Patents Issued in October 15, 2019
  • Patent number: 10441674
    Abstract: The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 15, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Hans Christian Hedrich, Joris Hoefinghoff
  • Patent number: 10441675
    Abstract: A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photoactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: October 15, 2019
    Assignee: Cook Medical Technologies LLC
    Inventors: Alan George Brownlee, Christopher Malcolm Elvin
  • Patent number: 10441676
    Abstract: A bioanalogic implantable ophthalmic lens (“BIOL”) capable of replacing the natural crystalline lens (NCL) in its various essential functions after the NCL having been removed and BIOL implanted into the posterior eye chamber and placed into the capsular bag vacated from the NCL. At least the posterior surface of the lens has a convex shape and is made from a transparent flexible hydrogel material. At least the anterior and posterior optical surfaces are defined by rotation of one or more conic sections along the main optical axis and the surfaces defined by the rotation will include a plane perpendicular to the axis and conical surface symmetrical by the axis. A hydrogel implantable ophthalmic lens whose optical parameters can be optimized and/or customized by a controlled absorption of electromagnetic radiation resulting in a change of the refractive index of the irradiated hydrogel.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 15, 2019
    Assignee: Medicem Institute s.r.o.
    Inventors: Vladimir Stoy, Václav Petrák, Miroslav Dudi{hacek over (c)}
  • Patent number: 10441677
    Abstract: Injectable compositions and methods for treating an injured tendon in an animal or human are disclosed herein. The injectable compositions include an effective amount of a carbohydrate to increase osteotendinous hydration and lubrication.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: October 15, 2019
    Assignee: Anika Therapeutics, Inc.
    Inventors: Colin D. White, Edward S. Ahn, Sekoni Daouda Noel
  • Patent number: 10441678
    Abstract: Mono- and multi-layered implants include at least one porous layer made from a freeze dried aqueous solution containing chitosan, the solution having a pH of less than about 5.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: October 15, 2019
    Assignee: Sofradim Production
    Inventors: Sébastien Ladet, Julien Claret
  • Patent number: 10441679
    Abstract: In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: October 15, 2019
    Assignee: WARSAW ORTHOPEDIC, INC.
    Inventors: Jeffrey M. Gross, Steve Peckham, Jeffrey L. Scifert, Jeffrey Badura, Nelson Scarborough, Scott Vickers
  • Patent number: 10441680
    Abstract: Described herein are placental tissue grafts produced by chemical dehydration followed by freeze-drying the placental tissue to produce the tissue graft. The tissue grafts retain their biological properties preferably at the same level as the placental tissues before they are processed. The placental tissue grafts have numerous medical applications. Methods for making the tissue graft compositions are also described herein.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: October 15, 2019
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, Steven Ray
  • Patent number: 10441681
    Abstract: The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue using nerve grafts and preparation of nerve grafts. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue and nerve graft. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also includes storage solutions for nerve tissue.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: October 15, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventor: David F. Muir
  • Patent number: 10441683
    Abstract: Disclosed is directed to a method for restoring bone in an animal comprising: accessing a site to be restored; loading a syringe body with a flowable bone graft material; mating the syringe body with a delivery tube; positioning the delivery tube at the site to be restored; using a syringe piston to advance the said material into the delivery tube; using the syringe piston or a plunger that mates with the delivery tube after removal of the syringe body to deliver the bone graft to the site at a force of less than 50 lbs. extrusion force; wherein said material is at least 75% porous with a mineral to polymer ratio of 80:20.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: October 15, 2019
    Assignee: Orthovita, Inc.
    Inventors: Charanpreet S. Bagga, Theodore D. Clineff, Erik M. Erbe, Michael W. Paris, Gina M. Nagvajara, Antony Koblish
  • Patent number: 10441684
    Abstract: Implementations described herein provide for junctionless monolithic composite implants and methods for manufacturing the same. The implant includes a monolithic composite body having a first region comprising a first metal alloy, a second region comprising a second metal alloy, and a transition region disposed between the first region and the second region formed from a bonded mixture of the first alloy and the second alloy. In one example, the transition region is a sintered mixture of the first alloy and the second alloy. In another example, the transition region is disposed at a region of minimum stress within the monolithic composite body under physiological loading conditions of the implant.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: October 15, 2019
    Assignee: Zimmer, Inc.
    Inventor: Cristina Piecuch
  • Patent number: 10441685
    Abstract: A system and methods for producing a structure including a plurality of fibers is provided. The system includes a polymer collector having a predefined pattern, wherein the collector is charged at a first polarity, and a spinneret configured to dispense a polymer, wherein the spinneret is charged at a second polarity substantially opposite the first polarity such that polymer dispensed from the spinneret forms a plurality of fibers on the predefined pattern of the fiber collector.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: October 15, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventor: Matthew R. MacEwan
  • Patent number: 10441686
    Abstract: The present invention relates to a stent having a functional material coated on a cell space (safe coating space) thereof. The stent of the present invention, as a stent having a space for mounting and coating drugs and other materials for expanding the functions of the stent, is highly feasible as an actual product in consideration of the structure, transfer device, and manufacturing process of the stent as a whole, and secures a coating space (safe coating space) of a functional material in a cell of the stent through quantitative and qualitative modelling. Since an additional increase in volume does not occur even when the stent is press-mounted in a transfer device as a result of mounting a radio marker or a drug in the coating space, the stent of the present invention has excellent radio opacity without obstructing the loading and deployment of the stent, and may stably mount a great amount of a functional drug.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: October 15, 2019
    Assignees: UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER, NEXTBIOMEDICAL CO., LTD.
    Inventors: Don Haeng Lee, Jong Chae Park, Dong Gon Kim, Choong Ryeol Choi
  • Patent number: 10441687
    Abstract: A product comprising a stent for a human blood vessel which comprises (i) a scaffold which is impregnated with, adsorbed with, or coated with an inhibitor of a Wnt/p-catenin pathway, or (ii) a scaffold coated with a polymer, which polymer is impregnated with, adsorbed with, or coated with an inhibitor of a Wnt/p-catenin pathway, and methods of use to reduce the risk of restenosis.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 15, 2019
    Assignee: Albert Einstein College of Medicine
    Inventors: Nicholas Ernst Smit Sibinga, Dario Fernando Riascos-Bernal
  • Patent number: 10441688
    Abstract: A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: October 15, 2019
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Joseph T. Delaney, Jr., David R. Wulfman, Adeniyi O. Aremu, Adegbola O. Adenusi
  • Patent number: 10441689
    Abstract: A method for manufacturing a bioactive implant including the steps of (a) forming a mixture of an bioactive agent and a setting agent capable of transitioning from a flowable state to a rigid state; (b) converting the mixture into a flowable state; and (c) transitioning the mixture into a solid state in a shape of the implant.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: October 15, 2019
    Assignee: Louisiana Tech Research Corporation
    Inventors: Jeffery Adam Weisman, Connor Nicholson, David Mills
  • Patent number: 10441690
    Abstract: Systems and methods for wound drain management. Certain embodiments include an infection indicator and/or a coupling device configured to such that a wound drainage container can rotate in relation to a mounting device.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: October 15, 2019
    Assignee: Western Connecticut Health Network, Inc.
    Inventor: Theresa Brandon
  • Patent number: 10441691
    Abstract: A device for removing fluid from a body, the device comprising an array of microneedles and a housing; the array of microneedles being disposed within the housing and the housing defining a chamber. The microneedles are moveable between a disengaged position and an engaged position where, in use in the engaged position, the microneedles penetrate the surface of a body. The chamber is adapted to surround the surface of the body through which the microneedles penetrate when in the engaged position. The chamber is configured for connection to a vacuum device such that negative pressure can be applied to the chamber.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: October 15, 2019
    Assignee: Renephra Limited
    Inventors: Simon Todd, Ian Middleton
  • Patent number: 10441693
    Abstract: A blood pump including a housing defining a proximal end, a distal end, and a first axis extending from the proximal end to the distal end. A ferromagnetic rotor is disposed within the housing and configured pump blood in a direction along the first axis. A stator is disposed within housing and around the ferromagnetic rotor, the stator is configured to apply a magnetic force causing rotation of the ferromagnetic rotor, the stator being eccentric to the rotor.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: October 15, 2019
    Assignee: HeartWare, Inc.
    Inventors: Jeffrey A. Larose, Carlos Reyes, Charles R. Shambaugh
  • Patent number: 10441694
    Abstract: A medical balloon for a balloon pump is disclosed. The medical balloon has a first end and a second end and a port at one of the ends for engaging a catheter for receiving an inflation fluid into the balloon. The balloon has one or more exterior walls defining, when the balloon is inflated at substantially a standard operating pressure, a taper along at least a part of the length of the balloon. The taper has two or more consecutive tapering sections, each tapering section having a different, substantially constant, angle of tapering. The balloon is substantially asymmetrical about a mid-point between the first and second ends when inflated.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: October 15, 2019
    Assignee: Brunel University London
    Inventor: Ashraf Khir
  • Patent number: 10441695
    Abstract: A drive device is provided comprising a working pump, the working pump connected to a membrane fluid pump, and the working pump having a working piston able to oscillate axially between two reversal points for contracting and expanding a working chamber, and a control unit for controlling a movement of the working piston between the two reversal points. The controlled movement of the working piston comprises three temporally successive phases, in a first phase the working piston is accelerated to a speed that is greater than a speed at the end of the first phase, in a second phase the working piston is moved such that a specified speed of the working piston, a specified relative pressure in the working chamber, or a specified force of the working piston is substantially kept constant, and in a third phase the working piston is moved at a negative acceleration.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: October 15, 2019
    Assignee: BERLIN HEART GMBH
    Inventor: Robert Steingräber
  • Patent number: 10441696
    Abstract: A dialysis system, comprising: a dialysis machine; an authentication component configured to determine that a source of a voice command received by the dialysis system is an authorized user of the dialysis system; and a processor configured to carry out a function determined based on the voice command.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 15, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Lee Daniel Tanenbaum, Fei Wang, Mario Gumina, Thomas Merics, Eric Hoffstetter, Matthew Doyle, Aleo Nobel Mok, Wayne Raiford
  • Patent number: 10441697
    Abstract: A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: October 15, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Jason A. Demers, Michael J. Wilt, Kevin L. Grant, Shannon Prescott, David E. Collins
  • Patent number: 10441698
    Abstract: A dialysis machine comprising internal fluidics, wherein the internal fluidics includes a dialysis fluid pump for pumping dialysis fluid from a dialysis fluid reservoir through a dialysis fluid feed line to a dialyzer and from the dialyzer through a dialysis fluid drain line to a waste reservoir, a substitution fluid pump for supplying dialysis fluid through a substitution fluid feed line as substitution fluid to an extracorporeal hose system including ports on the patient side and coupling means for connecting the extracorporeal hose system to the internal fluidics is disclosed.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: October 15, 2019
    Assignee: B. Braun Avitum AG
    Inventors: Henrik Wolff, Bjoern Broeker
  • Patent number: 10441699
    Abstract: A blood purification apparatus includes a blood circuit, a dialyzer capable of purifying the blood flowing through the blood circuit, a blood pump provided to an arterial blood circuit and that delivers the blood in the blood circuit, and an air-trap chamber capable of collecting air in the blood flowing through the blood circuit. A peristaltic pump (a substitution-fluid-infusion device) that is capable of infusing a substitution fluid is connected to the air-trap chamber. A substitution fluid layer is formable on a blood layer in the air-trap chamber. The air-trap chamber is provided with a blood-interface-detecting device that is capable of detecting an interface between the blood layer and the substitution fluid layer that are formed in the air-trap chamber. A lack of substitution fluid in the air-trap chamber is detectable on the basis of the interface between the blood layer and the substitution fluid layer that is detected by the blood-interface-detecting device.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: October 15, 2019
    Assignee: NIKKISO COMPANY LIMITED
    Inventor: Hiroaki Mochizuki
  • Patent number: 10441700
    Abstract: A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: October 15, 2019
    Assignee: NXSTAGE MEDICAL, INC.
    Inventors: Goetz Friederichs, William Weigel, Dennis M. Treu, Jeffrey H. Burbank, James M. Brugger, Keith J. Wheeler, Scott W. Newell
  • Patent number: 10441701
    Abstract: A medical apparatus for the preparation of medical fluid is disclosed, comprising a support structure, a movable member, biasing means, and locking means. The movable member is mounted to the support structure and the biasing means are configured to operate in at least one of a repulsion mode and an attraction mode In the repulsion mode, the biasing means exert on the movable member a biasing force directing the movable member away from its retracted configuration, and in the attraction mode, the biasing means exert on the movable member a biasing force directing the movable member towards its retracted configuration. A blood treatment apparatus comprising the medical apparatus for the preparation of fluid, a method of setting up the medical apparatus, and a method for use of the apparatus are also disclosed.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: October 15, 2019
    Assignee: Gambro Lundia AB
    Inventors: Marco Paraluppi, Stefano Micco
  • Patent number: 10441702
    Abstract: Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: October 15, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: William Scott Crawford, Robert Matthew Ohline
  • Patent number: 10441703
    Abstract: A hybrid hemodialysis (“HD”)/peritoneal dialysis (“PD”) system includes: a reservoir; a weigh scale operably coupled with the reservoir; and at least one controller programmed to run (i) an HD treatment in which blood is pumped to a blood compartment of a dialyzer, fresh HD dialysis fluid is pumped to a dialysis fluid compartment of the dialyzer, and used HD dialysis fluid is pumped from the dialysis fluid compartment of the dialyzer to the reservoir, and at a different time (ii) a PD treatment in which fresh PD dialysis fluid is pumped to a patient and used PD dialysis fluid is pumped from the patient to the reservoir.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 15, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
  • Patent number: 10441704
    Abstract: A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: October 15, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Martin Crnkovich, Lee Tanenbaum, Michael Emmanuel Kotsos, Fei Wang, Alex Brown
  • Patent number: 10441705
    Abstract: A medical wetness sensing device includes a base adapted to be disposed on a wearer of the medical wetness sensing device. The base includes a first electrical conductor and a second electrical conductor electrically insulated from the first electrical conductor. The first electrical conductor includes a hinge portion enabling a first portion of the first electrical conductor to deflect, at the hinge portion, relative to a second portion of the first electrical conductor. The medical wetness sensing device includes a controller electrically connected to the first electrical conductor and the second electrical conductor. The controller is configured to detect a presence or an absence of a medical fluid electrically connecting the first and second electrical conductors.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: October 15, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Colin Weaver, Martin Joseph Crnkovich
  • Patent number: 10441706
    Abstract: A fluid processing system for controlling fluid flow comprises a cassette having a defined passageway on a first side. The first side includes flexible sheeting disposed over the passageway. The system comprises a durable processing device configured to engage the first side of the cassette, the durable processing device comprising a valve actuator configured to engage the flexible sheeting at a valve location along the passageway. The system comprises a first pump configured to draw fluid away from the valve location along the passageway. The first pump is disposed downstream of the valve location. The system comprises a second pump configured to pump fluid towards the valve location along the defined passageway. The second pump is disposed upstream of the valve location. The first and second pumps are configured to operate in concert and configured to provide pressure to prevent collapsing of the flexible sheeting against the passageway during operation.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 15, 2019
    Assignee: Fenwal, Inc.
    Inventors: David S. Brown, Sukhraaj Basati
  • Patent number: 10441707
    Abstract: Improved systems and methods for extracorporeal blood temperature control and patient temperature control, e.g., for induced hypothermia and optional normothermia, may include or otherwise employ a heat exchanger for cooling/warming of a fluid, a thermal exchange module having fluidly isolated first and second volumes, and a fluid pump for circulating the fluid through the heat exchanger and the first volume of the thermal exchange module. A blood pump may be provided for the flow of blood through the second volume of the thermal exchange module, and a first controller may be provided for providing output signals for use in operation of the heat exchanger to selectively control thermal exchange between the fluid circulated through the first volume of the thermal exchange module and the blood flowed through the second volume of the thermal exchange module, thereby providing for selective cooling/warming of the blood.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: October 15, 2019
    Assignee: MEDIVANCE INCORPORATED
    Inventors: Marc E. Voorhees, Christopher Park, Salvatore Privitera
  • Patent number: 10441708
    Abstract: An intermediate product (1) for producing a plurality of pre-filled dual-chamber syringes or cartridges includes a support template (2) having an array of support seats and partially pre-filled tubular containment bodies (3), each inserted in a respective support seat. Each of the tubular containment bodies (3) 10 extends between a first (4) and a second opening (5). A sterile package (20-23) encloses the support template (2) and the tubular containment bodies (3) in sterile manner. The interiors of the tubular containment bodies (3) include a first stopper (6) and a second stopper (7) arranged in such a manner as to define therebetween a first containment chamber (8) in the tubular containment body (3) and adapted to slide inside the tubular containment 20 body. A liquid substance is contained inside the first containment chamber (8).
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: October 15, 2019
    Assignee: OROFINO PHARMACEUTICALS GROUP S.r.l.
    Inventor: Ernesto Orofino
  • Patent number: 10441709
    Abstract: A method for using CO2 as a contrast material in medical imaging procedures is disclosed. The method includes providing a source of pressurized CO2. The step of providing includes connecting the source of pressurized CO2 to a compressed gas unit for controlling delivery of the CO2. The method also includes regulating pressure of the CO2 delivered by the compressed gas unit, transmitting the pressurized CO2 from the compressed gas unit to a control valve assembly for delivery to a patient in controlled dosages, and sequentially processing the CO2 with the control valve assembly and delivering the CO2 to the patient as a contrast media.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 15, 2019
    Inventors: Frank Levy, Kimberley Levy
  • Patent number: 10441710
    Abstract: An infusion pump including an interface unit for receiving first data for a first infusion regimen for a medication, the first regimen including a first unit of measure in which the first regimen is executed and after receipt of the first data, second data for a second infusion regimen for the medication, the second regimen including a second unit of measure in which the second regimen is executed. The pump also includes a processor for comparing the first and second units of measure. In one embodiment, the pump includes a graphical user interface, and the processor identifies a difference between the first and second units of measure; generates, using the processor, a warning message; and displays the message on the graphical user interface. In another embodiment, the processor holds in abeyance initiation of the second infusion regimen in response to identifying the difference between the units of measure.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: October 15, 2019
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Roger L. Hungerford, Curt Matthew Allen
  • Patent number: 10441711
    Abstract: A device and a method facilitate connecting a vial to a container or to a fluid, line, and transferring the contents of the vial to the container or to the fluid line. The device has a connecting device, a first holder for accommodating the connecting device, a second holder for accommodating the vial, and an actuating means. The connecting device includes an annular housing, an inside part having at least one puncture device, and a tube connection. The annular housing is configured to be rotatable about the inside part so as to function as a valve, so that by rotation of the annular housing, flow paths of the connecting device can be opened and closed.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: October 15, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Winfried Brehm, Martin Kaiser, Massimo Fini, Alain Veneroni
  • Patent number: 10441712
    Abstract: A device (2) for continuous infusions has a housing (4) in which an infusion appliance seat (6) is provided for receiving an infusion appliance (18) with at least one container (22) that can be pressed empty by means of a ram (20), which infusion appliance seat (6) extends along a main axis of extent (AA) from a ram-side end (26) to an outlet-side end (28). The continuous infusion device (2) moreover has an actuator (30) for automatically emptying the infusion appliance (18), a drive (32) for moving a ram abutment/actuation element (24) of the actuator (30), and a control arrangement (72) by means of which a speed of advance of the actuator (30) is adjustable. Provision is made here that the main axis of extent (AA) of the infusion appliance seat (6) has a predetermined relief angle (W) in relation to a support plane (E) of the housing (4), and here the outlet-side end (28) is arranged above the ram-side end (26) of the infusion appliance seat (6).
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: October 15, 2019
    Assignee: H & B ELECTRONIC GMBH & CO. KG
    Inventors: Tobias Morlok, Wilfried Weber
  • Patent number: 10441713
    Abstract: An injection system for the independent administration of imaging-guided injections utilizing the hand-on-needle technique including a pressure-sensitive pump and a switch assembly is provided. The switch assembly is adjustably mounted to a probe with a releasable mount, and includes a displaceable lever that can be displaced from a neutral position to a first position to initiate an aspiration event at the needle and from a neutral position to a second position to initiate an injection event at the needle. The displaceable lever and the pressure-sensitive pump are in electronic communication with a control module, which includes programmable logic executed by a processor to send and receive electronic communication(s) from the pump and switch, including when to continue and/or terminate aspiration and injection events at the needle.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: October 15, 2019
    Assignee: Anestech, LLC
    Inventors: Daniel Feldman, Ilya Rozin
  • Patent number: 10441714
    Abstract: The application describes a protective case for an auto-injector. The medicament contained within these auto-injectors can be susceptible to degradation due to exposure to extreme temperatures and light. Thus, one embodiment of the protective case reduces the rate of heat transfer between the internal storage compartment of the case and the external atmosphere by including particularly configured vacuum chambers. Additionally, as auto-injectors become smaller, portability can be desirable. Thus, another embodiment of the protective case includes low-profile cases that allow the user to keep the auto-injector with them, e.g., by attaching the case to a common everyday item.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 15, 2019
    Assignee: Pirouette Medical LLC
    Inventors: Elijah Kapas, Matthew Kane, Conor Cullinane
  • Patent number: 10441715
    Abstract: There are disclosed devices and methods for protecting a user from a sharp tip of a medical needle. In an embodiment, a device includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion, and a hook-and-loop fastening system disposed on at least one of the wings, and configured to selectively attach the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle. In another embodiment, a method includes withdrawing a sharp tip of a medical needle from a patient, closing a pair of wings with the medical needle positioned between the wings, and fastening the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 15, 2019
    Assignee: EMED TECHNOLOGIES CORPORATION
    Inventor: Paul Lambert
  • Patent number: 10441716
    Abstract: The control device is used to control delivery of fluids from a multi-fluid delivery system during a medical injection procedure. The fluid delivery system includes an injector used to deliver injection fluids to a patient. The control device is operatively associated with the injector for controlling discrete flow rates of injection fluids delivered to the patient. The control device includes first and second actuators associated with the manual control device, and an electronic substrate disposed within the manual control device and having a conductive pattern. The first actuator is operatively associated with the conductive pattern. The conductive pattern includes a plurality of predetermined digital values corresponding to discrete flow rates of injection fluids to be delivered by the injector.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: October 15, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Ralph H. Schriver, Thomas P. Joyce, Michael Riley, William D. Barlow
  • Patent number: 10441717
    Abstract: A physiological parameter associated with tissue of a host may be monitored in the tissue to confirm subcutaneous delivery of medication to the host. More particularly, such may involve delivering medication subcutaneously to the host with a medical device which includes a sensor used to measure the physiological parameter, particularly within a predetermined time period after delivery of the medication. Such may also or otherwise involve forming a depot in the tissue with the medication, and using the sensor to measure the physiological parameter while the sensor is at least partially within the depot.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: October 15, 2019
    Assignee: Insulet Corporation
    Inventors: Kevin Guido Schmid, Steven Dilanni, Robert W. Campbell, Ian T. McLaughlin, Jason B. O'Connor
  • Patent number: 10441718
    Abstract: An automated wearable device measure physiological signals, and when parameters which cause the wearer to be at risk are measured, the device delivers an antidote for a given medical condition. This prevents overdose or medical conditions from occurring.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: October 15, 2019
    Inventor: David Tchao
  • Patent number: 10441719
    Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes two sections having distal ends with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: October 15, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Yannick Hourman, Douglas Ivan Jennings, Matthew Ekman
  • Patent number: 10441720
    Abstract: Medical syringe having a gasket excellent in sealability and slidability. The syringe includes a hollow cylindrical syringe barrel (11) and a gasket (13) fitted in syringe barrel (11). Gasket (13) includes a main body of an elastic material laminated with an inert resin film and has a circumferential surface portion (17) substantially maintained in contact with an inner surface (16) of syringe barrel (11). Gasket 13 also has an annular projection (22), provided on circumferential surface portion (17), extending circumferentially of circumferential surface portion (17). Projection (22) has a contact surface portion maintained in contact with inner surface (16) of syringe barrel (11) and having a width of 30 ?m to 40 ?m. Circumferential surface portion (17) has non-contact surface portions located out of contact with inner surface (16) of syringe barrel (11) on widthwise opposite sides of projection (22) and having a width of at least 30 ?m.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 15, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yuki Sakashita
  • Patent number: 10441721
    Abstract: The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a dosing element (40, 30), which rotates in a first direction during dose selecting and rotates in a second, opposite direction during dose dispensing, and a display (60) for indicating the selected dose. The display (60) comprises at least one belt (61, 62) having symbols for indicating the selected dose and being coupled to the dosing element (40, 130) such that a rotation of the dosing element (40, 130) spools the belt (61, 62).
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: October 15, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Karl Hewson, Stuart Milne, Mark Pawulski
  • Patent number: 10441722
    Abstract: A drug delivery device comprises an housing, an axially displaceable piston rod, a rotatable drive member, a spring housing, a torsion drive spring coupled to the spring housing respectively the drive member, dose setting means allowing a user to simultaneously set a dose amount to be expelled and strain the torsion drive spring correspondingly by rotation of the drive member, and a release member being axially moveable relative to the housing between a proximal initial position and an actuated distal release position. The spring housing is helically coupled to the housing such that the spring exerts a tangential force on the spring housing to thereby bias the spring housing in the proximal direction, whereby the spring housing thereby exerts a proximally directed biasing force on the release member. The spring housing can be moved helically in the distal direction when a distally directed force is exerted on the release member.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: October 15, 2019
    Assignee: Novo Nordisk A/S
    Inventor: Ebbe Kiilerich
  • Patent number: 10441723
    Abstract: Variable fill drug delivery devices for delivering a therapeutic agent to a patient are provided. A variable fill drug delivery device includes a drug container to store a variable amount (or user-selectable amount) of a therapeutic agent. A plunger of the variable fill drug delivery device is positioned in the drug container. An infusion engine of the variable fill device is coupled to the plunger. The infusion engine retains the plunger prior to activation of the variable fill drug delivery device and releases the plunger after activation of the variable fill drug delivery device. After activation, the infusion engine drives the plunger from a first position within the drug container to a second position within the drug container to expel the variable amount of the therapeutic agent from the drug container for delivery to a patient.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: October 15, 2019
    Assignee: Insulet Corporation
    Inventor: David Nazzaro
  • Patent number: 10441724
    Abstract: A drive mechanism for a delivery device is presented. The drive mechanism comprises a housing (24) and a piston rod (6) having a longitudinal axis (x) and a piston rod feature (17). The drive mechanism further comprises a drive member (1) being movable with respect to the housing (24). The drive member (1) comprises a drive feature (15). The drive feature (15) is selectively engageable with the piston rod feature (17) by the radial displacement of the drive member (1) with respect to the piston rod (6). When the drive member (1) is in the first position, the drive member (1) is disengaged from the piston rod (6), and when the drive member (1) is in the second position, the drive feature (15) is engaged with the piston rod feature (17). When the drive member (1) moves distally with respect to the housing (24), said distal movement is transferred to the piston rod (6) such that the piston rod (6) moves distally with respect to the housing (24).
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: October 15, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Matt Schumann, Stuart Milne
  • Patent number: 10441725
    Abstract: A dose setting mechanism for a drug delivery device includes a primary drug delivery assembly and a secondary drug delivery assembly. The dose setting mechanism includes a primary dose dial component for setting a dose in the primary drug delivery assembly and a secondary dose dial component for setting a dose in the secondary drug delivery assembly. The primary dose dial component and the secondary dose dial component are configured to rotate during dose setting. A gear mechanism is configured such that in a first phase of the dose setting, rotation of the primary dose dial component is transferred to the secondary dose dial component and such that in a second phase of the dose setting, the secondary dose dial component is decoupled from the primary dose dial component such that rotation of the primary dose dial component is prevented from being transferred to the secondary dose dial component.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: October 15, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Matthew Meredith Jones, Samuel Keir Steel, Neal Alexander Blundred, Joseph Butler, Robert Frederick Veasey, David Plumptre