRETIEN, Karel VITS, Lars FISCHER, Yan SHI
  • Publication number: 20190023642
    Abstract: Polymerization inhibitor compositions are provided. The polymerization inhibitor compositions may include at least one hydroxylamine of a nitroxide and at least one phenylenediamine. Methods of inhibiting the unwanted polymerization of monomers are also provided. The methods include adding the presently disclosed polymerization inhibitor compositions to a fluid containing the monomers. The monomers may be ethylenically unsaturated monomers, such as acrylic acid, methacrylic acid, acrylonitrile, methacrylonitrile, acrolein, methacrolein, acrylate, methacrylate, acrylamide, methacrylamide, vinyl acetate, butadiene, ethylene, propylene, and styrene.
    Type: Application
    Filed: September 27, 2018
    Publication date: January 24, 2019
    Applicant: ECOLAB USA, INC.
    Inventor: David Youdong Tong
  • Publication number: 20190023643
    Abstract: A compound of formula I wherein R1, R2, R3 and R4 can be independently selected from H or Me, n=0, 1, the dotted lines are indicating single bonds, or in case n=0 an isolated double bond at position 3?, or in case n=1 an isolated double bond at position 3? or 4?, and the wavy bond is indicating an unspecified configuration of the adjacent double bond. Said compounds, as well as precursors capable to generate said compounds, are useful as fragrance ingredients.
    Type: Application
    Filed: February 15, 2017
    Publication date: January 24, 2019
    Inventors: Andreas Goeke, Felix FLACHSMANN, Dominique LELIEVRE, Andreas NATSCH, Francis VOIROL, Yue ZOU
  • Publication number: 20190023644
    Abstract: Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues and hydroxybenzoic acid, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.
    Type: Application
    Filed: June 3, 2016
    Publication date: January 24, 2019
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Durgadas BOLIKAL, Joachim B. KOHN
  • Publication number: 20190023645
    Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.
    Type: Application
    Filed: January 5, 2017
    Publication date: January 24, 2019
    Applicants: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mouâd ALAMI, Abdallah HAMZE, Jean-Daniel BRION, Jérôme BIGNON, Joëlle DUBOIS
  • Publication number: 20190023646
    Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.
    Type: Application
    Filed: November 24, 2016
    Publication date: January 24, 2019
    Inventors: François GUERARD, Jean-François GESTIN, Martin W. BRECHBIEL, Yong-Sok LEE
  • Publication number: 20190023647
    Abstract: The invention relates to a method for the preparation of di- and polyamines of the diphenylmethane series, care being taken during the shutdown of the production process that an excess of aniline and respect to formalin is ensured.
    Type: Application
    Filed: September 24, 2018
    Publication date: January 24, 2019
    Inventors: Thomas Knauf, Stefan Wershofen, Klaus-Gerd Gruner, Volker Hartjes
  • Publication number: 20190023648
    Abstract: A compound is represented by the following formula (1). In the formula (1), Ar is a substituted or unsubstituted aryl group including 6 to 30 ring carbon atoms, Ra are independently a substituted or unsubstituted alkyl group including 1 to 15 carbon atoms, or a substituted or unsubstituted cycloalkyl group including 3 to 15 carbon atoms, Rb1 to Rb4 are independently a halogen atom, a cyano group, a substituted or unsubstituted alkyl group including 1 to 15 carbon atoms, or the like, Rc1 to Rc10 are independently a hydrogen atom, a halogen atom, a cyano group, a substituted or unsubstituted alkyl group including 1 to 15 carbon atoms, or the like, * is a bonding position at which one of Rc1 to Rc10 is bonded to either nitrogen atom, x is an integer from 0 to 3, y is an integer from 0 to 4, and z are independently an integer from 0 to 5.
    Type: Application
    Filed: September 25, 2018
    Publication date: January 24, 2019
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Hirokatsu ITO, Masahiro KAWAMURA, Yumiko MIZUKI, Tasuku HAKETA, Tomoharu HAYAMA, Ryota TAKAHASHI
  • Publication number: 20190023649
    Abstract: Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 24, 2019
    Applicant: Bikam Pharmaceuticals, Inc.
    Inventors: David S. Garvey, Judd Berman, Tan Quach
  • Publication number: 20190023650
    Abstract: Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.
    Type: Application
    Filed: September 13, 2016
    Publication date: January 24, 2019
    Inventors: Sandeep Patil, Ron Bihovsky, Steven A. Smith, Yuhua JI, Valentino Stella, Daniel D. Long, Daniel Marquess
  • Publication number: 20190023651
    Abstract: The present application relates to compounds and methods for reducing the severity of convulsant activity, or epileptic seizures.
    Type: Application
    Filed: September 20, 2018
    Publication date: January 24, 2019
    Inventors: Michael POULTER, Tony DURST
  • Publication number: 20190023652
    Abstract: The present disclosure describes a method of synthesizing carbodiimides comprising providing an alkylisothiourea, providing a thiophilic reagent to the reaction mixture and reacting under conditions sufficient to provide the carbodiimide, and wherein the carbodiimide is a polycarbodiimide or a biscarbodiimide. The present disclosure further describes methods for isolating the carbodiimides. The present disclosure additionally describes isolated carbodiimide compositions.
    Type: Application
    Filed: March 8, 2017
    Publication date: January 24, 2019
    Inventors: Andrew M. Camelio, Arkady L. Krasovskiy
  • Publication number: 20190023653
    Abstract: Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (SO2F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FSO2NMe2), tetramethylsulfamide (SO2(NMe2)2), or a combination thereof. A second phase, which may include dimethylamine hydrofluoride (Me2NH2F), may be also formed and separated from the first phase. FSO2NMe2 or SO2(NMe2)2 is then isolated from the first phase. For example, the first phase may be a liquid phase, and FSO2NMe2 and SO2(NMe2)2 are separated by distillation, optionally under reduced pressure.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventor: Martin Reid JOHNSON
  • Publication number: 20190023654
    Abstract: The present invention discloses an N-sulfonyl benzamide derivative with a heterocyclic substituent, and a preparation method therefor and a pharmaceutical application thereof. More specifically, the invention discloses a compound represented by formula (II) or a pharmaceutically acceptable salt, stereoisomer, solvent compound, or prodrug thereof, and a preparation method therefor and an application thereof.
    Type: Application
    Filed: January 24, 2017
    Publication date: January 24, 2019
    Inventors: Jiong LAN, Fusheng ZHOU, Jinzhu ZHAO, Dong HUANG, Jing XIE, Yi HU, Qiang LV
  • Publication number: 20190023655
    Abstract: The present invention, relates to solid state forms of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.
    Type: Application
    Filed: August 26, 2016
    Publication date: January 24, 2019
    Inventors: Srinivasan THIRUMALAI RAJAN, Sajja ESWARAIAH, Ghojala VENKAT REDDY, Rebelli PRADEEP