Patents Issued in May 2, 2019
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Publication number: 20190125918Abstract: Freezer for biosanitary and cytotoxic waste, which comprises an inner space that houses a waste container, a front door through which the waste container in the inner space is inserted/removed, an upper door through which waste is poured into the inner container, cooling means and inner space temperature control means, wherein, the freezer further comprises an air purifier that treats an air stream coming from the inner space, when opening one of its doors, thus avoiding the emission of both chemical and biological particulate contaminants to the outside environment.Type: ApplicationFiled: April 29, 2016Publication date: May 2, 2019Inventor: Eduardo Toro Casasnovas
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Publication number: 20190125919Abstract: In some embodiments, a system for purifying an environment may be provided. The system may include a first electrode which may be exposed to air. The system may include a first transducer which may be configured to apply a first energy to the first electrode and a second transducer which may be configured to apply a second energy to the first electrode. The system may be configured such that at a first time, the first transducer applies the first energy to the first electrode and the second transducer does not apply the second energy to the first electrode. The system may be further configured such that at a second time, the second transducer applies the second energy to the first electrode.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Applicant: RGF ENVIRONMENTAL GROUP, INC.Inventors: Walter B. ELLIS, Ronald G. FINK
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Publication number: 20190125920Abstract: Disclosed herein are apparatuses and methods for generating non-thermal plasma which can form reactive oxygen species (ROS), such as those used to neutralize bacteria and other pathogens in the air and surrounding area. Also disclosed are apparatuses and methods for neutralizing bacteria and other pathogens using ROS generated through the use of non-thermal plasma. Also disclosed are apparatuses and methods for generating ROS. Also disclosed are apparatuses and methods for treating air and nearby surfaces.Type: ApplicationFiled: October 29, 2018Publication date: May 2, 2019Inventor: Terrance Woodbridge
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Publication number: 20190125921Abstract: Provided is a water-absorbing agent having an excellent ability to absorb and retain liquid and an excellent liquid suction power. The water-absorbing agent contains a polyacrylic acid (salt)-based water-absorbing resin as a main component and satisfies all of the following physical properties (a) to (e): (a) a weight average particle diameter (D50) is 300 ?m or more and less than 400 ?m; (b) a proportion of particles with a particle diameter of 600 ?m or more and less than 850 ?m is less than 10 weight %; (c) an average gap radius is 100 ?m or more and less than 180 ?m; (d) a CRC is 28 g/g or more and less than 34 g/g; and (e) an AAP is 24 g/g or more.Type: ApplicationFiled: March 28, 2017Publication date: May 2, 2019Applicant: NIPPON SHOKUBAI CO., LTD.Inventors: Kazuki KIMURA, Nobuya TANAKA, Yuki TANAKA, Daisuke TAKEDA
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Publication number: 20190125922Abstract: A process of preparing an adhesive haemostatic product is provided. The process comprises: (a) coating a porous solid substrate with a coating liquid that comprises an electrophilically activated polyoxazoline (EL-POX) and a solvent to produce a coated substrate; and (b) removing the solvent from the coated substrate. The EL-POX comprises at least 2 reactive electrophilic groups. The process enables the application of an EL-POX coating that leaves the pore structure of the substrate largely intact so that the ability of the porous substrate to absorb body fluids, such as blood, remains essentially unaffected. The EL-POX coated haemostatic product obtained by the present process has excellent adhesive properties due to the presence of electrophilic reactive groups that are capable of reacting with e.g. amine groups that are naturally present in tissue, under the formation of covalent bonds.Type: ApplicationFiled: December 19, 2018Publication date: May 2, 2019Applicant: GATT Technologies B.V.Inventors: Johannes Caspar Mathias Elizabeth BENDER, Marcel Alexander BOERMAN
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Publication number: 20190125923Abstract: The present disclosure is directed to a naniofiber comprising a jellyfish extract and at least one non-jellyfish-derived electrospinnable polymer. The jellyfish extract may comprise an alcohol extract of jellyfish biomass. The jellyfish extract may comprise comprise Q-mucin. Methods of producing the nanofiber are also disclosed.Type: ApplicationFiled: April 10, 2017Publication date: May 2, 2019Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Shachar RICHTER, Roman NUDELMAN, Tamilla GULAKHMEDOVA
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Publication number: 20190125924Abstract: This invention relates to a multi-layer wound site dressing specifically designed to treat chronic wounds and simultaneously block external pathogens from infecting the wound site from the environment. The said wound dressing comprises five layers; each layer performs a specific functionality in healing and protecting the wound site. The said layers of wound care dressing comprise (i) a permeable non-adherent woven or non-woven membrane in contact with wound site, (ii) a nanofibrous composite layer made of superabsorbent, activated carbon and a polymer (iii) a hydrophobic insulating membrane which is permeable to air with an adhesive edge, (iv) a nanofibrous membrane made of polymer and activated carbon hosting functional germicidal ions, and (v) an air permeable non-woven membrane with adhesive edge. The said layers are compounded by pressing and coating to make a comprehensive multi-layer wound care dressing product.Type: ApplicationFiled: October 31, 2018Publication date: May 2, 2019Applicant: InMEDBio, LLCInventors: Ashwinraj Karthikeyan, Annamalai Karthikeyan
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Publication number: 20190125925Abstract: A fibrin sealant product having a plurality of layers that each includes a dextran support and at least one fibrin sealant agent. The at least one fibrin sealant agent is placed on the dextran support to form each of the layers. The plurality of layers is placed in a stacked configuration to form the fibrin sealant product. A plurality of crimps is dispersed over a surface of the fibrin sealant product to retain the plurality of layers in a position with respect to each other.Type: ApplicationFiled: October 31, 2018Publication date: May 2, 2019Inventors: Rudy Padua, Philip Messina
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Publication number: 20190125926Abstract: Novel compositions for treating wounds and promoting the healing thereof are described, including composition containing novel combinations of a carrier and recombinant platelet derived grown factor having fewer isoforms and enhanced biostability. Methods of treating wounds with novel therapeutic composition using dosing procedures leading to effective results with a minimal number of treatment applications are also described.Type: ApplicationFiled: July 25, 2018Publication date: May 2, 2019Inventors: Sameul E. Lynch, Leslie Wisner-Lynch
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Publication number: 20190125927Abstract: Methods, systems, apparatuses and devices for implantation in a soft-tissue biological environment that include a primary layer for containing a filler substance, an interface and a secondary layer, including embodiments where the secondary layer an ePTFE layer, the primary layer is a silicone layer, the interface is mechanical or adhesive and the tiller substance can include particulates and lattices.Type: ApplicationFiled: April 26, 2018Publication date: May 2, 2019Inventor: Mark A. Anton
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Publication number: 20190125928Abstract: The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.Type: ApplicationFiled: May 16, 2018Publication date: May 2, 2019Inventors: David B. Masters, Eric P. Berg
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Publication number: 20190125929Abstract: The present invention relates to novel compositions and methods for reducing or eliminating the thrombogenicity of a graft by modifying the graft with a cell-derived extracellular matrix lacking thrombospondin-2 (TSP2-null ECM) to render it non-thrombogenic when transplanted to a subject in need thereof. The invention also provides a method for improving the biocompatibility of a medical device or an implant by modifying the medical device or implant with a cell-derived TSP2-null ECM, whereby the medical device or implant is rendered non-thrombogenic and pro-migratory.Type: ApplicationFiled: April 25, 2017Publication date: May 2, 2019Inventors: Themis KYRIAKIDES, Nina KRISTOFIK
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Publication number: 20190125930Abstract: Disclosed herein is a method of producing a decellularized bioscaffold from an organ or a vessel covered by a lining tissue. The method comprises subjecting the organ or the vessel to a digestion buffer thereby removing the lining tissue from the tissue or organ; and then treating the tissue or organ with a decellularization buffer. The present decellularized bioscaffold is useful in promoting tissue regeneration and/or remodeling.Type: ApplicationFiled: October 26, 2017Publication date: May 2, 2019Applicant: NATIONAL CHENG KUNG UNIVERSITYInventors: Ho-Yi TUAN-MU, Yi-Hao CHANG, Jin-Jia HU
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Publication number: 20190125931Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.Type: ApplicationFiled: December 20, 2018Publication date: May 2, 2019Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
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Publication number: 20190125932Abstract: Described is a device for preventing thrombosis formation on surfaces of a blood contact device. The device may first non-invasively scan the blood contact device and determines the highest risk thrombosis points. The device then, preferably starting with the highest risk location, delivers a succession of harmonic vibration signals or electromagnetic signals non-invasively so as to prevent clot formation at each stagnation high risk point of the blood contact device (e.g., harmonic resonance). This resonant vibration calibration tuning information is stored in an associated microprocessor. The signals are then delivered, based upon the stored information, in a loop from the signal generator, usually on a belt outside the patient, to each stagnation point in sequence from highest risk of thrombosis to lowest; again and again repeated.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Inventors: Howard J. Leonhardt, Jeff Donofrio
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Publication number: 20190125933Abstract: Methods, systems, and kits provide robust and biologically active coatings for implanted medical devices. The methods are based on electrostatic attraction between a conductive or non-conductive material surface on the medical device and a coating material including a charged biopolymer or pharmaceutical agent. Surface charge is induced or enhanced in the conductive or non-conductive material using a physical method. The methods are applicable to a wide variety of conductive or non-conductive substrate materials and coatings containing any of a wide variety of biological molecules and pharmaceutical agents.Type: ApplicationFiled: May 13, 2016Publication date: May 2, 2019Inventors: Garima BHARDWAJ, Thomas J. WEBSTER
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Publication number: 20190125934Abstract: Hydrogel-substrate laminate structures and tough biocompatible hydrogel coatings for various equipment such as medical devices and underwater equipment, in which robust interfaces are formed between the hydrogel coatings and the substrate/equipment surface(s). The hydrogel coatings provide a highly-hydrated, ultra-low friction structure that does not rupture or delaminate under stress. The hydrogel coatings may further incorporate a variety of therapeutic agents and/or sensing mechanisms to provide for environmental sensing and therapeutic agent release.Type: ApplicationFiled: October 26, 2017Publication date: May 2, 2019Inventors: Xuanhe Zhao, German Alberto Parada Hernandez, Hyunwoo Yuk
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Publication number: 20190125935Abstract: Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.Type: ApplicationFiled: June 28, 2018Publication date: May 2, 2019Inventors: Donald J. EATON, Bin HUANG, Anthony J. ABBATE, Gail M. ZALER, David C. GALE
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Publication number: 20190125936Abstract: A mesh-based composition comprising a cross-linkable protein or polypeptide and one or more cross-linking materials according to at least some embodiments.Type: ApplicationFiled: May 9, 2017Publication date: May 2, 2019Inventors: Orahn PREISS-BLOOM, Guy TOMER, Amir HADID, Alon POLAKEWICZ, Ariel MAIZLER, Denis KRAMARENKO, Daniella GODER, Danny YOSUFOV
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Publication number: 20190125937Abstract: A method includes spreading a solution including a polyether and a photoinitiator onto a hydrophilic porous membrane, impregnating hydrophilic the porous membrane with the solution, and curing the solution located within the hydrophilic porous membrane by exposure to ultraviolet light to produce a composite membrane.Type: ApplicationFiled: April 4, 2017Publication date: May 2, 2019Inventors: Avi Rotem, Baruch Zimmerman, Uriel Barkai, Shiri Maimon
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Publication number: 20190125938Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: ApplicationFiled: April 26, 2018Publication date: May 2, 2019Applicant: TYRX, Inc.Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich
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Publication number: 20190125939Abstract: Medical grade yarns, medical devices constructed of such yarns, and methods for making such yarns and devices are described. Polyester drawn fibers, and more particularly high strength and high tenacity micro polyester fibers for use in medical devices, and methods of preparing the same are provided.Type: ApplicationFiled: August 3, 2018Publication date: May 2, 2019Applicant: Rx Fiber, LLCInventor: Brenda Gilchrist
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Publication number: 20190125940Abstract: In an embodiment, a stent (S) implantable in a vessel of a patient, comprises recesses (200) loaded with an active principle with anti-inflammatory activity (10) and an active principle with anti-proliferative activity (20). The active principle with anti-inflammatory activity (10) and the active principle with anti-proliferative activity (20) have respective formulations, whereby the active principle with anti-inflammatory activity (10)and the active principle with anti-proliferative activity (20) have respective release kinetics as a function of said formulations, with the release of the active principle with anti-inflammatory activity (10) being faster than the release of the active principle with anti-proliferative activity (20).Type: ApplicationFiled: March 28, 2017Publication date: May 2, 2019Inventors: Ilaria Zambaldi, Franco Vallana, Matteo Antoniotti, Andrea Grignani
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Publication number: 20190125941Abstract: Disclosed herein are devices, systems, and methods for accurately tracking the amount of flushing liquid delivered to a patient. The disclosed systems monitor the usage of flushing liquid during an operation using a flow sensor or flow probe. The disclosed systems use a flow sensor to measure the flow rate of liquid through a conduit. Using the flow-related data, a processor can calculate the amount of flushing liquid used. This information can be displayed and/or provided to a fluid monitoring system. With this information, together with the total volume of effusion liquid in a collection container, the disclosed systems can accurately determine how much blood is lost from the patient.Type: ApplicationFiled: October 24, 2018Publication date: May 2, 2019Inventors: Peiyuan Li, Geertruida Lucretia van der Sar
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Publication number: 20190125942Abstract: In one example embodiment, a system for stimulating healing of tissue at a wound site is disclosed. The system comprises a dressing including a porous pad and a drape covering the pad at a wound site for maintaining negative pressure at a wound site, a negative-pressure source including a pump and an electric motor to generate a pump pressure (PP) for applying to the wound site, and a first pressure sensor for sensing the pump pressure (PP). The system further comprises a controller coupled to the first pressure sensor and electric motor and including a PID controller that compares the pump pressure (PP) to a target pump pressure (TPP) and a bang-bang controller that controls wound pressure (WP) proximate the wound site, and wherein the controller is configured to alternatively select the bang-bang controller when the system is in a low-leakage condition or the PID controller when the system is in a high-leakage condition.Type: ApplicationFiled: October 12, 2018Publication date: May 2, 2019Inventors: Loren FRANCIS, JR., Reuben W. EDGAR, JR.
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Publication number: 20190125943Abstract: Embodiments of negative pressure wound therapy systems and methods are disclosed. In one embodiment, an apparatus includes a source of negative pressure, a coupling circuit, a driving circuit, and a controller. The driving circuit supplies a driving signal to the source of negative pressure via the coupling circuit to cause the source of negative pressure to provide negative pressure to a wound dressing. The coupling circuit includes an inductive reactance that limits a rate of change over time of the driving signal. The controller controls the driving signal supplied by the driving circuit.Type: ApplicationFiled: May 3, 2017Publication date: May 2, 2019Inventors: Ben Alan Askem, Victoria Beadle, John Philip Gowans, Mark Hesketh, Allan Kenneth Frazer Grugeon Hunt, William Kelbie, Damyn Musgrave, Joseph William Robinson
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Publication number: 20190125944Abstract: A self-contained ocular surgery instrument, including a power module having a body presenting a mating coupler and including a compressed gas supply; a fluid reservoir; an aspiration pump; an aspirated material reservoir and a control panel. The mating coupler is structured to receive and couple to at least one module that facilitates performance of an eye surgery task. The compressed gas supply is coupled to the aspiration pump and the aspirated material reservoir is in fluid communication with the aspiration pump to receive aspirated material from the mating coupler. The fluid reservoir is in fluid communication with the mating coupler such that fluid is supplied under pressure to the mating coupler and thus to the at least one module that facilitates performance of an eye surgery task. The control panel is in controlling communication with the compressed gas supply, the aspiration pump and the aspirated material reservoir.Type: ApplicationFiled: September 25, 2018Publication date: May 2, 2019Inventor: William F. Wiley
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Publication number: 20190125945Abstract: This disclosure includes wound dressings and systems for effluent management of topical wound therapy and related methods. Some devices, which are configured to dilute therapeutic gas effluent flowing from a dressing, comprise a therapeutic gas source configured to provide therapeutic gas to the dressing; a container comprising a sidewall that defines a chamber configured to receive therapeutic gas effluent from the dressing; a negative pressure source configured to be coupled to the container such that the negative pressure source can be activated to draw fluid from the dressing through the chamber of the container; and a diluent gas source configured to deliver a diluent gas to dilute therapeutic gas effluent before the therapeutic gas effluent enters the negative pressure source.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Inventors: Justin Alexander LONG, Christopher Brian LOCKE, Timothy Mark Robinson, Richard Coulthard
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Publication number: 20190125946Abstract: A highly portable advanced adult and pediatric compact ECLS system is based around an integrated pump-oxygenator. The system includes a central a blood inlet and flow path extending along a general longitudinal axis of the system; a pump housing defining a pump inlet in fluid communication with the central blood flow path; an impeller rotationally received within the area of the pump inlet, wherein the impeller is magnetically supported and magnetically driven; an array of hollow fiber membranes configured for gas transfer within the system for oxygenation of blood flowing across the hollow fiber membranes, wherein the membranes include a covalently-bonded heparin-based bioactive surface, and wherein the blood flow path extends from the impeller to a position to flow perpendicular over the array of hollow fiber membranes; and a blood outlet configured to receive blood flowing past the array of hollow fiber membranes.Type: ApplicationFiled: December 14, 2018Publication date: May 2, 2019Inventors: Mark Gartner, Minkyun Noh, David L. Trumper
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Publication number: 20190125947Abstract: A blood pump includes: a base body; a casing fitted thereon; a blood supply mechanism in a pump chamber surrounded by the base body and the casing; and a drive element. The base body has: a first contact surface to be in contact with the casing; and a first engaging portion including a first tapered portion inclined inward and downward. The casing has: a casing body having a second contact surface corresponding to the first contact surface; and a second engaging portion at an edge of the casing and including a second tapered portion inclined toward an r direction as the second tapered portion extends upward. The second engaging portion engages with the first engaging portion, and the second contact surface of the casing is pressed into contact with the first contact surface of the base body to prevent a gap between the first and second contact surfaces.Type: ApplicationFiled: April 20, 2016Publication date: May 2, 2019Inventor: Takayuki MIYAKOSHI
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Publication number: 20190125948Abstract: A heart assist device comprising a rotary pump housing having a cylindrical bore, a pumping chamber and a motor stator including an electrically conductive coil located within the housing and surrounding a portion of the cylindrical bore. A rotor has a cylindrical shaft with an impeller and one or of magnets located within the shaft that are responsive to the motor stator to drive actuation of the rotor. The housing bore is closely fitted to the outer surface of the shaft forming a hydrodynamic journal bearing with an annular clearance defining a leakage flow path. One or more of radial or axial thrust bearings may be provided to provide rotation stability to the rotor and flow within the leakage flow path. The relative orientation of positions of the inflow, outflow, and leakage flow paths may be varied within the pump, such as to accommodate different intended methods for implantation and/or use.Type: ApplicationFiled: October 30, 2018Publication date: May 2, 2019Inventors: J. Ryan Stanfield, Michael Vladovich
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Publication number: 20190125949Abstract: An implantable cardiovascular blood pump system is provided, suitable for use as a left ventricular assist device (LVAD) system, having an implantable cardiovascular pump, an extracorporeal battery and a controller coupled to the implantable pump, and a programmer selectively periodically coupled to the controller to configure and adjust operating parameters of the implantable cardiovascular pump. The implantable cardiovascular blood pump includes a coaxial inflow cannula and outflow cannula in fluid communication with one another and with a pumping mechanism. The pumping mechanism may be a vibrating membrane pump which may include a flexible membrane coupled to an electromagnetic actuator assembly that causes wavelike undulations to propagate along the flexible membrane to propel blood through the implantable cardiovascular pump.Type: ApplicationFiled: December 27, 2018Publication date: May 2, 2019Applicant: CorWave SAInventors: Carl N. BOTTERBUSCH, Silvere LUCQUIN, Jean-Baptiste DREVET, Adrien GUIGNABERT, Patrick MENEROUD
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Publication number: 20190125950Abstract: The invention relates to a medical treatment device comprising a fluid system, which has a monitoring apparatus 27 for monitoring the treatment device, wherein the monitoring apparatus 27 is configured such that monitoring is based on the evaluation of the pressure in the fluid system of the medical treatment device. The invention further relates to a method for monitoring a medical treatment device, in which monitoring is based on the evaluation of the pressure in the fluid system. The treatment device is characterised by a compliance-determining apparatus 28 for determining the compliance in the fluid system, part of the fluid system or parts of the fluid system, wherein the compliance-determining apparatus 28 cooperates with the monitoring apparatus 27 in such a manner that the pressure-based monitoring takes place depending on the compliance of the fluid system.Type: ApplicationFiled: April 11, 2017Publication date: May 2, 2019Inventor: Joachim Noack
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Publication number: 20190125951Abstract: A portable device for removal of metabolic waste from the blood of patient having kidney disease or in need of hemodialysis is provided. Methods of hemodialysis employing the portable device beneficially obtain a dialysate by electrokinetic means from excess fluid in the peripheral blood of the patient in need thereof. The methods employ a branched microfluidic channel for the use of ion concentration polarization to separate charged from neutral species in blood to obtain the dialysate for undergoing hemodialysis. Beneficially the methods and device are resistant to biofouling, remove the need for a dialysate and/or dialysate reservoir, and provide a disposable, wearable device.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Inventors: Robbyn K. Anand, Beatrise Berzina
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Publication number: 20190125952Abstract: A dialysis system includes: (i) a source of water made suitable for a dialysis treatment; (ii) at least one concentrate for mixing with the water from the source; (iii) a dialysis fluid pump; and (iv) a disposable set operable with the dialysis fluid pump and in fluid communication with the source of water and the at least one concentrate, the disposable set including a container having a first end and a second end, the container configured to allow the water and the at least one concentrate pumped by the dialysis fluid pump to enter at the second end and exit from the first end to mix for the dialysis treatment.Type: ApplicationFiled: October 30, 2018Publication date: May 2, 2019Inventors: Olof Jansson, Anders J. Wellings
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Publication number: 20190125953Abstract: The invention relates to a dialysis machine, in particular for hemodialysis and/or hemofiltration, having a dialyzate system and having a water inlet via which the dialyzate system can be connected to an external water supply, characterized in that a constant flow regulator is arranged between the water connection and the dialyzate system.Type: ApplicationFiled: June 2, 2017Publication date: May 2, 2019Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBHInventor: Christoph WIKTOR
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Publication number: 20190125954Abstract: A renal failure therapy system includes: (i) a dialysis fluid pumping unit including a dialysis fluid pump; (ii) a disposable set operable with the dialysis fluid pumping unit such that the dialysis fluid pump can pump dialysis fluid from the disposable set; (iii) a concentrate in fluid communication with the disposable set, wherein the concentrate is used to prepare the dialysis fluid; and (iv) a control unit operating the dialysis fluid pump, the control unit configured to cause a portion of the concentrate to fill at least a portion of the disposable set between treatments, the concentrate operating as a disinfectant allowing the disposable set to be used for multiple treatments with the same dialysis pumping unit.Type: ApplicationFiled: October 29, 2018Publication date: May 2, 2019Inventors: Sarah Lynn Mathiot, Anders J. Wellings, Jeffrey Cook, Edward Szpara, Anders Wieslander, Paul Straka
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Publication number: 20190125955Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.Type: ApplicationFiled: October 10, 2018Publication date: May 2, 2019Inventors: Yoram Vodovotz, Alexey Solovyev, David Okonkwo, Maxim Mikheev, Qi Mi, Jorg Gerlach, Gregory M. Constantine
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Publication number: 20190125956Abstract: A method is described to treat atherosclerosis by extracorporeally treating a patient's blood. A patient's blood is treated extracorporeally using a moiety that targets an antigen in the blood. The moiety facilitates removal of the blood antigen. The cleansed blood is then returned to the patient.Type: ApplicationFiled: November 20, 2017Publication date: May 2, 2019Inventor: Mitchell S. Felder
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Publication number: 20190125957Abstract: An attachable needle assembly (2) is disclosed for use on a medication delivery pen (4). The needle assembly (2) includes a housing (8) enclosing a hub (12) that is configured to engage the medication delivery pen (4), a plurality of needles (18) configured to pierce a reservoir septum (6) of the medication delivery pen (4), a selection ring insert (30) that rotates and identifies which needle (24) of the plurality of needles (18) is to be selected, and a selection ring (36) that applies a force to expose the selected needle (24). When the housing (8) is in a first position, the plurality of needles (18) is not exposed, and when the housing (8) is in a second position, one of the plurality of needles (24) is exposed for medicament delivery.Type: ApplicationFiled: March 31, 2017Publication date: May 2, 2019Applicant: Becton, Dickinson and CompanyInventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
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Publication number: 20190125958Abstract: An attachable needle assembly (102) for use on a medication delivery pen (104), the needle assembly (102) comprising a housing (1 10) enclosing a hub (106) having a communication needle (108) configured to engage the medication delivery pen (104) and pierce a reservoir septum of the medication delivery pen (104), a communication septum (172, 176) of the needle assembly (102) defining a septum chamber (180, 182) that is in fluid communication with the communication needle (108), a plurality of needles (118) disposed in the communication septum (172, 176), a follower ring (130) that determines which needle (124) of the plurality of needles (1 18) is to be selected, and a snap ring (136) that exposes the selected needle (124) and moves the selected needle (124) in fluid communication with the septum chamber (180, 182), wherein when the housing (110) is in a first position, the plurality of needles (118) is not exposed, and when the housing (110) is in a second position, the selected needle (124) is in fluid commType: ApplicationFiled: March 31, 2017Publication date: May 2, 2019Applicant: Becton, Dickinson and CompanyInventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
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Publication number: 20190125959Abstract: An attachable needle assembly (2) used on a medication delivery pen (4), the needle assembly (2) comprising a communication needle (10) configured to pierce a reservoir septum of the medication delivery pen (4), a spike housing (8) surrounding the communication needle (10) and configured to engage the medication delivery pen (4), a selector ring (16), including a selector opening (18), enclosing a septum (22, 30) of the needle assembly (2) defining a septum chamber (28, 29) that is in fluid communication with the communication needle (10), a plurality of needles (34) disposed in the septum (22, 30) of the needle assembly (2), and a peel tab (60) enclosing each of the plurality of needles (34), wherein the selector opening (18) is aligned with a selected peel tab (60) corresponding to a selected needle (40), the selected peel tab (60) is drawn out of the selector ring (16) and moves the selected needle (40) from a first position to a second position, and the selected needle (40) enters into fluid communicationType: ApplicationFiled: March 31, 2017Publication date: May 2, 2019Applicant: Becton, Dickinson and CompanyInventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
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Publication number: 20190125960Abstract: An automated insertion assembly includes a first dermal perforation assembly configured to releasably engage a first subdermal device. A first actuation assembly is configured to drive the first dermal perforation assembly into a user's skin to a first depth and drive the first subdermal device into the user's skin to a second depth. The second depth is greater than the first depth.Type: ApplicationFiled: November 21, 2018Publication date: May 2, 2019Inventor: Richard J. Lanigan
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Publication number: 20190125961Abstract: Removable tubing cartridges are described herein. A removable tubing cartridge includes an elongated cartridge body. The cartridge body further includes an upper lip disposed about the upper end of the cartridge body, wherein the upper lip extends axially away from the cartridge body. The cartridge can further include at least one lower fastener disposed about the lower end of the cartridge body, wherein the upper lip and the at least one lower fastener are configured to cooperatively align the cartridge body within the infusion pump. The cartridge can further include an upper tubing adapter cavity and a lower tubing adapter cavity that are configured to cooperatively align the pump segment tubing relative to the cartridge body.Type: ApplicationFiled: October 30, 2018Publication date: May 2, 2019Inventors: Brian William WARD, Lee William TRAVIS
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Publication number: 20190125962Abstract: A rotary pump for a fluid metering system is provided. The rotary pump reciprocates, and is reversed by a signal from a limit switch that is deflected by an actuator arm on a rotating sleeve of the pump system.Type: ApplicationFiled: July 31, 2018Publication date: May 2, 2019Applicant: Becton, Dickinson and CompanyInventors: Alessandro Pizzochero, Richard Gyory, Kenneth Focht, Justin Fisk, Joseph Gordon, Matthew Perry, Ajit D'Souza, Christopher Petroff
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Publication number: 20190125963Abstract: A wearable liquid supplying device for insulin injection is fixed on a user's body through a ring belt and includes a carrier body, a flow-guiding-and-actuating unit, a sensor, an air bag, a miniature air pump and a driving chip. The sensor measures sweat on human skin to detect a level of the blood glucose. The driving chip receives the glucose monitoring data and accordingly controls the actuation of the flow-guiding-and-actuating unit and the open/closed states of the switching valves. The miniature air pump is enabled to inhale gas into the air bag, so that the air bag is inflated and the ring belt contacts the human skin tightly. The flow-guiding-and-actuating unit is enabled to generate a pressure difference so that the insulin liquid is transported to a liquid guiding outlet through a liquid guiding channel and flows into the microneedle patch for being injected into the subcutaneous tissue.Type: ApplicationFiled: October 2, 2018Publication date: May 2, 2019Applicant: Microjet Technology Co., Ltd.Inventors: Hao-Jan Mou, Li-Pang Mo, Wei-Ming Lee, Chi-Feng Huang, Yung-Lung Han
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Publication number: 20190125964Abstract: A wearable liquid supplying device for human insulin injection is fixed on a body of human through a ring belt and includes a substrate, a flow-guiding-and-actuating unit, a sensor and a driving chip. The substrate has a liquid storage chamber. The flow-guiding-and-actuating unit has a liquid guiding channel in communication with a liquid storage outlet of the liquid storage chamber and a liquid guiding outlet. The sensor measures a blood glucose level and generates measured data correspondingly. The driving chip receives the measured data from the sensor and controls the actuation of the flow-guiding-and-actuating unit and the open/closed states of the switching valves. The flow-guiding-and-actuating unit is enabled to generate a pressure difference so that the insulin liquid is transported to the liquid guiding outlet through the liquid guiding channel and flows into the microneedle patch for allowing the microneedles to inject the insulin liquid into the subcutaneous tissue.Type: ApplicationFiled: October 2, 2018Publication date: May 2, 2019Applicant: Microjet Technology Co., Ltd.Inventors: Hao-Jan MOU, Li-Pang MO, Wei-Ming LEE, Chi-Feng HUANG, Yung-Lung HAN
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Publication number: 20190125965Abstract: A micro pump is applied to be implanted into human's blood vessels and includes a substrate, a flow-guiding-and-actuating unit, plural switching valves, a driving chip and a micro-mirror. The substrate has plural guiding channels including an inlet channel, an outlet channel and a branch channel. The flow-guiding-and-actuating unit covers a compressing chamber, and is enabled to change the volume of the compressing chamber so as to transport fluid. When a communication connector of the driving chip receives an external command, the driving chip enables the flow-guiding-and-actuating unit and the micro-mirror, and controls the open/closed states of the switching valves covering an outlet aperture and a storage outlet, thereby the flow-guiding-and-actuating unit drives the fluid medicine from a storage chamber to the outlet aperture, so as to deliver the fluid medicine to a target blood vessel.Type: ApplicationFiled: September 7, 2018Publication date: May 2, 2019Applicant: Microjet Technology Co., Ltd.Inventors: Hao-Jan Mou, Li-Pang Mo, Yung-Lung Han, Chi-Feng Huang, Chang-Yen Tsai
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Publication number: 20190125966Abstract: An implantable drug delivery device and method for delivering a drug to a living body. The device includes a housing having at least one opening, a reservoir within the housing adapted to contain a drug, a temporary seal closing the opening of the housing, and a heating element in thermal contact with the temporary seal. The heating element is adapted to generate heat in response to a magnetic field to melt the temporary seal and release a drug within the reservoir through the opening of the housing.Type: ApplicationFiled: October 4, 2018Publication date: May 2, 2019Inventors: Hyowon Lee, Bahar Dhowan
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Publication number: 20190125967Abstract: A liquid supplying device for a human insulin injection includes a substrate, a liquid storage chamber, a flow-guiding-and-actuating unit, a sensor and a driving chip. The flow-guiding-and-actuating unit includes a liquid guiding channel having a liquid guiding outlet in fluid communication with a liquid storage outlet of the liquid storage chamber. The sensor contacts with the human skin to measure a blood glucose level contained in sweat. The driving chip is configured to control the actuation of the flow-guiding-and-actuating unit, control open/closed states of the switching valves and receive the measured data from the sensor for determination. By driving the flow-guiding-and-actuating unit, a pressure gradient is generated, and an insulin liquid stored in the liquid storage chamber is transported to the liquid guiding outlet through the liquid guiding channel, flowing into a microneedle patch, and injected into a subcutaneous tissue through a plurality of hollow microneedles.Type: ApplicationFiled: October 2, 2018Publication date: May 2, 2019Applicant: Microjet Technology Co., Ltd.Inventors: Hao-Jan Mou, Li-Pang Mo, Hsuan-Kai Chen, Chi-Feng Huang, Yung-Lung Han