Patents Issued in August 15, 2019
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Publication number: 20190248696Abstract: Annealing treatments for modified titania-silica glasses and the glasses produced by the annealing treatments. The annealing treatments include an isothermal hold that facilitates equalization of non-uniformities in fictive temperature caused by non-uniformities in modifier concentration in the glasses. The annealing treatments may also include heating the glass to a higher temperature following the isothermal hold and holding the glass at that temperature for several hours. Glasses produced by the annealing treatments exhibit high spatial uniformity of CTE, CTE slope, and fictive temperature, including in the presence of a spatially non-uniform concentration of modifier.Type: ApplicationFiled: April 22, 2019Publication date: August 15, 2019Inventors: Sezhian Annamalai, Carlos Alberto Duran, Kenneth Edward Hrdina, William Rogers Rosch
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Publication number: 20190248697Abstract: The present invention relates to an alkali-free glass and a method for producing the same. More specifically, the present invention relates to an alkali-free glass suitable as a glass for substrates of various displays such as liquid crystal display, and a method for producing the same. According to the present invention, an alkali-free glass suitable as a glass for display substrates, in which inclusion of bubbles is greatly reduced by virtue of containing a refining agent and suppressing the stirring reboil, is obtained.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Applicant: AGC Inc.Inventors: Hirofumi TOKUNAGA, Kazutaka Ono, Motoyuki Hirose
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Publication number: 20190248698Abstract: The present invention provides a low-alkali or alkali-free glass for laser processing, the glass reducing occurrence of laser irradiation-induced cracks and allowing formation of circular through holes. The present invention relates to the glass for laser processing, the glass having a glass composition including, in mol %: 45.0%?SiO2?70.0%; 2.0%?B2O3?20.0%; 3.0%?Al2O3?20.0%; 0%?ZnO?9.0%; and (I) 0.1%?CuO?2.0% and 0%?TiO2?15.0%; or (II) 0.1%?TiO2<5.0% and 0%?CuO<0.1%, wherein, in the case of (II), a metal oxide serving as a coloring component is further included, a relationship of 0?Li2O+Na2O+K2O<2.0% is satisfied, either of principal surfaces of the glass has a layer containing fine particles, and the fine particles have an average particle diameter of 10 nm or more and less than 1.0 ?m.Type: ApplicationFiled: June 15, 2017Publication date: August 15, 2019Inventors: Keiji TSUNETOMO, Haruhiko MAMADA, Teruhide INOUE
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Publication number: 20190248699Abstract: Provided is an optical cap component that can give good sensitivity to an infrared light absorption-based optical gas sensor. An optical cap component includes: a window member formed of a lens-shaped infrared transmitting glass; and a cap member including a cylindrical sidewall portion having openings on both a distal end side and a base end side, wherein the window member is fixed to cover the opening on the distal end side of the cap member.Type: ApplicationFiled: October 5, 2017Publication date: August 15, 2019Inventors: Yoshimasa MATSUSHITA, Fumio SATO
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Publication number: 20190248700Abstract: A low-emissivity (low-E) coating on a substrate (e.g., glass substrate) includes at least first and second infrared (IR) reflecting layers (e.g., silver based layers) that are spaced apart by contact layers (e.g., NiCr based layers), a layer comprising silicon nitride, and an absorber layer of or including a material such as niobium zirconium which may be oxided and/or nitrided. The absorber layer is designed to allow the coated article to realize glass side reflective (equivalent to exterior reflective in an IG window unit when the coating is on surface #2 of the IG unit) grey color. In certain example embodiments, the coated article (monolithic form and/or in IG window unit form) has a low visible transmission (e.g., from 20-45%, more preferably from 22-39%, and most preferably from 25-37%). In certain example embodiments, the coated article may be heat treated (e.g., thermally tempered and/or heat bent).Type: ApplicationFiled: October 18, 2016Publication date: August 15, 2019Applicants: GUARDIAN GLASS, LLC, GUARDIAN GLASS HOLDING S.P.C.Inventors: ARITRA BISWAS, BRENT BOYCE, ALLEN CHU, PHILIP J. LINGLE, KENNETH LORD, MUNISWAMI NAIDU, KRISHNA SWAMYNAIDU
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Publication number: 20190248701Abstract: A coated article includes a substrate, a functional layer over at least a portion of the substrate, and a protective coating over at least a portion of the functional layer, wherein an uppermost layer of the functional layer is a metal oxide layer, and wherein the protective coating comprises a metal nitride layer and a metal oxynitride layer that is disposed between and in contact with at least part of the metal nitride layer and the metal oxide layer of the functional layer.Type: ApplicationFiled: February 13, 2019Publication date: August 15, 2019Applicant: VITRO FLAT GLASS LLCInventors: Ashtosh GANJOO, Sudarshan NARAYANAN, James J. FINLEY, Paul V. MEDWICK
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Publication number: 20190248702Abstract: A method for producing a glass article is provided. The method for producing a glass article, the method including preparing a glass to be processed, the glass comprising a glass bulk and a low-refractive surface layer disposed on the glass bulk, and etching away the low-refractive surface layer to form an etched glass, wherein the etching away the low-refractive surface layer comprises: cleaning the low-refractive surface layer with an acid solution; and cleaning the low-refractive surface layer with a base solution after the cleaning it with the acid solution.Type: ApplicationFiled: October 16, 2018Publication date: August 15, 2019Inventors: Hoi Kwan LEE, Sung Hoon KIM, Seung Ho KIM, Sook Kyung YOU, An Na RYU, Jeong Seok LEE
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Publication number: 20190248703Abstract: A glass article having a low level of grainy appearance that can appear to have a shift in the pattern of the grains with changing viewing angle of a display, or “sparkle.” The glass article—which, in some embodiments, is a transparent glass sheet—has small-angle-scattering properties and/or distinctness-of-reflected-image (DOI), leading to improved viewability in display applications, especially under high ambient lighting conditions. In some embodiments, the antiglare surface of the glass sheet is an etched surface, with no foreign coating present on the antiglare surface.Type: ApplicationFiled: December 11, 2018Publication date: August 15, 2019Inventors: Jacques Gollier, Shandon Dee Hart, Kelvin Nguyen, Alan Thomas Stephens, II, James Andrew West, Lu Zhang
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Publication number: 20190248704Abstract: A simulated concrete mixture combines aggregate, sand, mortar clay, and additive. The mixture is hydrated with enough water or a hydrating solution to create a simulated concrete material having a desired slump. Useful aggregates include any type of aggregate used as a base for concretes, and useful additives include soaps, detergents, surfactants, and flocculants. The material can be refreshed with water or a refresher solution. The hydrating solution and refreshing solution are solution of water and additive. The simulated concrete material can be manipulated until its consistency becomes unworkable, after which it can be refreshed with water or refresher solution.Type: ApplicationFiled: February 12, 2019Publication date: August 15, 2019Inventor: Frank Mikowychok
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Publication number: 20190248705Abstract: Bitumen pellets including a core and a coating layer, in which: the core includes at least one bitumen base, and the coating layer includes at least one fumed silica compound. Process for manufacturing bitumen pellets and also their use as road binder, in particular for the manufacture of bitumen mixes. Process for manufacturing bitumen mixes from bitumen pellets and also a process for transporting and/or storing and/or handling bitumen pellets.Type: ApplicationFiled: September 5, 2017Publication date: August 15, 2019Applicant: TOTAL MARKETING SERVICESInventor: Mouhamad MOUAZEN
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Publication number: 20190248706Abstract: Provided are a magnesia carbon brick which does not include graphite yet has excellent spalling and corrosion resistances, and a method for producing thereof. The brick is obtained by adding an organic binder to a refractory raw material mixture followed by kneading, molding, and heat-treating, wherein the mixture includes total 0.1 to 2.0 mass % of pitch and/or carbon black, total 0.1 to 1.0 mass % of aluminum and/or aluminum alloy, 3.0 to 10.0 mass % of magnesia having particle diameter of less than 0.075 mm, and 87.0 to 96.0 mass % of magnesia having particle diameter of 0.075 to 5 mm; and a mass ratio of magnesia having particle diameter of 1 to 5 mm to that of 0.075 to 1 mm is 1.66 to 2.34; graphite is not included therein; and an apparent porosity thereof after heat-treatment under reductive atmosphere at 1400° C. for 3 hours is 8.0% or less.Type: ApplicationFiled: October 16, 2017Publication date: August 15, 2019Applicants: KROSAKIHARIMA CORPORATION, NIPPON STEEL CORPORATIONInventors: Yuya TOMITA, Masato TANAKA, Shigeto SAWAI
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Publication number: 20190248707Abstract: The invention relates to a process for making a ceramic body that comprises providing particles of a metal salt precursor material wetted by a liquid medium. The particles are characterized by a grain size of below 600 nm, and the precursor material has a solubility in the liquid medium of at least 10?5 mol/L. A pressure of ?100 MPa is applied at a temperature of below 100° C., rendering a material of high theoretical density values previously unattainable at low temperatures. The invention further relates to a calcium carbonate ceramic material of the vaterite isomorph having a density of the material ?1.76 g/cm3 and a Modulus of rupture ?30 MPa, and to a calcium phosphate ceramic material consisting of the monetite isomorph with ?2.5 g/cm3 density and a Modulus of rupture ?18 MPa.Type: ApplicationFiled: July 4, 2017Publication date: August 15, 2019Applicant: ETH ZÜRICHInventors: Florian BOUVILLE, Andre R. STUDART
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Publication number: 20190248708Abstract: A ferroelectric polymer electrocaloric nanowire array and a preparation method thereof, in which the ferroelectric polymer electrocaloric material is formed by a polyvinylidene fluoride (PVDF)-based ferroelectric polymer electrocaloric nanowire array embedded in a porous anodic alumimum oxide (AAO) template. The PVDF-based ferroelectric polymer electrocaloric material is controlled to form a nanowire array embedded in the porous AAO template, and through adopting of a solution infiltration method to prepare the ferroelectric polymer electrocaloric nanowire array in the porous AAO template and improvement of the key morphology, structure, internal microscopic connection construction of the ferroelectric polymer, problems, such as low electrocaloric strength of the ferroelectric polymer, difficult heat conduction in the electrocaloric material and low refrigerating power density of the electrocaloric device in the prior art, can be effectively solved.Type: ApplicationFiled: May 7, 2018Publication date: August 15, 2019Applicant: Huazhong University of Science and TechnologyInventors: Guangzu ZHANG, Zhaoyao HU, Lingxi WENG, Shenglin JIANG, Mingyu LI
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Publication number: 20190248709Abstract: The present invention is directed to a porous pre-densified CeO2-stabilized ZrO2 ceramic having a density of 50.0 to 95.0%, relative to the theoretical density of zirconia, and an open porosity of 5 to 50% as well as to a densified CeO2-stabilized ZrO2 ceramic having a density of 97.0 to 100.0%, relative to the theoretical density of zirconia, and wherein the grains of the ceramic have an average grain size of 50 to 1000 nm, methods for the preparation of the pre-densified and densified ceramics and their use for the manufacture of dental restorations.Type: ApplicationFiled: April 25, 2019Publication date: August 15, 2019Inventors: Christian Ritzberger, Frank Rothbrust, Marcel Schweiger, Nicolas Courtois, Jérôme Chevalier, Helen Reveron, Wolfram Höland, Volker Rheinberger
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Publication number: 20190248710Abstract: The present invention is to provide an economical and efficient method of reducing drying shrinkage of a cement-based hardened body without requiring the cost and/or the labor and time. A cement-based hardened body is impregnated with a solution containing urea or a solution containing sulfate together with urea. An impregnation treatment may be by a method of coating or spraying the cement-based hardened body with the solution, or alternatively, immersing the cement-based hardened body in the solution containing both urea and sulfate for a predetermined period of time. The solution containing both urea and sulfate may be a solution prepared simply by dissolving both urea and sulfate in water.Type: ApplicationFiled: October 2, 2017Publication date: August 15, 2019Inventors: HIROMI FUJIWARA, SHINICHI TAKEMOTO, YOSHIKATSU SASAKI
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Publication number: 20190248711Abstract: A liquid fertilizer is produced from off-gassed ammonia resulting from the processing of animal waste materials, particular animal manure. The vaporized ammonia is generated primarily by heating the animal waste materials and capturing the resulting vapors and particulate materials. The ammonia vapors and particles are removed from the gas stream through a scrubbing operation, which creates an ammonium-enriched liquid stream that can be concentrated into an organic fertilizer having a high-nitrogen content.Type: ApplicationFiled: February 15, 2019Publication date: August 15, 2019Inventors: Daniel T. Hazen, John S. Martin, Lloyd Patrick Burchard, William P. Love
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Publication number: 20190248712Abstract: The present development is a method for producing a high concentration free amino acid soy hydrolysate composition and a method for using the resulting hydrolysate composition. The high concentration free amino acid soy hydrolysate is used to enhance the microbe population found in soil and wastewater. The enhanced microbe population can promote plant growth, particularly for use in brownfields and similar reclamation sites or on turf grasses, and can promote the digestion of sewage solids.Type: ApplicationFiled: August 21, 2017Publication date: August 15, 2019Applicant: Nachurs Alpine Solutions, Corp.Inventor: Franklin O. Kroh
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Publication number: 20190248713Abstract: A foliar fertilizer composition rich in oligosaccharides and phytohormones obtained from the sequential hydrolysis of a soybean paste, with a proteolytic enzyme with cysteine active site and a cellulase isolated from Trichoderma harzianum.Type: ApplicationFiled: June 23, 2016Publication date: August 15, 2019Applicant: AZUL NATURAL S.A. DE C.V.Inventors: José Manuel NARVÁEZ MASTACHE, Rosa Laura ANDRADE MELCHOR
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Publication number: 20190248714Abstract: The present invention comprises one or more organic solvents that create a non-aqueous organo solvent delivery system, (NOSDS), and one or more Organo Polycarboxylate functionalities, OPCF, that results in a stable, non-aqueous solution that can easily, safely, evenly and economically coat nitrogen source granules and/or be added to a mobile liquid form of a nitrogen source such as an aqueous dispersion, pressurized ammonia gas or molten urea and/or molten modified urea. Using these solvents provides more flexibility for nitrogen source manufacturers to produce nitrogen sources designed for a particular soil or plant. The liquid solutions are comprised of NOSDS and OPCFs and one or more of a) nitrification inhibitors, b) urease inhibitors, c) pesticides, d) fungicides, e) herbicides, f) insecticides and g) micronutrients.Type: ApplicationFiled: February 11, 2019Publication date: August 15, 2019Inventors: Gary David McKnight, Randall Linwood Rayborn
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Publication number: 20190248715Abstract: The present invention relates to increasing and/or maintaining nitrogen content in soil by administration of granular or powdered nitrification inhibitors coated with urease inhibitors. In one embodiment, urease inhibitors are dispersed in an improved organo liquid delivery system at concentration levels of 50-90%. In another embodiment, urease inhibitors were applied in a non-aqueous, organo liquid delivery system coating solid nitrification inhibitors utilizing simple blending equipment at temperatures of 20°-70° C. Another embodiment discloses a dry, flowable additive containing a nitrification inhibitor coated with a urease inhibitor which can be administered directly to the soil, to a dry natural and/or a manmade fertilizer or to a liquid fertilizer which provides for the reduction of nitrogen loss from the soil.Type: ApplicationFiled: October 15, 2018Publication date: August 15, 2019Inventors: Gary David McKnight, Randall Linwood Rayborn
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Publication number: 20190248716Abstract: Processes and associated reaction systems for the oxidative dehydrogenation of ethane are provided. In particular, a process is provided that comprises supplying a feed gas comprising ethane and oxygen to a multitubular fixed-bed reactor, allowing the ethane and oxygen to react in the presence of an oxidative dehydrogenation catalyst to yield a reactor effluent comprising ethylene; supplying a coolant to an upstream region of an interior shell space of the reactor in a flow pattern that is counter-current with the flow of the feed gas; and withdrawing the coolant from the upstream region and supplying at least a portion of the coolant withdrawn from the upstream region to the downstream region in a flow pattern that is co-current with the flow of the feed gas.Type: ApplicationFiled: July 24, 2017Publication date: August 15, 2019Inventors: Ronald Jan SCHOONEBEEK, Guss VAN ROSSUM, Alouisius Nicolaas Renée BOS
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Publication number: 20190248717Abstract: A method of producing and separating an alkene, such as ethylene, from an alkane, such as ethane. The method comprises subjecting a feedstock comprising ethane to oxidative dehydrogenation to produce an ethylene stream. The ethylene stream is passed through a membrane separation unit to separate the ethylene from unreacted ethane in the ethylene stream. The ethylene is recovered from the membrane separation unit. A system configured to produce ethylene is also disclosed. The system comprises at least one ODH reactor, a heat management unit coupled to the at least one ODH reactor, and at least one membrane separation unit comprising at least one membrane. The ODH reactor is configured to convert ethane to ethylene. The heat management unit is configured to reduce a temperature of the ethylene. The at least one membrane is configured to separate the ethylene from unreacted ethane.Type: ApplicationFiled: November 3, 2017Publication date: August 15, 2019Inventors: Anne M. Gaffney, Daniel M. Ginosar, Olivia M. Mason, Gennaro J. Maffia
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Publication number: 20190248718Abstract: The present invention relates to an improved amine based additive composition for control and inhibition of polymerization of aromatic vinyl monomers, particularly of styrene comprising one or more quinone methide compounds, one or more phenolic compounds and further comprising at least one aliphatic tertiary amine containing —OH group in the alkyl chain. In one embodiment, the present invention also relates to method of use of presently provided composition. In another embodiment, the present invention also relates to method of controlling and inhibiting polymerization of aromatic vinyl monomers, particularly of styrene by employing presently provided composition. In still another embodiment, the present invention also relates to method of preparation of presently provided composition.Type: ApplicationFiled: February 9, 2017Publication date: August 15, 2019Inventor: Mahesh SUBRAMANIYAM
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Publication number: 20190248719Abstract: Disclosed is a process for the preparation of cis-1,1,1,4,4,4-hexafluoro-2-butene comprising contacting 1,1,1-trifluorotrichloroethane with hydrogen in the presence of a catalyst comprising ruthenium to produce a product mixture comprising 1316mxx, recovering said 1316mxx as a mixture of Z- and E-isomers, contacting said 1316mxx with hydrogen, in the presence of a catalyst selected from the group consisting of copper on carbon, nickel on carbon, copper and nickel on carbon and copper and palladium on carbon, to produce a second product mixture, comprising E- or Z—CFC-1326mxz, and subjecting said second product mixture to a separation step to provide E- or Z-1326mxz.Type: ApplicationFiled: January 30, 2019Publication date: August 15, 2019Inventors: IVAN SERGEYEVICH BALDYCHEV, STEPHAN M. BRANDSTADTER, PATRICIA CHEUNG, MARIO JOSEPH NAPPA
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Publication number: 20190248720Abstract: The present invention relates to a process for etherification of mixed olefinic light naphtha boiling in the range of C5-90° C. cut with simultaneous minimization of unreacted methanol concentration in the product. The etherification of mixed olefinic light naphtha produces the high octane blending component which can be blended directly in the gasoline pool without any recovery of the feed oxygenates like methanol, ethanol etc. which conventionally uses energy intensive separation processes.Type: ApplicationFiled: December 31, 2018Publication date: August 15, 2019Applicant: INDIAN OIL CORPORATION LIMITEDInventors: Saravanan SUBRAMANI, Prosenjit MAJI, Reshmi MANNA, Pushkar VARSHNEY, Latoor Lal SAROYA, Kamlesh GUPTA, Dheer SINGH, Debasis BHATTACHARYYA, Sanjiv Kumar MAZUMDAR, Sankara Sri Venkata RAMAKUMAR
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Publication number: 20190248721Abstract: This invention relates to a process for preparing a calixarene compound by reacting a phenolic compound and an aldehyde in the presence of at least one nitrogen-containing base as a catalyst to form the calixarene compound. The invention also relates to processes for high-yield, high solid-content production of a calixarene compound, with high selectivity toward a high-purity calix[8]arene compound, without carrying out a recrystallization step.Type: ApplicationFiled: February 8, 2019Publication date: August 15, 2019Inventors: Cornelius HAASE, Ricky BIITTIG, Allyson STAATS, Philip David ATWOOD, Jim WEBB, Kelly CHICHAK
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Publication number: 20190248722Abstract: This invention relates to a one-pot synthesis of a high-purity calix[4]arene compound by reacting a phenolic compound and an aldehyde in the presence of at least one nitrogen-containing base as a catalyst to form the calix[8]arene compound, and cleaving the calix[8]arene compound into a high-purity calix[4]arene compound, directly, without carrying out a purification step before the cleaving step. The invention also relates to an improved conversion of a calix[8]arene compound to a calix[4]arene compound, by cleaving a calix[8]arene compound in a glycol ether solvent having a boiling point of at least about 200° C., to result in a high-purity calix[4]arene compound, without using an antisolvent.Type: ApplicationFiled: February 8, 2019Publication date: August 15, 2019Inventors: Cornelius HAASE, Jeff HISCOCK, Philip David ATWOOD
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Publication number: 20190248723Abstract: A method for processing lignin may comprise flowing a lignin composition comprising a lignin polymer and a solvent through a reaction chamber of a continuous flow reactor, the lignin polymer comprising hydroxycinnamic groups bound to a polymeric backbone; flowing ozone through the reaction chamber containing the lignin composition under conditions to maximize oxidative cleavage of the hydroxycinnamic groups to produce one or more types of aromatic monomers while minimizing oxidative cleavage of the polymeric backbone; and collecting the one or more types of aromatic monomers, e.g., by a size-selective membrane separation device.Type: ApplicationFiled: July 13, 2017Publication date: August 15, 2019Applicant: University of KansasInventors: Bala SUBRAMANIAM, Andrew M. DANBY, Michael D. LUNDIN
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Publication number: 20190248724Abstract: A process for the production of glycolic acid or a derivative thereof comprises: reacting formaldehyde with carbon monoxide and water in a carbonylation reactor in the presence of a sulfurcatalyst, said reactor operating under suitable conditions, such that glycolic acid is formed; recovering a first product stream comprising glycolic acid, impurities and a sulfur species in the carbonylation reactor; passing the first product stream to an esterification reactor where it is subjected to esterification to form an alkylglycolate and wherein the esterification is catalysed by the sulfur species recovered in the first product stream; recovering a second product stream comprising the alkylglycolate, sulfur species and impurities from the esterification reactor; separating the sulfur species from the second product stream and recycling it to the carbonylation reactor in step (a) to form a sulphur depleted second product stream; separating the alkylglycolate from the sulphur depleted second product stream in a distiType: ApplicationFiled: September 15, 2017Publication date: August 15, 2019Inventors: Dena ROBERTS, David John WATSON, John SWINNEY
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Publication number: 20190248725Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.Type: ApplicationFiled: April 29, 2019Publication date: August 15, 2019Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
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Publication number: 20190248726Abstract: The present disclosure provides a method for isolating a long chain dicarboxylic acid from fermentation broth containing microbial cells. Also provided is a substantially pure long chain dicarboxylic acid isolated by the method.Type: ApplicationFiled: July 11, 2016Publication date: August 15, 2019Applicants: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.Inventors: Bingbing QIN, Yufeng YANG, Xiucai LIU
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Publication number: 20190248727Abstract: The invention relates to a method for separating formic acid from a reaction mixture by means of extraction, wherein, in addition to the formic acid, the reaction mixture comprises a polyoxometalate ion of general formula [PMoxVyO40]n? as a catalyst and a solvent that dissolves the catalyst, wherein 6?x?11, 1?y?6, x+y=12 and 3<n<10, wherein n, x, and y are each a whole number, wherein the separation occurs via extraction by means of a polar organic extraction agent which extracts the formic acid and the catalyst and which is N—(N-Hexadecyl)formamide, N-di-n-acetamide or an N,N-dialkylcarboxamide, wherein the N,N-dialkylcarboxamide forms a phase boundary between the solvent and the extraction agent during mixing with the solvent, wherein the extraction agent is one which, for extraction of the catalyst contained in water at a concentration of 1.5 wt. %, has a catalyst distribution coefficient at 40° C.Type: ApplicationFiled: July 17, 2017Publication date: August 15, 2019Applicant: OXFA GMBHInventors: Hermann Wolf JBACH, Florian KOHLER, Matthias SCHMIDT, Gunthard SCHOLZ, Martin DIRAUF
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Publication number: 20190248728Abstract: Preparation of 2,5,6-trihydroxy-3-hexenoic acid and 2,5-dihydroxy-3-pentenoic acid and esters thereof from C6 and C5 sugars in the presence of a Lewis Acid material, wherein the yield of the 2,5,6-trihydroxy-3-hexenoic acid or 2,5-dihydroxy-3-pentenoic acid or esters thereof exceeds 15%. The process including the steps of contacting a saccharide composition including one or more C6 and/or C5 saccharide units with a Lewis Acid material; and recovering 2,5,6-trihydroxy-3-hexenoic acid and/or 2,5-dihydroxy-3-pentenoic acid or the esters thereof.Type: ApplicationFiled: April 25, 2019Publication date: August 15, 2019Applicant: HALDOR TOPSØE A/SInventors: Esben TAARNING, lrantzu SADABA ZUBIRI, Sebastian MEIER
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Publication number: 20190248729Abstract: This invention relates to a stilbene derivative and a method of preparing the same, and more particularly to a novel stilbene derivative for inhibiting the function of cyclophilin, which is effective at the prevention of cyclophilin-related diseases or at the treatment of symptoms of such diseases, and to a method of preparing the same.Type: ApplicationFiled: September 29, 2017Publication date: August 15, 2019Inventors: Min-Kyung LEE, Jin-Kak LEE, Won-Seok HAN
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Publication number: 20190248730Abstract: Aspects of the present disclosure include fatty acid ?-hydroxyester compounds (e.g., fatty acid esters of ?-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid ?-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.Type: ApplicationFiled: June 2, 2017Publication date: August 15, 2019Applicants: THE J. DAVID GLADSTONE INSTITUTES, ITHACA COLLEGE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ITHACA COLLEGEInventors: Eric Verdin, Scott Michael Ulrich, John C. Newman
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Publication number: 20190248731Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C3-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.Type: ApplicationFiled: May 31, 2018Publication date: August 15, 2019Inventors: Vladimir MALININ, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
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Publication number: 20190248732Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.Type: ApplicationFiled: April 22, 2019Publication date: August 15, 2019Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
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Publication number: 20190248733Abstract: An ester of beta-hydroxy butyrate or derivate esterfied with an amino acid or fatty acid used as an oral supplement.Type: ApplicationFiled: February 14, 2019Publication date: August 15, 2019Inventors: Benjamin Bikman, David Michaelis, David Thomson
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Publication number: 20190248734Abstract: The present invention relates to crystalline modification of (3,4-dichlorophenyl)propanamide (propanil), to a process for the preparation of the same, to pesticidal mixtures and compositions comprising the crystalline modification of (3,4-dichlorophenyl)propanamide and to a method of combating weeds using said mixtures and compositions.Type: ApplicationFiled: April 26, 2019Publication date: August 15, 2019Inventors: Birja SHANKER, Jaidev Rajnikant SHROFF, Vikram Rajnikant SHROFF
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Publication number: 20190248735Abstract: The invention provides a bio-based acrylic monomer, particularly a plant oil-based acrylic monomer, which is well-suited for emulsion polymerization and latex formation in aqueous medium. Polymers and copolymers formed from the bio-based acrylic monomer are also provided. The invention further provided methods for making the monomer from bio-based triglycerides or fatty esters.Type: ApplicationFiled: April 26, 2019Publication date: August 15, 2019Applicant: NDSU Research FoundationInventors: Andriy Voronov, Ihor Tarnavchyk
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Publication number: 20190248736Abstract: The present invention relates to a pseudo-ceramide compound and a preparation method therefor. According to the present invention, the pseudo-ceramide compound has a molecular structure and a function similar to those of a natural ceramide, can be readily synthesized, and has excellent solubility in an organic solvent and excellent stability, and thus the pseudo-ceramide compound can be used as an alternative to a natural ceramide. Therefore, the pseudo-ceramide compound of the present invention can be widely applied to a skin preparation for external use, a cosmetic composition, and the like for reinforcing and maintaining a skin barrier function.Type: ApplicationFiled: September 14, 2017Publication date: August 15, 2019Applicant: AMOREPACIFIC CORPORATIONInventors: Yung Hyup JOO, Jae Won YOO, Yong Jin KIM, Ho Sik RHO, John Hwan LEE
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Publication number: 20190248737Abstract: The present invention discloses a biaryl urea ROR?t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR?t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR?t-related disease.Type: ApplicationFiled: June 19, 2017Publication date: August 15, 2019Inventors: Yonghui WANG, Yafei HUANG, Fazhi YU, Ting TANG
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Publication number: 20190248738Abstract: Phenyldifluoromethyl-substituted prolinamide compounds that have a cathepsin S inhibitory effect, and are usable as active ingredients of pharmaceutical compositions for preventing and/or treating autoimmune diseases including systemic lupus erythematosus (SLE) and lupus nephritis, allergies, or graft rejection of an organ, bone marrow or tissue.Type: ApplicationFiled: April 25, 2019Publication date: August 15, 2019Applicant: Astellas Pharma Inc.Inventors: Yutaka Nakajima, Sunao Imada, Eriko Yamamoto, Kazuyuki Tsuchiya, Yu Harayama, Shunichiro Matsumoto
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Publication number: 20190248739Abstract: Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.Type: ApplicationFiled: February 15, 2019Publication date: August 15, 2019Inventors: Mario MAUTINO, Sanjeev KUMAR, Firoz JAIPURI, Jesse WALDO, Hima POTTURI, Hong ZHUANG
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Publication number: 20190248740Abstract: Provided is a method for preparing apremilast of formula I. Method one: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III in an aprotic solvent to produce the compound of formula I; method two: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III in an organic solvent in the presence of an organic alkali or an alkali metal hydride to produce the compound of formula I. The method for preparing apremilast requires inexpensive raw materials and reagents, is suitable for industrial production, and has great economic effects.Type: ApplicationFiled: June 30, 2017Publication date: August 15, 2019Inventors: Xiaoqiu DU, Lianchao ZHOU, Jiegen LIU
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Publication number: 20190248741Abstract: The invention relates to an organic molecule, in particular for use in optoelectronic components.Type: ApplicationFiled: July 10, 2017Publication date: August 15, 2019Inventor: Daniel Zink
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Publication number: 20190248742Abstract: A molecular building block composition can include a metal ion component; and a ligand component including a core including at least one functional group associated with the metal ion component and the core.Type: ApplicationFiled: April 29, 2019Publication date: August 15, 2019Inventors: Mohamed EDDAOUDI, Dongxu XUE, Ryan LUEBKE, Vincent GUILLERM, Abdul Malik Puthan PEEDIKAKKAL, Karim ADIL, Lukasz WESELINSKI
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Publication number: 20190248743Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.Type: ApplicationFiled: September 13, 2018Publication date: August 15, 2019Applicant: THERAVANCE BIOPHARMA R&D IP, LLCInventor: Grahame Woollam
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Publication number: 20190248744Abstract: The present disclosure relates to certain amides and heterocyclic compounds. The present disclosure also relates to uses of these compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graft versus host disease (GVHD), inflammation, cardiovascular disorders, central nervous system disorders, and neoplastic disorders.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Inventors: Tong Wang, Stephen Gately
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Publication number: 20190248745Abstract: The invention relates to pyridone amide compounds of formula I and I? or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.Type: ApplicationFiled: August 21, 2018Publication date: August 15, 2019Inventors: Sara Sabina Hadida Ruah, Corey Anderson, Vijayalaksmi Arumugam, Iuliana Luci Asgian, Brian Richard Bear, Andreas P. Termin, James Philip Johnson