Abstract: The present disclosure describes for at least two zones of selective thermal therapy of the body. Three-port extracorporeal circuits are described that can be used to establish at least two zones of selective thermal therapy of the body. The example three-port extracorporeal circuit includes a branching section that provides for setting the temperature of blood injected into two different portions of the body at differing temperature levels, to provide. at least two zones of selective thermal therapy.

Abstract: An apparatus for reducing pathogens in blood. An infusing blood source provides a supply of blood at a selectable flowrate. A blood transportation line transports the blood from the infusion blood source. A UV-passing cuvette receives the blood from the blood transportation line. An irradiation chamber has a clamp for fixing the UV-passing cuvette at a predetermined gap from the UV radiation source for exposing the blood within the UV-passing cuvette directly to UV radiation. A radiation recycling coating is formed on surfaces of the irradiation chamber for reflecting and recycling the UV radiation to expose the blood indirectly to the UV radiation. The predetermined gap and the flow rate are selected so that the direct and indirect exposure of the blood to the UV radiation kills pathogens in the blood while limiting the loss of healthy blood cells and blood constituents due to the UV radiation and heat generated by the UV radiation source.

Abstract: The present application relates to an intermediate structure for a support structure of a medicament delivery device, which support structure is to cooperate with a medicament container, said support structure comprising a flexible element arranged to exert a force on a distal end surface of said medicament container, wherein said intermediate structure is arranged between said flexible element and said end surface and arranged to guide said flexible element in an outwardly direction in relation to a longitudinal axis (L) when exerting a force on said medicament container.

Abstract: This invention relates to an injection device for delivering a medicament to the human or animal body, in particular, but not exclusively, to a device having a replaceable medicament cartridge, including an auto-injector, wherein the injector device comprises: a housing; a piston rod for driving a bung of a medicament container; a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament; and control means for controlling operation of the device.

Abstract: An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

Abstract: The present invention is a device of a micro bubble pump utilizing a pulsating bubble as the actuator and corresponding method for using the micro bubble pump for transporting liquid. The main body of the device comprises a narrow tube with two liquid columns separated by a gas bubble. Separate reservoirs containing respective fluids are connected to either of the liquid columns through small valve-controlled openings. External ultrasound waves imposed on the liquid columns oscillate the bubble, allowing it to shrink and expand and causing liquid to flow into and out of the tube respectively. In a preferred embodiment, the inlet and outlet valves are replaced with diffusers. The micro bubble pump has no moving parts and can be actuated by remote energy sources. These features together with compactness and biocompatibility make the micro bubble pump an ideal candidate for an implantable device for drug delivery and biomedical applications.

Abstract: The present invention relates to a medical instrument, and more particularly, to a balloon infuser. The balloon infuser includes an upper cover (10) in which a scale mark (13) including linear scales is displayed, a lower cover (20) fixed to a lower side of the upper cover (10), a flexible expandable member (70) located inside the upper cover (10) and in which contents are accommodated, and an elevation part (30) elevated according to an expansion degree of the expandable member (70) and having a scale indication line (34) on one surface thereof, the scale indication line (34) indicating the scale mark (13).

Abstract: An injection device for subcutaneous delivery of fluid which comprises a puncture cannula and an indwelling cannula. In a starting position, a distal end region of the puncture cannula runs coaxially inside the indwelling cannula. The device comprises displaceably mounted first and second runners. The first runner is connected to the puncture cannula and the second runner to the indwelling cannula. A control element is movable over a predefined control area. The control element is configured such that, in a first part of the control area, the control element effects an equidirectional displacement of the first and the second runners, and hence fitting of the indwelling cannula and, in a second part of the control area, effects blocking of the second runner, and hence holding of the indwelling cannula in a dwell position, and return of the first runner and withdrawal of the puncture cannula into an end position.

Abstract: A device (1) for dispensing a fluid, in particular under aseptic conditions, preferably to a patient. The device comprises a conveying device (2) for conveying the fluid to a dispensing opening (3). The device (1) also comprises a coupling element (4) for coupling a syringe (5). The fluid can be conveyed from the syringe (5) to the dispensing opening (3) via the coupling element (4) and the conveying device (2) exclusively by the effect of the conveying device (2). The invention further relates to a system for dispensing a fluid under aseptic conditions, comprising such a device (1) and to a syringe (5) that can be coupled to the coupling element (4).

Abstract: A powerhead (50) of a power injector is disclosed that includes a syringe housing (110) that contains a capacitive fluid detector (112). The capacitive fluid detector (112) may be operable to detect fluid within a syringe (116) installed on the syringe housing (110). The output of the capacitive fluid detector (112) may be used to estimate the volume of fluid within the syringe (116). The capacitive fluid detector (112) may include a plurality of discrete capacitors (118a-118h) arranged serially along a longitudinal axis (120) of the syringe (116). Each of the plurality of capacitors (118a-118h) may be operable to produce an electric field extending into the syringe (116). Each of the plurality of capacitors (118a-118h) may be formed on a printed circuit board (130).

Abstract: Provided is a system and method for a high flow at low pressure infusion system needle set for delivering a liquid from a reservoir to a patient. More specifically, provided is a high flow at low pressure infusion system needle set including a flexible tubing element having a first length and a first end structured and arranged to connect to the reservoir, and a second end opposite thereto, the flexible tubing element having a first internal diameter. A needle having a second length and a second internal diameter is coupled to the second end of the flexible tubing, the needle having a first portion providing a sharpened distal end for penetration of the patient's tissue and a second portion providing a second end in fluid communication with the second end of the flexible tubing element, the first portion and second portion generally normal to each other.

Abstract: A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device involves obtaining one or more measurement values of a physiological condition in the body of a user during an initial monitoring period and determining a fasting reference value for a metric based on the one or more measurement values. After the initial monitoring period, the method continues by obtaining an updated measurement value during a fasting period, determining a current value for the metric based at least in part on the updated measurement value, and generating a notification in response to a deviation between the current value and the fasting reference value exceeding a threshold indicative of insertion site loss or other loss of effectiveness.

Abstract: Sensors are attached to a living being so as to generate corresponding sensor signals. A monitor is in communications with the sensors so as to derive physiological parameters responsive to the sensor signals. Predetermined limits are applied to the physiological parameters. At least one indicator responsive to the physiological parameters and the predetermined limits signal the onset of a sepsis condition in the living being.

Abstract: A device (1) and the use thereof for dispensing fluid under aseptic conditions. The device (1) comprises conveying device (2) and container (3) with a variable inner volume. The conveying device comprises cylinder (4) with at least three openings (5, 6, 7) which are arranged along longitudinal central axis (11). Displaceable first and second pistons (9, 10) are arranged in the cylinder. The end faces (11, 12) of the pistons and inner wall (13) of the cylinder, delimit a variable fluid volume (14). The first opening is brought into fluidic communication with dispensing opening (15) and the second opening is brought into fluidic communication with the container. Each of the pistons comprise three seals (16, 16?, 16?) which are offset and sealingly close off the cylinder. Adjacent piston seals have inner spacing (di) which is equal to a shortest spacing (aA1) between two adjacent openings (5, 6 or 6, 7).

Abstract: A drug delivery device includes a housing, a cartridge received within the housing, with the cartridge configured to receive a medicament, a drive assembly received within the housing and configured to engage the cartridge and dispense medicament from the cartridge, and a needle actuator assembly received within the housing, with the needle actuator assembly including a patient needle configured to pierce a patient's skin. A bottom surface of the housing defines a port interface configured to receive an implanted injection port.

Abstract: A priming assembly for a drug delivery device includes a hub, a base connected to the hub and moveable relative to the hub between a first position and a second position, with the base defining a passageway, a cap defining an interior chamber and a passageway in fluid communication with the interior chamber, and a needle connected to the hub and positioned within the interior chamber of the cap, where the passageway of the base is in fluid communication with the passageway of the cap when the base is in the first position, and where the passageway of the base is isolated from the passageway of the cap when the base is in the second position.

Abstract: In one aspect the present disclosure refers to a supplementary device for an injection device, the supplementary device comprising: a body attachable to a housing of the injection device, the body having a first portion facing towards the housing when attached to the housing, at least one light source attached to the body, and at least a first optical coupling located in or at the first portion, connected to the at least one light source in a light transmissive way and optically connectable to a second optical coupling arranged in or on the housing.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.

Abstract: A needle assembly for a hypodermic syringe is disclosed herein. In various aspects, the needle assembly includes a hub and a needle. A bond secures the needle to the hub, and the bond is configured to break allowing the needle to be withdrawn entirely from the hub upon application of a selected axial force to the needle, in various aspects. The axial force may be less than the tensile strength of the needle. Related methods of use of the needle assembly apparatus are disclosed herein. This Abstract is presented to meet requirements of 37 C.F.R. § 1.72(b) only. This Abstract is not intended to identify key elements of the apparatus and the related methods disclosed herein or to delineate the scope thereof.

Abstract: An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement.

Abstract: The present disclosure relates to a sheath remover for removing a protective needle sheath from a drug cartridge. The sheath remover includes a resilient ring and one or more resilient legs attached to the ring and extending in a proximal direction. Each leg includes an inwardly directed ledge arranged at a proximal end of the leg. The ring consists of a resilient material allowing inward deflection of a proximal end of the ring. The present disclosure further relates to a method for assembling and a method for using the sheath remover.

Abstract: An apparatus for removing a needle shield from a syringe may be configured to receive the removable needle shield. The remover may include a body and a deflectable arm. The deflectable arm may include a distal end coupled to the body and a proximate end distal a proximate end of the body. The deflectable arm may be configured to engage and apply a force to the needle shield when the cap is detached from the syringe, thereby removing the needle shield from the syringe.

Abstract: Skin can be treated by piercing skin with a plurality of needles of an injection device and ejecting a dose of fluid therethrough. The device can include a housing, a plunger disposed in the housing, a cartridge disposed in the housing, and one or more dosing chambers. The plurality of needles can be coupled to the housing and be in fluid communication with the cartridge. Advancement of the plunger can cause a dose of fluid to be ejected from the plurality of needles.

Abstract: An example medical device includes a body portion having a tubular inner wall defining an inner channel, and a tubular outer wall encircling the inner wall. The outer wall defines an outer channel between the outer wall and the inner wall. The body portion also includes an indicator substance disposed within the outer channel. The device also includes an indicator portion defining an indicator channel. The body portion is configured to insert at least in part into a patient, and the indicator portion is configured to remain at least in part along an exterior of the patient when the body portion is inserted into the patient. The device is also configured to transfer at least a portion of the indicator substance from the outer channel to the indicator channel when the body portion is bent.

Abstract: An example medical device includes a body portion having a tubular inner wall defining an inner channel, and a tubular outer wall encircling the inner wall. The outer wall defines an outer channel between the outer wall and the inner wall. The body portion also includes an indicator substance disposed within the outer channel. The device also includes an indicator portion defining an indicator channel. The body portion is configured to insert at least in part into a patient, and the indicator portion is configured to remain at least in part along an exterior of the patient when the body portion is inserted into the patient. The device is also configured to transfer at least a portion of the indicator substance from the outer channel to the indicator channel when the body portion is bent.

Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

Abstract: A liquid dispenser for discharging cosmetic or pharmaceutical liquids, in particular in the form of an inhaler. This liquid dispenser includes a switchable valve mechanism, a base, and a discharge head which, for actuation of the valve mechanism, is movable with respect to the base in a superposed axial and rotational movement or in a rotational movement between an opening position, in which the valve mechanism is opened, and a closure position, in which the valve mechanism is closed. It is proposed that, in a delivery state of the liquid dispenser, a rotational movement of the discharge head with respect to the base is blocked by a tamper-evident portion that is separable from the dispenser.

Abstract: A device for dispensing an air-dischargeable substance includes an air inlet, a substance-loaded air discharge nozzle, an outflow region having a chamber containing the substance, a first air guide duct from the outflow region to the nozzle, and a second air guide duct from the inlet to the outflow region fluidically connected, via a connection channel, to the first air guide duct. Air flows in through an inflow opening through the connection channel into the first air guide duct perpendicularly to the substance-loaded air flow direction into the first air guide duct in the inflow-opening region. The outflow region has a partition of hard material between the first and second air guide ducts with a soft material free end face facing the chamber. The chamber includes a foil cover overlapping with a chamber cavity containing the substance against which the partition lies forming a seal via the soft material.

Abstract: A handheld device for dispensing a pharmaceutical substance has a housing in which a storage container with the pharmaceutical substance and a counter are arranged. The storage container dispenses the pharmaceutical substance by pressure actuation by a user after a specified displacement path has been traversed, and the counter carries out an action in order to rotate a counter wheel of the counter on the basis of the displacement path being traversed. The counter additionally has a drive part rotates the counter wheel, and the counter wheel is rotatably attached to a mounting part. The mounting part is formed independently of the housing, and the drive part is directly attached to the mounting part. The handheld device advantageously dispenses a pharmaceutical substance in that the action is first carried out on the counter wheel of the counter upon the pressure actuation, and the pharmaceutical substance is then dispensed.

Abstract: Provided is a hydrogen gas aspirator which can be carried by a user and freely carried by the user, and which can be supplied with hydrogen gas by adjusting concentrations of the aspirator. The hydrogen gas aspirator for generating and aspirating hydrogen gas includes: a first hydrogen gas aspirator body having at least a hollow interior; a second hydrogen gas aspirator body having an aspirator hollow layer and an aspirator hollow layer connected to each other by a low pressure check valve; and a variable pressure control valve capable of adjusting and passing hydrogen gas concentrations between the first and second hydrogen gas aspirator bodies, wherein substances that hydrogen generate and react by contacting water and water for reaction can be placed on the aspirator hollow layer inside the second hydrogen gas aspirator body.

Abstract: An arrangement for powering a pump in providing a controlled volume of water to a drip nozzle in a drip-feed humidifier. The pump arrangement including: a pump having a solenoid; a processing unit; and a power supply electrically connected to the solenoid via a switch which is controlled by the processing unit. The power supply is structured to supply power to the solenoid via the switch. The processing unit is programmed to modulate the power to the solenoid such that the pump is driven at or near a resonant frequency of the pump.

Abstract: The present disclosure relates to a capnotracking method for continuous determination of cardiac output or EPBF of a mechanically ventilated subject (3), comprising the steps of measuring (S1) expiratory CO2 of the subject and determining (S2) a first value of cardiac output or EPBF of the subject at a first point in time. The method further comprises the steps of controlling (S3) the mechanical ventilation of the subject to keep a level of venous CO2 of the subject substantially constant between the first point in time and a second point in time, determining (S4) from the expiratory CO2 measurements a change in alveolar CO2 of the subject between the first and second points in time, and determining (S5) a second and updated value of cardiac output or EPBF of the subject based on the first value and the change in alveolar CO2 .

Abstract: An artificial airway assembly for ventilating a patient, is provided, comprising a flexible airway tube having a proximal end and a distal end, adapted to guide a working tool to an operating position to view vocal cords and trachea of the patient, said flexible airway tube comprising at least one locally weakened and tearable course adapted to permit detachment of at least a section of said airway tube while maintaining said working tool in said operating position; and a mask fixedly secured to said distal end of said flexible airway tube, said mask having conforming means for conforming to a space immediately adjacent to the larynx of the patient to properly position said working tool. In alternative embodiments, the assembly further includes an inflatable balloon that directs the airway tube toward the patient's trachea.

Abstract: A pressurized air delivery device, system and method provide respiratory assistance to individuals, particularly infant humans. The device having nasal conduits or prongs which are in fluid communication with respective supply conduits separately supply each nasal conduit with a breathable gas such as air or oxygen. The size of the nasal conduits or prongs may be chosen according to the size of the individual's nares and the spacing between nasal conduits or prongs may be adjustable.

Abstract: The present disclosure pertains to a nasal therapy system. In one embodiment, the nasal therapy system includes at least one flow sensor is configured to determine a flow rate of a gas flow to be provided to a patient via a nasal interface; at least one pressure sensor configured to determine an amount of pressure of the gas flow based, at least in part, on a prescribed pressure; a valve operable to control an amount of the gas flow being provided to the nasal interface; and a controller configured to determine a flow rate difference between a prescribed flow rate and the flow rate, and cause an output setting of the valve to be adjusted to control the amount of the gas flow being provided to the nasal interface such that the amount of the gas flow is maintained at the prescribed flow rate and the prescribed pressure.

Abstract: The invention involves masks and systems for providing respiratory treatments to various large animals including horses, mules, ponies and cattle. The masks are easy to clean for reuse and low in cost due to simple designs, a very low thickness requiring less material and the systems include the masks of the invention.

Abstract: A conduit for a breathing circuit includes a heater associated, at least in part, with a hydrophilic layer. The purpose of the heater is to evaporate any condensed liquid collecting in the conduit, which is first sucked up by the hydrophilic layer. The heated wick reduces the risk of collected water being passed to the patient and causing choking fits or discomfit. It is preferred that the heated wick lies freely in the conduit to settle at low points in the conduit where condensation may collect.

Abstract: A humidifier is for an airway pressure support system for delivering a humidified flow of breathing gas to an airway of a patient. The humidifier includes a water chamber, a filter, a filtration meter, a conduit, a nozzle, and a heater plate. The filter has a housing structured to house a filtration medium therein and having an inlet fluidly connected with the water chamber and an outlet. The filtration meter includes an inlet fluidly connected to the outlet of the filter, an outlet, a body portion extending between the inlet and the outlet which is structured to convey water from the inlet of the filtration meter to the outlet of the filtration meter, and a mechanism located in the body portion which is structured to measure filtration data of the water conveyed through the body portion.

Abstract: A method for operating a humidifier coupled to a gas flow generator. The humidifier has a pump providing a supply of water to a heater plate. The method includes: providing power to the gas flow generator; raising the temperature of the heater plate from an ambient temperature to about a first predetermined temperature; powering the pump at about a predetermined first duty cycle; monitoring the temperature of the heater plate until one of: a drop in temperature is detected, or a predetermined period of time has elapsed; and one of: increasing the duty cycle of the pump if the drop in temperature is detected, or turning off the pump if the predetermined period of time has elapsed.

Abstract: A humidifier is for an airway pressure support system for delivering a humidified flow of breathing gas to an airway of a patient. The humidifier includes a water chamber, a conduit, a nozzle, a heater plate, and a number of heating elements. The nozzle is fluidly connected to the water chamber and has an outlet configured to produce a water droplet from water received from the water chamber. The heater plate is coupled to a wall portion of the conduit and is exposed to an interior pathway of the conduit. The heater plate has a first side facing the nozzle and an opposite second side facing away from the nozzle. The first side is positioned to receive the water droplet from the nozzle. The number of heating elements are coupled to the second side of the heater plate.

Abstract: A humidifier is for an airway pressure support system for delivering a humidified flow of breathing gas to a patient. The humidifier includes a water chamber, a conduit, a nozzle, a heater plate, and a separator feature. The conduit includes first and second ends, and a wall portion defining an interior pathway between the first and second ends and structured to convey the flow of breathing gas between the first and second ends. The nozzle is fluidly connected to the water chamber and configured to produce a water droplet from water received from the water chamber. The heater plate is coupled to the wall portion, exposed to the interior pathway, and positioned to receive the water droplet from the nozzle. The separator feature is coupled to the wall portion and configured to shield the water droplet from the flow of breathing gas.

Abstract: A pump arrangement for powering a pump in providing a controlled volume of water to a drip nozzle in a drip-feed humidifier. The pump arrangement includes: a pump having a solenoid; a processing unit; and a power supply electrically connected to the solenoid via a switch which is controlled by the processing unit. The power supply is structured to supply power to the solenoid via the switch. The processing unit is programmed to modulate the power provided to the solenoid via the switch such that the power is supplied to the solenoid according to a power profile for each actuation of the solenoid. The power profile includes: an initial portion which increases at a first overall rate, an intermediate portion which increases at a second overall rate different than the first overall rate, and a final portion which decreases at a third overall rate.

Abstract: A sedation device has a housing divided internally into a ventilator chamber and an associated evaporator chamber which overlap and are separated by a filter mounted between the chambers and forming a common gas-permeable dividing wall between the chambers. An inlet port is provided at one end of the ventilator chamber at a top of the housing for connection to a patient ventilator in use. An outlet port on the evaporator chamber can be connected via a breathing tube to a patient. An evaporator is mounted within the evaporator chamber for delivery of a volatile sedative into the evaporator chamber during use.

Abstract: Liquid accumulators and methods for reducing pulsations of a liquid flow are disclosed. A liquid delivery system comprises a pump configured to drive liquid to a pipe. The pipe is configured to transmit a liquid flow. A liquid accumulator is fluidically connected to the pipe. The liquid accumulator comprises a chamber containing the liquid and a vapor column and a power source configured to input energy to the chamber to generate vapor from the liquid to form the vapor column. The vapor column constitutes a gas spring to reduce pulsations of the liquid flow in the pipe. The spring rate of the gas spring can be adjusted by changing the input energy level from the power source to the chamber.

Abstract: A device for stimulation of a patient with acoustic stimulation signals includes a stimulation unit for generating acoustic stimulation signals and a control unit for controlling the stimulation unit. The control unit is configured so that it determines a bandwidth of an auditory filter with a frequency of a predetermined tone as a center frequency, wherein this bandwidth is a reference bandwidth. The control unit determines a frequency of a first acoustic therapy signal such that a measure of coverage between the reference bandwidth around the frequency of the predetermined tone and a first bandwidth of an auditory filter with the frequency of the first acoustic therapy signal as a center frequency assumes a predetermined first value, and controls the stimulation unit such that the stimulation unit generates the first acoustic therapy signal.

Abstract: A method for producing or modifying an audio composition to promote sleep and improve the quality of sleep. The invention provides a way to select for audio components which, when combined with modulated audio components, create an audio composition which has low salience and adequate variance to not just mask noise, but to encourage sleep without requiring repetitive, disruptive, or harmful audio elements.

Abstract: A catheter assembly is disclosed, comprising a catheter, such as a urinary catheter, which at least a partly is provided with hydrophilic coating. The catheter assembly further comprises a wetting fluid. The receptacle is in direct contact with the hydrophilic coating of the catheter over the part of the catheter with the hydrophilic coating. This may, for example, be achieved by using a shrink wrap material. In order to accomplish adequate wetting, channels or the like may be provided on the inner surface of the receptacle or the outer surface of the catheter.