Abstract: Apparatus for blood processing comprising a blood collection reservoir (30), a blood collection conduit, a blood transfer conduit, and a manually operable pump unit (10) comprising first and second peristaltic pumps (10A, 10B). The first peristaltic pump is mounted about and acts upon the blood collection conduit. The second peristaltic pump is mounted about and acts upon the blood transfer conduit. The pump unit is provided with an actuator (112) adapted to switch the second peristaltic pump between an operative condition and an inoperative condition: in the operative condition the second peristaltic pump is engaged with the blood transfer conduit to convey blood from the blood collection reservoir while the first peristaltic pump is engaged with the blood collection conduit to convey blood from a wound site to the blood collection reservoir, and in the inoperative condition the second peristaltic pump is disengaged from the blood transfer conduit.

Abstract: The present invention provides a skin attachment device for use with implantable medical devices which extend through the skin for prolonged durations.

Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.

Abstract: A rotary machine is provided which may include a rotor and a stator within a housing. The stator may be for generating a rotating magnetic field for applying a torque to the rotor. A commutator circuit may provide a plurality of phase voltages to the stator, and a controller may adjust the plurality of phase voltages provided by the commutator circuit to modify an attractive force of the stator on the rotor to move the rotor in an axial direction.

Abstract: In a catheter (2) to assist the performance of a heart (1) with at least one pump (7), the pump is formed as a rotary pump at the distal end of the catheter (2), the rotor (6) lying distally on the outer side being coupled via a magneto coupling with a drive wheel (21), formed as a hydraulically or pneumatically operated paddle wheel, arranged inside the catheter (2). The driving fluid is supplied to the paddle wheel via a lumen (22) of the catheter (2) and is carried off via a further lumen (23) of the catheter.

Abstract: Disclosed herein is a fully implantable artificial heart. The use of flat helical springs to align and reciprocate a bellows structure allows the bellows to pump blood, the multiple solenoids with floating magnetized rods and permanent magnet assemblies held by the flat helical springs provide the power. The artificial heart pumps blood with virtually no friction and no parts to wear out. The use of solenoids advantageously move blood in a gentle, controllable manner.

Abstract: A method of determining a heart rate of a patient having an implanted blood pump including applying a voltage to a plurality of coils of a stator of the blood pump to produce an electromagnetic force to rotate a rotor in communication with the plurality of coils; displaying a waveform associated with a back electromotive force in the plurality of coils of the blood pump, the waveform being proportional to an axial position of the rotor relative to the stator; determining a time interval between a first alteration in the waveform relative to a baseline and a second alteration in the waveform relative to the baseline; and determining the heart rate of the patient based on the time interval.

Abstract: Apparatus and methods are described for use with a tributary vessel of a subject that supplies a vein of the subject. Blood within the tributary vessel is mechanically isolated into a compartment that is separated from blood within the vein. Blood flow from the tributary vessel to the vein is controlled by pumping blood from the compartment to the vein. Other applications are also described.

Abstract: A dialyzer and a fabricating method thereof are provided. The dialyzer includes a housing, a hydrophilic layer, a fixing layer, a plurality of hollow fiber membranes, and two end caps. The housing has a first opening and a second opening, and is provided with a dialysate inlet and a dialysate outlet, wherein an entire peripheral surface of the housing located between the first opening and the dialysate inlet is a first portion, and an entire peripheral surface of the housing located between the second opening and the dialysate outlet is a second portion. The hydrophilic layer is disposed on the inner wall of the first portion and the second portion, wherein the hydrophilic layer and the housing are different materials. The fixing layer is disposed on the hydrophilic layer and fixes the hollow fiber membranes to the inner wall of the housing.

Abstract: An end cap of a dialyzer and a fabricating method thereof, and a dialyzer are provided. The end cap includes a main body and a sealing element. The main body has a blood port. The sealing element is integrally connected on an inner wall of the main body.

Abstract: This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.

Abstract: A method for prophylaxis or treatment of a graft's rejection of a recipient, driven and adjusted by a microprocessor-based controller. Provided is a fluid circuit comprising a first container configured to receive a transplant component and a second container configured to receive an apoptotic component. Provided is a separator configured to associate with the fluid circuit and separate whole blood into a red blood cell component, a plasma component, and a white blood cell component. Whole blood is directed into the fluid circuit and the separator. The whole blood is separated into the red blood cell component, the plasma component, and the white blood cell component. A first portion comprising the transplant component of the white blood cell component is directed to the first container. A second portion of the white blood cell component is directed to the second container and the second portion is rendered apoptotic.

Abstract: An apparatus for nasal irrigation comprising a resiliently compressible bottle component and a spout having a proximal end for demountable engagement with the bottle component. The distal end of the spout may be molded for sealable engagement with a user's nostril. Alternatively, the distal end of the spout may be threaded for demountable sealable engagement with a nasal tip molded for sealable engagement with a user's nostril. The tip may be configured for delivering a solution in the form of a stream, or a spray, or a misting. A kit comprising the nasal irrigation apparatus and one or more selected volumes of one or more nasal irrigation solutions. The kit may additionally comprise one or more nasal tips. The nasal irrigation solution may comprise one or more of an antibiotic, an antihistamine, a steroid, a vasoconstrictor, an emollient, and an ion.

Abstract: An insulated, soft, durable fabric pouch sized and adapted to hold one or more epinephrine auto-injectors, or insulin injectors, the pouch including preferably a gel type insulation surrounding at least a major part of the injector(s), a rapid-opening top flap to facilitate immediate and easy availability of the injector for grasping and using by the user.

Abstract: A syringe package contains a prefilled syringe system including a prefilled syringe that includes a syringe body that is filled with a drug, a gasket located in the syringe body, and a plunger partially disposed in the syringe body. The syringe package includes: a package body that houses the prefilled syringe; and a support that is disposed inside the package body and that supports the prefilled syringe. The support includes a displacement regulation unit configured to regulate relative displacement of the syringe body and the plunger in a direction in which the gasket and the plunger approach each other.

Abstract: Diabetes management systems may include a glucose monitoring device adapted to transmit glucose data and at least one accessory in communication with the glucose monitoring device and adapted to provide at least one alarm or alert based on the glucose data.

Abstract: One or more embodiments of the disclosure relate, generally, to a pen cap for a manual insulin delivery device. Such a pen cap may include a wireless communication interface, a detection circuit, a user interface, and a processor and memory. The detection circuit may be configured to detect cappings and decappings of the pen cap from a manual insulin delivery device. Timing information and recommendations related to capping and decapping of the pen cap may be presented to a user.

Abstract: One or more embodiments relate, generally, to a reusable accessory for a medication injection pen. Such a reusable accessory may be adapted to be reversibly attached to a medication injection pen, and configured to detect an event associated with an injection of medication from the medication injection pen. It may also be configured to determine a percentage of medication that remains active for injection by the medication injection pen based on timing information and dosing event information.

Abstract: One or more embodiments of the disclosure relate, generally, to a therapy management system including signaling outputs to present alarms, alerts, and/or notifications discernable by a user. A glucose sensor system may wirelessly transmit blood glucose data to a reusable accessory adapted to be reversibly connectable to an insulin injection pen or other insulin delivery device. A mobile device may control the signaling outputs to present the alarms, alerts, and/or notifications based, at least in part, the blood glucose data.

Abstract: The present invention discloses a path-type liquid medicine delivery electro-osmosis pump that can be applied to a wearable medicine device. An electro osmosis pump according to the present invention includes: a connector provided with a liquid medicine inlet and a liquid medicine outlet; a check valve assembly combined to one side of the connector; and a driver that is connected to the other side of the connector and moves the liquid medicine toward the liquid medicine outlet by applying pressure to the liquid medicine while being separated from the liquid medicine, which passes through the check valve assembly.

Abstract: An infusion pouch set with a built-in injection medicine bottle having a vial function including: a discharge port 20 provided at an outlet 12 of a pouch container 10; and an injection port 30 provided at an inlet 14 of the pouch container 10; wherein the injection port 30 comprises, an injection needle part 40 configured to have an injection needle 44 provided vertically on an upper part of an injection needle holder 42 which is welded to the inlet 14 of the pouch container 10; an inner cap 50 having a sealing membrane 52 which is coupled to the injection needle holder 42 of the injection needle part 40, accommodates the injection needle 44 therein, and is punctured by the injection needle 44 when lowered; an outer cap 60 which is vertically moveable along the same axis as the inner cap 50 and accommodates an injection medicine bottle 70 in an upside down state therein; and a packing holder 90 which is vertically movably coupled at an upper part of the sealing membrane 52 of the inner cap 50, and a lower par

Abstract: An intraosseous needle assembly includes a needle having a first cylindrical shaft. The shaft having a distal end, a proximal end, and a wall defining an inner channel. The first cylindrical shaft includes threading protruding from the wall along a proximal portion of the first cylindrical shaft. The needle further includes a needle head extending from the proximal end of the first cylindrical shaft. The needle assembly may further include a stylet, the stylet having a second cylindrical shaft having a first end and a second end and a stylet head extending from the second end. The stylet head includes a proximal surface and a distal surface, a pair substantially parallel second side walls, a pair of rounded end sections joining the second side walls, a protrusion extending from the distal surface, and a tapered section extending from the distal surface to the second cylindrical shaft.

Abstract: The invention concerns a device (1) for measuring a fill level of a flexible medicine reservoir (6). The device (1) comprises a support (2) for supporting the flexible medicine reservoir (6) and a leaf spring member (3). A first section (31) of the leaf spring member (3) is mounted to a fixed bearing. A second section (32) of the leaf spring member (3) is guided by a floating bearing. The leaf spring member (3) is designed for contacting the flexible medicine reservoir (6) and for providing that changes in the fill level of the flexible medicine reservoir (6) effect changes of the form of the leaf spring member (3). A detector (5) is arranged for detecting the effected changes of the form of the leaf spring member (3) and for enabling measuring of the fill level of the flexible medicine reservoir (6).

Abstract: Disclosed is a flow detector (1) for releasable coupling with a flow channel (20) in a channel coupling area and detecting a flow of liquid drug in the flow channel (20), the flow detector including: an upstream thermoelectric element (10a) and a downstream thermoelectric element (10b), wherein the upstream thermoelectric element (10a) and the downstream thermoelectric element (10b) are arranged spaced apart from each other and movable independent from each other; an upstream biasing element (15a) and a downstream biasing element (15b), wherein the upstream biasing elements (15a) acts on the upstream thermoelectric element (10a), thereby biasing the upstream thermoelectric element (10a) towards the channel coupling area, and the downstream biasing element (15b) acts on the downstream thermoelectric element (10b), thereby biasing the downstream thermoelectric element (10b) towards the channel coupling area independently from the upstream biasing element (15a).

Abstract: A method of performing an intravenous drip injection includes a first step, a second step, a third step and a fourth step. A first step includes starting dosing an infusion solution containing a predetermined component by the intravenous drip injection to a dosing recipient. A second step includes extracting a body fluid from the dosing recipient being dosed with the infusion solution. A third step includes measuring a concentration of the predetermined component in the extracted body fluid. A fourth step includes varying the concentration of the predetermined component in the infusion solution, corresponding to the concentration of the predetermined component in the body fluid.

Abstract: An injection device comprising: a housing arranged to contain a syringe with a piston for sealing the syringe and displacing the medicament, the housing having a proximal end and a distal end, wherein the distal end is intended to be applied against an injection site; a driving mechanism arranged between the piston and the proximal end of the housing; and a locking mechanism comprising a plate member arranged between the driving mechanism and the piston to retain the driving mechanism to retain the driving mechanism in an initial inactive state in which the driving mechanism cannot be actuated; wherein when the locking mechanism is released, the driving mechanism can be actuated to push the piston towards the distal end of the housing to displace the medicament.

Abstract: An administration apparatus includes an apparatus body, a syringe portion, a piston portion, an ignition device and a sealing member formed of a metal plate-like member. The sealing member separates a space in the apparatus body into a first space where the ignition device is disposed and a second space where the piston portion is disposed, and seals a combustion product generated by the ignition device in the first space. A peripheral edge portion of the sealing member is fixed to an inner wall that defines the space. The sealing member is deformed by the gunpowder combustion such that its central portion is displaced to a side of the piston portion, to thereby press the piston portion against the plunger using the central portion. With this, the generated combustion product is prevented to be administered, and energy for administration is suitably transmitted to the substance to be administered.

Abstract: The present disclosure relates to devices and methods for neutralizing an acidic anesthesia solution. An anesthesia neutralization device includes an outer housing and an inner housing. The inner housing holds a buffer carpule and an anesthetic carpule in a side by side arrangement, with the buffer solution maintained under pressure prior to deployment. A curved transfer needle is coupled to the outer housing and includes ends that both point respectively toward the buffer carpule and anesthetic carpule. The device is actuated by moving the inner housing relative to the outer housing to bring the anesthesia carpule and buffer carpule into contact with the transfer needle and to force buffer solution through the transfer needle and into the anesthesia carpule.

Abstract: The present invention relates in one aspect to a housing for an injection device, comprising: —a body (30) to accommodate a drive mechanism (5) to operably engage with a piston (52) of a cartridge (50) filled with a liquid injectable medicament (53), —a cartridge holder (20) having a cartridge receiving space (25) to accommodate the cartridge (50), —wherein the cartridge holder (20) and the body (30) comprise an elongated shape and extend along an axial longitudinal direction (1, 2), —wherein the cartridge holder (20) has an insert section (21) at a proximal end (23), —wherein the body (30) has a receptacle (31) at a distal end (33) to receive the insert section (21) of the cartridge holder (20), —wherein the body (30) comprises a first latch element (34) on an inside (32) of a sidewall (32) of the receptacle (31), —wherein the cartridge holder (20) comprises a first through recess (24) in a sidewall (22) of the insert section (21) which through recess (24) is configured to receive the first latch element (34

Abstract: A needleless injector includes a main body, a syringe portion, a piston portion, an igniting device, and a pressing member. The pressing member is formed so as to have a part displaceable toward the piston portion while the part being kept from returning to the igniting device side upon receiving the ejection energy from the igniting device, and presses the piston portion toward the plunger based on displacement of the part. In addition, while the piston portion is pressed by the pressing member, the elastically deformable part is partly or entirely recovered from the elastic deformation from a most compressed state by the pressing force received from the pressing member so as to push the output portion toward the plunger. Accordingly, the injector achieves efficient ejection of the injection objective substance in order to deliver the injection objective substance to an injection target area while the injector is designed compact.

Abstract: Example syringe handles including a hub portion and a grip portion. The hub portion includes an outer surface, an inner surface configured to receive a portion of a syringe body, and a top and bottom surface each being adjacent to both the outer surface and the inner surface. The grip portion includes a first and a second arm, each connected to and extending from the outer surface of the hub portion. The first arm includes a distal end biased toward the top surface of the hub portion and the second arm includes a distal end biased toward the top surface of the hub portion.

Abstract: A monitoring feature, such as, for example, a pen cap, for an insulin delivery device may include at least one circuit adapted to detect at least one of a capping or decapping of the pen cap from an insulin pen and a processor for using information to the at least one of a capping or decapping of the pen cap. A monitoring feature for an insulin delivery device includes at least one circuit adapted to detect use of the insulin delivery device.

Abstract: One or more embodiments of the disclosure relate, generally, to a system to assist with manual dosing of insulin. Such a system may include a glucose sensor system, a reusable insulin dosing detector, and a recommendation system. The reusable insulin dosing detector may be configured to be reversibly connectable to a disposable component that may form part of an insulin manual delivery assembly. The reusable insulin dosing detector may be configured to detect insulin delivery associated with the insulin manual delivery assembly. The recommendation system may be configured to analyze blood glucose data and determine adjustments to insulin therapy settings.

Abstract: One or more embodiments of the disclosure are related, generally, to a reusable accessory for a manual medication delivery device. Such a reusable accessory may include a wireless communication interface, a detection circuitry, and a recommendation system. In one or more embodiments, an adapter may be configured to reversibly couple such a reusable accessory to a manual medication delivery device. Dosing events may be detected that are associated with dosing at the manual medication delivery device. Dose recommendations may be provided responsive to analyte measurements and/or dosing events.

Abstract: The disclosure provides a reading device (2, 20) adapted to read-out infrared readable data (D, D10) provided by a covered part (1.1.1.2, 10.1.1.2) of a movable component (1.1, 10.1) of a drug delivery device (1, 10), wherein the reading device (2, 20) comprises—at least one electromagnetic radiation source (2.2, 20.2) configured to emit infrared radiation and adapted to illuminate the infrared readable data (D, D10) on the covered part (1.1.1.2, 10.1.1.2),—at least one optical sensor unit (2.3, 20.3) configured to detect infrared radiation reflected from the covered part (1.1.1.2, 10.1.1.2) of the movable component (1.1, 10.1) and—at least one processing unit (2.4, 20.4) configured to determine a data value of the infrared readable data (D, D10) as a function of the detected reflected infrared radiation. The disclosure further provides a drug delivery device (1, 10) and a drug delivery device (1, 10) in combination with the reading device (2, 20).

Abstract: One or more embodiments of the disclosure relate, generally, to a replacement pen cap for a medication injection pen comprising at least one temperature sensor for monitoring a temperature of a medication, detect dosing events, and determine that medication may be denatured based on temperature data, received analyte measurement data prior, and the detected dosing events.

Abstract: A preferred method to obtain a painless or near painless needle 8 penetration is disclosed to be in the following manner: Applying electric current using a TENS device in conjunction with physically stimulating the injection site at a frequency that is dependent on the frequency of the electric current applied to the injection site, followed by a needle 8 penetration into the skin 2.

Abstract: An assistive device for subcutaneous injections or implants. The assistive device is placed under a blood pressure cuff that displaces the skin and subcutaneous tissues of a patient at an insertion site in order to allow guided insertion of a needle or implant applicator into a subcutaneous fat layer. The skin and subcutaneous tissue is displaced or drawn, via pressure applied by the blood pressure cuff, through an injection window of a device body into a hollow cavity of the device body. A guide channel leads from a front side of the device body into the hollow cavity, and an applicator of an adapter is inserted through the guide channel into the subcutaneous fat layer.

Abstract: An improved dry-powder inhalation device having a casing having an air inlet located at a first terminus; a powder delivery port located at a second terminus, which is positioned distal to the air inlet; and an elongated support panel located within an interior of the casing and being fitted within the casing so as to partially rotate therein about a single axis. The casing has at least one compartment containing dry-powder located proximally to the second terminus, and the support panel has a plurality of needle-like structures located proximal to the delivery port and arranged opposite the dry-powder compartment. The compartment with a dry-powder includes a cover encasing the dry-powder, whereby airflow through the device causes the elongated support panel to partially rotate repeatedly within the casing, whereby the plurality of needle-like structures strike the covered compartment, causing the dry-powder to be released into the airflow.

Abstract: Cap for bottle for rinsing nose, suitable for standard water bottle. The device comprises a body portion to be attached to the top of the bottle, comprising a cylindrical void for the threaded portion of the bottle, and one-way fluid valve attached to a void extending from the cylindrical void through the body portion. The body portion also includes one-way air valve to allow the entry of air into the bottle because of the negative pressure in it. A top portion is removably or openably attached to the body portion, comprising tubular opening starting near the body portion and extending through the top portion, wherein the top portion is configured so that it has a tip to be contacted with the user's nasal cavities and the top portion has as pressure zone for closing the fluid fluid valve by applying a pressure to said pressure zone.

Abstract: Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system.

Abstract: A breathing bag (20) has a tray section (21) and a bag section (22). The tray section (21) and the bag section enclose an inner volume (24) of variable size, the bag section dipping at least partially into the tray section to reduce the size of the inner volume. A system (10) includes the breathing bag, for a closed-circuit respirator (100), with a dispensing valve unit (40) having a dispensing valve (41) providing a quantity of gas in a breathing circuit. An actuating unit (42) is functionally connected mechanically to the dispensing valve for actuating the dispensing valve. A lever component (50) is functionally connected mechanically to the actuating unit for activating the actuating unit. A closed-circuit respirator has the system including the breathing bag and the dispensing valve unit. A process is provided for mounting the system, including breathing bag and dispensing valve unit, in the closed-circuit respirator.

Abstract: In certain embodiments, a ventilator may provide interactive guidance for obtaining a subject's expiratory flow limitation results. In some embodiments, the ventilator may cause a progressive color component to be presented, where the progressive color component indicates a progression from one color proximate one side of the progressive color component to another color proximate another side of the progressive color component. The ventilator may cause a forced oscillation to be continuously applied to an airway of the subject for a time period. The ventilator may monitor the subject's degree of expiratory flow limitation based on output signals generated by one or more sensors as the forced oscillation is continuously applied for the time period. The ventilator may cause, based on the monitoring, a movable component's position on the progressive color component to be continuously updated during the time period to indicate the degree of expiratory flow limitation.

Abstract: Examples described herein include multiple control systems for medical devices, such as medical ventilators. Examples of multiple control of a medical ventilator in an isolation room are described.

Abstract: It is the object of the invention, which relates to a tracheal tube (1) and a method for producing a tracheal tube (1), to provide a tracheal tube (1) with a connector (3), wherein the connector (3) is connected to a curved tube (2) by way of a rotatable and pivotable connection that can be easily realized. This object is solved with a device having a joint head part (4) of a ball joint arranged on first end of the connector (3) facing the curved tube (2), a first partial socket (2.1) of the ball joint arranged on a first end of the curved tube (2) facing the connector (3), a locking socket (5) arranged as a second partial socket of the ball joint, and a locking ring (6) arranged for connecting the locking socket (5) with the curved tube (2).

Abstract: A method of determining facial metrics of a person includes: receiving a request that the person requires a mask; navigating an autonomously operable vehicle to the person using at least one imaging device; capturing a number of images of the person using the at least one imaging device; and determining facial metrics of the person from the number of images. The method may be further employed in a method for identifying a mask for the person which further includes determining a mask for the user from the facial metrics; and identifying the mask to the person.

Abstract: A method of determining facial metrics of a patient includes: capturing a first image of the patient with an image capturing device positioned in a first known position with the assistance of a positioning device, capturing a second image of the patient with the image capturing device positioned in a second known position different that the first known position with the assistance of the positioning device, and determining facial metrics of the patient by analyzing the first image and the second image.

Abstract: An interface device for delivering a flow of a treatment gas to an airway of a patient includes: a conductive element positioned on a surface such that the conductive element directly contacts the patient when the interface device is positioned on the patient for delivering the flow of the treatment gas to the airway of the patient; and a conductive pathway extending from a first end which is electrically connected to the conductive element to an opposite second end which is structured to be electrically connected to earth ground.

Abstract: A conduit for delivering a supply of gas under a positive pressure includes a conduit wall having a first conduit end and a second conduit end. The first conduit end is adapted to be attached to the supply of gas. The conduit wall is deformable between (a) an open condition in which the conduit wall defines a conduit passage along which the supply of gas can travel between the first conduit end to the second conduit end, and (b) a collapsed condition in which the conduit wall substantially collapses the conduit passage.

Abstract: A conduit for delivering a supply of gas under a positive pressure includes a conduit wall having a first conduit end and a second conduit end. The first conduit end is adapted to be attached to the supply of gas. The conduit wall is deformable between (a) an open condition in which the conduit wall defines a conduit passage along which the supply of gas can travel between the first conduit end to the second conduit end, and (b) a collapsed condition in which the conduit wall substantially collapses the conduit passage.