Abstract: An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end.

Abstract: A device measures blood glucose levels, temperature, heart rate, heart rate variability, respiration, SpO2, blood flow, blood pressure, total hemoglobin (SpHb), PVi, methemoglobin (SpMet), acoustic respiration rate (RRa), carboxyhemoglobin (SpCO), oxygen reserve index (ORi), oxygen content (SpOC) and/or EEG of a human

Abstract: In some implementations, an apparatus includes a physiological light monitoring subsystem that includes a source-detector assembly having a first side that has three transmitters of electromagnetic radiation frequencies in ranges of 375-415 nm, 640-680 nm and 920-960 nm frequencies and a first photodiode receiver of electromagnetic radiation in a 350-1100 nm range to measure an amount of electromagnetic radiation that is reflected by a subject, a microprocessor configured to determine an indication of an amount of glucose in the subject calculated from a ratio of electromagnetic radiation received by a first photodiode receiver of electromagnetic radiation in the 350-1100 nm range to measure an amount of electromagnetic radiation that is absorbed by the subject at the 375-415 nm frequency range in comparison to electromagnetic radiation received at the 920-960 nm frequency range, the subject being positioned between the first side and a second side.

Abstract: A remote photoplethysmography (RPPG) system includes an input interface to receive a sequence of measurements of intensities of different regions of a skin of a person indicative of vital signs of the person; a solver to solve an optimization problem to determine frequency coefficients of photoplethysmographic waveforms corresponding to the measured intensities at the different regions, wherein the solver determines the frequency coefficients to reduce a distance between intensities of the skin reconstructed from the frequency coefficients and the corresponding measured intensities of the skin while enforcing joint sparsity on the frequency coefficients; and an estimator to estimate the vital signs of the person from the determined frequency coefficients of photoplethysmographic waveforms.

Abstract: A system includes a minimally intrusive display system (MIDS) configured to be disposed on an eyewear. The MIDS includes a display system and a sensor system configured to provide for a sensor data. The MIDS further includes a processor configured to process the sensor data to derive a physiological measure. The processor is further configured to display, via the display system, the physiological measure, wherein the display system is disposed in the eyewear so that the physiological measure is only viewed when a user of the eyewear turns the user's pupil towards the display system at angle ? from a forward direction.

Abstract: The present invention relates to a system and methods generally aimed at surgery. More particularly, the present invention is directed at a system and related methods for performing surgical procedures and assessments involving the use of neurophysiology.

Abstract: A vector magnetocardiography method and a vector magnetocardiographic system carrying out the method. It is an object to provide an improved magnetocardiographic method, in particular in view of diagnosing ischemic heart disease. The method involves the calculation of the direction of an equivalent single current source ESCS or equivalent single magnetic source ESMS in relation to a reference direction which is independent of patient or heart position in order to compute a vector magnetocardiogram.

Abstract: A device for obtaining an electrical conductance reading from a patient includes a sensor head for contacting a patient's skin. The device includes a primary conductive tip positioned on the sensor head and an ancillary conductive tip positioned on the sensor head to contact a different portion of the patient's skin than the primary conductive tip. The primary conductive tip and the ancillary conductive tip are electrically isolated from each other. The primary conductive tip and the ancillary conductive tip are configured to contact a patient's skin when the sensor head is placed against the patient's skin to obtain independent measurements of electrical conductance.

Abstract: The invention relates to a heart rate monitor electrode (1). The electrode comprises a mounting (2), conductive points (23) and a plate of absorbent material (4). The free end (24) of at least some of the conductive points (23) is flush with the contact surface of the plate of absorbent material (4) or stands proud from same when the plate of absorbent material (4) is in at least partial compressed form and releases at least a portion of the liquid it contains. According to other aspects, the invention relates to a device comprising at least one such electrode (1) and a method for measuring heart rate by means of the same.

Abstract: The present disclosure provides systems and methods for detecting cardiac activations of a patient. A system includes a data acquisition system (DAQ) communicatively coupled to an activation detection module. The DAQ detects an electrogram generated at an electrode disposed on or in the patient. The activation detection module is configured to receive the electrogram from the DAQ and compute an activation response. The activation detection module is further configured to determine a set of candidate detection time points (CDTPs) in the activation response. The activation detection module is configured to compute respective deflection characteristics for each CDTP. The activation detection module is configured to identify a group of final detection time points (FDTPs) among the set of CDTPs for a metric corresponding to the respective deflection characteristics. The group of FDTPs has similar deflection characteristics.

Abstract: Methods, devices, systems, and apparatus, including computer programs encoded on a computer storage medium, for brain-controlled body movement assistance devices. In one aspect, a device includes a brain-controlled body movement assistance device with a brain-computer interface (BCI) component adapted to be mounted to a user, a body movement assistance component operably connected to the BCI component and adapted to be worn by the user, and a feedback mechanism provided in connection with at least one of the BCI component and the body movement assistance component, the feedback mechanism being configured to output information relating to a usage session of the brain-controlled body movement assistance device.

Abstract: A system and methods for automatically adjusting view angle when performing cardiac mapping and ablation are described herein. A three-dimensional (3D) map of a cardiac structure of a patient and a relative location (e.g., position and orientation) of a catheter within the cardiac structure may be displayed on a visual display device. According to an example procedure, the position and orientation of the tip of the catheter within the cardiac structure, and the current ablation target may be detected. A desired viewing angle of the ablation target may be known, determined, provided and/or learned through training sessions with the operator. The viewing angle of the 3D map of the cardiac structure may be automatically adjusted to correspond to the desired viewing angle using the known locations of the tip of the catheter and ablation target. Other details and procedures may be implemented, as described herein.

Abstract: The invention relates to methods, systems and computer program products for monitoring the biosignals of a test subject, in particular electrocardiograms, wherein a plurality of reference biosignals are recorded along with a respective assigned reference parameter value, a control biosignal is measured, a reference parameter value to be assigned to the control biosignal is determined and, on the basis of the reference parameter value assigned to the control biosignal and on the basis of the plurality of reference parameter values assigned to the plurality of reference biosignals, at least one comparative biosignal is selected from the plurality of stored reference biosignals for comparison, and wherein values of the reference parameter at least partially describe a physiological state of the test subject and/or general conditions of an environment.

Abstract: A system and method for detecting and verifying bradycardia/asystole episodes includes sensing an electrogram (EGM) signal. The EGM signal is compared to a primary threshold to sense events in the EGM signal, and at least one of a bradycardia or an asystole is detected based on the comparison. In response to detecting at least one of a bradycardia or an asystole, the EGM signal is compared to a secondary threshold to sense events under-sensed by the primary threshold. The validity of the bradycardia or the asystole is determined based on the detected under-sensed events.

Abstract: The present invention is intended to provide an EMG signal controller or a wheelchair using an EMG signal controller to allow full vehicular direct drive control, and wheelchair accessory control, by using one or more EMG sensors applied to certain muscles of a subject, and translating the movement of the muscles of the subject that the EMG sensors are connected, to electrical signals causing for the operation of a motorized wheelchair. The controller and wheelchair are designed specifically for paralyzed individuals with limited motion, but may be used by any subject with or without any physical or nervous system disabilities. The present invention further provides an emergency stop which is activated in the event that the subject using the wheelchair experiences a seizure or other neurological shock.

Abstract: A wireless sensor device includes a housing. A sensor is disposed in the housing and is constructed and arranged to obtain an analog electrical signal from a human patient. A processor circuit is disposed in the housing and is constructed and arranged to convert the analog electrical signal to a digitized electrical signal. A transmitter is disposed in the housing and is constructed and arranged to transmit, in a wireless manner, data relating to the digitized electrical signal. A power supply powers the device. The sensor is preferably an electrode or a respiratory sensor.

Abstract: Disclosed are devices, systems and methods for monitoring electrophysiological function from anatomical structures, including gastric slow-waves in high resolution electrogastrograms.

Abstract: An evoked potential monitoring system including a control unit having stimulator circuitry and a probe assembly coupled to the control unit. The probe assembly includes a stimulus probe and a stimulator handpiece selectively coupled to the stimulus probe. The handpiece includes a handle, control circuitry, and a switch. The control circuitry is electrically coupled to the stimulator circuitry. The switch is electrically coupled to the control circuitry and extends to an exterior portion of the handle. In this regard, movement of the switch remotely controls the stimulator circuitry to continuously increment or decrement a stimulation energy level delivered to the stimulus probe over a series of discrete, incremental steps.

Abstract: Methods are provided for administering a therapeutic agent directly to the brain parenchyma through a compromised region of the blood-brain barrier in a subject having a brain disorder, that involves first disrupting the blood-brain barrier (BBB) at an isolated region by locally administering an effective amount of a BBB opening agent in combination with a contrast agent at the region, followed by administering a therapeutically effective amount of a therapeutic agent. The step of disrupting the BBB is carried out with non-invasive MR (magnetic resonance) imaging to visualize for instance local parenchymal transcatheter perfusion at said isolated BBB region thereby indicating that the BBB region is compromised. The method of the invention allows for highly precise and safe drug delivery to the brain through blood-brain barrier disruption at specifically controlled regions without the need for skull opening and brain puncture or exposure of peripheral organs to high doses of therapeutic agents.

Abstract: A system and method for magnetic resonance imaging is provided. The method includes generating a main magnetic field through a region of interest (ROI), applying a slice selection gradient to an slice of the ROI, applying a plurality of RF pulses to the slice to generate a plurality of echoes, applying a first encoding gradient and a second encoding gradient on the echoes, and generating MR images based on the echoes.

Abstract: A health care system acquires data determines whether a patient is at risk of hypervolemia or hypovolemia. The method comprises (a) acquiring from a device memory a patient's absolute intrathoracic impedance data over a pre-specified time period, (b) determining a running average of the intrathoracic impedance data over the pre-specified time period, and (c) determining by the system whether the running average of the intrathoracic impedance data over the pre-specified time period exceeds one of a first and second range, the first range being a higher value boundary of intrathoracic electrical impedance and the second range being a lower value boundary of intrathoracic electrical impedance.

Abstract: A method includes, in a processor, receiving position signals that are indicative of positions of (i) multiple electrodes disposed on an inflatable balloon fitted at a distal end of a catheter, and (ii) first and second electrodes fitted on a shaft of the catheter, on either side of the balloon. The positions of the multiple electrodes disposed on the balloon are calculated based on the received position signals and based on a known distance between the first and second electrodes.

Abstract: According to some embodiments, methods and systems of enhancing a map of a targeted anatomical region comprise receiving mapping data from a plurality of mapping electrodes, receiving high-resolution mapping data from a high-resolution roving electrode configured to be moved to locations between the plurality of mapping electrodes, wherein the mapping system is configured to supplement, enhance or refine a map of the targeted anatomical region or to directly create a high-resolution three-dimensional map using the processor receiving the data obtained from the plurality of mapping electrodes and from the high-resolution roving electrode.

Abstract: The present disclosure includes support devices configured to be prevent breast deformation during an MRI imaging procedure. One embodiment of a support device comprises a foam insert shaped and sized to rest between a patient's breasts, generally upon the patient's sternum. The support device has a surface configured to engage an imaging modality component (i.e., coil of MRI machine) and prevent and/or minimize contact between the portion of the MRI coil and the pair of breasts when the support device is placed on the surface of the patient, which, in turn, reduces or eliminates any deformation of the breasts upon application of force from the MRI coil in a direction towards the breasts during an MRI imaging procedure.

Abstract: The present disclosure includes support devices configured to be prevent breast deformation during an MRI imaging procedure. One embodiment of a support device comprises a foam insert shaped and sized to rest between a patient's breasts, generally upon the patient's sternum. The support device has a surface configured to engage an imaging modality component (i.e., coil of MRI machine) and prevent and/or minimize contact between the portion of the MRI coil and the pair of breasts when the support device is placed on the surface of the patient, which, in turn, reduces or eliminates any deformation of the breasts upon application of force from the MRI coil in a direction towards the breasts during an MRI imaging procedure.

Abstract: An apparatus for the control of a medical implant in a mammal body is provided. The apparatus comprises a first and a second part being adapted to be in electrical connection with each other by using said body as a conductor, in which apparatus the first part is adapted for implantation in the mammal body for the control of and communication with the medical implant, the second part is adapted to be worn on the outside of the mammal body in physical contact with said body and adapted to receive control commands from a user and to transmit these commands to the first part. The apparatus is adapted for communication between the first and the second parts and in that the second part is adapted to receive and recognize the control commands from a user transmitted to the first part for the control of said implant, the first part being adapted to convey such signals to the implant.

Abstract: A biological sound analyzing apparatus is provided with: an obtaining device configured to obtain first information regarding biological sounds in a first period; and an outputting device configured to output second information, which indicates a ratio of a generation time in which sounds indicating abnormality of a living body and included in the biological sounds are generated, with respect to the first period, on the basis of the first information. According to the biological sound analyzing apparatus, it is possible to preferably analyze information regarding the sounds indicating the abnormality because it can output the ratio of the generation time of the sounds indicating the abnormality and included in the biological sounds.

Abstract: Various systems and devices are disclosed for measuring an analyte, such as acetone, in a breath sample of a human subject. In some embodiments, a system is provided that includes a displosable cartridge having a reaction chamber containing an interactant, such as interactant particles. The interactant reacts with an analyte in a breath sample that is passed along a flow path through the reaction chamber. An optical subsystem measures a color change resulting from a reaction in the reaction chamber; this color change is indicative of a concentration of the analyte in the breath sample. In some embodiments, the optical subsystem illuminates the cartridge using multiple LEDs of different colors or wavelengths.

Abstract: Disclosed embodiments describe techniques for body part motion analysis using kinematics. Two or more sensors, which include stretch sensors or inertial sensors, are attached to a body part of an individual. The two or more sensors enable collection of motion data of the body part. Data is collected from the two or more sensors, where the two or more sensors provide electrical information based on a micro-expression of movement of the body part. One or more processors are used for analyzing the electrical information from the two or more sensors to generate a kinematic phase pattern. The kinematic phase pattern is rendered as part of a kinematic sequence, where the rendering is displayed visually. The rendering includes an animation and enables additional kinematic analysis. The two or more sensors capture two or more modalities of body part motion.

Abstract: Embodiments of the present disclosure include a handheld multi-parameter patient monitor capable of determining multiple physiological parameters from the output of a light sensitive detector capable of detecting light attenuated by body tissue. For example, in an embodiment, the monitor is capable of advantageously and accurately displaying one or more of pulse rate, plethysmograph data, perfusion quality, signal confidence, and values of blood constituents in body tissue, including for example, arterial carbon monoxide saturation (“HbCO”), methemoglobin saturation (“HbMet”), total hemoglobin (“Hbt”), arterial oxygen saturation (“SpO2”), fractional arterial oxygen saturation (“SpaO2”), or the like. In an embodiment, the monitor displays a line associated with a patient wellness level.

Abstract: A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Abstract: A sensor device, such as a biosensor, may comprise a polymer substrate, which is structured so as to form sets of microneedles and respective vias. The microneedles extend, each, from a base surface of the substrate. Each of the vias extends through a thickness of the substrate, thereby forming a corresponding set of apertures on the base surface. Each of the apertures is adjacent to a respective one of the microneedles. The device further may comprise two or more electrodes, these including a sensing electrode and a reference electrode. Each electrode may comprise an electrically conductive material layer that coats a region of the substrate, so as to coat at least some of the microneedles and neighboring portions of said base surface. Related devices, apparatuses, and methods of fabrication and use of such devices may be provided.

Abstract: An apparatus comprising a pump, an input configured to receive information related to a user, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a timing module configured to initiate delivery of a drug in time and to adjust delivery according to the received information. Other devices, systems, and methods are disclosed.

Abstract: The present invention relates generally to systems and methods for processing, transmitting, and displaying data received from continuous analyte sensor, such as a glucose sensor. In some embodiments, the continuous analyte sensor system comprises a sensor electronics module that includes power saving features. One feature includes a low power measurement circuit that can be switched between a measurement mode and a low power mode, in which charging circuitry continues to apply power to electrodes of a sensor during the low power mode. In addition, the sensor electronics module can be switched between in a low power storage mode higher power operational mode via a switch. The switch can include a reed switch or optical switch, for example. A validation routine can also be implemented to ensure an interrupt signal sent from the switch is valid.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Abstract: A biological information detection apparatus for measuring a SpO2 without contact from a distant position includes a camera that acquires an image with visible and infrared light, a first wavelength fluctuation detection section detects a temporal variation of a wavelength of an image with the visible light to generate a first wavelength difference data signal, a first amplitude detection section detects an amplitude of the first wavelength difference data signal, a second wavelength fluctuation detection section detects a temporal variation of a wavelength of an image with the infrared light to generate a second wavelength difference data signal, a second amplitude detection section detects an amplitude of the second wavelength difference data signal, a ratio calculation section calculates a ratio between the amplitudes of the first and second wavelength difference data signals, and an oxygen saturation concentration calculation section calculates an oxygen saturation concentration based on the calculated am

Abstract: A non-invasive, optical-based physiological monitoring system is disclosed. One embodiment includes an emitter configured to emit light. A diffuser is configured to receive and spread the emitted light, and to emit the spread light at a tissue measurement site. The system further includes a concentrator configured to receive the spread light after it has been attenuated by or reflected from the tissue measurement site. The concentrator is also configured to collect and concentrate the received light and to emit the concentrated light to a detector. The detector is configured to detect the concentrated light and to transmit a signal representative of the detected light. A processor is configured to receive the transmitted signal and to determine a physiological parameter, such as, for example, arterial oxygen saturation, in the tissue measurement site.

Abstract: Systems and method are disclosed for determining a concentration of an analyte in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A particular component of the fluid (e.g., plasma) may be separated and/or positioned such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a sample container that has two window pieces. The system can have a fluid passage having a tip configured to mate with a multi-lumen catheter without leaking. The multi-lumen catheter can have proximal and distal ports. A fluid pressure system can be configured to periodically draw fluid from vasculature through a proximal intravascular opening and the proximal port while maintaining a low pressure and/or flow rate to thereby reduce risk of reversing the fluid flow in a vessel and drawing infusates upstream into another intravascular opening.

Abstract: Provided are a packaging container, a blood test kit, and a blood analysis method, by which sealability of a collected liquid specimen is made to be compatible with easiness of extraction.

Abstract: A collection fitting, system, and method for sampling fluid from a tissue site is described. The collection fitting includes a switch fitting having a first passage and a second passage. The collection fitting also includes a bypass switch coupled to the switch fitting. The bypass switch is operable to fluidly couple the first passage and the second passage through the bypass switch. The bypass switch is also operable to fluidly couple the first passage and the second passage through a specimen container.

Abstract: The present invention relates to a system and method for assessing and training the quality of attentional awareness and control of an individual. The individual's attention is monitored using a neurophysiological system such as EEG while using a computer system and display that provides signals that allow the correlation of behavioral measures of attention with neurophysiological measures. The combination of those signals is a novel, accurate and reliable system for assessing any individual's true attention capabilities.

Abstract: A method performed by a computer correlates vesicoelastic pressure data (10, 12, 14) with volume data and calculates vesicoelastic work performed by the bladder (20), wherein the amount of vesicoelastic work performed by the bladder (20) is determined by calculating an area under said vesicoelastic pressure data (10, 12, 14) when said vesicoelastic pressure data (10, 12, 14) is correlated against the volume data.

Abstract: Disclosed is a device for diagnosing and treating pelvic organ prolapse, including a measurement stick configured to protrude into a vagina, a distance measuring mechanism for measuring the distance from an end portion of a protruding end of the measurement stick to a hymen edge of the vagina, and an assessment mechanism. The distance measuring mechanism is connected with the assessment mechanism. The assessment mechanism includes buttons, a memory, a CPU and a display which are connected with the CPU, respectively. The device for diagnosing and treating pelvic organ prolapse provided by the present disclosure can be used in a rapid, convenient and accurate manner, which not only saves a great amount of medical resources, but also alleviates the pain index of patients during diagnosis and treatment.

Abstract: A dermatoscope which can focus at a certain depth, e.g. below the top surface of the skin. Light sources are provided for creating shadows of a skin lesion and an image acquisition device to take images from which a 3D reconstruction can be made.

Abstract: Disclosed are hair analysis systems and methods comprising: (a) a step to capture an image of a user at an image capture unit and to send the image from the image capture unit to a hair analysis unit; (b) a step to analyze the user's hair condition at hair analysis unit, based on the image from the image capture unit by using a deep neural network, and to provide an analysis result to a display unit; and (c) a step to display at a display unit the analysis result to the user. The present invention provides the system and the method with an improved sensitivity.

Abstract: A method is described for determining a degree of damage to hair, which includes: registering light which is radiated by the hair sample while a hair sample is illuminated with light; based on the registered light, determining first regions of the hair sample which reflect the light with higher interference, and second regions of the hair sample which reflect the light with lower interference; and determining a degree of damage to the hair sample based on the extents of the first regions and of the second regions.

Abstract: The present application relates to a posture display method, a device and a system for a guiding channel, and readable storage medium. The posture display method of a guiding channel includes determining an original position relation between a three-dimensional affected limb image and a virtual guiding channel displayed in a monitor according to an original position relation between the guiding channel and an affected limb and obtaining posture change data of the guiding channel. The method further includes adjusting the posture of the virtual guiding channel based on the posture change data, so as to the relative position relation between the virtual guiding channel and the three-dimensional affected limb image matches with the relative position relation between the guiding channel and the affected limb.

Abstract: Systems, devices, and methods are provided for reducing a risk of unintentional falls in a subject that is at risk for falls. The device includes a sensor and a stimulator. The sensor is configured to be positioned adjacent a body portion of the user that changes orientation when the user sits and stands. The sensor is also configured to emit an activation signal when the user stands and to emit a deactivation signal when the user sits or lies down. The stimulator is in communication with the sensor and is configured to be positioned adjacent one of a calf and a lower back of the user. The stimulator is configured to vibrate at a frequency that stimulates proprioceptors of the user without inducing muscle contractions upon receipt of the activation signal from the sensor and to cease vibration upon receipt of the deactivation signal from the sensor.