Abstract: A method of formulating or concentrating a radiolabeled molecule or compound includes providing a microfluidic device having a sample layer containing a microfluidic channel formed therein, a porous membrane having a pore size of less than 0.5 ?m disposed on the sample layer and covering the microfluidic channel, and a gas flow layer having a gas-carrying channel formed therein, wherein the porous membrane is interposed between the sample layer and the gas flow layer. A fluid containing the radiolabeled molecule or compound is delivered into the microfluidic channel. Heat is applied to evaporate the fluid. A gas is passed through gas-carrying channel to remove evaporated fluid from the microfluidic device.

Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.

Abstract: This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.

Abstract: Described herein generally are sterilization devices that can allow sterilization of luminal connection ports. Methods of using these devices are also described.

Abstract: A method and apparatus for decontaminating substantially enclosed environments by using ultrasonic cavitation of a cleaning fluid to produce a low pressure, low air flow mist that can be activated by a nonthermal plasma actuator to create a cloud of activated hydroxyl species with the capacity to decontaminate articles, open surfaces or substantially enclosed spaces of pathogens, including bacteria, and other pathogenic microorganisms. An automated system and related non-transitory computer medium are also disclosed.

Abstract: A method and apparatus for decontaminating substantially enclosed environments by using ultrasonic cavitation of a cleaning fluid to produce a low pressure, low air flow mist that can be activated by a nonthermal plasma actuator to create a cloud of activated hydroxyl species with the capacity to decontaminate articles, open surfaces or substantially enclosed spaces of pathogens, including bacteria, and other pathogenic microorganisms. An automated system and related non-transitory computer medium are also disclosed.

Abstract: An apparatus includes a first production line configured to generate aqueous ozone with a first ozone concentration. The apparatus also includes an additional production line configured to generate aqueous ozone with an additional ozone concentration. The first production line and the additional production line include a flow switch, where fluid is configured to flow through the flow switch. The first production line and the additional production line include an ozone generator, where the ozone generator is configured to generate ozone when the fluid flows through the flow switch. The first production line and the additional production line include a fitting coupled to the flow switch and the ozone generator, where the fitting is configured to combine the generated ozone and the fluid to generate the aqueous ozone. The first production line is configured to generate aqueous ozone independently from the additional production line.

Abstract: A fill assembly sterilization method and system for a blow/fill/seal machine utilizes a closed loop circulation of sterilant containing gas. A typical sterilant is nitrogen dioxide in humidified air. The closed loop includes a shroud that defines a plenum and encloses the fill system. Optionally, at least one high efficiency particulate absorption (HEPA) filter is provided in the closed loop. Sterility assurance level of 10?6 can be achieved by subjecting the fill system to the sterilizing gas for at least 20 minutes at a temperature in the range of about 18° C. to about 30° C. Preferred sterilant gas is humidified air containing about 10 to about 20 milligrams of nitrogen dioxide per liter.

Abstract: A sterilization tray is disclosed. The sterilization tray comprises a basin and a platter including a depression and a port disposed through a terminal end of the depression. The basin and the platter define a chamber and the port defines a passage into the chamber. An adapter may be connected to the port to facilitate connection of an endoscope thereto. The tray and the endoscope may be disposed in a vacuum chamber of a sterilizer and subject to a sterilization cycle. A pressure differential may be created between the vacuum chamber and the first chamber. A sterilant may be drawn through the insertion tube and into the first chamber. The sterilant may also be drawn through the insertion tube and into the vacuum chamber.

Abstract: A sterilization tray is disclosed herein that may be used to facilitate preparation of an endoscope for sterilization and increase the likelihood that the endoscope will be properly sterilized. The sterilization tray may be fabricated from a flexible and vapor-permeable sheet. Cutouts may be disposed through the sheet to define standoffs that are foldable away from the sheet. A first standoff may include a first contoured portion disposed therein. The tray may also include a second standoff that has a second contoured portion and a third contoured portion disposed therein. The third standoff may include a locking tab disposed on a free end of the third standoff. A positioning tab may also be disposed on the third standoff. The sterilization tray may also include a dry booster to which an endoscope may be connected.

Abstract: Ultraviolet illumination with optical elements to irradiate objects and/or fluid for purposes of sterilization, disinfection, and/or cleaning. The objects and/or fluid can be irradiated using an ultraviolet illuminator having at least one ultraviolet light emitting source. An ultraviolet transparent housing encapsulates the at least one ultraviolet light emitting source. The ultraviolet transparent housing includes an ultraviolet transparent material that emits ultraviolet light from the at least one ultraviolet light emitting source while preventing humidity from penetrating the ultraviolet transparent housing and damaging the at least one ultraviolet light emitting source. At least one ultraviolet transparent optical element is located about the ultraviolet transparent housing interspersed with the ultraviolet transparent material.

Abstract: Methods, devices and program products are provided for a medical instrumentation storage cabinet. First and second instrumentation retention trays are configured to receive surgical instruments. The housing includes a top plate, a bottom shelf and at least one intermediate shelf there between. The bottom and intermediate shelfs and the first and second instrumentation retention trays include a plurality of holes there through to allow passage of a sterilization medium during a sterilization process. Standoffs are distributed about a perimeter of the housing. The standoffs separate the intermediate shelf from the top plate and bottom shelf to define first and second tray storage areas there between. The first and second tray storage areas have a shape and dimension to receive the first and second instrumentation retention trays. The standoffs are spaced apart from one another to define tray passages there between.

Abstract: A system for applying a novel odor abating solution to an odor-emitting surface includes a storage compartment comprising a solution of iodine having a concentration of at least 0.0005% by total weight of the solution of I2; a misting system having mist nozzles that are supported over the odor-emitting surface, creating an aerial environment between the odor-emitting surface and the mist nozzles; misting nozzles configured to spray droplets of the solution into the aerial environment over the odor-emitting surface so that, in absence of any air movement exceeding 1 kilometer/hour, at least 75% of the droplets are suspended in the aerial environment over the odor-emitting surface for at least 10 seconds, allowing at least 1% by weight of the I2 in the solution to react with emitted odor before the 75% of the droplets are deposited on the odor-emitting surface. The odor-emitting surface may be within a waste transfer station.

Abstract: An air purification assembly is described. The air purification assembly includes an intake portion, a flow apparatus coupled to the intake portion; and a chamber portion coupled to the flow apparatus. The intake portion includes a surface and at least one first opening in the surface such that the intake portion is enabled to receive contaminated air flow through the at least one first opening. The chamber portion includes at least one second opening and further comprises an activated nonmetallic element and an ultraviolet (UV) light assembly. The flow apparatus is adapted to draw contaminated air into the air purification assembly through the at least one first opening and direct the contaminated air out of the air purification assembly through the second openings.

Abstract: Wound dressing compositions comprising of a bioresorbable sponge encapsulated within a polysaccharide envelope. The bioresorbable sponge is preferably comprised of collagen and oxidised regenerated cellulose. The outer polysaccharide envelope is preferably comprised of chitosan. The outer polysaccharide envelope functions to modulate the rate at which the bioresorable sponge breaks down within a wound.

Abstract: The present invention provides a bone cement composition. The bone cement composition includes a developing particle, an acrylic polymer, and an acrylic monomer, wherein a specific surface area of the developing particle is in a range from about 0.1 m2/g to about 5 m2/g. The present invention further provides a bone cement composition kit. The bone cement composition kit includes a power component and a liquid component, respectively stored in separate containers, wherein the power component includes a developing particle and an acrylic polymer, and the liquid component includes an acrylic monomer. A specific surface area of the developing particle is in a range from about 0.1 m2/g to about 5 m2/g.

Abstract: Provided is a biocompatible alloy having low magnetic susceptibility and excellent mechanical properties. The biocompatible alloy according to the present invention contains: Zr as a main component; Nb of not less than 0.1% by mass and not greater than 25% by mass; Mo of not less than 0.1% by mass and not greater than 25% by mass; and Ta of not less than 0.1% by mass and not greater than 25% by mass. A total content of Nb, Mo, and Ta in the biocompatible alloy is not less than 2% by mass and not greater than 50% by mass. The biocompatible alloy has a mass susceptibility of not greater than 1.50×10?6 cm3/g. The biocompatible alloy has a Young's Modulus of not greater than 100 GPa. Various biocompatible implants and medical devices can be manufactured from the biocompatible alloy.

Abstract: A fiber-based surgical implant stabilized against fraying, includes a thermally crimped flat-knitted fabric of a biocompatible, optionally biodegradable, polymer material having a glass transition temperature or other thermally induced secondary conformational mobility threshold in the temperature range of from 20° C. to +170° C. Also disclosed is a corresponding fabric and methods of producing the implant and the fabric.

Abstract: A biomaterial implant may include a collagen membrane. The biomaterial implant may further include a plurality of nanoparticles embedded in the collagen membrane. Furthermore, at least one nanoparticle of the plurality of nanoparticles may include a polymer shell and a bio-active therapeutic agent encapsulated by the polymer shell.

Abstract: The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps: (A): a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A); wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal Layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.

Abstract: The present disclosure provides devices for treating breasts. The devices (100) include a sheet of acellular tissue matrix having a predefined shape that allows for complete or enhanced coverage of an anterior portion of a breast implant or tissue expander or to support an implant and/or surrounding tissues. The sheet includes curved upper and lower borders or edges.

Abstract: Provided are methods for preparing gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth scaffolds. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.

Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.

Abstract: The present invention provides a method for forming a connective tissue body, which enables extending the ranges of design values in terms of shape, dimension, etc., of the connective tissue body. This method comprises: a fat treatment step for removing fat contained in a connective tissue body, which is formed in an environment where a biological tissue material is present, from the interior of the connective tissue body while the connective tissue body is being set in a molding tool, and for causing the shape of the connective tissue body to follow the shape of the molding tool; and a bioinert solution treatment step for immersing the connective tissue body, together with the molding tool, in a bioinert solution while the connective tissue body is being shaped so as to follow the shape of the molding tool after the fat treatment step.

Abstract: A porous bionic skull repairing material includes a polymer material, whose structure is consistent with that of a human skull. The surface layers of the porous bionic skull repairing material are dense layers which are composed of non-degradable or degradable polymer materials and has blind holes having an asymmetric structure, and the inner layer of the porous bionic skull repairing material is a loose layer which has a porous structure. The repairing material can be molded by adopting a mixed mould pressing method or a 3D printing method, simulates a bone structure, with two dense sides and a loose middle, of a human skull to the greatest extent.

Abstract: Provided are a method for producing a cell tissue, including a culturing step of culturing cells capable of serving as a feeder inside opening pores and communicating pores of a porous film having a plurality of the opening pores provided on a surface thereof and the communicating pores communicating mutually adjacent opening pores with one another; and a porous film including a plurality of opening pores provided on a surface thereof and communicating pores communicating mutually adjacent opening pores with one another.

Abstract: Provided are porous, hydrogel, and multilayer tissue matrix scaffolds that are derived from native tissues. The scaffolds can be used for cell culture, preparing tumoroids for in vivo implant, and testing or screening the efficacies or toxicities of drugs toward cancers or other diseases.

Abstract: An iron-based biodegradable component includes an iron element of 60 to 99.5 parts by weight and modifying material of 0.5 to 40 parts by weight, wherein the modifying material includes at least one of a zinc element of 0.1 to 5 parts by weight and a biodegradable ceramic material of 0.1 to 40 parts by weight.

Abstract: A biodegradable cardiovascular implant is provided for growing cardiovascular tissue in a patient. The implant distinguishes an electro-spun network with supramolecular compounds having hard-blocks covalently bonded with soft-blocks resulting in much enhanced durability and fatigue resistance, while maintaining the effectiveness as a cardiovascular implant.

Abstract: Methods of varying the stiffness of polymeric medical tubes.

Abstract: The present disclosure provides a degradable corrosion-resistant high strength and ductility magnesium alloy for biomedical use and the preparation method therefor. With regard to a total weight of the magnesium alloy of 100%, the composition of components of the magnesium alloy comprises: 1.0 to 4.5% of Nd, 0.2 to 2.0% of Zn, 0 to 1.0% of Ca, 0 to 1.0% of Zr, and balance of Mg. The magnesium alloy is prepared by producing a magnesium alloy ingot by means of vacuum semi-continuous casting and according to the components and weight percentage thereof followed by solid solution treatment and extrusion. The degradable corrosion-resistant high strength and ductility magnesium alloy for biomedical use provided by the present disclosure has the advantages of being non-toxic and fully degradable, good corrosion resistance as well as high strength and ductility etc., and can be used for preparing a vascular stent.

Abstract: The present invention relates to an endoscopic treatment instrument. The endoscopic treatment instrument of the present invention includes a dual tube inserted into a channel of an endoscope, the dual tube including an outer tube and an inner tube being inserted into the outer tube and moving forward and backward relative to the outer tube, wherein since the outer tube of the dual tube is made of a plastic material having a silicone compound added to an organic polymer, when the inner tube moves forward and backward along the channel relative to the outer tube while the dual tube is bent, frictional resistance between an outer circumferential surface of the inner tube and an inner circumferential surface of the outer tube, is lower than frictional resistance therebetween when the outer tube and the inner tube of the dual tube are all made of an organic polymer alone.

Abstract: The invention provides devices and methods for aneurysm treatment using a material that minimizes susceptibility artifacts in MRA images. Since images are not obscured by susceptibility artifacts associated with the aneurysm treatment device, those images are useful and reliable for evaluating the success of treatment. The material is preferably a non-ferromagnetic metal alloy and may include one or a combination of cobalt, nickel, chromium, and molybdenum. In certain embodiments, the material is a 35Cobalt-35Nickel-20Chromium-10Molybdenum-Low Titanium alloy medical-grade material.

Abstract: Surgical systems can include evacuation systems for evacuating smoke, fluid, and/or particulates from a surgical site. A surgical evacuation system can be intelligent and may include one or more sensors for detecting one or more properties of the surgical system, evacuation system, surgical procedure, surgical site, and/or patient tissue, for example. Communication among devices in the surgical system may include a surgical evacuation system acquiring a value of a parameter and transmitting the value of the parameter to a cloud computing network or a surgical hub. The cloud computing network or surgical hub may process the value of the parameter, determine an impact of the value of the parameter on the surgical evacuation system or a modular device, and send an instruction to adjust operation to the surgical evacuation system or the modular device. The surgical evacuation system or the modular device will adjust operation based on the instruction.

Abstract: Surgical systems are disclosed. Surgical systems can include evacuation systems for evacuating smoke, fluid, and/or particulates from a surgical site. A surgical evacuation system can be intelligent and may include one or more sensors for detecting one or more properties of the surgical system, evacuation system, surgical procedure, surgical site, and/or patient tissue, for example.

Abstract: A system for managing reduced pressure to a wound site includes a wound enclosure configured to form a substantially sealed volume around the wound site, a first closed volume, a second closed volume, and a controller. The first closed volume includes a primary pressure source and a canister fluidly coupled to the primary pressure source. The first closed volume is configured to apply reduced pressure to the wound site and deliver exudate collected from the wound site to the canister through a first lumen. The second closed volume includes a secondary pressure source and is configured to apply a secondary pressure to the wound site through a second lumen to facilitate flow of the exudate from the wound site to the canister through the first lumen. The controller is configured to communicate with at least the second closed volume for selectively applying the secondary pressure to the wound site.

Abstract: Disclosed is a chest drainage system which reduces or eliminates pooling of blood/liquid and/or clogging/clotting in the drainage tube and/or chest tube, and provides objective and accurate measures of drained fluid volume and chest air leak. The chest drainage system continuously monitors chest tube and drainage tube status and clears pooled liquid in the drainage tube, and/or a clogged chest tube when necessary to restore negative pressure to the chest.

Abstract: A surgical evacuation system having dual in-series large and small droplet filters is provided. The surgical evacuation system comprises a pump, a motor operably coupled to the pump, and a flow path fluidically coupled to the pump. the flow path comprises a first fluid filter configured to extract a large droplet in a fluid moving through the flow path and a second fluid filter configured to extract a small droplet in the fluid moving through the flow path. the first fluid filter is coupled in series with the second fluid filter. The first fluid filter is positioned upstream of the second fluid filter. An outlet port of the second fluid filter is coupled to an inlet port of a non-fluid filter.

Abstract: A device for aspirating body fluids and for supplying a substance to a human or animal body is defined. The device comprises a first pump (8) for the aspiration of the body fluids, and a second pump (3), or a coupling element (76?) for connecting a second pump (3?) in order to convey the substance to the body by means of the second pump (3, 3?). Moreover, the device comprises a drive (70, 70?) for driving the first pump (8). The same drive (70, 70?) which serves to drive the first pump (8) also serves to drive the second pump (3, 3?).

Abstract: The present invention relates to a negative pressure wound therapy device, system and method. The negative pressure wound therapy device is connected with a dressing, and comprises a housing, a control circuit board, a pump, and an aspiration conduit. The pump generates negative pressure. The pump may comprise a voltage-actuated deformation element (such as piezoelectric vibration element) to push fluid from an aspiration end to a discharge end. The aspiration conduit has a pump end and a dressing end. The pump end is fluidly connected to the aspiration end of the pump, and the dressing end is fluidly connected to the dressing used for covering a wound. The control circuit board is disposed in the housing, controls the pump to generate the negative pressure in the aspiration conduit, and applies negative pressure to the wound covered by the dressing via the aspiration conduit.

Abstract: A fluid treatment system for a percutaneous cable and methods of assembly and use are described herein. In one aspect, the fluid treatment system includes a delivery tube comprising a distal end and a proximal end. The distal end is configured to surround at least a portion of a percutaneous cable. The percutaneous cable extends from within a patient to outside the patient through tissue at an exit site. The proximal end is connectable to a fluid source. Fluid from the fluid source is configured to be delivered to the exit site through the delivery tube. The fluid treatment system includes an anchor coupleable to the percutaneous cable to secure the percutaneous cable to the tissue at the exit site.

Abstract: A cannula system for providing a fluid connection to a heart includes a cannula having an end configured for connection to a myocardium of a heart. The cannula defines an inlet and includes a first cuff extending around the cannula so as to cover a substantial portion of an exterior surface of the cannula proximate the inlet. Additionally, a second cuff may be included that extends around the first end of the cannula adjacent a distal end of the first cuff.

Abstract: Circulatory assistance device for a heart of a living being, including a cuff for periodically applying pressure to the heart by at least one dielectric elastomer membrane which is controllable by a control device in synchronization with a cardiac beat in order to convey blood in pulses, wherein the cuff is designed to be pulled over the outside of the heart and for this purpose has an inner shape that is adapted to the outer contour of the heart at least in the region outside the ventricles, wherein the cuff is composed of an outer contraction layer including the dielectric elastomer membrane and an inner padding layer, and the padding layer is filled with an incompressible liquid and has at least one outlet valve, which is closed in a normal state and opened in an emergency state.

Abstract: A blood pump comprises a pump casing having a blood flow inlet and outlet, and an impeller arranged in said pump casing so as to be rotatable. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump comprises an outflow cannula having an upstream end portion, a downstream end portion and an intermediate portion. The upstream end portion is connected to the pump casing such that blood is conveyed from the blood flow outlet through the intermediate portion towards the downstream end portion. The downstream end portion has a blood flow outlet through which blood can exit the outflow cannula. At least a portion of the intermediate portion of the outflow cannula has an outer diameter that is larger than an outer diameter of the pump casing.

Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a filtration unit (2), a blood withdrawal line (6), a blood return line (7), an effluent fluid line (13), a pre and/or post-dilution fluid line (15, 25) connected to the blood withdrawal line, and a dialysis fluid line. Pumps (17, 18, 21, 22, 27) act on the fluid lines for regulating the flow of fluid. A control unit (10) is configured to periodically calculate a new value for the patient fluid removal rate to be imposed on an ultrafiltration actuator in order to keep a predefined patient fluid removal rate across a reference time interval irrespective of machine down times.

Abstract: A renal failure therapy system (10a, 10b) includes a dialysis fluid circuit (30) including a dialysis fluid pump (54, 58); a source (86, 90) of physiological cleaning, disinfecting, and/or decalcifying substance in fluid communication with the dialysis fluid circuit; a source (22) of purified water in fluid communication with the dialysis fluid circuit; and a logic implementer (20) in operable communication with the dialysis fluid pump (54,58), the logic implementer (20) causing the physiological cleaning, disinfecting, and/or decalcifying substance from its source (86, 90) to be added to purified water from the purified water source (22) to form a mixture and to circulate the mixture within the dialysis fluid circuit using the dialysis fluid pump (54,58) to at least one of clean, disinfect or decalcify at least a portion of the dialysis fluid circuit (30) without a subsequent rinse.

Abstract: An apparatus peritoneal dialysis (1) comprising an automated peritoneal dialysis cycler (3) programmed to run a treatment session including a plurality of cycles, each cycle including a fill phase, a dwell phase and a drain phase of a peritoneal cavity of a patient (P), the treatment session lasting at most 720 min; the cycler (3) has a patient line (54) in communication with the patient (P), a source (S) of treatment fluid which includes an osmotic agent, a pump (5) to circulate the treatment fluid and a control system (74) configured to drive the cycler (3) to deliver the treatment session.

Abstract: Systems and methods are provided for improved techniques associated with administering peritoneal dialysis. Embodiments of the invention relate to the continuous introduction and circulation of dialysate fluid in and through the peritoneal cavity. This constant influx of fresh fluid results in a perpetually high diffusion gradient between the toxin solute concentration of the blood and the dialysate fluid traversing the abdominal cavity, which promotes a much more efficient and rapid transfer of toxic solutes from the blood stream into the abdominal fluid. The fluid is continuously removed from the abdominal cavity and passed through an external filter using a pulsatile pump. The external filter cleanses the toxic solutes from the fluid before returning the fluid to the abdominal cavity. Embodiments of the invention also relate to improvements in catheters used to access the peritoneal cavity.

Abstract: A blood purification apparatus that is capable of, with no preparatory operations, performing substitution by supplying dialysate in a dialysate introduction line to a blood circuit during ultrafiltration treatment, or performing blood return by immediately supplying the dialysate in the dialysate introduction line to the blood circuit after the ultrafiltration treatment. A blood purification apparatus includes a dialyzer, a dialysate introduction line, a dialysate drain line L2 through which drain liquid from the dialyzer is drained, and an ultrafiltration pump capable of removing water from the blood in the blood circuit. The blood purification apparatus is capable of performing substitution or blood return by supplying the dialysate in the dialysate introduction line L1 to the blood circuit.