Patents Issued in July 2, 2019
  • Patent number: 10335039
    Abstract: In one embodiment, the invention relates to a processor based method for generating positional and other information relating to a stent in the lumen of a vessel using a computer. The method includes the steps of generating an optical coherence image data set in response to an OCT scan of a sample containing at least one stent; and identifying at least one one-dimensional local cue in the image data set relating to the position of the stent.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 2, 2019
    Assignee: LIGHTLAB IMAGING, INC.
    Inventor: Chenyang Xu
  • Patent number: 10335040
    Abstract: A medical device for the measurement of brain temperature data through the Abreu brain thermal tunnel (ABTT) is described. Brain temperature measurement is the key and universal indicator of both disease and health equally, and is the only vital sign that cannot be artificially changed by emotional states. Currently, brain temperature is difficult to measure. However, the present disclosure describes a device that readily locates the Abreu brain thermal tunnel, and is configured to provide a non-contact temperature reading of the brain. Embodiments of the disclosed device enable an individual to measure their own temperature and enable medical professionals to measure the temperature of others.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: July 2, 2019
    Assignee: Geelux Holdings, Ltd.
    Inventor: Marcio Marc Abreu
  • Patent number: 10335041
    Abstract: Non-invasive methods and systems for detection of cancer or arterial vascular disorder involving administering to an individual a composition comprising noble metal nanoparticles that accumulate in a cancerous or injured vascular tissue; optically irradiating an area of a tissue suspected of being a cancerous or injured vascular tissue with a light source outputting an optical signal of at least one wavelength; and measuring diffusion reflection of the area of the irradiated tissue using at least one detector, whereby detection from the measured diffusion reflection of accumulation of the noble metal nanoparticles in this area indicates that the irradiated tissue is a cancerous or injured vascular tissue.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: July 2, 2019
    Assignee: BAR ILAN UNIVERSITY
    Inventors: Dror Fixler, Rinat Ankri
  • Patent number: 10335042
    Abstract: The present system is directed in various embodiments to methods, devices and systems for sensing, measuring and evaluating compliance in a bodily conduit. In other embodiments, the methods, devices and systems sense, measure, determine, display and/or interpret compliance in a bodily conduit and/or a lesion within the bodily conduit. In all embodiments, the sensing, measuring, determining, displaying and/or interpreting may occur before, during and/or after a procedure performed within the bodily conduit. An exemplary conduit comprises a blood vessel and an exemplary procedure comprises a vascular procedure such as atherectomy, angioplasty, stent placement and/or biovascular scaffolding.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: July 2, 2019
    Assignee: Cardiovascular Systems, Inc.
    Inventors: Victor L. Schoenle, Thomas B. Hoegh, Bruce J. Persson, Kayla Eichers, Matthew Tilstra, Richard C. Mattison, Joseph P. Higgins, Michael J. Grace, Matthew Saterbak, Matthew D. Cambronne, Robert E. Kohler
  • Patent number: 10335043
    Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: July 2, 2019
    Assignee: Thomas Jefferson University
    Inventors: Apurva Jain, Jeffrey I. Joseph, Nance Dicciani, Denise Devine, David Demmer
  • Patent number: 10335044
    Abstract: The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘Composite Method’, is carried out with a body-worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. A network of body-worn sensors, typically placed on the patient's right arm and chest, connect to the body-worn monitor and measure time-dependent ECG, PPG, accelerometer, and pressure waveforms. The disposable sensors can include a cuff that features an inflatable bladder coupled to a pressure sensor, three or more electrical sensors (e.g. electrodes), three or more accelerometers, a temperature sensor, and an optical sensor (e.g., a light source and photodiode) attached to the patient's thumb.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: July 2, 2019
    Assignee: SOTERA WIRELESS, INC.
    Inventors: Matthew Banet, Marshal Dhillon, Devin McCombie
  • Patent number: 10335045
    Abstract: Recent studies in computer vision have shown that, while practically invisible to a human observer, skin color changes due to blood flow can be captured on face videos and, surprisingly, be used to estimate the heart rate (HR). While considerable progress has been made in the last few years, still many issues remain open. In particular, state-of-the-art approaches are not robust enough to operate in natural conditions (e.g. in case of spontaneous movements, facial expressions, or illumination changes). Opposite to previous approaches that estimate the HR by processing all the skin pixels inside a fixed region of interest, we introduce a strategy to dynamically select face regions useful for robust HR estimation. The present approach, inspired by recent advances on matrix completion theory, allows us to predict the HR while simultaneously discover the best regions of the face to be used for estimation.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 2, 2019
    Assignees: Universita degli Studi Di Trento, Fondazione Bruno Kessler, The Research Foundation for the State University of New York, University of Pittsburgh of the Commonwealth of Higher Education
    Inventors: Niculae Sebe, Xavier Alameda-Pineda, Sergey Tulyakov, Elisa Ricci, Lijun Yin, Jeffrey F. Cohn
  • Patent number: 10335046
    Abstract: A physiological detection system including an image sensor, a converting unit, a retrieving unit and a processing unit is provided. The image sensor includes a plurality of pixels respectively configured to output a PPG signal. The converting unit is configured to convert a plurality of PPG signals of a plurality of pixels regions to a plurality of frequency domain signals. The retrieving unit is configured to respectively retrieve a spectral energy of the frequency domain signals corresponding to each of the pixel regions. The processing unit is configured to construct a 3D energy distribution according to the spectral energies.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: July 2, 2019
    Assignee: PIXART IMAGING INC.
    Inventors: Sen-Huang Huang, Ren-Hau Gu
  • Patent number: 10335047
    Abstract: In some examples, processing circuitry of a medical device system determines, for each of a plurality of periods, a plurality of heart rates of a patient based on a cardiac electrogram signal, and identifies a first subset of the plurality of heart rates as nighttime heart rates and a second subset of the plurality of heart rates as resting heart rates. The processing circuitry determines a representative nighttime heart rate based on the first subset of the plurality of heart rates, determines a representative resting heart rate based on the second subset of the plurality of heart rates, and determines a nocturnal dip base on the representative nighttime heart rate and the representative resting heart rate.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: July 2, 2019
    Assignee: Medtronic, Inc.
    Inventor: Bruce D. Gunderson
  • Patent number: 10335048
    Abstract: Provided herein are methods and apparatuses for determining a level of cellular metabolic activity for a region of interest in order to detect and map on-going gliovascular unit metabolic activity using high-resolution 1H2O MRI. In one example approach, a computer-implemented method includes receiving a first set of DCE-MRI time-course data for a region, wherein a contrast agent is administered prior to imaging, identifying a region of interest from the first set of DCE-MRI time-course data for further analysis, performing shutter-speed pharmacokinetic analysis of the time-course data associated with the region of interest using computer-implemented software to obtain a finite and non-zero mean water molecule capillary lifetime in the region of interest, and indicating a level of cellular metabolic activity in the brain based on the mean water molecule capillary lifetime.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: July 2, 2019
    Assignee: Oregon Health & Science University
    Inventors: William Rooney, Charles Springer, Jr., Xin Li
  • Patent number: 10335049
    Abstract: Example embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. Sampling is performed in response to a fast imaging with steady state free precession (MRF-FISP) pulse sequence having an unbalanced gradient that dephases transverse magnetization. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals, and a characterization logic that characterizes a resonant species in the object as a result of comparing acquired signals to reference signals. The unbalanced gradient in the MRF-FISP pulse sequence reduces sensitivity to B0 in homogeneity.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: July 2, 2019
    Assignee: Case Western Reserve University
    Inventors: Mark Griswold, Yun Jiang, Dan Ma
  • Patent number: 10335050
    Abstract: An apparatus and method are provided for determining the speed of propagation of a pulse wave. The apparatus includes at least one pulse wave sensor positionable on a finger and a toe of a subject and a processing and calculation unit configured to determine the time that the pulse wave reaches the finger and the time that the pulse wave reaches the toe of the subject. The unit calculates a time value, designated “aortic transit time”, as a function of the difference between the times that the pulse wave reaches the toe or the finger of the subject, and calculates a speed, designated “aortic pulse wave velocity”, as a function of the aortic transit time. The calculation includes division of a value, designated “aortic length”, as a function of the height and age of the subject, by the aortic transit time.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: July 2, 2019
    Inventor: Magid Hallab
  • Patent number: 10335051
    Abstract: A method including measuring cardiac beats in signals at one or more electrodes on a catheter in response to electrical activity in the heart cavity and collecting a plurality of additional data signals related to the cardiac beats, computing criteria that is used to characterize beat morphology of a cardiac beat in the plurality of additional data signals, the criteria based on a comparison of the plurality of additional data signals and a beat template, selecting a subset of less than all of the cardiac beats in the signals measured by the one or more electrodes by determining, based on the criteria, whether to select the cardiac beat and include beat data for the cardiac beat, and determining physiological information based on the selected subset of less than all of the cardiac beats in the signals measured by the one or more electrodes.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: July 2, 2019
    Assignee: Rhythmia Medical, Inc.
    Inventors: Doron Harlev, Rotem Eldar
  • Patent number: 10335052
    Abstract: A device for analyzing electrophysiological data is disclosed. The device generates a signal indicative for a presence of a pulmonary vein potential component using processing means adapted for performing a stepwise analysis of the electrophysiological data. A corresponding method and computer application for installing on a device are also described.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: July 2, 2019
    Assignee: UNIVERSITEIT GENT
    Inventor: Milad El Haddad
  • Patent number: 10335053
    Abstract: Embodiments of the present disclosure describe methods of adaptive arrhythmia detection comprising monitoring ECG signals of a patient via a patient medical device, detecting and capturing ECG segments based on a heart rate threshold and an initial sensitivity level associated with the heart rate threshold; and adjusting the sensitivity level based on previously captured ECG segments. Embodiments of the present disclosure further describe patient medical devices comprising one or more electrodes and sensing circuitry for monitoring ECG signals of a patient; and a processing module configured to receive the monitored ECG signal, wherein the processing module detects and captures ECG segments based on a plurality of heart rate thresholds and one or more sensitivity levels associated with each of the heart rate thresholds, and adjusts at least one of the one or more sensitivity levels associated with each of the heart rate thresholds.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: July 2, 2019
    Assignee: Medtronic Monitoring, Inc.
    Inventors: Rodolphe Katra, Niranjan Chakravarthy
  • Patent number: 10335054
    Abstract: A diagnostic method for monitoring changes in a fluid medium in a patient's head. The method includes positioning a transmitter at a first location on or near the patient's head, the transmitter generates and transmits a time-varying magnetic field into a fluid medium in the patient's head responsive to a first signal; positioning a receiver at a second location on or near the patient's head offset from the transmitter, the receiver generates a second signal responsive to a received magnetic field at the receiver; transmitting a time-varying magnetic field into the fluid medium in the patient's head in response to the first signal; receiving the transmitted magnetic field; generating the second signal responsive to the received magnetic field; and determining, a phase shift between the transmitted magnetic field and the received magnetic field for a plurality of frequencies of the transmitted time-varying magnetic field.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: July 2, 2019
    Assignee: CEREBROTECH MEDICAL SYSTEMS, INC.
    Inventors: Richard Warren Wyeth, Mitchell Elliott Levinson
  • Patent number: 10335055
    Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 2, 2019
    Assignee: Orthosensor Inc.
    Inventors: Marc Stein, Martin Roche
  • Patent number: 10335056
    Abstract: A sensor for electrically measuring a force distributed unevenly across a measurement surface of the sensor includes a spring device between a measurement surface and a counter-surface. A first measuring element is arranged in or on the measurement surface and a second measuring element is arranged in or on the counter-surface, the elements substantially completely covering these surfaces in each case. The measuring elements include capacitor plates, and are designed such that the measuring signal can be generated from a distance between the measuring elements. The spring device has a large number of elastically designed spring members which are arranged spaced apart from each other by gaps so that each spring member upon loading by the force can deform into the gaps. This arrangement makes it is possible to measure unevenly distributed forces between bodies which may be of very different forms.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: July 2, 2019
    Assignees: Novel GmbH
    Inventors: Peter Seitz, Ahmad Dahrouj
  • Patent number: 10335057
    Abstract: Provided are, among other things, systems, apparatuses methods and techniques for performing a semi-autonomous and/or autonomous measurement of the depth of a hole drilled into bone during a medical/surgical procedure. One such apparatus is activated by a tactile command, provides a digital readout of hole depth, and includes a controller module, a stepper/encoder unit, a linear actuator, and a position sensor.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: July 2, 2019
    Assignee: Exaxion Scientific, LLC
    Inventors: Christopher Pagnanelli, James F Bauer
  • Patent number: 10335058
    Abstract: A chair enabling standardized performance testing under Timed Up and Go procedures. The chair has a seat portion, a base portion, a support element, a force sensor, a timer, and a processor. The processor initiates timing of the standardized performance test in response to receiving an output signal corresponding to a force value less than or equal to a minimum threshold force. The processor ceases timing of the standardized performance test in response to receiving an output signal corresponding to a force greater than or equal to a maximum threshold force. The processor determines a time interval of the standardized performance test based upon the output of the timer.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: July 2, 2019
    Assignee: The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada, Las Vegas
    Inventors: Szu-Ping Lee, Robbin Hickman, Janet Dufek
  • Patent number: 10335059
    Abstract: There is provided a fall detection system for use in detecting falls by a user, the fall detection system comprising a processing unit configured to determine context information about the user and/or the environment in which the user is located, and to increase the sensitivity of a fall detection algorithm used to detect falls by a user in the event that the determined context information indicates that the user is or may be at an increased risk of falling, the increase in sensitivity occurring while the increased risk of falling is indicated by the determined context information.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: July 2, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Janneke Annegarn, Warner Rudoph Theophile Ten Kate, Heribert Baldus
  • Patent number: 10335060
    Abstract: An activity band designed to be wearable 24 hours a day, and able to monitor the user's activity level when awake and asleep, comprising an accelerometer to detect motion of a user, a first interface to enable the activity band to be coupled to a computer system, and an analysis logic to analyze the user's motion.
    Type: Grant
    Filed: June 19, 2010
    Date of Patent: July 2, 2019
    Assignee: DP TECHNOLOGIES, INC.
    Inventors: Philippe Kahn, Arthur Kinsolving
  • Patent number: 10335061
    Abstract: A sensor system detects hand-to-mouth behavior. The system includes an electrical bio-impedance spectrometer and an inertial measurement unit. The sensor system may be worn on the forearm. The sensor system recognizes hand-to-mouth behavior in real-time, facilitating monitoring and immediate interventions An electrode positioning strategy optimizes the device's sensitivity and accuracy. Machine learning algorithms are leveraged to infer the hand-to-mouth detection. A prototype of the sensor system achieves 92% detection accuracy for recurrent usage by a single user and 90% accuracy for users that have not been previously encountered.
    Type: Grant
    Filed: October 22, 2016
    Date of Patent: July 2, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Asaph Azaria, Brian Mayton, Joseph Paradiso
  • Patent number: 10335062
    Abstract: An electronic device is provided which includes a housing including a first face that faces a first direction and a second face that faces a second direction, which is opposite to the first direction, the housing including a transparent cover that forms at least a portion of the first face, a display disposed between the first face and the second face of the housing and exposed through the transparent cover, a fingerprint sensor disposed between the transparent cover and the display, a touch sensor disposed between the fingerprint sensor and the display, and a pressure sensor disposed between the display and the second face of the housing.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: July 2, 2019
    Assignee: Samsung Electronics Co., Ltd
    Inventors: Han-Vit Kang, Ho-Kyung Kang, Byeong-Cheol Kim, Jung-Won Kim, Jeong-Sik Jeong, Kwang-Tai Kim, Hyung-Sup Byeon, Hyun-Ju Hong
  • Patent number: 10335063
    Abstract: Systems and methods for applying and/or receiving electrical, magnetic, magnetoelectric, vibratory, or electromagnetic signals to biological tissues are described. In some embodiments, one or more of a conductive tip and a base may be provided. The tip may include a channel and an outer surface that approximates a portion of a sphere or cone and may be sized to fit within a user's ear. The base may be configured to be coupled to the tip and may include a conductor in electrical contact with the tip such that an electrical signal may pass between the base and the tip.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 2, 2019
    Assignee: COMBOBUTRONICS LLC
    Inventors: Kevin Mauro, Grace Taylor
  • Patent number: 10335064
    Abstract: Systems and methods for applying and/or receiving electrical, magnetic, magnetoelectric, vibratory, or electromagnetic signals to biological tissues are described. In some embodiments, one or more of a body, a conductor, an electrode, and a magnetic element may be provided. The conductor may be configured to be electrically coupled to at least one of a power source and a detector. The electrode may include a surface configured to contact a biological tissue portion and apply and/or receive an electrical signal to and/or from the biological tissue portion. The magnetic may selected from a group consisting of a magnet, a toroid, a conductive coil, a magnetic powder, and a magnetic fluid.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 2, 2019
    Assignee: COMBOBUTRONICS LLC
    Inventors: Kevin Mauro, Grace Taylor
  • Patent number: 10335065
    Abstract: Systems and methods for a continuous monitoring of analyte values received from an analyte sensor system are provided. One method for a wireless data communication between an analyte sensor system and a mobile device involves storing identification information associated with a transceiver of the analyte sensor system, the identification information entered by a user of the mobile device via a custom application running on the mobile device; causing the custom application to enter a background mode; searching for advertisement signals; receiving an advertisement signal from the transceiver; authenticating the transceiver based on the identification information; prompting the user to bring the custom application to a foreground mode; causing the custom application to request a confirmation from the user that a data connection with the transceiver is desired; receiving the confirmation from the user; and completing the data connection with the transceiver.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: July 2, 2019
    Assignee: DexCom, Inc.
    Inventors: Jose Hector Hernandez-Rosas, Shawn Larvenz, Mark Dervaes, Indrawati Gauba, Michael Robert Mensinger, Eric Cohen, Brian Christopher Smith, Jorge Valdes, Jacob S. Leach
  • Patent number: 10335066
    Abstract: An inserter assembly for continuous glucose monitoring with medication delivery capability where the assembly has a deployment button containing a needle deployment mechanism having a sharp held in a pre-release position, a housing body in which the deployment button is movably received within a top end of the housing body, the housing body having a sensor deployment assembly containing a lumen and a sensor disposed within the lumen and extending out of the lumen to a circuit board that is part of the sensor deployment assembly, the sensor deployment assembly matingly connected to the sharp where the sharp extends beyond the sensor deployment assembly and contains the sensor not fixedly attached to the sharp, and a sensor housing releasably received within a lower end of the housing body, the sharp extending into a sensor deployment assembly recess within the sensor housing and directly above a sensor opening in a bottom of the sensor housing.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: July 2, 2019
    Inventors: Thomas H. Peterson, Scott P. Cionek, Anthony Florindi, Julian I. Hart
  • Patent number: 10335067
    Abstract: An optical unit (100) includes a light-emitting portion (10) that irradiates an analysis target with light, light-receiving portions (20) that receive light that has been reflected or diffused by the analysis target, a mounting substrate (30) on which these portions are mounted, and a plate-shaped member (40) having optical transparency. The plate-shaped member (40) is arranged so as to cover the light-emitting portion (10) and the light-receiving portions (20) that are mounted on the mounting substrate (30). Positions of the light-emitting portion (10), the light-receiving portions (20), and the plate-shaped member (40) are set such that, in the case where the analysis target is in contact with the plate-shaped member (40), light emitted from the light-emitting portion (10) is incident on two or more of the light-receiving portions (20) after being reflected or diffused by the analysis target.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: July 2, 2019
    Assignee: NEC SOLUTION INNOVATORS, LTD.
    Inventor: Ippei Kamimura
  • Patent number: 10335068
    Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: July 2, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Jeroen Poeze, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Ferdyan Lesmana, Massi Joe E. Kiani
  • Patent number: 10335069
    Abstract: A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 2, 2019
    Assignee: ViOptix, Inc.
    Inventors: Kate LeeAnn Bechtel, Lester John Lloyd
  • Patent number: 10335070
    Abstract: Devices and systems have a sensor probe configured to measure tissue oxygen saturation in the intestine or mesentery. The devices and systems can determine the oxygenation state of the entire thickness of the intestine or mesentery. Embodiments of the invention also include methods for inducing a temporary ischemic period in an intestine or mesentery tissue and analyzing changes in oxygen saturation of the tissue during the temporary ischemic period or during a recovery phase. The devices, systems, and methods can be applied in diagnosing intestinal ischemia in a patient, as well as in monitoring tissue oxygen saturation of the intestine or mesentery during or after a surgical procedure.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: July 2, 2019
    Assignee: ViOptix, Inc.
    Inventors: Larry C. Heaton, II, Robert E. Lash, Jimmy Jian-min Mao
  • Patent number: 10335071
    Abstract: A physiological parameter measuring apparatus is configured to perform a screening for a likelihood of the critical congenital heart disease, based on the oxygen saturations at two locations on a body of a patient and the difference between the oxygen saturations, and to display the likelihood as a result of the screening. The physiological parameter measuring apparatus manages, with respect to each patient, a scheduled time for starting the screening, the result of the screening, and information relating to the patient. The physiological parameter measuring apparatus can display a first screen containing information relating to the scheduled time, a second screen for receiving the instruction to perform the screening, and a third screen containing the result of the screening. A physiological parameter measuring system includes sensors to be attached to the body at the two locations, and the physiological parameter measuring apparatus.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: July 2, 2019
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Norihiko Sugihara, Kazumasa Ito, Osamu Kamataki, Hiroko Hagiwara, Rie Muneshima
  • Patent number: 10335072
    Abstract: A patient monitor has multiple sensors adapted to attach to tissue sites of a living subject. The sensors generate sensor signals that are responsive to at least two wavelengths of optical radiation after attenuation by pulsatile blood within the tissue sites.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: July 2, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Ammar Al-Ali, Mohamed K. Diab, Massi E. Kiani, Robert James Kopotic, David Tobler
  • Patent number: 10335073
    Abstract: An electronic endoscope has normal and high-sensitivity image sensors. In a special mode for imaging an oxygen saturation level of blood, one of the normal and high-sensitivity image sensors is selected in accordance with a reflected light amount of special illumination light. When the normal image sensor is selected, the normal image sensor captures an image under irradiation with the special illumination light and outputs a second normal-sensor image. When an average pixel value of the second normal-sensor image is less than a first sensor selection threshold value, the use of the high-sensitivity image sensor is started. When the high-sensitivity image sensor is selected, the high-sensitivity image sensor captures an image under irradiation with the special illumination light and outputs a high-sensitivity-sensor image. When the average pixel value of the high-sensitivity-sensor image is more than a second sensor selection threshold value, the use of the high-sensitivity image sensor is stopped.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: July 2, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Toshihiko Kaku, Jin Murayama
  • Patent number: 10335074
    Abstract: A flexible sensor pad includes a cavity to hold a sensor unit with an attached cable. According to one aspect of the present invention, a light-shielding layer is coupled to a bottom surface of the sensor pad, surrounds the sensor unit, and extends past two sides of the sensor pad. A transparent adhesive layer is coupled to the light-shielding layer and extends past two sides of the light-shielding layer. Another light shielding layer is coupled to a top surface of the sensor pad and covers the sensor unit. The cable divides the sensor pad into a first side and a second side which are mirror images of each other.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: July 2, 2019
    Assignee: ViOptix, Inc.
    Inventors: Jimmy Jian-min Mao, Robert E. Lash
  • Patent number: 10335075
    Abstract: Systems and methods for processing sensor data and calibration of the sensors are provided. In some embodiments, the method for calibrating at least one sensor data point from an analyte sensor comprises receiving a priori calibration distribution information; receiving one or more real-time inputs that may influence calibration of the analyte sensor; forming a posteriori calibration distribution information based on the one or more real-time inputs; and converting, in real-time, at least one sensor data point calibrated sensor data based on the a posteriori calibration distribution information.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 2, 2019
    Assignee: DexCom, Inc.
    Inventors: Stephen J. Vanslyke, Naresh C. Bhavaraju, Lucas Bohnett, Arturo Garcia, Apurv Ullas Kamath, Jack Pryor
  • Patent number: 10335076
    Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 2, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
  • Patent number: 10335077
    Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 2, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
  • Patent number: 10335078
    Abstract: A method for separating and collecting cell-free plasma by finger stick that minimizes contamination with genomic DNA from a donor. The method comprising placing a tourniquet on one of the digits of the donor's finger to apply pressure, lancing the digit to create an incision in the digit, and collecting blood from the incision from the incision site. The collected blood is placed on a separation membrane wherein the separation membrane is in contact with a collection membrane and both the separation and collection membrane are inserted into a substrate configured to provide overlap between the membranes. A kit and instructions for carrying out the method is also provided.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: July 2, 2019
    Assignee: General Electric Company
    Inventors: Erik Leeming Kvam, Weston Blaine Griffin, Erin Jean Finehout, Ying Mao
  • Patent number: 10335079
    Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for analyzing data include: receiving data including responses, and lack thereof, for items of a cognitive test including multiple item-recall trials; processing the data using a stochastic model of a cognitive process, in which a conditional probability distribution of future states of the cognitive process depend upon a present state; and encoding a result of the processing on a non-transitory computer-readable medium for use in an assessment related to cognition; wherein the processing using the stochastic model includes representing recall or recognition of an item in the multiple item-recall trials using distinct cognitive states; and wherein the processing using the stochastic model includes adjusting separate memory storage and retrieval parameters for each of the distinct cognitive states in the modeled cognitive process to account for position of the items in each respective trial of the multiple item-recall trials.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: July 2, 2019
    Assignee: Medical Care Corporation
    Inventors: Gregory E. Alexander, William Rodman Shankle
  • Patent number: 10335080
    Abstract: A wearable sensor apparatus comprises a motion sensor configured to sense two or three dimensional movement and orientation of the sensor and a vibration sensor configured to sense acoustic vibrations. The apparatus includes means for attaching the motion sensor and the vibration sensor to a body. The sensor apparatus enables long term monitoring of mechanomyographic muscle activity in combination with body motion for a number of applications.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 2, 2019
    Assignee: Imperial Innovations Limited
    Inventors: Ravi Vaidyanathan, Niamh Nowlan, Richard Woodward, Sandra Shefelbine
  • Patent number: 10335081
    Abstract: An improved apparatus and method for interfacing a time variant waveform between two hardware environments. In one aspect, the invention comprises a circuit for accurately simulating the output of one or more types of sensing device (e.g., passive bridge pressure transducer) for use with a plurality of different monitoring and/or analysis devices, thereby obviating the need for specialized interface circuitry adapted to each different monitor/analyzer. In one exemplary embodiment, the sensing device comprises a non-invasive blood pressure monitor (NIBPM), which universally interfaces with prior art patient monitors via the interface circuit of the invention. In a second aspect of the invention, an improved NIBPM device incorporating the interface circuit is disclosed. An improved disconnect circuit adapted to sense the status of the electrical connection between the sensing device and monitor is also described.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: July 2, 2019
    Assignee: United States GTM Medical Devices
    Inventor: Ronald S. Conero
  • Patent number: 10335082
    Abstract: A medication delivery system for delivering medicament to a body of a user. The medication delivery system may include a housing having a plurality of medicament reservoirs therein, a first sensor configured to continuously monitor a parameter of the body, and a pump mechanism configured to pump medicament from each of the plurality of medicament reservoirs to a delivery mechanism having a portion disposed within the body of the user.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: July 2, 2019
    Assignee: Picolife Technologies, LLC
    Inventor: Farid Amirouche
  • Patent number: 10335083
    Abstract: A system for monitoring biosignals of a user includes a first end region, positionable proximate a first ear of a user and including a first sensor array; a second end region, positionable proximate a second ear of the user and including a second sensor array; an intermediate region, positionable on a neck region of the user; a coupling element configured to couple the first and second end regions to the intermediate region; and a first attachment element and a second attachment element. The first attachment element couples the first end region to a head-mounted accessory and the second attachment element couples the second end region to the head-mounted accessory. The first end region includes a first electrode and the second end region includes a second electrode, such that there is a fixed distance between the first and second electrodes.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: July 2, 2019
    Inventors: Courtland Keith Keteyian, Jinyong Kim
  • Patent number: 10335084
    Abstract: There has been no sufficient study to address an issue caused in the use of an open-air type audio device. Therefore, provided is an audio device with an actually useful organism sensor. In particular, the audio device includes an audio unit 10 to externally abut on the ear without being inserted thereinto, and an organism sensor unit 70 to be inserted into the ear.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: July 2, 2019
    Assignee: KYOCERA Corporation
    Inventors: Tomohiro Inagaki, Asao Hirano
  • Patent number: 10335085
    Abstract: The present invention is directed to a computer application for monitoring and tracking leg and foot movements and positions and a device for facilitating the computer tracking of the leg and foot movements. The application uses an accelerometer, gyroscope or other movement detectors in available devices such as a phone, movement tracker, personal music device, tablet computing device, other similar device or a device specifically designed to detect movements and positions and to track the movement and changes in position of the patient's leg and foot. The device can be held onto the patient's leg using a band type device that is easy to use and comfortable during sleep or by incorporation into a comfortable wearable band. The application includes a user interface and a backend for use by physicians or other healthcare staff to review and diagnose the patient's leg and foot movement patterns.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: July 2, 2019
    Assignee: The Johns Hopkins University
    Inventor: Richard P. Allen
  • Patent number: 10335086
    Abstract: An embodiment of a device includes at least one sensor, a determiner, and a notifier. The at least one sensor is configured to be located on a body portion of a subject and to sense an object. The determiner is configured to determine, in response to the sensor, whether the body portion may contact the object. The notifier is configured to notify the subject in response to the determiner determining that the body portion may contact the object. Such a device (e.g., attached to, or part of, a shoe) may be useful to warn a subject of a potential collision between an object (e.g., stairs, furniture, door jamb, curb, toy) and a body part (e.g., foot, toes) in which the subject has lost feeling, the ability to feel pain, or proprioception. And such a warning may help the subject to avoid inadvertently and repeatedly injuring the body part.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: July 2, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 10335087
    Abstract: Provided are a biosignal processing apparatus and a biosignal processing method. The biosignal processing apparatus includes: a first measurement module configured to detect a biosignal of a subject in a non-invasive manner in response to the biosignal processing apparatus being in contact with the subject; a second measurement module configured to measure a contact state with respect to the subject; and a controller configured to determine whether the contact state is equal to or greater than a reference value.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: July 2, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Joonhyung Lee, Sangkyu Kim, Seongho Cho
  • Patent number: 10335088
    Abstract: A biometric information detecting apparatus includes a bio-signal measurer including a light-emitting unit and a light-receiving unit, the light-emitting unit configured to emit an optical signal and the light-receiving unit configured to detect the optical signal that is modulated by a target object; a low-frequency signal obtainer configured to obtain a low-frequency signal from the bio-signal measured by the bio-signal measurer; and a signal processor configured to analyze biometric information from the bio-signal in response to determining that the low-frequency signal obtained from the bio-signal is within a reference range.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: July 2, 2019
    Assignees: SAMSUNG ELECTRONICS CO., LTD., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
    Inventors: Sangyun Park, Yongjoo Kwon, Younho Kim, Heechan Kim, Jonghyun Park, Byeongwook Yoo