Abstract: A method of treating a bladder condition is provided. The method is effected by circulating a volume of heated fluid through a urinary bladder of a subject in need and gradually increasing the volume of fluid up to a predetermined fluid volume and or pressure.

Abstract: A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial.

Abstract: System for trans-dermal delivery of doses of a medicament, comprising a delivery device to be placed in dermal contact with a patient, the delivery device comprising a reservoir for holding a medicament to be delivered, a trans-dermal injection element for delivering doses of the medicament to the patient, a control unit for controlling the delivery of the medicament when activated, the system further comprising a separate hand-held drive device to be temporarily placed in proximity of the delivery device when a dose of medicament is required, the drive device comprising an activation unit for activating the control unit of the delivery device.

Abstract: A fluid infusion device is provided. The device comprises a drive system that includes a movable slide. The slide includes a first coupling device. The device also comprises a fluid reservoir that includes a stopper movable relative to the fluid reservoir by the slide to advance a fluid out of the fluid reservoir. The stopper includes a second coupling device that cooperates with the first coupling device to resist the movement of the stopper relative to the slide.

Abstract: An indwelling assembly includes an inner needle having a sharp needlepoint, an inner needle hub fixed to the inner needle, a hollow elongated outer member in which the inner needle is positioned and movable in a distal direction relative to the inner needle after puncturing the blood vessel to position the elongated outer member at a desired position in the blood vessel, an outer member hub fixed to hollow elongated outer member, a projection removably connected to the outer member hub and configured to be engaged by a finger of the user to apply a force to the projection causing the outer member hub and the hollow elongated outer member to move together with the projection in the distal direction relative to the inner needle and the inner needle hub, and an elongated movable member that is movable relative to the hollow elongated outer member and the outer member hub.

Abstract: A system for confirmation of fluid delivery to a patient at the clinical point of use is provided. The system includes a wearable electronic device. The wearable electronic device has a housing; at least one imaging sensor associated with the housing; a data transmission interface; a data reporting accessory for providing data to the user; a microprocessor for managing the at least one imaging sensor, the data transmission interface, and the data reporting accessory; and a program for acquiring and processing images from the at least one imaging sensor. The system further includes a fluid delivery apparatus; and one or more identification tags attached to or integrally formed with the fluid delivery apparatus. The program processes an image captured by the at least one imaging sensor to identify the one or more identification tags and acquires fluid delivery apparatus information from the one or more identification tags.

Abstract: A method of infusing a fluid includes receiving values of one or more infusion parameters for an infusion of a fluid, Based on the received infusion parameter values, an occlusion pressure threshold for the infusion of the fluid is automatically calculated. During the infusion, a fluid pressure value is sensed. An indication is provided responsive to whether a value of the sensed fluid pressure is greater than the occlusion pressure threshold.

Abstract: A system is provided with an insulin delivery device configured to deliver insulin to a user of the system and a computer-based control unit associated with the insulin delivery device. The computer-based control unit includes a user interface and a computer-based processor. The computer-based processor is configured to calculate a relative insulin on board value for a specific time by calculating a first value that represents a reference insulin on board value at the specific time, calculating a second value that represents an automated insulin on board value at the specific time, and subtracting one of the first and second values from the other. The automated insulin on board value represents at least one insulin delivery automatically specified by the computer-based control unit. Methods of use are also disclosed.

Abstract: Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting a signal level associated with the monitored physiological condition deviating from a predetermined threshold level, retrieving the medication level administered associated with a time period of the detected signal level, applying the retrieved medication level to the detected signal based on a predefined predictive model to generate a predictive signal, and comparing the detected signal to the predictive signal to determine whether a condition associated with the detected signal level is present are provided.

Abstract: Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient's needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides adaptation of priming dose size at mealtimes for overall better glycemic control and also adapting to longer-term changes in a patient's needs. Adaptation calculations use a receding-horizon window of recent values of the adapted parameter. Doses of a counter-regulatory agent (e.g., glucagon) may also be delivered in response to information about estimated accumulation of exogenously infused insulin (subcutaneously, intramuscularly, intraperitoneally, or intravenously) and/or the effect insulin might have on glucose levels (blood glucose concentration or interstitial fluid glucose concentration).

Abstract: Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The system provides the user with the ability to understand the effects of bolus insulin dosing upon their glucose levels. Specifically, the system provides a message that must include: (a) the trend of the user's glucose; (b) the recommended bolus; and (c) the actual bolus.

Abstract: This pharmaceutical injection device may be provided with a main body case, a pharmaceutical syringe mounting portion, a piston, a piston feed screw or the like, and a cover. At a first end, the main body case may have an injection needle mounting portion to which an injection needle is mounted. The pharmaceutical syringe mounting portion may be provided inside the main body case, and a pharmaceutical syringe may be mounted thereto. The piston may be provided movably with respect to the pharmaceutical syringe that is mounted to the pharmaceutical syringe mounting portion. The piston feed screw or the like drives the piston. The cover may be provided on the first end side of the main body case and operates to open and close the injection needle mounting portion.

Abstract: The present invention relates to a medicament delivery device comprising a housing having opposite distal and proximal ends; a medicament container holder with a medicament container, disposed within the housing, wherein the container has a front opening with or for a delivery member for delivering the medicament therethrough and at least a movable stopper; a drive unit comprising a power source and a plunger rod, wherein said drive unit is arranged to be movable between a non-delivery state in which said power source is in a cocked state and a delivery state in which said power source acts on said plunger rod which in its turn acts on said stopper for delivering a dose of medicament from said medicament container; retaining means operably connected to said drive unit, and capable of holding said drive unit in its non-delivery state; and activation means operably connected to said retaining means, and capable of releasing said drive unit from its non-delivery state; wherein the device further comprises a deli

Abstract: An autoinjector having a body to receive a reservoir and an actuator sleeve including a contact end and extending inside the body and movable relative to the body between projecting positions and an actuated position. The actuator sleeve is in a first projecting position before actuation of the autoinjector and in a second projecting position after actuation. The actuator sleeve, in the second projecting position, extends axially further out from the body than in the first projecting position and includes an annular zone that, in the first projecting position, is arranged inside the body and in the second projecting position is arranged outside the body. The annular zone includes a visual indicator that the autoinjector has been actuated. Axially adjacent the annular zone the actuator sleeve includes a shoulder, projecting radially outwards relative to the visual indicator, thereby protecting the indicator against contact with the inside of the body.

Abstract: A drive assembly comprises a guide nut, a lock, and a fastener, the fastener being movable with respect to the lock into and out of a position, in which the fastener engages the lock with the guide nut.

Abstract: A dose setting mechanism having a locking mechanism for preventing selection of a dose in a drug delivery device is disclosed. The dose setting mechanism includes a locking mechanism that prevents movement of the dose setting mechanism. When a correct cartridge is inserted into the drug delivery device, the locking mechanism unlocks so as to allow movement of the dose setting mechanism. In one arrangement, the locking mechanism prevents rotation of the dose setting mechanism.

Abstract: The disclosure relates to a sheath removal mechanism (15) for removing a protective needle sheath (5) from a medicament container (3), the medicament container (3) arrangeable in an medicament delivery device (1), wherein the sheath removal mechanism (15) comprises a cap (11) attachable to a distal end of the medicament delivery device (1), wherein the cap (11) comprises at least one ledge (11.6) adapted to engage a protective needle sheath (5).

Abstract: A disposable safe vein transfusion puncture needle comprising a needle head (4), a needle base (3), a needle sheath sleeved on the needle head (4), and a hose (6) communicated with the needle base (3), and further comprising a plurality of slidable components (1, 2) and a plurality of limiting mechanisms (11, 12, 13, 21, 31, 32), wherein the needle base (3) is in a tubular shape, with one end stationary and communicated with the needle head (4) and the other end connected to the hose (6); each of the slidable components (1, 2) is in a tubular shape and has two open ends, the plurality of slidable components (1, 2) are sleeved on one another, the innermost slidable component (1) is movably sleeved onto the needle base (3), and a sum of lengths of the plurality of slidable components (1, 2) in a moving direction is longer than the length of the needle head (4); the limiting mechanisms (11, 12, 13, 21, 31, 32) are disposed on the plurality of slidable components (1, 2) as well as on the needle base (3).

Abstract: A needle guard device mountable to a pre-filled syringe in its ready-to-fill state. The device includes a lock collar and a device shield biased to move relative to the lock collar. The lock collar interfaces with the syringe neck to attach the device to the syringe. With the removal of a needle shield assembly comprising rigid and soft needle shields, the lock collar and device shield are free to move proximally along the syringe neck and interact with a syringe step down area to activate the device. As the device moves proximally, retention arms of the device shield interact with the syringe step down, causing the arms to deflect radially outwards to disengage from the lock collar triggering the device shield to move from a first position to a second position.

Abstract: Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents.

Abstract: The invention relates to a drive mechanism (9) for a needle insertion arrangement (1), the drive mechanism (9) being arranged as a bistable mechanism with at least one pivoted link (10, 11) having two stable end positions (LEP, UEP) and an instable transitional central position (CP), the drive mechanism (9) further comprising a spring (12) biasing the link (10, 11) out of the transitional central position (CP), wherein at least one trigger unit (17, 21) is arranged for moving the link (10, 11) out of at least one of the stable end positions (LEP, UEP) towards and beyond the transitional central position (CP) against the bias of the spring (12).

Abstract: Syringe/conduit combination with a syringe part (1) and a conduit part (2). The parts have a male slip fitting (4) and a female slip fitting (5) for press fitted connection. The syringe part (1) has a hollow barrel (22) and a plunger (23) inserted into the barrel (22). The plunger (23) and the hollow barrel (22) have abutments (25, 27) defining a maximally inserted position of the plunger (23). The male slip fitting (4) fits in the female slip fitting (5) such that the male slip fitting (4) is at an axial distance of less than 0.1 mm from an internal end of the female slip fitting (5). The plunger (23) in its maximally inserted position is then at an axial distance from an opposite one of the slip fittings (5) that is equal to or less than the axial distance between the male slip fitting (4) and the internal end (9) of the female slip fitting (5).

Abstract: A motion-compensated injector system includes a handheld tool having a hollow shaft with a distal end for insertion into tissue of a subject. The system also includes an optical coherence tomography-based optical detection system having an optical fiber with a distal end at a fixed distance from the distal end of the hollow shaft, and an optical sensor to receive a signal from the optical fiber. The system further includes an actuator to move the hollow shaft in an axial direction, and a control unit to control the actuator. The optical detection system can monitor a distance between the distal end of the optical fiber and a reference portion of the tissue of the subject, and the control unit can control the actuator to move the hollow shaft to compensate for relative motion between the handheld tool and the portion of the tissue.

Abstract: A medical pump provides programming to assist a patient in complying with treatment schedules involving varying dosages of medicament(s). The pump includes stored treatment schedules and protocols that describe control of flow control device(s) for delivering different medicines according to the protocols and which may provide reminders and instructions to the patient.

Abstract: An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user is disclosed. It comprises an actuating lever and a blister strip drive member rotatably mounted in the chamber to sequentially move each blister into a blister opening position. The blister strip drive member and the actuating lever comprise a drive gear and a drive gear element, respectively, that cooperate to effect rotation of the blister strip drive member in response to rotation of the actuating lever. The drive gear and drive gear element are disposed on the outside of the housing remote from the chamber.

Abstract: A nasal spray device for the delivery of a pharmaceutical formulation to the nasal cavity in metered doses. The device includes: a pressurised aerosol canister including a vial containing a pharmaceutical formulation including an active ingredient, a propellant and, optionally, a co-solvent, the aerosol canister further including a metering valve having a valve stem; and an actuator for the aerosol canister, the actuator including a stem block having a receptacle into which the valve stem of metering valve of the aerosol canister is received and axially located and being displaceable relative to the vial of the aerosol canister to actuate the metering valve of the aerosol canister, a sump extending below the receptacle, the stem block further defining a discharge orifice for the pharmaceutical formulation and a transfer channel through which a dispensed dose of the pharmaceutical formulation is able to pass from the sump to the discharge orifice.

Abstract: A nose clip includes an outer support member adapted to contact an outside surface of a nose; a bridge connected at a first end to the outer support member; and an inner support member connected to a second end of the bridge and adapted to be inserted into the nostril and to contact an inner surface of the nostril. When inserted, tension generated between the outer support member and the inner support member causes lateral movement of a surface within the nostril and opens a nasal airway. Additionally, the inner support can be curved to create an outward movement of the lateral wall of the nose. This in turn enables improved breathing. The nose clip may be made of a malleable material. The inner support member may include extensions that are malleable. The inner support members may be bent so that they create a convex contour of an interior surface of the nasal cavity.

Abstract: A device and a method for artificial respiration in emergencies are proposed. The device comprises respiratory mask (40) which can be placed onto the nose and mouth section of a person to be provided with artificial respiration, a mouth section mouthpiece (41), through which respiratory air from an aider can be supplied, a flow tube (2) disposed between the respiratory mask (40) and the mouthpiece (41), which flow tube forms a continuous flow channel for the supplied respiratory air from the mouthpiece (41) to the respiratory mask (40), at least one sensor (10) disposed in the flow channel of the flow tube (2), which sensor measures parameters of the gases flowing through the flow channel, a processor disposed on the flow tube (2) and an output device (124). Here, the processor processes the mass or volumetric flow registered by the flow sensor (19) to form an output signal. The output device (124) emits the output signal.

Abstract: A surgical mask for administering and/or scavenging medical gases includes a nasal mask and an oral mask that envelops the nasal mask. The nasal mask is secured to the oral mask and may be removable from it.

Abstract: A laryngeal mask including a rigid hollow tube essentially in the form of a “J”, and which has a lengthwise opening along its entire length, and a flexible tube, also essentially in the form of a “J”, configured to be housed in the lengthwise opening of the rigid hollow tube, and which can be separated from it. This provides a configuration for a laryngeal mask that can change from having rigid properties to flexible ones at the doctor's will, without the need to interrupt the patient's supply of oxygen at any time.

Abstract: A tracheal/endotracheal device that has an integrated system for removing mucins and similar infectious secretions. The tracheal/endotracheal device has several channels. One channel delivers air to a patient's lungs. At least two other channels cooperate to deliver a mist of antiseptic ingredients to an area in the trachea and to suction away the mist and any mucins and secretions. The mist and bodily fluids captured by the suctioning channel are delivered to a collection vessel outside of the trachea.

Abstract: The invention relates to a speaking valve for laryngectomized and tracheotomized persons that is easy and economical to produce. According to the invention, the speaking valve comprises a proximal first opening and a distal second opening, a filter, which is at least partially surrounded by the housing, which filter is made of an elastic material, and has a proximal first end and a distal second end, wherein the filter partially protrudes beyond an end face of the housing at the distal second opening, and wherein a cover is connected by means of at least one partial region of the bottom surface thereof to a top side of the filter at the distal second end of the filter.

Abstract: A respiratory mask (10) for delivering inspiratory gas to a wearer, the mask comprising a mask body (12) shaped to define a cavity adapted to fit about the mouth and nose of the patient, wherein the mask body comprises a nose cavity portion (18) and a mouth cavity portion (16), the nose cavity portion comprising an inspiratory gas inlet port (26) and wherein the mouth portion comprises an expiratory gas monitoring port (34) at a location spaced from the inlet port. The gas monitoring port and may comprise an integral connector for a monitoring line and may be used to monitor carbon dioxide levels.

Abstract: A floatable coupling between a patient interface device and a frame body is provided. The floatable coupling includes a number of elastic bands extending between the patient interface device and the frame body. The elastic bands couple the patient interface device and the frame body in a manner that allows the patient interface device to float relative to the frame body.

Abstract: A mask apparatus for a respiratory treatment can permit delivery of breathable gas to a user. In one example, the mask may employ a frame and cushion to form a seal for both mouth and nose. The frame may be adapted for coupling with a respiratory treatment apparatus so as to permit communication of a pressurized gas from the respiratory treatment apparatus. The cushion, which may be foam, may have a substantially under the nose configuration or over the nose configuration. The mask may have a common plenum chamber for both nose and mouth. The cushion may further define a centrally open lip superior region. The cushion may be adapted to couple with the frame directly or to the frame in conjunction with a cushion support clip. Various features of the cushion may further promote sealing and comfort for the under the nose design.

Abstract: Provided is an oxygen concentration device which, as an oxygen concentration device having a reduced difference in flow rates of gas which flows through a pressure equalization valve of a pressure equalization path during a purge step and a pressure equalization step, is provided at at least one end side of the pressure equalization valve with a pressure control member having a difference in pressure loss due to the direction of gas flow so that pressure loss of the gas which flows through the pressure equalization path in one direction becomes nearly equal to that of the gas which flows therethrough in the opposite direction.

Abstract: The present invention relates to a device and method of delivering inhaled Nitric Oxide (iNO) to a patient situated in a Magnetic Resonance Imaging (MRI) suite.

Abstract: A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.

Abstract: A device for use in pulmonary surgery is presented. The device includes a dispensing apparatus 300, 400, 900, a delivery apparatus 100, 1000, 1100, in fluid communication with said dispensing apparatus, and a pressurized gas input 338. The dispensing apparatus is configured to provide a pressurized gas, a fibrinogen stream, and a thrombin stream to the delivery apparatus. The delivery apparatus is configured to mix the fibrogen stream and the thrombin stream in the pressurized gas stream to form a fibrin reaction mixture comprising a cellular foam 700.

Abstract: A humidifier for a respiratory assistance device, is provided wherein at least a portion of an inside of a chamber is exposed to light such that light impinges on a metallic or carbon-based material to generate localized heating of liquid molecules around the metallic or carbon-based material and generate vapour for use by the respiratory assistance device. A respiratory assistance device comprising a humidifier and related methods and apparatus are also provided. Arrangements are provided for generating vapour by impinging light on metallic and/or carbon based material, particularly in the form of nanoparticles.

Abstract: A catheter includes a tubular body having an outer surface, and a sleeve disposed on only a portion of the outer surface of the tubular body. The sleeve includes an outer layer overlying an inner layer. The catheter contains a water-soluble, anti-microbial agent in the outer layer of the sleeve. Methods of making the catheter are also disclosed.

Abstract: A catheter for insertion into a body cavity of a subject (such as the urinary bladder), and having a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter; a closure member mountable for sliding movement within the drainage tube between a first position such that said drainage opening is in fluid communication with the drainage outlet and a second position wherein the closure member blocks fluid communication between the drainage opening and the outlet port; and an actuator, operable from the proximal end of the catheter, to move the closure member between the first and second positions. The closure member can include a second tube, sliding within the drainage tube, or a slideable plug.

Abstract: Medical devices, methods and kits are described. An exemplary medical device comprises a catheter that has a catheter wall and defines a catheter lumen, a bend, and a coil disposed distal to the bend. The catheter defines one or more apertures that extend through the catheter wall and are in communication with the catheter lumen.

Abstract: A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

Abstract: The invention relates to a vacuum treatment array having at least one open-pored contact element, by way of which a negative pressure and/or suction can be generated in a body cavity, wherein the open-pored contact element is configured, at least in sections, in the manner of a tube, having an outer and/or inner boundary surface rotating around a tube axis, at least in part.

Abstract: A system and method for catheter placement using ECG is provided. In certain embodiments, the system and method can generate a patient specific window for tracking a characteristic of an ECG waveform, such as the amplitude of a P-wave. The patient specific window can be utilized in a system and method for assisting in the placement of a catheter within a patient.

Abstract: Steerable medical delivery devices that have a steerable portion and an external controller. The steerable portion has a first tubular member comprising a flexible polymeric tubular member that comprises a wall of solid material along the steerable portion, the first tubular member configured to preferentially bend, and a second tubular member, wherein one of the first and second tubular members is disposed within the other, wherein the first and second tubular members are permanently axially fixed relative to one another at a fixation location distal to the steerable portion.

Abstract: An endovascular guide catheter includes a guide tube and a handle. The flexible guide tube has a distal end portion configured to deflect via actuation of a pull wire. The handle is coupled to the guide tube and comprises a steering assembly configured to actuate the pull wire to deflect the distal end portion of the guide tube. The steering assembly can comprise a stationary rack, a gear, a reel, and a slider. The gear engages the rack and the reel is coupled to and configured to rotate with the gear. The pull wire is coupled to the reel such that rotation of the reel causes the pull wire to wind or unwind around the reel. The slider is adapted for translation relative to the rack. Translation of the slider translates the reel relative to the rack and rotation of the gear along the rack rotates the reel.

Abstract: The present invention relates to a steerable sheath tube (100) including a tube body (110), a traction mechanism (120) and a fixing and connecting mechanism (130). The traction mechanism (120) includes an anchor ring (121) and a traction wire (122). The anchor ring (121) is coaxially embedded in a distal elastic segment (111) of the tube body (110). The traction wire (122) is arranged in a side wall of the tube body (110), and extends along the axial direction of the tube body (110). The traction wire (122) includes a first segment and a second segment connected to each other, wherein the first segment is connected to the fixing and connecting mechanism (130) near a proximal end of the tube body (110), and the second segment hooks the anchor ring (121).

Abstract: An IV stabilizing device (1) which may be readily attached to or detached from a patient without the use of adhesives by providing a cuff (2) that fits around a patient's arm or other appendage. A securing aperture (11) is located on a body (3) of the cuff (2) through which an IV (8) is inserted under a portion of the cuff thereby allowing the cuff to hold the IV in place on the patient's appendage so it does not move. A window (7) is located above the securing aperture with a flap cover (9). The flap cover and window provide access to the IV.