Patents Issued in August 27, 2019
  • Patent number: 10392309
    Abstract: A ceramic porous body has an alumina porous body made up by binding aggregate alumina particles to each other, the aggregate alumina particles being bound to each other by a compound including gadolinium silicate, lanthanum silicate or yttrium silicate synthesized from a silicate mineral and at least one rare-earth oxide selected from Gd2O3, La2O3, and Y2O3, and an inorganic porous film formed on the alumina porous body.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: August 27, 2019
    Assignee: NORITAKE CO., LIMITED
    Inventors: Hirokazu Watanabe, N. Nair Balagopal
  • Patent number: 10392310
    Abstract: The porous plate-shaped filler aggregate includes a plurality of the porous plate-shaped fillers. The porous plate-shaped fillers have a uniform plate shape with an aspect ratio of 3 or more, a minimum length of 0.1 to 50 ?m, a porosity of 20 to 99%, and the deviation of the maximum length among a plurality of the porous plate-shaped fillers, which is obtained by the following formula, is 10% or less. Deviation of the maximum length (%)=standard deviation of the maximum length/average value of the maximum length×100 (Here, ‘maximum length’ is the longest length when the porous plate-shaped fillers are held between a pair of parallel planes.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: August 27, 2019
    Assignee: NGK Insulators, Ltd.
    Inventors: Akinobu Oribe, Hiroharu Kobayashi, Takahiro Tomita, Shinsaku Maeda, Yasutaka Awakura
  • Patent number: 10392311
    Abstract: Methods for producing Polymer Derived Ceramic (PDCs) particles and bulk ceramic components and compositions from partially cured gelatinous polymer ceramic precursors and unique bulk composite PDC ceramics and unique PDC ceramic particles in size and composition. Methods of making fully dense PDCs over approximately 2 ?m to approximately 300 mm in diameter for applications such as but not limited to proppants, hybrid ball bearings, catalysts, and the like. Methods can include emulsion processes or spray processes to produce PDCs. The ceramic particles and compositions can be shaped and chemically and materially augmented with enhancement particles in the liquid resin or gelatinous polymeric state before being pyrolyzed into ceramic components. Nano-sized ceramic particles are formed from the green body produced by methods for making bulk, dense composite ceramics. The resulting ceramic components have a very smooth surface and are fully dense, not porous as ceramic components from the sol-gel process.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: August 27, 2019
    Assignee: Dynamic Material Systems, LLC
    Inventors: Arnold Hill, William Easter
  • Patent number: 10392312
    Abstract: An article includes a ceramic-based substrate and a barrier layer on the ceramic-based substrate. The barrier layer includes a matrix of barium-magnesium alumino-silicate or SiO2, a dispersion of silicon oxycarbide particles in the matrix, and a dispersion of particles, of the other of barium-magnesium alumino-silicate or SiO2, in the matrix.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: August 27, 2019
    Assignee: United Technologies Corporation
    Inventors: Xia Tang, Paul Sheedy, Tania Bhatia Kashyap, Wayde R. Schmidt, Daniel G. Goberman
  • Patent number: 10392313
    Abstract: The present invention relates to a method for applying biochar to turf and landscape to allow the turf and landscape to be effectively maintained under reduced water and/or reduced fertilizer applications.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: August 27, 2019
    Assignee: Cool Planet Energy Systems, Inc.
    Inventors: Richard W. Wilson, Han Suk Kim, Ranko Panayotov Bontchev, Neil Christopher Wahlgren, Vern Traxler, Timothy Alan Thompson, Brian Buege, Mark L. Jarand
  • Patent number: 10392314
    Abstract: A high strength engineered reactive matrix composite that includes a core material and a reactive binder matrix combined in high volumes and with controlled spacing and distribution to produce both high strength and controlled reactivity. The engineered reactive matrix composite includes a repeating metal, ceramic, or composite particle core material and a reactive binder/matrix, and wherein the reactive/matrix binder is distributed relatively homogeneously around the core particles, and wherein the reactivity of the reactive binder/matrix is engineered by controlling the relative chemistry and interfacial surface area of the reactive components. These reactive materials are useful for oil and gas completions and well stimulation processes, enhanced oil and gas recovery operations, as well as in defensive and mining applications requiring high energy density and good mechanical properties.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 27, 2019
    Assignee: Powdermet, Inc.
    Inventors: Andrew J. Sherman, Brian P. Doud
  • Patent number: 10392315
    Abstract: An integrated process for the production of propene from a mixture of alcohols obtained by IBE (Isopropanol-Butanol-Ethanol) fermentation from at least one renewable source of carbon is disclosed. The process is characterized by dehydration of the alcohols in order to generate ethene, propene and linear butenes, respectively. The olefin mixture is then directed to an isomerization bed in order to generate 2-butene from 1-butene, followed by a metathesis bed to react ethene and 2-butenes to generate additional propene. This process exhibits a yield in carbon moles higher than 90% propene with respect to the alcohols produced in the fermentation step.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 27, 2019
    Assignee: Braskem S.A.
    Inventors: Luiza Roza, Luiz Claudio Macedo Cassiano Filho, Antonio Luiz Ribeiro de Castro Morschbacker
  • Patent number: 10392316
    Abstract: The present invention relates to minimizing benzene, toluene, and an A9/A10 recycle loop in a zero benzene aromatics complex. More specifically, the present invention relates to a minimizing benzene, toluene, and an A9/A10 recycle loop in a zero benzene aromatics complex wherein the aromatic feed has a low methyl to phenyl ratio, and where the aromatic feed has a high methyl to phenyl ratio.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: August 27, 2019
    Assignee: UOP LLC
    Inventors: Elizabeth A. Carter, Deng-Yang Jan, Timur V. Voskoboynikov
  • Patent number: 10392317
    Abstract: The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose, starch, sugar) and ethylene in the presence of a catalyst. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (DMF), which may be converted into para-xylene by cycloaddition of ethylene to DMF. Para-xylene can then be oxidized to form terephthalic acid.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: August 27, 2019
    Assignee: MICROMIDAS, INC.
    Inventors: Makoto N. Masuno, Ryan L. Smith, John Bissell, II, Patrick B. Smith, Dennis A. Hucul, Edmund J. Stark, Daniel R. Henton, Adina Dumitrascu, Katherine Brune, Dimitri A. Hirsch-Weil
  • Patent number: 10392318
    Abstract: The present invention provides a modified composite molecular sieve, and a preparation method and an application of the modified composite molecular sieve. The modified composite molecular sieve comprises SiO2 and a composite molecular sieve that comprises molecular sieve MCM-22 and crystalline molecular sieve selected from at least one of ZSM-22, ZSM-23 and ZSM-48, wherein, the molecular sieve MCM-22 covers around the crystalline molecular sieve. The present invention further provides a catalyst and an application of the catalyst. The catalyst comprises a carrier and a noble metal loaded on the carrier, wherein, the carrier comprises a modified composite molecular sieve that is the modified composite molecular sieve provided in the present invention or the modified composite molecular sieve obtained with the method provided in the present invention.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: August 27, 2019
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, FUSHUN RESEARCH INSTITUTE OF PETROLEUM AND PETROCHEMICALS, SINOPEC CORP.
    Inventors: Huiqing Xu, Quanjie Liu, Liming Jia, Wei Wang
  • Patent number: 10392319
    Abstract: Manage sulfur present as sulfur or a sulfur compound in a hydrocarbon feedstream while effecting dehydrogenation of hydrocarbon(s) (e.g. propane) contained in the hydrocarbon feedstream to its/their corresponding olefin (e.g. propylene where the hydrocarbon is propane) without subjecting the feedstream to desulfurization before it contacts a fluidizable dehydrogenation catalyst that is both a desulfurant and a dehydrogenation catalyst and comprises gallium and platinum on an alumina or alumina-silica catalyst support with optional alkali or alkaline earth metal such as potassium. Contact with such a catalyst yields a desulfurized crude olefin product that corresponds to the hydrocarbon and has a reduced amount of sulfur or sulfur compounds relative to the sulfur or sulfur compounds present in the hydrocarbon feedstream prior to contact with the catalyst.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: August 27, 2019
    Assignee: Dow Global Technologies LLC
    Inventors: Matthew T. Pretz, Lin Luo, Brien A. Stears, Mark W. Stewart
  • Patent number: 10392320
    Abstract: Described herein are methods useful for preparing alkylaromatics.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: August 27, 2019
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Alan S. Goldman, Andrew M. Steffens, William Schinski
  • Patent number: 10392321
    Abstract: Processes for transalkylation of aromatic hydrocarbons is disclosed. The process includes introducing a feed stream comprising aromatic hydrocarbon compounds to a transalkylation zone. A water source is introduced to the transalkylation zone, the water source being in an amount to provide about 80 to about 120 wppm of water based upon the mass of the feed stream. The feed stream is contacted with a transalkylation catalyst in the transalkylation zone under transalkylation conditions comprising a transalkylation temperature of about 130° C. to about 230° C. in the presence of the water to provide a transalkylation reaction effluent.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: August 27, 2019
    Assignee: UOP LLC
    Inventors: Nishesh Garg, Stephen W. Sohn, Amit Sharma, Priyesh J. Jani, Sarbotrika Sengupta
  • Patent number: 10392322
    Abstract: The present invention relates to an improved extractive distillation process for recovering aromatic hydrocarbons from non-aromatic hydrocarbons in naphtha streams containing heavy hydrocarbon contaminants wherein each contaminant is characterized as having a boiling point in the range of between that of the separated non-aromatic hydrocarbons and the extractive distillation solvent utilized to recover and purify the aromatic hydrocarbons.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: August 27, 2019
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventor: Timothy P. Bender
  • Patent number: 10392323
    Abstract: The present application relates to an apparatus and method for purifying cumene. The apparatus and method for purifying cumene according to the present application can reduce the amount of energy consumption which occurs during purification processes and can provide an apparatus and method capable of efficiently purifying cumene.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: August 27, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Sung Kyun Kim, Sung Kyu Lee, Joon Ho Shin
  • Patent number: 10392324
    Abstract: A process to separate paraxylene from a mixture of paraxylene, metaxylene, orthoxylene, and ethylbenzene in a commercial simulated moving bed apparatus in a reduced number of beds is provided, allowing an additional separation to be conducted in the remaining beds. This additional separation may separate another xylene isomer, ethylbenzene, or a non-aromatic C8+ hydrocarbon from the raffinate stream produced by the first separation. A PowerFeed process is used to recover paraxylene in a first adsorption zone containing 8-16 beds of a conventional 24-bed simulated moving bed adsorption apparatus, and then a second separation may be conducted in a second adsorption zone containing the remaining beds.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: August 27, 2019
    Assignees: EXXONMOBIL CHEMICAL PATENTS INC., GEORGIA TECH RESEARCH CORPORATION
    Inventors: Michael W. Weber, Yoshiaki Kawajiri, Michael Salciccioli, John R. Porter, Gaurav Agrawal, Dana L. Pilliod, Siwei Guo, Jason Bentley
  • Patent number: 10392325
    Abstract: The present invention provides: a method for producing a fluorinated alkane represented by the formula (2): R2—F, wherein an alcohol having 3 to 5 carbon atoms is fluorinated by a fluorinating agent represented by the formula (1): R1SO2F in the absence of a solvent, and in the presence of an amidine base. In the formula, R1 represents a methyl group, an ethyl group or an aromatic group, R2 represents an alkyl group having 3 to 5 carbon atoms, and n is 0 or 2.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: August 27, 2019
    Assignees: Kanto Denka Kogyo Co., Ltd., ZEON CORPORATION
    Inventors: Kazuki Kurihara, Tatsuya Sugimoto
  • Patent number: 10392326
    Abstract: The present invention provides an economically advantageous method for efficiently producing a fluorine-containing compound while ensuring high conversion of the starting compound, reducing production of 245cb, and reducing equipment costs and energy costs.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 27, 2019
    Assignee: DAIKIN INDUSTRIES, LTD.
    Inventors: Daisuke Karube, Takehiro Chaki
  • Patent number: 10392327
    Abstract: A method for producing methyl fluoride, comprising the steps of: (1) pyrolyzing a starting compound in a gas phase to thereby obtain a mixed gas containing methyl fluoride and acid fluoride; and (2) rectifying the mixed gas obtained in step (1) to thereby obtain methyl fluoride.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 27, 2019
    Assignee: DAIKIN INDUSTRIES, LTD.
    Inventors: Shingo Nakamura, Yuusuke Etou, Keisuke Tano, Yoshinori Tanaka
  • Patent number: 10392328
    Abstract: A low-carbon environmentally-friendly foamer composition is disclosed. The composition includes the following ingredients in mass percentage: 60-98.99% of 1-chloro-3,3,3-trifluoropropene, 1-39.9% of 1,1,1,2,3-pentafluoropropane and 0.01-1% of 1,2,2,3-tetrafluoropropane. The GWP value of the low-carbon environmentally-friendly foamer composition is smaller than the GWP value of a single-medium HFC-245fa. This low-carbon environmentally-friendly foamer composition has the features of environmental protection, excellent foaming performance and little modification of foaming devices, and can reduce the heat conductivity coefficient and overall energy consumption level. Therefore, the low-carbon environmentally-friendly foamer composition is the best choice for high-performance hard insulating foam, and is an ideal choice of future foamer.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: August 27, 2019
    Assignee: Zhejiang Quhua Fluor-Chemistry Co Ltd
    Inventors: Jiangyong Hong, Bo Yang, Yang Zhao, Yan Zhang, Huadong Zhou, Hao Ouyang, Haitao Gong, Min Fang
  • Patent number: 10392329
    Abstract: A method and a device for condensing a water-soluble organic matter, which can collect a highly concentrated water-soluble organic matter, save energy, and reduce cost of the device by reducing a membrane area. According to the present invention, the permeability ratio of a vapor-permeation separation membrane disposed at least immediately before a final outlet on a non-permeation side in the separation membrane device is lower than those of the other vapor-permeation separation membranes while a hybrid process combining distillation by the distillation column with membrane separation by the separation membrane devices including a plurality of vapor-permeation separation membranes is used and energy saving performance is maintained. Therefore, a highly concentrated and condensed component of a water-soluble organic matter is obtained.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: August 27, 2019
    Assignees: WASEDA UNIVERSITY, MITSUBISHI CHEMICAL CORPORATION, HITACHI ZOSEN CORPORATION, CHIYODA CORPORATION
    Inventors: Masahiko Matsukata, Kenichi Kawazuishi, Kenichi Mimura
  • Patent number: 10392330
    Abstract: A process for the production of diisopropyl ether from high purity propylene without the need of a propane-propylene fractionation column has been developed. The process involves (1) reacting a high purity propylene feedstock and water to produce isopropyl alcohol in a reactor and reacting the isopropyl alcohol with propylene to produce diisopropyl ether in the presence of an acidic ion exchange resin catalyst and a propane diluent to generate a reactor effluent stream containing at least water, isopropyl alcohol, diisopropyl ether, propylene, and acid, (2) passing the reactor effluent to an acid removal zone to produce an acid-depleted stream, (3) dividing the acid-depleted stream into two portions, (4) recycling a portion to the reactor (5) allowing propane to build-up to an amount sufficient to operate as a diluent and (6) recovering product diisopropyl alcohol.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: August 27, 2019
    Assignee: UOP LLC
    Inventors: Charles P. Luebke, Steven L. Krupa
  • Patent number: 10392331
    Abstract: A process for the production of diisopropyl ether from high purity propylene without the need of a propane-propylene fractionation column has been developed. The process involves (1) reacting a high purity propylene feedstock and water to produce isopropyl alcohol in a reactor and reacting the isopropyl alcohol with propylene to produce diisopropyl ether in the presence of an acidic ion exchange resin catalyst and a C4 diluent to generate a reactor effluent stream containing at least water, isopropyl alcohol, diisopropyl ether, propylene, and acid, (2) passing the reactor effluent to an acid removal zone to produce an acid-depleted stream, (3) dividing the acid-depleted stream into two portions, (4) recycling a portion to the reactor (5) purging a portion to prevent propane build-up and (6) recovering product diisopropyl alcohol.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 27, 2019
    Assignee: UOP LLC
    Inventor: Steven L. Krupa
  • Patent number: 10392332
    Abstract: The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to compositions comprising these compounds.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: August 27, 2019
    Assignee: MERCK PATENT GmbH
    Inventors: Reiner Friedrich, Gerhard Jonschker
  • Patent number: 10392333
    Abstract: A method for producing formaldehyde from methanol. The method includes the steps of packing a catalyst comprising platinum, bismuth and a support material into a reactor, introducing a reactant mixture containing methanol into the reactor such that the reactant mixture containing methanol is in close contact with the catalyst, and heating the reactant mixture containing methanol to a temperature for a period of time.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 27, 2019
    Assignee: Purdue Research Foundation
    Inventors: Arvind Varma, Yang Xiao
  • Patent number: 10392334
    Abstract: A method and a system for inexpensively producing a corresponding target ketone and/or alcohol by decomposing hydroperoxide rapidly and with high selectivity using an aqueous alkaline solution and by recovering and recycling alkali. The method includes neutralizing at least a part of a carboxylic acid in the oxidation reaction solution by contacting the oxidation reaction solution with a first alkaline solution including a carbonate of an alkali metal, and separating the reaction mixture into a first oil phase and a first water phase; decomposing the hydroperoxide and the ester compound in the first oil phase by contacting the first oil phase with a second alkaline solution having a higher pH value than the first alkaline solution, and separating the reaction mixture into a second oil phase and a second water phase; and recovering the carbonate of an alkali metal from the first water phase and recycling the carbonate of an alkali metal to the first alkaline solution.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: August 27, 2019
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Yoshinori Sugimura, Kazunori Kurosawa, Kazuo Yamato, Junichi Kugimoto, Joji Kawai, Wanna Sirisuksukon, Nantariya Ngamsup
  • Patent number: 10392335
    Abstract: There is provided a method for producing hydroxypivalaldehyde (HPA), including steps (i) to (iii) below in this order, Step (i): a reaction step of reacting IBAL with FA to produce a reaction solution containing HPA, step (ii): an extraction step of extracting the reaction solution with an aldehyde solvent represented by formula (1) under basicity to obtain an extract containing HPA, and step (iii): a distillation and collection step of distilling the extract and then collecting HPA from the residue, wherein R represents a saturated alkyl group having 3 or more and 7 or less carbon atoms, further wherein the distillation step of the step (iii) is a step of distilling an extract in the presence of water, and an amount of the water which is subjected to the distillation is 100 parts by mass or more and 2,000 parts by mass or less with respect to a total amount, 100 parts by mass, of isobutyraldehyde (IBAL) derived from a raw material and an aldehyde solvent represented by formula (1) in an extract
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: August 27, 2019
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yumi Sato, Masahiro Yamane
  • Patent number: 10392336
    Abstract: This disclosure provides for routes of synthesis of acrylic acid and other ?,?-unsaturated carboxylic acids and their salts, including catalytic methods. For example, there is provided a process for producing an ?,?-unsaturated carboxylic acid or a salt thereof, the process comprising: (1) contacting in any order, a group 8-11 transition metal precursor, an olefin, carbon dioxide, a diluent, and a polyaromatic resin with associated metal cations to provide a reaction mixture; and (2) applying conditions to the reaction mixture suitable to produce the ?,?-unsaturated carboxylic acid or a salt thereof. Methods of regenerating the polyaromatic resin with associated metal cations are described.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: August 27, 2019
    Assignee: Chevron Phillips Chemical Company LP
    Inventors: Pasquale Iacono, Mark L. Hlavinka
  • Patent number: 10392337
    Abstract: A process for purifying methyl methacrylate. The method comprises: (a) feeding a product mixture comprising methyl methacrylate, methanol, water and oligomers of methyl methacrylate to a divided section of a distillation column comprising a dividing wall; (b) removing an overhead stream and a bottoms stream from the distillation column, and removing a middle side draw stream from the distillation column; wherein the crude product enters the dividing wall distillation column in a divided section on an opposing side of the dividing wall from the middle side draw stream; and (c) removing an upper side draw stream from a point above the dividing wall and below the top of the distillation column, separating a portion of water from the upper side draw stream to produce a dewatered upper side draw stream and returning the dewatered upper side draw stream to the distillation column.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: August 27, 2019
    Assignee: Dow Global Technologies LLC
    Inventors: Dennis W. Jewell, John G. Pendergast, Jr., William G. Worley
  • Patent number: 10392338
    Abstract: The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorder or symptom associated therewith.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: August 27, 2019
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY, OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Dmitry Tsvelikhovsky, Avi Priel
  • Patent number: 10392339
    Abstract: Provided is a polar compound having high chemical stability, high capability of aligning liquid crystal molecules, high solubility in a liquid crystal composition, and a large voltage holding ratio when used in a liquid crystal display device. The compound is represented by formula (1): in which, for example, R1 is alkyl having 1 to 15 carbons; MES is a mesogen group having at least one ring; Sp1 is a single bond or alkylene having 1 to 10 carbons; M1 and M2 are hydrogen; and R2 is a group represented by formulas (1a) to (1c): in which, Sp2 and Sp3 are a single bond or alkylene having 1 to 10 carbons; S1 is >CH—; S2 is >C<; and X1 is —OH.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: August 27, 2019
    Assignees: JNC CORPORATION, JNC PETROCHEMICAL CORPORATION
    Inventors: Hiroyuki Tanaka, Masakazu Yano, Fumitaka Kondou, Kazuhiro Ogita
  • Patent number: 10392340
    Abstract: The present invention is directed to a process for fine purification of isophoronediamine from the production of isophoronediamine wherein the crude isophoronediamine I is subjected to a fine purification by means of two vacuum distillation columns, wherein I. in the first vacuum distillation column K I low-boiling by-products still present are removed, and a crude IPDA II is transferred from the bottom of K I into the vacuum distillation column K II, II. and in the second vacuum distillation column K II the isophoronediamine is obtained in pure form overhead and separated from the organic residues, wherein the first condenser is a partial condenser and the pure IPDA is removed therein, and wherein the second condenser is a total condenser and the residual portion of the vapor stream from K II is completely condensed therein and recycled as return stream into the first vacuum distillation column K I.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: August 27, 2019
    Assignee: Evonik Degussa GmbH
    Inventors: Anne Rittsteiger, Jan Caßens, Axel Hengstermann, Cord Knoop, Anja Müller, Alexander Martin Rüfer
  • Patent number: 10392341
    Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: August 27, 2019
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise
  • Patent number: 10392342
    Abstract: Provided is a use of an aggregation-induced emission compound in dispersion detecting of nanoparticles. The dispersion detecting of nanoparticles includes modifying the aggregation-induced emission compound on the surfaces of the nanoparticles to obtain a modified nanoparticles solution. The dispersion detecting of nanoparticles includes exciting the modified nanoparticles solution and determining the dispersion of the nanoparticles by the luminescence state of the solution.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: August 27, 2019
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Zhenqi Zhang
  • Patent number: 10392343
    Abstract: The present invention is a polymerizable compound represented by a general formula (I), a polymerazable composition, a polymer, and an optically anisotropic product.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: August 27, 2019
    Assignee: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama
  • Patent number: 10392344
    Abstract: The present invention relates to a method for labelling fluorine-18, which is a radioisotope, and more specifically, to a method for labelling a [18F]fluoride in a method for preparing an organic [18F]fluoro compound by reacting an alkyl halide or an alkyl sulfonate with a [18F]fluoride, wherein a [18F]fluoride supported on a quaternary alkyl ammonium polymer support is eluted using a solution containing a metal salt or a quaternary ammonium salt with an adjusted pH, and a base is not additionally used. The present invention enables a labeling reaction without an additional base after precisely reflecting the concentration of a base absolutely necessary for the nucleophilic substitution of a [18F]fluoride or eluting a [18F]fluoride using a [18F]fluoride eluent with an adjusted pH, thereby stably obtaining a [18F]fluoride-labelled compound in a high yield, and is thus useful for production of fluorine-18-labelled radioactive medical supplies.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 27, 2019
    Assignee: THE ASAN FOUNDATION
    Inventors: Sang Ju Lee, Seung Jun Oh, Dae Hyuk Moon, Jin Sook Ryu, Jae Seung Kim, Jong Jin Lee
  • Patent number: 10392345
    Abstract: Disclosed herein are a crystal comprising a compound, which has ?-opioid receptor antagonistic action, few side effects, and high safety, and having high purity and excellent physical properties (stability, solubility, etc.), and a method for producing the crystal. The crystal is a crystal of a salt comprising: a compound represented by a formula (I) [wherein R2 is a hydrogen atom or a halogen atom, and R1 is a group selected from the group consisting of and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, and oxalic acid, or a hydrate thereof.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: August 27, 2019
    Assignees: SANWA KAGAKU KENKYUSHO CO., LTD., UBE INDUSTRIES, LTD.
    Inventors: Ryo Iwamura, Yasunori Tsuzaki, Hiroyuki Setoguchi, Hiroto Akaza, Yasuhito Yamamoto, Akira Takama, Yuka Kuno
  • Patent number: 10392346
    Abstract: There are provided compounds of formula IIb, wherein: LG1 represents imidazolyl, chloro, or aryloxy; and Z1 represents a structural fragment of formula V: wherein R2 to R4, R5a, L and X1 to X3 have meanings given in the description, or a salt or protected derivative thereof, wherein said protected derivative is a compound in which the carboxyl moiety of R4 is protected as a C1-8 alkyl ester. The compounds have antiinflammatory activity, for example through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: August 27, 2019
    Assignee: Topivert Pharma Limited
    Inventors: Thomas Matthew Baker, Matthew Colin Thor Fyfe, Geraint Jones, Stephen Malcolm Thom
  • Patent number: 10392347
    Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: August 27, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Soong-Hoon Kim, Hannguang J. Chao, Heather Finlay, Ji Jiang, James A. Johnson, R. Michael Lawrence, Michael C. Myers, Monique Phillips, George O. Tora, Wei Meng
  • Patent number: 10392348
    Abstract: The present invention relates to novel sulfonamide derivatives of formula (I), to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants, improving plant tolerance to abiotic stress (including environmental and chemical stresses), inhibiting seed germination and/or safening a plant against phytotoxic effects of chemicals.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 27, 2019
    Assignee: Syngenta Participations AG
    Inventors: Mathilde Denise Lachia, Sebastian Volker Wendeborn, Pierre Joseph Marcel Jung, Davide Sabbadin, Olivier Loiseleur, Andreas Beck
  • Patent number: 10392349
    Abstract: Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 27, 2019
    Assignee: NOVIRA THERAPEUTICS, INC.
    Inventors: George D. Hartman, Scott Kuduk
  • Patent number: 10392350
    Abstract: The invention provides pyrazolyl guanidine compounds that inhibit F1F0-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic agents to treat medical disorders, such as an immune disorder, inflammatory condition, or cancer.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: August 27, 2019
    Assignee: Lycera Corporation
    Inventors: Thomas D. Aicher, Donald J. Skalitzky, Clarke B. Taylor
  • Patent number: 10392351
    Abstract: Disclosed in the present invention is a method for preparing nilotinib intermediate 3-(4-methyl-1H-imidazol-1-yl)-5trifluoromethyl phenylamine (I). The method comprises the following steps: taking trifluorotoluene as an initial material, and preparing the nilotinib intermediate (I) by nitration, bromization, condensation and reduction successively Compared with the prior art, the preparation method has the following advantages: a relatively high yield, the raw materials are easily obtained, a concise process and few side reactions, and is adapted to industrial production, so the development of an economic technology of the bulk drug is promoted.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: August 27, 2019
    Assignees: SUZHOU LIXIN PHARMACEUTICAL CO., LTD.
    Inventors: Xuenong Xu, Deli Zeng, Liang Shu, Qing Zhang, Zhijian Bao, Jia Xue, Jian Su, Zhe Wang, Wenjie Zhou, Lingling Xie
  • Patent number: 10392352
    Abstract: The present invention discloses an etomidate derivative of Formula 1, or a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, a pharmaceutical composition and a kit comprising the same, as well as intermediates and methods for preparing the same, and use thereof. The etomidate derivative of the present invention not only has good anesthetic activity, rapid onset, and short duration of action, but also shows little inhibition to the secretion of corticosteroids in animals, and therefore has both favorable anesthetic effect and safety profiles.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: August 27, 2019
    Assignee: JIANGSU NHWALUOKANG PHARMCEUTICAL RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Qingeng Li, Tao Wang, Lingguo Zeng, Guisheng Zhang, Xiangqing Xu, Liang Ren
  • Patent number: 10392353
    Abstract: Disclosed herein is a novel process for preparing substituted quinazoline compounds of formula (I) using a hydrogen bonding catalyst.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 27, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Cheol K. Chung, Guy R. Humphrey, Zhijian Liu, Mark McLaughlin, Yingju Xu, Younong Yu
  • Patent number: 10392354
    Abstract: Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: August 27, 2019
    Assignee: The University of Toledo
    Inventors: Viranga Tillekeratne, William Taylor, Sara Fedorka
  • Patent number: 10392355
    Abstract: Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: August 27, 2019
    Assignee: GEISTLICH PHARMA AG
    Inventor: Rolf W. Pfirrmann
  • Patent number: 10392356
    Abstract: Ester derivatives of sobetirome with enhanced CNS distribution are disclosed.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: August 27, 2019
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Thomas S. Scanlan, Andrew Placzek, Tapasree Banerji, Sky Ferrara, James Matthew Meinig
  • Patent number: 10392357
    Abstract: Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders associated with hyperglycemia.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 27, 2019
    Assignee: Acaemia Sinica
    Inventors: Rong-Jie Chein, Klim King, Nai-Pin Lin, Yu-Hong Cheng
  • Patent number: 10392358
    Abstract: Provided herein are methods of producing halomethylfuroic and acyloxymethylfuroic acid and ester compounds from furfural starting compounds. For example, 5-chloromethyl-2-furoic acid may be produced from 5-chloromethylfurfural, in the presence of various oxidants. Salts of the furoic acids may also be produced.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: August 27, 2019
    Assignee: Micromidas, Inc.
    Inventors: Daniel R. Henton, Makoto Nathanael Masuno, Ryan L. Smith, Alex B. Wood, Dimitri A. Hirsch-Weil, Christian T. Goralski, Robert Joseph Araiza