Patents Issued in July 16, 2019
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Patent number: 10351893Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. A delivery portion of the housing defines a delivery path between the reagent volume and the reaction chamber when the housing is coupled to the reaction chamber. The delivery path includes a protrusion such that the delivery path has a discontinuous inner surface. The actuator can be moved to convey a reagent from the reagent container into the reaction chamber via the delivery path.Type: GrantFiled: October 3, 2016Date of Patent: July 16, 2019Assignee: GeneWeave Biosciences, Inc.Inventors: Doran Donnelly, Werner Frei, Ryan Griswold, Lance Page, Shaunak Roy
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Patent number: 10351894Abstract: A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ?10 ?m flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region.Type: GrantFiled: November 20, 2015Date of Patent: July 16, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Dino Di Carlo, Soojung C. Hur, Albert J. Mach
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Patent number: 10351895Abstract: The present invention relates to a biological method for the dosage of peptidoglycans in a sample, especially a sample of glucose polymers.Type: GrantFiled: February 5, 2015Date of Patent: July 16, 2019Assignee: Roquette FreresInventors: Pierre Lanos, Marc Biguet, Roselyne Bernard, Fabrice Allain, Mathieu Carpentier, Agnès Denys, Héla Hacine-Gherbi
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Patent number: 10351896Abstract: Use of at least one chromogenic and/or fluorogenic carboxylesterase and/or triacylglycerol-lipase substrate, to detect bacteria of the Bacillus cereus group in a sample capable of containing them.Type: GrantFiled: December 23, 2014Date of Patent: July 16, 2019Assignee: BIOMERIEUXInventors: Marie Cellier, Marie-Pierre Bourguignon, Diane Halimi
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Patent number: 10351897Abstract: The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.Type: GrantFiled: February 13, 2015Date of Patent: July 16, 2019Assignee: BioVentures, LLCInventors: Laura P. James, Jack Hinson, Dean Roberts, Pritmohinder S. Gill
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Patent number: 10351898Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for imaging this epigenetic modification along a DNA molecule are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.Type: GrantFiled: January 5, 2014Date of Patent: July 16, 2019Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Yuval Ebenstein, Micha Fridman
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Patent number: 10351899Abstract: Provided are methods for detecting and analyzing polynucleotides in a biological sample or sample derived therefrom for example, using a synthetic template polynucleotide. In some aspects, a target polynucleotide in the sample hybridizes to the template polynucleotide and is extended by a polymerase, generating an extended target polynucleotide. In some examples, the extended target polynucleotide is amplified, for example, by polymerase chain reaction, and sequences of the target polynucleotide determined, for example, by priming in the region of the extended target polynucleotide generated by extension and sequencing towards the region having identity to the target polynucleotide. In some aspects, the target polynucleotide is thereby detected in the sample and its sequence identified.Type: GrantFiled: September 25, 2014Date of Patent: July 16, 2019Assignee: Bio-ID Diagnostics Inc.Inventor: Thuraiayah Vinayagamoorthy
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Patent number: 10351900Abstract: The present invention relates to a method for predicting causative factors (bacteria) of serious bacterial infectious diseases in a clinical sample containing bacteria-derived nano-sized extracellular vesicles, that is, nanovesicles, through the analysis of the genes contained in the nanovesicles. According to the present invention, information on bacteria of serious bacterial infection can be provided, a causative factor of the bacterial infection can be predicted, and the resistance of the bacteria to antibiotics can be predicted.Type: GrantFiled: December 10, 2015Date of Patent: July 16, 2019Assignee: MD HEALTHCARE INC.Inventors: Young Koo Jee, Yoon-Keun Kim, Young-Ju Kim, Hyeonil Choi, Mina Rho, Sungmin Kiem
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Patent number: 10351901Abstract: A microfluidic processing device includes a substrate defining a microfluidic network. The substrate is in thermal communication with a plurality of N independently controllable components and a plurality of input output contacts for connecting the substrate to an external controller. Each component has at least two terminals. Each terminal is in electrical communication with at least one contact. The number of contacts required to independently control the N components is substantially less than the total number of terminals. Upon actuation, the components typically heat a portion of the microfluidic network and/or sense a temperature thereof.Type: GrantFiled: June 12, 2017Date of Patent: July 16, 2019Assignee: HandyLab, Inc.Inventors: Karthik Ganesan, Kalyan Handique
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Patent number: 10351903Abstract: Methods are provided for nucleic acid analysis. In an illustrative method, allele amplification bias is used to amplify preferentially a target nucleic acid that is present in a low allele fraction.Type: GrantFiled: May 24, 2016Date of Patent: July 16, 2019Assignee: University of Utah Research FoundationInventors: Luming Zhou, Robert Andrew Palais
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Patent number: 10351904Abstract: The present invention relates a composition, including an RNA probe which contains a fluorescence material absorbed in graphene oxide, for detecting a nucleic acid, and to a method for detecting a nucleic acid using the composition. By means of the composition and the method, the presence and expression pattern of a target nucleic acid in a sample or a cell can be observed in real time, and a plurality of target nucleic acids can be detected in multitude.Type: GrantFiled: April 24, 2013Date of Patent: July 16, 2019Assignee: SNU R&DB FOUNDATIONInventors: Dal-Hee Min, Jieon Lee, Soo-Ryoon Ryoo
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Patent number: 10351905Abstract: The invention generally relates to detecting target molecules.Type: GrantFiled: April 19, 2013Date of Patent: July 16, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Darren Roy Link, Benjamin J. Miller
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Patent number: 10351906Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.Type: GrantFiled: October 27, 2016Date of Patent: July 16, 2019Assignee: Natera, Inc.Inventors: Bernhard Zimmermann, Matthew Hill, Philippe Lacroute, Michael Dodd, Alexander Wong
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Patent number: 10351907Abstract: According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.Type: GrantFiled: October 16, 2014Date of Patent: July 16, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: George A. Fry, Christina E. Inman, John Bridgham, Timothy Hunkapiller, Charles S. Vann
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Patent number: 10351908Abstract: Described herein are variants of alpha-hemolysin having at least one mutation, such as a mutation to a positive charge. In certain examples, the mutation is selected from V149K, E287R, H35G, T109K, P151K, K147N, E111N, M113A, or combinations thereof in the mature, wild-type alpha-hemolysin amino acid sequence. The ?-hemolysin variants may also include a substitution at H144A and/or a series of glycine residues spanning residues 127 to 131 of the mature, wild-type alpha hemolysin. Also provided are nanopore assemblies including the alpha-hemolysin variants, the assembly having a decreased time-to-thread. The decreased time-to-thread, for example, increases DNA sequencing efficiency and accuracy.Type: GrantFiled: April 20, 2017Date of Patent: July 16, 2019Assignee: ROCHE SEQUENCING SOLUTIONS, INC.Inventors: Timothy K. Craig, Mark R. Ambroso, Corissa J. Harris, Matthew M. Dipietro, Yaozhong Zou, Marshall W. Porter
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Patent number: 10351909Abstract: The invention relates to an automated method for high-throughput DNA sequencing from high density DNA arrays by (a) initiating a first sequencing reaction on a first high density DNA array; and imaging said first high density DNA array using a detector, and (b) initiating a first sequencing reaction on a second high density DNA array; and imaging said second high density DNA array using the detector, wherein the first sequencing reaction in (a) is initiated before the first sequencing reaction in (b) is initiated such that the sequencing reactions in (a) and (b) are staggered. By using asynchronous sequencing reactions and imaging two separate arrays using one detector, imaging can be carried out on one array while sequencing reactions are carried out on one the other, substrate, the other substrate is imaged, reducing the idle time of the imaging system.Type: GrantFiled: February 25, 2017Date of Patent: July 16, 2019Assignee: Complete Genomics, Inc.Inventors: Radoje Drmanac, Matthew J. Callow, Snezana Drmanac, Brian K. Hauser, George Yeung
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Patent number: 10351910Abstract: Adherent stromal cells cultured under three dimensional conditions are provided, characterized, and distinguished from adherent stromal cells cultured under two dimensional conditions.Type: GrantFiled: February 20, 2014Date of Patent: July 16, 2019Assignee: PLURISTEM LTDInventors: Rachel Ofir, Eytan Abraham
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Patent number: 10351911Abstract: Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.Type: GrantFiled: April 24, 2016Date of Patent: July 16, 2019Assignees: Technion Research & Development Foundation Limited, Ramot at Tel-Aviv University Ltd., Walter Gabriel WASSER, Rambam Med-Tech Ltd.Inventors: Karl Skorecki, Shay Tzur, Saharon Rosset, Walter Gabriel Wasser, Doron M. Behar, Revital Shemer
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Patent number: 10351912Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.Type: GrantFiled: October 24, 2011Date of Patent: July 16, 2019Assignee: Abbott Molecular Inc.Inventors: Irina A. Sokolova, Steven A. Seelig, Larry E. Morrison, Walter King, Alicia Algeciras-Schimnich
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Patent number: 10351913Abstract: In certain aspects, the disclosure relates to methods of predicting recurrence of colorectal cancer by using a combination of microRNAs in the circulation, wherein the microRNAs are selected from the group consisting of miR-15a, miR-103, miR-148a, miR-320a, miR-451 and miR-596. In other aspects, the disclosure relates to methods of treating colorectal cancer by administering a therapeutic agent after determining an increased risk of recurrence.Type: GrantFiled: October 7, 2014Date of Patent: July 16, 2019Assignee: Georgetown UniversityInventors: Anton Wellstein, Narayan Shivapurkar
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Patent number: 10351914Abstract: Biomarkers and driver mutations for diagnosis and prognosis of Pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of Pin 1-associated diseases may include detecting the level of Pin1 to stage abnormal cell growth, such as breast or prostate cancer. In another embodiment, the methods include evaluating the efficacy of a treatment of abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the methods include using driver mutations to determine the pharmacogenetics of abnormal cell growth, such as cancer. In the present disclosure, elevated active monomeric Pin1 levels may be detected by Pin1 biomarkers, which may include Pin1 Q33K or E100D driver mutations, Pin1 protein or transcript overexpression, dephosphorylation of Pin1 on Ser71, dephosphorylation of S16, phosphorylation of S65, phosphorylation of S138, deacetylation of Pin1 on K13 and deacetylation of K46, and/or desumoylation of Pin1 on K6 and desumolation of K63, among others.Type: GrantFiled: July 16, 2015Date of Patent: July 16, 2019Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Kun Ping Lu, Xiao Zhen Zhou, Shuo Wei
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Patent number: 10351915Abstract: Methods and formulations for treating onocological disorders in humans using Coenzyme Q10 are described.Type: GrantFiled: January 5, 2018Date of Patent: July 16, 2019Inventors: Niven Rajin Narain, John Patrick McCook
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Patent number: 10351916Abstract: The present invention relates to methods for the identification of anti-HIV miRNAs and anti-HIV pharmaceutical compounds using high-throughput screening methods, comprising: transfecting reporter cells with a panel of miRNAs, infecting the reporter cells with HIV, screening the cells to identify miRNAs that modulate HIV infection and identifying the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs. The invention further provides for the identification and screening of anti-HIV pharmaceutical compounds having known activity against the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs for efficacy in the treatment of HIV. The invention also provides for the use of miRNA mimics, miRNA inhibitors and pharmaceutical compounds (including oncology drugs and kinase inhibitors) in the treatment and/or prevention of HIV infection.Type: GrantFiled: April 25, 2018Date of Patent: July 16, 2019Assignee: CSIRInventors: Jerolen Naidoo, Samantha Barichievy, Rethabile Khutlang, Musa M Mhlanga
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Patent number: 10351917Abstract: The present invention provides methods and compositions for identifying soybean plants that are tolerant or have improved tolerance, or those that are susceptible to, iron deficient growth conditions. The methods use molecular markers to identify, select, and/or introgress genetic loci modulating phenotypic expression of an iron deficiency tolerance trait in soybean plant breeding. Methods are provided for screening germplasm entries for the performance and expression of this trait.Type: GrantFiled: August 29, 2012Date of Patent: July 16, 2019Assignee: Monsanto Technology LLCInventors: Vergel C. Concibido, Susannah G. Cooper, David Hoffman, Hongwu Jia, Thomas Jury, Bradley LaVallee, Roger L. Lussenden, Xianghai Ye
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Patent number: 10351918Abstract: The invention relates to a novel pathogenesis model, method, or kit for detecting pathogenesis in a subject. In particular, the invention provides a pathogen index derived from a ratio of the amount of dual pathogen targets relative to the amount of host quantitative measures. The pathogen index is used in diagnosis, prognosis, and/or treatment strategy of any disease, including citrus greening diseases (HLB). Research tools and methods for screening drugs for treating or preventing citrus greening diseases, as well as treatment or prevention methods for citrus greening diseases are also provided.Type: GrantFiled: October 30, 2014Date of Patent: July 16, 2019Assignee: GREEN LIFE BIOTECH, LLCInventor: Robert M. Lloyd, Jr.
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Patent number: 10351919Abstract: The present invention relates to an elongated pelt board for accommodating an animal pelt. The pelt board comprises a first wall element, a second wall element being spaced apart from the first wall element in the first radial direction, a third wall element and a fourth wall element being spaced apart from the third wall element in a second radial direction. The wall elements together define a cavity along a longitudinal direction. The wall elements defining a contracted state in which the first and second radial distances are reduced, and an expanded state in which the first and second radial distances are increased. The pelt board further comprising an elongated core element being movable in relation to each of the wall elements. The elongated core element allows the wall elements to selectively define the contracted state or the expanded state by moving the elongated core element in the longitudinal direction.Type: GrantFiled: March 25, 2015Date of Patent: July 16, 2019Assignee: MINKPAPIR A/SInventors: Johnny Larsen, Soren Frolund, Mogens Fahlgren Andersen, Soren Korsgaard
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Patent number: 10351920Abstract: The present invention relates to a particulate inoculant for treating liquid cast-iron, comprising, on the one hand, support particles made of a fusible material in the liquid cast-iron, and on the other hand, surface particles made of a material that promotes the germination and the growth of graphite, disposed and distributed in a discontinuous manner at the surface of the support particles, the surface particles presenting a grain size distribution such that their diameter d50 is smaller than or equal to one-tenth of the diameter d50 of the support particles.Type: GrantFiled: March 19, 2014Date of Patent: July 16, 2019Assignee: PERROPEMInventors: Thomas Margaria, Aurelie Fay
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Patent number: 10351921Abstract: A martensitic stainless steel alloy is strengthened by copper-nucleated nitride precipitates. The alloy includes, in combination by weight percent, about 10.0 to about 12.5 Cr, about 2.0 to about 7.5 Ni, up to about 17.0 Co, about 0.6 to about 1.5 Mo, about 0.5 to about 2.3 Cu, up to about 0.6 Mn, up to about 0.4 Si, about 0.05 to about 0.15 V, up to about 0.10 N, up to about 0.035 C, up to about 0.01 W, and the balance Fe and incidental elements and impurities. The nitride precipitates may be enriched by one or more transition metals. A case hardened, corrosion resistant variant has a reduced weight percent of Ni, enabling increased use of Cr, and decreased Co.Type: GrantFiled: November 21, 2017Date of Patent: July 16, 2019Assignee: QuesTek Innovations LLCInventors: David R. Snyder, Jiadong Gong, Jason T. Sebastian, James A. Wright, Herng-Jeng Jou, Zechariah Feinberg
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Patent number: 10351922Abstract: Alloys, a process for preparing the alloys, and manufactured articles including the alloys are described herein. The alloys include, by weight, about 11.5% to about 14.5% chromium, about 0.01% to about 3.0% nickel, about 0.1% to about 1.0% copper, about 0.1% to about 0.2% carbon, about 0.01% to about 0.1% niobium, 0% to about 5% cobalt, 0% to about 3.0% molybdenum, and 0% to about 0.5% titanium, the balance essentially iron and incidental elements and impurities.Type: GrantFiled: April 21, 2015Date of Patent: July 16, 2019Assignee: QuesTek Innovations LLCInventors: David R. Snyder, Jiadong Gong, Jason T. Sebastian, James A. Wright, Herng-Jeng Jou, Zechariah Feinberg
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Patent number: 10351924Abstract: A hot-dip galvanized steel sheet includes a base steel sheet and a hot-dip galvanized layer formed on the base steel sheet, the base steel sheet including, by wt %, C:0.02% to 0.08%, Mn:1.3% to 2.1%, Si:0.3% or less (excluding 0%), Cr:1.0% or less (excluding 0%), P:0.1% or less (excluding 0%), S: 0.01% or less (excluding 0%), N:0.01% or less (excluding 0%), sol.Al: 0.02% to 0.06%, Mo:0.2% or less (excluding 0%), B:0.003% or less (excluding 0%), and a balance of Fe and inevitable impurities, wherein the base steel sheet has a microstructure comprising 90% or more by area of ferrite, 3% or less by area of bainite as described in Formula 1, and martensite as a remainder.Type: GrantFiled: May 8, 2015Date of Patent: July 16, 2019Assignee: POSCOInventors: Sang-Ho Han, Seong-Ho Han
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Patent number: 10351925Abstract: A steel plate excellent in acid dew point corrosion resistance has a composition, in mass percent, from 0.001 to 0.15% of C, 0.80% or less of Si, 1.50% or less of Mn, 0.025% or less of P, 0.030% or less of S, from 0.10 to 1.00% of Cu, 0.50% or less of Ni, from 0.05 to 0.25% of Cr, 0.01 to 0.08% of Mo, 0.100% or less of Al, from 0 to 0.20% in total of Ti, Nb, and V, from 0 to 0.010% of B, from 0 to 0.10% in total of Sb and Sn, and a balance of Fe and unavoidable impurities, having a ferrite single phase structure, or a structure containing 30% by volume or less in total of one or more of cementite, pearlite, bainite, and martensite, with the balance ferrite phase. Ferrite crystal grains have an average crystal grain diameter of 12.0 mm or less.Type: GrantFiled: March 26, 2015Date of Patent: July 16, 2019Assignee: NIPPON STEEL NISSHIN CO., LTD.Inventors: Yukio Katagiri, Akito Kawamoto, Susumu Fujiwara
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Patent number: 10351926Abstract: A thick steel plate is provided by heating a continuously-cast slab, hot forging the continuously-cast slab using opposing dies having respective short sides differing such that when a short side length of a die having a shorter one of the short sides is taken to be 1, a short side length of a die having a longer one of the short sides is 1.1 to 3.0, allowing cooling to obtain a steel raw material, reheating the steel raw material, performing hot rolling of the steel raw material including at least two passes carried out, allowing cooling to obtain a thick steel plate, reheating the thick steel plate to at least the Ac3 temperature and no higher than 1050° C., rapidly cooling the thick steel plate to 350° C. or lower, and tempering the thick steel plate at at least 550° C. and no higher than 700° C.Type: GrantFiled: November 17, 2015Date of Patent: July 16, 2019Assignee: JFE STEEL CORPORATIONInventors: Yota Kuronuma, Hirofumi Ohtsubo, Shigeki Kitsuya, Katsuyuki Ichimiya, Kazukuni Hase
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Patent number: 10351927Abstract: The present invention relates to a hot-rolled steel sheet for a high strength galvanized steel sheet, having excellent surface quality, and a method for producing the same, the hot-rolled steel sheet comprising, by weight %: C: 0.05 to 0.15%, Si: 0.03 to 0.10%, Mn: 0.7 to 1.39%, P: 0.001 to 0.05%, S: 0.001 to 0.03%, Al: 0.002 to 0.035%, and the remainder being Fe and unavoidable impurities. The weight ratio of Mn/Si is 15 to 25, the weight ratio of C/Si is 1 to 5, and the weight ratio of Si/P is 3 to 10. The hot-rolled steel sheet has a microstructure consisting of, in area fraction, 10 to 40% of bainite, 20 to 30% of pearlite and 40 to 60% of ferrite, and includes a ternary eutectic compound of FeO, Fe2SiO4 and Fe3(PO)4 formed within 50 ?m from the surface.Type: GrantFiled: December 24, 2014Date of Patent: July 16, 2019Assignee: POSCOInventors: Hyo Jung Kwak, Young-Ha Kim, Seok Jong Seo
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Patent number: 10351928Abstract: A resistance annealing furnace for annealing a metal wire, strand, string, wire rod or strap having at least two electric axes, which are provided with respective pulleys for conveying the metal wire, and DC voltage generator means suppliable by an AC voltage source to generate an annealing voltage applied between the two electric axes. The DC voltage generator means has a first voltage rectifier stage connectable to the AC voltage source to generate an intermediate DC voltage, an active power filter, connected so as to compensate the current harmonics at the input of the first voltage rectifier stage, a pulse width modulator to transform the intermediate voltage into a first PWM voltage, a voltage transformer to transform the first PWM voltage into a corresponding second PWM voltage, and second voltage rectifier means to transform the second modulated PWM voltage into the annealing voltage.Type: GrantFiled: November 4, 2014Date of Patent: July 16, 2019Assignee: SAMP S.P.A. CON UNICO SOCIOInventors: Artemio Affaticati, Roberto Conte
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Patent number: 10351929Abstract: Provided are a sulfuric acid adding facility and an operation method therefor which enable an increase in the maximum capacity and the operation rate of a sulfuric acid supply pump provided in the sulfuric acid adding facility. In a sulfuric acid adding facility, sulfuric acid is added to an autoclave used in a leaching step of a high pressure acid leaching method for a nickel oxide ore. The sulfuric acid adding facility is provided with the same number (n+1) (n is an integer, at least 1) of each of the following: a plurality of sulfuric acid adding pipes for adding sulfuric acid into the autoclave; and a plurality of sulfuric acid supply pumps for supplying sulfuric acid to the sulfuric acid adding pipes. Each of the first through n+1th sulfuric acid supply pumps includes at least three diaphragms and discharge ports of the same number as that of the diaphragms.Type: GrantFiled: February 8, 2016Date of Patent: July 16, 2019Assignee: SUMITOMO METAL MINING CO., LTD.Inventors: Takashi Sakamoto, Osamu Nakai, Masayuki Oku, Hideaki Sato, Sho Shirai
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Patent number: 10351930Abstract: The present invention according provides a method of recovering silver from silver containing halide solutions, comprising the steps of: (a) providing an ion exchange column comprising a weak anion exchange resin; (b) introducing the silver containing halide solution to the ion exchange column to absorb silver in the weak anion exchange resin; (c) washing the loaded ion exchange resin with a first washing solution to rinse off absorbed zinc and optionally at least part of copper; (d) washing the loaded ion exchange resin with a second washing solution to rinse off remaining copper; and (e) optionally washing the loaded ion exchange resin with a third washing solution to rinse off absorbed lead; and (f) eluting the loaded ion exchange resin with an eluent to remove silver from the resin and to obtain a silver containing solution.Type: GrantFiled: June 4, 2015Date of Patent: July 16, 2019Assignee: OUTOTEC (FINLAND) OYInventors: Kari Valkama, Mika Haapalainen, Mikko Tyster, Sami Virolainen
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Patent number: 10351931Abstract: Extraction of rare earths from end-of-use machinery having rare earth magnets provides a closed-loop process towards recycling rare earths from commingled devices having embedded magnets such as motors, generators and disk drives. A low temperature process selectively leaches the magnet material from mixed scrap containing shredded fragments of the machinery which includes other metals such as steel and copper. Filtration separates the other metals from the leached, dissolved magnet material, which is precipitated by oxalic acid to form oxalates in powder form, suitable for use in production of new rare earth magnetic material. Leaching acid, such as HCl (hydrochloric acid), is recoverable via pyrohydrolysis, and redirected back to the leaching step for completing the closed-loop aspect.Type: GrantFiled: January 15, 2016Date of Patent: July 16, 2019Assignee: Worcester Polytechnic InstituteInventors: Marion H. Emmert, H. M. Dhammika Bandara
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Patent number: 10351932Abstract: The present invention controls the fluctuations of Ti concentration in a copper titanium alloy from a perspective different from conventional perspectives to improve the strength and bending workability of the copper titanium alloy. A copper titanium alloy for electronic components comprising 2.0 to 4.0 mass % of Ti, and 0 to 0.5 mass %, in total, of one or more elements selected from the group consisting of Fe, Co, Mg, Si, Ni, Cr, Zr, Mo, V, Nb, Mn, B, and P as a third element, with the balance being copper and unavoidable impurities, wherein a coefficient of variation in a Ti concentration fluctuation curve is 0.2 to 0.Type: GrantFiled: September 11, 2014Date of Patent: July 16, 2019Assignee: JX Nippon Mining & Metals CorporationInventor: Hiroyasu Horie
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Patent number: 10351933Abstract: Disclosed is a brass that possesses high corrosion resistance even without undergoing a heat treatment step contemplated for dezincification corrosion suppression. This brass includes 55% by mass to 75% by mass of Cu (copper), 0.01% by mass to 1.5% by mass of Si (silicon), Sn (tin) and Al (aluminum) in such amounts as to satisfy a prescribed relationship with an apparent Zn content, less than 0.25% by mass of Mn (manganese) as an optional ingredient, less than 0.05% by mass of Ti (titanium) as an optional ingredient, less than 0.3% by mass of Mg (magnesium) as an optional ingredient, less than 0.15% by mass of P (phosphorus) as an optional ingredient, and less than 0.004% by mass of a rare earth metal as an optional ingredient with the balance consisting of Zn (zinc) and unavoidable impurities, the apparent zinc content being 37 to 45.Type: GrantFiled: February 1, 2013Date of Patent: July 16, 2019Assignee: Toto Ltd.Inventor: Toru Uchida
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Patent number: 10351934Abstract: A method for manufacturing a nonlinear superelastic file comprising the steps of: providing a superelastic file having a shaft and a file axis; providing a fixture including a file groove being defined by one or more displacement members, the file groove configured for receiving the shaft; inserting at least a portion of the shaft into the fixture along the file groove, the portion of the shaft including a first portion of the shaft; contacting the first portion of the shaft with a first displacement member of the one or more displacement members such that the first portion of the shaft is displaced from the file axis thereby forming a first offset portion of the shaft; heating the portion of the shaft while inserted in the fixture to a temperature of at least about 300° C. for a time period of at least about 1 minute to shape-set the portion of the shaft thereby forming a shape-set nonlinear file.Type: GrantFiled: November 14, 2014Date of Patent: July 16, 2019Assignee: DENTSPLY SIRONA Inc.Inventors: Dan Ammon, Vincent Shotton, Yong Gao, Randall Maxwell
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Patent number: 10351935Abstract: Provided is a magnetic compound represented by the formula (R(1-x)Zrx)a(Fe(1-y)Coy)bTcMdAe (wherein R represents one or more rare earth elements, T represents one or more elements selected from the group consisting of Ti, V, Mo, and W, M represents one or more elements selected from the group consisting of unavoidable impurity elements, Al, Cr, Cu, Ga, Ag, and Au, A represents one or more elements selected from the group consisting of N, C, H, and P, 0?x?0.5, 0?y?0.6, 4?a?20, b=100?a?c?d, 0<c<7, 0?d?1, and 1?e?18), in which a main phase of the magnetic compound includes a ThMn12 type crystal structure, and a volume percentage of an ?-(Fe,Co) phase is 20% or lower.Type: GrantFiled: September 3, 2015Date of Patent: July 16, 2019Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Noritsugu Sakuma, Akira Kato, Kota Washio, Hidefumi Kishimoto, Masao Yano, Akira Manabe, Masaaki Ito, Shunji Suzuki, Kurima Kobayashi
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Patent number: 10351936Abstract: A high-strength hot-dip galvanized steel sheet containing a main component, the steel sheet having at least 40 wt. % of ferrite as a main phase in terms of the volumetric ratio, and 8-60% inclusive of residual austenite, the remaining structure comprising one or more of bainite, martensite, or pearlite. Austenite particles within a range where the average residual stress (sigmaR) thereof satisfies the expression ?400 MPa<=sigmaR<=200 MPa (formula (1)) are present in an amount of 50% or more in the hot-dip galvanized steel sheet. The surface of the steel sheet has a hot-dip galvanized layer containing less than 7 wt. % of Fe, the remainder comprising Zn, Al and inevitable impurities.Type: GrantFiled: December 12, 2016Date of Patent: July 16, 2019Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Koichi Sato, Shintaro Yamanaka, Soshi Fujita
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Patent number: 10351937Abstract: The present invention provides a high-strength steel sheet excellent in impact resistance. The high-strength steel sheet contains predetermined contents of C, Si, Mn, P, S, Al, Ti, N, and O, with the balance being iron and inevitable impurities, and has a steel sheet structure in which, in a ? thickness to ? thickness region across ¼ of a sheet thickness, 1 to 8% retained austenite is contained in volume fraction, an average aspect ratio of the retained austenite is 2.0 or less, an amount of solid-solution Mn in the retained austenite is 1.1 times an average amount of Mn or more, and TiN grains having a 0.5 ?m average grain diameter or less are contained, and a density of AlN grains with a 1 ?m grain diameter or more is 1.0 pieces/mm2 or less, wherein a maximum tensile strength is 900 MPa or more.Type: GrantFiled: July 27, 2012Date of Patent: July 16, 2019Assignee: NIPPON STEEL CORPORATIONInventors: Hiroyuki Kawata, Naoki Maruyama, Akinobu Murasato, Akinobu Minami, Hajime Hasegawa, Chisato Wakabayashi, Tsuyoshi Oki
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Patent number: 10351938Abstract: Iron-based metallurgical powders comprising vanadium are described, as well as compacted articles made thereof. These articles have improved mechanical properties.Type: GrantFiled: April 6, 2016Date of Patent: July 16, 2019Assignee: Hoeganaes CorporationInventors: Christopher T. Schade, Bruce Lindsley, Thomas F. Murphy, Wing-Hong Chen
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Patent number: 10351939Abstract: A Cu—Al—Mn-based alloy having superelastic characteristics and having a recrystallized texture substantially formed of a ? single phase, in which 70% or more of crystal grains is within a range of 0° to 50° in a deviation angle from <001> orientation of a crystalline orientation measured in a working direction by electron back-scatter diffraction patterning.Type: GrantFiled: March 16, 2015Date of Patent: July 16, 2019Assignees: TOHOKU UNIVERSITY, FURUKAWA TECHNO MATERIAL CO., LTD., FURUKAWA ELECTRIC CO., LTD.Inventors: Toshihiro Omori, Shingo Kawata, Ryosuke Kainuma, Kiyohito Ishida, Toyonobu Tanaka, Kenji Nakamizo, Sumio Kise, Koji Ishikawa, Misato Nakano, Satoshi Teshigawara
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Patent number: 10351940Abstract: A method of manufacturing a component from a nickel-based superalloy comprises the steps of: providing a vacuum induction casting furnace; positioning a component mould onto a chill plate within the furnace; casting a component blank; peening the surface of the component blank; applying a surface modification technique to the surface of the component blank; solution heat treating the component blank at or above the ??-solvus temperature for the superalloy; and precipitation heat treating the component blank.Type: GrantFiled: August 24, 2017Date of Patent: July 16, 2019Assignee: ROLLS-ROYCE plcInventor: John H Boswell
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Patent number: 10351941Abstract: An object of the present invention is to provide an ?+? titanium alloy cold-rolled and annealed sheet having a high strength and a high Young's modulus in the sheet width direction. A titanium alloy sheet in which, when the texture in the sheet plane direction is analyzed, the ratio XTD/XND between the X-ray relative intensity peak value (XTD) in directions close to the sheet width direction and the X-ray relative intensity peak value (XND) in directions close to the normal-to-sheet-plane direction on the (0002) pole figure of the ?-phase is 5.0 or more and which contains, in mass %, Fe: 0.8% to 1.5% and N: 0.020% or less and has an oxygen-equivalent Q of 0.34 to 0.55. Annealing of the titanium alloy sheet is performed at not less than 500° C. and less than 800° C. in the case where the cold rolling rate is less than 25% and at not less than 500° C. and less than 620° C. in the case where the cold rolling rate is 25% or more.Type: GrantFiled: April 9, 2015Date of Patent: July 16, 2019Assignee: NIPPON STEEL CORPORATIONInventors: Akira Kawakami, Kazuhiro Takahashi, Hideki Fujii
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Patent number: 10351942Abstract: In a high strength hot-dip galvannealed hot-rolled steel sheet that has an excellent hole expansibility suitable for a stretch flanging and preferably has a high yield ratio and a tensile strength of at least 650 MPa, a hot-rolled steel sheet used as a base material for plating has a chemical composition comprising: in mass %, C: from at least 0.01 and at most 0.20%; Si: at most 0.50%; Mn: from at least 0.01% to at most 1.30%; P: at most 0.05%; S: at most 0.01%; N: at most 0.01%; Al: at most 0.50%; and Ti: from at least 0.05% to at most 0.50%, and a steel structure consisting of a polygonal ferrite having at least 80 area % and the remainder containing one kind or two or more kinds selected from bainitic ferrite, bainite, pearlite, and cementite.Type: GrantFiled: September 11, 2012Date of Patent: July 16, 2019Assignee: NIPPON STEEL & SUMITOMO METAL CORPORATIONInventors: Takafumi Yokoyama, Shigeki Nomura
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Patent number: 10351943Abstract: A Mg-containing Zn alloy coated steel including a steel and a metallic coating layer placed on a surface of the steel, in which the metallic coating layer is a layered structure of plural flat-form metal particles having a particle diameter of from 5 to 100 ?m, and a thickness of from 0.5 to 30 ?m, the composition of the metal particles include Zn from 11 to 80 mass %, Al from 3 to 80 mass %, Mg from 8 to 45 mass %, and Ca from 1 to 5 mass %, and the Zn, Al, and Mg content satisfy Zn+Al>Mg, and in which the metal particles include a quasicrystalline phase, an MgZn2 phase, and optionally a balance structure.Type: GrantFiled: September 29, 2016Date of Patent: July 16, 2019Assignee: NIPPON STEEL CORPORATIONInventors: Nobuyuki Shimoda, Kohei Tokuda, Kenichiro Matsumura, Yasuto Goto
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Patent number: 10351944Abstract: Ferrous alloys and methods of forming the ferrous alloys are disclosed. A ferrous alloy material may include iron and boron and an outer case layer. The outer case layer may have an average grain size of ASTM 9 or finer and may have a case thickness of at least 0.001 inches. The boron concentration of the outer case layer may be greater than a boron concentration of a core of the material. The ferrous alloy material may also include a nitrogen scavenging agent and may have a nitrogen concentration in the outer case layer that is greater than a nitrogen concentration in the core of the material. The alloy may be formed by performing a carburizing step and a nitriding step above the upper critical temperature on a boron steel. The method may include a single heat and quench cycle.Type: GrantFiled: May 28, 2015Date of Patent: July 16, 2019Assignee: ArvinMeritor Technology, LLCInventors: Danielle Rickert, Kenneth K. Yu