Patents Issued in May 7, 2019
  • Patent number: 10280101
    Abstract: The disclosed technology relates to water soluble, or partially water soluble, chain transfer agents for preparing water soluble polymers by Reversible Addition-Fragmentation Chain Transfer (“RAFT”) polymerization in an aqueous medium.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 7, 2019
    Assignee: The Lubrizol Corporation
    Inventors: Cory G. Miller, Hyungsoo Kim
  • Patent number: 10280102
    Abstract: A method of conditioning source water is comprised of: (a) acidifying source water by aluminum or iron chloride to prevent carboxylate from forming scale and emulsion and/or convert bicarbonate to carbon dioxide, and separating oil and/or carbon dioxide by hydrophobic membranes to produce a de-oiled and/or de-carbonated source water; (b) adding a hydrated lime or a hydrated lime with an amine solvent to separate magnesium hardness in the form of brucite and sulfate in the form calcium sulfoaluminate or calcium sulfoferrate to produce a de-brucited and de-sulfated source water; (c) if desired, reacting the excess amounts of the hydrated lime or the hydrated lime and amine solvent within the de-brucited and de-sulfated source water with carbon dioxide from step (a) to separate at least most of calcium hardness and produce a de-calcited source water; and (d) de-oxygenating the treated source water in step (b) or (c) by hydrophobic membranes.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: May 7, 2019
    Inventor: Mansour S. Bader
  • Patent number: 10280103
    Abstract: The invention presents innovative methods to de-scale sulfate-rich saline streams such as seawater and the like in conjunction with desalination processes. The effective de-scaling of such streams by the inventive methods: (1) enhances the performance, efficiency and cost effectiveness of desalination processes; and (2) allows the viable use of the de-scaled reject brine from desalination processes, for example, as a suitable saline water for oil-gas field's water injection operations to improve hydrocarbons recovery and/or as a feed stock for chlor-alkali industries.
    Type: Grant
    Filed: February 13, 2016
    Date of Patent: May 7, 2019
    Inventor: Mansour S. Bader
  • Patent number: 10280104
    Abstract: A method for removing mercury from flue gas in a flue gas desulfurization plant, in which the mercury concentration in the FGD gypsum is reduced without increasing the size of the waste water treatment plant, by increasing the volume-related mercury concentration in the wash wastewater and feeding this more concentrated flow of waste water to the waste water treatment plant.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: May 7, 2019
    Assignee: Andritz AG
    Inventors: Michael Kramer, Harald Reissner
  • Patent number: 10280105
    Abstract: A float glass chamber and related methods include a hot section having an atmosphere in at least the lower plenum with less than 3 percent hydrogen based on volume and a cold section having a different volume percent hydrogen.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: May 7, 2019
    Inventors: Charlene S. Smith, George A. Pecoraro
  • Patent number: 10280106
    Abstract: A bending mold capable of thermally bending an automotive windscreen comprises a fixed frame and two movable frames. A curvature adjusting apparatus is additionally provided corresponding to the bottom of each movable frame. Each curvature adjusting apparatus comprises two sidings, two hooks and an adjusting lever. The adjusting lever is in parallel to the connection line of two hinge connection points of the movable frame and the fixed frame on the same side, and the tops of the two hooks are respectively hanged on two corresponding sidings at adjustable positions. The process of thermally bending automotive glass can be accomplished with the bending mold, and does not require installing an anti-gravity mechanism. It has the advantages of simple mold structure design, less amount of materials and so on.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: May 7, 2019
    Assignee: Fuyao Glass Industry Group Co., Ltd.
    Inventors: Fai Tso, Kezhang Chi, Fu Liu, Jiangxing He, Guohai Zeng, Guoqiang Guan
  • Patent number: 10280107
    Abstract: The present invention relates to a method for separating solid-body slices (1) from a donor substrate (2). The method comprises the steps of: producing modifications (10) within the donor substrate (2) by means of laser beams (12), wherein a detachment region is predefined by the modifications (10), along which detachment region the solid-body layer (1) is separated from the donor substrate (2), and removing material from the donor substrate (2), starting from a surface (4) extending in the peripheral direction of the donor substrate (2), in the direction of the center (Z) of the donor substrate (2), in particular in order to produce a peripheral indentation (6).
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: May 7, 2019
    Assignee: Siltectra, Gmbh
    Inventors: Marko Swoboda, Christian Beyer, Franz Schilling, Jan Richter
  • Patent number: 10280108
    Abstract: The present invention relates to a method for producing a contour in a planar substrate and for separating the contour from the substrate, in particular for producing an internal contour in a planar substrate and for removing the internal contour from the substrate, wherein, in a contour definition step by means of a laser beam guided over the substrate along a contour line characterizing the contour to be produced, a large number of individual zones of internal damage is produced in the substrate material, in a crack definition step by means of a laser beam guided over the substrate along a plurality of crack line portions, which, viewed from the contour line, leads away at an angle a>0°, and into the contour to be separated, respectively a large number of individual zones of internal damage is produced in the substrate material and, in a material removal step implemented after the contour definition step and after the crack definition step by means of a material-removing laser beam guided over the substr
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: May 7, 2019
    Assignee: CORNING LASER TECHNOLOGIES GMBH
    Inventor: Rico Bohme
  • Patent number: 10280109
    Abstract: A method for producing sulfide glass wherein phosphorus sulfide satisfying the following formula (1) is used as a raw material: 100×A/B?37??(1) wherein in the formula, A is peak areas of peaks that appear at peak positions in a range of 57.2 ppm or more and 58.3 ppm or less, and 63.0 ppm or more and 64.5 ppm or less in 31PNMR spectroscopy, and B is the total of peak areas of all peaks measured in 31PNMR spectroscopy.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: May 7, 2019
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventors: Akiko Nakata, Junpei Maruyama
  • Patent number: 10280110
    Abstract: This disclosure relates to a method for strengthening an edge of a glass plate, a glass, and a display apparatus, wherein the article comprises a side surface located at the edge, and the method for strengthening an edge of an article comprises the steps of: applying an etching paste at least to the side surface of the article to perform etching so as to strengthen the edge of the article; and removing the etching paste.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: May 7, 2019
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., HEFEI XINSHENG OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventors: Lei Zhang, Taofeng Xie, Lingyan Wu, Yang Liu
  • Patent number: 10280111
    Abstract: An energy-saving glass includes a glass substrate, and a periodic metal layer deposited on the glass substrate and having a honeycomb array of round holes. A method of manufacturing the energy-saving glass includes: providing a template having multiple template spots arranged in a honeycomb array; forming on the template a transfer metal layer having multiple metal spots disposed respectively on the template spots; transferring the metal spots onto a photoresist layer on a glass substrate; etching the photoresist layer exposed from the metal spots to leave photoresist spots underlying the metal spots on the glass substrate; forming a periodic metal layer around the photoresist spots; and removing the photoresist spots.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: May 7, 2019
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Yu-Bin Chen, Fu-Yuan Shih, Yung-Chun Lee, Wei-Xiang Su
  • Patent number: 10280112
    Abstract: An article comprising an ion-exchanged glass material that prevents sharp contact flaws from entering a central region of the material that is under central tension and thus causing failure of the material. The glass material may be a glass or glass ceramic having a surface layer under compression. In some embodiments, the depth of the compressive layer is greater than about 75 ?m. The greater depth of layer prevents flaws from penetrating the compressive layer to the region under tension.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: May 7, 2019
    Assignee: CORNING INCORPORATED
    Inventor: Timothy Michael Gross
  • Patent number: 10280113
    Abstract: There are provided a manufacturing method of a glass member capable of being cut well without causing a decrease in strength even by using laser light to form a reformed region inside a glass and cutting the glass along the reformed region, and a glass member obtained by the manufacturing method. A glass member 100 having, as a main body thereof, a glass substrate 110 including: strengthened principal surfaces 110a and an end surface; a reformed region R formed on the end surface made by light radiated to be focused thereto, in which a tension stress (CT) of a center portion in a tension stress region, a fracture toughness (K1c) of the glass substrate, and a crack initiation load (CIL) of the glass substrate satisfy a predetermined expression.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: May 7, 2019
    Assignee: AGC Inc.
    Inventor: Hidetaka Masuda
  • Patent number: 10280114
    Abstract: Method of operating a long direct-fired inclined counterflow rotary kiln for the thermal treatment of material and counterflow rotary kiln adapted for same, whereby material to be treated is introduced into the kiln at the inlet end and treated material is evacuated from the kiln at the outlet end, whereby a main combustion zone extends inside the kiln over a distance of ¼ to ? of the internal length Lint of the kiln, whereby a supplementary combustion zone in which supplementary combustion takes place with an oxygen-rich oxidant extends inside the kiln over a distance from the inlet end of at most ¼ of the internal length Lint, and whereby no combustion takes place in a heat exchange zone located between the main combustion zone and the supplementary combustion zone.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: May 7, 2019
    Assignee: L'Air Liquide Societe Anonyme Pour L'Etude Et L'Exploitation Des Procedes Georges Claude
    Inventors: Bernard Labegorre, Carlo Renna, Remi Tsiava, Sergio Fernandes
  • Patent number: 10280115
    Abstract: A fluidized calciner is provided which allows a reduction in the rate of unburned fuel at an outlet of a fluidized calciner to enable sufficient calcination while preventing possible occlusion in a preheater, even when pulverized coal of coal or coke, which has low combustion quality, is used as fuel, based on calculations in accordance with computational fluid dynamics based on the shape of an actual furnace and operational conditions.
    Type: Grant
    Filed: December 25, 2013
    Date of Patent: May 7, 2019
    Assignee: MITSUBISHI MATERIALS CORPORATION
    Inventors: Yoshinori Takayama, Junzhu Wang
  • Patent number: 10280116
    Abstract: The invention relates to an additive mixture for addition to a building material covering mixture for forming a composite covering system for the floor, wall, or facade area, which additive mixture reduces the thermal conductivity or thermal dissipation of covering systems, in particular the thermal dissipation through objects and sub-bases coated with the covering system, in such a way that walking on the sub-base provided with the covering system is no longer associated with a sensation of cold feet. This is achieved in that the additive mixture has a proportion of between 50% wt and 95% wt of Muscovite mica.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: May 7, 2019
    Assignee: Synfola GmbH
    Inventor: Kaspar Hauser
  • Patent number: 10280117
    Abstract: An admixture includes a cementitious component, an unprocessed biomass component, calcium chloride, calcium carbonate, and an adhesive element. The admixture is suitable for mixing with water to form a flowable material that cures to produce a hardened material. A flowable material includes the admixture and water. A method of producing a flowable material includes turning on a mixer and adding an unprocessed biomass component to a drum of the mixer. The unprocessed biomass component is sprayed with an adhesive element to form a first composition. Calcium carbonate is added to the first composition in the mixing chamber, to form a second composition. The second composition is mixed. A cementitious component is added to the mixed second composition in the mixing chamber, to form a third composition, which is mixed with water and calcium chloride to produce the flowable material. The flowable material cures to form the hardened material.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: May 7, 2019
    Assignee: SBC Group LLC
    Inventors: Robert Douglas Morris, James Paul Johnson, Raymond W. Eley, Jr., Christopher Klee Baird Morris
  • Patent number: 10280118
    Abstract: A composition of matter as well as a protective coating or article manufactured from the composition produced by preparing a non-flammable mixture by mixing (I) at least one water-soluble alkali metal silicate selected from the group consisting of sodium silicate, potassium silicate, and combinations thereof; (II) sodium aluminosilicate, which, in the process of interacting with a soluble alkali metal silicate under heat and/or fire, substantially expands and produces foam, which provides heat/fire protection for surfaces, (III) at least one chemical selected from the group consisting of silica, mica, talc, microspheres, glass, ceramic, chopped fibers, plaster of Paris, sodium bicarbonate, cement, perlite, zinc oxide, zeolite, wollastonite, vermiculate, clay, borax and alumina, which, in the process of interacting with a soluble alkali metal silicate and sodium aluminosilicate, accelerates the processes of interaction and improves the mechanical, physical and thermal properties including providing stability o
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: May 7, 2019
    Inventors: Felix A Dimanshteyn, Adam Dimanshteyn
  • Patent number: 10280119
    Abstract: A barium titanate piezoelectric ceramic having good piezoelectric properties and mechanical strength and a piezoelectric element that includes the ceramic are provided. A method for making a piezoelectric ceramic includes forming a compact composed of an oxide powder containing barium titanate particles, sintering the compact, and decreasing the temperature of the compact after the sintering. The sintering includes (A) increasing the temperature of the compact to a first temperature within a temperature range of a shrinking process of the compact; (B) increasing the temperature of the compact to a second temperature within a temperature range of a liquid phase sintering process of the compact after (A); (C) decreasing the temperature of the compact to a third temperature within the temperature range of the shrinking process of the compact after (B); and (D) retaining the third temperature after (C).
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: May 7, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventors: Takanori Matsuda, Hiroshi Saito, Tatsuo Furuta, Jumpei Hayashi, Takayuki Watanabe, Toshihiro Ifuku
  • Patent number: 10280120
    Abstract: Provided is a zirconia sintered body that suppresses discoloration due to porcelain. The zirconia sintered body comprises at least one of a coloring agent A: erbium oxide and a coloring agent B: nickel oxide, and a composite oxide of zirconium and vanadium.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: May 7, 2019
    Assignee: KURARAY NORITAKE DENTAL INC.
    Inventors: Yoshihisa Ito, Atsushi Matsumoto, Tomohiro Emoto
  • Patent number: 10280121
    Abstract: A silicon carbide member for a plasma processing apparatus is obtained by mixing an ?-silicon carbide powder having an average particle size of 0.3 to 3 ?m, with an amount of metal impurities in the ?-silicon carbide powder reduced to 20 ppm or less, and a sintering aid comprising B4C in amount of 0.5 to 5 weight parts or Al2O3 and Y2O3 in total amount of 3 to 15 weight parts; sintering a mixture of the ?-silicon carbide powder and the sintering aid in an argon atmosphere furnace or a high-frequency dielectric heating furnace; and then processing the resulting sintered body. The resulting silicon carbide member for a plasma processing apparatus is low cost and durable.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 7, 2019
    Assignee: HOKURIKU SEIKEI INDUSTRIAL CO., LTD.
    Inventors: Masahiro Okesaku, Michito Miyahara, Hideo Eto, Yukio Okudo, Makoto Saito, Hiroshi Sanda
  • Patent number: 10280122
    Abstract: Various embodiments disclosed relate to compositions including a plurality of capsules each independently comprising an outer wall and an inner compartment, the inner compartment independently comprising at least one of a first hardenable resin, a first hardener or activator, and a solvent, self-healing hardened resins formed from the same, and methods of using the same. In various embodiments, the present invention provides a method of treating a subterranean formation including placing the composition in a subterranean formation, and forming a selfhealing hardened resin in the subterranean formation from the composition.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 7, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Rajender Salla, Mallikarjuna Shroff Rama, Jag Pravesh
  • Patent number: 10280123
    Abstract: A fertilizer that may be comprised of water soluble soy protein and one or more species of beneficial microbes that aid in plant nourishment and soil enhancement, where the beneficial microbes may be Bacteria or Archae microbes.
    Type: Grant
    Filed: April 1, 2017
    Date of Patent: May 7, 2019
    Assignee: Easy Gardener Products, Inc.
    Inventor: Martin Rainey
  • Patent number: 10280124
    Abstract: The present invention relates to an active crystalline material, especially an active multicomponent crystalline material such as a salt or a cocrystal, which may be made by dispersing precursor components of the active crystalline material in a liquid medium which comprises an anti-solvent, maintaining the dispersion for a period during which the active crystalline material is formed, and, during said period, exposing the dispersion to a solvent, which solvent being present in the liquid medium in a minor proportion by weight thereof.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: May 7, 2019
    Assignee: CPI Innovation Services Limited
    Inventors: Ruksanna Ahmad, Jeremy Cooper, Isaac Odiase
  • Patent number: 10280125
    Abstract: A process for selectively producing 1-butene comprises contacting at least one antifouling agent with at least one aluminum alkyl compound to form at least one antifouling compound in a first step. The antifouling compound may comprise a structure comprising a central aluminum molecule bound to an R1 group, bound to an R2 group, and bound to an R3 group. The process further comprises feeding the antifouling compound, an additional amount of the aluminum alkyl compound, at least one titanate compound, and ethylene into a reactor to dimerize ethylene in a second step. The titanate compound is fed as a stream separated from the streams of the antifouling compound and the additional amount of the aluminum alkyl compound. The molar ratio of the sum of the aluminum alkyl compound to the titanate compound is equal to or higher than 1.5 and equal to or lower than 3.0.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: May 7, 2019
    Assignees: Sumitomo Chemical Company, Limited, Saudi Arabian Oil Company
    Inventors: Kenji Sogo, Sohel K. Shaikh, Zhonglin Zhang, Wei Xu, Yohei Kashiwame
  • Patent number: 10280126
    Abstract: A method for producing a conjugated diene according to one aspect of the present invention comprises a step of contacting a raw material gas containing an olefin with a dehydrogenation catalyst to obtain a product gas containing a conjugated diene. In the production method, the dehydrogenation catalyst contains Al, a group 14 metal element, and Pt, and a content of the group 14 metal element in terms of oxide in the dehydrogenation catalyst is 9% by mass or more and 50% by mass or less based on the total mass of the dehydrogenation catalyst.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: May 7, 2019
    Assignees: JXTG NIPPON OIL & ENERGY CORPORATION, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY
    Inventors: Hideki Kurokawa, Tatsuya Ichijo, Nobuhiro Kimura
  • Patent number: 10280127
    Abstract: An integrated process and system to generate power and convert acyclic C5 feedstock to non-aromatic, cyclic C5 hydrocarbon. A combustion device, such as a turbine, and reactor tubes containing catalyst compound are disclosed. A process involving contacting acyclic C5 feedstock with catalyst composition and obtaining cyclic C5 hydrocarbon is also disclosed.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: May 7, 2019
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Larry L. Iaccino, Romain O. V. Lemoine
  • Patent number: 10280128
    Abstract: In a process for alkylating an aromatic hydrocarbon feedstock with an olefin feedstock, at least one of the aromatic hydrocarbon and olefin feedstocks is passed through a pretreatment unit containing an adsorbent such that the adsorbent removes impurities contained by the feedstock. Passage of the at least one feedstock through the pretreatment unit is then terminated and a heated inert gas is passed through the pretreatment unit such that the inert gas desorbs impurities from the adsorbent to produce an inert gas effluent stream containing the desorbed impurities. A condensable fluid is added to at least part of the inert gas effluent stream such that at least a portion of the impurities contained therein condense with said fluid to leave a purified inert gas stream, which is recycled to the pretreatment unit.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: May 7, 2019
    Assignee: BADGER LICENSING LLC
    Inventors: Brian Maerz, Douglas Hubbell, Maruti Bhandarkar, Vijay Nanda
  • Patent number: 10280129
    Abstract: To provide a method for stably storing tetrafluoropropene filled in a container for e.g. storage or transportation, without occurrence of reaction such as polymerization. A method for storing tetrafluoropropene in a gaseous-liquid state composed of a gas phase and a liquid phase in a closed container, wherein the oxygen concentration (content) in the above gas phase is adjusted to at least 3 vol ppm and less than 3,000 vol ppm at a temperature of 25° C.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: May 7, 2019
    Assignee: AGC Inc.
    Inventors: Masato Fukushima, Masaaki Tsuzaki, Maki Shigematsu
  • Patent number: 10280130
    Abstract: The present invention is directed to a new class of thermoplastic elastomers (TPEs) and processes for making them. In some embodiments of the present invention, the end groups of the multi-arm PIB copolymer is a conjugated diene, whereas the other component is a multi-functional dienophile. The components of the TPE of the present invention are chemically connected via the well-known Diels-Alder reaction which is thermally reversible (by the retro-Diels-Alder reaction) at moderately elevated temperatures. The reversibility of the Diels-Alder retro-Diels-Alder reactions allows the recovery of the original components of the TPE and thus its recyclability and also gives the TPE the ability to be reshaped or reformed.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: May 7, 2019
    Assignee: THE UNIVERSITY OF AKRON
    Inventors: Joseph P. Kennedy, Turgut Nugay, Nihan Nugay
  • Patent number: 10280131
    Abstract: The invention relates to terpene-derived acids and esters thereof as well as to processes for synthesizing them.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: May 7, 2019
    Assignee: P2 SCIENCE, INC.
    Inventors: Patrick Foley, Yonghua Yang, Robert Bedoukian, Thomas Killinger
  • Patent number: 10280132
    Abstract: A carboxylic acid is transvinylated with vinyl ester to give a vinyl ester product and the corresponding acid of the vinyl ester in the presence of a catalyst, at a temperature of 100° C. to 170° C. and a pressure of 2 bar abs. to 15 bar abs., wherein the vinyl ester, the carboxylic acid and the catalyst are supplied to a reactor, the transvinylation reaction is conducted, and, on the completion of the transvinylation, the vinyl ester product is separated from the reaction mixture by distillation, characterized in that the reaction mixture is decompressed in a decompression vessel, the gaseous phase obtained is condensed and recycled into the reactor without further purification, and the liquid phase obtained is freed of vinyl ester and corresponding acid with a first distillation, and the vinyl ester product is separated from the reaction mixture in a further distillation step.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: May 7, 2019
    Assignee: WACKER CHEMIE AG
    Inventors: Peter Schultheiss, Volker Hoellein, Brigitte Patsch
  • Patent number: 10280133
    Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: May 7, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Weitong Dong, Christian Wolfgang Hemp, Xiangle Jin, Jun Lu, Ulrich Scholz, Shengmin Su, Wei Xu, Jinsong Yang
  • Patent number: 10280134
    Abstract: The invention is directed to 2-aryl hydrazonopropanals that exert anti-tumor activity and methods for using them to prevent, inhibit and treat cancer. It also involves anti-tumor compositions containing these 2-aryl hydrazonopropanals, and methods of treatment using these compositions.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 7, 2019
    Assignee: King Abdulaziz University
    Inventors: Khadijah M. Al-Zaydi, Tamer S. Saleh, Taibi Ben Hadda
  • Patent number: 10280135
    Abstract: The invention relates to a continuously operated method for producing isocyanates by reacting the corresponding amines with phosgene. When changing the target production capacity starting from a starting state with a specified production capacity and ending with an end state with a different production capacity, the current excess phosgene at the time of the transition period between the starting state and the end state, the change of the amine mass flow beginning during said time, is at least equal to and preferably greater than the excess phosgene during the production period when the production capacity is in the starting state prior to the beginning of the transition period; and the average excess phosgene during the transition period is greater than the excess phosgene during the production period when the production capacity is in the starting state prior to the beginning of the transition period.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: May 7, 2019
    Assignee: Covestro Deutschland AG
    Inventors: Thomas Knauf, Dirk Manzel, Peter Plathen, Stefan Wershofen
  • Patent number: 10280136
    Abstract: A continuous flow process for the preparation of one or more esters of lactic acid and 2-hydroxy-3-butenoic acid or ?-hydroxy methionine analogs from a sugar in the presence of a solid Lewis acid catalyst and a solvent comprising an organic solvent and water. The invention provides a stabilized Lewis acid catalyst for use in a continuous reaction process, where the water is present in an amount of up to or equal to 10 vol. % of the organic solvent.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: May 7, 2019
    Assignee: Haldor Topsoe A/S
    Inventors: Irantzu Sadaba Zubiri, Esben Taarning
  • Patent number: 10280138
    Abstract: The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: May 7, 2019
    Assignee: NICOX S.A.
    Inventors: Nicoletta Almirante, Laura Storoni, Elena Bastia, Stefania Brambilla, Francesco Impagnatiello
  • Patent number: 10280139
    Abstract: Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: May 7, 2019
    Assignee: Novartis AG
    Inventors: Bernhard Hubert Geierstanger, Jan Grunewald, Weijia Ou, Shifeng Pan, Tetsuo Uno, Yongqin Wan, Xing Wang
  • Patent number: 10280140
    Abstract: The present invention relates to a method for the production of a pyrrolidine derivative.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: May 7, 2019
    Assignee: Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet
    Inventors: Bernhard Hirt, Claus Zeyher
  • Patent number: 10280141
    Abstract: The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same and methods of making and using the same.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 7, 2019
    Assignee: OTSUKA AMERICA PHARMACEUTICAL, INC.
    Inventors: Anthony Alexander McKinney, Franklin Bymaster, Walter Piskorski, Fred J. Fleitz, Yonglai Yang, David A. Engers, Valeriya Smolenskaya, Venkat Kusukuntla
  • Patent number: 10280142
    Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 7, 2019
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Yoichiro Kuninobu, Motomu Kanai, Haruka Ida, Mitsumi Nishi
  • Patent number: 10280143
    Abstract: There is provided a process for preparing a compound represented by the following general formula (1) or a salt thereof, which comprises exchanging one or more of an amino proton in a compound represented by the following general formula (2) or a salt thereof to deuterium, and after the exchanging, converting a deuterium-exchanged compound of the compound represented by the general formula (2) or a salt thereof into the compound represented by the general formula (1) or a salt thereof: wherein, in the general formula (1), one, or two or more of hydrogen atom may be substituted with their isotope; and in the general formula (2), each of R1 is independently hydrogen atom, tert-butyloxycarbonyl group or benzyloxycarbonyl group, and R2 is independently tert-butyl group, benzyl group, methyl group or ethyl group.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: May 7, 2019
    Assignee: SOPHIA SCHOOL CORPORATION
    Inventor: Toyonobu Usuki
  • Patent number: 10280144
    Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: May 7, 2019
    Assignee: Genentech, Inc.
    Inventors: Benjamin Fauber, James J. Crawford, Sarah M. Bronner, Monique Bodil van Niel, Andrew Cridland, Emanuela Gancia, Christopher Hurley, Jonathan Killen, Stuart Ward
  • Patent number: 10280145
    Abstract: A compound has inhibitory activity on Discoidin Domain Receptor 1. A urea derivative is represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein, R1 is trifluoromethyl, trifluoromethoxy, or pentafluorosulfanyl; each R2 is independently a hydrogen atom or methyl which is optionally substituted by one hydroxyl or one saturated heterocyclyl having four to six ring-forming atoms; R3 is a hydrogen atom, halogen atom, C1-C3 alkyl, saturated heterocyclyl having four to six ring-forming atoms and optionally having an oxo group, or R5O—; and R4 is phenyl, pyridyl, pyridazinyl, or pyrimidinyl, which phenyl, pyridyl, pyridazinyl, or pyrimidinyl is optionally substituted by one R6.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 7, 2019
    Assignee: Toray Industries, Inc.
    Inventors: Yukihiro Nishio, Yuko Kubota, Masashi Yamamoto, Yutaka Nishimura, Tomohide Masuda, Hideyuki Tsutsui, Keiichi Okimura, Syuji Udagawa, Mie Kaino, Hiroyuki Meguro, Yumiko Sekiya
  • Patent number: 10280146
    Abstract: The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 7, 2019
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Jianhua Shen, Yiping Wang, Xinde Chen, Wenwei Xu, Kai Wang
  • Patent number: 10280147
    Abstract: A solid-supported catalyst ligand which chelates palladium (II) species to form a complex that functions as a heterogeneous catalyst that is stable and can be recycled without significantly losing any catalytic activity in a variety of chemical transformations, a method for producing the solid-supported catalyst ligand and a method for catalyzing a palladium cross-coupling reaction, such as the Suzuki-Miyaura, Mizoroki-Heck, and Sonagashira reactions.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: May 7, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Bassam El Ali, Rami Khalid Suleiman, Mansur Bala Ibrahim
  • Patent number: 10280148
    Abstract: Provided is an electroconductive member for electrophotography in which movement of a quaternary ammonium salt toward the surface of a binder resin is suppressed and which exhibits a less reduction in electroconductivity through electrification. The electroconductive member for electrophotography comprises an electroconductive shaft core and a resin layer, and the resin layer comprises a binder resin and at least one selected from quaternary ammonium salts having structures represented by the formulae (1) to (8).
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: May 7, 2019
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Satoru Nishioka, Satoru Yamada, Kazuhiro Yamauchi, Yuichi Kikuchi
  • Patent number: 10280149
    Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 7, 2019
    Assignees: GENENTECH, INC., CONSTELLATION PHARMACEUTICALS, INC.
    Inventors: Brian K. Albrecht, Alexandre Cote, Victor Gehling, Vickie Hsiao-Wei Tsui, James Richard Jr. Kiefer, Jun Liang, Steven Magnuson, Christopher G. Nasveschuk, Richard Pastor, F. Anthony Romero, Alexander M. Taylor, Birong Zhang
  • Patent number: 10280150
    Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: May 7, 2019
    Assignee: FORMA TM2, INC.
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, Jr., Justin Andrew Caravella, Wei Lu
  • Patent number: 10280152
    Abstract: Provided herein are radiolabelled compounds useful for imaging GSK-3 kinase. An exemplary radiolabelled compound provided herein is useful as a radiotracer for imaging GSK-3 kinase using PET imaging. Methods for preparing the radiolabelled compounds and diagnostic methods using the radiolabelled compounds are also provided.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: May 7, 2019
    Assignee: The General Hospital Corporation
    Inventors: Neil Vasdev, Huan Steven Liang