Abstract: Procedures to achieve full subtotal, subcutaneous and suprafascial exeresis of fatty tissue between the skin and the musculature in lipedema and secondary lymphedema patients are provided. The procedures improve the patient's lymphological situation, such that no further manual lymphatic drainage or compression garments are required.

Abstract: A device for separation and collection of tissue from an effluent stream of tissue and carrier fluid generated in a medical procedure comprises a housing (600) having an upper wall (601a), a lower wall (602a), a circumferential wall (612) extending between the upper wall and lower wall, an inlet aperture 606a for receiving the effluent stream and an outlet aperture (607a) for discharge of filtered fluid. The housing encloses a filter member (603a) positioned between said upper wall and said lower wall and comprising at least one filter receptacle (615), the upper wall comprising a viewing window (604) for viewing tissue collected in the filter member. The inlet aperture is located beneath the filter member, and the device comprises a fluid pathway (628) for delivering effluent stream received through the inlet aperture into a said filter receptacle from above the filter member. The device can be compact whilst nonetheless allowing visualisation of collected tissue.

Abstract: In one example embodiment, a reduced pressure treatment system includes a housing defining a regulated chamber and a charging chamber in fluid communication with the regulated chamber. The charging chamber is configured to be supplied with a reduced pressure, and the regulated chamber is configured to regulate the reduced pressure to a desired reduced pressure and provide the desired reduced pressure to a treatment site. A housing extension adjacent to the charging chamber encloses a feedback module that includes a pressure sensor in fluid communication with the charging chamber. The feedback module monitors the reduced pressure within the charging chamber and generates at least one of an audible warning and a visual warning based on the reduced pressure within the charging chamber.

Abstract: A method and system for controlling inflammatory response at an internal tissue site of a patient utilizes a reduced-pressure treatment device. Controlling the inflammatory response may be accomplished in a number of ways that involve treating the inflammatory milieu. Treating the inflammatory milieu may include removing or moderating pro-inflammatory stimuli, e.g., fluids, enhancing perfusion of the tissue at or near the internal tissue site, or providing reduced-pressure therapy. The reduced-pressure treatment device is placed at or near the internal tissue site and is fluidly coupled to an external reduced-pressure source. The reduced-pressure treatment device provides reduced pressure proximate the tissue site and treats the inflammatory milieu. The reduced-pressure treatment device for controlling inflammatory response may be a minimally-invasive treatment device.

Abstract: Systems and methods for pumping milk from a breast responsive to a controller, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container under positive pressure.

Abstract: An implantable blood pump including a housing having an inlet cannula, a rotor disposed within the housing, the rotor in fluid communication with the inlet cannula, a stator disposed within the housing, the stator configured to rotate the rotor when a current is applied to the stator, and at least one ultraviolet light emitter disposed within the housing.

Abstract: A method of operating an implantable blood pump implanted within a heart of a patient comprising measuring at least one from the group consisting of a current drawn by the implantable blood pump and a blood flow from the implantable blood pump during operation; correlating the at least one from the group consisting the current and the blood flow to a systolic arterial pressure and a diastolic arterial pressure; and adjusting a speed of an impeller of the implantable blood pump relative to a predetermined speed to correspond to an increase the at least one from the group consisting the current during a systolic phase of a cardiac cycle and a decrease in the at least one from the group consisting the current and the blood flow during a diastolic phase of the cardiac cycle.

Abstract: A medical devices and methods related thereto are disclosed. In an embodiment, the medical device including a pump configured to be inserted within an atrium of a heart, said pump comprising an inlet and an outlet. In addition, the pump includes a flexible outflow conduit coupled to the outlet and configured to carry blood. The outflow conduit includes a radially inner surface defining a throughbore, and a radially outer surface. Further, the pump comprises a driveline configured to conduct control and power signals between the pump and an external device. The driveline extends through the outflow conduit between the radially inner surface and the radially outer surface.

Abstract: An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.

Abstract: This extracorporeal circulation cassette is provided with: a blood circuit (10) comprising a flexible tube and having a blood tube access portion set in a predetermined position in a device; a dialysate circuit (12) comprising a flexible tube and having a dialysate tube access portion set in a predetermined position in the device; a first panel (4) and a second panel (6) that are rigid and that integrate the blood circuit (10) and the dialysate circuit (12) while sandwiching the blood circuit (10) and the dialysate circuit (12) from both sides; and a window portion formed in a part of at least one of the first panel (4) and the second panel (6), disposed in a predetermined position in the device. The blood tube access portion and the dialysate tube access portion are positioned in the window portion.

Abstract: The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.

Abstract: An adsorbing material for multiple pathogenic factors of sepsis as well as a preparation method and an application thereof are provided. The adsorbing material is formed by coupling a carrier with good mechanical performance and blood compatibility and a ligand with the capacity to adsorb multiple pathogen-associated molecular patterns, and is capable of effectively adsorbing bacterial endotoxin, bacterial genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan from fluids such as blood and the like, and in particular has application value in blood purification for treatment of sepsis.

Abstract: Methods, systems, and devices are disclosed, embodiments of which provide single pass dialysis to remove water and uremic toxins is performed simultaneously with the albumin dialysis therapy by passing the albumin solution through a dialysis filter which dialyses it before the solution is returned to the cycler. In embodiments, the single pass dialysis stage is upstream of the albumin filtering stage.

Abstract: The present disclosure describes a system and method for microfluidic separation. More particularly, the disclosure describes a system and method for the purification of a fluid by the removal of undesired particles. The device includes microfluidic separation channels that include multiple outlets. The device also includes isolation slots positioned between each of the microfluidic separation channels. The device's base includes multiple acoustic transducers which in some implementations are configured to protrude into the isolation slots. The acoustic transducers are configured to generate aggregation axes within the separation channels, which are used to separate out undesired particles.

Abstract: A drainage catheter with retractable internal drains for fluid drainage and irrigation. The drainage catheter with retractable internal drains generally includes a primary catheter for insertion within a subject, a lumen within the primary catheter for conducting fluid flow between a source of fluid drainage or irrigation and the subject, and a plurality of selectively retractable and deployable drains in fluid communication with the lumen. Retraction and deployment of the drains within a subject is accomplished remotely via a specially shaped stylet and common drain connector within the primary catheter. The plurality of drains are enclosed within the primary catheter in the retracted state and extend radially outwardly from the primary catheter in the deployed state. In the retracted state, insertion and location of the primary catheter in a subject are facilitated. In the deployed state, expanded and improved drainage and irrigation area and a plurality of fluid flow paths and locations are provided.

Abstract: An assembly for storing both new and used pen needles of an injection apparatus, comprising a plurality of storage units each configured to store a pen needle having a needle fixed to a hub, the plurality of storage units being hingedly connected, and each including a storage end, and a dispensing end having an anti-rotation structure, wherein the anti-rotation structure working in conjunction with the hub of the pen needle to prevent rotation of the pen needle when the pen needle is in a dispensing position.

Abstract: This invention relates to a means of safely preforming intravenous infusion on a patient while the patient utilizes a tricycle, bicycle, bicycle with training wheels, toy motor vehicle, stroller, pram, push toy, or related device.

Abstract: An insulin infusion set (IIS) device with one or more features designed to achieve longevity in a patients continuous subcutaneous insulin infusion (CSII) site viability. One exemplary feature is an adsorbent material configured to adsorb phenolic excipients (e.g., m-cresol or other preservatives) from the insulin formulation. The adsorbent material may be positioned along a fluid pathway specifically designed to increase and/or extend exposure between the insulin formulation and the adsorbent material. Another exemplary feature is a medicament configured to reduce the patients inflammation or slow the progression of the patients inflammatory response. Yet another exemplary feature is a diffusive catheter configured to deliver the insulin formulation in a diffuse manner.

Abstract: Disclosed are hypodermic needle devices with a dose dispensing mechanism and methods of using those hypodermic needle devices. The dose dispensing mechanism, which may be an electronically-controlled pump, may be used to measure out a specific dosage amount of a drug while compensating for environmental factors, such as temperature and pressure. This allows the device to be used by patients for self-administration since a specific dosage amount of the drug may be precisely delivered regardless of the environmental conditions at the time of delivery. The specific dosage amount may be set using the device or remotely, and a fingerprint sensor may be used to prevent injecting the drug into the wrong patient.

Abstract: Optimized bio-synchronous drug delivery begins with establishing a bio-synchronous treatment protocol that incorporates individual temporal and innate biological characteristics into a pharmacological treatment plan. The bio-synchronous treatment protocol is thereafter initiated using bioactive agent delivery device. Bio-synchronous drug delivery includes continual collection of patient data such as physical, psychological, temporal and environmental characteristics. This data is analyzed so to not only determine an initial treatment protocol but to also determining whether modification to the ongoing bio-synchronous treatment protocol is required. And, responsive to determining a modification is required the system modifies the bio-synchronous treatment protocol and use of delivery device. These modifications and treatment protocols can include reactive and proactive psychological support supplied to the patient in a variety of formats.

Abstract: Some embodiments of an infusion pump assembly may be equipped with one or more components to facilitate wireless operation of an infusion pump via a user-operated mobile device. In some embodiments, the mobile device and/or the infusion pump may prompt the user to confirm acceptance of a wirelessly communicated command to prevent an operation by the infusion pump (e.g., a dispensation of medicine) that is not desired by the user.

Abstract: Safety features are applied to an integrated insulin delivery system to enhance safety by controlling medication delivery including the automatic resumption of basal rate after a particular event, such as termination of a bolus, expiration of a time period, delayed resumption after the bolus has terminated, IOB comparison, and others. Other safety features include overriding a delivery control that may result in hypoglycemia, and terminating an extended bolus or temporary basal rate in view of a glucose signal indicating imminent carbohydrate deficiency. In another feature, an automatic resumption of a basal delivery rate is programmed into the delivery device to avoid the possibility of complete loss of delivery of insulin in the event that communication with the delivery device is disrupted.

Abstract: The present invention discloses a multifunctional assistant treatment robot, comprising a top plate, wherein the bottom of the top plate is provided with a first mounting groove into which a first pushrod motor is fixedly mounted with its output shaft being connected with a puncture needle, and the bottom of the top plate is welded with a second vertical plate, the bottom of the top plate is further provided with an inclined groove, an inclined plate is slidably connected onto a top inner wall of the inclined groove, the first pushrod motor is located between the second vertical plate and the inclined plate, a treatment bed is provided below the first mounting groove, and a foam plate is placed at the top of the treatment bed and is located below the puncture needle.

Abstract: An auto-injection device for delivery of a fluid medicament is provided. The device includes an ampoule having a fluid medicament contained between first and second stoppers; a first sleeve movable along the longitudinal direction relative to the ampoule; a second sleeve at least partially surrounding the ampoule and movable along the longitudinal direction relative to the ampoule; and a needle. The first sleeve is movable along the longitudinal direction relative to the second sleeve and the ampoule between a first position and a second position. The needle is unexposed in the first position but exposed along the longitudinal direction in the second position. The second sleeve is also movable along the longitudinal direction relative to the ampoule between a first position and a second position. The needle is fluidly isolated from the medicament in the first position and is in fluid communication with the medicament in the second position.

Abstract: A syringe barrel includes: a hollow body portion that is configured such that a gasket is slidably insertable therein. The syringe barrel is made of a resin that has a total light transmittance of 80% or more. A scale is disposed at an inner circumferential surface or an outer circumferential surface of the body portion, the scale being visible from an outside of the syringe barrel and being configured to indicate a liquid amount. The scale is formed by (i) a stepped structure having a step height in a range of 0.001 to 0.15 mm in a radial direction, and/or (ii) an embossment.

Abstract: A syringe body for a prefilled syringe includes: a hollow body portion; a proximal-end opening portion provided at a proximal end portion of the body portion; and a distal-end nozzle provided at a distal end portion of the body portion. The body portion is made of a cyclic olefin polymer or a cyclic olefin copolymer. The body portion has a thick body portion accounting for 80% or more of the body portion along an axial direction. A wall thickness of the thick body portion is 2.23 to 2.40 mm.

Abstract: A cold slurry syringe with enhanced features is provided for delivering a cold slurry into the human body. The syringe includes a syringe body for holding a volume of cold slurry, a plunger that slides within the syringe body for ejecting the cold slurry, and a tapered syringe head for delivering an even flow of cold slurry. An agitator can be added to keep the cold slurry from agglomerating and clogging the syringe. Insulation added around the syringe can keep the cold slurry from melting too quickly. A ball screw drive can be added to provide a smooth and consistent application of pressure as the cold slurry is delivered. The cold slurry flow can be enhanced by adding a streamline flow feature that reduces the occurrence of eddies or swirls inside the syringe. This feature can also help maintain the composition and consistency of the cold slurry.

Abstract: A syringe apparatus is provided for stirring and delivering single or multi-component compositions. The syringe apparatus comprises a syringe barrel, a plunger, a stirring paddle, and a connecting member. The plunger partially disposed within the syringe barrel is movable along an axial direction of the syringe barrel. The stirring paddle disposed within the syringe barrel has one end passing through the plunger and slidably disposed within the plunger. The syringe apparatus of the disclosure can stir the components and deliver the mixture safely for maintaining a good hygiene condition during the therapeutic process.

Abstract: Techniques are disclosed for using electrical impedance measurements to help determine whether a hypodermic needle has been inserted into the skin, thereby increasing the accuracy of information provided to the stakeholders and/or enabling other functionality based on the determination. This information can be used and/or combined with other information to help determine whether to administer the drug and/or whether the drug has been administered properly.

Abstract: An anti-back mechanism for a drug delivery device according to the present application includes a retaining groove, a position retaining protrusion and a clamping groove. The retaining groove is provided on a push rod. The position retaining protrusion is provided in the drug delivery device. The clamping groove has an accommodation cavity into which the position retaining protrusion is inserted. The position retaining protrusion is provided on a ring having a notch and may be clamped with respect to the push rod when the position retaining protrusion is squeezed. When the position retaining protrusion is subjected to a reverse thrust from a cartridge holder of the drug delivery device, the position retaining protrusion may move in a direction opposite to an injection direction, be inserted into the clamping groove to be clamped, and be hooked to the retaining groove to be locked.

Abstract: Methods, systems, computer-readable media, and apparatuses for facilitating administering of medicine are disclosed.

Abstract: Methods, systems, computer-readable media, and apparatuses for facilitating administering of medicine are disclosed.

Abstract: A drive-control system for an injection device for delivering set-table doses of a pharmaceutical substance contained in a cartridge (3), the system comprising a tubular housing body (2) having a longitudinal axis (A-A), a proximal end (2a) and a distal end (2b) connectable to the cartridge enclosure (3), the system further comprising a helical spring (7) contained in the housing body and a piston rod (6) moveable towards said distal end (2b) and blocked in translation towards the proximal end (2a).

Abstract: The present disclosure is directed to a drive sleeve with a hollow body having a ring of crown teeth with a first outer diameter forming a clutch interface at a first end and a thread extending on an outer surface of the body. The thread has a major diameter and a minor diameter, wherein the ring of crown teeth has at least two cavities. The at least two cavities extend on the outer surface of the body from the first end to the thread and defining a second outer diameter which is smaller than the major diameter of the thread.

Abstract: Disclosed herein are techniques for drug delivery measurement. A medicine delivery device includes a cartridge for storing a medicine, a needle assembly coupled to a bottom of the cartridge, a piston located in the cartridge for pushing the medicine to dispense the medicine from the cartridge through the needle assembly, and a sensor configured to measure a distance between the piston and the bottom of the cartridge. The sensor includes a triangulation-based distance measurement unit, a resonant frequency-based distance measurement unit, a time-of-flight-based distance measurement unit, or a frequency-modulated continuous-wave time-of-flight-based distance measurement unit.

Abstract: Methods, systems, computer-readable media, and apparatuses for facilitating administering of medicine are disclosed.

Abstract: Disclosed herein are techniques for drug delivery measurement. A medicine delivery device includes a cartridge for storing a medicine, a needle assembly coupled to a bottom of the cartridge, a piston located in the cartridge for pushing the medicine to dispense the medicine from the cartridge through the needle assembly, and a sensor configured to measure a distance between the piston and the bottom of the cartridge. The sensor includes a triangulation-based distance measurement unit, a resonant frequency-based distance measurement unit, a time-of-flight-based distance measurement unit, or a frequency-modulated continuous-wave time-of-flight-based distance measurement unit.

Abstract: An implant syringe with a syringe needle holder, having an axially adjoining preparation receptacle; an outer sleeve with a radially projecting front gripping section, connected together for common axial movement; an inner sleeve, on which the outer sleeve is slidably located and in which the syringe needle is movable with the preparation receptacle. The inner sleeve has axial slots, through which webs engage, which connect the outer sleeve to the syringe needle holder, further including a rod-shaped piston, fastened to a rear gripping section partially surrounded by a rear sleeve, movably engaged in the inner sleeve. The rod-shaped piston is advanceable through the preparation receptacle in the syringe needle so that a distance remains between the tip of the syringe needle and the head end of the piston approximately equal to the length of the preparation to be delivered.

Abstract: Techniques are disclosed for providing a flowmeter in a hypodermic needle device to measure the flow of a drug from a reservoir located within a hypodermic needle device through a needle assembly. In some embodiments a valve may be additionally provided to control the flow of the drug from a reservoir located within a hypodermic needle device through a needle assembly. Such functionality can help ensure the proper dosage is dispensed and/or determine when the drug is improperly dispensed.

Abstract: An air removal device for an intravenous fluid system includes a housing with an inlet for fluid communication with a fluid source, a fluid outlet for fluid communication with a blood vessel of a patient, and an air outlet. The air removal device further includes a disrupting element disposed within the housing in a flow path between the inlet and the fluid outlet, and an air chamber in fluid communication with the air outlet. The disrupting element includes a protrusion extending across the flow path. The flow path includes a first cross-sectional flow area at the inlet, and a second cross-sectional flow area at the protrusion. The second cross-sectional flow area is smaller than the first cross-sectional flow area.

Abstract: A method, including ejecting irrigation fluid from a distal end of a probe so as to irrigate tissue, and receiving, over a period of time, initial signals indicative of respective temperatures of the distal end, from a temperature sensor in the distal end. The method also includes formulating from the initial signals a temperature range between upper and lower temperature thresholds and, when a further signal from the temperature sensor, received subsequent to the period of time, is indicative of a further temperature above the upper temperature threshold, raising an alarm that a bubble is present in the irrigation fluid.

Abstract: An electronic vapor device including: a device processor operable for controlling the electronic vapor device; a container configured to store a vaporizable material; a vaporizing component, wherein the vaporizing component is in fluid communication with the container for receiving a selected amount of vaporizable material therefrom; at least one sensing component, wherein the at least one sensing component is configured to detect a plurality of status data associated with the vaporizable material; and wherein the device processor is further operable to: receive at least a portion of the detected status data from the at least one sensing component; determine at least one vaporizing configuration for vaporizing at least a portion of the vaporizable material received in the vaporizing component, and generate at least one vaporizing control signal for controlling at least one operational parameter of the electronic vapor device in accordance with the at least vaporizing configuration.

Abstract: A mesh nebulizer includes a main body including a recess with a shape that is open upward. The main body includes a vibration portion with a vibration surface, and a liquid supply portion that supplies the liquid onto the vibration surface. The mesh nebulizer also includes a cap that openably and closeably covers the upper portion of the main body, and a replacement member that is separate from the main body and the cap and detachably mounted in the recess of the main body in advance when the nebulizer is to be used. The replacement member includes a film mesh portion, a bottom plate portion, and a side wall portion. When the cap is closed with respect to the main body, the protrusion portion of the cap presses the bottom plate portion of the replacement member toward the bottom surface of the recess, thus positioning the replacement member in the vertical axis direction of the main body.

Abstract: Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery.

Abstract: Nebulizer devices and methods are provided to facilitate a specific and controlled dosage of an atomized liquid therapy or medicine into the respiratory system of a user. The discrete nebulizer device comprises, in part, an airflow sensor connected to a controller such that inhaling through a mouthpiece ultimately activates the atomizer element to convert a liquid into an atomized liquid to maximize efficient delivery of the atomized liquid to the respiratory system of the user during inhalation. Multiple doses may be administered during sequential inhalations and exhalations without the need to remove the device from the air way opening of the user. In some embodiments, the nebulizer is programmable, hand-held, and/or disposable, for example.

Abstract: A system, accompanying apparatuses and methods relating to an oral or nasal enhanced nano-mist delivery and lung cleansing system having for an object to provide a safe system and method of delivering heated, moist, flavored air into the lower TB and alveolar regions of lungs.

Abstract: Systems are disclosed for facilitating intranasal treatment of a patient's sphenopalatine/pterygopalatine recess. Likewise the instant system is effective for addressing acute pain conditions, and is refined enough to be performed by physician's assistants, nurses, and other well-trained practitioners. Apparatus involved includes a sheath hub, a catheter hub, an arresting element, and an engagement element in embodiments. Engagement between the arresting element and the engagement element prevents rotation of the sheath hub with respect to the catheter hub.

Abstract: A nasal clip and/or dilator which is U-shaped having protruding wider spherical/spheroid holders at each end of the U is designed to be placed such that each spherical holder is in a nostril. The U-shaped clip can press against the columella and each holder against the septum. Inside each holder is a scented piece, such as a plastic ball or cylinder with aromatic compounds there-in which exit from the surface of the respective scented piece. To facilitate the scent escaping from the scented piece and into the nose, each holder has portals such as around the circumference thereof and/or on opposite sides thereof, transverse to the “U” of the holder.

Abstract: The present invention connects to tubing through which gas flows to a patient. An alert notifies monitoring personnel that oxygen flow to the patient has been interrupted, because the tubing has been disconnected. The invention comprises an adapter that is connected to a gas or oxygen source and a nipple over which the tubing fits and through which oxygen flows to the patient. When the tubing becomes disconnected from the nipple, the oxygen flow actuates an alert. The invention includes a fixed arm, a swing arm, and a spring. When the tubing becomes disconnected, the swing arm pivots and causes a switch actuator to engage a switch that sends a signal to an alert. The alert can be audible or visual.

Abstract: A ventilator system for providing respiratory support in cases of acute respiratory failure or severe trauma is described. The ventilator system comprises a ventilator and a tubing system. The system is characterized in that the ventilator comprises a continuous bleed valve configured to be open to air flow from the blower at all times when the blower is operating during both inspiration and expiration; thereby providing a minimal amount of pressure within a patient's lungs at the end of each exhalation positive end expiratory pressure (PEEP). In an embodiment of the invention the system comprises a manifold block configured to hold the main operating elements of ventilator.