Abstract: A bridge assembly is described for use with a patient positioning system including a patient support panel. The panel includes a pair of side rails extending along a central longitudinal axis of the panel. The bridge assembly is configured to be releasably secured via respective clamps at any position along the side rails and includes a pair of side sections and a central section connected between the side sections. The length of each side sections can be adjusted independently to enable the distance of the central section at each of the side sections from the patient support panel to be individually established. The central section can also be adjusted laterally with respect to the central longitudinal axis of the patient support panel.

Abstract: A compliant bimanual rehabilitation system. The device allows for the user or operator's hands to be coupled with a variety of coupling stiffnesses and in a variety of symmetry modes, leading to enhanced rehabilitation of the impaired arm. Structurally, the device includes a carrier assembly slidably coupled to a base along a y-axis, an upper assembly rotatably coupled to the carrier assembly along a z-axis, handle slides slidably coupled to the upper assembly along an x-axis, compliant handle assemblies coupled to the handle slides, and handles coupled to the compliant handle assemblies. Encoders and load cells can also be positioned accordingly to monitor the position of the components and force applied to the device. Spring stacks can be coupled to the compliant handle assemblies to adjust coupling stiffnesses. The handles are indirectly linked to each other to facilitate rehabilitation of the paretic arm using the sound arm.

Abstract: A wearable thorax percussion device for dislodging mucous buildup in the airways of a human patient, the device comprising frame elements and electromechanical actuators retained by the frame elements to intermittently percuss the thorax, and an electronic controller and power source for generating and modulating an electrical signal to energize the actuator. The frame elements may be interconnected by a garment, or fasteners and elastic or adjustable strapping.

Abstract: A robotic walker and associated method are provided. The robotic walker includes a housing containing a control unit operatively connected to a drive unit. The drive unit is operatively connected to a pair of motorized drive wheels. The robotic walker includes first and second winches, each winch having a strap that can be retracted by its respective winch, each winch is operatively connected to the drive unit, each strap having an end adapted to be removably connected to a pair of leg braces worn by a user. The first and second winches may retract a portion of each respective strap to move the legs of the user forward. A first control button is operatively connected to the control unit. The control unit is configured to operate the robotic walker in at least one control mode and the first control button being operable to start the at least one control mode.

Abstract: A pneumatic lower extremity gait rehabilitation training system includes a support device for reducing the burden of supporting a user's body weight by lower extremity in a walking therapy, an exoskeleton rehabilitation device for adjusting the user's walking coordination at a treadmill, a center-of-gravity adjusting device for adjusting a change of upper and lower centers of gravity, and a remote monitoring device for receiving and capturing a signal of an angle displacement of a joint mechanism in a walking cycle. The user may support her/his body weight by the support device and the center-of-gravity adjusting device to reduce the gravity exerted onto the user's legs. The exoskeleton rehabilitation device improves the flexibility, safety and lightweight of walking and requires fewer driving elements. The remote monitoring device sends analyzed signals to the treadmill to adjust the user's walking speed, so as to improve the rehabilitation effect.

Abstract: A wrap around walking aid is configured to assist a human user in walking. The wrap around walking aid includes a first rear lower frame and a first front lower frame mechanically coupled to a first upper frame. A back rest is connected to the first rear lower frame. A second rear lower frame and a second front lower frame are mechanically coupled to a second upper frame. The second rear lower frame is further mechanically coupled to the back rest. At least one first fixed front wheel is mechanically coupled to both front lower frames. At least one first castor rear wheel is mechanically coupled to both rear lower frames. The wheels enable a turn radius while the human user is walking forward.

Abstract: A compression therapy device may include a compression therapy appliance comprising a number of independently inflatable cells and a controller to control a flow of a pressurizing fluid into and out of each cell via a number of valves. The controller may direct the valves to inflate or deflate each cell in a sequence according to one or more compression therapy protocols. The compression therapy appliance may be placed on a portion of a patient's body to provide compression therapy according to one or more of the compression therapy protocols. The portion of the patient's body in contact with the compression therapy appliance may include a proximal end and a distal end. A compression therapy protocol may include alternating inflation and deflation steps of one or more cells placed in contact with the proximal end of the patient's body, thereby improving fluid flow into the proximal end of the patient.

Abstract: A heel protector (100) includes a leg engaging section (101) and a foot engaging section (102) intersecting at a heel receiver (103). The leg engaging section (101) and the foot engaging section (102) define a leg insertion aperture (104). The leg engaging section (101) defines at least one aperture (203) disposed in an ankle region (205) to permit a connection tube (1002) extending from an inflatable bladder (901) of a compression device (800) to pass therethrough. The heel protector (100) and compression device (800) work together as a rehabilitation system (1300).

Abstract: The present invention is a physiological measurement and stimulation device that can autonomously adapt its actuation output behavior based on acquired data in the form of biofeedback sensory measurements. When operating the invention, the user can place the device on the body at the intended area of operation, at which time the physiological measurements sensors can initiate data collection. Either prior to or following this time, the actuator can be activated and controlled manually and/or autonomously per a command signal generated by the control system. The operation of the present invention can be continued until the invention detects that a predetermined threshold has been reached. When the invention is used as a sexual stimulation device, the predetermined threshold can be physiological data corresponding to various stages of arousal or orgasm.

Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.

Abstract: A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.

Abstract: A CPR machine (100) is configured to perform compressions on a patient's (182) chest that alternate with releases. The CPR machine includes a compression mechanism (148), and a driver system (141) configured to drive the compression mechanism. A compression force may be sensed, and the driving is adjusted accordingly if there is a surprise. For instance, driving may have been automatic according to a motion-time profile, which is adjusted if the compression force is not as expected (850). An optional chest-lifting device (152) may lift the chest between the compressions, to assist actively the decompression of the chest. A lifting force may be sensed, and the motion-time profile can be adjusted if the compression force or the lifting force is not as expected. An advantage is that a changing condition in the patient or in the retention of the patient within the CPR machine may be detected and responded to.

Abstract: An embodiment of the support structure includes a back plate, a central part adapted to recite an automatic compression/decompression unit, and a front includes two legs coupled between the central part and the back plate. The support structure is arranged to automatically compress or decompress a patient's chest when the front part is attached to the back plate and when the compression/decompression unit is received in the central part.

Abstract: The present invention relates generally to a support structure for fixating a patient to a treatment unit, and especially to a support structure for fixating the patient to a cardiopulmonary resuscitation unit. An embodiment of the support structure includes a back plate for positioning behind said patient's back posterior to said patient's heart and a front part for positioning around said patient's chest anterior to said patient's heart. Further, the front part can include two legs, each leg having a first end pivotably connected to at least one hinge and a second end removably attachable to said back plate. Said front part can further be devised for including a compression/decompression unit arranged to automatically compress or decompress said patient's chest when said front part is attached to said back plate.

Abstract: Systems, apparatus and methods for providing air and water to hot tub jets. The present teachings include jet assemblies, manifold assemblies, and related components, as well as methods of assembling hot tubs involving these components. In some cases, the present teachings describe the use of dual extrusion tubing to route air and water through adjacent, connected fluid conduits. In some cases, the present teachings describe a “press-and-click” method of connecting various components.

Abstract: The present invention relates to a device for treating obesity using cooling, the device comprising: a controller body for setting a cooling temperature and operating time, supplying cooling water for cooling a thermoelectric element, and providing suction force through a vacuum pump; a handpiece body for displaying operating conditions and providing suction force through a suction hole; a cable for connecting the controller body and the handpiece body; a suction cup mounted on the handpiece body to form a suction space; and cooling devices positioned on opposite sides of the suction cup to cool a part to be treated, which has been sucked into the suction space. Further, metallic cooling plates in-molded in a suction cup made of silicone make contact with the part to be treated via a thin silicone layer such that fat can be destroyed efficiently using a small amount of anti-freezing agent while protecting the skin.

Abstract: A vial adaptor can include a connector interface and/or a piercing member. The vial adaptor can include a regulator assembly. The regulator assembly can include a regulator base, a regulator nest coupled with the regulator base, and/or a storage chamber formed at least partially by one or both of the regulator base and regulator nest. The regulator assembly can include a cover connected to one or both of the regulator base and regulator nest and fitted around a radially outward portion of one or both of the regulator base and regulator nest. In some cases, the regular assembly includes a flexible enclosure connected to the regulator nest and configured to transition between a contracted configuration and an expanded configuration. In some cases, the flexible enclosure is inhibited from transitioning to the expanded configuration prior to removal or modification of the cover from the regulator assembly.

Abstract: The present invention relates to an intelligent medication dispensing device that gives a patient access to his/her right daily doses of oral solid medications anywhere at the right time. The device is programmed to alert the patient when the doses due time occurs. The medication dispensing device of the present invention comprises essentially a plurality of cartridges divided into a plurality of compartments, a plurality of cylinders to position the cartridges in the device of the present invention, a medication box, a non-taken medication storage component, a portable component, and a plurality of actuators. The portable component can be taken by the patient to any place in order for such patient to adhere to his/her medication doses. The device of the present invention stores the missed dosages in the non-taken medication storage component, and thus prevents the accumulation of such missed doses with a new dose, which has its due time occurred.

Abstract: An apparatus for dispensing pills comprising a pill storage section, a dispensing section located at a lower end of the storage section, an optical sensor, a memory, controller and wireless communication module and a supporting tray for one ring-shaped blister pack. A spring loaded lever is provided as push-out means in line with the respective pills of the blister pack and with the passage opening and can be operated for pushing out the pills to be dispensed through the passage opening. A motorized mechanism is provided as means for rotatable positioning of the blister pack stepwise relative to the part of the apparatus including the push-out means. Optical sensor detects presence of an object such as a person's hand at the passage opening and allows the pills to be dispensed automatically.

Abstract: This invention discloses a smart medicine box, comprising a box body and a cover body attached to an upper portion of the box body, wherein the box body is provided with continuous medicine bags for use with the same. The continuous medicine bags are connected with one another in a point break manner. The box body is provided with a medicine taking port at one side thereof. The cover body is provided with a detection head, a PCB board and a power source, and the detection head is close to the side of the medicine taking port on the box body. The medicine bag is provided with a detection zone to cooperate with the detection head. The smart medicine box has the following advantages: medicine bag tracking can be implemented according to a predetermined medication plan by means of encapsulating medicines taken by the patient each time.

Abstract: A neonatal enteral feeding system for delivering neonate fluid is disclosed. The system includes a cooling unit for cooling the breast milk before, during and after a feeding cycle to mitigate unwanted bacterial growth and reduction of fat content in the breast milk. The system also includes a warming unit for heating the cold breast milk to a temperature above room temperature (preferably, standard body temperature) so that the neonate can focus his or her energy on healing, growth and digestion instead of heat generation. Additionally, the system has a peristaltic pump which draws the breast milk from a bottom side of the container and the container is vented so as to be capable of delivering all of the breast milk in the container to the neonate.

Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.

Abstract: A method of forming dual melamine/acrylic walled microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the use of select (meth)acrylate monomers and/or oligomers and/or select self-condensing melamine resins.

Abstract: Described herein are compositions that include a saline solution and reactive oxygen species. Specifically, the composition may include a saline solution, reactive oxygen species, an emollient, and a pH modifier. Also provided is a gel composition that includes a rheology agent. Also provided are methods of making and using the compositions.

Abstract: Described herein, are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride and a pyrophosphate salt. Also described are external personal care compositions comprising the complexes, and uses thereof.

Abstract: Provided is a powdered tobermorite-type calcium silicate-based material capable of demonstrating high oil absorption. The powdered tobermorite-type calcium silicate-based material is characterized in that (1) a molar ratio of SiO2/CaO in the material is 1.5 or more, and (2) a cumulative pore volume having a pore size of 3.6 nm to 200 nm in the material is 0.9 cc/g or more, and a cumulative pore volume having a pore size of 3.6 nm to 5000 nm is 2.6 cc/g or more.

Abstract: Provided are skin care compositions that are useful as SPF and UV absorption boosters in formulations containing inorganic metal oxides. The compositions comprise (a) 0.1 to 20 weight % inorganic metal oxide particles, based on the weight of the composition, wherein the inorganic metal oxide particles comprise ZnO and TiO2, and wherein the ratio of ZnO to TiO2 is from 1:10 to 10:1, (b) 0.1 to 15 weight % copolymer particles dispersed in an aqueous medium, wherein the copolymer particles comprise polymerized units derived from (i) 0.1 to 20 weight % of phosphorus acid monomers, and (ii) 80 to 99.9 weight % of comonomers, and (c) a dermatologically acceptable carrier. Also provided are methods of protecting skin from UVA and UVB damage comprising topically administering such compositions to the skin, and methods of boosting the SPF or UV absorption of a sunscreen composition containing inorganic metal oxide particles comprising including such copolymer particles in the composition.

Abstract: An anhydrous antiperspirant composition includes a) an antiperspirant active; b) a perfume; and c) a microcapsule comprising a shell and a core, wherein the shell comprises a polymerized acrylate amine; wherein the composition has less than about 100 ppm of a residual metal catalyst and/or metal ion.

Abstract: The present disclosure is directed to alcohol-based anti-adherent compositions that do not adhere to or attract Gram-negative and Gram-positive bacteria once it is applied to a surface and dried. The composition may include as anti-adherent agents, hydrophilic film-formers such as cellulosics, gums, acrylates, nonionic polymers, and anionic polymers. Examples of anti-adherent agents include Hydroxypropyl methylcellulose, Cellulose gum, Acacia Senegal Gum; Polyacrylate Crosspolymer-11, VP/Dimethylaminoethylmethacrylate/Polycarbamyl Polyglycol Ester; Acrylates/Vinyl Neodecanoate Crosspolymer, hydroxypropyl methylcellulose, Hydroxypropylcellulose, Methylcellulose, Propylene Glycol Alginate, Polyacrylate Crosspolymer-6, VP/Polycarbamyl Polyglycol Ester, Acrylates/Steareth-20 Methacrylate Copolymer; Acrylates Copolymer, and any combination thereof. The anti-adherent may be applied to surfaces using a vehicle such as a wipe.

Abstract: An oral care composition is provided. The composition comprises (a) a first component comprising an amine fluoride; and (b) a second component comprising an acidic polymer; wherein the amine fluoride and acidic polymer have respective first and second reactive groups which are arranged to react together to form a cross-linked copolymer of the amine fluoride and acidic polymer when the composition is applied to an oral cavity.

Abstract: The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium: —at least water, —at least alkylcellulose, —at least one first hydrocarbon-based non-volatile oil, chosen from: —C10-C26 alcohols, preferably monoalcohols; —optionally hydroxylated monoesters, diesters or triesters of a C2-C8 monocarboxylic or polycarboxylic acid and of a C2-C8 alcohol; —esters of a C2-C8 polyol and of one or more C2-C8 carboxylic acids, at least one second non-volatile oil chosen from silicone oils and/or fluoro oils or hydrocarbon-based oils other than the said first oil; at least one particular wax; at least one gemini surfactant of particular formula (I).

Abstract: Oral and dental care and cleaning agents and methods that employ the agents are provided herein. In an embodiment, an oral and dental care and cleaning agent includes a polyol derivative of arginine. In another embodiment, a method includes the steps of supplying a toothbrush having a brush head and applying an agent to the brush head, wherein the agent includes a polyol derivative of arginine. Teeth are cleaned using the agent on the brush head.

Abstract: The present invention relates to a composition for dyeing keratin fibers, comprising (a) at least one direct dye; and (b) at least one sulfone compound represented by the following formula (I): wherein each of R1 and R2 independently denotes a monovalent C1-30 aliphatic group or a monovalent C6-30 aromatic group, which may optionally be substituted with at least one substituent; or R1 and R2, together with the sulfur atom which they are binding, form a 3-10 membered ring which may optionally be substituted with at least one substituent. The composition according to the present invention is a one-part composition and can prevent or reduce skin staining by the direct dye on the skin such as the scalp, while providing the keratin fibers with good cosmetic effects such as good coloring properties.

Abstract: The invention relates to a process for dyeing keratin fibers by treating said fibers with i) at least one aromatic compound comprising a hydrocarbon-based polycycle comprising at least 10 carbon atoms, at least one of the rings of which is aromatic, ii) at least one indol(in)e compound; optionally iii) at least one metal salt, iv) at least hydrogen peroxide or at least one hydrogen peroxide-generating system and v) at least one basifying agent; to a dye composition comprising ingredients i) and ii), and optionally iii) to v) as defined previously and to a kit comprising ingredients i) to v) as defined previously. This hair dyeing process makes it possible to obtain better colorings which are more uniform, chromatic and long-lasting and which do not impair the cosmetic properties of the keratin fibers, and prevents changing of the color associated with the presence of indol(in)e derivatives.

Abstract: The disclosure relates to compositions and methods for removing cosmetic films and makeup compositions from keratinous fibers. Compositions comprise at least one low-viscosity, low-volatility silicone. Methods comprise applying the compositions to keratinous fibers.

Abstract: There are described alkoxy-silanes compounds and related condensation products as cosmetic raw materials and for coating cosmetic powders; synthesis processes of such compounds and condensation products and production of coated cosmetic powders. Said cosmetic powders can be used for preparing cosmetic products such as anhydrous products for face/eyes/lips, cosmetic pencils and face/eyes emulsions.

Abstract: The invention relates to a mixture composition comprising rhamnolipids, to a process for its preparation, to its use for producing formulations and to formulations comprising this mixture composition.

Abstract: The present invention relates to a PEG free, stable, low viscosity classic oil-in-water emulsion and the use and preparation thereof. The oil-in-water emulsion comprises, A) a primary emulsifier selected from alkyl polyglucosides and long chained polyglycerol esters, B) a secondary emulsifier selected from short chained polyglycerol esters and short chained sorbitan esters, and optionally a thickener if the amount of secondary emulsifier is below 2.5 wt. %. The emulsion is a classic emulsion and can be sprayable. The emulsion is suitable to prepare spray or foam emulsion products with good application effect.

Abstract: The invention is directed to methods of treating dermatological conditions, including cosmetic treatments intended to moisturize the epidermis, improve the firmness of the dermis, combat ageing of the skin. The methods include application of cosmetic or dermatological compositions containing mannoproteins as an active ingredient and/or adjuvant, to the use of said cosmetic or dermatological compositions and to cosmetic treatment methods.

Abstract: Microfibrous cellulose (MFC) broths are provided having improved performance as compared to wet cake microfibrous cellulose (MFC) and powdered microfibrous cellulose (MFC). In embodiments, compositions having an effective amount of an MFC broth and an effective amount of a surfactant have an improved yield value as compared to a composition having a surfactant and a wet cake MFC, a powdered MFC, or a combination thereof at the same concentration as the MFC broth. Also, methods are provided for improving the yield value of surfactant compositions by adding an effective amount of a microfibrous cellulose broth to an effective amount of surfactant to provide a surfactant composition having a yield value that is higher than a composition having the surfactant and a wet cake MFC, a powdered MFC, or a combination thereof at the same concentration as the microfibrous cellulose broth.

Abstract: The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium: —at least water, —at least alkylcellulose, —at least one first hydrocarbon-based non-volatile oil, chosen from: —C10-C26 alcohols, preferably monoalcohols; —optionally hydroxylated monoesters, diesters or triesters of a C2-C8 monocarboxylic or polycarboxylic acid and of a C2-C8 alcohol; —esters of a C2-C8 polyol and of one or more C2-Cs carboxylic acids, —at least one second non-volatile oil chosen from silicone oils and/or fluoro oils or hydrocarbon-based oils other than the said first oil; —at least one wax; —at least one hydrophilic gelling agent chosen from nonionic associative polymers of polyurethane type, preferably polyoxyethylenated; —preferably at least one surfactant, preferably non-ionic.

Abstract: Described herein is a silicone replacement for use in a personal care formulation comprising a mixture of at least one polymeric ester and at least one non-polymeric ester. The polymeric ester is an esterification reaction product of (i) at least one first dicarboxylic acid, (ii) at least one first monofunctional alcohol or monofunctional carboxylic acid and (iii) glycerin or derivatives thereof. The non-polymeric ester is an esterification reaction product of (i) at least one second dicarboxylic acid and (ii) at least one second monofunctional alcohol, wherein the replacement is substantially free of silicone. As described is a personal care formulation that is substantially free of silicone, wherein the formulation comprises a silicone replacement consisting substantially of a mixture of at least one polymeric ester as described above, and a non-polymeric ester as described above. Related methods are also described.

Abstract: The present disclosure relates to methods of preparing cosmetic compositions by mixing together two different mascara formulations. The starting mascara formulations may contain the same or different ingredients, and they may differ in viscosity and/or in the melting points of their ingredients, such as their waxes.

Abstract: A stable liquid pharmaceutical composition comprising an aqueous solution of a pharmaceutically acceptable salt of acid addition of trazodone, characterized in that said pharmaceutical composition has a pH value between 5.0 and 6.0, and comprises at least two cosolvents selected from the group comprising glycols and polyglycols.

Abstract: Disclosed are an anionic drug-containing polymeric micelle particle comprising: an anionic drug as an active ingredient; a cationic lipid; and an amphiphilic block copolymer, wherein the anionic drug forms a complex with the cationic lipid, and the complex is entrapped in the micelle structure of the amphiphilic block copolymer, and a method for preparing the same. The particle may increase stability of the anionic drug in blood or in a body fluid, and it may enable intracellular delivery to improve efficacy of anionic drugs.

Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.

Abstract: An object of the present application is to provide an orally-disintegrating tablet having excellent tablet hardness and disintegrability, and including a disintegrative particulate composition. This invention relates to a disintegrative particulate composition comprising the four components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component other than the acid-type carboxymethylcellulose, an excipient of a sugar or sugar alcohol, and crystalline cellulose; and to an orally-disintegrating tablet, including the disintegrative particulate composition and a medicinal ingredient.

Abstract: The invention provides a controlled release oral solid formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levodopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric coated polymer; and (b) a decarboxylase inhibitor component.

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.

Abstract: Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 5 to 7 hours or longer, followed by an ascending release rate. When administered at night the composition provides early morning improvement in symptoms of ADHD and sustained improvement over a period of at least 12 hours.