Patents Issued in June 20, 2019
  • THICKENED, CLEAR SALT-RICH COMPOSITION, METHOD FOR LIGHTENING SAME, AND USE THEREOF IN COSMETICS
    Publication number: 20190183776
    Abstract: Disclosed is a composition including (per 100% weight): a) 90 wt.-% to 99.0 wt.-% water including, in dissolved form, 0.002 mol/L to 0.1 mol/L of at least one salt of ammonium cation or of a monovalent or multivalent metal cation with an organic or inorganic anion; b) 0.5 wt.-% to 5 wt.-% of a crosslinked anionic polyelectrolyte; and c) 0.5 wt.-% to 5 wt.-% of a compound having formula (II): R1—(O—CH2—CH2)p—OH (II), where the weight ratio of the crosslinked anionic polyelectrolyte to the compound of formula (II) is greater than or equal to 0.2 and less than or equal to 2.0, and the molar ratio of the compound of formula (II) to the salt greater than or equal to 0.05 and less than or equal to 1. Also disclosed is a composition in cosmetics and a method for lightening the thickened salt-rich composition.
    Type: Application
    Filed: July 18, 2017
    Publication date: June 20, 2019
    Inventors: Benoît VERDU, Cindy SOURDON, Alicia ROSO
  • LOW VISCOSITY, COMPACT SHAMPOO COMPOSITION CONTAINING SILICONE POLYMERS
    Publication number: 20190183777
    Abstract: A clear shampoo composition containing a silicone emulsion and a detersive surfactant. The silicone emulsion contains one or more silicone polymers that can be a polyorganosiloxane compound containing one or more quaternary ammonium groups, silicone blocks comprising between about 99 and about 199 siloxane units on average, at least one polyalkylene oxide structural unit; and at least one terminal ester group.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Inventors: Jade Yvonne Gillis, Robert Wayne Glenn, JR., Dariush Hosseinpour, Brian Michael Hurley, Tiffany Tien-Yun Yang, Jean Jianqun Zhao, Michael Albert Snyder, Roland Wagner, Albert Schnering, Katharina Streicher
  • LOW VISCOSITY CONDITIONER COMPOSITION CONTAINING SILICONE POLYMERS
    Publication number: 20190183778
    Abstract: A concentrated conditioner composition to be dispensed as a foam from a foam dispenser, wherein the composition comprises one or more silicone polymers. The silicone polymers is a polyorganosiloxane compound containing one or more quaternary ammonium groups, silicone blocks comprising between about 99 and about 199 siloxane units on average, at least one polyalkylene oxide structural unit; and at least one terminal ester group.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Inventors: Robert Wayne Glenn, JR., Tiffany Tien-Yun Yang, Michael Albert Snyder, Roland Wagner, Albert Schnering, Katharina Streicher
  • NAIL COATING SYSTEM
    Publication number: 20190183779
    Abstract: The present technology provides a nail coating system suitable for improving the nail plate to which it is applied. The nail coating system includes two components—an oil-based serum and a base composition. In use, the oil-based serum may be applied directly to a nail plate without first cleaning the nail plate with alcohol and/or acetone. The oil-based serum coat may fill in any cracks and crevices in the nail plate and restoring sebum and water on the nail plate. After the oil-based serum layer is buffed into the nail, the base composition may be applied for the oil-based serum coat. After the base composition dries, a user may apply a top coat, a tinted nail polish, a perfector product, etc. The resulting nail plate has improved features and restored natural sebum and water levels in the nail plate.
    Type: Application
    Filed: July 21, 2017
    Publication date: June 20, 2019
    Inventor: Rebecca ISA
  • Taurine and Aloe Synergistic Anti-Irritant Compositions and Methods
    Publication number: 20190183780
    Abstract: Personal care compositions containing active ingredients and an anti-irritant combination of aloe and taurine are disclosed. Methods of preparing the personal care composition and uses of the personal care composition are also disclosed.
    Type: Application
    Filed: May 10, 2016
    Publication date: June 20, 2019
    Applicant: Colgate-Palmolive Company
    Inventors: Long PAN, Jung SEO, Zeenat NABI, Shujiang CHENG, Nadia SOLIMAN, Laurence D. DU-THUMM, Diana SCALA, Kyle ROBBINS, Rahul PATEL, Marian HOLERCA
  • SKIN CARE FORMULATION
    Publication number: 20190183781
    Abstract: There is provided a skin care formulation for transdermal administration of a component of a blood product, the formulation comprising a blood product, a transdermal carrier; and a liposomal base, wherein at least a portion of the blood product and transdermal carrier is contained within liposomes of the liposomal base.
    Type: Application
    Filed: June 2, 2017
    Publication date: June 20, 2019
    Applicant: EMBRYOGENESIS PTY LTD
    Inventors: Peter Britton, Andrew French
  • PROBIOTIC INFUSED DENTAL FLOSS
    Publication number: 20190183782
    Abstract: A disclosure is provided for a method of probiotic microorganism infusion of an interdental hygienic device whereby the microorganisms may be released upon device usage (dental flossing) conferring an additional benefit to interdental hygienic devices.
    Type: Application
    Filed: December 18, 2017
    Publication date: June 20, 2019
    Inventor: David Lyman Nelson
  • SKIN CARE COMPOSITION
    Publication number: 20190183783
    Abstract: Disclosed is a skin care composition with a carrier substance and a proportion of lactic acid bacteria or their metabolic products.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 20, 2019
    Inventors: Ursula Fritzmeier, Birgit Lewandowski
  • METHOD OF PREPARING A PHARMACEUTICAL COMPOSITION
    Publication number: 20190183784
    Abstract: The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: STEPHEN W. STEIN, DAVID W. SCHULTZ, JOHN K. SIMONS, WILLIAM F. HANSEN
  • NANOPARTICLE COMPOSITIONS, FORMULATIONS THEREOF, AND USES THEREFOR
    Publication number: 20190183785
    Abstract: The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions. Methods generally involve administering nanoparticle compositions (e.g., nanoparticle compositions comprising at least one known therapeutic agent and/or independently active biologically active agent; and/or empty nanoparticle compositions) to a subject in need thereof.
    Type: Application
    Filed: October 18, 2018
    Publication date: June 20, 2019
    Inventors: Jonathan Edelson, Timothy Kotyla, Klaus Theobald
  • COMPOSITIONS FOR SENSITIVE SKIN
    Publication number: 20190183786
    Abstract: Disclosed are compositions and methods for their use that include a combination of hydrolyzed algin, escin, Ruscus aculeatus root extract, ammonium glycyrrhizate, Centella asiatica extract, hydrolyzed yeast protein, and Calendula officinalis flower extract.
    Type: Application
    Filed: December 27, 2018
    Publication date: June 20, 2019
    Inventors: David GAN, Tiffany CARLE, Michelle HINES, Milagros SANCHEZ, Patricia JACOBY, Linda HART
  • TOPICAL THERAPY FOR THE TREATMENT OF SKIN MALIGNANCIES USING NANOPARTICLES OF TAXANES
    Publication number: 20190183787
    Abstract: Disclosed are methods useful for the topical therapeutic treatment of skin malignancies including skin cancers and cutaneous metastases using compositions containing nanoparticles of paclitaxel or other taxanes.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 20, 2019
    Applicant: DFB SORIA, LLC
    Inventor: Gere DIZEREGA
  • ANTI-CD37 IMMUNOCONJUGATE AND ANTI-CD20 ANTIBODY COMBINATIONS
    Publication number: 20190183788
    Abstract: Methods of administering immunoconjugates that bind to CD37 (e.g., IMGN529) in combination with antibodies that bind to CD20 are provided. The methods comprise administering an anti-CD37 immunoconjugate (e.g., IMGN529) and an anti-CD20 antibody to a person in need thereof, for example, a cancer patient.
    Type: Application
    Filed: October 25, 2018
    Publication date: June 20, 2019
    Inventors: Angela Romanelli, Rodrigo R. Ruiz-Soto, Jose Ponte, Jutta Deckert, Jan Pinkas
  • INTRAVASCULAR DELIVERY OF NANOPARTICLE COMPOSITIONS AND USES THEREOF
    Publication number: 20190183789
    Abstract: The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Kirk SEWARD, Neil P. DESAI
  • SINGLE DOSE NON-ADJUVANTED CUTANEOUS TETANUS VACCINE AND USES THEREOF
    Publication number: 20190183790
    Abstract: A method for preventing or treating tetanus infection in a subject, comprising administering a non-adjuvanted tetanus toxoid vaccine to the skin. The vaccine can be delivered by intradermal injection or microneedle patch and does not require cold storage.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Ioanna Skountzou, E. Stein Esser, Richard Compans, Shaguna Seth
  • SHORT DURATION DEPOT FORMULATIONS
    Publication number: 20190183791
    Abstract: Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.
    Type: Application
    Filed: December 28, 2018
    Publication date: June 20, 2019
    Inventors: Guohua Chen, David T. Priebe
  • COMPOSITION AND METHOD FOR TREATING HERPESVIRUS IN MAMMALS
    Publication number: 20190183792
    Abstract: Disclosed is a composition and method for ocular infection, including treating ocular herpesvirus infection, including feline herpesvirus (FHV), canine herpesvirus (CHV), and equine herpesvirus (EHV), where the composition includes povidone-iodine and DMSO.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 20, 2019
    Inventors: Joseph CAPRIOTTI, Kara CAPRIOTTI, Jesse PELLETIER, Kevin STEWART
  • COLCHICINE DRUG-TO-DRUG INTERACTIONS
    Publication number: 20190183793
    Abstract: The use of oral colchicine solutions in combination with other therapeutics, while minimizing toxic drug to drug interactions are described herein. Related compositions are also provided.
    Type: Application
    Filed: October 9, 2018
    Publication date: June 20, 2019
    Applicant: RxOMEG Therapeutics LLC
    Inventors: Indu Muni, Naomi Vishnupad
  • COLCHICINE DRUG-TO-DRUG INTERACTIONS
    Publication number: 20190183794
    Abstract: The use of oral colchicine solutions in combination with other therapeutics, while minimizing toxic drug to drug interactions are described herein. Related compositions are also provided.
    Type: Application
    Filed: October 9, 2018
    Publication date: June 20, 2019
    Applicant: RxOMEG Therapeutics LLC
    Inventors: Indu Muni, Naomi Vishnupad
  • Solid Solution Compositions and Use in Chronic Inflammation
    Publication number: 20190183795
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Applicant: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • COMBINATION TAXOID NANOEMULSION WITH IMMUNOTHERAPY IN CANCER
    Publication number: 20190183796
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicants: TargaGenix, Inc., The Research Foundation for The State University of New York, Northeastern University
    Inventors: James E. Egan, Mansoor Amiji, Iwao Ojima
  • BETULIN-CONTAINING WATER-IN-OIL FOAMS AND COMPOSITIONS THEREOF
    Publication number: 20190183797
    Abstract: The present disclosure relates to foams comprising outer birch bard extracts. Stable compositions thereof, as well as methods of producing such foams, and methods of using of such foams are also described herein. The foams of the present disclosure contain triterpenes, which are known to improve wound healing.
    Type: Application
    Filed: July 18, 2017
    Publication date: June 20, 2019
    Inventors: Rolf Daniels, Tobias Zahn
  • METHOD FOR TREATING TUMOR
    Publication number: 20190183798
    Abstract: A method of treating a subject having or suspected of having a solid tumor, comprises administering to the subject an effective amount of a liposome-encapsulated drug, and applying an amplitude-modulated (AM) radiofrequency radiation to the solid tumor.
    Type: Application
    Filed: June 17, 2016
    Publication date: June 20, 2019
    Applicant: Johnpro Biotech Inc.
    Inventors: Kwan-Hwa CHI, Yu-Shan WANG, Hsin-Chien CHIANG, Cheng-Chung HUANG
  • AMPHIPHILIC MOLECULES LAYERS
    Publication number: 20190183799
    Abstract: The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
    Type: Application
    Filed: October 13, 2016
    Publication date: June 20, 2019
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNR S, Université d'Aix-Marseille
    Inventors: Ahmad Kenaan, Anne Magali Charrier, Sébastien Lavandier, Jean-Manuel Raimundo
  • TRANSMEMBRANE PH-GRADIENT POLYMERSOMES AND THEIR USE IN THE SCAVENGING OF AMMONIA AND ITS METHYLATED ANALOGS
    Publication number: 20190183800
    Abstract: The present invention provides polymersomes comprising non-biodegradable amphiphilic block-copolymers and their enteral (e.g., oral) or topical use in the treatment of an ammonia or ammonia methylated analog-associated disease or disorder or symptom thereof (e.g., hyperammonemia or trimethylaminuria). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid. It also provides a method of making the polymersome comprising mixing the copolymer-containing organic solvent phase with an aqueous phase containing the acid.
    Type: Application
    Filed: August 15, 2017
    Publication date: June 20, 2019
    Applicant: ETH Zurich
    Inventors: Jean-Christophe Leroux, Simon Matoori, Aaron Christoph Schmidt
  • METHOD FOR THE PRODUCTION OF A DOSAGE FORM
    Publication number: 20190183801
    Abstract: A method is described for producing a dosage form and granules including surface-reacted calcium carbonate. Also described, are tablets and/or capsules obtained by the method. Methods using such a surface-reacted calcium carbonate, and a dosage form comprising the granules are also described. Further, methods of using the granules, or the tablets and/or capsules, or the dosage form in a pharmaceutical product, a nutraceutical product, an agricultural product, a cosmetic product, a home product, a food product, a packaging product and a personal care product are also described. A pharmaceutical product, a nutraceutical product, an agricultural product, a cosmetic product, a home product, a food product, a packaging product and a personal care product including the granules, or the tablets and/or capsules, or the dosage form are also described.
    Type: Application
    Filed: June 14, 2017
    Publication date: June 20, 2019
    Inventors: Carolina DIAZ QUIJANO, Laura DE MIGUEL, Joachim SCHÖLKOPF
  • ACTIVE SELF-HEALING BIOMATERIAL SYSTEM
    Publication number: 20190183802
    Abstract: Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affmity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Steven P. Schwendeman, Kashappa-Goud Desai
  • FREEZE-DRIED FORMULATIONS OF ANTIBACTERIAL PROTEIN
    Publication number: 20190183803
    Abstract: A freeze-dried formulation includes an antibacterial protein having killing activity specific to at least one of or all following species: Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus carnosus, Staphylococcus carprae, Staphylococcus chromogenes, Staphylococcus cohnii, Staphylococcus delphini, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus gallinarum, Staphylococcus hemolyticus, Staphylococcus hominis, Staphylococcus intermedius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus muscae, Staphylococcus pasteuri, Staphylococcus saprophyticus, Staphylococcus warneri, and Staphylococcus xylosus; a poloxamer; a sugar, and an amino acid.
    Type: Application
    Filed: January 9, 2017
    Publication date: June 20, 2019
    Applicant: INTRON BIOTECHNOLOGY, INC.
    Inventors: Seong Jun YOON, Soo Youn JUN, Gi Mo JUNG, Sang Hyeon KANG
  • SOLID DRUG STORAGE APPARATUS, FORMULATIONS AND METHODS OF USE
    Publication number: 20190183804
    Abstract: Embodiments of the invention provide drug packaging and methods for producing drug packaging which can be sealed at room temperature and/or without the need for elevated temperatures above room temperature. Many embodiments provide drug packaging comprising pierceable tubing having a capsule shape (also referred to herein as a pierceable capsule and/or pierceable drug capsule) containing a solid drug such as a drug pellet and methods for producing pierceable drug capsules which can be sealed at room temperature. Embodiments are particularly useful for the packaging and delivery of drugs used in implantable drug delivery devices as well as packaging of drugs that are easily thermally degraded.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Inventors: Elmar Fischer, Paul Spehr
  • PHARMACEUTICAL COMPOSITION COMPRISING POMALIDOMIDE
    Publication number: 20190183805
    Abstract: The present invention relates to a pharmaceutical composition comprising pomalidomide, maltodextrin and a filler, wherein the weight ratio of maltodextrin to filler ranges from 1:1 to 1:2. The invention further relates to the use of said pharmaceutical composition as medicament in the treatment of multiple myeloma.
    Type: Application
    Filed: July 28, 2017
    Publication date: June 20, 2019
    Applicant: Synthon BV
    Inventors: Sonia GARCIA JIMENEZ, Luis NOGUEIRAS NIETO, Lisardo ALVAREZ FERNANDEZ, Jose VELADA CALZADA
  • PACKAGED MODIFIED RELEASE GAMMA-HYDROXYBUTYRATE FORMULATIONS HAVING IMPROVED STABILITY
    Publication number: 20190183806
    Abstract: Packaged formulations of gamma-hydroxybutyrate having improved dissolution and chemical stability, packaging for supporting said stability, and therapeutic uses thereof.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Inventor: Hervé Guillard
  • Therapeutic Agent Release System
    Publication number: 20190183807
    Abstract: A therapeutic agent release system may be provided. The therapeutic agent release system may include a plurality of polymer shells having a diameter of about 50-200 nanometers. The therapeutic agent release system may further include a bio-active therapeutic agent encapsulated by each of the polymer shells and being configured to heal an injury and increase a wound electric signal of the injury thereby increasing a healing rate of the injury. Each of the polymer shells may have a degradation profile configured to control a release of the bio-active therapeutic agent through the polymer shell to the injury over a predetermined period of time.
    Type: Application
    Filed: October 19, 2018
    Publication date: June 20, 2019
    Inventors: Lance M. Baird, Xiomara Calderon-Colon, Morgana M. Trexler, Leslie H. Hamilton
  • Methods and Compositions Particularly for Treatment of Attention Deficit Disorder
    Publication number: 20190183808
    Abstract: There is described, inter alia, a coated bead comprising: (a) a granule; (b) a first layer coated over the granule, the first layer comprising a first amount of an active pharmaceutical ingredient comprising a central nervous system stimulant; and (c) a second layer coated over the first layer, the second layer being present in an amount sufficient to substantially delay release of the active pharmaceutical ingredient in the first layer until after the coated bead reaches a distal intestine portion of a subject to whom the coated bead is administered; and (d) the third layer coated over the second layer, the third layer comprising a second amount of the active pharmaceutical ingredient, the third layer being configured to permit substantially immediate release of the active pharmaceutical ingredient comprised therein. Embodiments related to a solid oral pharmaceutical composition are also described.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Ricardo Alberto VARGAS RINCON, Joseph REIZ
  • Methods and Compositions Particularly for Treatment of Attention Deficit Disorder
    Publication number: 20190183809
    Abstract: There is described, inter alia, a coated bead comprising: (a) a granule; (b) a first layer coated over the granule, the first layer comprising a first amount of an active pharmaceutical ingredient comprising a central nervous system stimulant; and (c) a second layer coated over the first layer, the second layer being present in an amount sufficient to substantially delay release of the active pharmaceutical ingredient in the first layer until after the coated bead reaches a distal intestine portion of a subject to whom the coated bead is administered; and (d) the third layer coated over the second layer, the third layer comprising a second amount of the active pharmaceutical ingredient, the third layer being configured to permit substantially immediate release of the active pharmaceutical ingredient comprised therein. Embodiments related to a solid oral pharmaceutical composition are also described.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Ricardo Alberto VARGAS RINCON, Joseph REIZ
  • TRANSDERMAL ADHESIVE COMPOSITION COMPRISING A VOLATILE LIQUID THERAPEUTIC AGENT HAVING LOW MELTING POINT
    Publication number: 20190183810
    Abstract: Methods, compositions, and devices for transdermally administering an active agent such as memantine are provided.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Inventors: Eun Soo Lee, Parminder Singh, Appala Sagi, Amit K. Jain
  • COMPOSITION CONTAINING SQUALENE FOR IMPROVING MUSCLE FUNCTION AND PREVENTING MUSCLE DAMAGE
    Publication number: 20190183811
    Abstract: The present invention relates to a composition for preventing, treating, or ameliorating muscle disease or regenerating damaged muscles, comprising squalene. More specifically, the squalene of the present invention increases expression of proteins which are associated with muscle protein synthesis and muscle mass increase in muscle cells, inhibits, at an mRNA level, expression of enzymes involved in muscle protein degradation, and has an effect of rapidly restoring damaged muscles. In addition, the present invention relating to a natural product can be safely used without side effects, and thus can be used as medicines, foods, or cosmetics.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 20, 2019
    Applicant: AAT COSTECH CO., LTD.
    Inventors: Jae Kwan HWANG, Se In LEE, Mi Bo KIM, Chang Hee KIM
  • Compounds For The Treatment Of Neuromuscular Disorders
    Publication number: 20190183812
    Abstract: The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.
    Type: Application
    Filed: December 14, 2018
    Publication date: June 20, 2019
    Applicant: NMD PHARMA A/S
    Inventors: Lars J.S. Knutsen, Nicholas M. Kelly, Thomas Holm Pedersen, Claus Elsborg Olesen, Marc Labelle, Paul Brian Little, Martin E. Cooper, Neerja Saraswat, Dastagiri Dudekula, Rafiq A. Taj
  • THERAPEUTIC COMPOSITIONS FOR TREATING PANCREATIC CANCER
    Publication number: 20190183813
    Abstract: The present invention is directed to therapeutic compositions for treating pancreatic cancer comprising a cyclohexnone compound and one or more anti-cancer agents.
    Type: Application
    Filed: October 11, 2018
    Publication date: June 20, 2019
    Inventors: Sheng-Yung Liu, Chih-Ming Chen
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING SKIN CONDITIONS
    Publication number: 20190183814
    Abstract: This disclosure relates to new compositions and methods for treating skin conditions as a result of sun damage. In one embodiment this disclosure pertains to new compositions for treating or preventing sunburns, skin damage, and/or harm from radiation, such as UV radiation.
    Type: Application
    Filed: August 10, 2017
    Publication date: June 20, 2019
    Inventor: Marshall Ollie ALMARODE
  • TIME RELEASE OF CoQ10
    Publication number: 20190183815
    Abstract: Compositions are provided that provide an extended release of CoQ10. In certain aspects, the extended release CoQ10 composition includes an extended release bead multiparticulate comprising CoQ10 configured to release the CoQ10 over a period of 4 hours or more. In other aspects, the extended release CoQ10 composition includes an extended release lipid multiparticulate comprising CoQ10 configured to release the CoQ10 over a period of 4 hours or more.
    Type: Application
    Filed: August 14, 2017
    Publication date: June 20, 2019
    Inventors: Tyler O. White, Matthew Hesse
  • ALKOXY COMPOUNDS FOR DISEASE TREATMENT
    Publication number: 20190183816
    Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
    Type: Application
    Filed: July 23, 2018
    Publication date: June 20, 2019
    Inventors: Ian L. SCOTT, Vladimir A. KUKSA, Mark W. ORME, Thomas L. LITTLE, JR., Anna GALL, Feng HONG
  • EXTENDED RELEASE SUSPENSIONS OF MIXTURES OF DEXTRO- AND LEVO-AMPHETAMINES
    Publication number: 20190183817
    Abstract: The present invention relates to the pharmaceutical compositions of a mixture of dextro- and levo-amphetamines complexed with ion exchange resin and precursor resins. More particularly the invention relates to Attention Deficit Hyperactivity Disorder (ADHD) effective agent dosage forms that both facilitate oral ingestion and provide an effective treatment over a prolonged period oftime. In particular, the invention provides for pharmaceutical compositions having a first and second plurality of particles, where the first plurality of particles comprises drug-resin particles and the second plurality of particles comprises drug-precursor resin particles with or without any extended release coating, where the drug is an ADHD effective agent and the composition achieves an escalating in vivo plasma concentration of the ADHD effective agents selected from amphetamine and methylphenidate.
    Type: Application
    Filed: December 10, 2018
    Publication date: June 20, 2019
    Inventors: Bharat Kirthivasan, Sabarinath Shankar, James Garegnani, Arjun Muthukkaruppan
  • Inhibition of Sphingosine 1-Phosphate Receptor for Treatment and Prevention of Lymphedema
    Publication number: 20190183818
    Abstract: Provided are methods of and compositions for treating or preventing lymphedema by administering a sphingosine 1-phoshate receptor modulator.
    Type: Application
    Filed: August 17, 2017
    Publication date: June 20, 2019
    Inventor: Babak Mehrara
  • METHODS AND SYSTEMS FOR TREATING VITILIGO USING PHLOROGLUCINOL AND RELATED COMPOSITIONS
    Publication number: 20190183819
    Abstract: The present invention generally relates to systems and methods for treating vitiligo and related conditions. In some embodiments, a composition comprising phloroglucinol and/or related compounds, such as benzenetriols, phlorotannins, or algae extract, is applied to the skin. The composition may be formulated for application to the skin of a subject, for instance, as a gel, lotion, cream, ointment, soap, or stick. The composition may also comprise a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present as a liquid crystal, and/or in liposomes, micelles, or other vesicles. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 20, 2019
    Applicant: Transdermal Biotechnology, Inc.
    Inventors: Nicholas V. Perricone, Peter T. Pugliese
  • NON-RACEMIC BETA-HYDROXYBUTYRATE COMPOUNDS AND COMPOSITIONS ENRICHED WITH THE S-ENANTIOMER AND METHODS OF USE
    Publication number: 20190183820
    Abstract: Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the S-enantiomer are formulated to control ketone body levels in a subject. The non-racemic mixture of BHB is enriched with the S-enantiomer to modulate the effect of ketone bodies in the subject and control the rate at which ketosis is achieved. In some aspects a composition for controlling ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate, wherein the non-racemic mixture contains from about 52% to 99% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer and from about 48% to about 1% by enantiomeric equivalents of R-beta-hydroxybutyrate enantiomer.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Inventor: Gary Millet
  • NON-RACEMIC BETA-HYDROXYBUTYRATE COMPOUNDS AND COMPOSITIONS ENRICHED WITH THE S-ENANTIOMER AND METHODS OF USE
    Publication number: 20190183821
    Abstract: Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the S-enantiomer are formulated to control ketone body levels in a subject. The non-racemic mixture of BHB is enriched with the S-enantiomer to modulate the effect of ketone bodies in the subject and control the rate at which ketosis is achieved. In some aspects a composition for controlling ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate, wherein the non-racemic mixture contains from about 52% to 99% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer and from about 48% to about 1% by enantiomeric equivalents of R-beta-hydroxybutyrate enantiomer.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 20, 2019
    Inventor: Gary Millet
  • Compositions and Methods of Use of Beta-Hydroxy-Beta-Methylbutyrate (HMB) FOR MODULATING AUTOPHAGY AND LIPOPHAGY
    Publication number: 20190183822
    Abstract: The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to modulate autophagy and lipophagy. HMB is also administered to treat, prevent, inhibit, slow or reduce autophagy-mediated conditions or diseases.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 20, 2019
    Inventors: Naji Abumrad, John Rathmacher, Shawn Baier
  • STABLE IBUPROFEN INJECTABLE COMPOSITION
    Publication number: 20190183823
    Abstract: The present invention relates to a composition for injectable formulation, the composition comprising:- An aqueous solution of ibuprofen and arginine with a molar ratio of ibuprofen:arginine comprised between 1:1.1 and 1:2.1;- An aqueous solution of a diuretic compound comprising between 3.9% and 4.35% w/v of the diuretic compound. The present invention also concerns a pharmaceutical composition comprising said composition and the use of said composition and said pharmaceutical composition.
    Type: Application
    Filed: July 27, 2017
    Publication date: June 20, 2019
    Inventor: Irfan Jamil
  • USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS
    Publication number: 20190183824
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 20, 2019
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • RECEPTOR SUBTYPE AND FUNCTION SELECTIVE RETINOID AND REXINOID COMPOUNDS IN COMBINATION WITH IMMUNE MODULATORS FOR CANCER IMMUNOTHERAPY
    Publication number: 20190183825
    Abstract: Disclosed herein are methods for culturing CAR-modified immune cells with at least one Retinoic Acid Receptor and/or Retinoid X Receptor active agent.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 20, 2019
    Inventors: Roshantha A. Chandraratna, Martin E. Sanders