Abstract: A device for the fluid-conveying connection of at least one application probe. The device comprising at least two coaxially extending application line elements, with a supply tubing set, said tubing set comprising at least two parallel-extending supply line elements, in a grip element of a surgical instrument such as a cryosurgical instrument, such that, in a connected state, each supply line element is in fluid communication with at least one associated application line element. A fluid-diverting element is provided and arranged, or can be arranged, in the grip element in fluid communication with an application line connecting region for the connection of the application line elements and with a supply line connecting region for the connection of the supply line elements. At least two transfer line elements designed as an integral part of the fluid-diverting element are in fluid communication with the application line connecting region via the application line connecting region.

Abstract: A method and system of providing therapy to a patient's uterus. The method can include the steps of inserting a uterine ablation device into the uterus; expanding a distal anchor; inflating a proximal balloon to pull the distal anchor proximally and seat the distal anchor against the internal os of the uterus; inflating a central balloon to seal the cervix; delivering vapor from the uterine ablation device into the uterus; and condensing the vapor on tissue within the uterus. The can include a cervical collar adapted to place a distal portion of the device within the uterus when the cervical collar contacts an external os of the cervix.

Abstract: A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal having a frequency of at least 1 MHz prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.

Abstract: An instrument for use in a medical procedure that includes a proximal end, a distal end, a handle adjacent to the proximal end of the instrument, a flexible elongated neck extending distally from a distal end of the handle, a jaw power screw extending from a distal end of the neck, a pair of moveable jaws operatively connected to the jaw power screw, and a handle power screw assembly operatively connected to a proximal end of the flexible neck within the handle, wherein manipulation of the handle will control movement of the jaws.

Abstract: A device for extending, elongating, or repairing a previously created arteriovenous fistula between a first blood vessel and an adjacent second blood vessel includes a main body having a primary lumen and an articulating jaw member disposed at the distal end of the main body. The jaw member is configured with two elements to allow rotation of one element about a pivot point to grasp tissue while being rotated. The jaw member is also configured to allow thermal energy delivery to one or both elements of the jaw member that allow tissue welding and cutting. A second lumen located within one element of the jaw member is configured to allow advancement over a guidewire into the second vessel while the other element of the jaw member remains within the first blood vessel at the position where the arteriovenous fistula, or aperture, exists between the first and second blood vessel.

Abstract: A facet joint surgical tool for treating a facet joint synovial cyst includes rotatable members disposed side-by-side through a minimally invasive sheath and rotatable to reconfigure distal end portions between a facet joint penetration configuration with a tissue piercing tip and a facet joint retraction configuration. Facet joint synovial cysts located to an anterior side of the facet joint are treated by a posterior approach with access to the cyst through the facet joint retracted by the surgical tool. Facet joint synovial cysts located to a posterior side of the facet joint are treated by direct access from a posterior approach.

Abstract: Apparatus and methods are provided to concentrate energy delivery in non-superficial target tissue within a trigone region of a human bladder wall to modulate bladder function.

Abstract: A system for generating microwave energy includes a microwave generator that generates first and second microwave signals, a transmission line and a dual antenna microwave device. The transmission line transmits the first and second microwave signals to the microwave device. The microwave device includes a first antenna proximal a second antenna and a dual-sided choke positioned therebetween. The first antenna receives the first microwave signal from the transmission line between a first conductor and a second conductor and the second antenna receives the second microwave signal between the second conductor and a third conductor. The dual-sided choke includes a first and a second antenna choke circuit. The first antenna choke circuit limits the propagation of electromagnetic fields generated by the first antenna toward the second antenna and the second antenna choke circuit limits the propagation of electromagnetic fields generated by the second antenna toward the first antenna.

Abstract: An endovascular laser treatment device for causing closure of a blood vessel uses an optical fiber adapted to be inserted into a blood vessel. An inner sleeve is arranged around a distal portion of the optical fiber core such that both distal ends of the inner sleeve and the optical fiber core form an enlarged light emitting face. The enlarged emitting face provides substantially lower power density while providing the same amount of total energy during a treatment session. An outer sleeve arranged around the inner sleeve acts as a spacer to position the light emitting face away from an inner wall of the blood vessel. The enlarged light emitting face and the outer sleeve acting as a spacer reduces the possibility of thermal run-away and device damage, and reduce the possibility of vessel perforations, leading to less bruising, post-operative pain and other clinical complications.

Abstract: Direct anterior approach (DAA) with the patient lying supine has facilitated the use of intraoperative fluoroscopy and allows for standardized positioning of the patient. The method disclosed herein uses intraoperative fluoroscopy to measure acetabular component anteversion and more particularly, a method for measuring/calculating intraoperative cup (acetabular component) anteversion is provided based on the measured acetabular component abduction angle and a c-arm tilt angle (CaT).

Abstract: Disclosed are systems, devices, and methods for planning a procedure for treatment of lung tissue. An exemplary method includes generating a three-dimensional (3D) model of the luminal network, displaying the 3D model of the luminal network, selecting a target location in the tissue adjacent to the luminal network as displayed on the 3D model, identifying a point in the luminal network which is proximate to or at the target location, determining an access path between the target location and the identified point in the luminal network, calculating a risk of injury to intervening structures between the target location and the identified point in the luminal network, based on the determined access path, and displaying the access path and the calculated risk of injury for the access path on the 3D model.

Abstract: A robotic catheter procedure system for performing a procedure to treat a vascular lesion including a bedside system and a remote workstation is provided. The bedside system includes a first percutaneous device including an end section, the end section structured to allow the first percutaneous device to create a bore through the vascular lesion. The bedside system includes a second percutaneous device. The bedside system also includes a first actuating mechanism configured to engage and to impart movement to the first percutaneous device and a second actuating mechanism configured to engage and to impart movement to the second percutaneous device. The remote workstation includes a user interface and a control system operatively coupled to the user interface and to the bedside system.

Abstract: An apparatus (20) for performing endoscopic surgery on a patient (12) includes at least two concentric tube manipulators (150) adapted to carry devices (152, 154) for performing a surgical operation. A transmission (200) operates the concentric tube manipulators (150). An endoscope tube (106) has a proximal end portion fixed to the transmission (200). The concentric tube manipulators (150) extend from the transmission (200) through an inner lumen (102) of the endoscope tube (106) and are operable to extend from a distal end (104) of the endoscope tube.

Abstract: Embodiments of an actuated cannula seal are disclosed In some embodiments, a cannula seal includes a base portion that engages with a cannula; and a seal portion integrally formed with the base portion, the sealing portion capable of engaging with an instrument shaft, the sealing portion capable of being actuated by an actuator so that the sealing portion is continually in motion relative to the instrument shaft. The actuation of the sealing portion can be accomplished by rotation or vibration of the sealing portion relative to the instrument shaft.

Abstract: A highly articulated robotic probe comprises an outer sleeve and an inner core. The outer sleeve and inner core include a plurality of links. The links of the outer sleeve and inner core are configured to pivot relative to one another. Various characteristics of the links determine the overall pivot angle of the articulated probe. Each of the plurality of links may have one or more channels. The channels form a semi-continuous passage from link to link and are configured to receive an elongated member such as an inner core, tool or cable. One or more cables may be used to control the outer links of the outer sleeve and the inner links of the inner core. Various characteristics of the cables determine the overall performance of the articulated probe.

Abstract: Techniques for a surgical system are provided that allow controlling a force applied by an electromechanical surgical tool coupled to an electromechanical surgical arm. A force limiter can be associated with at least one of the surgical arm and the tool and is used to limit the force applied by jaws of the tool to tissue when the tissue is engaged therebetween or when the tissue is otherwise manipulated. The force can be limited to a maximum force value, which can be preselected, and it can be adjustable based on user input or automatically. Also are provided techniques for a surgical system that allow controlling a stiffness of an electromechanical passive arm coupled to a fixture and having an active arm mounted thereon. The stiffness is adjusted, either manually or automatically, by adjusting a friction at a joint of the arm based on an angle at the arm's joint.

Abstract: A hand-held medical device includes a housing, an electronic imager, and an optical system aligned with the electronic imager along an imaging axis of the device. An illumination system includes at least one light source for directing light towards a target of interest, as well as a display connected to the electronic imager and attached to the housing. A processor, disposed within the housing, is connected to the electronic imager, the illumination assembly and the display, and includes processing logic and data storage for storing a plurality of images.

Abstract: The invention relates to a processing system (200) that is arranged to cooperate with an optical-shape-sensing-enabled elongated interventional device (1020, 1120, 1220, 1320, 1420), such as a catheter comprising an optical fiber. A reconstructed shape data providing unit (130) provides reconstructed shape data for the interventional device (1020, 1120, 1220, 1320, 1420). A virtual marking provider unit (140) provides at least one virtual marking (1020A, 1020B, 1101, 1102, 1103, 1201, 1203, 1204, 1301, 1302, 1401) based on the reconstructed shape data, for example as overlay to a x-ray image. The present invention thus turns any OSS-enabled device into a calibrated device, suitable for all kinds of live 3D measurements.

Abstract: A marker device that aids in the subsequent identification of a particular area is equipped with an anchoring device that prevents migration once placed in the tissue of that particular area. The device may include a chemical agent or drug that adds a therapeutic function to the marker device.

Abstract: A single-use tissue marking system for use in marking a tissue sample includes a container and a first number of ink reservoirs at least partially defined by the container. Each reservoir contains ink of a different color. The system also includes a second number of applicators. Each applicator is configured to absorb a quantity of ink for application to the tissue sample. A cover is coupled to and cooperates with the container to fully enclose each of the first number of ink reservoirs.

Abstract: A method of making a superelastic medical device with a radiopaque marker includes threading a radiopaque marker having an elongated shape over a wire comprising a shape memory alloy. After the threading, the wire is secured in a predetermined configuration to a mandrel. While secured to the mandrel, the wire is heat set in an environment comprising an inert gas so as to impart a memory of the predetermined configuration to the wire and superelastic properties to the shape memory alloy. A superelastic medical device including the radiopaque marker is thus formed.

Abstract: Systems, devices and methods for advanced electrode management in neurological monitoring applications include receiving sockets configured to receive connectors having groups of electrodes. The physician is not required to manually map each electrode with its corresponding input channel. Electrodes are coupled to the corresponding input channels in groups through connectors having a unique identification (ID). The system is configured to read the unique ID of each connector and establish its identity. Based on the ID, the system configures itself to automatically correlate or associate each electrode with its corresponding input channel when the connectors are first inserted into the receiving sockets, and again if the connectors are removed and re-inserted into different positions in the receiving sockets, to insure the electrodes are always mapped to the same input channels.

Abstract: A system and method for supplying energy to an implanted medical device is disclosed. The system comprises an internal charger having a first coil, an external charged arranged to wirelessly transmit energy to supply the internal charger with energy, the external charger comprising a second coil, and a wireless feedback system arranged to transmit feedback information from the internal charger to the external charger. The feedback information is based on information obtained from at least one radio frequency identification (RFID) transmitter.

Abstract: In one embodiment, a dental bur includes a proximal shank, an intermediate cutting section, and a smooth, rounded distal tip. The cutting section includes (i) a frustum-shaped portion connected at its larger-diameter end to the shank and (ii) a curved portion that provides a transition between the smaller-diameter end of the frustum-shaped portion and the rounded tip, where the outer surfaces of the frustum-shaped portion and the curved portion are both sufficiently abrasive to remove bone tissue due to the presence of surface grit and/or flutes that provide bone-cutting edges. The dental bur reduces and flattens the bone tissue of the maxillary and mandibular bones for surgical dental implants without unwanted soft tissue damage.

Abstract: A wedge system for use in a dental restoration procedure for a posterior tooth. The wedge system includes a first wedge including a body, a first arm extending from the body, a second arm extending from the body, and a gap formed between the first arm and the second arm. In some cases, the wedge system may include a second wedge including a body and an arm extending from the body, and at least a portion of the arm of the second wedge can be disposed in the gap of the first wedge to removably secure the second wedge to the first wedge.

Abstract: A dental implant assembly includes an implant, an abutment, and a fixing element. The implant is placed in the alveolar bone. The abutment is assembled to the implant and includes a tapered position-restricting part and an elastic pressing part. The tapered position-restricting part has an abutment fixing channel substantially matching the tapered position-restricting outer wall of the tapered position-restricting trench. The elastic pressing part includes the elastic pressing structures extended from the tapered position-restricting part. The fixing element includes the fixing head and the fixing rod extended from the fixing head. A tolerance allowable gap is formed between the abutment fixing channel and the fixing rod.

Abstract: Embodiments for estimating a surface texture of a tooth are described herein. One method embodiment includes collecting a sequence of images utilizing multiple light conditions using an intra-oral imaging device and estimating the surface texture of the tooth based on the sequence of images.

Abstract: A dental block for producing a dental prosthesis comprises a green body including zirconia and having a chemical composition including increasing amounts of yttria through a thickness of the green body. The green body has a substantially consistent optical characteristic of chroma and translucency across the thickness, and is subsequently millable and sinterable to form the dental prosthesis with an optical characteristic of decreasing chroma, increasing translucency, and decreasing strength, in one direction through a thickness of the dental prosthesis.

Abstract: A bite rim system includes a plurality of dental bite rims having a shape and size that is suitable for use in a human mouth. A plurality of anatomically correct replica teeth is constructed from wax, and also includes various tooth characteristics of different shapes, thicknesses, sizes and colors. A series of replica teeth are removably pre-mounted onto one or more of the bite rims in an anatomically correct pattern. The system also includes one or more replica teeth strips having a front facing surface with the image of one or more teeth imprinted thereon, and a back facing surface that is coated with an adhesive material for mating with one of the dental bite rims.

Abstract: A flosser is described that includes a take-up spool for winding a plurality of layers of used floss, a shell for forming a chamber around the take-up spool and enclosing the plurality of layers of used floss windings within the chamber, and helical grooves disposed in an inner surface of the shell for preventing jamming of the take-up spool by accumulated floss windings. The flosser further includes a retie assembly having a groove disposed in a fin for trapping floss against a take-up aperture upon alignment of the groove and aperture, and for urging floss into take-up aperture and wrapping the floss around the take-up spool as the fin rotates further.

Abstract: A method of attaching a dental article to the surface of a tooth includes providing the dental article and applying a coating including upconversion phosphors to a surface of the dental article. The method also includes applying a dental cement composition to the surface of the tooth and placing the dental article on the surface of the tooth such that the coating is adjacent the dental cement composition. The dental cement composition includes a polymerizable resin and a photoinitiator and is substantially free of upconversion phosphors. The method further includes irradiating the coating with a radiation source that emits radiation at a pre-determined fixed wavelength that causes the upconversion phosphors to emit radiation at an activation wavelength of the dental cement composition photoinitiator such that the dental cement composition cures in a region adjacent the coating and removing remaining uncured dental cement composition outside the dental article from the tooth.

Abstract: Systems and methods for systems and methods for improvement of a person's performance and well-being by determining and maintaining an orthopedically optimized position of the person's jaw. In one embodiment, TENS is applied to the patient's jaw muscles to relax and deprogram the muscles, the person's TMJs are evaluated and reduced, and neural shear in the patient's upper cervical spine is minimized by orthopedically aligning the patient's head and neck (CC complex), thereby causing the patient's jaw to move toward an orthopedically optimized position (CM complex). A bite registration of the upper and lower jaws is taken, with molars and premolars at least 2 millimeters apart, the front teeth not touching, and preferably a vertical index of 17-21 millimeters. Molds of the persons upper and lower teeth may be positioned using the bite registration, and an orthopedic alignment device (OAD) may be formed between the molds.

Abstract: An oral appliance is provided for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside a mouth. The oral appliance contains an interior surface having a medicament disposed in or on at least a portion of and/or the entire interior surface of the oral appliance. The interior surface of the oral cavity is formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and is configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament to strategic areas in need of treatment. In some embodiments, computer, network and computer readable storage media are provided.

Abstract: The present invention refers to a vaginal device of an elastic material, the vaginal device comprising a longitudinal portion having a geometrical center line, an upper end and a lower end and which vaginal device is intended to be inserted securely fixated inside of a vagina, the upper end being the innermost of the vaginal device in the vagina during use, to support against the urethra, through the vaginal wall, to prevent urinary stress incontinence in a woman, wherein the vaginal device comprises at least one supporting portion protruding from the longitudinal portion and a reference member protruding from the longitudinal portion at the lower end, which reference member during use is fixated against the vaginal introitus, holding the vaginal device securely fixated inside of the vagina and ensuring the at least one supporting portion to support against the urethra.

Abstract: Devices and methods for treating an abdominal incision or hernia are described. An implant for the restoration or prophylactic treatment of an abdominal wall comprises an elongate element and at least one sheet connected to the elongate element along a longitudinal axis of the elongate element. The elongate element is positioned along the line of incision, and the at least one sheet is secured to the abdominal muscles surrounding the incision.

Abstract: The disclosure is generally directed to assemblies and methods that include (1) strips or cords of material configured to lift, restrain, or hold whole body organs (e.g., of a human patient) or parts of body organs in desired positions via tissue anchors (e.g., barbs, hooks, or cones), (2) an introducer device that facilitates the introduction of such strips or cords into a patient, and (3) the process of inserting such strips or cords of material into a patient (e.g., using an introducer device).

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

Abstract: Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In at least one embodiment of an endograft valve device of the present disclosure, the device comprises an endograft body configured for expansion from a collapsed configuration to an expanded configuration within a luminal organ and comprising a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion tapering toward the distal end so that the distal end aperture has a relatively smaller cross-sectional area than the proximal end aperture when the valve device is expanded, and a valve portion positioned at or near the distal end of the first portion, the valve portion configured to receive fluid flowing through the distal end aperture of the first portion.

Abstract: An adjustable construct for fixation of a tendon or ligament graft in a tunnel. The construct comprises a flexible, adjustable loop connected to tissue (for example, graft, ligament or tendon). The adjustable loop may be integrated with an additional tissue supporting device (for example, a wedge or a plug). The tissue is secured within a bone socket/tunnel by adjusting the length of the flexible adjustable loop.

Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.

Abstract: A sewing ring for prosthetic heart valves that is connected and configured to pivot outward. A biocompatible fabric covering surrounds at least a portion of the sewing ring, and the ring may be exclusively connected to a stent with the fabric. The sewing ring may be generally planar and of uniform thickness, or may be of varying thickness. The fabric may be used to encompass both the stent and the sewing ring, and may be a single piece. A seam may be provided in the fabric as a discrete pivoting line. The sewing ring may be convertible between bi-stable positions. The ring may extend outward in a frusto-conical shape so as to enable inversion between a position facing the inflow end of the valve and a position facing the outflow end of the valve. The sewing ring may have a compliant insert having a celled construction defined by outer walls and inner ribs. A method of implantation, and a method of assembly of the heart valve is also provided.

Abstract: Embodiments of the present disclosure provide a prosthetic heart valve and a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. A delivery apparatus for delivering s self-expanding prosthetic valve can be configured to allow controlled and precise deployment of the valve from a valve sheath so as to minimize or prevent jumping of the valve from the valve sheath.

Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

Abstract: A method and device for anchoring a prosthetic heart valve or annuloplasty ring to a valve annulus in a heart and a method of implanting same is disclosed. The device can include a prosthetic valve or annuloplasty ring with one or more anchors configured to be threaded or otherwise passed underneath a native leaflet and/or subvalvular tissue to secure the device at the native annulus.

Abstract: Systems, devices and methods for repairing a native heart valve. In one embodiment, a repair device for repairing a native mitral valve having an anterior leaflet and a posterior leaflet between a left atrium and a left ventricle comprises a support having a contracted configuration and an extended configuration, and an appendage, such as a flap or apron extending from the support. In the contracted configuration, the support is sized to be inserted under the posterior leaflet between a wall of the left ventricle and chordae tendineae. In the extended configuration, the support is configured to project anteriorly with respect to a posterior wall of the left ventricle by a distance sufficient to position at least a portion of the posterior leaflet toward the anterior leaflet, and the appendage is configured to extend beyond an edge of the posterior leaflet toward the anterior leaflet.

Abstract: A method is provided for repairing the tricuspid valve of a patient using tension. A radially-expandable stent is implanted in a coronary sinus of the patient. A tissue anchor is implanted in tissue in the vicinity of the tricuspid valve. The tricuspid valve is repaired by applying tension between the radially-expandable stent and the tissue anchor using a flexible longitudinal member that connects the radially-expandable stent and the tissue anchor.

Abstract: An occlusion device intended for blocking perivalvular leak channels that are found following heart valve implantation between the heart valve and the surrounding tissue. The occlusion device has a stent and a covering that is attached to the stent surface. A blocking fabric extends across the lumen of the stent to block blood flow. The stent pattern and wall structure provide for small radius of curvature bends to fill narrow channels that cause the perivalvular leaks.

Abstract: A system for implanting a repair device onto a native valve of a natural heart to repairing the native valve of a patient during a non-open-heart procedure. The system includes a surgical delivery instrument, a valve repair device, and a gripper control mechanism. The surgical delivery instrument has at least one lumen. The valve repair device is configured to be delivered through the lumen of the surgical delivery instrument and to be attached to a native valve of a patient. The valve repair device includes a pair of paddles, and at least four gripping members. The paddles are movable between an open position and a closed position, and the paddles and the at least four gripping members are configured to attach to the native valve of a patient. The gripper control mechanism is configured to independently move each of the at least four gripping members.

Abstract: An intravascular device configured to be recaptured within a guide catheter has a ring located at the distal end of a delivery catheter. The ring has an outer diameter greater than that of the delivery catheter and a sloped guide surface near the outer edge of the ring to urge the ring and delivery catheter toward a radially centered position within the guide catheter.

Abstract: Methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. A delivery device for delivering an implantable device to a target area includes a fluid management system for directing fluid and delivery device components to the target area. The delivery device includes a grip line assembly configured to control a gripper in the implantable device for grasping tissue at the target area. The delivery device includes a lock line assembly configured to control a locking mechanism in the implantable device to lock the implantable device in a desired orientation. The delivery device includes a deployment handle configured to provide staged deployment of the implantable device. A delivery assembly includes a housing and a delivery device partially housed within the housing and being adjustable using one-handed operation.