Abstract: A PAP system for delivering breathable gas to a patient includes a flow generator to generate a supply of breathable gas to be delivered to the patient; a humidifier including a heating plate to vaporize water and deliver water vapor to humidify the supply of breathable gas; a heated tube configured to heat and deliver the humidified supply of breathable gas to the patient; a power supply configured to supply power to the heating plate and the heated tube; and a controller configured to control the power supply to prevent overheating of the heating plate and the heated tube.

Abstract: The invention comprises a ventilation apparatus and method for operating a ventilator of a ventilator apparatus, wherein in the method at least one duration ratio factor is set in a computing system of the ventilator apparatus; at least one minute volume, at least one functional dead space volume and at least one time constant are determined; a respiration frequency is computed, based on a previously defined lung model, depending on said determined parameters, where said computed respiration frequency is optimized on at least one minimum of a delivered parameter, which is induced to a patient using said ventilator; an inspiratory time and an expiratory time are determined based on said computed respiration frequency and said duration ratio factor; at least one tidal volume based on said previously computed respiration frequency and said determined minute volume is computed; and a delivered respiratory parameter of the ventilator is closed loop controlled.

Abstract: A portable anesthesia apparatus may include an anesthesia transportation cart, a hospital-grade anesthesia machine mounted on the anesthesia transportation cart, and a hospital-grade CO2 absorber mounted on the anesthesia transportation cart. The portable anesthesia apparatus may have an apparatus footprint area AFA of not greater than about 1.0 m2.

Abstract: A system for adjusting extrinsic positive end expiratory pressure during an expiratory phase of a ventilator is provided. The system includes a computer system that comprises one or more physical processors programmed with computer program instructions which, when executed cause the computer system to: determine a respiratory reactance from airway flow information of the patient and airway pressure information of the patient, the airway flow information and airway pressure information of the patient being obtained from one or more sensors, and adjust the extrinsic positive end expiratory pressure during the expiratory phase of the ventilator such that the determined respiratory reactance falls within a defined respiratory reactance range.

Abstract: An artificial airway device to facilitate lung ventilation of a patient. The device includes an airway tube including a lumen, a mask at one end of the airway tube. The mask includes a backplate and having a peripheral formation capable of forming a seal around the circumference of the laryngeal inlet. The peripheral formation surrounding a hollow interior space or lumen of the mask and the airway tube opening into the lumen of the mask. The device further includes fixation structure for fixation of the device to a patient when the device is in use. The fixation structure is movable with respect to the airway tube to allow for correct positioning of the device with respect to the anatomy of the patient.

Abstract: A tracheal tube including: a catheter, a suction tube, a gas-charging tube, and an inflatable balloon. The catheter includes a first portion and a second portion. The first portion includes a first hole and a second hole, and the second portion includes a third hole and a fourth hole. The gas-charging tube includes a first end and a second end. The suction tube includes a first end and a second end. The inflatable balloon is disposed on the second portion of the catheter. The inflatable balloon includes a flange, and the inflatable balloon is fixed on the second portion via the flange. The first end of the gas-charging tube is disposed outside the catheter, and the second end of the gas-charging tube enters the catheter via the first hole and extends to connect to the third hole. The first end of the suction tube is disposed outside the catheter.

Abstract: A technology is described for monitoring a tracheal intubation procedure. An example method may include receiving procedure data associated with a tracheal intubation procedure from at least one device used to monitor the tracheal intubation procedure. The procedure data received from the at least one device may be analyzed to determine a status of the tracheal intubation procedure and detect irregularities in performing the tracheal intubation procedure. Thereafter, instructions for performing the tracheal intubation procedure which correspond to the status of the tracheal intubation procedure may be provided to an output device, wherein the instructions include information associated with any irregularities detected during performance of the tracheal intubation procedure.

Abstract: A clip for use with an airway tube assembly is provided, the clip including a body, a proximal element, and a distal element. The body extends from a proximal end to a distal end. The proximal element projects outwardly from the proximal end of the body. The proximal element is adapted to extend over a proximal end of the airway tube assembly and to restrict proximal movement of the airway tube assembly relative to the clip. The distal element projects outwardly from the distal end of the body. The distal element is adapted to be coupled to the airway tube assembly and to restrict distal movement of the airway clip relative to the clip.

Abstract: A respirator mask liner is provided for positioning between a respirator mask and the face of a wearer. The mask liner includes a flexible sheet material having an outer perimeter edge portion and a hole that is spaced inwardly from the outer perimeter edge portion. At least one tab projects outwardly from portions of the perimeter edge portion, and may be unitarily formed with the sheet material. The mask liner is configured so that when it is to be placed between the face of the wearer and the respirator mask, the tab or tabs project outwardly beyond the gasket portion of the respirator mask, so that the tabs may be used for adjusting the liner or securing the liner to the mask. Optionally, the mask liner has a surface texture with a ribbed and undulating pattern of raised portions, and/or incorporates an anti-microbial substance.

Abstract: A neck strap, a crown strap assembly and a headgear for a breathing mask. The neck strap for a headgear includes a one-piece main body adapted to engage a patient's neck, first and second lower connection portions adapted to connect to first and second lower mask connection straps, and first and second upper connection portions adapted to connect to respective first and second lateral crown straps.

Abstract: A tracheal tube (e.g., an endotracheal tube) includes an inserting cannula (that may be able to swivel), and wherein the inserting cannula is connected to an elbow adaptor through a Bayonet Neill-Concelman (BNC) connection. The BNC connection may provide more secure connection of the corresponding components and may be able to withstand greater amounts of force exerted on them without becoming detached from each other. The elbow adapter may further be coupled to a pressure release valve that will alleviate pressure buildup within the tracheal tube.

Abstract: A humidifier heater base assembly has a heater plate with a thermally conductive portion and a perimeter portion around a perimeter of the heater plate. A resilient member has an inner part attached to the perimeter portion and an outer part adapted to provide a resilient perimeter flange around at least part and preferably the whole of the perimeter portion. The resilient member fixes the heater base to the humidifier by the resilient perimeter flange such that the heater plate and the inner part can move relative to the humidifier in a direction substantially transverse to the general plane of the heater plate. At least a portion of the resilient perimeter flange remains stationary relative to the humidifier.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways includes a frame member, a cushion assembly provided to the frame member, and an anterior wall member repeatedly engageable with and disengageable from the cushion assembly. The frame member includes connectors operatively attachable to a positioning and stabilizing structure. The cushion assembly includes a seal-forming structure and a void defined by an anterior surface of the cushion assembly. The anterior wall member has a predetermined surface area to seal the void of the cushion assembly and form a gas chamber when the anterior wall member and the cushion assembly are engaged. The void of the cushion assembly is sized such that the patient's nose and/or mouth is substantially exposed when the anterior wall member is disengaged from the cushion assembly thereby improving breathing comfort of the patient.

Abstract: In a method for performing an inhalation a reservoir is filed with a medication fluid or a medication container is connected to a designated connecting piece, a nebulizer unit is connected to a control unit and a mouthpiece, the nebulizer unit is activated, the medication fluid is atomized into a fine particulate aerosol which is emitted into an aerosol chamber formed by the nebulizer unit and the mouthpiece, and an inhalation is performed by a user. A pressure within the aerosol chamber and/or a flow rate through the aerosol chamber is measured using the control unit. The nebulizer is activated with each breath on occurrence of at least one activation criterion detected using the control unit. The nebulizer unit is deactivated with fulfillment of at least one stop criterion.

Abstract: This disclosure describes a passive inline oil delivery system for delivering a controlled and variable amount of an oil, such as an aromatic or essential oil, to a user via a positive airway pressure system. A positive airway pressure system may include a tube that delivers pressurized air to a user during, for example, sleep. Examples of such positive airway pressure systems include continuous positive airway pressure (CPAP) systems, automatic positive airway pressure (APAP) systems, and bilevel positive airway pressure (BiPAP) systems. The inline passive oil delivery system described herein delivers a controlled and/or adjustable amount of oil into the air delivered by the positive airway pressure system to the user.

Abstract: Disclosed is a local cooling anesthesia device for spraying a coolant on a treatment site. The local cooling anesthesia device includes a housing which forms an outward form and from which the coolant is sprayed and a spraying unit installed in the housing to spray the coolant. The device also includes a cooling temperature regulator connected to the spraying unit to apply thermal energy to the sprayed coolant for temperature regulation and a control unit connected to the cooling temperature regulator to control the cooling temperature regulator. The cooling anesthesia device has functions of measuring and regulating the temperature of the coolant, and thus can apply the coolant to the treatment site within a safe temperature range according to the purpose of treatment, thereby enabling a desired treatment purpose such as local anesthesia to be safely and rapidly accomplished without side effects such as cytoclasis.

Abstract: A light health care system including a physiological sensing device, a processor, and a light source device is provided. The physiological sensing device is adapted to acquire physiological data of a user. The processor is coupled to the physiological sensing device, and the processor acquires at least one light parameter corresponding to the physiological data according to the physiological data. The light source device is coupled to the processor, and the light source device outputs a light beam according to the at least one light parameter, wherein a green light beam or a blue light beam in the light beam accounts for more than 40% of the light beam. A light health care method is also provided.

Abstract: Polymer catheters and guidewires for use in intravascular surgery, and more particularly polymer catheters and guidewires micro-machined with a micro-cutting machine to provide sufficient flexibility to travel through a patient's vasculature while retaining sufficient torquability to transmit torque from a proximal end to the distal end of the catheter or guidewire, and methods of producing the same.

Abstract: The present disclosure provides a catheter including a reinforcing wire layer wound on a main lumen; a first marker having a ring shape, and a second marker having a ring shape and positioned closer to a proximal side than the first marker, each the first and second markers being provided around the reinforcing wire layer and containing a radiopaque metallic material; and an outer layer including the reinforcing wire layer, the first marker, and the second marker. The reinforcing wire layer is formed in a layer beneath the first marker and the second marker, and at least a part of a region between the first marker and the second marker is a non-forming region in which the reinforcing wire layer is not formed.

Abstract: A flexible needle system may comprise a tubular body, a needle assembly and a connector body. The tubular body may include a leading end and a trailing end. The tubular body may be configured to flex between an initial configuration and a flexed configuration. The needle assembly may include a needle body with a needle extending therefrom. The leading end of the tubular body may be configured to selectively receive the needle body, and the trailing end of the tubular body may be configured to selectively receive the connector body. A method may include providing a flexible needle system.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A medical tube securing jig includes: a skin securing member having a flange portion and a protruding body; and a medical tube holding mechanism part to hold the medical tube. A recessed portion is formed on the protruding body and has female threads. The medical tube holding mechanism part includes: a sealing member elastically deformed by a pressing force applied to the sealing member when the sealing member engages with the recessed portion by fitting engagement thus being brought into close contact with a side wall surface of the recessed portion, a bottom surface of the recessed portion and the medical tube; and a sealing member pressing body having male threads and configured to apply the pressing force to the sealing member in fastening by making the male and female threads engage, and a slit portion is formed in the sealing member.

Abstract: The endovenous treatment device has a delivery system (1; 2) for delivering of at least one treatment dose, which delivery system (1; 2) includes a wire element (1) for delivery of a treatment dose, which has a distal end part (10) able to be inserted, over at least part of its length, longitudinally into a vein, and which allows at least one treatment dose to be delivered into a vein in the region of the end of said distal end part (10). It additionally includes a drive system (4) by which the wire element (1) for dose delivery can be driven in at least a first given drive direction (R), and a guide (3) which is flexible along all or part of its length. The device includes a holding system (5) by which the distal end part (30) of the guide (3) can be temporarily held with respect to the body of a patient, near the insertion zone (7) of the wire element (1).

Abstract: The invention relates to an infusion catheter device. This catheter device 10 has an elongate, substantially tubular shape defining a longitudinal axis, a distal end (D) and a proximal end (P), configured to be introduced into a conduit (50) having an inner wall (54) and an outer wall (56) and comprising at least one partial or total obstruction (60) or occlusion to be treated, said device comprising, at its distal end (D), one or more infusion orifices (16, 18, 20, 22) for an infusion liquid (LI), and, upstream from the one or more infusion orifices, at the proximal side (P) of the infusion catheter (10), at least one obturating element (70) for temporary obturating, configured to treat said obstruction (60) or occlusion and to perform the infusion of the infusion liquid (LI) downstream from the obturating element (70) and in the obturating position. This device is suitable in particular for cardiac surgery and interventional cardiology.

Abstract: Surgical drains and methods for using the same for draining a body cavity are provided. Aspects of the surgical drains of the invention include an elongated structure having a proximal end and a distal end and a lumen configured to drain a substance from the body cavity. The distal end is configured to be placed in a body cavity and change in diameter when present in the body cavity from a first diameter to a second diameter that is smaller than the first diameter, where the change in diameter is mediated by a diameter-varying element. Aspects of the invention further include sheaths configured to be disposed around surgical drains, such as surgical drains of the invention, and methods of using the surgical drains and sheaths. The devices and methods of the invention find use in a variety of applications.

Abstract: Methods and tools are disclosed for treating chronic fatigue syndrome and fibromyalgia in a patient by diverting cerebrospinal fluid from the cerebral ventricles or the spinal subarachnoid space of the patient.

Abstract: The invention provides methods of determining a therapeutically effective dose of an agent that targets a metabolic pathway based on measured levels of a metabolite in the pathway. The methods, which may include providing the agent in a therapeutically effective dose, are useful for treating disorders, such as cancer, in a subject. The invention also provides methods for assessing the impact of a therapeutic agent on a tumor in a subject by monitoring, in real time, metabolism of a molecule in the tumor, oxygenation of the tumor, or both. The invention further provides devices that determine a therapeutically effective dose of an agent that targets a metabolic pathway based on measured levels of a metabolite in the pathway and notify a subject to administer the dose.

Abstract: The present invention provides an apparatus for producing medical foam for wound care or hair stimulation. The apparatus includes a foam generation unit having a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

Abstract: Medicinal pellet insertion devices and kits including sterile loading sheaths and scalpels for making predetermined incisions are provided. The devices and kits can be used in the treatment of patients with controlled, sustained release medicinal pellets implanted by subcutaneous insertion.

Abstract: A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.

Abstract: Various embodiments include a locking catheter splice assembly that may include a multi-stage barb fitting, a first locking member, and a second locking member. The multi-stage barb fitting may have a first end including a first set of barbs and a second end including a second set of barbs. The first end may be configured to be inserted into the first catheter and the second end may be configured to be inserted into the second catheter. The first locking member may be slipped over the first catheter so as to surround the portion of the first end of the multi-stage barb inserted into the first catheter. The second locking member may be slipped over the second catheter so as to surround the portion of the second end of the multi-stage barb inserted into the second catheter. The first and second locking members may interlock with one another when pressed together.

Abstract: A Y-connector for medical lines, includes a tubular body provided with a first inlet coaxial to the tubular body and containing a valve device formed by an elastic element, and a second inlet arranged obliquely to the tubular body and communicating therewith between the first inlet and the outlet. The tubular body is formed with an inner septum for deviating a flow coming from the second inlet towards the hollow elastic element prior to directing the flow to the outlet.

Abstract: One aspect is a manufacturing method including providing at least a first electrically conductive wire with an electrical insulation and a second electrically conductive wire with an electrical insulation, providing a first and a second ring electrode surrounding the wires, electrically connecting the first ring electrode with the first wire and the second ring electrode with the second wire, bundling the ring electrodes and the wires by means of a first sheath surrounding the ring electrodes and the wires to obtain a first ring electrode component, providing a second ring electrode component, bundling the ring electrode components by means of a second sheath surrounding the ring electrode components, and partially removing the first and the second sheaths from the ring electrodes to expose ring electrode portions.

Abstract: A distal electrode of an electrode assembly, for example, employed by an implantable medical electrical lead device, extends distally from a distal terminal end of a sleeve of the assembly; and the sleeve, which defines a longitudinal axis of the assembly, includes a plurality of channels that provide fluid communication between a steroid eluting component, which is seated in an external groove of the sleeve, and an area distal to the distal terminal end of the sleeve. Floors of some or all of the sleeve channels may angle toward the longitudinal axis of the assembly, being closer to the axis at the distal terminal end of the sleeve. The assembly may further include a proximal electrode secured to a proximal end of the sleeve, wherein the proximal electrode may be mounted around an outer surface of the sleeve or coupled to the sleeve by means of a coupling component.

Abstract: A system and method for extracting a cardiac signal from a spinal signal include measuring a spinal signal at one or more electrodes that are connected to a neurostimulator and implanted within a patient's spinal canal and processing the spinal signal to extract the cardiac signal, which includes features that are representative of the patient's cardiac activity. Processing the spinal signal to extract the cardiac signal can include filtering the spinal signal using a first low-pass filter and a second moving average filter. Model reduction schemes such as independent component analysis can additionally or alternatively be employed to extract the cardiac signal. The extracted cardiac signal can include a number of features that correspond to an electrocardiogram and can be used to determine the patient's heart rate and/or to detect a cardiac anomaly.

Abstract: An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.

Abstract: In one aspect, a neuromodulation device is described herein. In some embodiments, a neuromodulation device comprises a chamber operable to receive a nerve, at least one electrode disposed in the chamber, and a channel defined by two walls. In some embodiments, the channel of the device is in fluid communication with an interior of the chamber and an external surface of the device. In another aspect, methods of neuromodulation are described herein. In some embodiments, methods described herein can use one or more neuromodulation devices described herein.

Abstract: A method and system for monitoring an electrotherapy treatment applied to a subject in need of such therapy. An ultrasound transducer array is positioned adjacent a tissue of the subject to which the electrotherapy treatment is to be applied. The electrotherapy treatment is administered to the tissue as a plurality of ultra-short electric pulses which generate an electric field in the vicinity of the tissue. The ultrasound transducer array detects acoustic signals which are induced by the electric field. The detected acoustic signals are then used to construct tomographic images which represent the electric field generated by the electrotherapy treatment during real-time.

Abstract: A device operates for secretion clearance and cough assistance by means of transdermal stimulation of muscle groups including the pectoralis majoris, the serratus anterior, and the abdominal muscles. The various muscle groups may be stimulated in different ways: not just different pulse trains but in addition, different stimulations to accomplish different phases of clearance or cough assistance. In a first phase a vibration action provided by the muscles (for example the pectoralis and serratus) is used to encourage the motion of mucus and other secretions within airways. In a second phase, the abdominal muscles for example might be stimulated differently so as to cause not a vibration but instead a coughing action, especially to detect and assist a natural cough. The invention further teaches a zone stimulator large enough to span and stimulate major muscles or groups of large muscles effectively.

Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

Abstract: A method of treating an ailment suffered by a patient using one or more electrodes adjacent spinal column tissue of the patient, comprises delivering electrical modulation energy from the one or more electrodes to the spinal column tissue in accordance with a continuous bi-phasic waveform having a positive phase and a negative phase, thereby modulating the spinal column tissue to treat the ailment. An implantable electrical modulation system, comprises one or more electrical terminals configured for being coupled to one or more modulation leads, output modulation circuitry capable of outputting electrical modulation energy to the electrical terminal(s) in accordance with a continuous bi-phasic waveform, and control circuitry configured for modifying a shape of the continuous bi-phasic waveform, thereby changing the characteristics of the electrical modulation energy outputted to the electrode(s).

Abstract: Methods and systems for electrical stimulation can include obtaining a biosignal of the patient; altering at least one stimulation parameter of an electrical stimulation system in response to the biosignal; and delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. In some embodiments, a power spectrum is determined from the biosignal. In some embodiments, the biosignal is at least two different biosignals measured at the same or different locations on the patient and a coherence, correlation, or association between the two biosignal is determined.

Abstract: One aspect of the present disclosure relates to a system for treating a medical condition in a patient. The system can include a neurostimulator that is in electrical communication with a remote transducer. The neurostimulator can be sized and dimensioned for injection or insertion into a pterygopalatine fossa (PPF) of a patient. The remote transducer, when activated and brought into close proximity to the patient's head, can cause the neurostimulator to deliver an electrical signal to a target neural structure located within the PPF to treat the medical condition.

Abstract: Cardiac electrical heterogeneity information may be used to determine whether one or more ventricle from atrium (VfA) paced settings for VfA pacing therapy are acceptable. Cardiac electrical heterogeneity information may be generated during VfA pacing, and then evaluated to determine whether the VfA paced settings are acceptable.

Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

Abstract: In some examples, an implantable medical device (IMD) including a hermetically sealed housing that is configured to enclose internal components. The internal components may include stimulation circuitry, processing circuitry configured to control the stimulation circuitry to deliver electrical stimulation using one or more leads received by the housing, telemetry circuitry, and a rechargeable power source. The IMD may also include a coil configured to at least one of receive energy to recharge the rechargeable power source or receive and/or transmit signals for wireless telemetry with another device, wherein the implantable medical device is configured to mount to a cranium of a patient, and wherein the coil is coiled about an axis that is approximately orthogonal to a major surface of the IMD.

Abstract: Techniques, systems, and devices are disclosed for delivering stimulation therapy to a patient. In one example, a medical device senses, via one or more electrodes, one or more oscillations of a bioelectrical signal of a brain of a patient. In response to sensing the one or more oscillations, the medical device generates a plurality of bursts of stimulation therapy pulses, the plurality of bursts comprising an inter-burst frequency selected based on a frequency of the one or more oscillations of the bioelectrical signal. Further, the medical device delivers the plurality of bursts of stimulation therapy pulses to the patient to modulate a state of the patient associated with the one or more oscillations of the bioelectrical signal.

Abstract: Stimulation of neural signalling of an apical splenic nerve can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders.

Abstract: An electrical stimulation system includes a control module that provides electrical stimulation signals to an electrical stimulation lead coupled to the control module for stimulation of patient tissue. The system also includes a sensor to be disposed on or within the body of the patient and to measure a biosignal; and a processor to communicate with the sensor to receive the biosignal and to generate an adjustment to one or more of the stimulation parameters based on the biosignal. The adjustment can be configured and arranged to steer the electrical stimulation signals to stimulate a region of the patient tissue that is different, at least in part, from a region of the patient tissue stimulated prior to the adjustment. Alternatively or additionally, the biosignal is indicative of a particular patient activity and the adjustment is a pre-determined adjustment selected for the particular patient activity.

Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.