Abstract: A light-emitting device includes a light-emitting element with a peak emission wavelength in a range of 400 nm to 410 nm and a fluorescent member that contains a first phosphor with a peak emission wavelength in a range of 440 nm to 470 nm containing a Eu-activated alkaline-earth phosphate that contains Cl in a composition, a second phosphor with a peak emission wavelength in a range of 500 nm to 530 nm containing a Eu-activated halogen-containing alkaline-earth silicate, a third phosphor with a peak emission wavelength in a range of 530 nm to 600 nm containing a Ce-activated rare-earth aluminate, and a fourth phosphor with a peak emission wavelength in a range of 600 nm to 660 nm containing a Eu-activated silicon nitride containing Al and at least one of Sr and Ca in a composition.

Abstract: An arrangement for disinfecting can lids and for closing cans includes a feed device which feeds a can closing unit. Receiving portions for individual can lids are arranged in the feed device. The feed device is situated in the feed region of the can closing unit. At least one sterilization device, for can lids received individually in the feed device, is arranged in a conveying region of the feed device.

Abstract: There are provided a sterilization method and a sterilization device capable of effectively sterilizing a sterilization target having an uneven shape formed by a dented portion and a protruded portion. A sterilization method and a sterilization device configured to apply ultraviolet light to a sterilization target having an uneven shape ormed by a dented portion and a protruded portion include plural light sources each including an LED element configured to apply ultraviolet light. Ultraviolet light is simultaneously applied from each of the plural LED elements in a state where the sterilization target arranged at previously set irradiation positions face the plural light sources, and reaches the sterilization target.

Abstract: A variety of applications for UV LEDs that are integrated into a system are described, where the UV light is used for disinfection of air or surfaces, or used to detect the scattering light by particles, or used for skin treatment. In one embodiment, a ceiling luminaire includes a sensor for detecting the presence of people in the room. The luminaire contains a first set of LEDs for generating white light, for illumination, and a second set of LEDs for generating UV light for disinfecting the room. When the sensor detects that no people are in the room, the system automatically controls the UV LEDs to turn on to disinfect the room. The white light LEDs may be independently controlled with a dimmer.

Abstract: A vacuum sterilization device includes a vacuum pump, an ozone generator, a connector and a panel. The vacuum pump is connected to a vacuum electro-magnetic valve, and the vacuum electro-magnetic valve is connected to the connector. The ozone generator is connected to an ozone electro-magnetic valve which is connected to the connector as well. The vacuum sterilization device vacuums a pack and then introduces ozone into the pack. After the ozone sterilizes the interior of the pack, the vacuum pump sucks the ozone from the pack. The users can set the time required and expected results of the ozone on the panel.

Abstract: The present disclosure relates to methods and system for disinfecting surfaces within a volumetric space by forming peracids in a reaction layer in situ directly on the surfaces to be disinfected. Particularly, a peroxide compound and an organic acid are sequentially dispersed into the volumetric space, preventing peracids from being formed until the two reactants contact each other on the surface to be disinfected. In some embodiments, any of the dispersed aqueous compositions can optionally be electrostatically charged. Additionally, a system for sequentially dispersing the peracid reactant compounds by electrostatic spraying is provided.

Abstract: A sterilization package includes a first package layer and a second package layer coupled to the first package layer with a perimeter seal extending around a portion of the sterilization package to define a pouch having a proximal end and a distal end. A first sterilization indicium is disposed on the second package layer exterior of the pouch and a second sterilization indicium is disposed on the second package layer interior of the pouch. The first and second sterilization indicia are multi-parameter sterilization indicia configured to be responsive to a sterilization process such that the first and second sterilization indicia undergo a visual change to a desired ending color when the package is subjected to complete multi-parameter sterilization conditions.

Abstract: A method for reducing odor in waste products by adding an acidic ion exchange resin to an absorbent which is in contact with said waste products.

Abstract: Aspects of the disclosure include an attachment for providing a scent to a container. In some aspects, a scent delivery system includes a bottle including a collar and a ledge structure each extending circumferentially outward; a scent ring loaded with a volatile chemical agent to emanate and generate a scent and including an interior protruding structure projecting from an interior wall of the ring, the scent ring configured to fasten around the neck of the bottle based on contact between the interior protruding structure and the ledge structure of the bottle; and a cap reversibly attachable to the bottle and including an interior rim structure that circumferentially projects from the interior of the cap, where the cap is structured to enclose the scent ring in a compartment formed between the collar and the interior rim structure when the cap is securely fastened to the bottle and trap the scent.

Abstract: A refill for dispensing a volatile material includes a bottle having a body defined by at least one sidewall and a neck extending outwardly from the at least one sidewall. The neck includes a rim at an upper end thereof, the neck being defined by an inner surface, a top surface, and an outer surface. The refill further includes a plug and a wick having a first end positioned within the bottle and a second end extending out of the bottle, the wick further defining a longitudinal axis. The plug is coupled to the neck of the bottle, the plug retaining the wick within the bottle. At least a portion of the inner surface of the rim is tapered at an angle of between about 2 and about 9 degrees with respect to the longitudinal axis.

Abstract: A refill for dispensing a volatile material includes a bottle having a body defined by at least one sidewall and a neck extending from the body. The neck includes a rim at an upper end thereof and has an inner surface, a top surface, and an outer surface. A wick has a first end positioned within the bottle and a second end extending out of the bottle. A plug assembly is secured to the neck of the bottle and retains the wick within the bottle. A cap is coupled with the neck of the bottle. An underside of the cap includes a stop and a flange that form a seal with the plug assembly when the refill is in an assembled configuration.

Abstract: A method is for making a hemostat device. The method includes preparing a homogenous solution of gelatin and chitosan by adding gelatin to water to form a gelatin solution, adding an acid to the gelatin solution to provide an acidified gelatin solution, and adding chitosan to the acidified gelatin solution to form the homogenous solution of gelatin and chitosan. The method also may include air drying the homogenous solution of gelatin and chitosan to provide an air dried scaffold, processing the air dried scaffold to provide a porous sponge, loading the porous sponge with a clotting agent by exposing the porous sponge to the clotting agent in an aqueous solution, and drying the loaded porous sponge.

Abstract: The present invention is directed to a biocompatible adhesive system comprising a) a hydrogel comprising a first polymer network and a second polymer network, wherein the first polymer network comprises covalent crosslinks and the second polymer network comprises ionic crosslinks; b) a high density primary amine polymer; and c) a coupling agent. The present invention also provides methods preparing and using the biocompatible adhesive system.

Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.

Abstract: A device for wound healing or tissue repair comprising collagen and a tetracycline compound which is effective for preventing or controlling a fungal infection.

Abstract: Disclosed herein is a wound dressing having a wound-contacting surface comprising a KAP-enriched keratin material in the form of a hydrogel or a coating on a substrate wherein said KAP content facilitates accelerated wound healing of chronic wounds that exhibit excessive or persistence proteolytic enzyme activity.

Abstract: Described herein are fenestrated placental tissue allografts, methods for using the same for treating wounds that produce an exudate and to promote the healing process, and apparatus and kits for making the same that minimize or eliminate cross-contamination with placental tissue from other placental donors.

Abstract: Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may be designed to exhibit osteogenic, osteoinductive, osteoconductive, and/or osteostimulative properties.

Abstract: The present invention provides methods and compositions for promoting dental tissue repair and/or regeneration, methods for promoting differentiation of dental pulp stem cells, methods for treating periodontal diseases, and methods for treating infection of a dental pulp in a subject in need thereof by contacting the tissue with a composition comprising a triacrylate capable of promoting dental pulp stem cells adhesion and/or proliferation.

Abstract: A method of treating a lesion in a gastrointestinal tract and an injectate system are provided. The method includes injecting a crosslinkable gel into a first tissue layer, the crosslinkable gel increasing a volume of the first tissue layer. The method also includes providing a crosslinker and resecting a portion of a first tissue layer having the increased volume away from a second tissue layer creating an exposed region in a remaining portion of the first layer and leaving a portion of the gel covering at least a portion of the exposed region. The injectate system includes a crosslinkable gel and a crosslinker where the crosslinkable gel and the crosslinker form a crosslinked gel having a compressive modulus of about 10-500 kPa.

Abstract: Inventive concepts relate generally to the field of implantable urological devices, and more particularly to compositions that inhibit crystallization of urine components. Described are implantable urological devices including a surface and a crystallization inhibitor composition, the crystallization inhibitor composition including: (a) an inhibitor of urine component crystallization in combination with a biodegradable polymer, or a polyalkene homopolymer or copolymer, or (b) a biodegradable polymer that includes an inhibitor of urine component crystallization, wherein the crystallization inhibitor composition provides controlled release of the inhibitor of urine component crystallization from the surface of the device into a subject. Methods of making the implantable urological devices are also described.

Abstract: Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.

Abstract: The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.

Abstract: In an embodiment, a method for loading a powder substance (10) into recesses (200) provided at a stent (S) surface, the method comprises: applying compression (100) to the powder substance (10) to thereby form tablets insertable into said recesses (200), inserting the tablets into the recesses (200) of the stent (S).

Abstract: Provided herein are catheter lock solutions having anticoagulation and antimicrobial properties, the catheter lock solutions including citrate salts. The citrate salt can be trisodium citrate, and the catheter lock solution can further include a diluted acid for adjusting the pH of the catheter lock solution.

Abstract: A biocompatible material, which has excellent film formation properties and resistance to water dissolution, and is easily applied on various bases as a coating, while having excellent antithrombotic properties, and to provide an antithrombotic coating agent and an antithrombotic coating film produced by using the biocompatible material, and a medical device provided with the antithrombotic coating film. A copolymer, containing at least one repeating unit (A) represented by formula (1) (wherein, n represents an integer of 2 to 10 and R1 represents a methyl group or an ethyl group), and at least one repeating unit (B) represented by formula (2) (wherein R2 represents an aliphatic hydrocarbon group); an antithrombotic coating agent containing the copolymer and an organic solvent; an antithrombotic coating film formed of the copolymer; and a medical device provided with the coating film.

Abstract: Some embodiments have a pump assembly mounted to or supported by a dressing for reduced pressure wound therapy. The dressing can have visual pressure, saturation, and/or temperature sensors to provide a visual indication of the level of pressure, saturation, and/or temperature within the dressing. Additionally, the pump assembly can have a pressure sensor in communication with the flow pathway through the pump, and at least one switch or button supported by the housing, the at least one switch or button being accessible to a user and being in communication with the controller. The pump assembly can have a controller supported within or by the housing, the controller being configured to control an operation of the pump. The pump can be configured to be sterilized following the assembly of the pump such that all of the components of the pump have been sterilized.

Abstract: A negative pressure device includes a drape, a wicking element, a sealing element, a reactor, a chamber and an air permeable liquid impervious element. The drape includes an opening and is made from a flexible material that inhibits passage of liquid and air through the drape other than through the opening. The wicking element is covered by the drape. The sealing element surrounds the wicking element and cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. Air within the enclosed volume is inhibited from exiting the enclosed volume other than through the opening. The reactor is configured to react with a gas found in air to consume the gas. The chamber is in fluid communication with the reactor and the enclosed volume via the opening. The chamber is configured to maintain a predefined chamber volume while the gas is being consumed from the enclosed volume.

Abstract: A wound treatment appliance is provided for treating all or a portion of a wound. In some embodiments, the appliance comprises a cover or a flexible overlay that covers all or a portion of the wound for purposes of applying a reduced pressure to the covered portion of the wound. In other embodiments, the wound treatment appliance also includes a vacuum system to supply reduced pressure to the site of the wound in the volume under the cover or in the area under the flexible overlay. Methods are provided for using various embodiments of the invention.

Abstract: A flow control system may include an inner nosecone having an inner nosecone distal end and an inner nosecone proximal end, an outer nosecone having an outer nosecone distal end and an outer nosecone proximal end, an aperture of the outer nosecone, a gasket having a gasket distal end and a gasket proximal end, a gasket aperture of the gasket, a gasket seal of the gasket, a flow control mechanism having a flow control mechanism distal end and a flow control mechanism proximal end, and a control aperture of the flow control mechanism. A rotation of the flow control mechanism about the gasket may be configured to decrease an aspiration flow rate. A rotation of the flow control mechanism about the gasket may be configured to increase an aspiration flow rate.

Abstract: An apparatus and method for cleansing and applying therapy or prophylaxis to wounds, in which irrigant fluid, which may contain a physiologically active material, and wound exudate from the dressing are moved by a device for moving fluid through a flow path which passes through the dressing. A means for fluid cleansing may also be provided to recirculate fluid back to the dressing. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The apparatus may also provide means for distributing such materials in a precise and time-controlled manner over the wound bed.

Abstract: An adipose tissue (AT) transfer system includes, on the aspiration side, an aspiration cannula, an aspiration pump, a container, and flexible tubing connecting the aspiration cannula to the container. On the reinjection side, the system includes a reinjection cannula, flexible tubing connecting the inlet of the reinjection cannula to the container, and a reinjection pump imposing positive-displacement pumping action on the flexible tubing and causing movement of AT in a continuous or pulsed mode. The aspiration pump operates to continually supply harvested AT to the second flexible tubing while the reinjection pumps causes continuous or pulsed deposition of the AT at the injection site.

Abstract: An apparatus and system for treating a wound having a cavity is disclosed. The apparatus comprises a scaffold including a scaffold lamina and a tissue lamina wherein the scaffold lamina forms a laminate in fluid communication with the tissue lamina. The laminate is rolled into a generally cylindrical shape having two end surfaces. The apparatus further comprises a manifold having a port for coupling to a source of reduced pressure and that is positioned in fluid communication with the scaffold to provide reduced pressure to the scaffold lamina and the wound. The apparatus also comprises a drape formed of substantially impermeable material to cover the scaffold and the manifold within the wound.

Abstract: A treatment system for applying negative pressure to a tissue site in conjunction with a venting or purging capability. In some embodiments, the treatment system may include a reduced-pressure source, an inline storage pouch, a purge chamber, and a dressing. Reduced-pressure may be supplied to the inline storage pouch and the dressing, while the purge chamber may provide a ventilation opening to the atmosphere.

Abstract: A driveline for an implantable blood pump including a percutaneous outer tube configured to connect with the blood pump when the blood pump is implanted within a body of a patient and an external controller outside of the body of the patient and at least one ultra-violet light emitter coupled to the outer tube.

Abstract: A driveline for an implantable blood pump including a percutaneous connector including an outer tube, the outer tube defining an exterior surface and having a proximal portion and a distal portion opposite the proximal portion, the proximal portion being couplable to the implantable blood pump disposed within a body of a patient and the distal portion being couplable to a controller outside of the body of the patient and at least one electronic instrument coupled to the outer tube and fluidically sealed from the exterior surface.

Abstract: A method of estimating an amount of work available to be performed by a blood pump implanted in a patient includes calculating a first coordinate value characterizing a volume of blood impelled in the pump and a second coordinate value characterizing a differential pressure across the pump for each of a plurality of flow rate data points of a given cardiac cycle of the patient, each flow rate data point indicative of a flow rate of blood through the pump. An area enclosed by the first and second coordinate values of the plurality of flow rate data points is determined, the determined area being indicative of an amount of work available to be performed by the blood pump.

Abstract: In a multi-sensor device for a medical apparatus at least one first sensor unit and at least one second sensor unit are arranged at a fluid-guiding line connection along which the sensor units detect at least one variable from a flowing fluid in predetermined proximity to each other in such manner that predetermined signal portions occur and are detectable practically simultaneously in outputs of each of the first and second sensor units. In a method for defining a proximity in said multi-sensor device, positions of the individual sensors are varied in the multi-sensor device and the occurrence of predetermined signal portions is detected in at least two signals detected by the individual sensors, and those positions at which the predetermined signal portions occur practically simultaneously are defined as positions of the proximity.

Abstract: Devices, systems, and methods herein relate to performing dialysis to manage a chronic condition such as end-stage renal disease. These systems and methods may allow a patient to orally ingest a potable dialysate and excrete the dialysate via the urinary tract. In some variations, a method may include delivering a dialysate via the esophagus of a patient and draining the dialysate into a bladder of the patient. Delivering the dialysate may further comprise delivering the dialysate through the nasopharynx or oropharynx. Delivering the dialysate through the oropharynx may comprise the patient drinking the dialysate.

Abstract: A portable dialysis cabinet for use in dialysis. The portable dialysis cabinet can have a size and weight that facilitates easy movement of the cabinet from one location to another with relative ease. The portable dialysis cabinet can have additional features necessary to facilitate portability, such as wheels and a handle. In general, the portable dialysis cabinet can contain all the necessary components for performing a dialysis session.

Abstract: A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.

Abstract: A syringe rack securable to a surface of a fixture and configured for facilitating a sterile transfer of fluid from a non-sterile environment to a sterile environment. The syringe rack includes a securing portion and a syringe-receiving station. The syringe-receiving portion is coupled to the securing portion and configured to receive the syringe in a selectively releasable coupling arrangement where the syringe is oriented such that an opening in a barrel of a syringe projects away from the fixture when the syringe is received by the syringe-receiving station and when the securing portion is secured to the surface of the fixture.

Abstract: An intravenous (IV) pole assembly comprising: an IV pole having a pole, a plurality of hooks mounted to the pole, and a base with a plurality of wheels, wherein the plurality of hooks are for holding a container of intravenous fluid; and a decorative equipment including a decorative element and a connector bracket attached to the decorative element, the connector bracket for mounting on a top of the pole, the connector bracket comprises a shaft that defines a plurality of slots on one end of the shaft.

Abstract: Disclosed are various embodiments for illuminated medical infusion including, for example, a medical infusion system which includes a source of illumination and an illuminating infusion line and wherein the illuminating infusion line includes an integrated fluid transmission channel and light transmission channel.

Abstract: An infusion system for infusing a medication in a patient, comprising a medication dose dispensing device and a control device for controlling the dispensing device. The infusion system can be configured in a non-operating configuration, in which the dispensing device and the control device are spaced apart from each other, and in an operating configuration, in which the dispensing device and the control device are temporarily proximity-coupled. The actuating rotor of the control device and the actuated rotor of the dispensing device have a common rotation axes, and the system can compensate or block the rotation of the control device with respect to the dispensing device.

Abstract: A wearable, refillable transdermal drug delivery system is disclosed herein. The system may be generally comprised of a pocket or channel disposed on a garment, and a delivery cartridge containing a predetermined amount of a drug to be delivered. The delivery cartridge may be sized to be frictionally fit in the pocket or channel of the garment.

Abstract: A system and method for monitoring and delivering medication to a patient includes a controller that has a control algorithm and a closed loop control that monitors the control algorithm. A sensor is in communication with the controller and monitors a medical condition. A rule base application in the controller receives data from the sensor and the closed loop control and compares the data to predetermined medical information to determine the risk of automation of therapy to the patient. The controller then provides a predetermined risk threshold where below the predetermined risk threshold automated closed loop medication therapy is provided. If the predetermined risk threshold is met or exceeded, automated therapy adjustments may not occur and user/clinician intervention is requested.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves obtaining measurement values for a physiological condition influenced by the fluid, autonomously operating the infusion device to deliver the fluid based at least in part on the measurement values, and detecting a nonactionable condition based on the measurement values. In response to detecting the nonactionable condition, delivery of the fluid is limited while maintaining autonomous operation of the infusion device. In one exemplary embodiment, the nonactionable condition is a rescue condition indicative of the user having consumed fast-acting carbohydrates, and thus insulin delivery may be automatically limited in response to detecting the rescue carbohydrate consumption.

Abstract: Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.