Abstract: A method for making a polymer with a porous layer from a solid piece of polymer is disclosed. In various embodiments, the method includes heating a surface of a solid piece of polymer to a processing temperature and holding the processing temperature while displacing a porogen layer through the surface of the polymer to create a matrix layer of the solid polymer body comprising the polymer and the porogen layer. In at least one embodiment, the method also includes removing at least a portion of the layer of porogen from the matrix layer to create a porous layer of the solid piece of polymer.

Abstract: Embolic protection elements are integrated with a catheter or access sheath for any catheter. A catheter with an integrated embolic protection element comprises a catheter shaft, an embolic filter slidably mounted on a distal portion of the shaft, a proximal stop for limiting the proximal movement of the embolic filter, and a distal stop for limiting the distal movement of the embolic filter. The filter comprises a porous mesh material defining a collection chamber for captured emboli and has a collapsed and a deployed configuration. The filter may be collapsed by an access sheath used with the catheter. An access sheath may comprise a tubular main body and an embolic filter mounted on the distal portion of the tubular main body. The embolic filter may evert into the central lumen of the sheath or may be constrained on the exterior of the sheath with a larger diameter outer tube.

Abstract: Vascular filters and deflectors and methods for filtering bodily fluids. A blood filtering assembly can capture embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature. A blood deflecting assembly can deflect embolic material dislodged or generated during an endovascular procedure to inhibit or prevent the material from entering the cerebral vasculature.

Abstract: Apparatus and methods are described including inserting an implantable device (20) into a blood vessel of a subject while the implantable device is disposed inside a delivery device and is constrained in a constrained configuration by the delivery device. The implantable device is released from the delivery device into the blood vessel, thereby causing the implantable device to assume a non-constrained configuration by an upstream end of the implantable device radially expanding (120), a central portion (122) of the implantable device radially expanding such that along the central portion of the implantable device the inner surface (24) of the implantable device defines a diverging portion (25) of a conduit (26), and the implantable device forming a folded portion (128) between the upstream end of the implantable device and the central portion of the implantable device. Other applications are also described.

Abstract: A multi-component stent-graft system is provided, which includes a first stent-graft, which is configured to assume radially-expanded and radially-compressed states; and a second stent-graft, which is configured to assume radially-expanded and radially-compressed states. A delivery tool includes an outer tube, in which the first and the second stent-grafts are initially positioned at respective axial sites within the outer tube, in their radially-compressed states without being fixed to each other. Other embodiments are also described.

Abstract: A vascular graft suitable for implantation, and more particular to a vascular graft having an expandable outflow region for restoring patency of the graft after implantation into a body lumen.

Abstract: An ophthalmic lens includes an optic comprising an anterior surface, a posterior surface, and an optic edge extending between the anterior surface and the posterior surface, the optic having an optical axis. The ophthalmic lens further includes a plurality of haptics extending from a periphery of the optic, each of the plurality of haptics including a gusset region, a distal region, and an elbow region connecting the gusset region to the distal region. The gusset region of each of the plurality of haptics extends from the periphery of the optic and spans a portion of the periphery of the optic. In addition, the gusset region of each of the plurality of haptics monotonically increases in thickness with increased distance from the periphery of the optic, while the distal region of each of the plurality of haptics monotonically decreases in thickness with increased distance from the elbow region.

Abstract: An IOL utilizes a haptic formed as a toroid portion configured to fit into a capsular bag of an aphakic eye of a patient. The toroid portion may be separate from an IOL optic and may include a receiving feature for the IOL optic. The toroid portion may be configured for intraoperative fluid-filling for snug fitting at the equator of the capsular bag, in order to immobilize the IOL optic.

Abstract: The present invention is a phakic intraocular lens for implantation between an iris and a crystalline lens. The phakic intraocular lens includes a diffraction grating 5 disposed in a lens central part 2 and having circular, coaxial grooves formed thereon, and a support part 3 disposed outside the diffraction grating 5 and supporting the diffraction grating 5. A hole 6 is formed in the center of the diffraction grating 5.

Abstract: Ophthalmic devices are used to treat a variety of eye conditions. Such devices include intraocular lens (IOL) implants, contact lenses, intraocular telescopes, and the like. Such ophthalmic devices typically include one or more lenses to interact with visible light. According to an aspect of the disclosure, there is provided an ophthalmic device comprising a biocompatible polymer body and a metalens. The metalens is encapsulated by the polymer body. The metalens comprises a substantially transparent substrate and a plurality of subwavelength structures arranged on the substrate in a pattern to interact with visible light. subwavelength structures comprise a dielectric material such as titanium dioxide.

Abstract: An ophthalmic lens includes an optic having an anterior surface with an anterior surface radius of curvature (R1) and a posterior surface with a posterior surface radius of curvature (R2). The anterior surface radius of curvature (R1) and the posterior surface radius of curvature (R2) define a shape factor (X) (where X=(R2?R1)/(R2+R1)) that is greater than zero. The shape factor (X) corresponds to a curve defining shape factor (X) as a function of lens power (P), the curve monotonically decreasing with increased lens power (P).

Abstract: Accommodating intraocular (AIOL) assemblies for enabling post implantation in situ manual selective displacement of an AIOL along a human eye's visual axis relative to stationary anchor points. Axial displacement may be over a continuous range or alternatively at discrete axial stopping positions typically from about 100 ?m to about 300 ?m apart. Novels AIOLs designed to be at least partially folded for facilitating insertion into a human eye through a relatively small incision.

Abstract: A method for performing an ophthalmic procedure on an eye, the eye having a capsular bag in which an intraocular lens (IOL) has been implanted, includes applying energy to a portion of the capsular bag. The applied energy is sufficient to melt the portion of the capsular bag without cauterization such that the portion of the capsular bag adheres to an adjacent portion of the IOL.

Abstract: A collapsible and expandable prosthetic mitral valve includes a stent and a flange. The stent has an inflow end, an outflow end, and a first central longitudinal axis extending from the inflow end to the outflow end in an expanded condition of the prosthetic mitral valve. A valve assembly is disposed within the stent. The flange is formed of a braided mesh and has a body portion coupled to the stent and a flared portion adjacent the inflow end of the stent. A second central longitudinal axis extends through the flared portion in the expanded condition of the prosthetic mitral valve and is offset from the first central longitudinal axis.

Abstract: Prosthetic valve systems for treating a native valve exhibiting regurgitation comprising a support structure in which a separate prosthetic heart valve (THV) can be placed. The support structure can be configured to be positioned at the native valve. After the support structure is deployed at the native valve, a prosthetic valve can be deployed within the support structure. The support structure can comprise a main body formed by formed by a plurality of inner strut members and a plurality of outer strut members, wherein the plurality of inner strut members and the plurality of outer members are coupled together and have gaps located between inner strut members and the outer strut members. Other embodiments are also disclosed.

Abstract: Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Deployment systems and methods for using the deployment systems described herein facilitate accurately and conveniently controllable percutaneous, transcatheter techniques by which the prosthetic heart valves can be delivered and deployed within a patient.

Abstract: Apparatus and methods are described herein for various embodiments of a prosthetic heart valve, delivery apparatus and delivery methods for delivering a prosthetic heart valve to a heart of a patient via a transapical or transvascular delivery approach. In some embodiments, a prosthetic heart valve includes an outer frame coupled to an inner frame and the outer frame is movable between a first configuration relative to the inner frame and a second inverted configuration relative to the inner frame. The valve can be delivered to a heart using an apparatus that includes a delivery sheath that defines a lumen that can receive the prosthetic heart valve therein when the outer frame is in the inverted configuration. Actuation wires are releasably coupled to the outer frame and can be used to help revert the outer frame after the valve is deployed outside of the delivery sheath and within the heart.

Abstract: A delivery device used for delivering a heart valve, a blood vessel stent, and the like. The device includes a first stopper and a connecting unit. The connecting unit is provided opposite to the first stopper and can move relative to the first stopper. The connecting unit includes an axial connecting portion and at least two axial shafts. The axial shaft is connected to the connecting portion and faces the first stopper. The connecting unit is used to form, together with the first stopper, an enclosed and locked space.

Abstract: A native heart valve includes a first leaflet and a second leaflet. The first and second leaflets are arranged into a double-orifice by using the implant to couple a middle scallop of the first leaflet to a middle scallop of the second leaflet. Using at least one clip controller, each clip is opened by deflecting an arm of the clip away from a midline of the implant, and each clip is closed by deflecting the arm of the clip back toward the midline. The first and second clips are opened and closed independently of each other. Other embodiments are also described.

Abstract: Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. Such anchors can include deformable or collapsible structures upon tensioning of a bridging element in a lateral direction, or segmented tubes that can be adjusted by tightening of one or more tethers extending therethrough. Such anchors can be used as a posterior anchor in a blood vessel in implant systems having a tensioned bridging element extending between the posterior anchor and an anterior anchor deployed at another location within or along the body organ. Methods of deploying such anchors, and use of multiple anchors or multiple bridging elements to a single anchor are also provided.

Abstract: A device for improving the function of a heart valve has a first and a second shape. The device comprises two contact points, wherein the device in the first shape exhibits a distance between the two contact points essentially corresponding to a distance between two commissures of the heart valve and the device in the second shape exhibits an increased distance between the contact points. The device is in the first shape arranged for insertion to the heart valve to establish a contact between the contact points and the commissures. The device is transferable from said first shape to said second shape, and the device is in the second shape arranged for extending in abutment with valve tissue throughout a cycle of heart action. The device may change the shape of the heart valve by stretching it between the commissures for improving the ability of the heart valve to close.

Abstract: An annuloplasty ring comprising an elongated curved member defining a ring-shape having an at rest size and shape to fit against the annulus of the mitral valve in a heart, the member having a substantial saddle shape wherein the annular height to width ratio is in the range of 5% to 50%.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include device for chordae tendineae repair. The device may include a flexible cord having a first end and a second end; and a helical wire configured to attach to one of the first end and the second end of the flexible cord and anchor the flexible cord to a leaflet of a heart valve; and a capture device having a channel and configured to clamp the leaflet of the heart valve and deliver the flexible cord through the channel to anchor the helical wire to the leaflet.

Abstract: A medical securing device for securing an implant device, such as a cardiac implant device with a securing member into a tissue, such an annulus of a heart valve comprises a first elongated stem having proximal and distal ends. The distal end of the first stem has a receiving member for receiving the securing member. During a mutual movement of the distal end of the first stem and the receiving member, the distal end of the first stem is configured to introduce with the receiving member the securing member to the implant device to secure the implant device to the tissue with the securing member.

Abstract: A method for treating a male patient suffering from impotence is disclosed. The method comprises the steps of: cutting the skin of the patient, inserting at least one dissecting tool, and dissecting the area of a penile tissue including a blood flow passageway using said dissecting tool. The method further comprises the steps of: placing restriction device in the dissected area, and forming a restricted penile blood flow passageway, wherein the restriction device is adapted to be powered and controlled from outside the patient's body.

Abstract: DBM compositions, methods of making and methods of treatment with the same are provided. The DBM compositions are made from mechanically entangled bone material that does not contain a carrier. The coherent mass of mechanically entangled demineralized bone fibers can be obtained by needle punching with barbed needles, entanglement with water or air jets, or by applying ultrasonic waves to the demineralized bone fibers. A coherent mass of mechanically entangled demineralized bone fibers can also be obtained by application to demineralized bone fibers of moisture, heat and pressure provided by pressure rollers. A method of making a bone material for hydration with a liquid is also provided. The method includes subjecting demineralized bone fibers to mechanical entanglement to obtain a coherent mass of demineralized bone fibers in the absence of a carrier. A method of treating a bone cavity with a mass of mechanically entangled demineralized bone fibers is also provided.

Abstract: The present invention relates to a fenestrated bone graft and a method of preparing cortical bone in thin strips then fully demineralizing it to give it formed flexibility and then creating fenestrations in the cortical bone in a fashion similar to but not identical to skin grafts.

Abstract: An interbody spinal fusion implant includes a top wall, a bottom wall that is spaced apart from the top wall so that a cavity is formed therebetween, and a sidewall extending between the top wall and the bottom wall. At least a portion of the sidewall includes: a row of a plurality of spaced apart outer struts extending between the top wall and the bottom wall, and a row of a plurality of spaced apart inner struts extending between the top wall and the bottom wall, the row of inner struts being set back a distance from the row of outer struts toward the cavity.

Abstract: An intervertebral prosthesis for insertion between adjacent vertebrae includes an upper plate, a lower plate and a core. The core is retained between the upper and lower plates by a retention feature in the form of central projections on the plates and a corresponding opening in the core. The retention feature is designed to allow the plates to slide over the upper and lower surfaces of the core in the anterior/posterior direction and in the lateral direction and to allow the plates to rotate with respect to each other and the core. The retention feature is also designed to prevent contact between the first and second plates during sliding movement of the plates over the core.

Abstract: An expandable intervertebral implant, including an inferior component, including a first plate, a second plate connected to the first plate and including a first plurality of locking apertures, and a third plate connected to the first plate and including a second plurality of locking apertures, a superior component slidingly engaged with the inferior component, including a fourth plate, a fifth plate connected to the fourth plate and including a third locking aperture, and a sixth plate connected to the fourth plate and including a fourth locking aperture, and a locking pin assembly arranged at least partially in the third and fourth locking apertures, and operatively arranged to engage the first and second pluralities of locking apertures to lock the expandable intervertebral implant.

Abstract: The present disclosure provides an expandable spinal implant comprising a plurality of moveable endplates pivotably connect to a housing.

Abstract: An implant including a peripheral frame portion defining a periphery of the body; a first helical bone contacting member attached to the body and disposed within the superior half of the implant; and a second helical bone contacting member attached to the body and disposed within the superior half of the implant. The implant also includes a first support member extending inwardly of the bone contacting member into a central region of the implant; and a second support member extending inwardly of the bone contacting members. The first support member and the second support member are substantially U-shaped and are connected to one another at the bottoms of the two U-shapes in the central region.

Abstract: Methods of inserting and retaining interbody fusion material are disclosed. In some embodiments, the methods include inserting an anchored implant comprising a bone anchoring portion and an engagement portion. A method may also include inserting at least one bone fusion material within a disc space between two adjacent vertebral bodies. In some embodiments, a method includes driving the bone anchoring portion into an outer surface of at least one of the adjacent vertebral bodies and recessing the bone anchoring portion within the outer surface of the at least one adjacent vertebral body.

Abstract: An insertion instrument for expandable spinal implants includes an elongate member, a shuttle, and a worm gear. The elongate member includes a handle portion of a proximal end and an end effector on a distal end, wherein the end effector is configured to be releasably engaged to an expandable spinal implant. The shuttle is slidably disposed within a cavity defined within the end effector and includes a wedged shaped distal end configured to engage an expandable spinal implant. The worm gear is rotatably disposed within the cavity defined in the end effector and is in mechanical communication with the shuttle, such that rotation of the worm gear effectuates movement of the shuttle. Distal movement of the shuttle effectuates articulation of an expandable spinal implant. A method of performing surgery is also disclosed.

Abstract: In one embodiment, a surgical guide structure configured for placement on a resected bone surface includes a body with at least one aperture and an opening. The at least one aperture extends through the body and is sized for placement of a hole formation instrument therethrough. Additionally, the at least one aperture is defined by an inner wall that includes a first portion having a first slope and a second portion having a second slope different from the first slope so that a cross-section of the aperture varies over its depth. The opening is sized and positioned so that when the surgical guide structure is positioned on a first resected surface of a bone, the first resected surface and a second resected surface of the bone are visible through the opening.

Abstract: Features for a powered prosthetic thumb are described. The thumb provides for rotation of a digit that mimics the natural movement possible with a sound thumb. The thumb may attach to a full or partial prosthetic hand or socket on a residual limb. The thumb may include an upper assembly, including a prosthetic thumb digit, rotatably attached to a mount about a pinch axis and a lateral axis. The digit may rotate about only the pinch axis, only the lateral axis, or both the pinch and lateral axes simultaneously. A first actuator may actuate to cause rotation of the digit about the pinch axis. A second actuator may actuate to cause rotation of the digit about the lateral axis. The first and second actuators may be actuated together at appropriate speeds to cause rotation about both the pinch and lateral axes simultaneously. A swaying chassis may be rotatably connected with the upper assembly and a lower assembly about various offset axes to provide for rotation about the lateral axis.

Abstract: A transfemoral prosthetic level socket system for a user's lower limb comprising modular socket components fitted to the individual user's residual limb having a mounting point for an attachment, at least one compliant member attached to at least one stabilizing unit, and at least one second compliant member attached to at least one stabilizing unit wherein the first compliant member and the second compliant member work in cooperation with the stabilizing unit(s) to control bone position and support the limb within the interface.

Abstract: A prosthesis socket having a proximal insertion opening and an inner circumference which at least partially surrounds a limb stump, at least one connection device for a prosthesis component, which is connectable to the prosthesis socket, at least one actuator, by means of which the inner circumference of the prosthesis socket is changeable, and at least one sensor coupled to a control device, wherein the control device is connected to the actuator and activates or deactivates same, depending on the received sensor signals, and to a method for adjusting the inner circumference.

Abstract: A prosthetic liner includes a textile cover having at least first and second regions having different elongation from one another. The first region is in a prestretched configuration in at least one orientation relative to an axis of the prosthetic liner and locked in the prestretched configuration according to a layer of elastomeric material located along a surface of the textile cover.

Abstract: The present invention relates to a stent using wirelessly transmitted power, and to an external driving device thereof. To this end, a stent is provided with: a power receiving part wirelessly receiving power from the outside; a power storing part storing the power; a second communicating part receiving a control command from the outside; an electrical stimulation part generating electrical stimulation by using the power; a photosensitizer coated onto a stent; an LED illuminating the vicinity of the stent; and a second control part controlling the heat-generating stent on the basis of the control command.

Abstract: Example medical stents are disclosed. An example stent includes a tubular framework including an inner surface, an outer surface and a lumen extending therethrough. Additionally, the stent includes a tissue ingrowth scaffold extending along a portion of the outer surface of the tubular framework, wherein the tissue ingrowth scaffold is spaced radially away from the outer surface of the tubular framework to define an expansion cavity therebetween and wherein the tissue ingrowth scaffold permits tissue ingrowth along a portion thereof. Further, the stent includes an expandable member positioned within at least a portion of the expansion cavity.

Abstract: The present invention relates to a drug-releasing biodegradable stent. The drug-releasing biodegradable stent includes: a first stent structure configured to have a plurality of cells by means of the wire crossing pattern of a woven structure and be provided in a hollow cylindrical shape by weaving a metal wire made of a shape-memory alloy in a specific pattern on a jig; and a second stent structure formed as a 3D print that is provided to have a plurality of cells by means of the wire crossing pattern of a printed structure and also have a hollow cylindrical shape by performing 3D printing using a printing material including a biodegradable polymer and a drug, and disposed such that it covers the outer circumferential surface of the first stent structure or the outer circumferential surface thereof is covered with the first stent structure.

Abstract: Systems and methods for correcting spinal deformity utilize a dynamic, multi-structure torso orthosis that allows motion during wear. The disclosed embodiments utilize a series of elastically coupled ring structures that conform to the circumference of the torso of a patient. Adjustable elastic coupling mechanisms are utilized to create and alter forces and moments that are applied to the torso through these ring structures. In some instances, the ring structures are formed from individual elements that can be linked to accommodate particular anatomies. In other instances, a superior ring structure can be configured to accommodate the patient's upper torso.

Abstract: A garment for restricting the range of motion of a wearer can include a body assembly with one or more garment forming portions configured to form a first side and a second side. The first side and the second side can be removably joined by at least one fastener. The garment further includes first and second sleeves coupled to the body assembly at first and second armpit areas, respectively. Each of the sleeves can be securely attached to the body assembly by first and second attachment devices, respectively. Each of the first attachment device and the second attachment device can extend vertically from the respective armpit area toward a distal end of the respective sleeve. The garment also includes first and second leg portions that can be joined by a third attachment device extending vertically from an inseam toward a distal end of the first and second leg portions.

Abstract: A mouthpiece includes a maxillary piece that is mounted to maxillary dentition, a mandibular piece that is mounted to mandibular dentition, a coupling member that positions the mandibular piece with respect to the maxillary piece, and a spacer. The spacer includes an anchor portion that includes an indentation and that is formed at an inner wall face of the maxillary piece, a protrusion that is fit into the indentation of the anchor portion, and a clamped portion that is clamped between the maxillary piece and the mandibular piece.

Abstract: Packs for providing heat or cold to a body part or parts. In some embodiments, packs comprising an outer flexible shell or skin housing or carrying a plurality of beads mixed in combination with a liquid or gel. In some embodiments, packs, which can be (or are) configured into various shapes, which contain heads in combination with a liquid or gel solution, which can be heated or cooled for application, thereafter, to a body part for providing hot or cold therapy to the body part.

Abstract: A medical cooling pad for cooling skin includes a distal flexible pad support, a flexible cooling gel layer arranged on a proximal side of the distal flexible pad support, and a medical wound dressing arranged on a proximal side of the flexible cooling gel layer. The medical wound dressing has an area which is smaller than an area of the flexible cooling gel layer.

Abstract: A cold compression device has a driving assembly, a tank, a wrap assembly, and a tube assembly. The driving assembly includes a water pump and an air pump. The wrap assembly has a wrap, a water pack in the wrap, and an air pack in the wrap and overlapped on the water pack. The tube assembly has a first tube, a second tube, a third tube, and a fourth tube. The first tube connects the tank and the water pump. The second tube connects the water pump and the water pack. The third tube communicates with the water pack and the tank. The fourth tube connects the air pump and the air pack. Thus, as the first tube is detachable from and put out of the tank, the water pump may draw air into the water pack, which discharges the water in the water pack thoroughly.

Abstract: A system for storing and delivering a predetermined amount of fluid includes a syringe including a barrel, a flange disposed at the proximal end of the barrel, and a plunger assembly configured to be received in the lumen of the barrel. The plunger assembly includes a piston and a plunger rod. The plunger rod is removably couplable to the piston at the distal end of the plunger rod and includes a thumb press flange at the proximal end of the plunger rod. The system further includes a stop feature that is removably couplable to the syringe or the plunger assembly. The stop feature is configured to arrest distal advancement of the plunger assembly relative to the syringe when the plunger assembly reaches a predetermined position relative to the syringe. The stop thus ensures that a predetermined amount of fluid remains in the barrel.

Abstract: Devices and methods to apply eye drops are shown. Example devices include carrier strips with an amount of eye medication included on or within at least one end. In selected methods, a patient touches an end including an amount of medication to their eye, and an amount of the medication is transferred from the carrier to their eye.