Patents Issued in August 1, 2019
  • Publication number: 20190233888
    Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Philip Justus Wunderle, Chungsoo Charles Park, David King, Dennis Lehto
  • Publication number: 20190233889
    Abstract: A DNA library with excellent reproducibility is readily produced. A nucleic acid amplification reaction is conducted in a reaction solution containing genomic DNA and a random primer at a high concentration to obtain a DNA fragment by the nucleic acid amplification reaction using the genomic DNA as a template.
    Type: Application
    Filed: April 3, 2017
    Publication date: August 1, 2019
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Hiroyuki ENOKI, Yoshie TAKEUCHI
  • Publication number: 20190233890
    Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
  • Publication number: 20190233891
    Abstract: A method for determining the association of Human Leukocyte Antigen (HLA) alleles at adjacent loci in genomic DNA from a biological sample obtained from a human subject is disclosed. A method and system of validating correctness of an assignment of an allele variant to a genetic human leucocyte antigen (HLA) locus are also disclosed.
    Type: Application
    Filed: September 26, 2017
    Publication date: August 1, 2019
    Applicant: Sirona Genomics, Inc.
    Inventors: Chunlin WANG, Ming LI
  • Publication number: 20190233892
    Abstract: The presence of certain auto antibodies and miRNAs indicates that a subject has endometriosis. The auto-antibodies recognise antigens listed in Table 1. The miRNAs are also listed in Table 1.
    Type: Application
    Filed: September 17, 2018
    Publication date: August 1, 2019
    Inventors: Finbar Cotter, Christine Deguara, Colin Davis
  • Publication number: 20190233893
    Abstract: The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis.
    Type: Application
    Filed: December 4, 2018
    Publication date: August 1, 2019
    Inventor: LINDA C. GIUDICE
  • Publication number: 20190233894
    Abstract: A method for the diagnosis or prognosis of Alzheimer's disease (AD), includes the steps of placing a sample isolated from a person suspected of having AD onto a substrate labeling the sample to identify at least one epigenetic marker and/or genetic variation and determining a state of AD. One of the epigenetic markers is PM20D1 promoter DNA methylation and/or one of the genetic variation is in at least one of PM20D1 mQTL-associated SNPs. PM20D1 is used as a therapeutic target and viral vectors encoding PM20D1 are used in the therapy of AD. Moreover, a kit for diagnosing AD includes reagents for detecting the SNPs rs708727, rs947211, rs708730, rs708724 or rs823130.
    Type: Application
    Filed: July 14, 2017
    Publication date: August 1, 2019
    Inventors: Jose Vicente SACHEZ MUT, Johannes GRÄFF, Holger HEYN, Manuel ESTELLER BADOSA
  • Publication number: 20190233895
    Abstract: In an aspect, a method includes obtaining patient data for a patient, the patient data including one or more molecular biomarkers specific to the patient, standardizing and curating the patient data, classifying the standardized and curated patient data including classifying the one or more molecular biomarkers by one or more of its functional effects, using the one or more functional effects for the one or more molecular biomarkers to identify a combination of available therapeutic options by targeting biomarkers with relevant functional effects based on the patient data, applying a learning method to optimize results for presentation to a user, and presenting optimized results to the user.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 1, 2019
    Inventors: Razelle Kurzrock, Igor Flint Tsigelny, Amélie Clémence Boichard, Sergey Kozhenkov, Kevin Toivo Bush, Timothy Viet Pham, Stephane Richard
  • Publication number: 20190233896
    Abstract: The present invention relates to a method for estimating the risk factor (HR) for the onset of macular degeneration in a subject, which method comprises the evaluation of a first series of genetic parameters comprising at least the genetic loci R1210C in CFH, variants in COL8A1 and RAD51 B, and the evaluation of a second series of environmental, individual and/or clinical parameters. This method is characterized in that said risk factor (HR) is calculated by assigning a greater importance to said evaluation of the first series of genetic parameters with respect to said evaluation of the second series of environmental, individual and/or clinical parameters. The method of the present invention thus allows to estimate the genetic risk of AMD more accurately than the methods known in the art.
    Type: Application
    Filed: September 29, 2017
    Publication date: August 1, 2019
    Inventors: Massimo SPATA, Anna Rita BLANCO, Sabrina CONOCI, Maria Cristina CURATOLO
  • Publication number: 20190233897
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: September 5, 2018
    Publication date: August 1, 2019
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • Publication number: 20190233898
    Abstract: Methods of deconvolving a feature profile of a physical system are provided herein. The present method may include: optimizing a regression between a) a feature profile of a first plurality of distinct components and b) a reference matrix of feature signatures for a second plurality of distinct components, wherein the feature profile is modeled as a linear combination of the reference matrix, and wherein the optimizing includes solving a set of regression coefficients of the regression, wherein the solution minimizes 1) a linear loss function and 2) an L2-norm penalty function; and estimating the fractional representation of one or more distinct components among the second plurality of distinct components present in the sample based on the set of regression coefficients. Systems and computer readable media for performing the subject methods are also provided.
    Type: Application
    Filed: December 19, 2018
    Publication date: August 1, 2019
    Inventors: Aaron M. Newman, Arash Ash Alizadeh
  • Publication number: 20190233899
    Abstract: The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 1, 2019
    Inventors: Nadia HARBECK, Ronald E. KATES, Manfred SCHMITT, John A, FOEKENS
  • Publication number: 20190233900
    Abstract: Compositions, methods, and uses of de novo pyrimidine synthesis pathway element, CAD, and optionally a second gene in a nucleotide excision repair pathway, POLD2 in determining a predicted survival rate, predicted responsiveness to a cisplatin-based chemotherapy of a patient diagnosed with bladder urothelial carcinoma are provided.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 1, 2019
    Inventors: Kevin B. Givechian, Chad Garner, Hermes J. Garban, Shahrooz Rabizadeh, Patrick Soon-Shiong
  • Publication number: 20190233901
    Abstract: An apoptosis regulatory gene is detected in an irradiated-thymic lymphoma cell by a method for detecting such an apoptosis regulatory gene in a low-dose-rate and low-level-irradiated thymic lymphoma cell of a mouse. This has an effect of revealing the function of an apoptosis regulatory gene by means of irradiation and providing a gene profile, by detecting an apoptosis regulatory gene detected in an irradiated-thymic lymphoma cell. The detected apoptosis regulatory gene is used to construct a gene profile that can assess the dose-response relationship of industrial and healthcare workers living in a low level-radiation environment. The detected apoptosis regulatory gene can be used as an index for evaluating the extent of cancer progression and the degree of treatment in patients with thymic lymphoma. The method for detecting such an apoptosis regulatory gene is used to prepare for the prepare a composition for diagnosing thymic lymphoma and a diagnostic kit.
    Type: Application
    Filed: September 8, 2016
    Publication date: August 1, 2019
    Inventors: Hee Sun KIM, Hoon CHOI, Kwang Hee YANG, Yun-Mi BAEK, Dong-Kwon KEUM, Hee Youn SHIM, Byulnim HWANG
  • Publication number: 20190233902
    Abstract: The present invention describes biomarkers that have been discovered to correlate with varied individual responses (e.g., efficacy, adverse effect, and other end points) to enzastaurin, in treating diseases such as, DLBCL, GBM, and other cancer types. The newly discovered biomarkers and others in linkage disequilibrium with them can be used in companion diagnostic tests which can help to predict drug responses and apply drugs only to those who will be benefited, or exclude those who might not be beneficial, by the treatment.
    Type: Application
    Filed: August 31, 2017
    Publication date: August 1, 2019
    Applicant: DENOVO BIOPHARMA LLC
    Inventors: Wen Luo, Hong Sun
  • Publication number: 20190233903
    Abstract: The present invention relates to a method of identifying targets for epigenetic reprogramming comprising detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC. The invention also provides for the use of differentially expressed genes to identify metastatic propensity in primary tumors, wherein the genes are selected from genes in the Tables herein, oxidative stress genes, EMT genes, immunological response genes, DNA repair genes, glucose metabolism genes, oxPPP genes, and PGD genes. Further, the invention provides a method for identifying agents or compounds to affect epigenomic changes, including inhibition of oxPPP comprising analyzing a sample from a subject before and after contacting with the agent or compound and determining the effect of the agent or compound on the epigenomic changes.
    Type: Application
    Filed: October 5, 2017
    Publication date: August 1, 2019
    Inventors: Oliver McDonald, Xin Li, Christine A. Iacobuzio-Donahue, Andrew P. Feinberg
  • Publication number: 20190233904
    Abstract: This invention relates in part to plant breeding and herbicide tolerant plants. This invention includes a novel aad-1 transformation event in corn plants comprising a polynucleotide sequence, as described herein, inserted into a specific site within the genome of a corn cell. In some embodiments, said event/polynucleotide sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect-inhibitory proteins. Additionally, the subject invention provides assays for detecting the presence of the subject event in a sample (or corn grain, for example). The assays can be based on the DNA sequence of the recombinant construct, inserted into the corn genome, and on the genomic sequences flanking the insertion site. Kits and conditions useful in conducting the assays are also provided.
    Type: Application
    Filed: February 19, 2019
    Publication date: August 1, 2019
    Inventors: Yunxing Cory CUI, Jill BRYAN, Donald MAUM, Greg GILLES, Terry WRIGHT, Jennifer HAMILTON, Nicole ARNOLD, Nathan VanOpdorp, Tina KAISER, Ning ZHOU
  • Publication number: 20190233905
    Abstract: The instant disclosure provides norovirus-binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Applicant: North Carolina State University
    Inventors: Lee-Ann Jaykus, Blanca Irene Escudero-Abarca, Matthew D. Moore, Helen Rawsthorne
  • Publication number: 20190233906
    Abstract: Novel strains of Staphylococcus aureus and uses thereof. The invention provides mutant strains of S. aureus devoid of all non-essential two-component signal systems (TCSs) and even the essential walKR system, the intermediate mutants devoid of a number of TCSs and their uses as research and biotechnological platform. The mutants devoid of all non-essential TCSs are viable, stable under laboratory growing conditions, genetically manageable and capable to express heterologous proteins. Having them allows individual analysis and targeting of each TCS, its individual complementation and obtaining information about the sensing systems that can be useful for biotechnological applications based or directed to S. aureus, such as the identification of novel antimicrobials.
    Type: Application
    Filed: August 26, 2015
    Publication date: August 1, 2019
    Inventors: Maite VILLANUEVA SAN MARTÍN, Begoña GARCÍA MARTÍNEZ, Jaione VALLE TURRILLAS, José R. PENADÉS CASANOVA, Miguel MARTÍ JIMÉNEZ, Alejandro TOLEDO ARANA, Iñigo LASA UZCUDUN
  • Publication number: 20190233907
    Abstract: The present invention provides a modified strain of the bacterium Lactococcus lactis obtainable by a method that comprises a step of fusion of two protoplasts from two Lactococcus lactis parental strains which, compared to the wild type strain of Lactococcus lactis from which they derive, show: (a) an increased ability to produce acetoin and/or 2,3-butanediol (2,3-BDO), and (b) a decreased ability to produce lactic acid, when cultured under aerobic conditions, and wherein the modified strain of Lactococcus lactis has an increased ability to produce 2,3-BDO of at least 20 times the amount produced by the wild type strain, an increased ability to produce acetoin of at least 20 times the amount produced by the wild type strain and a decreased ability to produce lactic acid of at least 10 times the amount produced by the wild type strain, when cultured under aerobic conditions. Also provided are methods to produce acetoin and 2,3-BDO.
    Type: Application
    Filed: July 18, 2017
    Publication date: August 1, 2019
    Inventors: Tomás RONCAL MARTÍNEZ, Susana CABALLERO ROMÁN, María Del Mar DÍAZ DE GUEREÑU ZABARTE, Inés RINCÓN ARROYO, Soraya PRIETO FERNÁNDEZ, José Ramón OCHOA GÓMEZ
  • Publication number: 20190233908
    Abstract: It relates to w-3 fatty acid desaturase for the synthesis of pufas from phytophthora parasitica, a plasmid containing the same, a recombinant microorganism containing the plasmid and its application. The invention also provides the use of the above ?-3 fatty acid desaturase in the biosynthesis of PUFAs, especially to catalyze C20:4?5,8,11,14 to C20:5?5,8,11,14,17 at normal temperature, with catalytic efficiency 65%. The recombinant strain reached 31.5% of the total fatty acid, and the conversion rate to AA was up to 77.
    Type: Application
    Filed: December 8, 2016
    Publication date: August 1, 2019
    Inventors: Haiqin CHEN, Yongquan CHEN, Wei CHEN, Tiantian MEI, Zhennan GU, Hao ZHANG
  • Publication number: 20190233909
    Abstract: A post-heating treatment device includes a detecting device for a height variation of a surface of the rail at every, predetermined pitch along a length direction of the rail, a control unit for defining a position of the rail to be a starting point of the welded section when the height variation detected by the detecting device at every predetermined pitch exceeds a predetermined threshold for the number of a predetermined times consecutively and defining a position of the rail to be an end point of the welded section when the height variation detected by the detecting device at every predetermined pitch is below the predetermined threshold for the number of the predetermined times consecutively, and a heating unit for heat treatment based on a position of the welded section detected by the detecting device. A post-heating treatment method using the post-heating treatment device is provided.
    Type: Application
    Filed: June 13, 2017
    Publication date: August 1, 2019
    Applicant: DAI-ICHI HIGH FREQUENCY CO., LTD.
    Inventors: Kenji SUGIYAMA, Nobuhiko MATSUMOTO, Ryuta HARADA
  • Publication number: 20190233910
    Abstract: Provided is an ultra-high-strength steel sheet having an excellent hole expandability and yield ratio, including, in terms of wt %: 0.05-0.2% of carbon (C); 2.0% or less of silicon (Si); 4.1-9.0% of manganese (Mn); 0.05% or less (excluding 0%) of phosphorus (P); 0.02% or less (excluding 0%) of sulfur (S); 0.5% or less (excluding 0%) of aluminum (Al); 0.02% or less (excluding 0%) of nitrogen (N); and a balance of iron (Fe) and other inevitable impurities, wherein the following Equation 1 is satisfied, and wherein microstructures includes, in volume percentage, 10-30% or retained austenite, 50% or more of annealed martensite, and 20% or less of other phases including alpha martensite and epsilon martensite, Equation 1: C/12+Ti/48+Nb/93+V/51+Mo/96?0.015.
    Type: Application
    Filed: October 24, 2017
    Publication date: August 1, 2019
    Inventors: Joo-Hyun RYU, Kyoo-Young LEE, Sea-Woong LEE, Won-Hwi LEE
  • Publication number: 20190233911
    Abstract: Provided is a heat treatment apparatus (1), including: a conveying device (10), which is configured to convey a rod-shaped workpiece (W) at a predetermined velocity along an axial direction of the workpiece (W); and a heating device (2) including a heating coil (3) configured to inductively heat the workpiece (W) being conveyed to a quenching temperature, wherein the heating coil (3) includes a first heating section (3A) and a second heating section (3B), which are coupled to each other in series along the axial direction of the workpiece (W), and is electrically connected to a single high-frequency power supply (4), and wherein a coil pitch (D2) of the second heating section (3B) arranged relatively on a front side in a conveying direction for the workpiece (W) is larger than a coil pitch (D1) of the first heating section (3A) arranged relatively on a rear side in the conveying direction.
    Type: Application
    Filed: May 26, 2017
    Publication date: August 1, 2019
    Applicant: NTN Corporation
    Inventors: Tsuneaki HIRAOKA, Yuuki TABUCHI, Shintaro SUZUKI
  • Publication number: 20190233912
    Abstract: A steel wire for a spring is formed of a steel containing from 0.5% by mass to 0.8% by mass of carbon, from 1.0% by mass to 2.5% by mass of silicon, from 0.2% by mass to 1.0% by mass of manganese, and from 0.5% by mass to 2.5% by mass of chromium, the balance being iron and incidental impurities. The steel has a tempered martensite structure. The hardness of a surface region that is a region within 10 ?m from an outer surface is from more than 0 HV to 50 HV higher than the hardness of a region other than the surface region.
    Type: Application
    Filed: June 8, 2017
    Publication date: August 1, 2019
    Inventors: Fuminori Okada, Kenichi Shimizu, Takafumi Uwano
  • Publication number: 20190233913
    Abstract: A 980 MPa-grade hot-rolled dual-phase steel and a manufacturing method therefor. The chemical components of the steel comprise, in percentage by weight, 0.10%-0.20% of C, 0.8%-2.0% of Si, 1.0%-2.0% of Mn, 0-0.02% of P, 0-0.005% of S, 0-0.003% of O, 0.02%-0.06% of Al, 0-0.006% of N, 0.01%-0.06% of Nb, 0.01%-0.05% of Ti, and the balance of Fe and inevitable impurities. In addition, the components need to meet the following relation: 0.05%?Nb+Ti?0.10. The microstructure of the steel is made of ferrite and martensite. The average grain size of the ferrite is 5-10 ?m, and the equivalent grain size of the martensite is 15-20 ?m.
    Type: Application
    Filed: June 19, 2017
    Publication date: August 1, 2019
    Applicant: BAOSHAN IRON & STEEL CO., LTD.
    Inventors: Huanrong WANG, Ana YANG, Jiansu ZHANG, Wei WANG
  • Publication number: 20190233914
    Abstract: Provided is a grain-oriented electrical steel sheet that has excellent magnetic properties and can be manufactured by secondary recrystallization orientation control using coil annealing with high productivity. A grain-oriented electrical steel sheet comprises a specific chemical composition, wherein an average value of a deviation angle (?2+?2)1/2 calculated from a deviation angle ? from ideal Goss orientation around an ND rotation axis and a deviation angle ? from ideal Goss orientation around a TD rotation axis is 5.0° or less, and an area ratio R? of crystal grains with ??0.50° is 20% or less.
    Type: Application
    Filed: September 21, 2017
    Publication date: August 1, 2019
    Applicant: JFE STEEL CORPORATION
    Inventors: Yasuyuki HAYAKAWA, Masanori TAKENAKA, Takeshi IMAMURA
  • Publication number: 20190233915
    Abstract: Disclosed are a quenched steel sheet and a method for manufacturing the same. The quenched steel sheet according to an aspect of the present invention contains, in terms of wt %, C: 0.05˜0.25%, Si: 0.5% or less (excluding 0), Mn: 0.1˜2.0%, P: 0.05% or less, S: 0.03% or less, the remainder Fe, and other unavoidable impurities, wherein a refined structure of the steel sheet comprises 90 volume % or more of martensite with a first hardness and martensite with a second hardness.
    Type: Application
    Filed: April 9, 2019
    Publication date: August 1, 2019
    Inventors: Kyong-Su PARK, Jae-Hoon JANG
  • Publication number: 20190233916
    Abstract: A post-heating treatment device performs a post-heating treatment for a welded section of a rail, after an induction heating coil is automatically disposed at a predetermined position based on the welded section. The device includes welded section detecting unit for detecting the position of a welded section on a rail, a first coil and a second coil that form an induction heating coil, first coil moving unit for moving the first coil to a position spaced apart from the rail at a predetermined distance, second coil moving unit for moving the second coil to a position separated from the rail at a predetermined distance, where the second coil is contacted to the first coil, clamping unit for pressing against the contact portion between the first coil and the second coil, and current applying unit for applying a predetermined current to the formed induction heating coil.
    Type: Application
    Filed: June 13, 2017
    Publication date: August 1, 2019
    Applicant: DAI-ICHI HIGH FREQUENCY CO., LTD.
    Inventors: Kenji SUGIYAMA, Nobuhiko MATSUMOTO, Ryuta HARADA
  • Publication number: 20190233917
    Abstract: Materials and methods for precious metal recovery are disclosed. Usable leaching solutions are preferably aqueous based and include appropriate materials in sufficient quantities to solubilize and stabilize precious metal. Such materials typically include phosphoric acid and an oxidant material. Some or all of the oxidant material can be, in some instances, generated in-situ. The leaching solution is typically contacted with a substrate having a target precious metal, thereby solubilizing precious metal to form a stable, pregnant solution. The precious metal can then be recovered from the pregnant solution. In some instances, components of the leaching solution can be regenerated and reused in subsequent leaching.
    Type: Application
    Filed: January 30, 2019
    Publication date: August 1, 2019
    Inventors: Duane Nelson, Ishwinder Singh Grewal, Mohammad Doostmohammadi, Hanif Jafari
  • Publication number: 20190233918
    Abstract: A set of improved substrates for plasmonic applications characterized by specific characteristics of surface plasmons, such as resonance frequencies, manifesting, notably, as a change of perceived color of said alloys, as well as alteration of surface plasmon energies and generation efficiency compared to the constituent elements. The disclosed compositions include alloys of gold, platinum, and palladium with other chemical elements, especially alkali metals (such as potassium, and rubidium), alkali earth metals (such as magnesium and barium) as well as transition metals (such as tin and zirconium).
    Type: Application
    Filed: January 30, 2019
    Publication date: August 1, 2019
    Inventors: Nikita Balashov Katz, Serghei Railean
  • Publication number: 20190233919
    Abstract: An electrode wire for use in an electrical discharge machining apparatus includes a metallic core and a layer of gamma phase brass disposed over the metallic core. Particles of beta phase brass are interspersed within the gamma phase brass layer. An oxide layer including zinc is disposed over the gamma phase brass layer.
    Type: Application
    Filed: October 6, 2017
    Publication date: August 1, 2019
    Inventor: DANDRIDGE TOMALIN
  • Publication number: 20190233920
    Abstract: The present invention is an aluminum alloy for low-pressure casting, and the aluminum alloy is made of an Al—Si—Cu—Mg alloy and contains: 8.0 to 12.6 mass % of Si; 1.0 to 2.5 mass % of Cu; 0.3 to 0.8 mass % of Mg; and 0.2 mass % or less of Ti, wherein the aluminum alloy further contains X mass % of P, Y mass % of Na, and Z mass % of Sr, with the balance including Al and inevitable impurities, and wherein a content of P, a content of Na, and a content of Sr satisfy all of the following relationships: 0.45Y+0.24Z+0.003?X?0.45Y+0.24Z+0.01; 0?Y?0.01; and 0?Z?0.03. The present invention ensures surface smoothness of the casted article by specifying the P content. This minimizes a surface segregation layer even in production of a casted article using a molten metal containing a eutectic structure modifier such as Na.
    Type: Application
    Filed: October 30, 2017
    Publication date: August 1, 2019
    Applicants: UACJ CORPORATION, UACJ Foundry & Forging Corporation
    Inventors: Akihiro Minagawa, Toshio Ushiyama
  • Publication number: 20190233921
    Abstract: The present invention is directed to aluminum-lithium alloys, specifically aluminum—copper—lithium—magnesium—manganese alloys. The aluminum-lithium alloy of the present invention comprises from 3.6 to 4.1 wt. % Cu, 0.8 to 1.05 wt. % Li, 0.6 to 1.0 wt. % Mg, 0.2 to 0.6 wt. % Mn, up to 0.12 wt. % Si, up to 0.15 wt. % Fe, from 0.03 to 0.16 wt. % of at least one grain structure control element selected from the group consisting of Zr, Sc, Cr, V, Hf, and other rare earth elements, up to 0.10 wt. % Ti, up to 0.15 wt. % incidental elements with the total of incidental elements not exceeding 0.35 wt. %, and the balance being aluminum. Preferably, Ag is not intentionally added and should not be more than 0.05 wt. % as a non-intentionally added element. Preferably, Zn is not intentionally added and should not be more than 0.2 wt. % as a non-intentionally added element. The amount of Cu in weight percent is at least equal to or higher than four times the amount of Li in weight percent.
    Type: Application
    Filed: February 1, 2018
    Publication date: August 1, 2019
    Applicant: Kaiser Aluminum Fabricated Products, LLC
    Inventors: Zhengdong Long, Philippe Lassince, Robert A. Matuska, Florence Andrea Baldwin, David J. Shoemaker, Ravi Rastogi, Roy A. Nash
  • Publication number: 20190233922
    Abstract: A cemented carbide comprising a first hard phase composed of tungsten carbide particles and a binder phase including Co, the cemented carbide having a ratio Nt/Na of 0.9 or more, where, in any surface or any cross section of the cemented carbide, a region in which there is a distance X of 5 nm or less between surfaces respectively of tungsten carbide particles adjacent to each other, the surfaces facing each other along a length L of 100 nm or more, is referred to as a WC/WC interface, and Na represents a total number of WC/WC interfaces and Nt represents a number of WC/WC interfaces having distance X of 1 nm or more and 5 nm or less and having therein an atomic percentage of Co higher than an average value of atomic percentages of Co in the tungsten carbide particles.
    Type: Application
    Filed: July 2, 2018
    Publication date: August 1, 2019
    Applicants: SUMITOMO ELECTRIC HARDMETAL CORP., SUMITOMO ELECTRIC HARDMETAL CORP.
    Inventors: Yasuki Kido, Daiji Tabayashi, Shinya Imamura
  • Publication number: 20190233923
    Abstract: A rod includes a first rod section occupying a predetermined region in a longitudinal direction, and a second rod section occupying a region different from the first rod section in the longitudinal direction. The first rod section has composition including A% by mass of cobalt, 0 to 1% by mass of chromium, 0 to 0.5% by mass of vanadium, and remainder of tungsten carbide and unavoidable impurities. The second rod section has composition including B% by mass of cobalt, 0 to 1% by mass of chromium, 0 to 0.5% by mass of vanadium, and remainder of tungsten carbide and unavoidable impurities. Contents of cobalt in the first rod section and the second rod section satisfy a relationship of 1% by mass?B<A?20% by mass. The second rod section has a length of 10 to 1000% with respect to the first rod section in the longitudinal direction.
    Type: Application
    Filed: February 28, 2017
    Publication date: August 1, 2019
    Inventors: Takahiro Yamakawa, Eiji Yamamoto, Hiroaki Gotou, Yoshimitsu Sawazono, Katsuya Uchino
  • Publication number: 20190233924
    Abstract: An alloy composition that includes aluminum (Al), titanium (Ti), vanadium (V), zirconium (Zr) and niobium (Nb), the alloy composition existing essentially as a single phase having a body-centered cubic crystal structure.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Applicant: The Boeing Company
    Inventors: Catherine J. Parrish, Carlos Angelo Nunes, Gilberto Carvalho Coelho, James D. Cotton, Nabil Chaia, Jose Mauro Moraes, JR.
  • Publication number: 20190233925
    Abstract: Rolled wire rod effectively suppressing fracturing at the time of cold forging and excellent in hydrogen embrittlement resistance after quenching and tempering following spheroidization annealing even without spheroidization annealing before cold forging or even if shortening the time period of spheroidization annealing is provided wherein it has a predetermined composition and wherein if the contents of Ti, N, and S (mass %) are respectively [Ti], [N], and [S], if [S]?0.0010, [Ti] is (4.5×[S]+3.4×[N]) or more and (0.008+3.4×[N]) or less, while if [S]?0.0010, [Ti] is (4.5×[S]+3.4×[N]) or more and (8.0×[S]+3.4×[N]) or less, the internal structure is a mixed structure of ferrite and pearlite with an area rate of a ferrite fraction of 40% or more, and a mean area of sulfides present in a range from a surface to a D/8 position is 6 ?m2 or less in the case of a diameter of D (mm) in a cross-section at a plane including the axial direction, and a mean aspect ratio of the sulfides is 5 or less.
    Type: Application
    Filed: July 5, 2017
    Publication date: August 1, 2019
    Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Naoki MATSUI, Yutaka NEISHI, Makoto KOSAKA
  • Publication number: 20190233926
    Abstract: A steel sheet has a specific chemical composition and has a structure represented by, by area ratio, ferrite: 5 to 95%, and bainite: 5 to 95%. When a region that is surrounded by a grain boundary having a misorientation of 15° or more and has a circle-equivalent diameter of 0.3 ?m or more is defined as a crystal grain, the proportion of crystal grains each having an intragranular misorientation of 5 to 14° to all crystal grains is 20 to 100% by area ratio. Hard crystal grains A in which precipitates or clusters with a maximum diameter of 8 nm or less are dispersed in the crystal grains with a number density of 1×1016 to 1×1019 pieces/cm3 and soft crystal grains B in which precipitates or clusters with a maximum diameter of 8 nm or less are dispersed in the crystal grains with a number density of 1×1015 pieces/cm3 or less are contained, and the volume % of the hard crystal grains A/(the volume % of the hard crystal grains A +the volume % of the soft crystal grains B) is 0.1 to 0.9.
    Type: Application
    Filed: August 4, 2017
    Publication date: August 1, 2019
    Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Kohichi SANO, Makoto UNO, Ryoichi NISHIYAMA, Yuji YAMAGUCHI, Natsuko SUGIURA, Masahiro NAKATA
  • Publication number: 20190233927
    Abstract: A steel for machine structural use is provided which is excellent in machinability, rusting characteristics, and hot ductility. The steel for machine structural use according to the present embodiment has a chemical composition which consists of, in mass %, C: 0.30 to 0.80%, Si: 0.01 to 0.80%, Mn: 0.20 to 2.00%, P: 0.030% or less, S: 0.010 to 0.100%, Pb: 0.010 to 0.100%, Al: 0.010 to 0.050%, N: 0.015% or less and O: 0.0005 to 0.0030%, with the balance being Fe and impurities, the chemical composition satisfying Formula (1). The total number of specific inclusions included in the steel which are any of MnS inclusions, Pb inclusions and composite inclusions containing MnS and Pb and which have an equivalent circular diameter of 5 ?m or more is 40 per mm2 or more. Mn/S?8.0??(1) Where, a content (mass %) of a corresponding element is substituted for each symbol of an element in Formula (1).
    Type: Application
    Filed: July 4, 2017
    Publication date: August 1, 2019
    Inventors: Masayuki Hashimura, Makoto Egashira, Takanori Iwahashi, Shouji Toudou
  • Publication number: 20190233928
    Abstract: A method for providing a Zn—Al—Mg coating on a steel strip using a hot dip coating process with a coating bath, wherein the thickness of the coating is controlled using gas knifes above the coating bath. Specific amounts of Mg and Al are chosen, in a relationship wherein the amount of Al is higher than the amount of Mg. Also provided is a steel strip having a Zn—Al—Mg coating provided by hot dip coating.
    Type: Application
    Filed: July 20, 2017
    Publication date: August 1, 2019
    Applicant: TATA STEEL IJMUIDEN B.V.
    Inventors: Jaap Peter VAN EENENNAAM, Shangping CHEN, Edgar Matthijs TOOSE
  • Publication number: 20190233929
    Abstract: A thermal barrier coating film includes a bond coat layer that is a metallic bond layer formed on a base material; a topcoat layer that is a ceramic-containing layer formed on the bond coat layer; and at least one of a protective layer and a protective substance. The protective layer is formed on the topcoat layer and mainly containing SrSO4. The protective substance is provided in the interior of a plurality of void spaces included in the topcoat layer and mainly contains SrSO4.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 1, 2019
    Inventors: Taiji TORIGOE, Yoshifumi OKAJIMA, Daisuke KUDO, Hiroyuki MITSUI, Masahiko MEGA, Shuji TANIGAWA
  • Publication number: 20190233930
    Abstract: An embodiment of the present disclosure provides a vapor deposition device and a vapor deposition method thereof. The vapor deposition device comprises an adjustable magnet array. The adjustable magnet array comprises m magnet blocks, wherein a magnetization direction of at least one of the magnet blocks is adjustable. The vapor deposition device is used to prepare a film.
    Type: Application
    Filed: April 23, 2018
    Publication date: August 1, 2019
    Inventors: Jian XU, Yaoyang LIU
  • Publication number: 20190233931
    Abstract: The fine metal mask provided in the present disclosure includes at least one mask pattern portion, and at least one protective portion that is disposed on and connected with at least one side edge of the at least one mask pattern portion, wherein a thickness of the at least one protective portion is less than a thickness of the at least one mask pattern portion.
    Type: Application
    Filed: December 28, 2018
    Publication date: August 1, 2019
    Inventors: Bin ZHANG, Xinxing WANG, Tingting ZHOU, Xuefei SUN, Weijie WANG, Haibin ZHU
  • Publication number: 20190233932
    Abstract: A mask assembly for thin film deposition and a method of manufacturing the same. The mask assembly includes a glass mask having a first surface and a second surface opposite the first surface, a first metal layer patterned above the first surface of the glass mask, and a second metal layer patterned below the second surface of the glass mask. A plurality of deposition areas are arranged on the glass mask, and a plurality of deposition pattern portions each having a plurality of slits are patterned in the plurality of deposition areas.
    Type: Application
    Filed: March 14, 2019
    Publication date: August 1, 2019
    Inventor: Sangmin YI
  • Publication number: 20190233933
    Abstract: The present disclosure relates to multilayer constructs for producing metabolite strips. The multilayer constructs include a substrate layer having a top surface and a bottom surface, a thin film metal conductor layer formed on the top surface of the substrate layer and configured to act as an electrode, and a Transparent Conductive Oxide (TCO) protective layer deposited on top of the metal conductor layer. The metabolic strips can be used, along with various measuring devices, for determining the presence of certain analytes in a specimen and for various like applications.
    Type: Application
    Filed: February 5, 2019
    Publication date: August 1, 2019
    Inventors: Kevin V. Goodwin, Robert R. Newton, Peter J. Asiello, Ian S. Tribick, Jerome Farquharson
  • Publication number: 20190233934
    Abstract: A steel sheet is provided with a coating having at least one layer of zinc and a top layer of paint applied by cataphoresis. The zinc layer is deposited by a jet vapor deposition process in a deposition chamber maintained at a pressure between 6·10?2 mbar and 2·10?1 mbar. A fabrication method and an installation are also provided.
    Type: Application
    Filed: April 11, 2019
    Publication date: August 1, 2019
    Inventors: Daniel Chaleix, Daniel Jacques, Sergio Pace, Eric Silberberg, Bruno Schmitz, Xavier Vanden Eynde
  • Publication number: 20190233935
    Abstract: A method of forming a copper manganese sputtering target including subjecting a copper manganese billet to a first unidirectional forging step, heating the copper manganese billet to a temperature from about 650° C. to about 750° C., subjecting the copper manganese billet to a second unidirectional forging step, and heating the copper manganese billet to a temperature from about 500° C. to about 650° C. to form a copper alloy.
    Type: Application
    Filed: January 14, 2019
    Publication date: August 1, 2019
    Inventors: Stephane Ferrasse, Frank C. Alford, Ira G. Nolander, Erik L. Turner, Patrick Underwood
  • Publication number: 20190233936
    Abstract: Device and method for producing defined properties of gradient layers in a system of multilayered coatings in sputtering installations with the following features: a) a pair of cathodes arranged in a common process chamber and consisting of a first cathode body and a second cathode body is supplied with direct current by means of a common power supply, wherein, before entering the process chamber, the direct current is converted into a series of pulses comprising alternating positive and negative pulses with interpulse periods in between, b) an arrangement for controlling the length of the individual pulses and the duration of the respective interpulse periods.
    Type: Application
    Filed: October 18, 2017
    Publication date: August 1, 2019
    Applicant: GRENZEBACH MASCHINENBAU GMBH
    Inventors: Joerg FIUKOWSKI, Gerd KLEIDEITER
  • Publication number: 20190233937
    Abstract: A loading jig and an evaporator are provided. The loading jig includes a body and at least one elastic membrane. The body has a plate-like structure and is sandwiched between the bearing platform and the plurality of clamping blocks. Said at least one elastic membrane is respectively disposed between at least one clamping block and a bottom of the body. The elastic membrane is externally connected to a signal converter. The pressure applied by the clamping block may be measured through the elastic membrane when the clamping block is pressed against the bottom of the body, and then the measured pressure signal is transmitted to the signal converter to be converted into a pressure value.
    Type: Application
    Filed: December 11, 2018
    Publication date: August 1, 2019
    Inventor: Liwei GUAN