Abstract: In general, according to one embodiment, one aspect of the apparatus comprising a sensor configured to acquire biological signals of a user, the biological signals including first signals and second signals, reliability of the first signals being relatively higher than reliability of the second signals, and a controller configured to activate an alarm, if a ratio of a time period of first signals to a time period of the biological signals is less than a first threshold.

Abstract: A Wearable Cardioverter Defibrillator (WCD) system comprises an electrode assembly with a permeable ECG electrode and a moisture barrier. In some embodiments, the moisture barrier is configured to reduce drying out of the permeable ECG electrode to improve performance of the WCD system. In a further enhancement, some embodiments of the electrode assembly also include a pillow structure positioned on a non-skin-contacting surface of the electrode assembly to comfortably reduce movement artifact or noise in the received ECG signal.

Abstract: An exemplary methodology, procedure, system, method and computer-accessible medium can be provided to determine one or more particular frequencies of cross-relaxation between at least one molecule and at least one particular compound determine a chemical exchange based on magnetic resonance data using a further frequency which is different from the one or more particular frequencies, and derive particular information about the anatomical region of interest based on the chemical exchange.

Abstract: A sensing apparatus for measuring at least one parameter includes at least one sensor for detecting at least one parameter and outputting a signal representative of the parameter. The sensing apparatus includes a memory for storing data and computer instructions and a communication component configured to transmit data representative of a value associated with the at least one parameter. A processor of the sensing apparatus communicates with the at least one sensor, the memory and the communication component. The processor receives output signals from said at least one sensor, and calculates at least one parameter based on computer instructions stored in the memory. The parameter is formatted in a human interface device (HID) compliant protocol, and provided to the communication component, which transmits the at least one HID compliant parameter value to a remote processing device.

Abstract: The invention relates to a device for superimposing known patterns, characteristic of a region, on (real) images of said region. The device comprises, a memory in which patterns are stored, which are representative of a selected region, of known position and orientation with relation to a common reference and processing means, for determining a pattern representative of the selected portion in the memory, on receipt of the designation of at least one portion of an observed image of the selected region, taken at a selected angle and at least one representative attribute of said region, taking account of the attribute selected, then superimposing the determined pattern on the selected portion of the image taking account of the selected angle.

Abstract: A wearable device includes at least one sensor for obtaining a unique identifier from the wearer when the wearer and for transmitting the unique identifier to one or more computer processors for use in determining whether the wearer is a particular individual. The wearable device may also include a wireless communications device for transmitting a signal (e.g., to a remote computing device) that confirms the identity of the wearer as the particular individual. A remote computing device, or other device, or individual, may then, based at least in part on receiving the signal, grant wearer access to a computer program, computing system, and/or a particular physical space.

Abstract: A system and technique are presented, for use in remote sensing of acoustic and/or mechanical vibration data from an inspection region.

Abstract: The methods disclosed herein enable calculating otoacoustic emission (OAE) pressure independent of the acoustic load imposed by the ear canal and the OAE probe measurement system, e.g., for hearing tests. The OAE pressure is calculated in a form of either the first outgoing wave at the eardrum, referred as emitted pressure level (PEPL), or as a Thvenin-equivalent OAE source pressure level (PTPL) at the eardrum, as derived from a simple tube model of an ear canal. In both methods the OAE sound pressure level (PSPL), ear canal reflectance (REC), OAE probe source reflectance (RS), and one-way ear canal delay (?) are measured at the entrance of the ear canal with the OAE probe. In contrast to PSPL, both methods result in an emission pressure that is not confounded by the effects of the residual ear canal space or the impedance of the OAE measurement system.

Abstract: A method for obtaining blood glucose concentration using near infrared spectroscopy (NIR) data is provided. The method includes obtaining, by an independent component analysis (ICA) temporal module, orthogonal pure spectra from human NIR spectra; performing, by a processing module, one or more preprocessings and drift removal on the human NIR spectra and the orthogonal pure spectra to obtain preprocessed spectra; and obtaining, by a regression block, the blood glucose concentration from the preprocessed spectra.

Abstract: A system and method of extending the life of a battery. The system may include a display device and a transceiver. The transceiver may include the battery. The transceiver may be configured to perform a battery level reading function to determine a battery level of the battery. The transceiver may be configured to time performance of the battery level reading function such that it does not occur at the same time as a period of high current demand on the battery. The transceiver may be capable of executing concurrently two or more of the functions, and the transceiver may be configured to avoid executing concurrently one or more of: (a) a number of functions greater than a maximum number of functions; (b) functions including one or more high current demand functions; and (c) two or more functions that would have a combined current demand higher than a current demand threshold.

Abstract: A blood glucose prediction method comprising: acquiring a PAS signal by irradiating light to skin of the body, obtaining a photoacoustic image of the skin from the PAS signal, selecting at least one measurement location based on the photoacoustic image; and predicting the blood glucose based on a photoacoustic spectrum of a PAS signal corresponding to the at least one measurement location among the PAS signals, a blood glucose sensor, and a blood glucose prediction system are provided.

Abstract: Methods and apparatus for providing multi-stage signal amplification in a medical telemetry system are provided.

Abstract: A system and method for assessing blood flow include: an ocular lens; a light source; a digital video camera; a biosensor; a trigger; and a computer. The ocular lens is for viewing a fundus of an eye. The light source is for illuminating the fundus. The digital video camera is for imaging the fundus. The biosensor is for sensing a pulse waveform. The computer is configured for: recording input frames and pulse waveform data in response to an input from the trigger; defining a low-pass frequency and a high-pass frequency from the pulse waveform data; stabilizing the input frames; enhancing contrast of the input frames; separating the input frames into sub-channels; conducting eulerian video magnification for color amplification using the inputs of image sampling rate, the low-pass frequency, the high-pass frequency, and an amplification factor; reconstructing the sub-channels into output frames; and combining the output frames with the input frames.

Abstract: An analyte sensor may include a sensor housing and an analyte indicator element embedded within and/or covering at least a portion of the sensor housing. The analyte indicator element may include a porous base having an interior surface and an exterior surface. The analyte indicator may include a catalytically active material disposed on at least one of the interior and exterior surfaces of the porous base, in which the catalytically active material catalyzes the degradation of reactive oxygen species. The analyte indicator may include a polymer unit polymerized onto or out of the porous base and an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit.

Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a rotatable element that actuates the deployment actuator.

Abstract: An exemplary blood sampling tool/device can be provided with which, even when a small amount of sample is collected, such amount of sample can be collected in a state suitable for a later analysis. The exemplary blood sampling tool/device can comprise, e.g., a pipette tip-shaped blood sampler having openings at an upper part and a lower part having an interior space for aspirating and retaining blood by the capillary action. This exemplary tool/device can also comprise a blood container having a hydrophilically treated inner wall and bottom, and having a protrusion provided at the bottom that is able to accommodate the blood collected by the blood sampler. A sealing lid can also be provided for sealing the blood container.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: A process of correlating cognitive response to a stimulus is provided by collecting biometric data with a camera having a microprocessor for modifying an image by localizing eyes within a face in the image, collecting neural activity data from a subject while exposed to a stimulus and mapping neural activation in response to the stimulus onto neuronal structure of a subject brain. A unique three-dimensional cognitive engram representative of the neural activity caused by the stimulus is then constructed. The cognitive engram is then compiled in a database containing a plurality of engrams, each of which is associated with a different stimulus for interpreting cognitive response. Then, each unique three-dimensional cognitive engram stored in the database is correlated with the biometric data representative of a stimulus.

Abstract: Disclosed herein are a system and a method for evaluating mental disease treatment contents using complex biometric information, which can provide contents of good quality for recovery and treatment of a psychiatric patient, can develop customized treatment contents, and provide objective and logical evaluation information through the treatment contents.

Abstract: Provided are a grip strength detection mechanism, an exercise apparatus provided with the same, and a method for using the same. The exercise apparatus is provided with: a grip part 12 comprising a cylindrical flexible member; sealing members 13, 16 which seal both ends of the grip part 12 to form a deformable sealed space 18 which is surrounded by the grip part 12; a pressure sensor 28 which is held by the sealing member 16 and detects the pressure within the sealed space 18; and a control unit which detects, as the pressure within the grip part, a reference grip strength which is not more than the maximum grip strength detected by the pressure sensor 28 in order to display, on a display unit 7, the grip strength of a user gripping the grip part 12.

Abstract: Provided are methods of assessing and/or training cognitive fitness. Aspects of the instant methods generally relate to identifying and observing neural activity that underlies an event occurring in response to the stimulus or sequence of stimuli of a cognitive task performed by a subject. As such, the instant methods generally include presenting a cognitive task to a subject that includes a stimulus or sequence of stimuli, and monitoring the neural activity of the subject during performance of the cognitive task. Monitoring of such neural activity may be used, at least in part, to determine a neural performance level of a subject which may, in turn, be used in various ways including e.g., as an assessment of cognitive fitness, to tailor a subsequently presented cognitive task to train the cognitive fitness of the subject, etc. Systems and computer readable media for practicing the methods of the present disclosure are also provided.

Abstract: An apparatus for generating a quantifier of cognitive skills in an individual includes a user interface, a memory to store processor-executable instructions, and a processing unit communicatively coupled to the user interface and the memory. Upon execution of the processor-executable instructions by the processing unit, the processing unit is configured to: render a first instance of a task with an interference at the user interface, requiring a first response from the individual to the first instance of the task in the presence of the interference and a response from the individual to at least one evocative element. One or more of the first instance of the task and the interference comprises the at least one evocative element. The user interface is configured to measure data indicative of the response of the individual to the at least one evocative element, the data comprising at least one measure of emotional processing capabilities of the individual under emotional load.

Abstract: An electronic device for measuring hydrature, and a method for the same are disclosed. The electronic device includes a display, a capacitive sensor and a processor implementing the method, including setting an attribute of a capacitive sensor using a first value, acquiring a first data measurement from the capacitive sensor in when an external object contacts a display and determining that a touch input has occurred based on the first data, detecting whether the determined touch input satisfies a prespecified condition, setting the operational attribute of the capacitive sensor using a second value when the prespecified condition is satisfied, acquiring a second data measurement from the capacitive sensor while the external object contacts the display when the at least one operational attribute is set using the second value, and determining a hydrature value associated with the external object at least based on the acquired second data measurement.

Abstract: A computer-implemented method can include receiving a first image input from a user, determining values of biological properties of the user, determining a first formulation, controlling a plurality of servomotors, receiving a second image input from a user, determining a second value of one of the biological properties of the user, comparing the first and second values, changing another of the values, determining a second formulation, and again controlling the plurality of servomotors. The image inputs can include images of the users skin. The values can be representative of a sensitivity of the user's skin to one or more materials and a current level of irritation of the user's skin. The formulations can contain a plurality of materials and can be configured to inhibit irritation of the user's skin based on the values of the biological properties of the skin.

Abstract: An electronic apparatus, system, and method for providing body posture health information are provided. The method includes the steps of: calculating a posture data cluster based on signals detected by an inertial sensor disposed on a human body; comparing the posture data cluster with a plurality of preset posture data clusters individually to determine whether the posture data cluster matches one of the preset posture data clusters; if it matches one of the preset posture data clusters, generating a feedback message; calculating a plurality of muscle status indexes based on signals detected by electromyography sensors disposed on the human body; comparing the muscle status indexes with corresponding preset muscle status indexes individually to determine whether one of the muscle status indexes is abnormal; providing suggestion information in response to at least one of the muscle status indexes being abnormal; and displaying a multimedia corresponding to the suggestion information.

Abstract: A computer system and method is disclosed as a support structure for patients with hypertension or prehypertension to encourage life style changes leading to dietary control, increase exercise and blood pressure control. The method includes automated messages and responses delivered in real time to encourage appropriate actions by the patient. A diary feature is provided for user input of various relevant parameters, such as foods consumed, exercise activities, body weight, blood pressure, and heart rate. The computer system and method may be implemented on a mobile computing device, such as a smart phone or wearable, a conventional personal computer, or a web service. Most functions will be provided on the mobile device, but some housekeeping and data visualization functions may be limited to the personal computer or web service implementations.

Abstract: The assisted capacity device calculator for myocardial infarction system is intended to assist a user during, or recently having had, a myocardial infarction and is intended to aid to help all people, especially those who have are susceptible to having myocardial infarctions, i.e., heart attacks. The apparatuses of the system are predominately mobile but can also be stationary and can be programmed by receiving and selecting pre-set commands to operate and assist a user but is particularly adapted for use when a user is having symptoms of a myocardial infarction. Particularly, the system is capable of prompting the user to respond to myocardial infarction symptoms, by answering various symptom questions, and if necessary, activate electrocardiographic (ECG) components, to test for electro cardio activity and/or a blood analyzer sensors to test for cardiac markers.

Abstract: A biological information analysis device includes: an indicator extraction unit configured to extract, from data regarding blood pressure waveforms consecutively measured by a sensor configured to be worn on a body part of a sleeping user and to be capable of non-invasively measuring a blood pressure waveform for each heartbeat, an indicator that is related to the functionality of respiratory organs of the user, based on characteristics of the blood pressure waveforms; and a processing unit configured to perform processing that is based on the indicator thus extracted.

Abstract: A biological information analyzing device includes: an indicator extraction unit that converts, into a frequency spectrum, time series data of a blood pressure waveform continuously measured by a sensor that is worn on a user's body and can non-invasively measure the blood pressure waveform for each of heartbeats, and extracts an indicator based on a strength of a prescribed frequency component in the frequency spectrum; and a processing unit that carries out a process based on the extracted indicator.

Abstract: The present disclosure provides methods of identifying a loosened joint implant by analyzing acoustic emissions from the implant. The present disclosure further provides apparatuses for measuring acoustic data and analyzing acoustic emissions from a joint implant.

Abstract: Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue.

Abstract: The invention is related to a device to sense the pulse on a wrist of a subject and to arrive at the health status of the said subject by capturing the pulse in real time; analyzing the pulse based on time-frequency properties of the pulse signal and Vata, Pitta and Kaphahumors of the subject. The device reliably detects and captures noise free pulse characteristics of a subject at the appropriate locations of the subject's wrist with minimal positional error in a user friendly way with minimal reliance on the expertise of the person measuring the pulses. The device facilitates the analysis of the pulses and provides a comprehensive diagnostic system based on the pulse characteristics, visual features, responses of a subject to structured queries to arrive at the tridosha levels in a subject.

Abstract: Sensing devices including sensors such as flexible and stretchable fabric-based pressure sensors, may be associated with or incorporated in garments, such as socks, intended to be worn against a body surface (directly or indirectly). Specific manifestations of a sensing system incorporated in a sock substrate are described in detail. Dedicated electronic devices interface electrically with sensors through intermediate conductive traces, optional conductive bridges, conductive contacts provided in a mounting tab.

Abstract: Splints for diagnostic and/or therapeutic purposes are disclosed. In one aspect, the present disclosure relates to a splint system for diagnostic and/or therapeutic functions for a patient with a vascular impairment. In one embodiment, the splint system includes a splint having: a leg supporting portion and a foot supporting portion, that are configured to support and secure the leg and foot of the patient; a locally and/or remotely controllable portion for setting a dorsiflexion angle of the foot of the patient, including electrical and/or mechanical controls and one or more actuators for setting of the dorsiflexion angle, for providing treatment to improve vascular function; and a plurality of physiological parameter sensors for measuring physiological parameters of the leg and/or foot of the patient, wherein the physiological parameters are associated with vascular function in the leg and/or foot of the patient.

Abstract: Provided is a flex-PCB catheter device that is configured to be inserted into a body lumen. The flex-PCB catheter comprises an elongate shaft, an expandable assembly, a flexible printed circuit board (flex-PCB) substrate, a plurality of electronic components and a plurality of communication paths. The elongate shaft comprises a proximal end and a distal end. The expandable assembly is configured to transition from a radially compact state to a radially expanded state. The plurality of electronic elements are coupled to the flex-PCB substrate and are configured to receive and/or transmit an electric signal. The plurality of communication paths are positioned on and/or within the flex-PCB substrate. The communication paths selectively couple the plurality of electronic elements to a plurality of electrical contacts configured to electrically connect to an electronic module configured to process the electrical signal. The flex-PCB substrate can have multiple layers, including one or more metallic layers.

Abstract: A stand-on physiological sensor (e.g. floormat) measures vital signs and various hemodynamic parameters, including blood pressure and ECG waveforms. The sensor is similar in configuration to a common bathroom scale and includes electrodes that take electrical measurements from a patient's feet to generate bioimpedance waveforms, which are analyzed digitally to extract various other parameters, as well as a cuff-type blood pressure system that takes physical blood pressure measurements at one of the patient's feet. Blood pressure can also be calculated/derived from the bioimpedance waveforms. Measured parameters are transmitted wirelessly to facilitate remote monitoring of the patient for heart failure, chronic heart failure, end-stage renal disease, cardiac arrhythmias, and other degenerative diseases.

Abstract: A conformal tattoo biosensor device includes a pattern of sensor regions formed of a conductive polymer. In embodiments, the conductive polymer may have up to six sensor regions. The pattern is electrically connected to a contact region which is electrically connectable to a wearable signal monitor. The monitor is suitable for transmitting ECG, EEG, or EMG signals. In a monitoring system, the monitor wirelessly transmits signals to a mobile communication device for processing. The mobile communication device transmits signals to a monitor network which may include medical personnel and caregivers. A network module may allow automatic medical alerts, monitoring, and further signal processing.

Abstract: A wearable device includes: a light source, a sensor and a processor. The light source selectively operates in an illuminating mode or a non-illuminating mode, and generates an auxiliary light passing through a physical body in the illuminating mode. The sensor captures detecting images from the physical body, wherein the detecting images include at least one illuminating image captured while the light source is in the illuminating mode, at least one pre-illuminating image captured before the illuminating image is captured while the light source is in the non-illuminating mode, and at least one post-illuminating image captured after the illuminating image is captured while the light source is in the non-illuminating mode. The processor generates physiological information of the physical body according to the illuminating image, the pre-illuminating image and the post-illuminating image.

Abstract: A system and method adapted for at least one health-related application selected from physiological monitoring, defibrillation, and pacing in the presence of electromagnetic interference (EMI) using the time-domain features of EMI patterns and physiological waveforms. The invention enables EMI detection and identification in a plurality of signals, including various physiological signals, which may contain both physiological information and EMI-generated artifacts. The system utilizes adaptive and versatile modular architecture with a set of modules for various filtering, conditioning, processing, and wireless transmission functions, which can be assembled in different configurations for different settings. In some preferred embodiments, the method and system of this invention are incorporated into (or attached to) an external cardiac defibrillator/monitor or cardiac pacing device.

Abstract: Methods and apparatuses for determining an analyte value are disclosed.

Abstract: Blood pressure signals are reconstructed from PhotoPlethysmoGraphy (PPG) signals by: receiving PPG signals including systolic, diastolic and dicrotic phases; and determining first and second derivatives of the PPG signals and: a first set of values indicative of lengths of the signal paths of the PPG signal, the first derivative and the second derivative thereof in the systolic, diastolic and dicrotic phases; a second set of values indicative of relative durations of the PPG signal and the first and second derivatives thereof in the systolic, diastolic and dicrotic phases; and a third set of values indicative of the time separation of peaks and/or valleys in subsequent waveforms of the PPG signal. Reconstruction also includes applying artificial neural network processing to the first, second and third set of values. The artificial neural network processing includes artificial neural network training as a function of blood pressure signals to produce reconstructed blood pressure signals.

Abstract: A method, system and computer-usable medium for training an information processing system to utilize personalized audio selection to facilitate achieving a target state comprising: identifying target states for a plurality of users; identifying a type of user for each of the plurality of users; identifying a plurality of sets of audio selections for each of the plurality of users; monitoring reactions by each of the plurality of users to each of the plurality of sets of audio selections; and, associating a set of audio selections from the plurality of sets of audio selections with a type of a user based upon the reactions by the plurality of users to the set of audio selections.

Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Abstract: This terminal device is provided with: an acquisition unit which receives, from a server, information displayed on a display device used for medical treatment or care, and stores the received information in a storage unit; and a display control unit which displays the information on the display device. When a display stop condition, which indicates the likelihood that there is a difference between information stored in the server and information stored in the storage unit, is satisfied, the display control unit stops the display of at least information about biological information on a facility user who is a person requiring the medical treatment or care, among the information on the display device.

Abstract: A medical device includes a temperature sensor configured to deliver a temperature signal and an optical sensor configured to deliver an optical signal. The medical device also includes a microcontroller configured to receive the temperature signal and the optical signal. The microcontroller is configured to calculate, in real-time, a body temperature, a pulse rate, a respiratory rate, and a blood oxygen concentration based on the received temperature signal and the received optical signal. The medical device also includes a display configured to display the body temperature, the pulse rate, the respiratory rate, and the blood oxygen concentration of a patient.

Abstract: A region of interest first displayed on a model image of an object is mapped onto a corresponding location on the object defined relative to determined locations of predefined features. A source of radiation is set so that the region of interest on the object is irradiated.

Abstract: The invention proposes to combine spectral image data with non-spectral image data in order to overcome limitations of the different data taking methods. Results from the methods are preferably combined as functions of spatial frequency so that spectral image data provide high accuracy at low frequencies, whereas the non-spectral image data helps reducing the noise at high frequencies. The invention enables a range of applications in different fields of X-ray imaging such as improved tissue contrast and tissue characterization.

Abstract: The present invention relates to an apparatus (10) for imaging an object. It is described to position (210) an X-ray detector relative to at least one X-ray source such that at least a part of a region between the at least one X-ray source and the X-ray detector is an examination region for accommodating an object. In a first mode of operation, with the at least one X-ray source a first focal spot is produced (220), such that at least some first X-rays produced at the first focal spot pass through a first grating of an interferometer arrangement, the first grating positioned at a first position, and such that the at least some first X-rays pass through a second grating of the interferometer arrangement, the second grating positioned at a second position. In the first mode of operation, the at least some first X-rays are detected (230) with the X-ray detector at a detector position.

Abstract: The disclosure provides a method and device for performing three-dimensional blood vessel reconstruction using angiographic images. The method includes an acquisition step that acquires a first two-dimensional image of the blood vessel in the first projection direction and a corresponding reconstructed three-dimensional model of the blood vessel.

Abstract: Computed tomography perfusion (CTP) is used in a method to identify cancerous lesions having genetic mutations and treat them accordingly. Also, CTP values are used to distinguish primary versus metastatic lesions. For example, pulmonary blood flow is identified as one biomarker for EGFR and KRAS genetic mutations in lung cancer, lesion having dual-input pulmonary blood flow exceeding a threshold (e.g., 103 ml/min/100 mL with sensitivity 100% and specificity 62%) are determined as having mutations. The CTP values are calculated using a lesion region-of-interest (ROI) placed to include the area of maximum perfusion intensity within the lesion bass and surrounding blush, while avoiding regions of perfusion inhomogeneity (e.g., due to necrosis). In certain implementations, instead of a binary determination, the method can generate probabilities associated with respective alternatives (e.g.