Patents Issued in July 11, 2019
  • Publication number: 20190211394
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Application
    Filed: March 26, 2019
    Publication date: July 11, 2019
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Publication number: 20190211395
    Abstract: Embodiments of a method and/or system can include generating a set of quality control template (QCT) molecules; determining a set of QCT sequence read clusters based on the set of QCT molecules, such as based on variation regions of the set of QCT molecules; and based on the set of QCT sequence read clusters, determining a sequencing-related parameter, such as a contamination parameter and/or molecule count parameter, associated with the at least one of sequencing library preparation and sequencing.
    Type: Application
    Filed: August 6, 2018
    Publication date: July 11, 2019
    Inventors: David Tsao, Sukrit Silas, Oguzhan Atay
  • Publication number: 20190211396
    Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.
    Type: Application
    Filed: December 21, 2018
    Publication date: July 11, 2019
    Inventors: YUH-MIN CHIANG, Douglas B. Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
  • Publication number: 20190211397
    Abstract: Inhibitors of GPR132 are used in preventing and/or treating chemotherapy-induced neuropathic pain in a subject. The inhibitors can be included in a pharmaceutical composition. A method for identifying an inhibitor of GPR132 includes contacting a cell expressing GPR132 cultivated in the presence of an oxidized lipid with a compound suspected to be a GRP132 inhibitor, determining GPR132 activity, and comparing the determined GPR132 activity to GPR132 activity determined in a control cell.
    Type: Application
    Filed: September 22, 2017
    Publication date: July 11, 2019
    Inventors: Susanne SCHIFFMANN, Klaus SCHOLICH, Gerd GEISSLINGER, Stephan HOHMANN, Marco SISIGNANO
  • Publication number: 20190211398
    Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveneness to lupus therapeutic agents.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 11, 2019
    Applicant: Genentech, Inc.
    Inventors: Timothy W. BEHRENS, Robert R. GRAHAM
  • Publication number: 20190211399
    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
    Type: Application
    Filed: February 28, 2019
    Publication date: July 11, 2019
    Applicant: Natera, Inc.
    Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
  • Publication number: 20190211400
    Abstract: This invention provides methods of diagnosing or predicting susceptibility to Inflammatory Bowel Disease by determining the presence or absence of genetic variants in the TL1A gene. In one embodiment, a method of the invention is practiced by determining the presence or absence of TL1A production following Fc-gamma-R activation. In another embodiment, the invention provides methods of treatment of inflammatory bowel disease by inhibition of TL1A.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 11, 2019
    Inventors: Jerome I. Rotter, Kent D. Taylor, Marla Dubinsky, Stephan R. Targan
  • Publication number: 20190211401
    Abstract: A method for identifying a tumor that is susceptible to treatment with a TTK inhibitor, including: a) providing a sample of a tumor; b) determining the presence of a mutated CTNNB1 gene in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 gene indicates the tumor is susceptible to treatment with a TTK inhibitor. Alternatively, step b) is replaced by the step of determining the presence of a mutated CTNNB1 protein in the sample, wherein the mutation is located in exon 3 of CTNNB1 and the presence of a mutated CTNNB1 protein indicates the tumor is susceptible to treatment with a TTK inhibitor. In a further alternative, step b) includes determining an altered expression of a CTNNB1 regulated gene, whereby an altered expression of a CTNNB1 regulated gene indicates the tumor is susceptible to treatment with a TTK inhibitor.
    Type: Application
    Filed: April 14, 2016
    Publication date: July 11, 2019
    Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Jeroen DE ROOS, Joost Cornelis Marinus UITDEHAAG, Adrianus Petrus Antonius DE MAN, Rogier Christiaan BUIJSMAN, Guido Jenny Rudolf ZAMAN
  • Publication number: 20190211402
    Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
    Type: Application
    Filed: February 28, 2019
    Publication date: July 11, 2019
    Applicant: Natera, Inc.
    Inventors: Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
  • Publication number: 20190211403
    Abstract: The present invention relates to a method, in particular an in vitro method, for identifying CD8 positive subpopulations of a mammal, wherein said method comprises analyzing the bisulfite convertibility of at least one CpG position in the CD8 beta and CD8 alpha cell specific bisulfite convertibility gene region according to SEQ ID No. 1 and 2, wherein a bisulfite convertibility of at least one CpG position in said gene regions is indicative for a CD3+CD8+ and/or CD3+/?CD8+ cell. The analyses according to the invention can identify CD3+CD8+ and/or CD3+/?CD8+ cells on an epigenetic level and distinguish them from all other cells in complex samples, such as, for example, other blood cells.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 11, 2019
    Inventor: Sven OLEK
  • Publication number: 20190211404
    Abstract: Provided herein, among other things, are various compositions and methods for analyzing chromatin. In some embodiments, the composition may comprise a mixture of a nicking enzyme, four dNTPs, at least one labeled dNTP and, optionally, a polymerase. In some embodiments, this method may comprise: obtaining a sample comprising chromatin, reacting the sample with the composition to selectively label the open chromatin in the sample, and analyzing the labeled sample.
    Type: Application
    Filed: August 31, 2017
    Publication date: July 11, 2019
    Applicant: New England Biolabs, Inc.
    Inventors: Chaithanya Ponnaluri, Hang-Gyeong Chin, Pierre O. Esteve, Sriharsa Pradhan
  • Publication number: 20190211405
    Abstract: The present invention relates to methods, devices, combinations, kits, and systems for predicting and treating clinically significant prostate cancer in a urine sample of an individual suspected of suffering from prostate cancer based on expression analysis of normalised prostate tumour markers. The present methods, devices, combinations, kits, and systems are especially suitable for predicting and treating prostate cancer with a Gleason score of seven or more in individuals with a serum prostate-specific antigen (sPSA) level lower than 15 ng/ml.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 11, 2019
    Applicant: MDxHealth SA
    Inventors: Daphne Hessels, Franciscus Petrus Smit, Jack A. Schalken
  • Publication number: 20190211406
    Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
    Type: Application
    Filed: March 20, 2019
    Publication date: July 11, 2019
    Applicant: Natera, Inc.
    Inventors: Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
  • Publication number: 20190211407
    Abstract: Methods for detecting the presence or absence of the swine H1N1 influenza A virus, seasonal H1 influenza A virus and/or seasonal H3 influenza A virus nucleic acids in biological samples are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for amplifying in vitro the swine H1N1 influenza A virus, seasonal H1 influenza A virus and/or seasonal H3 influenza A virus nucleic acid and detecting amplified nucleic acid sequences are disclosed.
    Type: Application
    Filed: October 9, 2018
    Publication date: July 11, 2019
    Inventor: Ejan TYLER
  • Publication number: 20190211408
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: June 2, 2017
    Publication date: July 11, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • Publication number: 20190211409
    Abstract: A formed sandwich structure manufactured by a pressure-based forming method that includes steps of (1) positioning a sandwich structure into a cavity of a die assembly, the sandwich structure including a core positioned between a first liner sheet and a second liner sheet, the core including a honeycomb structure having a plurality of cells, and (2) after the positioning, pressurizing the core to expand the sandwich structure into engagement with the die assembly.
    Type: Application
    Filed: March 19, 2019
    Publication date: July 11, 2019
    Applicant: The Boeing Company
    Inventor: Thomas A. Dean
  • Publication number: 20190211410
    Abstract: The invention relates to a method for producing a steel material, particularly a corrosion-resistant steel material for pumps and similar, in which a steel corresponding to the following analysis (in wt. %) is smelted: C<0.050; Si<0.70; Mn<1.00; P<0.030; S<0.010; Cr=14-15.50; Mo=0.30-0.60; Ni=4.50-5.50; V<0.20; W<0.20; Cu=2.50-4.00; Co<0.30; Ti<0.05; Al<0.05; Nb<0.05; Ta<0.05; N<0.05.
    Type: Application
    Filed: May 11, 2017
    Publication date: July 11, 2019
    Inventors: Jochen PERKO, Michael Haspel, Patric SCHUTZ
  • Publication number: 20190211411
    Abstract: A method of manufacturing a welded structure of a ferritic heat-resistant steel is provided that prevents Type IV damage and that has good on-site operability without adding a high B concentration. The method includes: the step of preparing a base material including 1.0 to 7.0% Cr, less than 0.005% B and other elements; the step of forming an edge on the base material; a pre-weld heat treatment step in which a region located between a surface of the edge and a position distant from the surface of the edge by a pre-weld heat treatment depth of 10 to 50 mm is heated to a temperature of 950 to 1050° C. and is held at this temperature for 10 to 30 minutes; a welding step in which the edge is welded to form the weld metal; and a post-weld heat treatment step in which a region located between the surface of the edge and a position distant therefrom by a distance not smaller than the pre-weld heat treatment depth and not greater than 100 mm is heated to a temperature of 680 to 750° C.
    Type: Application
    Filed: September 29, 2017
    Publication date: July 11, 2019
    Applicant: Nippon Steel & Sumitomo Metal Corporation
    Inventors: Yasushi Hasegawa, Hirokazu Okada
  • Publication number: 20190211412
    Abstract: A hot-dip galvanized steel sheet includes a steel sheet and a hot-dip galvanized layer arranged on the steel sheet, in which the Si content and the Al content by mass % of components of the steel sheet satisfy a relationship 0.5<Si+Al<1.0, and a metallographic structure of the steel sheet satisfies a relationship of {(n2)2/3Ă—d2}/{(n1)2/3Ă—d1}Ă—ln(H2/H1)<0.3 when the n1 is the number of a MnS of a surface portion of the steel sheet, the d1 ?m is an average equivalent circle diameter of the MnS in the surface portion of the steel sheet, the H1 GPa is a hardness of a martensite of the surface portion of the steel sheet, the n2 is the number of the MnS of a center portion of the steel sheet, the d2 ?m is an average equivalent circle diameter of the MnS in the center portion of the steel sheet, and the H2 GPa is the hardness of the martensite of the center portion of the steel sheet.
    Type: Application
    Filed: March 18, 2019
    Publication date: July 11, 2019
    Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Toshiki NONAKA, Toshio OGAWA, Nobuhiro FUJITA
  • Publication number: 20190211413
    Abstract: Provided are a high-strength coated steel sheet and a method for manufacturing the same. The high-strength coated steel sheet has a base steel sheet and a coating layer formed on a surface of the base steel sheet. The base steel sheet has a specified chemical composition and a microstructure, including a martensite phase and a ferrite phase. A volume fraction of the martensite phase is 50% to 80%. A volume fraction of tempered martensite with respect to the whole martensite phase is 50% or more and 85% or less. An average grain diameter of the ferrite phase is 13 ?m or less. A volume fraction of ferrite grains having an aspect ratio of 2.0 or less with respect to the whole ferrite phase is 70% or more. Yield strength (YP) of the high-strength coated steel sheet is 550 MPa or more.
    Type: Application
    Filed: September 28, 2017
    Publication date: July 11, 2019
    Applicant: JFE Steel Corporation
    Inventors: Lingling Yang, Noriaki Kohsaka, Tatsuya Nakagaito, Yoshimasa Funakawa
  • Publication number: 20190211414
    Abstract: A steel pipe or tube for pressure vessels having excellent quench crack resistance is provided. The steel pipe or tube for pressure vessels comprises: a specific chemical composition; and a metallic microstructure in which an average grain size of prior austenite grains is 500 ?m or less, and an area fraction of microstructures other than ferrite is 50% or more.
    Type: Application
    Filed: August 8, 2017
    Publication date: July 11, 2019
    Applicant: JFE STEEL CORPORATION
    Inventors: Hiroshi OKANO, Shusaku TAKAGI
  • Publication number: 20190211415
    Abstract: Niobium chromium low allow carbon steel for automotive chain link plates has improved wear resistance. In one preferred embodiment, the steel composition includes niobium, chromium, carbon, iron, and any impurities. One preferred composition including these components includes, by weight percentage, approximately 0.25% to 0.75% carbon, approximately 0.20% to 2.0% chromium, approximately 0.26% to 1.5% niobium, and the remaining component of the composition is iron. Trace amounts of impurities may also be present. In another embodiment, a steel composition includes, by weight percentage, approximately 0.25% to 0.75% carbon, approximately 0.2% to 1.0% manganese, approximately 0.05% to 0.60% silicon, approximately 0.26% to 1.5% niobium, approximately 0.20% to 2.0% chromium, up to approximately 0.30% aluminum, up to approximately 0.03% phosphorus, up to approximately 0.03% sulfur, and a remainder of the composition being iron and any other impurities.
    Type: Application
    Filed: April 28, 2017
    Publication date: July 11, 2019
    Inventors: Yumin WANG, Matthew E. JUNKER
  • Publication number: 20190211416
    Abstract: Provided herein is a dual-phase stainless steel having excellent carbon dioxide corrosion resistance, excellent sulfide stress corrosion cracking resistance, and excellent sulfide stress cracking resistance. The dual-phase stainless steel contains, in mass %, C: 0.03% or less, Si: 1.0% or less, Mn: 0.10 to 1.5%, P: 0.030% or less, S: 0.005% or less, Cr: 20.0 to 30.0%, Ni: 5.0 to 10.0%, Mo: 2.0 to 5.0%, Cu: 2.0 to 6.0%, N: less than 0.07%, and the balance Fe and unavoidable impurities, and has a structure that is 20 to 70% austenite phase, and 30 to 80% ferrite phase in terms of a volume fraction.
    Type: Application
    Filed: August 22, 2017
    Publication date: July 11, 2019
    Applicant: JFE Steel Corporation
    Inventors: Yusuke Yoshimura, Hiroki Ota, Masao Yuga, Yuichi Kamo, Kenichiro Eguchi
  • Publication number: 20190211417
    Abstract: The invention relates to a method for producing a component from a medium manganese flat steel product having 4 to less than 10 wt. % Mn, 0.0005 to 0.9 wt. % C, 0.02 to 10 wt. % Al, the remainder iron, including unavoidable steel-accompanying elements, and having a TRIP effect at room temperature. In order to produce a component, which is distinguished by very high strengths and an increased residual strain and re-shaping capacity, the flat steel product, according to the invention, is re-shaped by at least one re-shaping step to form a component and, before and/or during and/or after the at least one re-shaping step, the flat steel product is cooled down to a temperature of the flat steel product of less than room temperature to ?196° C. The invention further relates to a component produced by this method and to a use for said components.
    Type: Application
    Filed: August 16, 2017
    Publication date: July 11, 2019
    Applicant: Salzgitter Flachstahl GmbH
    Inventors: PETER PALZER, THOMAS EVERTZ, MANUEL OTTO, KAI KĂ–HLER
  • Publication number: 20190211418
    Abstract: Provided is a blade material having high strength. The blade material contains, in % by mass, 0.5 to 0.8% of C, 1.0% or less of Si, 1.0% or less of Mn, 11 to 15% of Cr, and 0.1 to 0.8% of V, the remainder includes Fe and inevitable impurities, and has a thickness of 0.5 mm or less, wherein the structure of the blade material as observed after polishing the surface thereof has ferrites and carbides, the carbides have an average particle diameter of 0.5 ?m or less, and a proportion of carbides containing V in the carbides is 50% or less in terms of a proportion in an area of a field of view.
    Type: Application
    Filed: September 6, 2017
    Publication date: July 11, 2019
    Applicant: Hitachi Metals, Ltd.
    Inventor: Kazuhiro YAMAMURA
  • Publication number: 20190211419
    Abstract: A method and apparatus to reclaim metals from scrap material such as automobile shredder residue (ASR) that, after separating out light density components, separates out friable material such as rock and glass by crushing and screening operations to generate a high metal content product.
    Type: Application
    Filed: March 13, 2019
    Publication date: July 11, 2019
    Inventor: Timothy F. Conway
  • Publication number: 20190211420
    Abstract: Hydrometallurgical systems, methods, and compositions are described in which organic amine-based lixiviants are utilized in the selective removal of carbonate-forming alkaline earth elements from slag. The resulting processed slag has a reduced tendency to form carbonate salts on environmental exposure, and reduced tendency to fracture due to the formation of such salts. The lixiviant used can be regenerated and recycled for use in subsequent iterations of the process.
    Type: Application
    Filed: March 19, 2019
    Publication date: July 11, 2019
    Inventors: Zachary J.A. Zomon, Michael D. Wyrsta
  • Publication number: 20190211421
    Abstract: A method for recovering at least one precious metal from an aqueous solution containing the metal and particularly to recovery of silver and optionally one or more other precious metals from overflow of a sedimentation unit such as a thickener, a clarifier or a pond includes subjecting the aqueous solution to a micro and/or nanobubble flotation, wherein the pH of the aqueous solution is at most 1.5.
    Type: Application
    Filed: March 13, 2019
    Publication date: July 11, 2019
    Inventors: Kaj JANSSON, Mikko RUONALA, Tuukka KOTIRANTA
  • Publication number: 20190211422
    Abstract: The present invention relates to novel composite materials enriched with silicon dispersed in matrices comprising Ni, Ti and Si and/or Sn, optionally passivated, the method for producing said materials and to the use of same as electrodes. The invention further relates to the aforementioned matrices and the synthesis thereof.
    Type: Application
    Filed: May 18, 2017
    Publication date: July 11, 2019
    Applicants: Centre National D'Etudes Spatiales, SAFT, Centre National de la recherche scientifique, Université de Montpellier
    Inventors: Christian JORDY, Florent FISCHER, Fermin CUEVAS, Alix LADAM, Laurent ALDON, Pierre-Emmanuel LIPPENS, Nicolas BIBENT, Josette OLIVER-FOURCADE, Jean-Claude JUMAS
  • Publication number: 20190211423
    Abstract: A foil is manufactured as an aluminum alloy hard thin foil, wherein the aluminum alloy hard thin foil has an alloy composition wherein a content of Fe is 0.05 to 2.0% by mass, with the balance being aluminum and inevitable impurities; a recrystallization completion temperature is 250° C. or less; and a foil thickness of 5 to 50 ?m. The aluminum alloy hard thin foil can be obtained by subjecting an aluminum alloy having, for example, a composition wherein a total content of Cu, Mg, Cr and Zr is 0.05% by mass or less, and a content of Mn is 0.05% by mass or less to intermediate annealing once or more during cold rolling and subjecting the resulting alloy to cold rolling wherein a reduction ratio from after final intermediate annealing to after final cold rolling is 85% or more.
    Type: Application
    Filed: August 15, 2017
    Publication date: July 11, 2019
    Applicant: MITSUBISHI ALUMINUM CO., LTD.
    Inventor: Hiroaki NISHIDA
  • Publication number: 20190211424
    Abstract: The present invention relates to a powder for three-dimensional printing of a cermet or a cemented carbide body. The powder has 30-70 vol % of the particles that are <10 ?m in diameter. The present invention also relates to a method of making a cermet or cemented carbide body. The method includes the steps of forming the powder, 3D printing a body using the powder together with a printing binder to form a 3D printed cermet or cemented carbide green body and subsequently sintering the green body to form a cermet or cemented carbide body.
    Type: Application
    Filed: November 30, 2016
    Publication date: July 11, 2019
    Inventor: John DE FLON
  • Publication number: 20190211425
    Abstract: Provided is a method for producing alloy steel, the method comprising producing first alloy steel in a temperature holding furnace; maintaining the first alloy steel at a temperature of no lower than a melting point in the temperature holding furnace; and producing second alloy steel having an alloy content lower than the alloy content in the first alloy steel by melt mixing of the first alloy steel and molten steel. In the producing of the alloy steel, melting and storing of the ferroalloy are continuously performed, and thus, the temperature drop of the ferroalloy may be suppressed or prevented.
    Type: Application
    Filed: December 16, 2016
    Publication date: July 11, 2019
    Inventors: Woong Hee HAN, Chong Tae AHN, Soo Chang KANG, Jun Jeong BEAK, Min Ho SONG
  • Publication number: 20190211426
    Abstract: A spheroidal graphite cast iron having an excellent impact strength at low temperature and a method for producing the same are provided. The present disclosure relates to the spheroidal graphite cast iron comprising: C: 3.5 mass % to 4.2 mass %; Si: 2.0 mass % to 2.8 mass %; Mn: 0.2 mass % to 0.4 mass %; Cu: 0.1 mass % to 0.7 mass %; Mg: 0.02 mass % to 0.06 mass %; Cr: 0.01 mass % to 0.15 mass %; and the balance: Fe and inevitable impurities, wherein Mn+Cr+Cu is 0.431 mass % to 1.090 mass %, a graphite nodule count is 230/mm2 or less, and a pearlite fraction is 30% to 85%.
    Type: Application
    Filed: December 27, 2018
    Publication date: July 11, 2019
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, AISIN TAKAOKA CO., LTD.
    Inventors: Takumi Hijii, Yoshimasa Ureshino, Hitoshi Sakuma, Gou Nakamura, Zhong-zhi Zhang
  • Publication number: 20190211427
    Abstract: A steel sheet according to an aspect of the present invention includes a predetermined chemical composition; in which a metallographic structure in a ¼ t portion contains residual austenite of 4 volume % to 70 volume %; [Mn]?/[Mn]ave>1.5 is satisfied in the ¼ t portion; f?s/f??0.30 and [C]Ă—[Mn]?0.15 are satisfied in the ¼ t portion.
    Type: Application
    Filed: September 21, 2016
    Publication date: July 11, 2019
    Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Kohichi SANO, Masafumi AZUMA, Mutsumi SAKAKIBARA, Akihiro UENISHI, Koutarou HAYASHI
  • Publication number: 20190211428
    Abstract: A hot-rolled or cold-rolled steel plate having a composition including, in weight percent: 0.6%?C?0.9%; 17%?Mn?22%; 0.2%?Al?0.9%; 0.2%?Si?1.1%; with 0.85%?Al+Si?1.6%; 1.2%?Cu?1.7%; S?0.030%; P?0.080%; N?0.1%; 0<Nb?0.25%; 0<V?0.5%; 0<Ti?0.5%; 0<Ni?2%; trace amounts?Cr?2% and B?0.010% is provided. A remainder of the composition includes iron and impurities resulting from production of the steel plate. A method for manufacturing a steel plate and use of the steel plate in the automotive industry is also provided.
    Type: Application
    Filed: March 18, 2019
    Publication date: July 11, 2019
    Inventors: Colin SCOTT, Philippe CUGY
  • Publication number: 20190211429
    Abstract: A martensitic stainless steel for a fuel injection member contains, in mass %, at least 0.35% and less than 0.50% of C, more than 0.20% and at most 0.40% of Si, 0.2-0.4% of Mn, 0.25% or less of Ni, 15.0-17.0% of Cr, more than 2.0% and at most 3.0% of Mo, 0.1-0.3% of W, 0.001-0.003% of B, and at least 0.15% and less than 0.20% of N, with the remainder comprising Fe and inevitable impurities, which include 0-0.025% of P, 0-0.005% of S, 0-0.2% of Cu, 0-0.05% of Al, 0-0.02% of Ti, 0-0.02% of Nb, 0-0.15% of V, 0-0.003% of O, and 0-0.001% of H.
    Type: Application
    Filed: July 5, 2017
    Publication date: July 11, 2019
    Applicant: Hitachi Metals, Ltd.
    Inventors: Toshihiro UEHARA, Akihiro TOJI
  • Publication number: 20190211430
    Abstract: A hot-rolled steel sheet for a heavy-wall, high-strength line pipe, the steel sheet having a chemical composition including, in mass %, C: 0.02 to 0.20%, Mn: 0.80 to 2.10%, Si: 0.01 to 0.50%, P: 0.034% or less, S: 0.0050% or less, Nb: 0.01 to 0.15%, Ti: 0.001 to 0.030%, and Al: 0.001 to 0.080%, the balance being Fe and incidental impurities, the steel sheet having a microstructure in which a main phase is a continuous cooling transformation structure and in which {001}? grains in a plane whose normal direction is the sheet width direction constitute an area fraction of 10% or less and have a combined size of 10 ?m or less, wherein the steel sheet has a tensile strength of 520 MPa or greater, and, in a drop weight tear test, a temperature at which a percent ductile fracture reaches 85% is ?25° C. or lower.
    Type: Application
    Filed: June 6, 2017
    Publication date: July 11, 2019
    Applicant: JFE Steel Corporation
    Inventors: Sota Goto, Hiroshi Nakata, Junji Shimamura
  • Publication number: 20190211431
    Abstract: An aluminum alloy for casting shaped aluminum alloy parts may comprise alloying elements of silicon and chromium and may be formulated to develop a dispersion strengthened and precipitation strengthened microstructure via heat treatment. The aluminum alloy may be formulated to develop a microstructure including an aluminum matrix phase and a fine-grained AlCrSi dispersoid phase when subjected to a solution heat treatment. The aluminum alloy also may be formulated to develop a microstructure including one or more Cu-containing precipitate phases when subjected to an aging heat treatment.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 11, 2019
    Inventors: Henry Zhan, Bin Hu
  • Publication number: 20190211432
    Abstract: The disclosure provides aluminum alloys having varying ranges of alloying elements and properties.
    Type: Application
    Filed: January 10, 2019
    Publication date: July 11, 2019
    Inventors: Abhijeet Misra, James A. Wright, Herng-Jeng Jou
  • Publication number: 20190211433
    Abstract: A method for producing an enhanced property integrally bladed rotor includes solution heat treating a stub-containing rotor hub forging; water quenching the solution heat treated stub-containing rotor hub; aging the water quenched stub-containing rotor hub forging; linear friction welding airfoils onto each of a multiple of stubs of the stub-containing rotor hub forging; and concurrently stress relieving the linear friction welds of each of the multiple of stubs within a predefined area while ensuring that a hub inner diameter does not exceed a predetermined temperature.
    Type: Application
    Filed: January 5, 2018
    Publication date: July 11, 2019
    Applicant: United Technologies Corporation
    Inventors: Daniel A. Bales, Andrew L. Haynes, Luke H. Rettberg
  • Publication number: 20190211434
    Abstract: A process comprising: (i) coating particles of silicon carbide, silicon nitride, boron carbide or boron nitride with a metal alloy or metal layer; (ii) agglomerating the particles of step (i); thermally spraying the agglomerated metal or metal alloy coated particles onto a substrate to provide a coating thereon.
    Type: Application
    Filed: August 16, 2017
    Publication date: July 11, 2019
    Applicant: SERAM COATINGS AS
    Inventors: Nuria ESPALLARGAS, Fahmi MUBAROK
  • Publication number: 20190211435
    Abstract: A number of variations may include a ferritic nitrocarburized part comprising steel, wherein the ferritic nitrocarburized steel has a tensile strength exceeding the parent steel material and sufficient ductility, bendability, and flangeability to support subsequent flanging and press-fitting of bushings. Exact strength increases and bendability will be dependent on exact process and alloy combinations.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 11, 2019
    Inventors: Michael L. Holly, Dennis Deciechi, James J. Gentile, David M. Cummings, Charles M. Enloe
  • Publication number: 20190211436
    Abstract: A method for manufacturing a vapor deposition mask (100) including a resin layer (10), and a magnetic metal body (20) formed on the resin layer (10), the method including the steps of: (A) providing a magnetic metal body (20) having at least one first opening (25); (B) providing a substrate (60); (C) forming a resin layer (10) by applying a solution including a resin material or a varnish of a resin material on a surface of a substrate (60), and then performing a heat treatment thereon; (D) securing the resin layer (10) formed on the substrate (60) on the magnetic metal body (20) so as to cover the at least one first opening (25); (E) forming a plurality of second openings (13) in a region of the resin layer (10) that is located in the at least one first opening (25) of the magnetic metal body (20); and (F) after the step (E), removing the substrate (60) from the resin layer (10).
    Type: Application
    Filed: January 31, 2017
    Publication date: July 11, 2019
    Applicant: Sakai Display Products Corporation
    Inventors: Koshi NISHIDA, Susumu SAKIO, Katsuhiko KISHIMOTO
  • Publication number: 20190211437
    Abstract: There is provided a vapor deposition mask including: a resin mask including a resin mask opening corresponding to a pattern to be produced by vapor deposition; and a metal layer partially positioned on one surface of the resin mask.
    Type: Application
    Filed: September 27, 2017
    Publication date: July 11, 2019
    Applicant: Dai Nippon Printing Co., Ltd.
    Inventors: Katsunari OBATA, Yasuko SONE, Kumiko HOKARI
  • Publication number: 20190211438
    Abstract: Method for producing a thermal barrier system on a metal substrate (1) of a turbo engine part, such as a high-pressure turbine blade, the thermal barrier system comprising at least one columnar ceramic layer (31, . . . , 3i, . . . , 3n), characterised in that the method comprises a step of compressing at least one of said at least one columnar ceramic layer (31, . . . 3i, . . . , 3n).
    Type: Application
    Filed: August 25, 2017
    Publication date: July 11, 2019
    Applicant: Safran
    Inventors: Nihad BEN SALAH, Jawad BADREDDINE, Aurélian JOULIA
  • Publication number: 20190211439
    Abstract: An alkali-metal dispenser to dispense highly pure rubidium in a high-vacuum environment while not negatively impacting the high-vacuum pressure level. The alkali-metal dispenser is operable in various vapor-deposition applications or to provide a highly pure elemental-alkali metal in cold-atom magneto-optical traps.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 11, 2019
    Inventors: David Hostutler, Matthew Bigelow, Rudolph N. Kohn, JR., Spencer Olson, Matthew Squires, Daniel R. Blakley, Eric Imhof, Brian Kasch, Mary Spanjers
  • Publication number: 20190211440
    Abstract: An apparatus for use in a coating process includes a chamber, a crucible configured to hold a coating material in the chamber, an energy source operable to heat the interior of the chamber, a coating envelope situated with respect to the crucible, and at least one gas manifold located near the coating envelope. The at least one gas manifold is configured to provide a gas screen between the coating envelope and the crucible.
    Type: Application
    Filed: March 18, 2019
    Publication date: July 11, 2019
    Inventors: Joseph A. DePalma, Mladen F. Trubelja, David A. Litton, Dmitri L. Novikov, Sergei F. Burlatsky
  • Publication number: 20190211441
    Abstract: The present disclosure discloses a storage device with a sealing function, including a storage box, a sealing cover, and an elastic member, the storage box is provided with an opening, the sealing cover is rotatably connected to the storage box, the sealing cover is used to seal the opening, the fixing end of the elastic member is connected to the storage box, the free end of the elastic member is configured to connect the sealing cover so that the sealing cover opens from the opening. The present disclosure further discloses a heating assembly, including a crucible and a storage device with a sealing function, wherein the storage device with a sealing function is accommodated in the crucible. The sealing cover is used to seal the opening of the storage box so as to prevent the active material in the storage box from being exposed to the air.
    Type: Application
    Filed: April 19, 2018
    Publication date: July 11, 2019
    Inventors: Xiaoping QIAO, Jinchuan LI
  • Publication number: 20190211442
    Abstract: Substrate carrier apparatus having a hard mask are disclosed herein. In some embodiments, a substrate carrier apparatus includes a carrier body having a support surface to support a substrate; and a mask assembly disposed above the support surface. The mask assembly includes an annular frame disposed atop the support surface; and a hard mask coupled to and disposed within the annular frame above the support surface, wherein the hard mask includes one or more openings arranged in a predetermined pattern and disposed through the hard mask, and wherein the hard mask includes a plurality of spacer elements extending from a bottom surface of the hard mask.
    Type: Application
    Filed: December 26, 2018
    Publication date: July 11, 2019
    Inventors: ALEXANDER LERNER, KIM VELLORE, AMI SADE, STEVEN SANSONI, ANDREW CONSTANT, KEVIN MORAES, ROEY SHAVIV, NIRANJAN KUMAR, JEFFREY BRODINE, MICHAEL KARAZIM
  • Publication number: 20190211443
    Abstract: A continuous method for manufacturing graphene films using a metal substrate, wherein a first surface of the metal substrate is heated such that a top layer of the first surface melts to form a molten metal layer, and devices for carrying out the same.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Inventor: Avetik HARUTYUNYAN