Abstract: The present invention provides a system and a method for measuring ocular motility of a patient.

Abstract: An apparatus for non-contact examination of an eye comprises for illuminating and imaging the eye: an apparatus objective of a positive optical power and a positive spherical aberration which illuminates and images an angle wider than a cross section of the zone I of the retinal vasculature, the apparatus objective being common to the imaging and the illumination the optical paths of which are deviated from each other in the examination apparatus; and a secondary lens unit, which is located behind the apparatus objective in the optical path in a direction of the imaging, modifies at least one of the following optical features: lateral color aberration, astigmatism, field curvature and coma caused by the apparatus objective, and focuses the imaging radiation modified by the secondary lens unit on an image sensor for forming an image of a retina of the eye.

Abstract: Systems and methods for Broad Line Fundus Imaging (BLFI), an imaging approach that is a hybrid between confocal and widefield imaging systems, are presented. These systems and methods are focused on improving the quality and signal of broad line fundus images or imaging methods to create high contrast and high resolution fundus images. Embodiments related to improved pupil splitting, artifact removal, reflex minimization, adaptable field of view, instrument alignment and illumination details are considered.

Abstract: A computer-implemented method detects the position of a corneal vertex of an eye from a frontal image of a head and a lateral image of the head. The front and lateral images are calibrated to one another, and the position of the corneal vertex in space is determined from the frontal image and the lateral image with a geometric position determination.

Abstract: An electromagnetic mems-transformer includes arrays of nanostructured first toroid winding by a self-assembled organic conductive membrane on an electrode, and a second toroid winding with “donut” shape cyclodextrins (CDs) comprising of different electronegativity functional groups was inserted in the first toroid; a hydrophobic laminate agent forms a linen lining the first cavity of the toroid in perpendicular to the first and second toroid with air gaps for adjusting, upon applying a DC potential crosses two electrodes in a fluid medium for initiation of the device, a changing current flows until reached the s-s state in a nano Ampere level. When held the nano Ampere current in constant for spontaneous discharge voltage pulses, the current induced an electromagnetic flux change with orders of magnitude higher output voltage produced compared with the initiation potential. Embedded on-off switches promoted hysteresis i-V curves for memory function.

Abstract: Embodiments are related to systems and methods for data determining information about a subject, and more particularly to systems and methods for utilizing and distributing information related to measurements of a human subject.

Abstract: A device (1) for processing and transmitting measured signals which correspond to implant parameters or biological parameters for monitoring and/or controlling medical implants, diagnostic devices or biological processes including: a biocompatible sterilizable covering (9); an electronic signal processing device (2) electrically connectable to at least one sensor (5) for processing measured signals received from the at least one sensor; a data memory (16) electrically connected to said signal processing device for storing data received from said signal processing device; and a data transmission device (4) electrically connected to said data memory for transmitting data received from said data memory to a remote data receiving device (6) which is connectable to an external data processing device (8). The signal processing device calculates statistically relevant data obtained from the measured signals, reducing the volume of stored data.

Abstract: A brain image reconstruction apparatus can reconstruct a brain image as a sharper image. A brain image reconstruction apparatus has a data acquisition unit that acquires brain activity data of a user; a brain image reconstructor that detects image information from the brain activity data and constructs a brain image; a linguistic information detector that detects linguistic information from the brain activity data; an image database that stores sample images corresponding to the linguistic information; and an image processor that superimposes the sample image with the brain image, and constructs a process image.

Abstract: A system and a related method extract physiological information from remotely detected electromagnetic radiation. The system includes an interface configured for receiving a data stream including image data representing an observed overall region of at least one subject of interest. A partitioning unit defines a plurality of sub regions in the overall region. A classifier classifies the plurality of sub regions into at least one indicative type of region and at least one auxiliary type of region. The at least one indicative type of region includes at least one indicative region of interest at least partially representing the subject of interest. The at least one auxiliary type of region includes at least one reference region. The system further comprises a data processor configured for processing at least one sub region classified as region of interest, thereby obtaining vital information.

Abstract: A method of luminance lifetime imaging includes receiving incident photons at an integrated photodetector from luminescent molecules. The incident photons being received through one or more optical components of a point-of-care device. The method also includes detecting arrival times of the incident photons using the integrated photodetector. A method of analyzing blood glucose includes detecting luminance lifetime characteristics of tissue using, at least in part, an integrated circuit that detects arrival times of incident photons from the tissue. The method also includes analyzing blood glucose based upon the luminance lifetime characteristics.

Abstract: In some embodiments, an oral care system includes a toothbrush and a smart device removably retained in the toothbrush and having a plurality of sensors for sensing conditions of the oral cavity. The sensors may include sensors that obtain information while the smart device is retained in the toothbrush and sensors that obtain information while the smart device is separated from the toothbrush.

Abstract: A smart phone or tablet includes a first part having at least one laser diode configured to be pulsed, and a second part having at least one other laser diode, the laser diodes configured to generate near-infrared light, wherein at least some of the laser diodes comprise a distributed Bragg reflector, with some laser diode light directed to tissue including skin. An array of laser diodes generates near-infrared light and includes one or more distributed Bragg reflectors. An assembly in front of the array to forms light spots on the tissue. A first receiver includes detectors that receive light reflected from the tissue. An infrared camera generates data from light reflected from the tissue. The smart phone or tablet generates a two-dimensional or three-dimensional image or mapping using the infrared camera data, and includes a wireless receiver, a wireless transmitter, a display, a voice input module, and a speaker.

Abstract: An apparatus for high resolution thermal imaging in medical applications has a single channel EMI shielded sensor, remote cable, and laptop controller with real time image processing software. The apparatus provides high resolution, real-time viewable infrared (IR) images with a variable focus distance adjustable from six inches to infinity. The present invention enables crisp, clear imagery of the thermal band for greater awareness of everything within the field of view. Various medical applications which would benefit from high resolution thermal imagery are presented.

Abstract: Video monitoring device comprising a computing unit, a camera, a communication interface, and a volatile organic compounds sensor configured to measure at least a concentration of organic compounds in a room of interest, said computing unit being configured to record the concentrations of organic compounds reported by the volatile organic compounds sensor, and configured to send images taken by the camera and volatile organic compounds concentrations to a remote entity, such as a smartphone over a wireless link.

Abstract: A hospitalization management system including a heart failure analyzer that receives diagnostic data including at least sensor data representative of one or more physiological signals sensed from a hospitalized patient using one or more sensors and assesses risk of rehospitalization for the patient using the diagnostic data. The outcome of the risk assessment is used during and following the patient's hospitalization for reducing the risk of rehospitalization.

Abstract: Monitoring heart activity using a wearable device, including receiving, from the wearable device, an electrocardiograph (ECG) signal and a motion signal associated with an individual upon contact with the wearable device; in response to receiving the ECG signal and the motion signal associated with the individual, determining, by a computing device, a position of the wearable device in contact with the individual; and determining, by the computing device, a heart activity monitoring mode for operating the wearable device, based on the position of the wearable device in contact with the individual.

Abstract: An acoustic sensor attached to a medical patient can non-invasively detect acoustic vibrations indicative of physiological parameters of the medical patient and produce an acoustic signal corresponding to the acoustic vibrations. The acoustic signal can be integrated one or more times with respect to time, and a physiological monitoring system can determine pulse or respiration parameters based on the integrated acoustic signal. The physiological monitoring system can, for instance, estimate a pulse rate according to pulses in the integrated acoustic signal and a respiration rate according to a modulation of the integrated acoustic signal, among other parameters. Further, the physiological monitoring system can compare the integrated acoustic signal or parameters determined based on the integrated acoustic signal with other signals or parameters to activate alarms.

Abstract: Provided is a technique in MRI to efficiently suppress downstream blood in a specific region in a blood vessel having a slow flow velocity, such as the portal vein. For this purpose, a plurality of Beam Sat pulses are applied so as to equally suppress signals of blood flowing into a desired imaging region from a desired blood vessel during the period from applying an IR pulse to starting main imaging. Downstream blood in a specific region in a blood vessel having a slow flow velocity, such as the portal vein, can be suppressed efficiently by determining application conditions of the plurality of Beam Sat pulses that achieve the above based on a flow velocity of blood in a desired blood vessel and T1 of the said blood.

Abstract: The present invention relates generally to an algorithm aimed at neurophysiology monitoring, and more particularly to an algorithm capable of quickly finding stimulation thresholds over multiple channels of a neurophysiology monitoring system.

Abstract: Devices and methods are described that provide improved diagnosis from the processing of physiological data. The methods include use of transforms prior to submitting the data to a multiple level neural network. In one embodiment for ECG analysis, a template is used to subtract data that is not pertinent to the diagnosis and then a Fourier transform is applied to the time series data. Examples are shown with applications to electrocardiogram data, but the methods taught are applicable to many types of physiological data.

Abstract: Provided herein are skin-mounted biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided, including electronic devices useful for establishing conformal contact with the skin of a subject. Devices disclosed herein can comprise a plurality of sensing and/or actuating devices provided as part of a skin-mounted flexible or stretchable electronic circuit.

Abstract: An electrode padset and a method of using the electrode padset are disclosed herein. The electrode padset is a single unit, consisting of multiple patient-contacting conductive pads arranged on a single piece of material. The padset is comprised of a plurality of conductive pads, at least one conductive pad adapted to emit an electrical signal and at least one other conductive pad adapted to receive an electrical signal, and an electrically conductive material coupling the conductive pads.

Abstract: An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.

Abstract: Cardiac catheterization is carried out by inserting a multi-electrode probe into a heart of a living subject, preparing a current position map of the electrodes to define respective locations of the electrodes, and recording electrograms from the electrodes. Activation times are annotated at the respective locations by analysis of the electrograms and generating an activation map. A region of the activation map is selected and earliest ones of the activation times in the selected region identified. The earliest activation times are graphically indicated.

Abstract: A method, apparatus and system for measuring electrical activity generated within a brain is disclosed. A headpiece having a first transistor is placed in contact with a head that contains the brain to bring the first transistor into electrical contact with the head. An electronic signal is generated at the first transistor in response to the electrical activity generated within the brain. The electronic signal is processed at the headpiece in order to measure the electrical activity.

Abstract: An EEG monitor with sensors placed to detect signals and analyze the signals to determine if a frequency below 12 Hz, and more particularly between 3 Hz and 8 Hz, called theta waves, are present. Theta waves are generated when the brain is entering a drowsy or sleep mode. The sensors detect brain wave signals and transmit the signals to a microprocessor which analyzes the signals and determines the brain waves being detected. The brain waves are continuously monitored and the data is continuously transmitted to a microprocessor. If brain waves are detected in the predetermined range of between 3 Hz and 8 Hz the microprocessor activates a stimulus, to wake up the person wearing the device. The stimulus may be visual, auditory or tactile, such as an actuator, a phone call or any other stimulus.

Abstract: A measuring device comprises a microwave transmitter, a microwave receiver, at least one antenna, a control device and a dielectric extension. The dielectric extension is disposed between the antenna and an object to be investigated. The control device controls the microwave transmitter and the microwave receiver. The microwave transmitter transmits a microwave signal by means of the antenna and the dielectric extension into the object to be investigated. The object to be investigated scatters the microwave signal. The microwave receiver receives the scattered microwave signal by means of the antenna and the dielectric extension. The length and the dielectric constant of the dielectric extension in this context are dimensioned in such a manner that the object to be investigated is disposed in the remote field of the antenna.

Abstract: A pre-shift set of fiducials each including a pre-shift fiducial impedance location and a pre-shift fiducial magnetic location can be determined. The pre-shift fiducial impedance locations and the pre-shift fiducial magnetic location are associated with a medical device. A post-shift set of fiducials each including a post-shift fiducial impedance location and a post-shift fiducial magnetic location can be determined. The post-shift fiducial impedance locations and the post-shift fiducial magnetic locations are associated with the medical device. A pre-shift transformation can be fit to the pre-shift set of fiducials and a post-shift transformation can be fit to the post-shift set of fiducials. A determination can be made whether the pre-shift transformation differs from the post-shift transformation.

Abstract: A catheter configured for use with a magnetic field-based localization system includes a distributed location sensor that includes a plurality of individual location sensing coils electrically connected in series. The distributed location sensor has an effective magnetic center based on the individual characteristics of each location sensing coil. The effective magnetic center can be located in a space occupied by another structure such as an irrigation fluid delivery tube. The plurality of individual location sensing coils are generally smaller, thereby easing placement, and collectively, when connected in series, output a relatively strong and noise-free signal.

Abstract: Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.

Abstract: A system and method for aiding in the diagnosis of a respiratory dysfunction is described. More particularly, a system and method for aiding in the diagnosis of one or more pulmonary embolisms is described. The system and method described herein include a plurality of sensors, a thermal control system, and a controller coupled to the plurality of sensors and the thermal control system for aiding in the diagnosis of a respiratory dysfunction.

Abstract: A nasal/oral cannula for collecting a flow of exhaled gases and its method of manufacture are disclosed. The cannula comprises an elongated tubular body having a first and a second end portion, a surface and an internal volume; a wall internally disposed within said tubular body, said wall defining a first subvolume of said internal volume in the lengthwise direction of the tubular body; and an inlet through said surface, for introducing exhaled gases into said first subvolume. The first end portion defines an exit port for exhaled gases from said subvolume, and said wall is arranged directly adjacent to said inlet.

Abstract: Device and method for classifying the activity and/or counting steps of a user. A method for classifying the activity of a user can comprise measuring accelerometer data for a plurality of axes; identifying a most active one of the plurality of axes based on the accelerometer data; and classifying the activity of the user based on a signal amplitude of the accelerometer data for the most active axis and one or more threshold values.

Abstract: Face detection device that detects a face from an image including a person. The device includes a processor and a memory including instructions that, when executed by the processor, cause the processor to perform operations including: receiving captured images by a camera, detecting one face region or more in the captured images, extracting vital information which includes an index indicating a living state of a face imaged in the face region, based on image data regarding the detected face region; and determining whether or not the face in the face region is in a living state, based on the vital information. The face region detector recognizes a face region corresponding to the face which is determined to be in the living state by the vitality determiner among the one face region or more, as a face region based on a living body.

Abstract: The application discloses a method, an apparatus and a system for measuring finger moisture. The method includes: obtaining a fingerprint image; obtain a signal intensity and an image background intensity according to the fingerprint image; and determining finger moisture according to the fingerprint signal intensity and the image background intensity. In the method, apparatus and system for measuring finger moisture provided by the present invention, the fingerprint image is obtained and the fingerprint signal intensity and the image background intensity are obtained based on the fingerprint image, and the finger moisture is determined by analyzing the fingerprint signal intensity and the image background intensity, thereby effectively overcoming the defects in prior art in comparing and analyzing of images, including being prone to be disturbed by undulation of the image background, noise, etc., and low accuracy, thus ensuring the accuracy and reliability of the measurement of the finger moisture.

Abstract: An audiologic test apparatus includes: a pump device configured to apply a first pressure to the ear canal; and a processing module for communicatively coupling to the pump device and to a signal generator, wherein the processing module is configured to obtain first acoustic parameter values indicative of an acoustic parameter at the first pressure based on a first broadband signal generated using the signal generator; wherein the pump device is configured to change the first pressure to a changed pressure, and wherein the pump device is also configured to apply a second pressure to the ear canal; and wherein the processing module is also configured to obtain second acoustic parameter values indicative of the acoustic parameter at the second pressure based on a second broadband signal generated using the signal generator, and determine a middle ear resonance frequency based on the first and second acoustic parameter values.

Abstract: A noninvasive mid-infrared in vivo glucose sensor for use in connection with the skin of a test subject is disclosed. The sensor includes a mid-infrared light source configured to deliver a light beam to the skin of the test subject, a collector element configured to collect backscattered light from the skin and direct it to the detector, and a detector element configured to measure the collected backscattered light from the skin. The mid-infrared light source may be a quantum cascade laser. The sensor may include optical fibers configured to deliver the light beam to the skin of the test subject. The collector element may be an integrating sphere or a bundle of two or more optical fibers. The sensor may also include a probe containing or connecting to optical fibers coupled to the mid-infrared light source and configured to be placed on the skin to take glucose level readings.

Abstract: A method of assisting daily living for an individual, comprising the steps of measuring a presence and/or concentration of one or more biomarkers in a sample from the individual; predicting a behavior or emotional state of the individual based on the measured presence and/or concentration of the one or more biomarkers by applying a correlation between human biological phenotype and human behavioral and/or emotional phenotype; and altering the living environment of the individual or providing information, advice or guidance to the individual based on the predicted behavior or emotional state of the individual, where the correlation between human biological phenotype and human behavioral and/or emotional phenotype comprises a correlation between the one or more biomarkers and a behavior or emotional state. A system for assisting daily living for an individual is also provided.

Abstract: A space-saving structural component for a device, the device configured to non-invasively determine a tissue bioparameter of a mammalian subject, the component comprising a wall surface including a grooved recess and at least one shoulder; and a substantially flat cover, the cover configured to cover the wall surface by moving from an open position far enough away from the wall surface to allow insertion of an appendage of the subject into a chamber defined by the grooved recess and the cover, to a closed position, the cover comprising a flexible material that, in the closed position, elastically deforms away from the wall surface when the appendage is present in the grooved recess and restores to a substantially flat state when the appendage is absent from the grooved recess, wherein in the closed position, when the appendage is absent from the recess, the cover is adjacent the at least one shoulder.

Abstract: Provided herein are methods for extracting blood from a subject's digit, such as a finger. Methods provided herein may release relatively large quantities of blood from a pierced finger. Pressure can be applied at selected locations on the subject's digit to increase blood flow released from the subject.

Abstract: An arrangement includes a housing, a plurality of sampling and analysis sites contained within the housing, each of the sampling and analysis sites having a skin-penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator operatively associated with the skin-penetration member, and an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member. Integrated devices including such arrangements are also described.

Abstract: A collection fitting, system, and method for sampling fluid from a tissue site is described. The collection fitting includes a switch fitting having a first passage and a second passage. The collection fitting also includes a bypass switch coupled to the switch fitting. The bypass switch is operable to fluidly couple the first passage and the second passage through the bypass switch. The bypass switch is also operable to fluidly couple the first passage and the second passage through a specimen container.

Abstract: A configurable system is used to evaluate stimulus sensitivity of a subject. An action channel provides a stimulus to the subject and a reaction channel receives a response from the subject. A signal pathway is connected to the action channel and to the reaction channel. A controller establishes loops within the signal pathway. Loop types include a transduction loop including the action channel and forming a path terminating in the signal pathway, and a channel loop including the action channel and terminating at a reference unit. Other possible loop types include an interface loop including the action channel, the reaction channel and the reference unit having an initial parameter value, and an adaptive loop including the action channel, the reaction channel and the reference unit whose parameter value is adapted based on the response from the subject. A method using the system is also described.

Abstract: A muscle power detection device and a muscle power detection method for detecting and classifying a muscle power status of a subject are provided. The muscle power detection device includes an inertia measurement unit, a pressure detection unit and a processing unit. The inertia measurement unit is configured to be arranged at a part of the subject and to obtain inertial data corresponding to the part of the subject according to movement status of the part of the subject. The pressure detection unit is configured to detection external force applied on the part of the subject to obtain pressure data. The processing unit is configured to perform an operation on the inertial data and the pressure data for obtaining evaluation values, and to obtain muscle power information corresponding to the part of the subject according to the evaluation values.

Abstract: A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.

Abstract: A device for treating bone in a living body includes (a) comprises an implant configured for attachment to a bone; (b) a first sensor measuring a strain on a first portion of the implant, the first portion of the implant being configured to be mechanically coupled to a weakened portion of a bone when the implant is coupled to the bone in a target position in combination; and (c) a second sensor measuring strain in a non-weakened portion of the bone.

Abstract: The method of detecting bone fractures using backscattered light makes use of backscattered near infrared (NIR) light to determine if a body part of a patient is healthy, has a bone fracture, or has an edema. An incident beam of near infrared light is generated by a light source, and has both an incident amplitude and an incident phase. The incident beam of NIR light is directed toward the patient's body part, and a backscattered beam of NIR light is received from the body part. The backscattered beam of NIR light has a backscattered amplitude and a backscattered phase. The determination of whether the body part is healthy, has a bone fracture or has an edema is made based on the level of absorption of the incident beam of NIR light and/or based on the amount of scattering, based on the phase difference, of the incident beam of NIR light.

Abstract: A method to determine a position and a state of a personal activity monitor worn by a user, such personal activity monitor comprising a motion sensor formed as an at least 3-axis accelerometer and a processor unit, the method comprising the steps of determining a number of changes of predominant axis per time period, and comparing it with exceeds a first predetermined threshold in order to infer a wrist worn condition, the method comprising the steps of determining a current level of activity and a temperature criterion to infer that the personal activity monitor is actually worn by the user and that the user has entered a sleep phase, or to infer that the user has emerged from sleep.

Abstract: Disclosed herein, among other things, are methods and apparatus related to identification of apnea type. One aspect of the present subject matter provides a method for real-time apnea discrimination. The method includes sensing an impedance-based tidal volume signal to monitor a respiratory cycle of a patient, and detecting a reduction in tidal swing using the sensed impendence to detect an apnea event. When the apnea event is detected, a shape of the sensed signal is compared to a stored signal shape to determine whether the apnea event is primarily an obstructive sleep apnea (OSA) event or primarily a central sleep apnea (CSA) event, in various embodiments.

Abstract: A method and apparatus for monitoring and/or managing adherence to a medication regimen that involves use of a sensor. Dispensing medicine from a container commonly involves pressure being applied to the container, which results in expansion of the container. In some embodiments, pressure is applied by a user through an aperture of the apparatus. In some embodiments, a processor monitors pressure sensor data from a pressure sensor that is physically coupled to the container and arranged such that activation of the pressure sensor indicates the container has expanded in response to the user applying pressure. A processor analyzes the pressure sensor data to determine whether medicine has been dispensed from the container. A computer system can compare the dispensed medication to a planned medication regimen to determine a state of compliance with the medication regimen.