Patents Issued in September 24, 2019
  • Patent number: 10421801
    Abstract: Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: September 24, 2019
    Inventors: Ananda M Chakrabarty, Tapas K Das Gupta, Vasu Punj, Olga Zaborina, Yoshinori Hiraoka, Tohru Yamada
  • Patent number: 10421802
    Abstract: The invention provides polypeptides (e.g., antibodies) and fusion proteins that target a epitope in the receptor binding domain (RBD) of the spike (S) glycoprotein of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The polypeptides and fusion proteins can be used to treat and prevent MERS-CoV infection in mammals.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: September 24, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Veritech Limited
    Inventors: Dimiter S. Dimitrov, Tianlei Ying, Tina W. Ju, Kwok Yung Yuen
  • Patent number: 10421803
    Abstract: The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: September 24, 2019
    Assignees: The Rockefeller University, California Institute of Technology
    Inventors: Michel Nussenzweig, Pamela J. Bjorkman, Louise Scharf, Johannes Scheid
  • Patent number: 10421804
    Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the ZIKV for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: September 24, 2019
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Christos Kyratsous, William Olson, Peter Mason
  • Patent number: 10421805
    Abstract: The invention provides an antibody or antigen binding fragment thereof capable of binding to the antigen binding pocket of the AP33 antibody, wherein said antibody or antigen binding fragment thereof comprises VL CDR1 (L1), VL CDR2 (L2), and VL CDR3 (L3) consisting of the amino acid sequences of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:23 respectively, and comprises VH CDR1 (H1), VH CDR2 (H2), and VH CDR3 (H3) consisting of the amino acid sequences of SEQ ID NO:24, SEQ ID NO:25, and SEQ ID NO:26 respectively. The invention also provides compositions, methods, nucleic acids and uses.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: September 24, 2019
    Assignee: United Kingdom Research and Innovation
    Inventors: Arvind Patel, Ania Owsianka
  • Patent number: 10421806
    Abstract: The present disclosure provides anti-Salmonella antibodies or antibody fragments, such as camelid single domain antibodies (VHHs), along with associated nucleic acids, host cells and phages. Methods of reducing the presence of Salmonella in an animal or an animal environment, methods and formulations for treating Salmonella infection, and methods of detecting Salmonella are also described.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: September 24, 2019
    Assignee: ABCELEX TECHNOLOGIES INC.
    Inventors: Ali Riazi, Rashida Williams, Dea Shahinas, Saeid Babaei, Zhun Yan
  • Patent number: 10421807
    Abstract: A cell-based assay for assessing the functional activity of a canine or feline IL-31 inhibitor candidate is provided. Such a canine or feline IL-31 inhibitor candidate can be an isolated antibody that specifically binds to at least one of canine Interleukin-31 (IL-31) or feline IL-31. Such antibodies can be in the form of diagnostic and/or veterinary compositions useful for treating a pruritic and/or allergic condition in dogs or cats.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: September 24, 2019
    Assignee: Zoetis Services LLC
    Inventors: Andrea Joy Gonzales, Gregory Fici, Gary Francis Bammert, Steven Alan Dunham
  • Patent number: 10421808
    Abstract: The present disclosure provides Bak binding proteins that change the conformation of Bak and uses thereof.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: September 24, 2019
    Assignee: The Walter and Eliza Hall Institute of Medical Research
    Inventors: Amber Alsop, Khatira Anwari, Grant Dewson, Sweta Iyer, Ruth Kluck
  • Patent number: 10421809
    Abstract: This invention relates generally to antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and to methods of using the anti-TLR4 antibodies in methods of preventing transplant rejection and/or prolonging survival of transplanted biological material.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: September 24, 2019
    Assignee: NovImmune SA
    Inventors: Marie Kosco-Vilbois, Katrien De Graaf, Thierry Berney, Laurianne Santa Giovannoni, Domenic Bosco
  • Patent number: 10421810
    Abstract: Chimeric antigen receptors containing tumor necrosis factor receptor superfamily member transmembrane domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: September 24, 2019
    Assignee: LENTIGEN TECHNOLOGY, INC.
    Inventors: Rimas Orentas, Dina Schneider, Boro Dropulic
  • Patent number: 10421811
    Abstract: Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions. In various aspects, stable coformulations of the anti-PD-L1 antibody durvalumab (MEDI4736) and the anti-CTLA-4 antibody tremelimumab are provided.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: September 24, 2019
    Assignee: MEDIMMUNE, LLC
    Inventors: Jiali Du, Ambarish Shah
  • Patent number: 10421812
    Abstract: Aspects of the present disclosure relate to binding agents (e.g., antibodies and antigen binding fragments) that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. In some embodiments, immunological assay methods utilizing isoform-specific antibodies or antigen binding fragments that bind sFlt1 isoforms are provided for assessing biological samples obtained from pregnant subjects, e.g., for purposes of evaluating preeclampsia status in the subject.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: September 24, 2019
    Assignee: University of Massachusetts
    Inventors: Teresa Broering, Colby Souders, Gregory Babcock, Naomi Boatright
  • Patent number: 10421813
    Abstract: The invention provides anti-oncostatin M receptor-? (OSMR) antigen binding proteins, e.g., antibodies and functional fragments, derivatives, muteins, and variants thereof. OSMR antigen binding proteins interfere with binding of OSM and/or IL-31 to OSMR. In some embodiments, anti-OSMR antigen binding proteins are useful tools in studying diseases and disorders associated with OSMR and are particularly useful in methods of treating diseases and disorders associated with OSMR and binding of OSM and/or IL-31 to OSMR.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: September 24, 2019
    Assignee: Kiniksa Pharmaceuticals, Ltd.
    Inventors: Heather A. Arnett, Sabine S. Escobar, Chadwick T. King, Ai Ching Lim, Saravanakumar Narayanan, Paul H. Weinreb, Nels E. Pederson
  • Patent number: 10421814
    Abstract: The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 24, 2019
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Graham Craggs, Karine Jeannine Madeleine Herve, Diane Marshall
  • Patent number: 10421815
    Abstract: The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: September 24, 2019
    Assignee: Pfizer Inc.
    Inventors: Shu-Hui Liu, Flavia Mercer Pernasetti, Wei-Hsien Ho
  • Patent number: 10421816
    Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: September 24, 2019
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Ralph Adams, Emma Dave, David Paul Humphreys
  • Patent number: 10421817
    Abstract: An isolated monoclonal antibody that specifically binds human Claudin 18.2. A nucleic acid molecule encoding the antibody, an expression vector, a host cell and a method for expressing the antibody are also provided. The present invention further provides an immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus and a pharmaceutical composition comprising the antibody, as well as a diagnostic or treatment method using an anti-Claudin 18.2 antibody of the invention.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: September 24, 2019
    Assignee: BEIJING MABWORKS BIOTECH CO., LTD.
    Inventors: Wenqi Hu, Jiangmei Li, Xia Wang, Feng Li
  • Patent number: 10421818
    Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: September 24, 2019
    Assignee: PIERRE FABRE MEDICAMENT
    Inventors: John Lippincott, Edward Thein Htun Van Der Horst, Sun Young Kim, Leonard G. Presta
  • Patent number: 10421819
    Abstract: The present describes monoclonal antibody to MUC1*.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: September 24, 2019
    Assignee: Minerva Biotechnologies Corporation
    Inventors: Cynthia C. Bamdad, Sanjeev Mahanta
  • Patent number: 10421820
    Abstract: Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 breast cancer survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells. Thus, embodiments of the invention find application in the field of cancer therapy.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: September 24, 2019
    Assignee: University Of New York
    Inventors: Douglas S. Conklin, Xianhui Wang, Leila Kokabee
  • Patent number: 10421821
    Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: September 24, 2019
    Assignee: Genentech, Inc.
    Inventors: Robert F. Kelley, Daniel K. Kirchhofer, Joyce Lai, Chingwei V. Lee, Wei-Ching Liang, Michael T. Lipari, Kelly M. Loyet, Tao Sai, Menno Van Lookeren Campagne, Yan Wu, Germaine Fuh
  • Patent number: 10421822
    Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: September 24, 2019
    Assignee: Genetech, Inc.
    Inventors: Robert F. Kelley, Daniel K. Kirchhofer, Joyce Lai, Chingwei V. Lee, Wei-Ching Liang, Michael T. Lipari, Kelly M. Loyet, Tao Sai, Menno Van Lookeren Campagne, Yan Wu, Germaine Fuh
  • Patent number: 10421823
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: September 24, 2019
    Assignee: AMGEN INC.
    Inventors: Hailing Hsu, Ming Zhang, Gunasekaran Kannan, Frederick W. Jacobsen, Wayne Tsuji
  • Patent number: 10421824
    Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: September 24, 2019
    Assignee: AMGEN INC.
    Inventors: Hailing Hsu, Ming Zhang, Gunasekaran Kannan, Frederick Jacobsen, Wayne Tsuji
  • Patent number: 10421825
    Abstract: The present invention relates to polymers functionalized by terminal groups that have, at the chain ends thereof, an ether-containing group of the formula (V) —[—O-A-O?]nXn+??(V) where A is a divalent organic moiety, and X is either H, and n=1, or X is a metal and n is an integer of 1 to 4.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: September 24, 2019
    Assignee: ARLANXEO DEUTSCHLAND GMBH
    Inventor: Norbert Steinhauser
  • Patent number: 10421826
    Abstract: A method for providing a resin having minimal discoloration comprises combining, in a reactor or a reactor vessel, monomers, an emulsifier or surfactant, and an initiator in solution to form a polymeric latex; directing the polymeric latex into a storage system comprising a storage vessel; maintaining the latex in the storage vessel for an aging time and ensuring that the polymeric latex exhibits less than 1000 CFU/ml of biological growth according to ASTM D 5465-93 (2012) upon completion of the aging time; and coagulating the polymeric latex, wherein the polymeric latex is exposed to a mixture of water and a coagulant and filtered to provide a resin.
    Type: Grant
    Filed: February 15, 2016
    Date of Patent: September 24, 2019
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Shi Wang, Jianhua Xu, Vern Lowry
  • Patent number: 10421827
    Abstract: A method for manufacturing a filter membrane for inhibiting microorganisms includes the following steps: obtaining a nano-zinc precursor and dissolving it into water, adding at least one reducing agent and interfacial agent to the water, thereby reducing zinc ions of the nano-zinc precursor to zinc particles so as to form liquid having nano-zinc particles; respectively placing the liquid having nano-zinc particles and a polymer material into plastic masterbatch process equipment, respectively volatilizing the fluid having nano-zinc particles and polymer material through the plastic masterbatch process equipment, performing air extraction and mixing by the plastic masterbatch process equipment, and adding at least one grafting agent to perform a mixed graft link, allowing the nano-zinc particles and polymer material to be linked together stably so as to form a plastic masterbatch having nano-zinc particles; and making the plastic masterbatch into a filer membrane through film making equipment.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: September 24, 2019
    Assignees: MIPTECH CO., LTD.
    Inventors: Kuo-Chih Hsieh, Chien-Ying Tsai
  • Patent number: 10421828
    Abstract: Provided is a resin composition for a solid polymer fuel cell sealing material, the resin composition including a copolymer resin having a weight average molecular weight of 150,000 or more and formed by copolymerizing raw material components including: (a1) 5% by mass or more of styrene; and (b) 20% by mass or less of glycidyl (meth)acrylate. Preferably, the raw material components are configured to further include (c) one or more kinds of other polymerizable monomers selected from a hydroxyalkyl (meth)acrylate and an alkyl (meth)acrylate.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: September 24, 2019
    Assignee: PANAC Co., Ltd.
    Inventor: Shingo Motoike
  • Patent number: 10421829
    Abstract: Catalyst systems and methods for making and using the same. A method of methylating a catalyst composition while substantially normalizing the entiomeric distribution is provided. The method includes slurrying the organometallic compound in dimethoxyethane (DME), and adding a solution of RMgBr in DME, wherein R is a methyl group or a benzyl group, and wherein the RMgBr is greater than about 2.3 equivalents relative to the organometallic compound. After the addition of the RMgBr, the slurry is mixed for at least about four hours. An alkylated organometallic is isolated, wherein the methylated species has a meso/rac ratio that is between about 0.9 and about 1.2.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: September 24, 2019
    Assignee: Univation Technologies, LLC
    Inventors: Francis C. Rix, Alexander D. Todd, C. Jeff Harlan
  • Patent number: 10421830
    Abstract: The present invention relates to novel materials particularly useful for ophthalmic applications and methods for making and using the same. More particularly, the present invention relates to relatively soft, optically transparent, foldable, high refractive index materials particularly suited for use in the production of intraocular lenses, contact lenses, and other ocular implants and to methods for manufacturing and using the same.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: September 24, 2019
    Assignee: KEY MEDICAL TECHNOLOGIES, INC.
    Inventors: Khalid Mentak, Anthony Keslinke, Kevin Phan
  • Patent number: 10421831
    Abstract: A curable composition for making polyisocyanurate comprising products obtained by combining and mixing at an isocyanate index of at least 100 at least a polyisocyanate composition, a polytetrahydrofuran polyol (P-THF) having average molecular weight in range 1000-5000 g/mol as toughening agent and diols having an average molecular weight <1000 g/mol.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: September 24, 2019
    Assignee: HUNTSMAN INTERNATIONAL LLC
    Inventor: Steve Andre Woutters
  • Patent number: 10421832
    Abstract: Tertiary amine catalysts having isocyanate reactive groups capable of forming thermally stable covalent bonds able to withstand temperatures from 120° C. and higher and up to 250° C. are disclosed. These catalyst can be used to produce polyurethane foam having the following desirable characteristics: a) very low chemical emissions over a wide range of environmental conditions and isocyanate indexes (e.g., indexes as low as 65 but higher than 60); b) sufficient hydrolytic stability to maintain the catalyst covalently bound to foam without leaching of tertiary amine catalyst when foam is exposed to water or aqueous solutions even at temperatures higher than ambient (temperature range 25° C. to 90° C.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: September 24, 2019
    Assignee: Evonik Degussa GmbH
    Inventors: Juan Jesus Burdeniuc, Torsten Panitzsch, Renee Jo Keller
  • Patent number: 10421833
    Abstract: Use of compounds selected from polyols derived from dimer fatty acids and/or dimer fatty alcohols as toughening agent in a process for making polyisocyanate polyaddition reaction products, in particular for polyisocyanate polyaddition reaction products having a hardblock >40% and a process for making said products.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: September 24, 2019
    Assignee: HUNTSMAN INTERNATIONAL LLC
    Inventors: Hugo Verbeke, Hans Godelieve Guido Verbeke, Christian Esbelin, Ainara Astaburuaga Gutierrez
  • Patent number: 10421834
    Abstract: Provided is a curable composition capable of giving a lens that has excellent transfer accuracy from a mold and offers heat resistance and optical properties at excellent levels. The curable composition according to the present invention for lens formation contains a cycloaliphatic epoxide (A) represented by Formula (a), a cationic-polymerization initiator (B), and a polysiloxane (C) represented by Formula (c). The curable composition contains the polysiloxane (C) in an amount of 0.01% to 5% by weight based on the total amount of the curable composition. The curable composition according to the present invention for lens formation may further contain a siloxane compound (D) containing two or more epoxy groups per molecule.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: September 24, 2019
    Assignee: DAICEL CORPORATION
    Inventors: Takeshi Fujikawa, Takashi Kubo
  • Patent number: 10421835
    Abstract: The invention provides a polyester film for sealant use. The polyester film contains a polyester resin having ethylene terephthalate as a main structural component and including one or more monomer components that may serve as amorphous components so that the total amount of the monomer components are not less than 12 mol % and not more than 30 mol % among total monomer components. The polyester film is uniaxially or biaxially stretched, and has a particular heat-sealing strength and crystal melting heat capacity. The invention also provides a laminate including as at least one layer of the polyester film for sealant use, as well as a packaging bag that utilizes the laminate.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: September 24, 2019
    Assignee: TOYOBO CO., LTD.
    Inventors: Masayuki Haruta, Kazuya Hiro
  • Patent number: 10421836
    Abstract: The present invention relates to a purifying apparatus for polycarbonate polyols, especially for removal of cyclic alkylene carbonates, comprising an evaporation unit (1) provided with a heater (10) and having an inlet (6) disposed at the top end thereof and a bottoms vessel (11), and a stripping column (2) connected downstream of the evaporation unit (1) and having a top (21) and a bottom (23), wherein a feed (5) for the polycarbonate polyol to be purified opens into the inlet (6) to the evaporation unit (1) and a gas outlet line (12) and a connecting line which opens into the top (21) of the stripping column (2) and is equipped with a pump (18) depart from the evaporation unit (1), and wherein a gas inlet line (24) for an inert gas opens into the bottom (23) of the stripping column (2) and a product line (27) for the purified polycarbonate polyol departs from the bottom (23) of the stripping column (2) and a gas outlet line (25) departs from the top (21) of the stripping column (2).
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: September 24, 2019
    Assignee: COVESTRO DEUTSCHLAND AG
    Inventors: Jörg Hofmann, Stefanie Braun, Kai Laemmerhold, Matthias Wohak, Cyrus Ahmadzade-Youssefi, Jürgen Bausa
  • Patent number: 10421837
    Abstract: The present disclosure is drawn to polymeric amine synergist compositions. The polymeric amine synergist composition can include a polymeric amine synergist including an aminobenzene modified with a polyether chain connecting to the aminobenzene through an ether linkage. The polymeric amine synergist can be present in a reaction product mixture with either i) an aminophenol, or ii) a carbonate base.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: September 24, 2019
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Zhang-Lin Zhou, Rodney David Stramel, Gregg A. Lane
  • Patent number: 10421838
    Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: September 24, 2019
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Jon McKannan, Samuel P. McManus
  • Patent number: 10421839
    Abstract: One of the purposes of the present invention is to provide an aminoalkyl group-containing siloxane, in particular an aminoalkyl group- and polyoxyalkylene group-containing siloxane, in which an amount of a cyclic siloxane as an impurity contained is decreased, and a method for preparing the same.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: September 24, 2019
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Yuji Ando
  • Patent number: 10421840
    Abstract: Disclosed herein is a silicone-modified polyimide resin composition of solvent free type. The composition is suitable for use as an adhesive and a coating material which are capable of hardening upon irradiation with ultraviolet rays and/or visible rays. Also, it is saved from drooling even in the case of light filling with an inorganic compound and it is saved from bubble entrapment and nonuniformity at the time of application with heavy filling. It further exhibits good moldability due to its thixotropic properties. Moreover, it exhibits improved adhesion to polyolefin resins without impairing the past properties. Finally, it gives rise to a cured product which is not excessively hard, with a low elastic modulus, despite filling with an inorganic compound. The composition of the present invention includes components (A) to (B) listed below and is characterized by being fluid at 25° C.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: September 24, 2019
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Hatsuhiko Hattori, Yoshinori Yoneda, Tomoya Kanai
  • Patent number: 10421841
    Abstract: The present invention relates to a method for producing silazane-siloxa copolymers and the use of such copolymers, particularly in LEDs.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: September 24, 2019
    Assignee: AZ Electronic Materials (Luxembourg) S.a.r.l.
    Inventors: Ralf Grottenmüller, Abraham Casas Garcia-Minguillan, Fumio Kita, Dieter Wagner
  • Patent number: 10421842
    Abstract: A preparation method of a rubber composition for a tire assures that good processability can be obtained even if a silane coupling agent having a mercapto group is blended. The preparation method of a rubber composition for a tire is characterized by initiating kneading of a rubber component and a compound represented by the following formula (1) before kneading the rubber component and a silane coupling agent having a mercapto group. (Wherein each of R1 to R4 independently represents a straight-chain or branched chain alkyl group having 1 to 18 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: September 24, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Tatsuhiro Tanaka, Takayuki Nagase, Keiji Ikeda
  • Patent number: 10421843
    Abstract: Amino acid-based poly(ester amide) (PEA) macromers (e.g., functional PEA macromers) and methods for preparing amino acid-based poly(ester amide) (PEA) macromers. The functional PEA macromers can comprise functional groups such as hydroxyl, amine, sulfonic acids, carboxyl, thiol and acryloyl at the two terminuses of the PEA macromers. The content of the terminal functional groups on the macromers can be precisely controlled by adjusting the molar ratio of reactive monomers. The resulting versatility of these new functional PEA macromers can be used to fabricate a wide range of PEAs and PEA hybrid derivatives with very different chemical, physical, mechanical, thermal and biological properties. The functional PEA macromers can also be polycondensed into forming block PEA polymers.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: September 24, 2019
    Assignee: Cornell University
    Inventors: Chih-Chang Chu, Mingxiao Deng
  • Patent number: 10421844
    Abstract: A self-assembled monolayer is formed on the surface of a molded article without roughening the surface of the molded article to thereby perform treatment for preventing a biochemical substance from being adsorbed, for example, on a microchip substrate, and imparting functionality of immobilizing a biofunctional molecule thereto. The surface of a cyclic olefin resin molded article, for example, a microchip substrate, is irradiated with vacuum ultraviolet light having a center wavelength of 172 nm from an excimer lamp to activate a portion serving as a flow channel in the substrate. Next, the molded is immersed in a tank filled, for example, with a fluorine compound solution, and a SAM film that is a self-assembled monolayer is formed on the surface activated by ultraviolet radiation.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: September 24, 2019
    Assignee: USHIO DENKI KABUSHIKI KAISHA
    Inventors: Masaki Miura, Shinji Suzuki, Kinichi Morita, Toshikazu Kawaguchi, Katsuaki Shimazu
  • Patent number: 10421845
    Abstract: A method of manufacturing a polishing pad includes producing an urethane prepolymer having a viscosity of 20,000 cps (at 25° C.) to 40,000 cps (at 25° C.) by mixing a plurality of polymers, mixing the urethane prepolymer with an inert gas and a low-boiling blowing agent having a boiling point of 60° C. to 150° C., and manufacturing a polishing layer including porous pores by causing a mixture produced at the mixing to be subjected to gelation and curing in a predetermined cast.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: September 24, 2019
    Assignee: KPX CHEMICAL CO., LTD.
    Inventors: Seung-Geun Kim, Hak-Su Kang, Jeong-Seon Choo, Dae-Han Jung, Gi-Young Park
  • Patent number: 10421846
    Abstract: The present invention aims to solve the above mentioned problems by providing a new azeotrope-like composition that can be used for a wide range of industrial purposes. The provision of an azeotrope-like composition including 93.0-99.0 weight percent Z-1,1,1,4,4,4-hexafluoro-2-buteine and 0.1-7 weight percent isopropanol.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: September 24, 2019
    Assignee: DUPONT-MITSUI FLUOROCHEMICALS CO., LTD
    Inventors: Hideaki Kikuchi, Takanori Matsumoto
  • Patent number: 10421847
    Abstract: A nanoporous open-cell foam or wick structure and method for production are disclosed. The nanoporous foam or wick structures are produced from, for example, thermoplastic or thermoset polymer gels in which a gelation solvent is removed so as to preserve an expanded monolithic gel structure consisting of intertwined and or chemically crosslinked polymer molecular fibrils. The nanoporous foam or wick may encompass a stand-alone structure, or be incorporated in to microporous open cell foams or wick materials converting them in to nanoporous cellular materials having a bipore structure. Such produced nanoporous polymer materials have unique properties that may be exploited for making high performance capillary pump loop or heat pipe thermal management systems, low-boiloff slosh-less cryogen storage vessels and superior insulation materials for systems operating under ambient and elevated pressure conditions.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: September 24, 2019
    Assignee: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: John A. Starkovich
  • Patent number: 10421848
    Abstract: Unexpectedly unique and environmentally friendly composite material structures, storage articles fabricated therefrom, and related methods. The composite structure includes at least one or more fiber-containing layers, such as fiberboard or other layers having fibers from natural and/or synthetic sources, and one or more mineral-containing layers. The mineral-containing layer(s) comprises a thermoplastic bonding agent fixing the mineral particles in place. The fiber-containing layer(s) and mineral-containing layer(s) can be shaped, sized, and manufactured such that the composite structure formed therefrom is capable of being machined to form the storage article. The composite structure can be repulped and recycled without the use of dispersions, emulsions, or aqueous solutions. Further, the composite reduces layer mass requirements for heat seal, barrier, and fiber adhesion compared to polymer layers.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: September 24, 2019
    Assignee: Smart Planet Technologies, Inc.
    Inventor: Christopher R. Tilton
  • Patent number: 10421849
    Abstract: A catalyst complex for catalysis of degradation of a polymer material is described. Said complex comprises a magnetic particulate body containing iron oxide at its surface with an average diameter of 150-450 nm, and a plurality of catalytic groups grafted onto the iron oxide surface of the magnetic particulate body, which catalytic groups comprise a bridging moiety and a catalyst entity, wherein the bridging moiety comprises a functional group for adhesion or bonding to the iron oxide surface and a linking group towards the catalyst entity, and wherein the catalyst entity comprises a positively charged aromatic heterocycle moiety, and a negatively charged moiety for balancing the positively charged aromatic moiety.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: September 24, 2019
    Assignee: Ioniqa Technologies B.V.
    Inventors: Sonja Irene-Marie Reginalde Castillo, Susanne Van Berkum, Vincent Gertudis Antonius Philippi, Joost Robert Wolters
  • Patent number: 10421850
    Abstract: Mixtures containing dipentyl terephthalate, dinonyl terephthalate and pentyl nonyl terephthalate can be prepared with a predetermined distribution of the individual esters in the mixture, and used as plasticizers.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: September 24, 2019
    Assignee: Evonik Degussa GmbH
    Inventors: Benjamin Woldt, Florian Sebastian Boeck, Michael Grass, Harald Haeger