Abstract: The invention relates to an injection unit, preferably a pen-shaped injection unit, for administering or delivering a fluid product. The injection unit comprises a housing, an axially movable piston rod mounted in the housing in a non-rotatable manner, a delivery apparatus having a threaded nut that is able to move the piston rod in order to deliver product, a dosing device having a dosing sleeve, a rotary knob, a discharge button arranged coaxially on the dosing sleeve, and a receptacle for the product. The dosing device is connected to the delivery apparatus via a coupling mechanism, wherein the coupling mechanism includes of at least two coupling surfaces that each carry a toothing comprising teeth, wherein the coupling surfaces are used to generate an acoustic and/or tactile signal corresponding to the set or corrected dose of the product to be administered during the dosing operation or during correction of the dose.

Abstract: An apparatus for recording the amount of medicament ejected from an injection device includes a processor to receive information from a primary sensor and a secondary sensor and a memory. The primary sensor is configured to detect information displayed or generated by said injection device and to generate output corresponding thereto. The secondary sensor is configured to detect ejection of medicament from said injection device. The processor is configured to process the output generated by the primary sensor and to record in the memory information indicative of an amount of medicament ejected from said injection device only when the processor determines, on the basis of information received from the secondary sensor, that more than a predetermined amount of medicament has been ejected.

Abstract: An assembly for a drug delivery device is provided, the assembly comprising a feedback feature. The feedback feature is configured to indicate an end of the dispense operation to a user by giving an audible and/or tactile feedback.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), and a piston rod (30) coupled to the housing (10) and to a drive sleeve (40). Rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10). The piston rod (30) is coupled to the housing (10) via a threaded interface (16, 31) with at least two different pitches.

Abstract: The present disclosure relates to a drug delivery device, comprising a housing, a cartridge, the cartridge containing a drug in a quantity sufficient for a plurality of doses of the drug, a bung, the bung being movably retained within the cartridge to dispense a dose of the drug from the cartridge upon movement of the bung with respect to the cartridge, and a drive mechanism, the drive mechanism being operable to transfer a driving force to the bung to dispense the dose of the drug from the cartridge. The drug delivery device is configured such that the maximal driving force which is transferrable to the bung via the drive mechanism varies and is adjusted to the current position of the bung within the cartridge.

Abstract: A safety device for a pre-filled syringe is proposed that comprises a hollow support body with a helical groove formed into an inner surface thereof, a mounting collar for mounting the pre-filled syringe to the support body, a spinning collar with a helical tongue formed to an outer surface thereof and a torsion spring. The helical groove accommodates the helical tongue. Upon release, the torsion spring is capable of exerting a torque upon the spinning collar which causes the spinning collar to rotate within the support body. The engagement of the helical groove and the helical tongue redirects the rotational movement of the spinning collar to a translatory movement that moves the mounting collar in a proximal direction.

Abstract: A needle attachment and detachment assist device includes a frame body, a syringe guide jig, and a needle guide jig. A guide hole is formed in the syringe guide jig. In the needle guide jig, a needle insertion hole is formed on a central axis of the guide hole. The needle insertion hole includes a center hole portion and a rib guide groove. When a syringe is inserted into the guide hole, and a needle member is further inserted into the needle insertion hole, rotation prevention of the needle member is achieved. In this state, when the syringe is rotated in a first direction, the needle member can be clamped to a thread portion of the syringe. When the syringe is rotated in a second direction, the needle member can be loosened.

Abstract: In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range.

Abstract: The present disclosure relates to systems and methods for producing a consistent and effective herbal vapor. A sealed container pod may include a chamber wall defining an internal volume within which a pre-processed herbal composition (e.g., cannabis) is located. The container pod may include filters for the vapor produced from the herbal composition. The container pod may also include a support member for holding and evenly distributing the herbal composition within the internal volume during vaporization. A vaporizer may be configured to obtain information regarding the contents of the herbal composition. The vaporizer may expose the herbal composition to an automated series of timed temperature adjustments specifically tailored for producing a desirable herbal vapor. The herbal vapor may be collected into a bag and/or canister for subsequent consumption.

Abstract: A method of synchronizing a feature between an electronic vapor provision system and a mobile communication device of a user includes obtaining a current parameter of a configurable feature on one of the electronic vapor provision system and the mobile communication device; communicating an indication of the parameter to the other of the electronic vapor provision system and the mobile communication device; and the other one of the electronic vapor provision system and the mobile communication device reconfiguring a corresponding feature in response to the communicated indication of the parameter.

Abstract: A breathing assistance apparatus has a pressurised gases source featuring a lightweight impeller with a plastic shaft. The impeller is shroudless. The plastic shaft is supported within the stator by a bearing structure. A resilient motor mount couples the stator and the housing and provide compliance and/or damping for the motor.

Abstract: The present invention relates to a patient interface (10) for delivering a flow of breathable gas to a patient (12), comprising: a sealing portion (22) for sealing an interface between the patient interface (10) and a patient's face when the patient (10) interface is worn by the patient (12); a detection unit (30) including a displacement sensor (32, 32?) for generating a displacement signal including information on a displacement of the sealing portion (22) with respect to the patient's face relative to an identified reference position of the sealing portion (22) with respect to the patient's face; one or more actuators (36, 36?, 36?) for positioning at least parts of the sealing portion (22) relative to the patient's face; and a control unit (34) that is configured to actuate the one or more actuators (36, 36?, 36?) based on the displacement signal in order to adjust a position of at least parts of the sealing portion (22) with respect to the patient's face during use.

Abstract: A housing and method of using the same is configured and coupled to an aerosol generator which delivers aerosol into an oxygen stream transporting both to a patient via a nasal cannula, in a way to minimize condensation at low liters per minute flow rate.

Abstract: A respiratory nosepiece (10) and method of manufacturing the respiratory nosepiece, the respiratory nosepiece including a first nasal prong (110) with a first channel (112) extending there through, and a first side port (130) connectable to tubes (192, 194) having different first and second diameters. The first side port has a second channel (131) extending there through and in communication with the first channel. The second channel includes a first section (134) having the first diameter, a second section (136) having the second diameter, a first step (135) between the first and second sections, and a second step (137) between the second section and an end (133) of the second channel. The first and second channels are formed during injection molding by pins (412, 422, 431, 441) having flat pin-on-pin geometry to reduce resin flash within the channels.

Abstract: A patient transfer device is configured for use with at least one host device which is capable of providing respiratory support to a patient. The patient transfer device includes an inspiratory port and an expiratory port which are configured to pneumatically connect to the host. An inspiratory connection is pneumatically connected to the inspiratory port and an expiratory connection is pneumatically connected to the expiratory port. An inspiratory valve is coupled between the inspiratory port and the inspiratory connection and expiratory valve is coupled between the expiratory port and the expiratory connection. The inspiratory valve and the expiratory valve are operable between first configurations that permit flow there though and second configurations that occlude flow through the valves. The inspiratory valve and the expiratory valve are configured to operate in the second configuration when the patient transfer device is disconnected from the at least one host device.

Abstract: An adjustable heat and moisture exchanger (HME) for use with a breathing apparatus to humidify air comprising: an inlet for coupling to a source of air, and an outlet for delivering air to a patient and an air flow path between them, HME material in the flow path with two or more surfaces exposed to the air flow path to exchange humidity between patient air flow and an inlet air flow, at least one adjuster for adjusting the configuration of the HME material and/or the air flow to alter the air flow over the surfaces of the HME material to alter the exchange of humidity.

Abstract: Systems and methods for controlling environmental illumination relative to circadian function of individuals are provided. A method is provided for controlling the operation of light sources by assigning a circadian state to the individual based on received electronic information, extrapolating future circadian states based on the assigned circadian state, the assigned circadian state or the extrapolated future circadian states including at least a biological night state, and encoding machine-level control commands that control the operation of the light source for transmission to the light sources adapted for the biological night state by having circadian-significant attenuation along the circadian active wavelength range.

Abstract: A catheter includes a tubular inner layer, a reinforcing layer disposed at least partially within the inner layer or on an outer circumference of the inner layer, and an outer layer. The reinforcing member is made of wound wires, each adjacent pair of the wires having a gap therebetween. A bonding portion is disposed in the gap of the reinforcing layer and includes an inner layer protruding portion of the inner layer that extends into the outer layer and is engaged with an outer layer protruding portion of the outer layer that extends into the inner layer. This configuration enlarges the area across which the outer layer and the inner layer are bonded to each other within the gap of the reinforcing layer, leading to a strengthened bond between the outer layer and the inner layer.

Abstract: A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into a common carotid artery through the internal lumen of the arterial access sheath. The catheter has an overall length and a distal most section length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.

Abstract: A catheter apparatus may have a flexible shaft, guidewire lumens passing through the shaft, and a positioning device for positioning the guidewires relative to an external lumen. The positioning device may be an expansible scaffold covered with a retractable sheath. The positioning device may also be one or more balloons that are inflated through an inflation port in the shaft. The catheter apparatus may be operated by inserting a guide catheter into a vasculature with a chronic total occlusion, inserting the catheter apparatus into the guide catheter, and advancing the guidewires through the guidewire lumens and into contact with a chronic total occlusion. The positioning device may be activated before and/or between attempts to pass the guidewires through the chronic total occlusion to interrogate various parts of the chronic total occlusion.

Abstract: A device for protecting an umbilical stump-catheter interface, includes: a shield having a wall that defines a cavity for accommodating an umbilical stump, wherein the shield further includes a base for attachment to a patient; and an opening at the shield for allowing an umbilical catheter to extend therethrough. A method for protecting an umbilical stump-catheter interface, includes: providing a device having a shield with a wall that defines a cavity for accommodating an umbilical stump, wherein the shield further includes a base for attachment to a patient, and wherein the device further includes an opening at the shield; shielding the umbilical stump from an environment using the shield; and accommodating an umbilical catheter using the opening at the shield.

Abstract: Some embodiments of a medical device anchor system include an anchor device that receives a catheter (or other medical instrument) and secures the catheter in place relative to a skin penetration point. In some embodiments, the anchor device can secure the catheter in an operative position relative to the skin penetration point without the use of sutures or skin tapes.

Abstract: A guide wire includes a core shaft and a coil body covering an outer surface of a distal portion of the core shaft. The coil body includes a straight section that extends in a straight state from a proximal end of the coil body toward a distal end of the coil body, and a bent section arranged at a distal end of the straight section. The coil body may be formed by winding at least one element wire into a helical coil structure, or by winding a plurality of stranded wires (obtained by stranding a plurality of element wires) into a helical coil structure. The element wires and/or the stranded wires of the coiled body are in contact with each other on a side of the bent section opposite to a side toward which the bent section is bent relative to an axial direction of the straight section.

Abstract: A serration balloon can have a number of different components and can be made in a number of different manners. One or more longitudinally extending members with periodic raised wedges can be attached to a medical balloon. They can be attached with a fiber coating, a polymer coating, or other methods. A polymer matrix can be used to bond the longitudinally extending member to the surface of the balloon. The fiber coating can be, for example, a thread or mesh that secures the longitudinally extending member to the balloon. The medical balloon can be an angioplasty balloon, such as an off-the-shelf angioplasty balloon.

Abstract: A device and system for flushing a shunt catheter utilizes the available cerebrospinal fluid (CSF) to flush a blocked catheter. The CSF is pressurized to a predetermined amount and then allowed to suddenly, rapidly and forcefully purge any occlusions. The rapid release of CSF produces flow jets from the catheter pores into the ventricle. This impulse, or “cough”, will push and divert choroid plexus and/or other blockages away from the pores. The device and system may then be allowed to refill at a slow rate, thus reducing the possibility of rapid suction of fluid back into the system and the attendant possibility of drawing the choroid plexus back into the pores. The catheter at the proximal end may also include back-up pores that can be opened to restart flow from the ventricle should the primary pores remain blocked after a flushing attempt.

Abstract: Dilators, such as rapid exchange dilators, configured for percutaneous access are disclosed. The dilator may be configured to be disposable within, or couplable with, a catheter. In some embodiments, the dilator, or the coupled dilator and the catheter, may be configured such that a sheath is not required for percutaneous access. In other embodiments, the dilator may comprise a plug such that a guide wire may be directed from a distal end of the dilator through a port, such as a rapid exchange port, in a sidewall of the dilator. The plug may also be configured to permit passage of fluid through a lumen of the dilator while inhibiting passage of the guide wire through a length of the dilator.

Abstract: Embodiments are disclosed for an applicator used for inserting flowable pharmaceutical preparations into a body cavity, an adapter for connecting a jar to a cavity dispenser, a jar dispenser with a nozzle for automated transferring and dispensing of flowable pharmaceutical compositions, and a metered dial-dispenser configured to connect to a cavity dispenser for humans and animals.

Abstract: A moisturizer formulation for topical rejuvenation of the skin containing purified water, sodium tetraborate, lauramide diethanolamine, stearic acid, glycerine, collagen, papaya extract, retinyl palmitate, biotin, grapefruit seed extract, vitamin E acetate, ascorbic acid, linoleic acid, benzyl alcohol, and dehydroacetic acid. The moisturizer formulations of the invention are useful in the rejuvenation of the skin and in particular, after the skin has been exfoliated. The formulation may be retained in an air tight vessel such as an airless pump syringe. About 5 rads to about 10 rads of gamma radiation may be applied to the formulation retained within the air tight vessel.

Abstract: A liquid applicator comprising an absorbent member, and a single-piece, unitary body. The body can include a closed container defining a reservoir, and a tab. The container can include a main portion, a transition portion, a rib, and a chamber located in the tab and coupled to the transition portion via a frangible connection. The main portion, the transition portion, the rib, and the chamber can each define a portion of the reservoir, and at least the main portion, the transition portion, and the rib can have a uniform wall thickness. The tab can include the chamber and can be coupled to the transition portion at least by the frangible connection, the tab being movable with respect to the transition portion between a first position in which the frangible connection is intact and a second position in which the frangible connection is fractured.

Abstract: A method of manufacturing a needle-shaped body includes forming a needle-shaped body precursor such that the needle-shaped body precursor has a base portion and a needle-shaped portion on the base portion, and that the needle-shaped portion has a portion which contacts the base portion and has a form of a polygon, producing a needle-shaped body original plate by forming a curved surface portion in at least a portion of an apex portion of the polygon in a junction portion at a boundary between the base portion and the needle-shaped portion, producing a resin plate by transfer molding with the needle-shaped body original plate such that the resin plate has a concave pattern corresponding to the needle-shaped portion and the curved surface portion, and producing a needle-shaped body by transfer molding with the resin plate such that the needle-shaped body has a transferred needle-shaped portion and a transferred curved surface portion.

Abstract: A wireless power supply and voltage controller for powering and controlling a tattoo machine according to the present invention includes a battery housing having a plurality of walls that, collectively, define an interior area and a rechargeable battery positioned in the interior area of the battery housing. An input selection assembly is positioned on an exterior surface of a respective wall of the plurality of walls of the battery housing, the input selection assembly being operable to generate a speed generation signal. A controller is electrically connected to the input selection assembly that is operable to regulate a quantity of voltage flowing from the battery according to the speed generation signal.

Abstract: A catheter coupling has a tubing and two jaws extending in the longitudinal direction of the tubing which form a channel having an orifice to accommodate an end section of a catheter when the jaws abut against each other. The jaws are interconnected at a respective jaw end via a jaw joint having a joint axis extending transversely to the tubing. The other jaw end includes a snap-in locking member and a counter snap-in locking member, respectively, interacting therewith to form a snap-in locking arrangement. In the engagement position, the tubing is deformed by at least one jaw deformation component to securely accommodate the catheter. The coupling has at least one inspection window that allows a stop in the tubing for the end section of the catheter to be visually inspected to prevent an end section of the catheter from being introduced into the tubing if it is too short.

Abstract: A medical fluid control device for a medical fluid line system includes a fluid flow housing with at least one connection port for connecting to a further functional component of the fluid line system and which has an injection port with an openable closure element, and also having an adjustment member which is mounted movably in the fluid flow housing and which has flow channel sections which, depending on an adjustment position of the adjustment member, can be moved toward the at least one connection port and/or the injection port for a fluid throughflow. Assigned to at least one flow channel section of the adjustment member and/or to the injection port is at least one mechanical flow acceleration mechanism which assists with inside flushing of the injection port during a fluid throughflow.

Abstract: A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.

Abstract: Implantable devices and systems include one or more leads adapted to be emplaced in the internal thoracic vein (ITV) of a patient. The lead may include features to adapt the lead for such placement. An associated device for use with the lead may include operational circuitry adapted for use with a lead having an electrode for sensing and/or therapy purposes coupled thereto. Methods for implantation and use of such devices and systems are disclosed as well.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing, a first prong with a proximal end attached to the housing and a distal end extending away from the housing, and a first electrode on the first prong. The clip is configured to anchor the device to a muscle, a bone, and/or a tissue. The first prong is configured to contact a heart. The first electrode is configured to contact the heart. Sensing circuitry in the housing that is configured to sense an electrical signal from the heart, and therapeutic circuitry in the housing is in electrical communication with the first electrode and is configured to deliver electrical stimulation to the heart through the first electrode.

Abstract: A Wearable Cardiac Defibrillator (WCD) system is configured to be worn by a patient who carries a mobile communication device. The mobile communication device has a user interface that is configured to enable the patient to enter wireless inputs. The WCD system includes a communication module that is configured to establish a local comlink with the mobile communication device. The WCD system also includes a tethered action unit that has a user interface configured to enable the patient to enter action inputs. The WCD system can perform some of its functions in response to the action inputs or to the wireless inputs. Since the wireless inputs can be provided from the mobile communication device instead of the action unit, the patient is less likely to attract attention when entering them, and thus exhibit better compliance.

Abstract: A system and method is provided for simulating a wellness promoting, DC variable electric field in an environment. A DC power source (DC input) and converter provide a DC output and generate an electric field in between positive and negative electrodes in an environment. An electric field detector measures and transmits information (data) about the strength of the actual electric field in the environment. A microprocessor receives the data and compares the information to the parameters of a wellness promoting electric field in order to direct the function of a pulse width modulator to modulate the DC output and thereby the DC variable electric field in real-time. The wellness of a subject in the environment of the DC variable electric field is enhanced by ensuring the positive electrode is proximal to a positive part of the subject and the negative electrode is proximal to a negative part of the subject.

Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.

Abstract: A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudenal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.

Abstract: The present invention relates to an improved apparatus for self-administering audio-visual stimulation therapies comprising at least one horizontally-extending curved screen (11,11?) for delivering visual stimuli spatially distributed in an angular range substantially equal to the angular portion of extension of the screen (11,11?); at least one acoustic source (12, 12?) for delivering acoustic stimuli spatially distributed in an angular range at least in part coinciding with the angular range of spatial distribution of the visual stimuli, the at least one curved screen (11,11?) and the at least one acoustic source (12,12?) being connected to an electronic central processing unit (20) implementing at least activation means of the visual and/or acoustic stimuli; at least one signalling interface (21) able to be actuated by the patient to indicate the detection of at least one delivered stimulus connected to means for collecting data relative to the activation of the visual and/or acoustic stimuli and of the ac

Abstract: Systems and methods of reducing pain after surgery in the thoracic or abdominal region and managing chronic nerve pain in the thoracic or abdominal region are provided. Such methods involve an electrode assembly that has a proximal portion and a distal portion with the distal portion including a plurality of electrodes. At least one electrode of the plurality of electrodes is placed over each of a plurality of intercostal nerve bundles in the patient's body. The proximal portion of the electrode assembly is connected to a pulse generator. An electromagnetic field is applied to the plurality of intercostal nerve bundles. The plurality of electrodes is removed from the patient's body after an intercostal nerve block sufficient to alleviate the patient's pain has been achieved.

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region to address low back pain without creating unwanted sensory and/or motor side effects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

Abstract: Devices and methods provide for the sensing of physiological signals by providing a stimulation waveform that includes a stimulation pulse followed by an active recharge pulse to clear the charge in capacitors within the stimulation path. The active recharge pulse is followed by a period of passive recharge and then a period of no recharge. Non-neurological sources of artifacts within the sensed physiological signal may be handled by providing a brief period of passive recharge followed by a lengthy period of no recharge, which is made possible by the use of the active recharge pulse prior to the passive recharge. The period of no recharge removes any low impedance path to ground from the stimulation electrodes, which allows an amplifier of the sensing circuit to provide common mode rejection of non-neurological signals, such as cardiac signals, present at the sensing electrodes.

Abstract: An example of a system for applying neuromodulation to a patient includes a modulation output circuit and a modulation control circuit. The modulation output circuit may be configured to deliver dorsal horn stimulation. The modulation control circuit may be configured to control the delivery of the dorsal horn stimulation by executing a neuromodulation algorithm using modulation parameters. The modulation control circuit may include a response input and a parameter calibrator. The response input may be configured to receive response information indicative of one or more responses to the stimulation of the dorsal horn. The parameter calibrator may be configured to adjust one or more of the modulation parameters using the response information.

Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.

Abstract: An implantable neural stimulator method for modulating excitable tissue in a patient including: implanting a neural stimulator within the body of the patient such that one or more electrodes of the neural stimulator are positioned at a target site adjacent to or near excitable tissue; generating an input signal with a controller module located outside of, and spaced away from, the patient's body; transmitting the input signal to the neural stimulator through electrical radiative coupling; converting the input signal to electrical pulses within the neural stimulator; and applying the electrical pulses to the excitable tissue sufficient to modulate said excitable tissue.

Abstract: Various embodiments include methods for conducting cardiac resynchronization therapy and systems implementing the method. Various embodiments may include generating, using a processing unit, a three-dimensional (3D) activation map showing the propagation of electrical signals through a heart of a patient, identifying a stimulation point on the heart for cardiac resynchronization; generating real-time images of the heart, displaying, on a display unit, the stimulation point on the real-time images as a virtual stimulation point, implanting a pacing device into the patient at the identified stimulation point, such that the pace maker is aligned with the virtual stimulation point in the real-time images, and stimulating the heart using the pacing device.

Abstract: Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.

Abstract: A anchor for an implantable medical device includes an anchor body and a locking member. The anchor body includes a first trough extending along a first axis. The locking member is coupled to the anchor body and rotates with respect to a second axis, between an unlocked position and a locked position. The locking member includes protruding members that define a second trough aligned with the first trough when the locking member is rotated to the unlocked position, so as to form an open path for the implantable medical device to move through the first and second troughs. When the locking member is rotated to the locked position, the protruding members block at least a portion of the first trough to define a tortuous path between the first trough and the second trough so as to restrict a movement of the implantable medical device through the first and second troughs.