Patents Issued in November 28, 2019
  • POLIOVACCINE
    Publication number: 20190358315
    Abstract: The invention provides poliovirus like particles, which comprise stabilised empty poliovirus capsids that retain their native antigenic properties. The invention also provides methods of identifying mutations useful in the production of such poliovirus like particles, methods of producing such poliovirus like particles and the use of such poliovirus like particles in methods of vaccinating against poliovirus.
    Type: Application
    Filed: January 17, 2018
    Publication date: November 28, 2019
    Inventor: Andrew Macadam
  • INFECTIOUS BRONCHITIS VIRUS VACCINE USING NEWCASTLE DISEASE VIRAL VECTOR
    Publication number: 20190358316
    Abstract: Provided are compositions and methods that involve recombinant Newcastle disease viruses (rNDVs) that contain an S protein of infectious bronchitis virus (IBV). The rNDV particles include a contiguous segment of IBV S protein that spans an IBV cleavage site between IBV SI and IBV S2 proteins, and can include a full length IBV S protein. Because the particles are multivalent they also stimulate a protective immune response against NDV infection. The compositions are particularly useful for use with avian animals, such as chickens. Isolated rNDV particles, and vaccine compositions that contain them are also provided.
    Type: Application
    Filed: February 6, 2018
    Publication date: November 28, 2019
    Inventors: Siba K. SAMAL, Edris SHIRVANI
  • Cytomegalovirus Surface Protein Complex for use in Vaccines and as a Drug Target
    Publication number: 20190358317
    Abstract: Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV protein complex comprising pUL128 or pUL130, and nucleic acid vaccines comprising at least one nucleic acid encoding a CMV protein complex comprising pUL128 or pUL130 are described. Also disclosed are therapeutic antibodies reactive against a CMV protein complex comprising pUL128 or pUL130, as well as methods for screening compounds that inhibit CMV infection of epithelial and endothelial cells, methods for immunizing a subject against CMV infection, methods for determining the capability of neutralizing antibodies to inhibit CMV infection of cell types other than fibroblasts, and methods of diminishing an CMV infection.
    Type: Application
    Filed: April 11, 2019
    Publication date: November 28, 2019
    Inventors: Thomas Shenk, Dai Wang
  • IMPROVED VACCINE COMPOSITIONS AND METHODS OF USE
    Publication number: 20190358318
    Abstract: The present disclosure provides vaccine compositions comprising at least one adjuvant and at least one antigen, wherein the adjuvant is a cationic lipid. The disclosure also provides methods of treating a disease in a mammal, methods of preventing a disease in a mammal, and methods of effecting antigen cross presentation to induce a humoral immune response and a cellular immune response in a mammal utilizing the vaccine compositions. Cross presentation of various antigens can be achieved by formulating the specific antigens with cationic lipids possessing adjuvant properties.
    Type: Application
    Filed: April 18, 2019
    Publication date: November 28, 2019
    Inventors: Frank Bedu-Addo, Eric Jacobson, Kenya Johnson
  • LIPIDS AS SYNTHETIC VECTORS TO ENHANCE ANTIGEN PROCESSING AND PRESENTATION EX-VIVO IN DENDRITIC CELL THERAPY
    Publication number: 20190358319
    Abstract: The invention covers the use of certain classes of lipids including cationic lipids in ex-vivo dendritic cell therapies. The cationic lipids enhance antigen uptake, processing and presentation of the processed antigens by dendritic cells to CD8+and CD4+T-cells via the MHC classes I and II presentation pathways respectively. Antigen uptake via cationic lipid by dendritic cells result in significant lowering of the population of the immune suppressive regulatory T cells in the tumors and a significant increase of the tumor targeting cytotoxic T-cells. Loss of regulatory T cells and increase of tumor specific cytotoxic cells are conducive to effective elimination of the tumors.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Frank Bedu-Addo, Greg Conn, Siva K. Gandhapudi, Martin Ward, Jerold Woodward
  • METHODS AND COMPOSITIONS FOR INHIBITION OF EGF/EGFR PATHWAY IN COMBINATION WITH TYROSINE KINASE INHIBITORS
    Publication number: 20190358320
    Abstract: A method of treating patients suffering from cancers driven by deregulated Human Epidermal Growth Factor Receptor (HER1/Human EGFR) comprising administering to a patient in need of such treatment a flexible and active regimen for combining a tyrosine kinase inhibitor (TKI) and anti-EGF antibodies for inhibition of the pathway activated by EGF-EGFR binding (mAb). The anti-EGF antibodies can be produced by active immunization or provided passively by the administration of antibodies that are anti-EGF. The method comprises TKI administered according to a continuous regimen based on an average daily dose in the range of 10 to 150 mg and the mAb is co-administered either actively or passively according to a dosing regimen achieving a therapeutic effective amount repeated thrice, twice or once a week, once in two weeks, once in three weeks or at least once monthly.
    Type: Application
    Filed: March 18, 2019
    Publication date: November 28, 2019
    Inventors: Erik D'Hondt, Miguel Ángel Molina Vila
  • USE OF SEMAPHORIN-4D BINDING MOLECULES FOR MODULATION OF BLOOD BRAIN BARRIER PERMEABILITY
    Publication number: 20190358321
    Abstract: Provided herein are methods for decreasing blood-brain barrier permeability in a subject with a neuroinflammatory disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its high affinity Plexin-B1 receptor.
    Type: Application
    Filed: June 6, 2019
    Publication date: November 28, 2019
    Inventors: Ernest S. Smith, Maurice Zauderer
  • PROTEIN FORMULATIONS AND METHODS OF MAKING SAME
    Publication number: 20190358322
    Abstract: The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a high protein formulation and/or may have low levels of conductity resulting from the low levels of ionic excipients. Also included in the invention are formulations comprising water and proteins having low osmolality.
    Type: Application
    Filed: December 20, 2018
    Publication date: November 28, 2019
    Inventors: Wolfgang Fraunhofer, Annika Bartl, Hans-Juergen Krause, Markus Tschoepe, Katharina Kaleta
  • HIGH CONCENTRATION ANTIBODY AND PROTEIN FORMULATIONS
    Publication number: 20190358323
    Abstract: The present application relates to highly concentrated antibody and protein formulations with, reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and method for using them to treat disorders treatable by the formulated antibody or protein.
    Type: Application
    Filed: February 7, 2019
    Publication date: November 28, 2019
    Inventors: Jun LIU, Steven J. SHIRE
  • PHARMACEUTICAL PREPARATION STABLY COMPRISING CD147 MONOCLONAL ANTIBODY
    Publication number: 20190358324
    Abstract: Disclosed is a pharmaceutical preparation comprising a CD147 monoclonal antibody, a buffer, a protein protectant and a surfactant. The pharmaceutical preparation can maintain the stability of the CD147 monoclonal antibody over a long period of time. Also disclosed are the use of the pharmaceutical preparation in the preparation of a drug for treating CD147-related diseases, in particular non-small cell lung cancer, and a method for preparing the pharmaceutical preparation.
    Type: Application
    Filed: December 27, 2017
    Publication date: November 28, 2019
    Inventor: Xiaochun CHEN
  • METHOD FOR THE TREATMENT OR PREVENTION OF INFECTION-RELATED IMMUNE CONDITIONS USING A COMPOSITION COMPRISING IGM
    Publication number: 20190358325
    Abstract: Embodiments of the present invention provide methods for the treatment or prevention of infection-related immune conditions using compositions comprising IgM.
    Type: Application
    Filed: June 28, 2019
    Publication date: November 28, 2019
    Applicant: GRIFOLS WORLDWIDE OPERATIONS LIMITED
    Inventors: Thomas BARNETT, David A. ROSS
  • COMPOSITIONS AND METHODS FOR TREATMENT OF ENTEROVIRUS INFECTION
    Publication number: 20190358326
    Abstract: Enteroviruses, such as EV-A71, have been found to utilize hWARS as a cell surface receptor, with expression ofhWARS rendering cells susceptible to enteroviral infection. Reduction in hWARS cell surface activity reduces susceptibility to enteroviral infection and provides a mode for treatment or prevention of enteroviral infection and its sequelae. Similarly, expression of hWARS in cultured cells and animal models provides models for understanding enteroviral disease mechanisms and the development of vaccines and/or pharmaceuticals for preventing or treating enteroviral disease.
    Type: Application
    Filed: September 13, 2017
    Publication date: November 28, 2019
    Inventors: Philip Man Lung YEUNG, Fuk Woo Jasper CHAN, Manson FOK, Johnson Yiu-Nam LAU, Kwok-Yung YUEN
  • BIOPHOTONIC COMPOSITIONS COMPRISING LICHEN EXTRACT AND THEIR USE TO TREAT SKIN DISORDERS
    Publication number: 20190358327
    Abstract: The present disclosure provides biophotonic compositions comprising a lichen extract and a carrier medium and methods and uses thereof.
    Type: Application
    Filed: December 22, 2017
    Publication date: November 28, 2019
    Inventors: David OHAYON, Paschalis PASCHALAKIS, Remigio PIERGALLINI, Nikolaos LOUPIS
  • STABLE PHARMACEUTICAL FORMULATIONS OF METHYLNALTREXONE
    Publication number: 20190358328
    Abstract: Stable pharmaceutical compositions useful for administering methylnaltrexone are described, as are methods for making the same. Kits, including these pharmaceutical compositions, also are provided.
    Type: Application
    Filed: June 13, 2019
    Publication date: November 28, 2019
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Suketu P. Sanghvi, Thomas A. Boyd
  • STABILIZED EFINACONAZOLE FORMULATIONS
    Publication number: 20190358329
    Abstract: The present invention provides compositions containing efinaconazole, butylated hydroxytoluene, a salt of ethylenediaminetetraacetic acid, and optional citric acid. The compositions exhibit stable color profiles and are useful in the treatment of fungal infections.
    Type: Application
    Filed: June 7, 2019
    Publication date: November 28, 2019
    Inventors: Varsha Bhatt, Nayan Desai, Radhakrishnan Pillai
  • CLINICAL FORMULATIONS
    Publication number: 20190358330
    Abstract: Some aspects of this disclosure provide clinical media that support viability, re-plating efficiency, and repopulation capacity of cells and tissues during storage for up to 48 hours or longer. The clinical media provided herein are also useful for clinical irrigation. Cell or tissue preparations comprising a cell population or tissue and a clinical medium as provided herein are also provided, as are methods for generating such preparations. Methods for using the clinical media and cell and tissue preparations provided herein, for example, for administering an effective amount of cells or tissue to a subject in need thereof, are also disclosed.
    Type: Application
    Filed: August 18, 2016
    Publication date: November 28, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Roger Gay, Judson Ratliff, Romma E. Southwick
  • DRUG SUSTAINED-RELEASE CARRIER AND METHOD FOR PRODUCING SAME
    Publication number: 20190358331
    Abstract: A DDS carrier enabling sustained release of a drug and a production method therefor. Wherein, the drug is retained by a PEG-carboxy group-containing polymer graft. Among polymers, a carboxy group-containing polysaccharide can be suitably used. The PEG-carboxy group-containing polymer graft is a compound prepared by grafting PEG into the carboxy group-containing polysaccharide. When the carboxy group-containing polysaccharide is used, it can be produced by utilizing a condensation reaction of an aminated PEG and a carboxy group-containing polysaccharide in coexistence with a triazine-based condensing agent. Alternatively, the PEG-carboxy group-containing polysaccharide graft can be produced by utilizing a condensation reaction of PEG and a carboxy group-containing polysaccharide in coexistence with an acid.
    Type: Application
    Filed: August 9, 2019
    Publication date: November 28, 2019
    Inventors: Ying-shu Quan, Tooru Ooya, Rongrong Jiang, Fumio Kamiyama
  • ORAL PRODUCT WITH ALGINATE COMPOSITION OF RELEASABLE SUBSTANCE
    Publication number: 20190358332
    Abstract: The disclosure relates to a plant fiber product for oral use, the product containing a mixture of at least: plant fibers; and at least one added substance intended to be released from the product when the product is used. The product contains an alginate composition, dispersed in the product and comprising at least water, alginate and the added substance, the composition containing an alginate matrix that firmly retains at least a major proportion of the added substance so long as the matrix is intact, and the alginate matrix being formed so as to disintegrate and/or dissolve in the chemical and physical environment that exists in a user's mouth. The disclosure also relates to a method for preparing such a plant fiber product.
    Type: Application
    Filed: August 12, 2019
    Publication date: November 28, 2019
    Inventor: Lars Bjoerkholm
  • ENDOCYTOSIS ENHANCER FOR DRUG DELIVERY SYSTEM
    Publication number: 20190358333
    Abstract: The present invention addresses the problem of providing an endocytosis enhancer comprising associates formed from a fluorescent protein. The fluorescent protein is preferably any one selected from the group consisting of a white fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein and a green fluorescent protein. The endocytosis enhancer according to the present invention can enhance the cellular uptake of a drug, which is encapsulated in micelles each formed from a fluorescent-protein-supported carbosilane dendrimer, through endocytosis.
    Type: Application
    Filed: August 7, 2019
    Publication date: November 28, 2019
    Inventors: Miho Suzuki, Ken Hatano, Shojiro Yoshida, Yasuhiro Yamashita
  • METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF NEURODEGENERATION
    Publication number: 20190358334
    Abstract: The present invention provides pharmaceutical compositions comprising a metal-desferrioxamine B complex or a combination thereof, for preventing, inhibiting, reducing or ameliorating neurodegeneration, thereby treating diseases, disorders, or conditions characterized by or associated with neurodegeneration; as well as methods of use.
    Type: Application
    Filed: February 8, 2017
    Publication date: November 28, 2019
    Inventors: Mordechai CHEVION, Vladimir VINOKUR, Eduard BERENSHTEIN
  • STOMACH ACID-STABLE AND MUCIN-BINDING PROTEIN-POLYMER CONJUGATES
    Publication number: 20190358335
    Abstract: Provided herein are protein-polymer conjugates, pharmaceutical compositions including protein-polymer conjugates, and methods of using the same, e.g., in therapeutic and industrial applications.
    Type: Application
    Filed: January 12, 2018
    Publication date: November 28, 2019
    Inventor: Alan J. RUSSELL
  • CELL INTERNALIZING COMPOUNDS
    Publication number: 20190358336
    Abstract: Provided herein are cell penetrating compounds having the Formula I: where, generally, each T is a thiol reactive group (e.g., a phosphorothioate), each L is a linker (e.g., a linear alkyl), and Y is a biologic (e.g., an antibody). Also provided are pharmaceutical compositions including the cell penetrating compounds, and methods of delivering the compound into a cell.
    Type: Application
    Filed: June 27, 2019
    Publication date: November 28, 2019
    Applicant: Sorrento Therapeutics, Inc.
    Inventors: Yanwen Fu, Gunnar F. Kaufmann, Heehyoung Lee, Tong Zhu, Henry Hongjun Ji
  • NEW PEPTIDE-LINKED ESTER PRODRUGS ACTIVATED BY PROSTATE-SPECIFIC ANTIGEN
    Publication number: 20190358337
    Abstract: The present disclosure is directed to a series of target-selective chemotherapeutic ester prodrugs comprising PSA-cleavable peptides that promote the delivery of free doxorubicin and other chemotherapeutic agents into the prostate and/or prostate tumors with greater efficiency.
    Type: Application
    Filed: February 2, 2018
    Publication date: November 28, 2019
    Inventors: Longqin HU, Herve ALOYSIUS
  • IMPROVED HYBRID TELODENDRIMERS
    Publication number: 20190358338
    Abstract: Methods and compositions are provided for hybrid telodendrimers and nanocarriers containing such hybrid telodendrimers.
    Type: Application
    Filed: September 15, 2017
    Publication date: November 28, 2019
    Inventors: Kit S. LAM, Yuanpei LI, Guarav BHARADWAJ
  • ANTIPROLIFERATIVE COMPOUNDS AND CONJUGATES MADE THEREFROM
    Publication number: 20190358339
    Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Ivar M. McDonald, Prasanna Sivaprakasam, Christiana I. Iwuagwu, Kevin M. Peese, Heng Cheng, Naidu S. Chowdari, Sanjeev Gangwar
  • TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES
    Publication number: 20190358340
    Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.
    Type: Application
    Filed: August 8, 2019
    Publication date: November 28, 2019
    Inventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin
  • BIOCOMPATIBLE AND HYDROPHILIC POLYMER CONJUGATE FOR TARGETED DELIVERY OF AN AGENT
    Publication number: 20190358341
    Abstract: The present invention provides a biocompatible and hydrophilic polymer conjugate comprising a linear, aliphatic copolymer backbone to which is conjugated a binding moiety and an agent. The binding moiety is conjugated to an end of the copolymer backbone and facilitates targeted delivery of the agent. Also provided are methods for preparing such polymer conjugates via free radical polymerisation techniques such as reversible addition fragmentation chain transfer (RAFT) polymerisation and uses of such polymer conjugates in diagnosis or therapy.
    Type: Application
    Filed: December 22, 2017
    Publication date: November 28, 2019
    Inventors: Timothy ADAMS, John CHIEFARI, Xiaojuan HAO, Fei HUANG, Laurence MEAGHER, Judith SCOBLE, Charlotte WILLIAMS
  • PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES
    Publication number: 20190358342
    Abstract: A conjugate of formula (I): Ab-(DL)p wherein: Ab is an antibody, or an active fragment of an antibody; DL is (II).
    Type: Application
    Filed: February 8, 2018
    Publication date: November 28, 2019
    Inventor: Patricius Hendrikus Cornelis VAN BERKEL
  • ADOPTIVE TRANSFER OF CAR T CELLS WITH SURFACE-CONJUGATED DRUG-LOADED NANOPARTICLES AND USES THEREOF
    Publication number: 20190358343
    Abstract: Described herein are compositions including an immune effector cells that are chemically modified at the surface with one or more active agent-loaded nano- or micro-particles for controlled release of the active agent. Exemplary drug-loaded nanoparticles include crosslinked multilayer liposome (CMLV) encapsulating an A2a receptor inhibitor. The modified immune effector cells may also present one or more chimeric antigen receptors (CARs) on the surface. Also provided are methods of using the same to treat cancer.
    Type: Application
    Filed: March 20, 2018
    Publication date: November 28, 2019
    Applicant: University of Southern California
    Inventors: Pin Wang, Yu Jeong Kim, Natnaree Siriwon
  • MINERAL COATED MICROPARTICLES FOR SUSTAINED DELIVERY OF STEROIDS
    Publication number: 20190358344
    Abstract: Disclosed are formulations for providing a steroid. Formulations include a mineral coated microparticles wherein a steroid is adsorbed to the mineral coating or incorporated within the mineral coating. Also disclosed are methods for sustained delivery of a steroid and methods for treating inflammation or pain using a formulation for providing sustained delivery of a steroid.
    Type: Application
    Filed: May 22, 2019
    Publication date: November 28, 2019
    Inventors: Anna Clements, William L. Murphy, Barry Kurokawa
  • AMPHIPHILIC NONSTEROID ANTI-INFLAMMATORY PLATINUM NANOPARTICLES AND PREPARATION METHODS THEREFOR
    Publication number: 20190358345
    Abstract: The present invention discloses amphiphilic nonsteroid anti-inflammatory platinum nanoparticles, preparation methods therefor and applications thereof. The amphiphilic nonsteroid anti-inflammatory platinum nanoparticle includes an amphiphilic complex formed by coordinating a nonsteroid anti-inflammatory drug and a platinum antitumor drug. Compared with other platinum drugs, the amphiphilic nonsteroid anti-inflammatory platinum prepared according to the present invention can self-assemble into a nanoparticle in an aqueous solution without the addition of an additive or a surfactant. The amphiphilic platinum complex can achieve targeted accumulation of tumor tissues by means of the enhanced permeability and retention effect of the tumor tissues, thereby reducing the side effects of platinum drugs.
    Type: Application
    Filed: September 4, 2017
    Publication date: November 28, 2019
    Applicant: CHINA PHARMACEUTICAL UNIVERSITY
    Inventors: Hulin JIANG, Lei XING, Chenxi YANG
  • AAV-MEDIATED DELIVERY OF ATP1A3 GENES TO CENTRAL NERVOUS SYSTEM
    Publication number: 20190358346
    Abstract: This invention relates to a transgenic vector for transducing cells of a mammal's CNS and transgenically expressing a protein in the mammal's CNS. The transgenic vector comprises a virus-derived vector, a nucleic acid sequence encoding the protein, and an endogenous ATP1A3 promoter sequence. This invention also relates to a composition comprising a recombinant AAV vector comprising a nucleic acid sequence encoding a ATP1A3 protein, in a form compatible with administration into the CNS. The invention also relates to a method for treating a subject having a neurological disorder associated with mutations in the ATP1A3 gene and a method for delivering a transgenic ATP1A3 DNA to the central nervous system of a mammal by administering the recombinant AAV vector into the mammal's CNS.
    Type: Application
    Filed: April 9, 2019
    Publication date: November 28, 2019
    Inventors: Simon Frost, Natalia Morsci, Neil Hackett, Dolan Sondhi
  • METHODS AND COMPOSITIONS FOR EFFICIENT GENE DELETION
    Publication number: 20190358347
    Abstract: Provided herein are gene-editing methods and compositions for improving the efficiency of deleting segments of DNA from cells, cells that are genetically modified using the disclosed methods and compositions, and methods of treatment using the genetically modified cells.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 28, 2019
    Inventors: ELIZABETH PAIK, MAURICIO CORTES
  • CHARACTERIZATION OF BIOLOGICAL TISSUES AT A CELLULAR LEVEL USING RED AND FAR-RED FLUORESCENT DYES
    Publication number: 20190358348
    Abstract: A method for observing the morphology of a biological tissue is disclosed. The method involves administering a combination of fluorescent dyes into the biological tissue. The combination of fluorescent dyes includes two or more fluorescent dyes selected from a group consisting of: patent blue V, isosulfan blue, toluidine blue, hypericin, indocyanine green, MVAC, and doxorubicin. The method further involves using a microscopic imaging system to form an image of the biological tissue. The microscopic imaging system forms the image based on a contrast resulting from the combination of fluorescent dyes. A concentration of the first fluorescent dye depends on an administration route. A fluorescence of the combination of fluorescence dyes reveals the morphology of the biological tissue at a cellular scale. The fluorescence is observed by means of one of: ex vivo microscopy and in vivo microscopy.
    Type: Application
    Filed: June 14, 2019
    Publication date: November 28, 2019
    Applicants: IGR-Institut Gustave Roussy, Mauna Kea Technologies
    Inventors: Muriel Abbaci, Odile Casiraghi, Corinne Laplace-Builhe
  • METHODS FOR EVALUATION OF TREATMENT AND PROGRESSION OF NEUROLOGICAL DISORDERS
    Publication number: 20190358349
    Abstract: Provided herein are methods related to the evaluation of treatment efficacy for neurological disorders. Also provided are methods for evaluating the progression of neurological disorders.
    Type: Application
    Filed: May 23, 2019
    Publication date: November 28, 2019
    Inventor: Carrolee BARLOW
  • METHODS AND COMPOSITIONS FOR NEAR INFRARED FLUORESCENT NANODOTS WITH AGGREGATION-INDUCED EMISSION CHARACTERISTICS
    Publication number: 20190358350
    Abstract: Disclosed herein is a donor-acceptor-donor (D-A-D) compound of formula I, where in the acceptors are mono-substituted tetraphenylethylene moieties. Also disclosed herein are fluorescent nanodots that comprise the compound of formula (I) and uses of said compound or nanodots in in vivo imaging or detecting of cancer cells in a subject.
    Type: Application
    Filed: August 10, 2017
    Publication date: November 28, 2019
    Inventors: Bin LIU, Jie LIU
  • 177-LU LABELED ACTIVE SITE INHIBITED FACTOR VII
    Publication number: 20190358351
    Abstract: There is provided a 177-Lu labelled peptide for site-specific targeting of TF thereby enabling treatment of a cancer disease associated with high TF expression; e.g. treatment of cancer by administering to a patient an effective amount of the 177-Lu labelled peptide.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 28, 2019
    Inventors: Andreas KJAER, Carsten HAAGEN NIELSEN
  • ACOUSTICALLY EXCITED ENCAPSULATED MICROBUBBLES AND MITIGATION OF BIOFOULING
    Publication number: 20190358352
    Abstract: Provided herein is a universally applicable biofouling mitigation technology using acoustically excited encapsulated microbubbles that disrupt biofilm or biofilm formation. For example, a method of reducing biofilm formation or removing biofilm in a membrane filtration system is provided in which a feed solution comprising encapsulated microbubbles is provided to the membrane under conditions that allow the encapsulated microbubbles to embed in a biofilm. Sonication of the embedded, encapsulated microbubbles disrupts the biofilm. Thus, provided herein is a membrane filtration system for performing the methods and encapsulated microbubbles specifically selected for binding to extracellular polymeric substances (EFS) in a biofilm.
    Type: Application
    Filed: February 24, 2017
    Publication date: November 28, 2019
    Inventors: Adnan QAMAR, Luca FORTUNATO, TorOve LEIKNES
  • LIGHTING DEVICE THAT DEACTIVATES DANGEROUS PATHOGENS WHILE PROVIDING VISUALLY APPEALING LIGHT
    Publication number: 20190358353
    Abstract: A lighting device configured to deactivate pathogens in an environment. The lighting device includes a housing, means for mounting the housing to a surface in the environment, one or more first light-emitting elements arranged in the housing and configured to each produce disinfecting light having a wavelength in a first range of wavelengths, and one or more second light-emitting elements arranged in the housing and configured to each produce disinfecting light having a wavelength in a second range of wavelengths different from the first range of wavelengths. The disinfecting light produced by the first light-emitting elements and the disinfecting light produced by the second light-emitting elements mix to form a combined light, the combined light being visible light other than white light.
    Type: Application
    Filed: August 12, 2019
    Publication date: November 28, 2019
    Inventors: James W. Hawkins, Nathan D. Heiking, Patrick J. Marry
  • SYSTEMS AND METHODS FOR SANITIZING AMUSEMENT PARK ARTICLES
    Publication number: 20190358354
    Abstract: A sanitization system for an amusement park includes a compartment disposed in a ride vehicle of an amusement park ride, where the compartment is configured to receive an article of the amusement park ride, an ultraviolet light source disposed in the compartment, where the ultraviolet light source is configured to transmit ultraviolet light toward a surface of the article when the article is positioned in the compartment, and a nozzle disposed in the compartment, wherein the nozzle is configured to direct a sanitizing fluid toward the surface of the article when the article is positioned in the compartment.
    Type: Application
    Filed: August 12, 2019
    Publication date: November 28, 2019
    Inventors: David Majdali, John Ugrin
  • PROCESS AND APPARATUS FOR CLEANING, DISINFECTION, STERILIZATION, OR COMBINATIONS THEREOF
    Publication number: 20190358355
    Abstract: Apparatus and methods are provided for cleaning, disinfecting, and/or sterilizing a device. More specifically, a first treatment chamber can be configured to conduct a first treatment stage therein at a first pressure, a first temperature, and a first sterilant concentration. A first passage can be operatively connected to the first treatment chamber and a second treatment chamber can be operatively connected to the first passage and in communication with the first chamber via the first passage. The second chamber can be configured to conduct a second treatment stage therein at a second pressure, a second temperature, and a second sterilant concentration. An object can be treated in the first treatment chamber and moved to the second treatment chamber via the first passage to be treated in the second treatment chamber.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventor: Morris Fuller Fox, III
  • CELL FOR ULTRAVIOLET IRRADIATION MODULE AND ULTRAVIOLET IRRADIATION MODULE
    Publication number: 20190358356
    Abstract: The present invention is intended to provide a cell for an ultraviolet irradiation module and an ultraviolet irradiation module with which it is possible to improve the efficiency of sterilizing an object to be irradiated to a greater extent than in the past. The cell for an ultraviolet irradiation module includes a case being at least partially formed of polytetrafluoroethylene having a crystallite size in a direction of 60 nm or more and 250 nm or less and having an internal space into which an object to be irradiated can be introduced.
    Type: Application
    Filed: January 31, 2018
    Publication date: November 28, 2019
    Applicant: ASAHI KASEI KABUSHIKI KAISHA
    Inventors: Keigo TAKEGUCHI, Sho SUGIYAMA, Hiroyuki KISHI
  • INTERFACE FOR FASTENING ATTACHMENT PARTS TO STERILE CONTAINERS
    Publication number: 20190358357
    Abstract: A container system includes a container or a sterile container to which an attachment part can be fastened. For this purpose, the sterile container has a fastening portion which is formed integrally with or integrally in a closed container wall of the container, to which the attachment part can be fastened in a positive fit or locked in a spring-elastic manner.
    Type: Application
    Filed: December 6, 2017
    Publication date: November 28, 2019
    Inventors: PHILIPP BOHNENSTENGEL, MATTHIAS HENKE, GEROLD ZIERIS, BOZICA FRECH, JOHANN MALIGLOWKA, SABRINA STEINER, STEPHAN BAUER, CORVIN MOTZ, JOACHIM AMANN, MICHAEL SCHEIT, MARTINA HÖFLER
  • INCENSE BURNER APPARATUS AND METHOD
    Publication number: 20190358358
    Abstract: An incense holder assembly and method of manufacture. The incense holder assembly has a base including a cavity, and an ash collector, and an upper housing including a first end with an incense material support including an incense aperture that can support an incense structure inserted into the incense aperture. An external cavity is positioned coupled to the incense material support and the ash collector, and a channel fluidly extends from the incense aperture to an internal cavity. The assembly also includes incense material support surfaces that can support the incense structure by coupling to a side of the incense structure. An incense material support surface is positioned within a channel or the internal cavity, and an incense material support surface is adjacent to or proximate the at least one aperture.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventor: Ethan Christopher Wessel
  • SEALED CONTAINER STRUCTURE
    Publication number: 20190358359
    Abstract: A sealed container structure includes a carrying container having a container body, a flange portion and an extension portion disposed at the periphery of the container body, a bending line provided at a boundary between the extension portion and the flange portion, a sealing film adhered on the flange portion and the extension portion and having a first portion and a second portion, and a depression line provided at a position of the first portion adjacent to the bending line. The first portion is adhered on the surface of the flange portion, and the second portion is adhered on the surface of the extension portion. The depression line has a protruding portion at the center part of the depression line. The protruding portion extends along a direction from the first portion toward the second portion, and protrudes beyond the bending line.
    Type: Application
    Filed: May 28, 2018
    Publication date: November 28, 2019
    Inventor: CHI-CHUAN HUANG
  • ODOR-CONTROL ABSORBENT MATERIALS AND ABSORBENT ARTICLES AND RELATED METHODS OF USE AND METHODS OF MAKING
    Publication number: 20190358360
    Abstract: Absorbent materials configured to sequester trimethylamine (TMA), absorbent articles made therefrom, related methods of use, methods of measuring a reduction of free TMA, and related methods of making absorbent articles are described.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 28, 2019
    Applicant: International Paper Company
    Inventors: Mary Virginia Schoolfield, Hugh West
  • WOUND DRESSING WITH APERTURED COVER SHEET
    Publication number: 20190358361
    Abstract: A wound dressing comprising an antimicrobial absorbent layer containing silver, and an apertured sheet covering the antimicrobial absorbent layer, wherein the apertured sheet is formed from a liquid-impermeable sheet material having an array of apertures therein, said apertures having a mean effective diameter of from about 0.5 mm to about 2 mm, and wherein the percentage open area of the apertured sheet is from about 7% to about 25%. The selection of apertures in this range provides enhanced antimicrobial efficacy.
    Type: Application
    Filed: June 7, 2019
    Publication date: November 28, 2019
    Inventors: Rachael Louise McInnes, Margaret Stedman, Sally Stephens, Simon Bayliff
  • CEMENT PRODUCTS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20190358362
    Abstract: Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Juchui Ray Lin, Edward S. Ahn, Brian M. Schlossberg
  • COMPOSITION FOR TISSUE REPAIR TREATMENT AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20190358363
    Abstract: Disclosed are a composition for tissue repair treatment using a non-toxic biocompatible polymer and a method for manufacturing the same. The composition includes a copolymer in which a hydrophobic biocompatible polymer and a hydrophilic biocompatible polymer are polymerized, and having a colloidal phase in which the copolymer is dispersed in water. The method including: preparing a polymer by polymerizing a hydrophobic biocompatible polymer and a hydrophilic biocompatible polymer; and obtaining a colloidal solution by adding the polymer to water.
    Type: Application
    Filed: May 13, 2019
    Publication date: November 28, 2019
    Applicant: DexLevo Inc.
    Inventors: Jae Won Yu, Myung Seob Shim, Jun Bae Kim
  • COMPOSITIONS AND METHODS OF MODULATING ENDOCHONDRAL OSSIFICATION AND BONE FORMATION
    Publication number: 20190358364
    Abstract: A method of modulating transdifferentiation of chondrocytes to osteoblast includes administering to the chondrocytes an agent that modulates GP130 receptor signaling and expression of at least one of Sox2, Oct4, or Nanog of the chondrocytes.
    Type: Application
    Filed: December 11, 2017
    Publication date: November 28, 2019
    Inventors: Eben Alsberg, Oju Jeon, Ralph Marcucio, Chelsea Bahney, Diane Hu, Sarah Knox