Patents Issued in March 7, 2019
  • Publication number: 20190070217
    Abstract: The invention relates to small granules comprising cholestyramine. The granules have a high cholestyramine content and are stable enough to be coated with one or more coating layers. The invention also relates to a multiparticulate drug delivery system comprising such granules. The invention further relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine granules that are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption and bile acid diarrhoea.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 7, 2019
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Kurt Lövgren
  • Publication number: 20190070218
    Abstract: The present invention provides methods for treating an inflammatory brain disease and for treating a traumatic brain injury in a human having an inflammatory component applying transdermal pharmaceutical compositions comprising chromium, magnesium, and thiamine as active ingredient compounds that act as neuroprotective iron chelators and brain glucose-uptake enhancement that are suitable for the treatment of traumatic brain injury. The invention further relates to methods of delivering the pharmaceutical compositions that target the brain and/or central nervous system certain novel iron chelators of the type described in the specification.
    Type: Application
    Filed: September 5, 2017
    Publication date: March 7, 2019
    Inventor: KENNETH O. RUSSELL
  • Publication number: 20190070219
    Abstract: A homeopath nasal spray, swab or gel solution is provided. The composition includes a 1× to 6× (3C) dilution of argentum nitricum, 10× to 30× (5C to 15C), and any other higher or LM potencies, dilution of at least one of an additional argentum compound selected from the group consisting of argentum cyanatum, argentum iodatum, argentum metallicum, argentum muriaticum, argentum oxydatum and argentum phosphoricum; and, 10× to 30× (5C to 15C), and any other higher or LM potencies, dilution of at least one homeopathic compound for reducing various health conditions.
    Type: Application
    Filed: September 5, 2018
    Publication date: March 7, 2019
    Inventor: Frank J. King
  • Publication number: 20190070220
    Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.
    Type: Application
    Filed: July 7, 2016
    Publication date: March 7, 2019
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: David Gottlieb, Leighton Clancy
  • Publication number: 20190070221
    Abstract: The present disclosure includes compositions, methods, and uses for a subset of T cells, SP T (TSP) cells, which display a quiescent (G0) phenotype. Aspects of the disclosure include methods for obtaining and mobilizing TSP cells in a subject. Other aspects include methods of adoptive cell transfer in a subject utilizing TSP cells.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 7, 2019
    Inventors: Madhav DHODAPKAR, Venkata Naga Chandrasekhar BODDUPALLI
  • Publication number: 20190070222
    Abstract: The present invention provides improved and/or shortened methods for expanding TILs and producing therapeutic populations of TILs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TILs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TILs find use in therapeutic treatment regimens.
    Type: Application
    Filed: November 15, 2018
    Publication date: March 7, 2019
    Inventors: Seth Wardell, James Bender, Michael T. Lotze
  • Publication number: 20190070223
    Abstract: The present invention relates to a selection method of a highly active stem cell for treatment of cerebrovascular diseases, comprising a step of measuring a level of a neurotrophic factor, and a highly active stem cell selected thereby. According to the present invention, BDNF secreted by mesenchymal stem cells mediate inhibitory effects on cell death, inflammation, astrogliosis, and posthemorrhagic hydrocephalus and plays a very important role in improving myelination after intraventricular hemorrhage. Hence, the method according to the present invention can be usefully applied to the treatment of various cerebrovascular diseases including intraventricular hemorrhage in preterm infants.
    Type: Application
    Filed: March 30, 2017
    Publication date: March 7, 2019
    Applicant: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
    Inventors: Yun Sil CHANG, Won Soon PARK, So Yoon AHN, Dong Kyung SUNG
  • Publication number: 20190070224
    Abstract: A tissue repair material derived from fish skin and manufacturing method thereof is applied to provide the tissue repair material suitable for use as a patch, a cover, a carrier, a scaffold, an implant or a reagent in various tissues. The tissue repair material has collagens to improve the wounded tissue repair, and has particular characters for desired tissue repair application. Furthermore, so far the factors of the terrestrial animal transmitted disease (caused by virus) do not survive on the tissue repair material derived from fish skin.
    Type: Application
    Filed: November 2, 2018
    Publication date: March 7, 2019
    Inventors: Horng-Ji Lai, Min-Chang Huang, Jui-Min Ho, Yun-Ting Hsu, Yu-Chi Lin, Ta-Wei Su, Kuan-Hao Huang, Yu-Wei Chang
  • Publication number: 20190070225
    Abstract: The present disclosure relates to methods of treating at least one symptom of a mental disorder or disease of the central nervous system in a subject by modulating the amount of GABA produced in the subject's gut. The present disclosure also relates to methods of culturing the bacterial strain new bacterial strains. Also disclosed are methods of identifying bacterial strains capable of producing GABA, and engineering strains to produce GABA.
    Type: Application
    Filed: March 13, 2017
    Publication date: March 7, 2019
    Inventors: Philip STRANDWITZ, Kim LEWIS
  • Publication number: 20190070226
    Abstract: Embodiments of the disclosure concern methods and compositions related to manipulation of the microbiome in an individual having at least one social behavior deficit. In particular embodiments, an individual has at least one social behavior deficit and was born from a mother who during pregnancy was obese, overweight, or on a high-fat diet during pregnancy or carries mutations associated with neurodevelopmental disorders. In specific embodiments, the individual having at least one social behavior deficit is provided an effective amount of Lactobacillus reuteri for the improvement of at least one symptom of a social behavior deficit.
    Type: Application
    Filed: April 15, 2017
    Publication date: March 7, 2019
    Inventors: Mauro Costa-Mattioli, Shelly Alexandra Buffington
  • Publication number: 20190070227
    Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
    Type: Application
    Filed: October 12, 2018
    Publication date: March 7, 2019
    Inventors: Colleen CUTCLIFFE, John S. EID, James H. BULLARD, Marcus F. SCHICKLBERGER
  • Publication number: 20190070228
    Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
    Type: Application
    Filed: October 12, 2018
    Publication date: March 7, 2019
    Inventors: Colleen CUTCLIFFE, John S. EID, James H. BULLARD, Marcus F. SCHICKLBERGER
  • Publication number: 20190070229
    Abstract: A composition comprising combination of salt, sugar and lactic acid bacteria as an active ingredient to treat vaginosis. The composition showed potent antibacterial activity through various experiments, for example, (1) the indirect inhibitory activity test from the growth of vaginosis causing bacteria by determining the change of pH and lactic acid level; (2) the direct inhibitory activity test from the growth of vaginosis causing bacteria by determining the susceptibility of test sample; (3) brief clinical tests, and finally confirmed that the combination showed potent antibacterial activity in the test. Accordingly, the combination may be useful to alleviate and treat vaginosis in the form of a pharmaceutical composition, health functional food, food additive, topical composition, and detergent composition.
    Type: Application
    Filed: April 26, 2017
    Publication date: March 7, 2019
    Inventors: Won Seog CHOI, Moo Hyung LEE
  • Publication number: 20190070230
    Abstract: An object of the present invention is to provide a lactic acid bacterium that inhibits secondary fermentation of silage and proves useful in the preparation of preferable silage. Another object of the present invention is to provide a method for manufacturing silage whose secondary fermentation is inhibited. As a means for achieving the objects, a Lactobacillus diolivorans having anti-yeast action is provided as a lactic acid bacterium for preparing silage.
    Type: Application
    Filed: March 8, 2017
    Publication date: March 7, 2019
    Inventors: Mitsuru HONMA, Toru KITAMURA
  • Publication number: 20190070231
    Abstract: The present invention relates to a new cocktail of bacteriophages with specific lytic activity against Salmonella enteritidis, Salmonella typhimurium and Salmonella paratyphi B., for reducing, eliminating and/or preventing them in farm animals and animals from the poultry sector, such as poultry, hens and breeding hens, in addition to eggs. It may be administered as an additive in the feed, in water or by spray. Moreover, the cocktail may be used as a disinfectant in work areas of farms and abattoirs, and in processed foods, without affecting the organoleptic properties of the product.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 7, 2019
    Inventors: Martha Josefina VIVES FLOREZ, Ana Paula JIMENEZ SANCHEZ, Angela Victoria HOLGUIN MORENO
  • Publication number: 20190070232
    Abstract: Disclosed herein are novel methodologies for cloning prophage genome sequences that are identified from target organisms or DNA sequencing data and that contain mutations that decrease the function of prophage repressor proteins and for producing lytic phage particles with decreased prophage repressor protein function.
    Type: Application
    Filed: March 5, 2018
    Publication date: March 7, 2019
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Timothy Kuan-Ta LU, Robert James CITORIK
  • Publication number: 20190070233
    Abstract: The present invention provides methods for treating an individual having solid or lymphatic tumor comprising locally administering to the site of the tumor an oncolytic virus, and systemically administering an immunomodulator (including a combination of immunomodulators). The methods may further comprise local administration to the site of the tumor a second immunomodulator (including a combination of immunomodulators). Also provided are compositions and kits for the cancer therapy methods.
    Type: Application
    Filed: March 9, 2017
    Publication date: March 7, 2019
    Inventors: Alex Wah Hin YEUNG, Arthur KUAN
  • Publication number: 20190070234
    Abstract: A method for introducing a fermented product to poultry to reduce foodborne pathogens. The fermented product contains functional metabolites produced by Saccharomyces cerevisiae and is added at a particular ratio to the feed for the most effective results.
    Type: Application
    Filed: November 6, 2018
    Publication date: March 7, 2019
    Applicant: CAN TECHNOLOGIES, INC.
    Inventors: Donald McINTYRE, Michael MITCHELL
  • Publication number: 20190070235
    Abstract: A method for treating hepatitis B comprises administering a herbal extract to a subject in need thereof to suppress survival of hepatitis B virus. The herbal extract is manufactured by extracting a herbal composition by a 70-95% aqueous ethanol solution at 40-50° C. The herbal composition comprises 40 wt % of a fruit body sample of Antrodia cinnamomea, 40 wt % of a sample of Polygonatum sibiricum and 20 wt % of a sample of Glycyrrhiza uralensis.
    Type: Application
    Filed: October 12, 2017
    Publication date: March 7, 2019
    Inventors: Shorong-Shii Liou, I-Min Liu, Hung-Tsung Wu
  • Publication number: 20190070236
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, MORINDAE OFFICINALIS RADIX polysaccharide, POLYGONATI RHIZOMA polysaccharide, ANGELICAE SINENSIS RADIX oil and MYRISTICAE SEMEN oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, enhances body immune function, restores normal immune surveillance function, decreases VEGF and TGF-?1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Application
    Filed: August 8, 2018
    Publication date: March 7, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Yuanyuan WANG, Fangli MA, Renhuai CONG, Minghua HU, Chung Wah MA
  • Publication number: 20190070237
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising GANODERMA polysaccharide, GRIFOLA FRONDOSA polysaccharide, ANGELICAE SINENSIS RADIX oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Application
    Filed: August 9, 2018
    Publication date: March 7, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Minghua HU, Fangli MA, Yuanyuan WANG, Chung Wah MA, Renhuai CONG, Lingyun XIAO
  • Publication number: 20190070238
    Abstract: A human oral at least partly enteric formulation comprising one or more jojoba components, for controlling, stimulating or modulating functions for patients suffering from a degenerative disease, or for patients at risk from suffering from a degenerative disease, or for patients under therapeutic treatment of a degenerative disease.
    Type: Application
    Filed: November 2, 2018
    Publication date: March 7, 2019
    Inventors: Stefaan Raes, Herman Van Den Driessche
  • Publication number: 20190070239
    Abstract: An edible herbal formulation which raises the alkalinity of the human body in a short period of time is disclosed. The major ingredient in the formulation is Camptotheca. Additional ingredients that may be included are poria cocos, astragalus membranacaus, ostrea vivularis gould, prunella vulgaris, bombyx mori and phellodendron amurense Rupr. While the herbal formulation may be a mixture containing Camptotheca and all or some of the above ingredients, it is most preferred that the herbal formulation include the three ingredients of Camptotheca, poria cocos and astragalus membranacaus.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 7, 2019
    Applicant: Cheng Lab & Company, LLC
    Inventor: Yin Bong Cheng
  • Publication number: 20190070240
    Abstract: A gynostemma pentaphyllum-containing health care pharmaceutical composition for preventing hyperlipidemia, hypertension, hyperglycemia and gout is prepared by mixing raw materials of gynostemma pentaphyllum, folium eucommiae, folium mori, semen plantaginis, herba lophatheri, pueraria mirifica powder, pelargonium graveolens and sanguisorba minor, and the raw materials are in percentage by mass: 40-70% of gynostemma pentaphyllum, 5-20% of folium eucommiae, 5-20% of folium mori, 5-10% of semen plantaginis, 2-10% of herba lophatheri, 2-10% of pueraria mirifica powder, 2-8% of pelargonium graveolens and 2-8% of sanguisorba minor. The gynostemma pentaphyllum is prepared by mixing diploid gynostemma pentaphyllum leaves and tetraploid gynostemma pentaphyllum leaves according to a ratio.
    Type: Application
    Filed: November 8, 2018
    Publication date: March 7, 2019
    Inventors: Shaoke WANG, Theresa Y Y TSE, Zhao ZHANG
  • Publication number: 20190070241
    Abstract: The present invention relates to a composition for alleviating, preventing, or treating menopausal symptoms and/or osteoporosis. The composition of the present invention is rapidly effective in preventing or alleviating menopausal symptoms, and thus may be usefully used in conventional hormone replacement therapies (HRTs) used to prevent or alleviate menopausal symptoms. In addition, the composition of the present invention has no toxicity, can be used as food due to few side effects, and is safe, unlike conventional therapeutic agents for menopausal symptoms, and thus may be more effectively used as compared to conventional therapeutic agents for menopausal symptoms.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 7, 2019
    Applicant: LG Household & Health Care Ltd.
    Inventors: Youn Jung LEE, Ho Song CHO, Won Kyung LEE, Soon Ran SONG, Sang Hwa LEE
  • Publication number: 20190070242
    Abstract: Is herein described a nanoparticle ophthalmic composition comprising at least 0.1% of Perilla frutescens extract and at least 0.1% of hyaluronic acid or a salt thereof wherein the Perilla frutescens extract has a content of polyphenols of at least 2.5% by weight of the total weight of the extract and to the use of said ophthalmic composition in the treatment of ocular disorders or diseases such as tear dysfunction syndrome, dry eye, diabetic retinopathy and glaucoma, preferably in the treatment of tear dysfunction syndrome.
    Type: Application
    Filed: August 31, 2018
    Publication date: March 7, 2019
    Inventor: Giuseppe CAMPORA
  • Publication number: 20190070243
    Abstract: The objective of the present invention is to provide a safe muscle-enhancing agent by which a muscle mass and muscular strength can be effectively increased or maintained and by which a decrease of a muscle mass and muscular strength can be suppressed, a muscle-enhancing composition containing the muscle-enhancing agent, and a method for enhancing muscle by using the muscle-enhancing agent or muscle-enhancing composition. The muscle-enhancing agent according to the present invention is characterized in comprising an extract derived from lemon myrtle as an active ingredient.
    Type: Application
    Filed: October 6, 2016
    Publication date: March 7, 2019
    Applicant: Kaneka Corporation
    Inventors: Shinichi Honda, Shinichi Yokota, Mineko Ogura, Masanori Kato
  • Publication number: 20190070244
    Abstract: The present disclosure encompasses compositions prepared from Boysenberry. Also encompassed are methods of preparing these compositions and methods of using these compositions, in particular, for treating or preventing disorders of the respiratory system, including amongst others: inflammation, asthma, chronic obstructive pulmonary disease, reactive airway disease, airway fibrosis, and airway remodeling.
    Type: Application
    Filed: June 29, 2018
    Publication date: March 7, 2019
    Inventors: Odette M. Shaw, Roger D. Hurst
  • Publication number: 20190070245
    Abstract: The present document describes a nutriprotective diet comprising a nutriprotective amount of a sugar plant syrup, a sugar plant syrup extract, a sugar plant extract, or combinations thereof. The present document also describes a method of eliciting a nutriprotective effect in a subject, which comprises administering a nutriprotective amount of a nutriprotective diet according to the present invention. Also, the present document also describes a method of treating a subject with a disorder, by administering a nutriprotective amount of a nutriprotective diet according to the present invention. Also, the present document describes a process for the extraction of polyphenolic compounds from maple syrup using adsorbent materials, and the extracts obtained therefrom.
    Type: Application
    Filed: August 23, 2018
    Publication date: March 7, 2019
    Applicant: FÉDÉRATION DES PRODUCTEURS ACÉRICOLES DU QUÉBEC
    Inventors: Steeves POTVIN, Vincent BÉDARD, François BÉLAND, Geneviève BÉLAND, Keiko ABE
  • Publication number: 20190070246
    Abstract: The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising LYCII FRUCTUS polysaccharide, POLYGONATI RHIZOMA polysaccharide, CARYOPHYLLI FLOS oil and CINNAMOMI CORTEX oil. Experiments show that the traditional Chinese medicine composition has a scientific formulation, synergistic functions, without toxic and side effects, and not only has nutritional value but also inhibits the growth of tumor. Comparing with individual components, the composition significantly increases the percentages of CD4+ and CD8+ cells in lymphocytes of the tumor stroma, increases body immune function, recovers normal immune surveillance function, decreases the expression rate of VEGF and TGF-? 1 positive cells in tumor tissue, assists in treating tumor, increases antitumor effects of chemotherapy drugs, improves immune status of body, has the function of restoring normal immune surveillance, preventing and assisting in treating tumor.
    Type: Application
    Filed: August 8, 2018
    Publication date: March 7, 2019
    Applicant: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Fangli MA, Yuanyuan WANG, Minghua HU, Renhuai CONG, Lingyun XIAO, Chung Wah MA
  • Publication number: 20190070247
    Abstract: Compositions and Methods for the Treatment of Amyloid Deposit diseases, e.g., Hereditary cystatin C amyloid angiopathy and other neurodegenerative disorders, are disclosed.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 7, 2019
    Inventors: Hakon Hakonarson, Alvaro Gutierrez-Uzquiza, Michael March
  • Publication number: 20190070248
    Abstract: The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3?). These molecules compete with CD3? for binding to a CD3? binding domain. e.g. a CD3? binding domain of an antibody, and are capable of detecting antibodies against CD3?. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3? antibody purification and the detection of anti-CD3? antibodies in biological samples.
    Type: Application
    Filed: July 14, 2015
    Publication date: March 7, 2019
    Inventors: Ugur Sahin, Laura Marie Kring, Markus Fiedler, Matin Daneschdar, Hans-Ulrich Schmoldt, Ulf Reimer, Karsten Schnatbaum
  • Publication number: 20190070249
    Abstract: A microbial infection in an eye of a subject is treated or prevented by topically administering to the eye an effective amount of a macromolecule or a pharmaceutically acceptable salt thereof that includes a dendrimer of 1 to 8 generations with one or more sulfonic acid- or sulfonate-containing moieties attached to one or more surface groups of the outermost generation of the dendrimer. Compositions containing the macromolecule or salt are useful in these methods.
    Type: Application
    Filed: November 2, 2018
    Publication date: March 7, 2019
    Inventors: Jacinth Kincaid Fairley, Colin Paul Barrett, Jeremy Robert Arthur Paull
  • Publication number: 20190070250
    Abstract: The present invention relates, rider alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
    Type: Application
    Filed: September 19, 2018
    Publication date: March 7, 2019
    Inventor: Lakhmir S. CHAWLA
  • Publication number: 20190070251
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: April 28, 2017
    Publication date: March 7, 2019
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • Publication number: 20190070252
    Abstract: A composition is disclosed herein comprising from about 0.001% to about 0.
    Type: Application
    Filed: March 27, 2018
    Publication date: March 7, 2019
    Inventors: James N. Chang, Orest Olejnik, Bruce A. Firestone
  • Publication number: 20190070253
    Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified lectins. Also disclosed are methods for making and using the compositions.
    Type: Application
    Filed: November 6, 2018
    Publication date: March 7, 2019
    Applicants: The Population Council, Inc., The United States of America
    Inventors: Barry R. O'Keefe, Melissa Robbiani, José A. Fernández Romero
  • Publication number: 20190070254
    Abstract: The present disclosure relates to compositions comprising gymnemic acid, together with a form of zinc to block the unpleasant bitter taste of gymnemic acid as well as to extend the sweet taste blocking properties of gymnemic acid, resulting in palatable compositions for delivery to the oral cavity to block sweet taste receptors located therein. The present disclosure also relates to methods of reducing sugar consumption and reducing calorie intake via administration of such compositions to a subject.
    Type: Application
    Filed: April 5, 2018
    Publication date: March 7, 2019
    Inventors: Robert L. GOLDSTEIN, Grant DUBOIS, Arianne PERRY
  • Publication number: 20190070255
    Abstract: This invention pertains to the identification of antibody mediated epitope mimics and applications of the identification of said mimic peptides in the design of biotherapeutics and vaccines.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Inventors: Robert D. BREMEL, Jane HOMAN
  • Publication number: 20190070256
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Application
    Filed: October 4, 2018
    Publication date: March 7, 2019
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • Publication number: 20190070257
    Abstract: The present specification is directed to systems, apparatus and methods for prophylactically preventing, or for treating the progression of, Alzheimer's disease. The progression of, stabilizing, or improving Symptoms related to Alzheimer's Disease (AD) are treated by monitoring a pathophysiological change indicative of AD in a patient, based on the monitoring, determining if amyloid plaque is present in a perivascular space of the patient, optionally determining an extent of amyloid plaque in the perivascular space, and based on the presence of amyloid plaque in the perivascular space of the patient, determining a treatment protocol for the patient. The treatment protocol includes administering to the patient a high density lipoprotein composition derived from mixing a blood fraction with a lipid removing agent.
    Type: Application
    Filed: March 1, 2018
    Publication date: March 7, 2019
    Inventors: Hollis Bryan Brewer, Jr., Michael M. Matin
  • Publication number: 20190070258
    Abstract: The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the like by targeted administration to the oesphagus of a subject of Zn-?2-glycoproteins or a functional fragment thereof, alone or in combination with additional agents, such as ? adrenergin receptor agonists, ? adrenergin receptor antagonists, and/or glycemic control agents.
    Type: Application
    Filed: November 15, 2018
    Publication date: March 7, 2019
    Inventors: Michael Tisdale, Steven Russell
  • Publication number: 20190070259
    Abstract: The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53 amino acid sequences.
    Type: Application
    Filed: October 7, 2016
    Publication date: March 7, 2019
    Inventors: Joshua Schiffman, Avi Schroeder, Lisa Abegglen
  • Publication number: 20190070260
    Abstract: The present disclosure relates to suppression of cellular transformation and dysplasia by topical application of Lefty. In particular, the present disclosure provides compositions and methods for topically applying Lefty to treat and prevent cancers.
    Type: Application
    Filed: November 5, 2018
    Publication date: March 7, 2019
    Inventor: Charles E. Craft
  • Publication number: 20190070261
    Abstract: The subject invention provides materials and methods for modulating cellular glucose uptake. Specifically, in accordance with one embodiment of the subject invention, stem cell factor (SCF) can be used to stimulate cellular glucose uptake. The administration of SCF can also be used to promote Glucose Transporter 4 (GLUT4) expression. In accordance with the subject invention, SCF can be used to improve glucose homeostasis, including in the treatment of diabetes mellitus.
    Type: Application
    Filed: November 19, 2018
    Publication date: March 7, 2019
    Inventor: Ali NAYER
  • Publication number: 20190070262
    Abstract: The present invention provides compositions and methods comprising an activator of IL-18 activity for use in therapeutic and non-therapeutic applications. The activator provides IL-18 signaling activity even in the presence of an inhibitory molecule such as IL-18BP.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 7, 2019
    Inventors: Aaron Ring, Ting Zhou, Suzanne Fischer
  • Publication number: 20190070263
    Abstract: Embodiments relate to peptide antagonists of -family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (GvHD). Thus, inhibitors of -cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Traditional approaches to inhibiting yc-cytokine activity involve raising neutralizing antibodies against each individual -cytokine family member/? receptor subunit. However, success has been limited and often multiple -cytokine family members co-operate to cause the disease state. Combinatorial use of neutralizing antibodies raised against each factor is impractical and poses an increased risk of adverse immune reactions. The present embodiments overcome these shortcomings by utilizing peptide antagonists based on the consensus -subunit binding site to inhibit -cytokine activity.
    Type: Application
    Filed: October 6, 2016
    Publication date: March 7, 2019
    Inventor: Nazli Azimi
  • Publication number: 20190070264
    Abstract: An interleukin 15 (IL-15) protein complex is provided. The IL-15 protein complex includes soluble fusion proteins (I) and (II), wherein the fusion protein (I) is an IL-15 polypeptide or a functional fragment thereof, and the soluble fusion protein (II) is an IL-15R? polypeptide or a functional fragment thereof. The soluble fusion protein (I) has at least one amino acid residue mutated to a cysteine (Cys) residue, which pairs with a corresponding mutated Cys residue on the soluble fusion protein (II), or vice versa, to form one or more disulfide bonds. The IL-15 protein complex can be used for tumor therapy.
    Type: Application
    Filed: November 17, 2015
    Publication date: March 7, 2019
    Applicants: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Xiangdong QU, Xin YE, Qiyue HU, Dongbing CUI, Weikang TAO, Lianshan ZHANG, Piaoyang SUN
  • Publication number: 20190070265
    Abstract: The present invention refers to a pharmaceutical composition for use in the treatment of a neurodegenerative disease.
    Type: Application
    Filed: April 25, 2018
    Publication date: March 7, 2019
    Inventors: Sibylle Hess, Christian Hölscher
  • Publication number: 20190070266
    Abstract: The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.
    Type: Application
    Filed: March 3, 2017
    Publication date: March 7, 2019
    Inventor: Soeren Rasmussen