Abstract: A connector assembly for connecting external power sources to an implanted medical device enables continual supply of electrical power to the implanted medical device during replacement of an external power source. A connector assembly includes a distal driveline contact assembly, a first driveline contact assembly, and a second driveline contact assembly. The second driveline contact assembly is connectable to the distal driveline contact assembly prior to disconnection of the first driveline contact assembly from the distal driveline contact assembly.

Abstract: Disclosed herein is a collapsible and self-expanding cannula for a percutaneous heart pump. The collapsible and self-expanding cannula comprises an open proximal end, an open distal end, and an elongate fluid-impermissible wall structure that includes a first balloon film, a cannula strut, and a second balloon film. The first balloon film is disposed on an interior surface of the cannula, the second balloon film is disposed on the exterior surface of the cannula, and the cannula strut is between the two balloon films. Together they form an integrated hybrid structure upon thermal fusion bonding. Also disclosed herein is a method of manufacturing the collapsible and self-expanding cannula.

Abstract: A method is provided for the transcatheter delivery of an intracorporeal device and includes establishing a device delivery pathway in a patient. The device delivery pathway extends at least from an entry point into the patient to an exit point from the patient. A method is also provided for the transcatheter retrieval of an intracorporeally implanted device and includes establishing a device delivery pathway in a patient, wherein the device delivery pathway extends at least from an entry point into the patient to an exit point from the patient. A delivery device is also provided for the transcatheter delivery of an intracorporeal device through a device delivery pathway in a patient, the delivery device comprising a catheter comprising a radial separation mechanism, or a delivery catheter and detachably coupling with an intracorporeal device.

Abstract: Systems and devices for improving wireless power transmission are disclosed herein. The system can include an implantable medical device that can include an energy storage component and a secondary coil electrically coupled to the energy storage component. The system can include a charging device. The charging device can include a flexible housing defining an internal volume, a resonant circuit, a plurality of sensors coupled to the primary coil, and processor. The resonant circuit can include a deformable primary coil located within the internal volume of the housing. The processor can determine a deformation of the primary coil based on at least one signal received from at least one of the plurality of sensors.

Abstract: An external controller assembly for a medical device implanted in a patient includes an external controller and an external driveline assembly. The external controller includes an external controller display viewable by the patient. The external driveline assembly includes an external driveline cable and an external driveline distal connector. The external driveline cable is connected to the external driveline distal connector and the external controller. The external driveline cable accommodates positioning of the external driveline distal connector, by the patient, for simultaneous viewing of the external driveline distal connector and the external controller display by the patient. The external driveline distal connector is adapted to be connected to the distal driveline proximal connector by the patient. The external driveline distal connector is adapted to be disconnected from the distal driveline proximal connector by the patient.

Abstract: A blood processing apparatus includes an optional heat exchanger and a gas exchanger disposed within a housing. In some instances, the gas exchanger can include a screen filter spirally wound into the gas exchanger such that blood passing through the gas exchanger passes through the screen filter and is filtered by the spirally wound screen filter a plurality of times.

Abstract: A biological component treatment cassette (blood component collection cassette (28)) is configured to be attachable to a separation device (centrifugal separation device (14)), and a flow path (42) is formed in an interior portion thereof. The biological component treatment cassette includes a wall portion forming a part of the flow path (42, and is equipped with pump action members (first and second pump action members (58, 66)) formed of a soft material and which are pressed by pumps of the separation device. The pump action members include pump pressed portions (first pump pressed portions (58a), second pump pressed portions (66a)).

Abstract: A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Abstract: A plasmapheresis bowl for the separation and collection of plasma includes a core and a feed tube that increase the bowl efficiency and reduce foaming within the plasma. The core may have a cylindrical body and a ledge located within the interior of the core. The ledge extends radially inward from the core and defines, at least partially, a collection chamber within the plasmapheresis bowl. The core also has ribs that extend above the top of core body and create flow paths that allow fluid to enter the interior of the cylindrical body and collection chamber. The feed tube has a flow path extending through it that fluidly connects an inlet port on the plasmapheresis centrifuge. A first skirt member on the feed tube has a smooth angled surface that helps to reduce foaming.

Abstract: A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that the first internal pressure becomes equal to the second internal pressure in a state in which operation of a collection and returning pump (100) is stopped during at least one of a collection operation and a returning operation of a first cycle.

Abstract: A process includes removing air bubbles from extracorporeal blood via chemical entrapment of nitrogen (N2) gas.

Abstract: A process includes removing air bubbles from extracorporeal blood via chemical entrapment of nitrogen (N2) gas.

Abstract: Apparatus and methods for controlled arterial/venous access are provided. The apparatus and methods may include a section of tubing anastomosed to a bodily lumen. A lumen clamping means may utilize a clamp manipulator to effectively seal the tubing, and the manipulator may be operated by two fingers. A needle receptor may be utilized, and the receptor may utilize a rotating member to guide a needle inserted from outside the body, in order ensure accurate placement into a channel. The channel may be in liquid communication with the tubing. The manipulator and the needle receptor may be palpable from outside the body.

Abstract: A method for separating cells in a biofluid includes pretreating the biofluid by introducing an additive, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel. A system for microfluidic cell separation, capable of separating target cells from non-target cells in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic cell separation includes a microfluidic separation channel connected to an acoustic transducer, a source of an additive, and instructions for use.

Abstract: A biological component treatment cassette (blood component collection cassette (28)) is configured to be attachable to a separation device (centrifugal separation device (14)) adapted to separate a biological component from a liquid containing at least one biological component, and a flow path (42) is formed in an interior portion thereof. The biological component treatment cassette includes a sheet-shaped cassette main body (40), and a first pump action tube (58), both ends of which are connected to the flow path (42) of the cassette main body (40), together with a portion thereof protruding from an outer peripheral edge portion of the cassette main body (40), and which is made from a soft material that is pressed by a pump (80) of a separation device.

Abstract: A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit (110) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit (112).

Abstract: A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.

Abstract: A femoral hip joint spacer including a prosthesis body having a ball head with a sliding surface, a neck, a collar and a stem. A fastening area is arranged on the stem. The femoral hip joint spacer further has a first connector for feeding a medical irrigation liquid into the body, a second connector for draining the irrigation liquid from the body, and an irrigation liquid inlet opening. The first connector is connected in a liquid-conveying manner to the irrigation liquid inlet opening and an irrigation liquid outlet opening. The second connector is connected in a liquid-conveying manner to the irrigation liquid outlet opening, an irrigation liquid discharge opening and an irrigation liquid intake opening. The irrigation liquid discharge opening is connected inside the body to the irrigation liquid inlet opening and the irrigation liquid intake opening is connected inside the body to the irrigation liquid outlet opening.

Abstract: Disclosed herein is a temporary knee spacer system for the temporary replacement of a knee joint, which is designed for the interim phase of two-stage septic revisions of knee joint total endoprostheses. The knee spacer system can be used in particular with two-phase septic revisions with which two or more microbial germs are the cause of an infection of the knee joint total endoprosthesis and the surrounding tissue.

Abstract: Systems, methods, and apparatuses are provided for delivering reduced pressure to a subcutaneous tissue site, such as a bone tissue site. In one instance, a manifold for providing reduced pressure to a subcutaneous tissue includes a longitudinal manifold body formed with at least one purging lumen and a reduced-pressure lumen. The manifold further includes a plurality of manifolding surface features or slits formed on the second, tissue-facing side of the longitudinal manifold body and a plurality of apertures formed in the longitudinal manifold body on the second, tissue-facing side. The plurality of apertures fluidly couple the reduced-pressure lumen and the manifolding surface features or slits. The manifold further includes an end cap fluidly coupling the reduced-pressure lumen and the at least one purging lumen. Other systems, apparatuses, and methods are presented.

Abstract: The disclosure concerns an apparatus for generating at least one injection parameter for a contrast agent injector. The apparatus includes a first data interface for receiving patient data and a second data interface for connection to a contrast agent injector. The apparatus also includes a data processing unit for generating at least one injection parameter in dependence on patient data received by way of the first data interface and for outputting the injection parameter at the second data interface. The disclosure further concerns a system comprising such an apparatus as well as a method therewith.

Abstract: A device for the thorough delivery of liquid medicine in an intravenous (IV) delivery system. The device consists of a negative pressure chamber filled with saline solution that is used to flush all of the residual liquid medicine from a secondary liquid medicine delivery tube. The negative pressure chamber sits below the drip chamber attached to the secondary medicine bag and is attached to the secondary medicine delivery tube in such a way that when the liquid medicine from the delivery tube has flowed below the negative pressure chamber, the negative pressure chamber releases the stored saline to flush the liquid medicine from the secondary liquid medicine delivery tube.

Abstract: A patency device for catheter assemblies and other elongate tubular devices used for establishing access to an interior body portion of a patient is disclosed. The patency device establishes and preserves patency of one or more lumens defined by the catheter assembly by providing impulses of positive pressure to fluid disposed in the lumen of the catheter assembly. In one embodiment, the patency device comprises a fluid reservoir configured to provide a fluid path to at least one lumen of the catheter assembly, and a pressure input portion. The pressure input portion is configured to provide pressure for one or more impulses of positive pressure to a fluid disposed within the lumen. The impulses are configured to dislodge occlusions that may have formed in the lumen. A negative pressure can then be provided to the lumen to aspirate the occlusion.

Abstract: Protein detection kit usable with implanted infusion pumps. The kit includes at least one container containing a protein-detecting composition and having an interface for allowing fluid to be introduced and a visual indicating mechanism for providing a visual indicator indicative of protein detection.

Abstract: A digital biomedical device includes a substrate forming a reservoir, a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir, and a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir.

Abstract: Flow controllers for intravenous (IV) tubing are provided. A flow controller may include first and second structural members defining a cavity therebetween for a portion of the tubing, wherein the first structural member is linearly slidable along a length of the tubing to compress at least part of the portion of the tubing to control flow of a medical fluid through the tubing. A flow controller may include a first ramped wedge structure, a second ramped wedge structure configured to slide over the first ramped wedge structure to compress a portion of the IV tubing disposed between the first ramped wedge structure and the second ramped wedge structure, a yoke having a linear slot, a wheel having a pin that is radially separated form a center of the wheel and is slidably disposed in the linear slot, and a transfer structure coupled to the yoke and the first ramped wedge structure. IV sets that include a flow controller are also provided.

Abstract: A valve for use in connection with microfluidic devices includes a safety feature such that flow is controlled even in the case of a loss of power, thus having applications in critical applications such as the precise delivery of drugs over time. The valve may be used in connection with multiple tubes delivering drugs, and may be used with a pump, such as an electrochemical pump, to provide the force to move the fluids containing drugs for delivery. In certain applications, more than one medicine may be delivered and metered independently using a single pump with multiple reservoirs and valves.

Abstract: Infusion systems including infusion devices and consumables and related operating methods are provided. An exemplary method of operating an infusion device operable to deliver a fluid influencing a physiological condition to a body of a user involves a control module of the infusion device obtaining calibration data associated with a consumable coupled to the infusion device via an interface of the infusion device, determining a delivery command for delivering the fluid to the body of the user based at least in part on the calibration data, and operating a pumping mechanism to deliver the fluid from a reservoir of the consumable to the body of the user in accordance with the delivery command.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a user in accordance with an operating mode involves obtaining operational information pertaining to one or more prior instances of the operating mode, obtaining status information pertaining to the infusion device, and determining a diagnosis time based at least in part on the operational information. The diagnosis time is prior to a subsequent instance of the operating mode. At the diagnosis time, the method automatically determines the viability of the subsequent instance of the operating mode based at least in part on the status information and automatically generates a notification indicative of a recommended action for the user based at least in part on the viability.

Abstract: An ambulatory infusion device including a pump drive unit, a valve drive unit and a control unit. The pump drive unit includes a pump actuator and a pump driver coupled to a piston of a metering pump unit. The valve drive unit includes a valve actuator and a valve driver coupled to a valve unit for transmitting a valve switching force or torque. The control unit controls a repeated execution of: (a) placing the valve unit in a filling state; (b) displacing the piston in a retraction direction; (c) displacing the piston in an advancing direction by a backlash compensation distance; (d) switching the valve unit from the filling state into a draining state; and (e) further displacing the piston in the advancing direction in a number of incremental steps over an extended time period.

Abstract: A method of preparing a syringe in connection with a therapeutic treatment is disclosed. The method can include removing a plunger of the syringe from a barrel of the syringe, aligning the barrel in a horizontal orientation, filling a lumen of the barrel with a viscous material through an opening at a proximal end of the barrel, and inserting a plunger tip into the lumen to seal the lumen. The method can also include attaching an implantation device to a hub coupled to the barrel at a distal end of the barrel. The method can also include depressing the plunger until the cell suspension fills the implantation device and a droplet of the cell suspension is expelled from a distal tip of the implantation device.

Abstract: In selected embodiments, a handheld injection safety applicator includes an applicator housing with a handle and a retractable needle housed within the applicator. The applicator further includes a first sensor that detects the presence of a user's grip on the handle and a second sensor that detects the presence of an animal. The applicator also includes processing circuitry configured to receive a first signal from the first sensor indicating that the user is gripping the handle and receive a second signal from the second sensor indicating that an animal is detected. The applicator extends the needle out of the applicator into the animal once the first and second signal are received and delivers a dose of medication into the animal once the needle is fully extended into the animal.

Abstract: An exemplary embodiment of an injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger mechanism can include a floating trigger member having a retaining portion, a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

Abstract: An autoinjector for dispensing a liquid product includes a housing; a product container arranged in the housing, particularly, a syringe comprising a displaceable piston; a drive member; a first spring which acts on the drive member and the piston to dispense the product from the container; signal element releasably axially coupled with the drive member so that the signal element is transported in the dispensing direction as said drive member is displaced; and a second spring, which exerts a spring force on the signal element against the dispensing direction and is tensioned as the signal element is transported in the dispensing direction. When the signal element is released or detached from the axial coupling, the second spring causes the signal element to accelerate opposite the dispensing direction and strike against a signal stop and generate an acoustic and/or tactile signal.

Abstract: The present disclosure relates to a drug delivery device, comprising a shell adapted to contain one of a plurality of medicament containers prefilled with different deliverable volumes of a medicament. The shell is transparent at least in an area adapted to contain the medicament container, and a label adapted to be arranged on the shell. The label comprises a foil having a first surface and a second surface, which is adapted to be connected to the shell. At least one cutout or transparent area is arranged in the foil adapted to be placed on the shell such that a medicament container arrangeable or arranged within the shell is visible through the cutout or transparent area. The cutout or transparent area exhibits a size adapted to allow inspection of the deliverable volume of medicament within the medicament container when the label is applied to the shell.

Abstract: An injection device for dispensing a product, the injection device including a moveable element which is moved for a dispensing operation, a spring, a product container holder and a product container, wherein the spring pushes against the moveable element to move the moveable element to an initial position after the dispensing operation has ended and against the product container to seat the product container in the product container holder.

Abstract: The present disclosure relates to a state indicator designed for indicating at least three states (S1 to Sn) of a drug delivery device and formed as a single indicator for indicating a respective state (S1 to Sn) at least before injection, during injection and after injection.

Abstract: A sealing container is designed to enable a user to adjust the timing of discharging the contents. The sealing container includes: a bag-shaped member for accommodating the contents therein, a sealing film for sealing the bag-shaped member, an opening means so configured that at least a part of which is movable toward the sealing film and is capable of opening the sealing film, an operation unit for performing an operation of moving the opening means, and a discharge means configured to be capable of discharging the contents from the bag-shaped member at a timing different from a timing at which the opening means penetrates the sealing film by operating the operation unit. It is possible for the user to perform only the operation of opening the sealing film by operating the operation unit, so that the user is able to arbitrarily adjust the timing at which the content is discharged from the bag-shaped member of the sealing container.

Abstract: The present disclosure relates to a body arrangement for a drug delivery device, comprising at least one deployable body part arranged to be moved from a compact state into a deployed state, wherein the body part in the deployed state provides an enlarged grip area compared to the compact state.

Abstract: Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH-adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

Abstract: The invention relates to a method for reducing an amount of sub visible particles in a pharmaceutical composition contained in a medical injection device comprising a container (1) including a barrel (10) lubricated with a lubricant coating (2) in contact with the pharmaceutical composition, and a stopper (14) in sliding engagement within the barrel (10), the container comprising a region (130, 121, 123) extending distally from the distal end (100) of the barrel which is not accessible to the stopper. During formation of said lubricant coating (2) on the inner wall of the barrel, the method comprises limiting lubricant from being deposited into said region (130, 121, 123) extending distally from the distal end (100) of the barrel.

Abstract: A plunger rod for use with a syringe barrel includes a first flange adjacent a distal end of the plunger rod, a second flange adjacent a proximal end of the plunger rod opposite the distal end, and a securing flange between the first flange and the second flange. The securing flange is configured to prevent movement of the plunger rod in a proximal direction beyond a predetermined position when the plunger rod is disposed within the syringe barrel. A syringe assembly and a method of preparing a syringe assembly are also disclosed.

Abstract: Embodiments of the invention include a medicament device configured to provide stepwise instructions for using the device to a user in a particular sequence is provided. The device includes a device housing configured to receive a container, the housing including a control interface, the control interface including at least one responsive member reactive to a user input, an actuation mechanism configured to interact with the container, a signal output component associated with the device housing, and circuitry associated with the device housing configured to control a provision of the stepwise instructions to the user in the particular sequence. The container includes a first housing for containing a medicament, a second housing, and an injection member, wherein the first and second housings are movable relative to one another. The container further includes an injection member which is retractable within the second housing to prevent an unintentional contact with the injection member.

Abstract: A drug delivery device includes an inner body adapted to receive a pre-filled syringe with an injection needle, one or more flexible arms on the inner body extending in a distal direction, and one or more support members slidably arranged to operatively outwardly support the flexible arms. The flexible arms have respective inwardly directed protrusions adapted to engage a neck of the syringe. When the support member is in a distal position, it does not support the flexible arms. When the support member is in a proximal position, the support member supports the flexible arms and prevents them from being outwardly deflected.

Abstract: Disclosed is an apparatus for processing a hypodermic needle, comprising: a containment cylinder (17) for receiving the needle; a first electrode (16) for contacting the needle near a first end; a second electrode (20) for contacting the needle at its sharp end; a control system, operable to cause a current to flow in the needle between said first and second electrodes, whereby said current causes the needle to soften and wherein the second electrode is arranged to move within the containment cylinder and to provide a compressive force to the needle, wherein the containment cylinder is arranged to be heated by a heater in the form of a heater coil (not shown) surrounding the containment cylinder during the processing.

Abstract: A delivery tool connectable with a syringe can be used to deliver a viscoelastic solution. The tool includes a first segment, a second segment and an inner lumen defined by the first and second segments. A distal portion extends from the second segment in a curved manner.

Abstract: An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

Abstract: The present disclosure provides an apparatus for delivering an anesthetic agent to a target tissue in a nasal cavity of a patient. The apparatus includes an elongated shaft with a proximal end and a distal end. The apparatus also includes an absorbent plug coupled to the distal end of the elongated shaft. The absorbent plug is configured to occupy a first volume in a compressed state and a second volume in an uncompressed state. The absorbent plug is configured to store an anesthetic agent and deliver the anesthetic agent to the target tissue in the nasal cavity by contacting the target tissue. The apparatus also includes a sheath at least partially covering the absorbent plug. The sheath retains the absorbent plug in the compressed state when positioned at least partially over the absorbent plug, and removal of the sheath allows for the absorbent plug to expand to the uncompressed state.