Patents Issued in October 17, 2019
  • Publication number: 20190314316
    Abstract: Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 17, 2019
    Inventor: Tianxin YANG
  • Publication number: 20190314317
    Abstract: The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating various skin disorders.
    Type: Application
    Filed: June 24, 2019
    Publication date: October 17, 2019
    Inventors: Adam Kelliher, Angus Morrison, Phil Knowles
  • Publication number: 20190314318
    Abstract: Combinations of betaine and vitamin C are used to suppress or prevent malignant tumors or to treat viruses, e.g., by combining the two ingredients in a product consumed by a human, dog, or cat, such as an aqueous liquid such as grape juice, the ingredients being provided in containers with instructions for use, or in finished products, especially with support of tests demonstrating the effectiveness of the treatment for, e.g., preventing tumors in populations known to be at risk of developing tumors, or, treating existing cancers in combination with other cancer drugs such as anastrozole and/or fulvestrant and/or artemisinin either concurrently or sequentially to prevent the cancer from growing when the cancer drug is not being used, or in the treatment of viruses.
    Type: Application
    Filed: April 11, 2018
    Publication date: October 17, 2019
    Inventors: Robert Benson Aylor, Leigh Heather Makover, Robyn Aylor Haines
  • Publication number: 20190314319
    Abstract: The present disclosure provides certain combination therapy technologies that are particularly useful for treating one or more diseases, disorders, or conditions that may be related to abnormal metabolism. In some embodiments, provided technologies provides combinations of TCA cycle acids and ketone bodies. In some embodiments, provided technologies provides combinations of TCA cycle acids and other carboxylic acids.
    Type: Application
    Filed: February 23, 2017
    Publication date: October 17, 2019
    Inventor: Andrew D. Levin
  • Publication number: 20190314320
    Abstract: The present invention provides a means for treating and/or preventing peripheral nerve disorder by facilitating regeneration of peripheral nerves. Specifically, the present invention provides a composition for treating and/or preventing peripheral nerve disorder comprising a compound represented by the general formula (I): wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa): R4?O—R5?m??(IIa) wherein R4 is lower alkyl, R5 is lower alkylene, and m is an integer of 1 to 6; R2 is lower alkyl optionally substituted with phenyl; and R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 17, 2019
    Applicants: OSAKA CITY UNIVERSITY, SENJU PHARMACEUTICAL CO., LTD.
    Inventor: Shinji HIROTSUNE
  • Publication number: 20190314321
    Abstract: The use of a genetic method to down-regulate RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIII? enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIII? protein kinase activity reduces the accumulation of A?42 within neurons and age-dependent synaptic transmission failure and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIII? inhibitor to treat Alzheimer's disease. Also provided is a method for screening a drug treating Alzheimer's disease by whether A? secretion by nerve cells is promoted or not.
    Type: Application
    Filed: May 3, 2016
    Publication date: October 17, 2019
    Inventors: Fude Huang, Xiao Zhang, Wenan Wang, Le Zhang, Lixiang Jiang, Tong Zhu, Haiyan Liu, Yudong Zhou, Yang He, Wanguo Wei
  • Publication number: 20190314322
    Abstract: Disclosed herein is a method for treating infection by an enteropathogen and/or enhancing growth performance, which includes administering to a subject in need thereof a composition containing a ferrous amino acid chelate. Also disclosed herein is an animal feed containing the ferrous amino acid chelate.
    Type: Application
    Filed: December 20, 2018
    Publication date: October 17, 2019
    Inventors: Tsun-Yuan LIN, Mu-Kuei CHEN, Kai-Ting WANG, Hsun-Jin JAN
  • Publication number: 20190314323
    Abstract: Campylobacter are the commonest reported bacterial causes of gastroenteritis in the UK and industrialized worlds. This invention relates to a method of preventing or reducing the colonisation of the gastrointestinal tract of an animal with. Accordingly, the present invention provides a method for disinfection of an animal comprising administering to said animal at least one compound that binds to MOMP or FlaA of in an effective amount to reduce the number of Campylobacter present in the gastrointestinal tract of said animal. The present invention also provides a method of preventing or reducing transmission of from one animal to another.
    Type: Application
    Filed: February 4, 2019
    Publication date: October 17, 2019
    Inventors: Jafar Mahdavi, Dlawer Ala'Aldeen
  • Publication number: 20190314324
    Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.
    Type: Application
    Filed: April 11, 2019
    Publication date: October 17, 2019
    Inventors: Wenbin Lin, Christina Chan, Wenbo Han
  • Publication number: 20190314325
    Abstract: This invention provides compositions and methods for cellular regeneration and more rapid healing of surface lesions such as cuts, abrasions, rashes and other skin disturbances. A preferred consumer-based and battlefield embodiment features a spray-on composition delivering at least one substance that stimulates intercellular communication using tunneling nanotubes (TNTs). The induced TNTs increase transport of chemical and/or electrochemical information between more stable and nascent cells or between more intact and damaged cells. The inventive substance is applicable for use for ordinary household type injuries as well as industrial and/or battlefield events, perhaps from physical or chemical accidents or even several types of chemical weapons. Other preferred embodiments incorporate a sealant composition or coating to shield the affected surface area designated for healing from contamination and/or solvents/carriers to facilitate transdermal delivery of one or more pharmaceutically active ingredients.
    Type: Application
    Filed: December 28, 2018
    Publication date: October 17, 2019
    Inventor: Richard Postrel
  • Publication number: 20190314326
    Abstract: Provided are cannabinoid-loaded formulations, as well as processes for their preparation.
    Type: Application
    Filed: September 28, 2017
    Publication date: October 17, 2019
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim GARTI, Sharon GARTI LEVI, Rotem EDRI
  • Publication number: 20190314327
    Abstract: A pharmaceutical composition comprising cannabis for improving digestion and/or treating the symptoms associated with gastrointestinal complications in a patient. Also provided is a use of the pharmaceutical composition for improving digestion and/or treating the symptoms associated with gastrointestinal complications in a patient, and a method for improving digestion and/or treating the symptoms associated with gastrointestinal complications. The pharmaceutical composition preferably includes a combination of therapeutically effective amount of one or more of the following medicinal ingredients: cannabis and/or an enzyme.
    Type: Application
    Filed: April 5, 2019
    Publication date: October 17, 2019
    Inventor: Pardeep Nijhawan
  • Publication number: 20190314328
    Abstract: Mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) are provided as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse, including control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Szabolcs PETER, Joseph SCHWAGER
  • Publication number: 20190314329
    Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 17, 2019
    Inventors: Mark G. Frattini, Hakim Djaballah, Thomas J. Kelly
  • Publication number: 20190314330
    Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
    Type: Application
    Filed: June 3, 2019
    Publication date: October 17, 2019
    Inventors: Qingping ZENG, Andras TORO, John Bruce PATTERSON, Warren Stanfield WADE, Zoltan ZUBOVICS, Yun YANG, Zhipeng WU
  • Publication number: 20190314331
    Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Seth Cabot Hopkins, Kenneth Stephen Koblan, John R. Snoonian, Harold Scott Wilkinson
  • Publication number: 20190314332
    Abstract: A method administers quaternary ammonium anti-cholinergic muscarinic receptor antagonists in combination with acetyl-cholinesterase inhibitors to treat either cognitive impairment or acute delirium. This therapy results in a modification of a cognitive disorder or disease, namely a slow down in the disease progression. In one preferred embodiment, the disease is dementia with Lewy Bodies. New formulations for quaternary ammonium anti-cholinergic muscarinic receptor antagonists are also disclosed.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Inventor: Steven A. Rich
  • Publication number: 20190314333
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: December 17, 2018
    Publication date: October 17, 2019
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Publication number: 20190314334
    Abstract: The present invention refers to the use of compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein R1 and R2 represent, independently of each other: an optionally substituted phenyl ring, or an optionally substituted 5-membered heteroaromatic ring; one of R3 and R4 is H and the other represents a group wherein W is OH or an ortho-aniline group; each A, independently of each other, represents a —CH2— group or is absent; ?Y—Y? is ?HC—CH?, ?N—CH?, or ?HC—N?; or a salt or solvate thereof, in the prevention or treatment of an autoimmune disease.
    Type: Application
    Filed: November 7, 2017
    Publication date: October 17, 2019
    Inventors: Yosu Ion VARA SALAZAR, Eneko ALDABA ARÉVALO, Ferdinando NICOLETTI, Massimo LIBRA, Katia Domenica MANGANO
  • Publication number: 20190314335
    Abstract: An object of the present invention is to provide a lipid particle composition containing panobinostat or a salt thereof and exhibiting a high bone marrow-targeting capability, and a pharmaceutical composition including the lipid particle composition. According to the present invention, provided is a lipid particle composition containing panobinostat or a salt thereof, in which a lipid particle contains a phospholipid and cholesterol.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 17, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Yuta YOSHINO, Hayato OGURA, Mikinaga MORI, Taisuke ENDO, Kentaro NUMAJIRI, Ritsuko HORI
  • Publication number: 20190314336
    Abstract: The present invention relates to a parenteral liquid preparation containing, as active ingredients; a carbamate compound of chemical formula 1, an isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof; and a cyclodextrin derivative.
    Type: Application
    Filed: December 14, 2017
    Publication date: October 17, 2019
    Inventors: Myoung Ki BAEK, Ji Hye LEE, So Young CHOI
  • Publication number: 20190314337
    Abstract: The present invention relates to a use for the purpose of preventing, alleviating, or treating bipolar disorder by administering a pharmaceutical composition comprising a carbamate compound of the following chemical formula 1.
    Type: Application
    Filed: December 14, 2017
    Publication date: October 17, 2019
    Applicant: SK BIOPHARMACEUTICALS CO., LTD.
    Inventors: Yu Jin SHIN, Sei Myoung HAN
  • Publication number: 20190314338
    Abstract: The present invention relates to a use for preventing, alleviating or treating a demyelinating disease by administering a pharmaceutical composition containing a carbamate compound of chemical formula 1.
    Type: Application
    Filed: December 14, 2017
    Publication date: October 17, 2019
    Inventors: Sun Gwan HWANG, Jihye KIM, Jimok YOON
  • Publication number: 20190314339
    Abstract: The present invention provides a drug capable of preventing or treating diabetic nephropathy. The present invention relates to a prophylactic and/or therapeutic drug for diabetic nephropathy, comprising a RAR? agonist as an active ingredient. The present invention also provides a prophylactic and/or therapeutic drug for renal anemia; a drug inhibiting the expression of type IV collagen in mesangial cells; a drug inhibiting the expression of BMP4 in mesangial cells; and a drug inhibiting fibrosis in the renal tubulointerstitium.
    Type: Application
    Filed: April 2, 2019
    Publication date: October 17, 2019
    Applicants: HuBit Genomix, Inc., Fuso Pharmaceutical Industries, Ltd.
    Inventors: Toshio Doi, Tatsuya Tominaga, Yui Fujita
  • Publication number: 20190314340
    Abstract: An antimicrobial composition containing a synergistic combination of an imidazole antifungal agent and activated creatinine is provided, wherein the imidazole antifungal agent represents in the range of about 0.5 mol % to about 30 mol % of the combination of the antifungal agent and the activated creatinine in the composition. Methods for treating bacterial infections, fungal infections, viral infections, and wounds are also provided, as are other methods of use, including methods for disinfecting inert surfaces, methods for preserving food products, and methods for treating plants. In addition, the invention provides a method for enhancing the antifungal effect of an imidazole antifungal agent as well as a method for enhancing the antibacterial effect of activated creatinine. Compositions and methods involving use of activated 2-amino-imidazol-4-one analogs other than activated creatinine are also provided.
    Type: Application
    Filed: December 27, 2017
    Publication date: October 17, 2019
    Inventors: Thomas McDonald, Steven M. Tracy
  • Publication number: 20190314341
    Abstract: Dietary supplement compositions directed to men and women and to the maintenance and improvement of human physiology, including weight, skin, hair, and general organ function and sexual health.
    Type: Application
    Filed: April 16, 2019
    Publication date: October 17, 2019
    Applicant: Serendipity Technologies LLC
    Inventor: Amen Dhyllon
  • Publication number: 20190314342
    Abstract: The invention relates to the use of biotin for treating Amyotrophic Lateral Sclerosis, as well as demyelinating peripheral neuropathies and Neuromyelitis optica (NMO).
    Type: Application
    Filed: June 25, 2019
    Publication date: October 17, 2019
    Applicant: MedDay Pharmaceuticals
    Inventor: Frédéric SEDEL
  • Publication number: 20190314343
    Abstract: The present application relates to topical formulations comprising Compound-I or its free base, and a second active agent selected from nicotinic acid, nicotinamide, and vitamin K, and a combination thereof, for treating ocular neovascularization. The present application also relates to pharmaceutical compositions comprising particles of Compound-I or its free base, and suspension formulations comprising the particle compositions of Compound-I or its free base.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 17, 2019
    Inventors: David P. BINGAMAN, Paul G. CHANEY, Martin B. WAX
  • Publication number: 20190314344
    Abstract: The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. In particular embodiments, the present invention provides a method for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of an agent that mobilizes CD34+ and/or CD133+ stem cells and a low dose of an immunosuppressive agent.
    Type: Application
    Filed: July 31, 2015
    Publication date: October 17, 2019
    Inventors: Zhaoli Sun, Xuhang Li
  • Publication number: 20190314345
    Abstract: The present invention relates to compositions and methods for targeted administration to the pancreas of a calcineurin inhibitor and a non-steroidal anti-inflammatory drug (“NSAID”) to reduce the risk and/or limit the extent of post-imaging pancreatitis associated with procedures that employ a radiocontrast medium, particularly procedures that selectively image the pancreas, gallbladder and/or biliary tree.
    Type: Application
    Filed: April 24, 2019
    Publication date: October 17, 2019
    Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventor: Sohail HUSAIN
  • Publication number: 20190314346
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 17, 2019
    Inventors: Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Saleem Ahmad, Wei Meng, Robert Paul Brigance, Pratik Devasthale, Guohua Zhao
  • Publication number: 20190314347
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: November 3, 2017
    Publication date: October 17, 2019
    Inventors: Danielle Lauren BAILEY, Yingzhi BI, Shuai CHEN, Bruce D. DORSEY, Dimitar B. GOTCHEV, Richard James HOLLAND, Ramesh KAKARLA, Duyan NGUYEN, Mark Christopher WOOD
  • Publication number: 20190314348
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 17, 2019
    Inventors: Ha-Soon Choi, James Paul Lajiness, Srinivasa Reddy Natala, Bao Nguyen, Hank Michael James Petrassi, Zhicheng Wang
  • Publication number: 20190314349
    Abstract: Provided are a pyridone derivative pharmaceutical composition and a preparation method thereof. In particular, provided are a pharmaceutical composition containing a pyridone derivative or a pharmaceutically acceptable salt thereof and the preparation method thereof. The pharmaceutical composition contains an active ingredient 2-((2-fluoro-4-iodophenyl)amino)-1-methyl-4-((6-methylpyridin-3-yl)oxy)-6-oxo-1,6-di hydropyridine-3-carboxamide or a pharmaceutically acceptable salt thereof, and hydroxypropyl methylcellulose, and the pharmaceutical composition has good dissolution.
    Type: Application
    Filed: November 24, 2017
    Publication date: October 17, 2019
    Inventors: Huan DING, Daimei ZHANG
  • Publication number: 20190314350
    Abstract: A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Applicant: Acorda Therapeutics, Inc.
    Inventors: Andrew R. Blight, Ron Cohen
  • Publication number: 20190314351
    Abstract: Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering to a patient pirfenidone at doses lower than the full target dosage for a time period, followed by administering to the patient pirfenidone at the full target dosage. The methods also include administering pirfenidone at the full target dose with no reduction and administering permanently reduced doses of pirfenidone.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 17, 2019
    Inventors: Williamson Z. Bradford, Javier Szwarcberg
  • Publication number: 20190314352
    Abstract: Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1 (2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the pharmaceutical compositions as well as methods of using the pharmaceutical compositions.
    Type: Application
    Filed: February 15, 2019
    Publication date: October 17, 2019
    Inventors: Ronald J. Christopher, Paul Covington
  • Publication number: 20190314353
    Abstract: The present invention relates to dispersible tablets compris-ing the compound (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-l, l-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceuti-cally acceptable salt thereof.
    Type: Application
    Filed: April 15, 2019
    Publication date: October 17, 2019
    Inventors: Frantz Elbaz, Charu Kochhar, Doris Stingelin, Michaela Anna Maria Bock
  • Publication number: 20190314354
    Abstract: A combination of a muscarinic cholinergic receptor agonist, a non-anticholinergic antiemetic agent and a non-selective, peripheral anticholinergic agent for the treatment of hypocholinergic disorders of the central nervous system.
    Type: Application
    Filed: April 23, 2019
    Publication date: October 17, 2019
    Applicant: Chase Pharmaceuticals Corporation
    Inventors: Thomas N. CHASE, Kathleen E. CLARENCE-SMITH
  • Publication number: 20190314355
    Abstract: Provided are methods for treating, ameliorating, reversing and/or preventing a Helicobacter pylori (H. pylori) infection in an individual in need thereof, comprising: administering to the individual in need thereof a therapeutic combination comprising: (a) a composition comprising or consisting of: vonoprazan or a vonoprazan fumarate, or a 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine monofumarate, or a 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methyl-methanamine fumarate), optionally TAKECAB™; and (b) an antimicrobial or antibiotic drug or composition.
    Type: Application
    Filed: June 25, 2019
    Publication date: October 17, 2019
    Inventor: Thomas Julius BORODY
  • Publication number: 20190314356
    Abstract: The present invention generally relates to treating attention-deficit disorders (e.g., ADHD) by providing an effective amount of an ADHD-effective agent to a patient in need thereof (e.g., a child).
    Type: Application
    Filed: October 31, 2017
    Publication date: October 17, 2019
    Inventors: Mark TENGLER, Nathan TEUSCHER
  • Publication number: 20190314357
    Abstract: Methods for treating cancer by administration of two or more therapeutic agents are provided. The two or more therapeutic agents include a cyclin-dependent kinase inhibitor (e.g., alvocidib) and an anthracycline (e.g., daunorubicin or idarubicin). Kits comprising the two or more therapeutic agents that can be used to perform such methods are also provided.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 17, 2019
    Inventors: David J. Bearss, Steven L. Warner, Clifford J. Whatcott
  • Publication number: 20190314358
    Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands of the NR2B receptor and may be useful for the treatment of various disorders of the central nervous system.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Inventors: Dalton King, Lorin A. Thompson, III, Jianliang Shi, Srinivasan Thangathirupathy, Jayakumar Sankara Warrier, Imadul Islam, John E. Macor
  • Publication number: 20190314359
    Abstract: The present invention relates to novel 2-primary amino-4-secondary amino-quinoline derivatives, their manufacture, pharmaceutical compositions comprising them and their use as medicaments. The active compounds of the present invention are useful for the treatment and prevention of proliferative neoplastic and non-neoplastic diseases.
    Type: Application
    Filed: October 26, 2015
    Publication date: October 17, 2019
    Inventors: Firas BASSISSI, Antoine BERET, Sonia BRUN, Jérôme COURCAMBECK, Clarisse DUBRAY, Gregory NICOLAS, Philippe HALFON
  • Publication number: 20190314360
    Abstract: It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain. An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: wherein R1 represents a C1-6 alkyl group, etc.; R2 represents a hydrogen atom, etc.; R3 represents a halogen atom, etc.; Z1, Z2 and Z3 each represent CH, etc.; X1 represents CONH, etc.; Ring A represents a phenyl group, etc.; R4 represents a halogen atom, etc.; and m represents an integer from 0 to 5.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Applicants: FUJIFILM Corporation, FUJIFILM Toyama Chemical Co., Ltd., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Keiko MAKITA, Kazunori SAEKI, Tadashi TANAKA, Masataka FUJINO, Tohru NATSUME, Kentaro FURUYA
  • Publication number: 20190314361
    Abstract: The application pertains to pharmaceutical combinations of orally administered paclitaxel and a P-gp inhibitor. The pharmaceutical combinations are suitable for the treatment of an angiosarcoma in a subject and for reducing or preventing toxicity, hypersensitivity-type infusion reactions, and other negative outcomes resulting from or associated with intravenously administered paclitaxel (e.g., Taxol® or paclitaxel formulated with Cremophor®) therapy in a subject suffering from an angiosarcoma.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 17, 2019
    Inventors: Min-Fun Rudolf KWAN, Johnson Yiu-Nam LAU, Wing Kai CHAN, Michael P. SMOLINSKI
  • Publication number: 20190314362
    Abstract: A pharmaceutical composition and a therapeutic method wherein an antibody-drug conjugate and an immune checkpoint inhibitor are administered in combination, and the antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to the antibody via a thioether bond; and a pharmaceutical composition and a therapeutic method for use in treatment of a disease that can be ameliorated through an antitumor immunity-activating effect wherein the antibody-drug conjugate is included.
    Type: Application
    Filed: December 11, 2017
    Publication date: October 17, 2019
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Tomomi IWATA, Chiaki ISHII, Teiji WADA, Saori ISHIDA, Yasuki KAMAI
  • Publication number: 20190314363
    Abstract: The present application relates to compositions, kits, uses, systems and methods of using naltrexone and bupropion, or pharmaceutically acceptable salts thereof, for reducing the risk of adverse cardiovascular outcomes or events, including Major Adverse Cardiovascular Events (MACE) in subjects, preferably those at increased risk of adverse cardiovascular outcomes or MACE, that may be overweight or obese. The present application also relates to compositions, kits, uses, systems and methods of using naltrexone and bupropion or pharmaceutically acceptable salts thereof for treatment of overweight or obesity in subjects, preferably at increased risk of adverse cardiovascular outcomes or MACE, wherein the treatment reduces the risk of MACE.
    Type: Application
    Filed: March 18, 2019
    Publication date: October 17, 2019
    Inventors: Preston Klassen, Kristin Taylor
  • Publication number: 20190314364
    Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 17, 2019
    Applicant: Rhodes Technologies
    Inventors: C. Frederick M. HUNTLEY, Erik Wayne KATAISTO, Helge Alfred REISCH, Archana SHARMA
  • Publication number: 20190314365
    Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
    Type: Application
    Filed: June 24, 2019
    Publication date: October 17, 2019
    Applicant: Wyeth, LLC
    Inventors: Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen