Abstract: A method of adjusting flaw detection sensitivity on an array ultrasonic probe comprises disposing a plate material P1 oppositely to the ultrasonic probe such that an upper surface of the plate material is disposed to be approximately parallel to an array direction of the transducers 11, or disposing a tubular material P2 oppositely to the ultrasonic probe such that an axial direction of the tubular material is disposed to be approximately parallel to the array direction of the transducers. Ultrasonic waves are transmitted from each transducer toward the upper surface of the plate material or an outer surface of the tubular material, and echoes are received from the bottom surface of the plate material or an inner surface of the tubular material on each transducer. Flaw detection sensitivity of each transducer is adjusted to substantially equalize intensity of an echo received on each transducer.

Abstract: An apparatus for use in Ultrasonic testing, and a method of inspection or testing using the apparatus. The ultrasonic testing tool includes an elongate connector arranged between a transducer and a tip or contact head for contact with the component to be tested. The elongate connector carries soundwaves produced by the transducer between the transducer and the contact head.

Abstract: A method for determining concentration and pressure of respective gas consisting of multi-gas using emitting and receiving of ultrasound includes: measuring a reference ultrasound flight time; measuring ultrasound flight times at plural concentrations, temperatures and pressures; obtaining an ultrasound flight time table comprising ultrasound flight time change values which are differences between the reference ultrasound flight time, which varies according to parameters of concentration, temperature and pressure, and the measured ultrasound flight time; obtaining an ultrasound amplitude table comprising ultrasound amplitude values of a waveform of a predetermined sequence of the received ultrasound waveform at plural concentrations, temperatures and pressures in a state that concentration, temperature and pressure of the target respective gas are parameters; and calculating the concentration and the pressure of the target gas based on performing temperature compensations for the ultrasound flight time change

Abstract: A “periodic signal parameter” (PSP) indicates periodic patterns in an autocorrelated vibration waveform and potential faults in a monitored machine. The PSP is calculated based on statistical measures derived from an autocorrelation waveform and characteristics of an associated vibration waveform. The PSP provides an indication of periodicity and a generalization of potential fault, whereas characteristics of the associated waveform indicate severity. A “periodic information plot” (PIP) is derived from a vibration signal processed using two analysis techniques to produce two X-Y graphs of the signal data that share a common X-axis. The PIP is created by correlating the Y-values on the two graphs based on the corresponding X-value. The amplitudes of Y-values in the PIP is derived from the two source graphs by multiplication, taking a ratio, averaging, or keeping the maximum value.

Abstract: An autosampler is provided with a needle that has a capacity to retain a sample therein and has both ends each formed in a pointed shape, a first adapter that has an opening and causes the needle and a syringe pump to be in communication with each other through the insertion of the upper end part of the needle into the opening, and a second adapter that connects the needle and a mobile-phase liquid-delivery flow path using a structure similar to that of the first adapter. The autosampler is configured such that the first adapter and the second adapter are attached to and removed from the upper end part of the needle so as to create flow paths including the needle as necessary and carry out a sampling operation and injecting operation.

Abstract: A back pressure valve configured to switch between a pressurized state and a released state open to an atmosphere is used as a back pressure valve in a supercritical fluid chromatograph. Switching from a state of supercritical fluid chromatography analysis to liquid chromatography is performed by stopping a pump that supplies a supercritical fluid, continuously operating a pump that supplies a solvent used as a modifier, and bringing the back pressure valve into the released state.

Abstract: Provided is a system comprising a device that performs one or more reactions to liquid or supercritical fluid chromatograph effluents and produces molecules that are subsequently detected by a suitable detector. This allows for one to practice a method for the detection and quantification of organic molecules from a liquid chromatograph for the purpose of increasing detection limits and allowing for the universal detection of organic molecules. The linear dynamic range and molecular response are greater than those previously available.

Abstract: A mass spectrometry data processing apparatus includes a computation unit and a seeking unit. The computation unit calculates the mass difference ?m/z between the peaks of two molecules selected from mass spectrum data or obtains the mass difference ?m/z. The seeking unit estimates a combination of atoms between the peaks of the two molecules in a range of the mass difference ?m/z. The seeking unit seeks the combination of atoms having a mass difference, which matches the mass difference ?m/z, between a set of atoms desorbed from a first molecule of the two molecules and a set of atoms added to the first molecule.

Abstract: For improving sensitivity, dynamic range, and specificity of GC-MS analysis there are disclosed embodiments of novel apparatuses based on improved characteristics of semi-open source with electron impact ionization, providing much higher brightness compared to known open EI sources. In an implementation, the source becomes compatible with multi-reflecting TOF analyzers for higher resolution analysis for improving detection limit. With improved schemes of spatial and temporal refocusing there are proposed various tandem TOF-TOF spectrometers with PSD, CID, and SID fragmentation and using either singly reflecting TOF or MR-TOF analyzers.

Abstract: A detection method for low molecular weight heparin complete degradation products using hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry. Identifying the original reducing end and non-reducing end of enoxaparin sodium by means of reducing the reducing end of enoxaparin sodium, and performing hydrolysis using hydrogen peroxide. Performing quantitative analysis on all component units utilizing hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry, in particular quantifying low-content special structures and characterizing low molecular weight heparin.

Abstract: A chromatographic data processing device, data processing method, and chromatographic analysis system. When chromatographic analysis is performed, the data processing device obtains 3D data for time, wavelength, and strength from the PDA, and finds the assay value for the target component in the liquid sample by processing said data. If the peak top strength of the target component falls outside of the dynamic range, a dilution ratio for the liquid sample is determined by calculating the peak top strength of the target component using the ratio of the strength at the peak top wavelength on the spectrum for each point in time belonging to the peak to the strength of a separate wavelength.

Abstract: The EM algorithm for a Gaussian mixture model is applied to the separation of peaks that overlap one another on a chromatogram. However, the number of overlapping components is unknown. Thus, a suitable number of models is set, and the fitting of model parameters is performed while an actually measured signal is appropriately divided for each model by the EM algorithm. Then, when a solution converges, a determination is made as to whether a peak-like waveform is present in a residue signal that is not divided. When the peak-like waveform is present, a peak model is added. The EM algorithm is executed again. In the M step, optimization is performed using, not only a simple Gaussian function, but also a modified Gaussian function assuming a tailing. In the M step, the estimation of a spectrum assuming a chromatogram and the estimation of a chromatogram assuming a spectrum are repeatedly performed.

Abstract: A preparative liquid chromatographic apparatus comprising a column for separating components in a sample; a dispensing unit for dispensing an eluate from the column; a detector for the eluate; an analysis unit for the eluate; a display unit for displaying an analysis result a data storage unit; and an arithmetic control unit for controlling the display unit and the data storage unit. The analysis unit has at least one qualitative analysis unit for continuously and qualitatively analyzing the eluate. The display unit simultaneously displays a chromatogram acquired by the detector and the acquisition position of the dispensing unit and displays a correspondence relationship between each fraction and the chromatogram, and wherein by using the correspondence relationship between each fraction and the chromatogram shown in the display unit, the qualitative analysis data selected from the data storage unit is displayed on the display unit using the arithmetic control unit.

Abstract: A controlling apparatus 110 to control an operation of an analyzing apparatus 1 and make the analyzing apparatus 1 execute a predetermined analysis, the controlling apparatus 110 including: a communicating module 60 that maintains reception of electricity when the analyzing apparatus 1 is in a power-on state, and is capable of receiving a control signal from an external apparatus 2 at all times; and a unit power controlling section 23 for acquiring the control signal through the communicating module 60, stopping electricity supply to a unit 31, 321, 322, 323 and/or 324 of the analyzing apparatus 1 at a first timing based on the control signal, and restarting the electricity supply to the unit 31, 321, 322, 323 and/or 324 at a second timing based on the control signal, so as to effectively suppress the electricity consumption when the analysis is not executed and facilitate the restart of the analysis.

Abstract: An electrodialytic device for ion chromatography, including aspects functioning as an eluent suppressor device and aspects functioning as an eluent generator device. In general, the device includes a monolithic block of ionomeric polymer material having (1) a first channel with an inlet port, an outlet port, and an active length of exposed polymer material disposed therebetween, (2) a second channel having an inlet port, an outlet port, and an active length of exposed polymer material disposed therebetween, (3) a first and second at-least-partially exposed electrodes positioned in electrical communication with the second channel, with the second electrode disposed, at least in part, across the second channel from the first electrode. A current flowing between the electrodes will drive an electrodialytic migration of ions between the active lengths, from an eluent stream in the case of a suppression device or into an eluent stream in the case of a generator device.

Abstract: Techniques are disclosed for generating a mixture of olfactory compounds to diffuse based on a flavor signature delta measured between samples prepared according to a recipe. An application obtains a flavor signature for a canonical sample prepared according to the recipe and a flavor signature for a sample subsequently prepared according to the recipe. The application generates a flavor signature delta from the flavor signatures of the samples. The flavor signature delta indicates a difference in the measure of each of the olfactory compounds in the samples. The application identifies a mixture of olfactory compounds in the flavor signature delta based on the difference. The application then directs an aroma diffusing device to diffuse the identified mixture of olfactory compounds.

Abstract: The present invention relates to a gas detector cell and cell unit for optical detection of a predetermined gas, the cell being provided with optical means for investigating a gas sample present in the cell. The cell is constituted by a volume enclosed in a container, at least part of the container wall being constituted by a membrane, the membrane being provided with openings allowing diffusion of gas therethrough, and the membrane openings being provided with a catalyst for converting the gas diffusing therethrough to said predetermined gas.

Abstract: A gas sensor comprises a metal oxide sensing patch, a heater for heating the sensing patch, electrodes for measuring the conductivity of the sensing patch and an evaluation unit for generating a resulting parameter indicative of at least one analyte. Further, a temperature sensor is provided for measuring the temperature at the location of the sensing patch. The evaluation unit is adapted to derive a first parameter indicative of the conductivity of the sensing patch and a second parameter indicative of the heating power required to maintain a desired temperature of the sensing patch or indicative of the deviation of the temperature at the sensing patch from the desired temperature. The evaluation unit further combines the first and second parameters for evaluating the resulting parameter, thereby using the sensing patch not only as a chemiresistor but also as a pellistor-type measurement device.

Abstract: Method for the detection and quantification of the H2S which measures concentration of the H2S in the drilling mud including the steps of measurement of the initial concentrations of H2S in free form and of the hydrogen sulphide HS? and sulphide S2 ? ion species, dissolved in the sample of mud; acidification of the sample of mud, to generate gaseous H2S, making the hydrogen sulphide (HS?) and sulphide (S2?) ions dissolved in the mud and the H2S precipitated in solid form in the scavengers react; measuring concentration of the gaseous H2S formed following the first acidification; and relative system including at least: a mud sample collector; a unit measuring concentration of the hydrogen sulphide HS? and sulphide S2? ion species in the sample; a unit for measuring concentration of the free H2S; a unit to acidify the sample of mud; electronic controller and storage and processing of the measurements made.

Abstract: An optoelectronic device for detecting volatile organic compounds is described, including a die with a semiconductor body, the die forming a MOSFET transistor and at least one photodiode. The optoelectronic device is optically couplable to an optical source that emits radiation with a spectrum at least partially overlapping the absorption spectrum range of the semiconductor body. The MOSFET transistor is planar and includes a gate region and a catalytic region that is arranged on the gate region such that, in the presence of a gas mixture including volatile organic compounds, the MOSFET transistor can be biased to generate an electrical signal indicating the overall concentration of the gas mixture. The photodiode generates a photocurrent that is a function of the concentration of one or more polycyclic aromatic hydrocarbons present in the gas mixture.

Abstract: A computing system performs a method of determining cumulative exposure to a gas. The computing system receives data that correspond to local concentrations of a gas from a plurality of stationary gas sensors in a home. Respective stationary gas sensors are located at respective fixed locations in respective rooms in the home. The computing system also receives data that correspond to occupancy of the home, including occupancy by a first occupant. The computing system determines a cumulative exposure of the first occupant to the gas in the home, based at least in part on the received data that correspond to local concentrations of the gas and the received data that correspond to occupancy of the home. The computing system performs and/or sends instructions to perform one or more predefined operations in accordance with the determined cumulative exposure of the first occupant.

Abstract: Methods for detecting biomarkers of inflammation, infection, and/or bacterial activity in dairy production, which indicate issues with the milk itself or issues related to the health of the cow. The methods generally comprise contacting a milk sample with a nanoplatform assembly to create an assay solution, and detecting spectral changes in the assay solution that are triggered by enzymatic activity (when present) in the sample. The nanoplatform assembly comprises a first particle, a second particle, and a linkage therebetween, wherein the linkage comprises a protease consensus sequence (the sequence of amino acids cleaved by the protease), or an ester linkage (cleaved by a protease or lipase). A plurality of second particles can also be linked to the first particle. Test strips are also described, which undergo a visual color change in the presence of the target enzyme in the milk sample.

Abstract: An evaluation method of abrasive grains used in an ingot-cutting slurry includes: an evaluation solution preparation step in which abrasive grains including polishing grains and impurities are dissolved in a solvent to prepare an evaluation solution; a sedimentation step in which a container containing the evaluation solution is left still to settle the polishing grains; a measurement step in which a turbidity of supernatant of the evaluation solution is measured using the measurement device; and an estimation step in which an amount of the impurities is estimated based on the measurement result of the turbidity of the supernatant.

Abstract: A rotary timber charger including a charging assembly and a stiffness measuring mechanism. The charging assembly includes a continuously rotating main rotatable shaft with at least two transfer wheels mounted thereto and each having a timber piece grasping assembly grasping, retaining and releasing a piece of timber continuously moved between a grasping position and a release position. The stiffness measuring mechanism includes a load application wheel positioned between consecutive transfer wheels and momentarily applying a load on the piece of timber during rotation of the piece of timber between the grasping position and the release position and a deformation measuring system measuring a deformation of the transferred piece of timber following the application of the load thereon.

Abstract: A method of manufacturing a membrane device comprises: a first step of forming a pillar structure on a part of a Si substrate by etching; a second step of forming a first insulation layer on the Si substrate so as to expose a Si surface of an upper part of the pillar structure; a third step of forming a second insulation layer on the pillar structure and the first insulation layer; and a fourth step of etching the Si substrate from an opposite side of the second insulation layer and etching the pillar structure with the first insulation layer being a mask, to thereby form a membrane, which is a region free of the pillar structure in the second insulation layer.

Abstract: A system for measuring a property of a sample in a liquid which includes a test strip and a meter is provided. Some embodiments relate to a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, the control circuit configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; and a diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit.

Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.

Abstract: Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.

Abstract: The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.

Abstract: A method for providing semen optimized for use in artificial insemination is described. Methods involve monitoring sperm cell metabolism by assays that produce results in real time, while sperm are still being processed into doses for use in insemination. Processing is modified in response to assay results, to optimize sperm performance.

Abstract: The present invention relates to a family of fluorescent compounds based on the BODIPY scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprises Pseudomonas aeruginosa and the compound specifically binds to a Fap protein of Pseudomonas aeruginosa, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-GMP).

Abstract: The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.

Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.

Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.

Abstract: The present invention encompasses a method for detecting a target comprising a repeating epitope.

Abstract: The present application discloses proteins or peptides and methods of using such proteins or peptides to evaluate the immune status of a patient. In one embodiment, proteins or peptides may be used to detect endogenous calnexin specific CD4 T cells. In one preferred embodiment, the proteins or peptides may comprise peptide-MHCII tetramers (pMHC tetramers).

Abstract: The present invention provides a method for determining whether a Rheumatoid Arthritis (RA) patient is susceptible to treatment with a B cell targeted therapy, which method comprises the step of analyzing B cells and/or germinal center-like structures (GC-LS) in a synovial tissue sample from the patient; wherein a patient whose synovial tissue sample is B cell rich and/or GC-LS negative is determined to be susceptible to treatment with the B cell targeted therapy, whereas a patient whose synovial tissue sample is B-cell poor and/or GC-LS positive is determined to be resistant to treatment with the B cell targeted therapy.

Abstract: The present invention provides use of KLRG1 as a marker specific to memory invariant NKT cells. Using an antibody that specifically recognizes KLRG1, memory invariant NKT cells can be easily detected or isolated.

Abstract: A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.

Abstract: In certain aspects, the present invention provides methods for determining whether a Her-2 positive cancer is likely to respond to treatment with a Her2-acting agent and/or whether a patient with a Her-2 positive cancer is likely to have a slow disease progression. In other aspects, the present invention is drawn to methods for determining whether a subject with a Her-2 positive cancer is unlikely to respond to treatment with at least one chemotherapeutic agent in addition to a Her2-acting agent and/or whether a patient with a Her-2 positive cancer is likely to have a fast disease progression.

Abstract: USP14 is a biomarker for recurrent disease and inhibition of USP14 is of therapeutic benefit for women with endometrial or ovarian cancer.

Abstract: The present disclosure relates generally to determining the risk of developing breast cancer. In particular, the present disclosure provides materials and methods for determining whether a subject diagnosed with a non-cancerous breast tumor will develop cancer based on expression of multiple oncogenic biomarkers in the non-cancerous breast tumor. The present disclosure also provides a cancer risk score to determine whether a subject has low risk, intermediate risk, or high risk of developing cancer, thereby permitting selection of appropriate therapies to treat the subject. The present disclosure addresses the need for improved diagnostic assessment of early hyperplastic lesions, the presence of which in a subject is a significant indicator that a subject will eventually develop invasive breast cancer.

Abstract: A method for separating cells capable of producing target antigen-specific monoclonal antibodies (TASMAs) wherein a cell group including antibody-producing cells is immobilized using a reversible crosslinking agent having cell membrane-permeating properties. The immobilized cell group is subjected to cell membrane dissolution using a surface active agent; and the cell group is reacted with a labeling target antigen. In the stained cell group a that has reacted with the labeling target antigen is separated. A method to produce TASMAs by separating mRNA from the cell separated using the method; preparing cDNA and preparing antigen-specific monoclonal antibodies or fragments thereof from the prepared cDNA. Also provided are a method whereby at least one cell capable of producing TASMAs is separated and a method whereby said antibodies can be produced by using the separated cell.

Abstract: Reagents comprising MS active, fluorescent molecules with an activate functionality for reaction with amines useful in rapid tagging of biomolecules such as N-glycans, proteins, peptides, and amino acids, and uses thereof are taught and described. These MS active, fluorescent molecules may have three functional components such as a tertiary amino group or other MS active atom, a highly fluorescent moiety, and a functional group that rapidly reacts with amines.

Abstract: Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more.

Abstract: The invention concerns a method of analyzing the content of drops, involving then following step: providing a plurality of drops (6) contained in a carrier fluid, at least one of the drops (6) comprising at least one aggregate (10) of particles defining an object extending along a main axis, at least some of the drops (6) containing at least one target element capable of attaching to the aggregate (10). The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate (10) is measured.

Abstract: A protein assay method, including: 1) dissolving 4-hydroxybenzenesulfonic acid in an ethanol, methanol, or acetonitrile aqueous solution to prepare a hydrolysis reagent, adding a protein sample and the hydrolysis reagent to a hydrolysis tube, and uniformly mixing the protein sample and the hydrolysis reagent, charging argon or nitrogen into the hydrolysis tube to remove dissolved oxygen, sealing and drying the hydrolysis tube, and hydrolyzing the protein sample; 2) cooling the hydrolysis tube to room temperature, filtering and adding a resulting hydrolysate to a volumetric flask, washing the hydrolysis tube and a filter paper, collecting and adding a resulting washing solution to the volumetric flask to a constant volume; 3) drawing a hydrolysate solution from the volumetric flask, completely drying the hydrolysate solution to yield a solid product; and 4) diluting the solid product using a diluent, and analyzing amino acids of the solid product.

Abstract: The invention concerns the field of detecting and quantifying misfolded proteins/peptides. In particular the detection and quantification of misfolded proteins/peptides in body fluids, on cell surfaces of humans and mammals, the detection of misfolded proteins/peptides in reagents to be tested for scientific research and/or diagnostic use and in pharmaceutical medication or their additives and it concerns as well the removal of misfolded proteins/peptides from reagents to be tested for scientific research and/or for diagnostic purposes and from pharmaceutical medication or their additives.

Abstract: The present application discloses stability-indicating potency assays for influenza vaccines.

Abstract: The present invention relates to an isolated naturally-occurring soluble truncated IL-23R? protein, which is a translated protein resulting from a mRNA splice variant of IL-23R?. The soluble IL-23R? proteins (e.g., ?9 and ?8,9) represents a novel soluble IL-23R? protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that ?9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23R? protein. More importantly, the present invention provides an utility application of the ?9 and ?8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, ?9 and ?8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of ?9 and ?8,9 in treating a human patient inflicted with Crohn's disease.