Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.

Abstract: An aptamer-mRNA conjugate is provided. The aptamer-mRNA conjugate may include an aptamer component that binds a membrane associated protein on a target cell and an mRNA component that is expressed by the target cell.

Abstract: A system for sanitizing a tray table may include a sanitation assembly operatively coupled to the tray table. The sanitation assembly includes an ultraviolet (UV) light source configured to emit UV light, and a sanitation control unit operatively coupled to the UV light source. The sanitation control unit operates the UV light source to emit the UV light onto the tray table when the tray table is secured in an upright position, and prevents the UV light source from emitting the UV light when the tray table is not secured in the upright position.

Abstract: The present disclosure relates generally to systems, devices and methods for disinfection of space and equipment. In particular, the present disclosure relates to systems, devices and methods, such as rolling enclosures, which use light sources, such as ultraviolet (UV) light, and more specifically UV-C light, to disinfect larger scale equipment or spaces. Systems and methods of the present disclosure are particularly useful in medical facilities for treating medical equipment or spaces, where the prevalence of pathogens requires frequent disinfecting.

Abstract: Ultraviolet radiation is directed within a storage area at target wavelengths, target intensities, a target temporal distribution, and/or a target spatial distribution. A set of ultraviolet radiation sources generate ultraviolet radiation directed at a set of items located within the storage area. A first ultraviolet radiation source operates at a first peak wavelength and a second ultraviolet radiation source operates at a second peak wavelength that is different from the first peak wavelength.

Abstract: A system and method of sanitizing one or more structures within an enclosed space includes operatively coupling an ozone ventilation control unit to an ultraviolet (UV) light assembly, an ozone sensor, and an exhaust fan, using the ozone ventilation control unit to operate the UV light assembly to emit UV light into or onto structure(s) of the enclosed space during a cleaning cycle, receiving, by the ozone ventilation control unit, an ozone presence signal indicative of an amount of ozone within the enclosed space from an ozone sensor that detects the amount of ozone within the enclosed space, using the ozone ventilation control unit to selectively activate and deactivate the exhaust fan based on the amount of ozone within the enclosed space, and using the ozone ventilation control unit to selectively activate and deactivate the UV light assembly based on the amount of ozone within the enclosed space.

Abstract: There is provided an aerosol generating device, including a vaporizer for heating an aerosol-forming substrate to form an aerosol; a plurality of air flow nozzles; and at least one air outlet. The air flow nozzles and the air outlet are arranged to define an air flow route between the air flow nozzles and the air outlet. Each of the air flow nozzles includes an aperture arranged to direct air towards the vicinity of the vaporizer in a direction across the surface of the vaporizer so as to manage particle size in the aerosol.

Abstract: A portable electronic device with a smart air purifier is provided with an electronic device body having a display surface, a back surface and a side jointed with the surfaces. The smart air purifier is embedded in the electronic device body. The smart air purifier includes a container, a fan, an air cleaning device, an air quality receiver, a tracking device, an adjustable opening, and a control panel. The container includes an air inlet formed on the back surface, an air outlet formed on the display surface, and an opening formed on the side. The fan draws air from the inlet to provide an airflow. The air cleaning device filters the airflow. The air quality receiver detects quality of the airflow. The tracking device tracks the user. The adjustable opening is disposed at the air outlet of the container. The control panel controls the fan and the adjustable opening.

Abstract: A multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic. The multifunctional polymer-free clay product provides antimicrobial and pain relieving properties. Method of treatment of burns using the multifunctional polymer-free clay product having antimicrobial and pain relieving properties. Methods of preparing multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic.

Abstract: A target tissue can be treated with a radioisotope. Some methods for treating a target tissue with a radioisotope include determining a distance between a target tissue and a surface of a matrix material to be positioned adjacent the target tissue and, based on the determined distance, determining an activity to be mixed with the matrix material to obtain a desired activity concentration. Some methods further include mixing the radioisotope with the matrix material. In some embodiments, the matrix material comprises bone cement, and the target tissue is a tumor in a bone. The radioisotope may be a beta-emitting radioisotope mixed in the cement at a concentration to form a radioactive cement.

Abstract: A bone cement comprising an acrylic polymer mixture which is formulated to have a relatively high viscosity for a relatively long window, due to distributions of molecular weights and/or sizes of acrylic beads.

Abstract: There is provided a composition comprising covalently linked segments of for example, polycaprolactone and polyethylene glycol that are linked by a cross-linker. Such a composition foams in the presence of a catalyst and a solution containing an oxygen forming chemical like hydrogen peroxide. The foamed composition retains oxygen for delivery to, for example, a wound, where it aids in healing.

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.

Abstract: Joint resurfacing and/or replacement devices, systems and methods that include thin film ternary ceramic coatings that are effective to provide reliable articulation and bearing surfaces and protection of both articular and modular junction surfaces from the potential for corrosion, wear, and fretting, and reduce the potential for release of metal ions from the joint systems. Isoelasticity is provided according to the particular joint resurfacing/replacement devices, systems and methods based on parameters that include material of construction, porosity and coating system. The thin film ternary ceramic coatings may be functionalized to enhance hydrophilicity and may be employed in any anatomical articulating joint region. Titanium alloy composite structures are provided that include an ultra-porous structured titanium alloy bone fixation surface and an opposed solid articular surface and a thin film ternary ceramic coating applied to one or both opposed surfaces.

Abstract: The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: The present invention relates to a perforated semi-permeable device comprising, human pancreatic endocrine cells or human PDX1-positive pancreatic endoderm cells contained within a semi-permeable membrane comprising a synthetic material, wherein the synthetic material is polysulfone (PSF), nano-fiber mats, polyimide, tetrafluoroethylene/polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyacrylonitrile, polyethersulfone, acrylic resin, cellulose acetate, cellulose nitrate, polyamide, or hydroxylpropyl methyl cellulose (HPMC), a cell encapsulation chamber, and at least one seal that is within the cell encapsulation chamber.

Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

Abstract: The object of the present invention is a method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine hydrochloride and an alkaline agent, sterilized with heat, having hyaluronic acid concentration and flow properties, equivalent to those of the corresponding hydrogel based on hyaluronic acid not containing any lidocaine hydrochloride. The present invention also relates to various uses of the aforementioned hydrogel.

Abstract: Described herein is a porous copolymer membrane composed of poly(styrene sulfonate)-block-polyethylene-block-poly(styrenesulfonate) for use in the absorption of doxorubicin, and a chemofiltration catheter incorporating the membrane for use in transarterial chemoembolization.

Abstract: The present invention relates to an implant, in particular an intraluminal endoprothesis, comprising a body containing a metallic material, and comprising at least one functional element that is fastened to the body and has a material composition in at least a portion of its volume that differs from the material of the body, the material composition preferably including radio-opaque and/or x-ray opaque material. To effectively prevent accelerated degradation due to the formation of a local cell of the material of the body and the functional element, the at least one functional element includes a first layer at least in the region of its surface where it is bonded to the body, the first layer primarily containing at least one metal oxide. Furthermore, the manufacture of an implant of this type is described.

Abstract: A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier.

Abstract: A centrifugal pump for pumping blood in a circulatory support system has an inlet port configured to prevent or reduce formation of a thrombus in the blood. The centrifugal pump includes a housing with a main body, inlet and outlet ports, an impeller, and a support mechanism for the impeller. The support mechanism has a rod-like shaft member, and first and second bearings which rotatably support end portions of the shaft member. A lower surface of the first bearing is positioned at a distance from an inner peripheral surface of the blood inlet port from a central axis of the blood inlet port which is equal to or less than a distance from the central axis to the inner peripheral surface of the blood inlet port.

Abstract: A ventricular assist system includes a ventricular assist device (“VAD”) and an expandable stent. The VAD may include a pump and an inlet element defining an inlet opening communicating with the pump, the inlet element being adapted for positioning with the inlet opening disposed within a ventricle of a heart when the system is in an operative condition. The expandable stent may be adapted for positioning within the ventricle when the system is in the operative condition. The pump may be operated to draw blood from the ventricle and return the blood to the artery, and a wall of the ventricle may be held away from the inlet opening with the stent. The stent may be passed through a channel in the ventricular assist device while the stent is in a collapsed condition.

Abstract: Embodiments of the disclosure include a method and system for estimating flow rates of a fluid or medium though a dialyzer during a dialysis treatment (e.g., a hemodialysis treatment). Pressure sensors are incorporated in dialyzers used for hemodialysis to achieve continuous monitoring of fluid balance of the body. During dialysis, obtaining fluid input and output pressures experienced at various inlets and outlets of dialyzers is easier than obtaining flow rates at these inlets and outlets, but using flow rates is better in determining the effectiveness of a dialyzer during hemodialysis. Embodiments of the disclosure thus use pressure measurements at inlets and outlets of a dialyzer along with a dialyzer model to determine fluid flow rates through the dialyzer. The fluid flow rates are used to determine whether there are leakages or occlusions in tubing during the dialysis treatment.

Abstract: Provided, among other things, is a method of treating cerebral spinal fluid comprising: (a) utilizing a channel of a pump to draw CSF from a subject's subarachnoid space of the subject's brain or spinal column; (b) subjecting the drawn CSF to membrane dialysis against a dialysate fluid to reduce immune or inflammatory mediators; and (c) utilizing a second channel of the synchronized dual channel pump to return the dialyzed CSF to the subarachnoid space of the subject's brain or spinal column. For example, the pump can be a synchronized dual channel pump. In one embodiment, the method further comprises: (d) removing cellular matter from the CSF to produce reduced cell content CSF, wherein the reduced cell content CSF is subjected to membrane dialysis.

Abstract: A dialysis system comprising: a sorbent cartridge including a zirconium phosphate layer followed by at least one of a urease layer, a zirconium oxide layer, or a carbon layer; a pump in fluid communication sorbent cartridge; and a control unit in operable communication with the pump, wherein the control unit is programmed to cause the pump to pump a dialysis fluid to flow (i) in a first direction through the sorbent cartridge, wherein the zirconium phosphate layer is contacted by the dialysis fluid before the at least one of the urease layer, zirconium oxide layer or carbon layer and (ii) in a second direction through the sorbent cartridge wherein the at least one of the urease layer, zirconium oxide layer or carbon layer is contacted by the dialysis fluid before the zirconium phosphate layer.

Abstract: An example renal therapy system includes a blood pressure monitor configured to output blood pressure data concerning a patient and a renal therapy machine communicatively coupled to the blood pressure monitor. The renal therapy machine is configured to generate ultrafiltration (“UF”) removed data from a prescribed renal therapy treatment performed by the renal therapy machine on the patient, and transmit the UF removed data and the blood pressure data via a network. At least one of a UF trend or a blood pressure trend from the UF removed data or the blood pressure data is determined, enabling a further determination as to at least one of (a) whether a prescribed renal therapy treatment adjustment or a new prescribed renal therapy treatment needs to be made, (b) whether the patient is complying with the prescribed renal therapy treatment, or (c) whether a condition related to an alarm or an alert exists.

Abstract: The present invention provides a filter for separating particles and/or catalyzer for particle reaction in a fluid. The device comprising array of passageways fabricated on a die wherein the passageway size is controlled by actuators. The passageway size is monitored and the actuators controlling the passageway size are activated conditionally upon the passageway size monitoring. Using movable actuators the passageway can achieve passageway size that is less then the fabrication minimal resolution. Proper locating, setting and/or activation of the actuators create passageways that can perform filtration of particles, trapping of particles and catalyzing particles reaction.

Abstract: A drug delivery device is provided for directly treating a treatment site. The device allows body fluids to perfuse past the device while it is expanded to increase the amount of treatment time that is possible. The drug is delivered through a hollow helical tube that extends around a support structure. The hollow tube includes a series of lateral holes to allow the drug to directly reach the desired treatment site.

Abstract: Provided herein are devices for concurrent intravenous infusion of multiple drugs. The device comprises a body with a syringe holding portion and a syringe driving portion, two or more syringes secured therein and a multi-lumen catheter with a plurality of inlet channels and a single outlet channel. Also provided is a method for treating acute myocardial infarction complicated by advanced acute heart failure in a patient. Two or more drugs, such as a beta-blocker and a positive inotropic agent, in prefilled syringes are secured in the device and administered simultaneously into a single vein in a patient without the drugs mixing prior to administration. In addition, a kit is provided that comprises the device and syringes prefilled with a beta-blocker and the positive inotropic agent.

Abstract: A pressure solution of an infusion solution holder has a collar that is ergonomically fitted to the shape of the shoulders. The collar includes a pressure tank integrally with the holder and a tank containing the infusion solution. Since the tank containing the infusion solution is located on the patient's shoulders and vertically close to the supply point of the infusion solution, there has to be sufficient pressure in the tank in order for a successful infusion. Therefore, the collar's pressure tank is pressurized by the element, whereby the pressure in the pressure tank is pressing the solution tank and creates the necessary pressure at the time of infusion. The pressurization of the pressure tank is shown in the most cost-effective way by pumping with a manual pressure element, such as a ball pump. Pressurization can also be made, for example, by an electric pump.

Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

Abstract: Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods.

Abstract: A therapeutic product delivery device is described, which comprises a circuit layer, an actuator layer carrying an actuator, an occlusion detection layer (118), and a valve layer, through which a therapeutic product is conveyed by the action of the actuator. A plurality of conductive pins (155) extend from the circuit layer through or to each of the actuator layer, the occlusion detection layer and the valve layer, the conductive pins aligning the layers with each other. The occlusion detection layer comprises a plurality of contacts, each electrically connected to a respective one of the conductive pins, the contacts being provided at a detection region at which the therapeutic product is deposited in the event of a blockage. A blockage inhibiting the therapeutic product from being conveyed to the patient is detected when therapeutic product deposited in the detection region provides an electrical connection between the contacts.

Abstract: A system for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range.

Abstract: Delivery of more than one therapeutic fluid as a means to control symptoms of a health conditions is disclosed. More than one therapeutic fluid may be dispensed from more than one reservoir and delivered to a user's body via one or more cannula that penetrate the skin. The therapeutic fluids may be delivered by action of one or more pumping mechanisms that may be controlled by a processor in a portable, ambulatory device. The therapeutic fluids may optionally be insulin and one or more of an amylin analog, pramlintide acetate and an exenatide, and the health condition may optionally be diabetes. This device can be used in combination with a glucometer.

Abstract: A communication method of managing communications to and from a handset device controlling a therapeutic product delivery device is described. The method comprises transmitting, to a server, at least part of a unique identifier for a handset device for controlling a therapeutic product delivery device, and patient information regarding a user to be associated with the handset device, and at the server, associating the handset device with the patient information, generating a handset specific code, and transmitting the handset specific code to the user. At the handset device, a manual input of the handset specific code is received, and the future transmission of data from the handset device to the server carried out in association with the handset specific code.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device involves obtaining one or more measurement values of a physiological condition in the body of a user during an initial monitoring period and determining a fasting reference value for a metric based on the one or more measurement values. After the initial monitoring period, the method continues by obtaining an updated measurement value during a fasting period, determining a current value for the metric based at least in part on the updated measurement value, and generating a notification in response to a deviation between the current value and the fasting reference value exceeding a threshold indicative of insertion site loss or other loss of effectiveness.

Abstract: Described is an injection device for administering a dose of a medicament (M) comprising a carrier adapted to contain a syringe having a hollow injection needle and a stopper, a drive spring, a plunger adapted to forward load of the drive spring to the stopper, and a noise component adapted to generate an audible and/or tactile feedback by impacting a component of the injection device when the stopper is located at a proximal end of the syringe. In a first state, a resilient arm on the plunger is maintained in engagement with the noise component by the carrier. In a second state, the arm disengages the noise component and deflects at least partially into an aperture in the carrier.

Abstract: A device for injection of a medicament includes a housing having distal and proximal end openings; a needle guard extending from the proximal end opening and movable relative to the housing from an extended position to a retracted position, in which the needle guard is biased toward the extended position; an activation member extending from the distal end opening and movable relative to the housing from an initial position to a final position; a lock that restricts movement of the activation member in the final position; and a needle guard lock that restricts movement of the needle guard from the extended position to the retracted position when the activation member is in the final position. A method of assembling the medicament delivery device is also disclosed.

Abstract: The present invention is directed to a drug delivery device comprising a cartridge with a movable bung, a drive mechanism including a bearing for driving the bung in a distal direction for delivering a medicament and a piston rod for actuating the bearing. An electric conductor for transmitting an electrical signal is provided, wherein the electric conductor is configured such that a conductive connection is established or interrupted when the piston rod contacts the bearing or when the bearing contacts the bung. The invention is further directed to a method for detecting the contact between the drive mechanism and the movable bung.

Abstract: A dose setting mechanism for a medicament delivery device is presented having a pinion mounted to a locking member where the axis of rotation of the pinion is offset and parallel to the longitudinal axis of the housing containing the dose setting components. Primary and secondary dose members are engaged with the pinion to indicate a set dose of medicament.

Abstract: The present invention provides a sterile solution comprising leuprolide acetate in a pharmaceutically acceptable vehicle, wherein solution is present as a reservoir in a multiple dose pen injection device, the device being adapted to subcutaneously inject a portion of the said reservoir in a single daily dose and further being adapted to provide multiple portions of solution said while the reservoir remains sterile.

Abstract: A front cap for a medicament delivery device having proximal and distal ends is configured to be releasably connected to the medicament delivery device and includes a shield grabber support and a shield grabber for connecting the front cap to an outer surface of a needle shield of a syringe positioned within the medicament delivery device. The shield grabber is coupled to the shield grabber support such that the shield grabber is axially movable relative to the shield grabber support.

Abstract: A permeation apparatus comprises an aspiration tube; an injection tube; and a water-absorbing cover member for covering at least a distal end of the injection tube and a vicinity of the distal end. The aspiration tube is configured to aspirate a fluid flowing from the water-absorbing cover member into the aspiration tube.

Abstract: The present disclosure describes anti-needle stick safety mechanism that is passively activated during the normal course of giving an injection. In one embodiment, the device includes a spring member coupled at a proximal end to a needle member and at a distal end to a needle cover. The passive activation of the device is triggered when the needle is inserted to a minimum depth into the patient's tissue to unleash the force of a compressed spring to urge a needle cover towards the distal end of the needle. As the needle is withdrawn from the tissue, the needle cover advances to the end of the needle and as it partially clears the end of the needle, it adopts an orientation that prevents the needle tip from re-emerging from the needle cover.

Abstract: An injection device has a housing which includes a first housing part and a second housing part. The injection device has a receptacle for an injection needle. The receptacle is connected to a drive unit which moves the receptacle between proximal and distal end positions relative to the second housing part. The first housing part has a set piece for placing on the skin before triggering an injection. The first housing part is permanently fastened with respect to the second housing part. In a method for making the injection device, the first housing part is positioned on the second housing part so that the receptacle has a specified position relative to the set piece in the proximal end position thereof, and that the first housing part is permanently fastened in this position opposite the second housing part. A defined insertion depth can thus be ensured.

Abstract: The present invention relates generally to a warming apparatus such as but not limited to a sleeve with an attached tourniquet that allows for a method of warming human body parts and a method to induce vasodilation to produce the ease of venipuncture. The invention preferably induces vasodilation by applying heat to an area and then further where venipuncture or intravenous catheter insertion is desired, preferably constricting and compressing the veins by bringing them to the surface with the tourniquet.

Abstract: A syringe includes a syringe outer tube including: a tubular-shaped outer tube main body, a reduced diameter section projecting from a distal end of the outer tube main body, and having a distal end opening that is configured to discharge the liquid from the outer tube main body through the reduced diameter section, and a lock adapter concentrically disposed at an outer circumferential portion of the reduced diameter section and configured to be fixed to a mating member; and a cap mounted on the syringe outer tube and including: a cap main body sealing the reduced diameter section in a liquid-tight manner, the cap main body comprising: a base portion including an opening, and a projection projecting into the opening, and a sealing member disposed in the opening, wherein the projection of the base portion contacts a distal end surface of the sealing member.

Abstract: Fluid delivery device for discharging a fluid, having: a housing; piston pump; biasing mechanism; and trigger mechanism. The housing has a basal end and a discharge end with outlet for discharging the fluid. The piston pump has a casing defining a pump chamber for storage of fluid, a piston slidably movable relative to the pump chamber, a piston plunger, and a delivery channel. The trigger mechanism is movable from a cocked configuration wherein the trigger mechanism prevents transfer of a biasing force of the biasing mechanism to the casing to a triggered configuration with the trigger mechanism enabling transfer of the biasing force to the casing to cause movement of the casing towards the housing outlet to discharge fluid from the pump chamber, along the delivery channel and out of the outlet of the housing. The biasing mechanism has one or more flexible catch members and a manually operable trigger.