Patents Issued in April 18, 2019
  • Publication number: 20190111388
    Abstract: A catalytic reactor including: catalytic cassettes each including a catalyst part configured to reduce NOx in exhaust gas and an outer peripheral part made of a frame covering side surfaces of the catalyst part; and a lattice frame on which the catalytic cassettes are placed. The lattice frame includes a plurality of inflow holes through which exhaust gas flows into the catalyst parts and a plurality of frame parts which defines the respective plurality of inflow holes. The outer peripheral part of each of the catalytic cassettes is positioned so that the outer peripheral part is accommodated in a respective one of the frame parts.
    Type: Application
    Filed: August 23, 2016
    Publication date: April 18, 2019
    Applicant: Yanmar Co., Ltd.
    Inventors: Tetsuya YOKOYAMA, Arata HAYATA, Ryota KOBAYASHI
  • Publication number: 20190111389
    Abstract: A three-way catalyst article, and its use in an exhaust system for internal combustion engines, is disclosed. The catalyst article for treating exhaust gas comprising: a substrate; and a catalytic region on the substrate; wherein the catalytic region comprises a first platinum group metal (PGM) component, an oxygen storage component (OSC) material, a rare earth metal oxide, and an inorganic oxide; and wherein the rare earth metal oxide has an average diameter (d50) of more than 100 nm.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 18, 2019
    Inventors: Kenneth CAMM, Hsiao-Lan CHANG, Hai-Ying CHEN, Michael HALES, Kwangmo KOO
  • Publication number: 20190111390
    Abstract: A method of regenerating an ammonium bicarbonate solution includes supplying a diluted ammonium bicarbonate solution to an upper portion of a distillation unit, an upper portion of an ammonia condenser, and an upper portion of an absorber; distilling the diluted solution to discharge a first gas mixture, supplying the first gas mixture to a lower portion of the ammonium condenser; bringing the first gas mixture into contact with the diluted solution to be separated into a first mixed solution and a second gas mixture, supplying the first mixed solution to the upper portion of the absorber, and supplying the second gas mixture to a lower portion of the absorber; and bringing the second gas mixture into contact with the diluted solution supplied to the upper portion of the absorber and the first mixed solution supplied to the upper portion of the absorber to recover a concentrated ammonium bicarbonate solution.
    Type: Application
    Filed: November 4, 2016
    Publication date: April 18, 2019
    Inventor: Ki-Joon KANG
  • Publication number: 20190111391
    Abstract: A wet cleaning apparatus that cleans an item with carbon dioxide gas-dissolved water produced by dissolving carbon dioxide gas in ultrapure water, the wet cleaning apparatus including: a carbon dioxide gas-dissolving unit that dissolves carbon dioxide gas in ultrapure water; a cleaning unit that cleans an item, the cleaning unit receiving carbon dioxide gas-dissolved water fed from the carbon dioxide gas-dissolving unit; and a filtration membrane module disposed on a pipe through which the carbon dioxide gas-dissolved water is fed to the cleaning unit, the filtration membrane module being filled with a porous membrane including a cationic functional group.
    Type: Application
    Filed: March 24, 2017
    Publication date: April 18, 2019
    Inventors: Hideaki IINO, Koji NAKATA, Masayuki KANEDA, Daisuke SATO
  • Publication number: 20190111392
    Abstract: Various examples are related to smart membranes for monitoring membrane based process such as, e.g., membrane distillation processes. In one example, a membrane, includes a porous surface and a plurality of sensors (e.g., temperature, flow and/or impedance sensors) mounted on the porous surface. In another example, a membrane distillation (MD) process includes the membrane. Processing circuitry can be configured to monitor outputs of the plurality of sensors. The monitored outputs can be used to determine membrane degradation, membrane fouling, or to provide an indication of membrane replacement or cleaning. The sensors can also provide temperatures or temperature differentials across the porous surface, which can be used to improve modeling or control the MD process.
    Type: Application
    Filed: April 3, 2017
    Publication date: April 18, 2019
    Inventors: Taous Meriem LALEG, Ayman Mustafa KARAM
  • Publication number: 20190111393
    Abstract: A spiral-wound electrodialysis module includes an inner electrode positioned about a central axis and an outer electrode surrounding the inner electrode. Ion exchange membranes are arranged in a stack, and each membrane extends in a spiral outward from an inner position proximate the inner electrode to an outer position proximate the outer electrode. The spirals expand outward at a greater-than-linear rate as a function of angle along a length of the spiral from the inner positions to the outer positions.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Amos G. Winter, Natasha Catherine Wright
  • Publication number: 20190111394
    Abstract: Devices and methods for the filtration of particulates from a liquid stream are provided. A filter cartridge includes a housing configured to be placed in-line with a stream of liquid and a plurality of hollow fiber filter members disposed within the housing. The hollow fiber filter members are potted at one end of the housing and configured to capture particulates from the stream of liquid via surface energy. The filter cartridge can provide low pressure loss filtering and is capable of being placed within a small space.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 18, 2019
    Inventors: Yasushi Ohyashiki, Satoshi Kamimoto
  • Publication number: 20190111395
    Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.
    Type: Application
    Filed: April 20, 2017
    Publication date: April 18, 2019
    Inventors: Kurt E. Greenizen, Christopher A. Scott, Paul Sydlowski, John Doyle, Ryan A. Amara
  • Publication number: 20190111396
    Abstract: In at least one embodiment, a membrane filtration element is provided. The element may include at least one feed spacer including a first set of parallel strands extending in a first direction and including a plurality of first strands having a first thickness and a plurality of second strands having a second thickness that is smaller than the first thickness. A second set of parallel strands may extend in a second direction that is transverse to the first direction. The second set of parallel strands may include a plurality of third strands having a third thickness and a plurality of fourth strands having a fourth thickness that is smaller than the third thickness. In one embodiment, the first and second sets of strands include alternating thick and thin strands, which reduce pressure drop in membrane filtration systems.
    Type: Application
    Filed: July 20, 2018
    Publication date: April 18, 2019
    Inventor: Alexander James Kidwell
  • Publication number: 20190111397
    Abstract: Provided is a membrane module which has a simple and easy structure to restrain its vessel from being increased in costs, and which allows to fabricate the vessel by a simple and easy work, and further to locate an inlet for a fluid, and others at respective predetermined positions of the membrane module.
    Type: Application
    Filed: February 24, 2017
    Publication date: April 18, 2019
    Applicant: Nitto Denko Corporation
    Inventors: Yasuhiro UDA, Kentarou KOBAYASHI
  • Publication number: 20190111398
    Abstract: Spin columns that include a poly(acid) membrane separation matrix are provided. Also provided are kits that include the subject devices, as well as methods of using the devices, e.g., in sample preparation (such as protein purification) protocols.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: George G. Jokhadze, Sayantan Mitra
  • Publication number: 20190111399
    Abstract: Disclosed herein are spacers having baffle designs and perforations for efficiently and effectively separating one or more membrane layers a membrane filtration system. The spacer includes a body formed at least in part by baffles that are interconnected, and the baffles define boundaries of openings or apertures through a thickness direction of the body of the spacer. Alternatively or additionally, passages or perforations may be present in the spacer layer or baffles for fluid flow there through, with the passages and baffles having a numerous different shapes and sizes.
    Type: Application
    Filed: April 4, 2017
    Publication date: April 18, 2019
    Inventors: Noreddine GHAFFOUR, Adnan QAMAR
  • Publication number: 20190111400
    Abstract: Systems, apparatuses, and methods for making content liquid foamy for discharge are described herein. A dispenser for making content liquid discharge foamy by mixing air flow from an air chamber with the content liquid flow from a liquid chamber can be provided. The dispenser can comprise a mixing chamber configured to mix air and content liquid; a porous member between an air passage from the air chamber and the mixing chamber; and a liquid passage from the liquid chamber to the mixing chamber. The liquid passage can have a first liquid passage and a plurality of second liquid passages. The liquid passage can be configured such that content liquid flows from the first liquid passage to the second liquid passages to the mixing chamber. The second liquid passages can be configured to provide flow of the content liquid in at least two directions.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Applicant: KAO CORPORATION
    Inventors: Chris KING, Ryohei Aoyama, Noboru Yashima
  • Publication number: 20190111401
    Abstract: In accordance with presently disclosed embodiments, systems and methods for efficiently handling dry additives to be mixed with bulk material in a blender are provided. The systems may include a support structure used to direct bulk material from one or more portable containers on the support structure to a first outlet location, and a combined metering/transferring system for directing dry additives from another portable container to a second outlet location. Specifically, the metering/transferring system may output a metered flow of dry additives to the blender mixer to be combined with bulk material that is released from the portable containers. The metering/transferring system may utilize a gravity feed outlet coupled to a metered screw or other conveying device to move the dry additive from the portable container to the second outlet location.
    Type: Application
    Filed: May 24, 2016
    Publication date: April 18, 2019
    Inventors: Bryan Chapman Lucas, Wesley John Warren, Calvin L. Stegemoeller, Austin Carl Schaffner
  • Publication number: 20190111402
    Abstract: The present application relates to an improved apparatus for mixing intensification in multiphase systems, which can be operating in continuous or batch mode. In particular, it relates to a reactor, which can be assembled and disassembled easily for cleaning. The apparatus is based on oscillatory flow mixing (OFM) and comprises an oscillatory flow plate reactor (OFPR) provided with 2D Smooth Periodic Constrictions (2D-SPCs). The apparatus can be fully thermostatized and it is based on a modular system, in order to achieve most of the industrial application. The OFPR is suitable for multiphase applications such as screening reactions, bioprocess, gas-liquid absorption, liquid-liquid extraction, precipitation and crystallization.
    Type: Application
    Filed: April 10, 2017
    Publication date: April 18, 2019
    Inventors: Antonio Manuel AZEVEDO FERREIRA, Femando Alberto NOGUEIRA DA ROCHA, Jose Antonio COUTO TEIXEIRA, Filipa Juliana Femandes CASTRO FREITAS
  • Publication number: 20190111403
    Abstract: Microcapsules with a plurality of functionalities on the surface, an article of manufacture including microcapsules with a plurality of functionalities on the surface, and a method of forming a microcapsule with a plurality of functionalities on the surface which includes: providing one or more microcapsules; forming one or more wax particles, the wax particles including a wax core with the one or more microcapsules partially embedded in the wax core; functionalizing a first exposed surface of the one or more microcapsules; removing the functionalized one or more microcapsules from the wax core; and functionalizing a second exposed surface of the functionalized one or more microcapsules, the second exposed surface previously embedded in the wax core are disclosed.
    Type: Application
    Filed: October 18, 2017
    Publication date: April 18, 2019
    Inventors: Eric Campbell, Jason Wertz, Brandon Kobilka, Sarah Czaplewski
  • Publication number: 20190111404
    Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
    Type: Application
    Filed: November 14, 2013
    Publication date: April 18, 2019
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20190111405
    Abstract: Provided is an ion wind generation device which is capable of providing a wide range of ion delivery and providing ion wind having a reduced ozone concentration near a nozzle without use of a filter or the like. The ion wind generation device includes an electrode pair including a discharge electrode body having a discharge portion and a counter electrode body having a plurality of end portions, and generates ion wind by corona discharge that occurs due to a potential difference generated between the discharge portion and the end portions. The end portions are located spaced apart from one another in a single plane and disposed around an axis of the discharge electrode body in the single plane or disposed along a line in the single plane.
    Type: Application
    Filed: February 8, 2017
    Publication date: April 18, 2019
    Inventor: Akio KATANO
  • Publication number: 20190111406
    Abstract: A reaction chamber for a chemical reactor comprises a casing (100) of the reaction chamber, a floor (200) of the reaction chamber having an opening (300) located in the floor, an agitator shaft (400) located in the chamber and having at least one agitator element (500), connected thereto, wherein the agitator shaft (400), seen in the longitudinal direction, has a beginning (600) and an end (700). In the opening (300) of the floor (200) a removable sleeve (800) is provided, which projects out of the reaction chamber. The sleeve (800) is arranged in alignment with the axis of rotation of the agitator shaft (400). The internal diameter of the sleeve (800) is greater than the diameter of the agitator shaft (400) and the agitator shaft (400), at the beginning (600) thereof and/or at the end (700) thereof, is adapted to absorb reversibly a torque provided by means of a further shaft and/or to transmit a torque to a further shaft.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Inventors: Leslaw MLECZKO, Sigurd BUCHHOLZ, Karl-Robert BOOS, Sebastian FALSS
  • Publication number: 20190111407
    Abstract: The present invention relates to a reactor for production of synthesis gas that optionally has a fluid-tight connection to a heat exchanger, and to a process for producing synthesis gas, preferably under high pressure.
    Type: Application
    Filed: March 21, 2017
    Publication date: April 18, 2019
    Applicant: KARLSRUHER INSTITUT FUER TECHNOLOGIE
    Inventors: Peter PFEIFER, Paolo PIERMARTINI, Tim BOELTKEN, Robin DUERRSCHNABEL
  • Publication number: 20190111408
    Abstract: A composition for use in brine formation comprising a deliquescent desiccant, urea, and an optional component selected from the group consisting of starch, citric acid, clay, glucose, and a combination thereof. Methods of making and using the composition are provided. The composition may be pressed into tablet form. The composition may be used in a dehumidifying device.
    Type: Application
    Filed: October 11, 2018
    Publication date: April 18, 2019
    Inventors: Rachel Ann Farmer, Dennis Earl Shireman, Charles L. Hawes, Brett Justin Healey, Matthew Michael Petkus
  • Publication number: 20190111409
    Abstract: An adsorption material which includes a carbon nanohorn aggregate in which a plurality of single-walled carbon nanohorns aggregate in a fibrous state, particularly coexisting a globular carbon nanohorn aggregate and some of the single-walled carbon nanohorns included in the carbon nanohorn aggregate have an opening portion, is used. The adsorption material including such a fibrous carbon nanohorn aggregate is produced by a method including: preparing an inert gas atmosphere, a nitrogen gas atmosphere or a mixed atmosphere in a vessel in which a catalyst-containing carbon target is placed; and evaporating the target to obtain a carbon nanohorn aggregate including a fibrous carbon nanohorn aggregate in which a plurality of single-walled carbon nanohorns aggregate in a fibrous state.
    Type: Application
    Filed: February 28, 2017
    Publication date: April 18, 2019
    Applicant: NEC Corporation
    Inventor: Ryota YUGE
  • Publication number: 20190111410
    Abstract: The present invention relates to metal-organic gels and metal-organic aerogels made of dithiooxamidate (DTO) or rubeanate ligand-based coordination polymers, method for preparing thereof and use in chemical species capture, separation and/or catalysis, environmental cleanup, metal recovery, passive sampling, among others.
    Type: Application
    Filed: April 26, 2017
    Publication date: April 18, 2019
    Inventors: Daniel VALLEJO SÁNCHEZ, Garikoitz BEOBIDE PACHECO, Oscar CASTILLO GARCÍA, Sonia PÉREZ YÁÑEZ, Mónica LANCHAS GONZÁLEZ, Antonio LUQUE ARREBOLA, Pascual ROMÁN POLO
  • Publication number: 20190111411
    Abstract: The purpose of the present invention is to provide a particulate water absorbing agent having both a high water absorption multiplying factor and a high water absorption rate and a method for manufacturing the same. The present invention is a particulate water absorbing agent for which CRC is 30 to 50 g/g, wherein the weight average particulate diameter (D50) is 200-600 ?m, and the DRC index given by the following formula is a specific value (for example, 43, 30, or 20) or less: DRC index=(49?DRC5min [g/g])/(D50 [?m]/1000).
    Type: Application
    Filed: March 28, 2017
    Publication date: April 18, 2019
    Inventors: Kazushi TORII, Mariko TAMAKI, Daisuke TAKAGI, Yuichiro HORIMOTO, Taishi KOBAYASHI, Taku FUJIMOTO, Takahiro KITANO, Taku IWAMURA, Hiroki KAWADA, Hiroyuki GOTO, Yasuhisa NAKAJIMA, Hiroyuki IKEUCHI
  • Publication number: 20190111412
    Abstract: A polymeric hydrogel microparticle that contains polyacrylamide and chitosan, the chitosan uniformly incorporated in a polyacrylamide matrix. The microparticle, having a coefficient variation of 0 to 2% and containing macropores with an average size of 1 to 60 nm, is capable of transporting biomolecules conjugated to it. Also disclosed are a method of fabricating such a micro-particle in a micromold via photo-induced radical polymerization and a one-pot method of conjugating biomolecules to polymeric hydrogel microparticles.
    Type: Application
    Filed: March 22, 2017
    Publication date: April 18, 2019
    Inventors: Hyunmin Yi, Eunae Kang, Sukwon Jung, John H. Abel
  • Publication number: 20190111413
    Abstract: A process for the preparation of a catalyst composition for catalysing hydrogenation and hydrogenolysis reactions wherein, (a) a carbon support is contacted with a catalyst precursor solution comprising at least one element from groups 7, 8, 9, 10 and 11 of 5 the periodic table to form a metal impregnated carbon; (b) the metal impregnated carbon is dried at a temperature of no greater than 400° C. and placed in a reactor vessel; (c) the reactor vessel is sealed; and (d) the metal impregnated carbon is treated in the reactor 10 vessel in an atmosphere comprising hydrogen at a temperature of from 25° C. to 350 ° C.
    Type: Application
    Filed: April 7, 2017
    Publication date: April 18, 2019
    Inventors: Hendrik Albertus COLIJN, Dionysius Jacobus Maria DE VLIEGER
  • Publication number: 20190111414
    Abstract: Disclosed are novel bridged bi-aromatic phenol ligands and transition metal catalyst compounds derived therefrom. Also disclosed are methods of making the ligands and transition metal compounds, and polymerization processes utilizing the transition metal compounds for the production of olefin polymers.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Applicant: Univation Technologies, LLC
    Inventors: Catherine Anne Faler, C. Jeff Harlan
  • Publication number: 20190111415
    Abstract: A catalyst for synthesizing hydrogen peroxide is provided. The catalyst includes first material capable of dissociating hydrogen molecules; and second material capable of suppressing dissociation of oxygen molecules, where one or more interfaces are formed between the first material and the second material. The catalyst can be used as an alternative to the expensive palladium catalysts. In particular, the catalyst can be used for the direct synthesis of hydrogen peroxide.
    Type: Application
    Filed: March 6, 2018
    Publication date: April 18, 2019
    Inventors: Sang Soo Han, Dong Hun Kim, Seung Yong Lee, Hyo Bin Nam
  • Publication number: 20190111416
    Abstract: The present invention relates to a catalyst composition for hydroformylation and a hydroformylation method using the same, and more particularly to a catalyst composition for hydroformylation including a phosphoramidite ligand and a transition metal catalyst, and a hydroformylation method using the catalyst composition. In accordance with the present invention, provided are a catalyst composition for hydroformylation which increases productivity and provides superior catalytic activity and stability while lowering an n/i ratio in generated aldehyde upon hydroformylation of an olefinic compound, and a method of hydroformylating an olefinic compound using the catalyst composition. [Representative Figure ] FIG.
    Type: Application
    Filed: August 26, 2016
    Publication date: April 18, 2019
    Inventors: Tae Yun KIM, Sung Shik EOM, Da Won JUNG, Dong Hyun KO, Mi Young KIM, Min Ji CHOI
  • Publication number: 20190111417
    Abstract: Catalytic compositions comprising permethylpentalene based metallocene complexes supported on solid methylaluminoxane are disclosed. The compositions are effective catalysts/initiators in the polymerisation of olefins. Also disclosed are uses of the compositions in olefin polymerisation.
    Type: Application
    Filed: October 4, 2016
    Publication date: April 18, 2019
    Inventors: Dermot O'HARE, Jean-Charles BUFFET, Zoe TURNER, Duncan FRASER
  • Publication number: 20190111418
    Abstract: An acetylacetone derivative is useful for capturing a metal element by complexation. A convenient and very versatile synthesis method can be used to synthesize the derivative.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 18, 2019
    Inventors: Takashi KATO, Ken KAWATA
  • Publication number: 20190111419
    Abstract: The invention discloses a separation matrix for purification of biomacromolecules, comprising a plurality of particles (1) having a core region (2) and a shell region (3), wherein: a) said shell region is accessible to a target biomacromolecule; b) said core region is less accessible to the target biomacromolecule than the shell region; and c) the core region comprises a grafted polymer comprising residues of at least one polymerizable monomer.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 18, 2019
    Inventors: Jean-Luc Maloisel, Tobias Söderman, Ola Lind, Ida Eklind
  • Publication number: 20190111420
    Abstract: A sensor system includes an assay chamber configured to receive a fluid sample. Dispense chemistry disposed within the assay chamber. A first electrode structure includes at least one conductive element and a second electrode structure proximate to the first electrode structure is configured to transmit an electrical signal through the fluid sample. The first electrode structure is configured to receive the electrical signal transmitted through the fluid sample and responsively generate a sense signal. The sense signal being indicative of an interaction of the fluid sample with the dispense chemistry. A controller is electrically coupled to the first electrode structure and configured to identify at least one analyte in the fluid sample based on at least the sense signal generated by the first electrode structure. The first electrode structure is embedded within a base substrate and the second electrode structure is embedded within a microfluidic cap that is coupled to the base substrate.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Inventors: Joy T. Jones, Ronald B. Koo, Paul G. Schroeder, Albert Song, Sudarsan Uppili, Xiaoming Yan, Qi Luo, Sean Cahill, Henry Grage
  • Publication number: 20190111421
    Abstract: A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample.
    Type: Application
    Filed: October 19, 2018
    Publication date: April 18, 2019
    Inventor: Brandon T. Johnson
  • Publication number: 20190111422
    Abstract: The present invention is directed to a method for the preparation of a non-living micro/nanoscale biosynthetic device capable of giving an information of a state of a system to analyse. Preferably, said device is used as an assay diagnostic, or to predict the risk, of a disease, or for the classification of mammal, preferably human pathologies. The invention also relates to a method for the identification and/or the quantification of a compound in a sample. Finally the present invention includes a kit comprising the biosynthetic device obtained by the method of the present invention.
    Type: Application
    Filed: April 13, 2017
    Publication date: April 18, 2019
    Inventors: Franck MOLINA, Alexis COURBET, Francisco SANTOS SCHNEIDER
  • Publication number: 20190111423
    Abstract: Disclosed herein are devices and methods for storing, processing, preparing and/or analyzing samples. The inventions herein also relate to strategies and methods for automating device operations and for combining multiple devices in an integrated platform.
    Type: Application
    Filed: December 23, 2015
    Publication date: April 18, 2019
    Inventors: Rustem F. ISMAGILOV, Stefano BEGOLO, Jesus Rodriguez MANZANO
  • Publication number: 20190111424
    Abstract: The present invention, among other things, provides the devices and methods in manipulate a sample for the purpose of assaying.
    Type: Application
    Filed: February 9, 2018
    Publication date: April 18, 2019
    Applicant: Essenlix Corporation
    Inventors: Stephen Y. CHOU, Wei DING, Ji QI, Yufan ZHANG
  • Publication number: 20190111425
    Abstract: The disclosure relates to methods of manufacturing and using a single layer microfluidic for detecting target analytes, including obtaining a single layer sheet of paper; depositing wax boundaries onto the paper in a plurality of patterns including a main channel, fluid transfer channels, and an independent diagnostic area corresponding to each fluid transfer channel; melting the wax through the paper; depositing diagnostic components onto the diagnostic areas; depositing a continuous wax backing; and cutting devices from the paper. The disclosure also relates to a method of capturing an image of the micro fluidic device to generate diagnostic results corresponding to the diagnostic components by: identifying at least two panels from the image; and determining a color for each panel of the at least two panels; and generating for display, using the computing device, a graphical user-interface including at least one component visualizing the diagnostic results.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventor: Brianna Wronko
  • Publication number: 20190111426
    Abstract: This invention provides devices, systems, and methods for performing point-of-care, analysis, including multiplexed analysis, of a biological fluid analyte, such as blood. The invention includes a cartridge for collecting the biological fluid analyte. The cartridge is configured to be inserted into an assay reader, in which one or more assay reactions may be performed. The assay reader is designed to read and report the results of the one or more assay reactions.
    Type: Application
    Filed: October 3, 2018
    Publication date: April 18, 2019
    Inventors: Junyu Mai, Albert Gutes-Regidor, Rifat Emrah Ozel, Javier L. Prieto
  • Publication number: 20190111427
    Abstract: A microfluidic apparatus is provided that includes a thermoelectrically-activated pixel array, a microfluidic chip, and control circuitry. The pixel array may include a plurality of thermal pixels, with each thermal pixel including a thermoelectric device. The microfluidic chip may include a microfluidic channel disposed adjacent to the thermal pixels such that thermal energy generated by the thermal pixels is received by the microfluidic channel to form a localized spot within the microfluidic channel corresponding to each thermal pixel. The control circuitry may be electrically coupled to each of the thermal pixels and configured to control the thermal energy being generated by each thermal pixel to control a temperature at each localized spot within the microfluidic channel.
    Type: Application
    Filed: October 17, 2018
    Publication date: April 18, 2019
    Inventors: Konstantinos Gerasopoulos, Rama Venkatasubramanian, Mekbib Astatke
  • Publication number: 20190111428
    Abstract: The present invention provides an extraction cassette, which includes an extraction module and a liquid receiving module. The liquid receiving module communicates with the extraction module. The liquid receiving module includes a receiving module body, a sample compartment, a sealing member, an alcohol compartment and a first path. The receiving module body includes a first side, a second side and a sample feeding hole. The sample compartment is formed on the receiving module body. The sample compartment communicates with the sample feeding hole, the sample compartment includes a first sample compartment connection hole and a second sample compartment connection hole. The sealing member is adapted to seal the sample feeding hole. The alcohol compartment is formed on the receiving module body. The alcohol compartment communicates with the first sample compartment connection hole of the first sample compartment via the first path.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 18, 2019
    Inventors: Wei-Yu CHUNG, Song-Bin HUANG, Shing-Lun LIU, Yu-Kai KAO, Yi-Chen LI
  • Publication number: 20190111429
    Abstract: A fluidic device includes a first circulation flow path and a second circulation flow path which circulate a solution containing a sample material, the first circulation flow path and the second circulation flow path share at least a part of the flow path, and at least one selected from the group consisting of a capture unit which captures the sample material, a detection unit which detects the sample material, a valve, and a pump is provided on the shared flow path.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 18, 2019
    Inventors: Ryo KOBAYASHI, Keiji Mitsui, Taro Ueno, Hirofumi Shiono
  • Publication number: 20190111430
    Abstract: A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.
    Type: Application
    Filed: December 10, 2018
    Publication date: April 18, 2019
    Inventor: Lutz WEBER
  • Publication number: 20190111431
    Abstract: Methods and devices for evaluating coagulation are described, including methods and devices for detecting an anticoagulant agent or a coagulation abnormality. In various embodiments, the methods and devices of the invention measure coagulation of a sample in response to a gradient of one or more coagulation factors. These responses can be evaluated to accurately profile coagulation impairments of the sample, including the presence of anticoagulant medication. In various embodiments, the invention provides point-of-care or bedside testing with a convenient, microfluidic device that can be used by minimally trained personnel.
    Type: Application
    Filed: July 26, 2018
    Publication date: April 18, 2019
    Inventors: Galit H. Frydman, Mehmet Toner, Ronald G. Tompkins, Pavan Bendapudi
  • Publication number: 20190111432
    Abstract: The present invention relates to a method for selecting and recovering products, comprising the following steps: providing an emulsion (6) comprising a plurality of drops (4) contained in a carrier fluid (10), each drop comprising an internal fluid (8), measuring at least one physical parameter for several drops (4) of the emulsion (6), classifying at least some of the drops (4) of the emulsion in a class based on measurements obtained during the measuring step, tagging at least some of the classified drops (4) based on the class of the drop (4), selectively recovering the drop (4) or part of the drop (4) using the tag of the drop or part of the drop (4).
    Type: Application
    Filed: April 14, 2017
    Publication date: April 18, 2019
    Inventors: Jean BAUDRY, Jérôme BIBETTE, Laurent BOITARD, Klaus EYER, Krzysztof LANGER
  • Publication number: 20190111433
    Abstract: An active matrix electrowetting on dielectric (AM-EWoD) device including dual substrates with thin-film transistors (TFT) and capacitive sensing. As depicted herein the bottom substrate includes a first plurality of electrodes to propel various droplets through a microfluidic region, while the top substrate includes a second plurality of electrodes that are configured to interrogate the droplets with capacitive sensing. In some embodiments, the top substrate has zones of high-resolution sensing and zones of low-resolution sensing.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventor: Ian FRENCH
  • Publication number: 20190111434
    Abstract: Systems, devices and methods are disclosed for collecting laboratory specimens from laboratory specimen boxes once a specimen has been placed inside a box.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Mike Eller, Ross Schneidman, Chris Zavala, Brian Torpey
  • Publication number: 20190111435
    Abstract: An apparatus for thermally processing reaction material containing nucleic acid is provided. A reaction material is contained in reactors. The apparatus includes a reactor holder for statically holding the reactors; at least two heating means each being maintainable at a user specifiable temperature; and a transport means for positioning the heating means to make a contact with the reactors one at a time for specified duration. The positioning is conductable once or over a plurality of times for thermally processing the reactors between a plurality of temperatures.
    Type: Application
    Filed: December 10, 2018
    Publication date: April 18, 2019
    Applicant: STAR ARRAY PTE LTD
    Inventors: Haiqing GONG, Yan WEN, Xudong ZENG
  • Publication number: 20190111436
    Abstract: A diagnostic assay system includes a platform configured to receive a disposable cartridge having a sample chamber for receipt of an assay fluid, and an a PCR chamber disposed in fluid communication with the sample chamber for performing target amplification of the assay fluid. A heating source is disposed adjacent a heat exchange surface disposed along at least one side of the PCR chamber and is configured to conform to the contour of the heat exchange surface to accelerate target amplification of the assay fluid. The heating source introduces heat into the assay fluid from one side of the disposable cartridge and, in one embodiment, employs a conformal material interposing the heating source and the heat exchange surface to mitigate the formation of air pockets therebetween.
    Type: Application
    Filed: November 30, 2018
    Publication date: April 18, 2019
    Applicant: Integrated Nano-Technologies, Inc.
    Inventors: Nathaniel E. Wescott, Dennis M. Connolly, Richard S. Murante, Mark J. Smith
  • Publication number: 20190111437
    Abstract: The invention relates to a holder, in particular a cleaning device, for receiving at least one preferably elongate sample container, in particular a cuvette, which has an opening and a bottom opposite the opening in a longitudinal direction and closing the sample container, for cleaning such a sample container, wherein the holder is provided with a first element for at least partially abutting in the longitudinal direction against an edge of the opening of the sample container, the edge facing towards the longitudinal direction, wherein the first element has a passage which is configured in such a way that it at least partially overlaps with the opening of the sample container when the sample container is received, and which is configured, when the sample container is received, to introduce and discharge fluid through the opening for cleaning the sample container, and has a second element, which is essentially opposite the first element in the longitudinal direction, for at least partially abutting in the lon
    Type: Application
    Filed: April 24, 2017
    Publication date: April 18, 2019
    Applicants: Baxalta Incorporated, Baxalta GmbH
    Inventors: Gabriela PRODINGER, Martin PILLIATER