Abstract: A diverter is provided for use in directing airflow from an input port to selected output ports. The diverter allows for operation without valves, and is able to provide an air signal to selected output ports in a predetermined manner. The diverter having a rotatable member, or swivel valve, directing air signals to the desired output port depending on the rotational position thereof. The diverter is driven by a controlled actuator or motor, to thus control the manner in which air signals are provided to a plurality of output ports in a controlled manner.

Abstract: A body massager includes a portable housing including a backrest and a seat support. A longitudinal guide is provided in the backrest cooperating with a carriage for translation of the carriage within the backrest and a motor drives the carriage along the guide. A pair of massage members are supported by the carriage and extend from the backrest for imparting a rolling massage effect upon the back of the user. A second motor drives the massage members for generating a rotary kneading massage effect or for adjusting a width of the rolling massage effect.

Abstract: A massage tool comprising a cylindrical tube with a closed end and an open end, a plurality of balls disposed within the cylindrical tube, and a ring that surrounds the cylindrical tube and compresses the open end of the cylindrical tube closed. The cylindrical tube is comprised of flexible and stretchable material. The balls are inserted through the open end of the cylindrical tube and the balls are movable within the cylindrical tube. The ring is movable longitudinally across the outer surface of the cylindrical tube.

Abstract: A device for self-massage of the arm or leg and, that stimulates the circulation of the massaged member, improves the irregularities of the skin, strengthens the musculature of the massaging member, and allows the user to exercise one part of the body while massaging another part of the body. The self-massage device comprising a plurality of elastic straps attached to a central cord, each strap comprising a plurality of massage elements; and a handle part connected to the central cord and configured to enable the central cord to move in an upstream and downstream trajectory along the user's arm or leg.

Abstract: A remote system for sexual interaction is provided. The system may include an input device in communication with an output device including a phallic object. A motor is provided for moving the phallic object relative to movements associated with the input device.

Abstract: Systems and methods are provided for controlling infrared radiation (IR) sources of a sauna including tuning IR wavelength-ranges and radiated power-levels of IR sources, and directing IR to locations on a user's body. In one illustrative embodiment, a sauna may be provided having adjustable IR emitters to emit IR at any wavelength resulting in a desirable radiation treatment for the sauna user. In another illustrative embodiment, a method is provided for tuning IR emitters in a sauna.

Abstract: A pair of acupressure health care pants for applying acupressure to predetermined acupoints on a lower body of a user includes a pants body and an acupressure unit. The pants body is configured to elastically and tightly press against the lower body of the user when the pair of acupressure health care pants are worn by the user, and has a fiber base material mixed with a plurality of far infrared particles and negative ion particles. The acupressure unit includes a plurality of acupressure protrusions protruding from the fiber base material into an interior of the pants body and configured to apply acupressure to the lower body of the user at positions respectively corresponding to the predetermined acupoints.

Abstract: A holding fixture for a final fill container including a pair of rigid support structures. Each rigid support structure including an inner support having an inner surface with a radius of curvature with respect to a longitudinal axis, the inner surface facing radially inward, a support arm connected to the inner support and extending in an outward direction away from the inner surface, the support arm having a base surface at a terminal end opposite from the inner support; and a compression member attached to the inner surface, the compression member being configured to contact the shell at least when the their longitudinal axes are colinear. The pair of rigid support structures has a closed orientation when the compression member from one of the pair of rigid support structures contacts the compression member from the other one of the pair of rigid support structures forming a combined annular compression member.

Abstract: A blood sample collection tube and other vessels are described including an article surface and a coating set comprising a tie coating or layer of SiOxCy or SiNxCy applied to the article surface, a barrier coating or layer of SiOx, and a pH protective layer of SiOxCy or SiNxCy. The vessels optionally contain a fluid with a pH of 4 to 8, alternatively 5 to 9. The barrier coating or layer prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating or layer and pH protective coating or layer together protect the barrier layer from the contents of the vessel.

Abstract: This document provides devices and methods for monitoring and maintenance of the temperature of medical reservoirs and boxes in a secure fashion that enables for documentation of a chain of custody and history of temperature while in storage or transit. For example, this document provides devices and methods for monitoring the temperature of blood in phlebotomy tubes or boxes of biological products. In some embodiments of the devices and methods, the temperature of the contents of the medical reservoirs are regulated, modulated, and/or maintained by the devices provided herein.

Abstract: In certain embodiments, a vial access device for removing liquid contents from a vial includes a piercing member extending from a base of an insertion member and a reservoir. The reservoir can be contained within the piercing member and the insertion member, such that the reservoir is introduced to the vial when piercing member is inserted into the vial. The piercing member is adapted to be opened inside the vial to expose the reservoir to the contents inside the vial. A locking mechanism can prevent the piercing member from being inserted into the vial unless the vial access device is fully coupled to the vial and/or prevent the piercing member from being withdrawn from the vial without uncoupling the vial access device from the vial.

Abstract: An apparatus, method, and article of manufacture for transferring fluid contained in a syringe. The apparatus includes an airlock component having a cylindrical body with a first end, a second end, and a hollow tube disposed between the first end and the second end. An annular opening is located at the first end of the cylindrical body. The hollow tube includes a gas inlet aperture and a gas outlet aperture. The hollow tube also includes an inwardly-facing airtight material coupled to the interior surface of the hollow tube, and a septum coupled to the second end of the cylindrical body. The method includes transferring fluid from one container to a second container using the apparatus. The article of manufacture includes the apparatus, a syringe, and a needle.

Abstract: A fine needle dosing adaptor for dosing a fine needle syringe from a multi-dose vial has an adaptor body with an upper portion and a neck portion adapted to fit snugly within the neck of the multi-dose vial. A bore is centrally disposed within an upper portion of the adaptor body and has a diameter adapted to receive the hub of the fine needle syringe with a snug fit. An inverted funnel-shaped opening is centrally disposed within the neck portion of the adaptor body and needle chamber extends between the bore and the inverted funnel-shaped opening. The diameter of the needle chamber is slightly larger than an outer diameter of the needle and the length of the needle chamber is shorter than a length of the needle.

Abstract: In order to enable long-term stabilization of rapamycin contained in a liquid formulation, a formulation sealing vessel of the present invention includes: a sealed vessel body in which a liquid formulation containing 2% (w/w) rapamycin or a salt thereof, 94% (w/w) polyethylene glycol, and 4% (w/w) ethanol is sealed, the sealed vessel body having a volume of 0.1 mL to 1.0 mL, the liquid formulation containing no antioxidant, and the liquid formulation having a total volume of 0.02 mL to 1.0 mL.

Abstract: The invention relates to a pacifier (1) comprising a shield (6) and a teat (2) secured thereto. The teat (2) comprises a stem (3) in-terconnecting a first end portion (4) and a second opposite end portion (5) of the teat (2). The shield (6) comprises an elongated through-slot (8), which slot (8) has an opening (10) at one end thereof and a width being smaller than a cross-sectional diameter of the stem (3) of the teat (2). The stem (3) is compressed when inserted in the elongated through-slot (8), with the first (4) and second (5) end portions of the teat (2) located on opposite sides of the slot (8), and by that is the section of the stem (3) closest to the shield (6) given a smaller cross-sectional diameter than the section of the stem (3) closest to the first end portion (4) of the teat (2). The invention also relates to a method for producing such a pacifier (1).

Abstract: The invention relates to a curable composition for dental retraction comprising a resin matrix comprising at least one polyorganosiloxane with at least two olefinically unsaturated groups as component A1, at least one organohydrogenpolysiloxane as component A2, optionally at least one vinyl functional QM silicone component as component A3, at least one alkylsiloxane having at least one carbinol, silanol, or alkoxy moiety as component B, optionally surfactant(s) as component E, optionally additive(s) as component F, a filler system comprising filler(s) as component D, a catalyst system comprising addition cure catalyst component C-A suitable to cure components A1 and A2, condensation cure catalyst component C-B suitable to cure component B, the curable composition being provided as a kit of part comprising a Catalyst Part I and a Base Part II the Catalyst Part I comprising components C-A, C-B, A1, the Base Part II comprising components A2, A1, B, wherein each of components D, E and F and A3, if present, can be

Abstract: A composition includes a solvent, a powder that is present in the solvent and bears a first charge on its surface, an ionic polymer having a second charge that is opposite to the first charge, and a polyvalent ion having the first charge. The powder and the ionic polymer are electrostatically and/or ionically bonded with each other. The ionic polymer and the polyvalent ion are electrostatically and/or ionically bonded with each other.

Abstract: The invention relates to a cosmetic composition for application in the eye area in the form of a gelatinous emulsion, and to the preparation and use thereof.

Abstract: The present invention relates to an oral composition having improved ability of incorporating fluoride ions into tooth enamel and an enhanced remineralization effect. That is, the present invention provides an oral composition comprising an ingredient (A): 0.005 mass % or more and 2 mass % or less, in terms of fluorine atoms, of one or more fluoride ion-supplying compounds selected from the group consisting of sodium fluoride, ammonium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; an ingredient (B): 4 mass % or more and 30 mass % or less of a higher alcohol having 12 or more and 22 or less carbon atoms comprising (b1) cetanol and (b2) stearyl alcohol; an ingredient (C): 0.

Abstract: An antiperspirant/deodorant composition in the form of stick, cream, or flowable gel may include a carrier that may include a polyhydric alcohol or a mixture of a polyhydric alcohol and water; a thickening agent including a C14-22 fatty acid salt; and an antiperspirant active dispersed in the carrier. The antiperspirant active may include a layered silicate clay and/or an acyl substituted polyvinylpyrrolidone. The antiperspirant/deodorant composition may be primarily free of a C1-5 monohydric alcohol and a metal salt based antiperspirant active, such as aluminum-based antiperspirant active.

Abstract: Provided is a cosmetic composition containing metal oxide particles having improved dispersibility. A cosmetic composition contains metal oxide particles with an average particle diameter of 1 ?m or less and lepidocrocite-type platy titanate particles with an average unrolled diameter of 0.1 ?m to 10.0 ?m and an average thickness of 0.1 ?m to 4.0 ?m and the titanate particles are at least one selected from titanates expressed by chemical formulae K0.5-0.7Li0.27Ti1.73O3.85-3.95, K0.2-0.7Mg0.4Ti1.6O3.7-3.95, and K0.2-0.7Li0.27-(2x/3)MgxTi1.73-(x/3)O3.7-3.95 [where 0.004?x?0.4].

Abstract: Disclosed herein are hair care compositions and methods of using same. The compositions may be substantially anhydrous, and optically clear. The hair care compositions, when mixed with water, create an exothermic reaction, for example, when mixed with hair that has been pre-wetted. The mixture with water further causes the composition to become opaque, much like a traditional conditioning agent. The compositions may be left on the wetted hair and subjected to heat for enhanced treatment of the hair.

Abstract: A fragrance composition comprising one or more fragrance compounds for use in reducing or inhibiting a subject's physiological reaction to stress is disclosed. The composition can be incorporated into various consumer end products.

Abstract: Disclosed is a personal care composition and a method of providing antiperspirant and anti-inflammation using certain curcuminoid derivatives. The composition comprises: (i) a compound of the Formula 1 Ar—CHnCHn—X.C(R)2—X.CHnCHn—Ar (Formula 1) wherein Ar is a substituted or unsubstituted phenyl group; R is H or CH3; X is CH(OH) group or C?O group; n has the value 1 or 2; and, (ii) a topically acceptable base comprising at least 0.1% of a fragrance wherein, when n=1, the compound of (Formula 1) is 1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione (Formula 2), and when n=2, the compound of (Formula 1) is 1,7-bis(4-hydroxy-3-methoxyphenyl) heptane-3,5-diol (Formula 4) or is 1,7-bis (3,4-dimethoxyphenyl)-4,4-dimethylheptane-3,5-diol (Formula 5).

Abstract: Oral care composition for increasing deposition efficacy of a cooling sensate agent in the oral cavity. The oral care composition is made up of water and a calcium-containing abrasive to form a calcium-containing abrasive based carrier, and a cooling sensate agent comprising a N-substituted p-menthanecarboxamide containing compound.

Abstract: Cosmetic compositions are widely used to obtain certain benefits like e.g. anti-aging, skin lightening and moisturizing effect. These benefits are delivered by benefit agents (actives) like e.g. anti-oxidants, hyaluronic acid and resorcinol, pheynylethyl resorcinol and 4-alkyl substituted resorcinol. However, these actives have a certain shelf life beyond which they tend to degrade in terms of chemical activity and/or their color stability. The present invention discloses a novel process to prepare cosmetic compositions that improved color stability of resorcinol, pheynylethyl resorcinol and 4-alkyl substituted resorcinol and compositions comprising such actives when prepared as per said process.

Abstract: An oral care composition comprising zinc phosphate, stannous fluoride, arginine or lysine and an organic acid buffer system, as well as methods of using the same.

Abstract: The present disclosure provides biophotonic topical compositions and methods useful in phototherapy. In particular, the biophotonic topical compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

Abstract: The invention relates to a hair conditioning composition that exhibits high stability and transparency to give a smooth, grit free flow with no compromise on the desired sensorials when in use. This is achieved in a substantially silicone free composition with a judicious mix of cationic surfactant, selective antidandruff agent and octyldocecanol.

Abstract: A composition comprising a cosmetically or pharmaceutically or therapeutically effective amount of a peptide comprising an amino acid sequence of SEQUENCE ID NO. 1. Modified peptides, and therapeutic and cosmetic uses of the peptide are also disclosed.

Abstract: Disclosed herein are compositions comprising complexes of cyclodextrins and lipid-modified stem cell proteins. Also disclosed are topical compositions the complexes. Methods of using the compositions for the therapeutic purposes are also disclosed as well as methods of producing the compositions.

Abstract: The invention is about a silicone-in-water cosmetic comprising water, a high amount of polyhydric alcohol; a polyorganosiloxane dispersion; and a hydrophilic polymer, a polyorganosiloxane dispersion comprising polyorganosiloxane particles water and polyhydric alcohol; wherein the hydrophilic polymer is at least one of a polymer comprising as a repeating unit, (meth)acryloylalkyltaurine or a salt thereof and a polysaccharide. Such a silicone-in-water benefits from a nourishing effect and fresh watery effect in the same time. In addition no stickiness and slippery application are obtained.

Abstract: A method and kit for reconstituting broken fragments of a cosmetic, such as pressed powder cosmetics, are provided which enable a user to recombine or reconstitute such fragments in the original cosmetic packaging. The kit comprises a foamable liquid composition, spreading implement, and at least one pressing implement. Applying embodiments of the foamed liquid composition on fragmented cosmetic material, pressing or packing the mixture comprising the liquid composition and fragmented cosmetic material, and then smoothing the composition by pressing it again within its original casing, in accordance with embodiments of the method, may avoid wasting broken cosmetic fragments and further allows a consumer to use the reconstituted cosmetic for its original purpose.

Abstract: The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.

Abstract: A method for blocking, neutralizing, or killing microorganisms that cause infectious disease in a mammal prior to or during the mammal encountering a contaminated environment or item includes: identifying a contaminated environment or item, wherein the contaminated environment or item is known or expected to be contaminated with harmful viral, fungal, or bacterial microorganisms; and administering a therapeutically effective amount of a barrier-forming composition to a mucosa of the mammal prior to or during the mammal encountering the contaminated environment or item. The barrier-forming composition provides a barrier on the mucosa that inhibits the microorganisms from contacting the mucosa. Other related methods are also included.

Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Abstract: A composition suitable for topical application comprising a continuous phase and at least one discontinuous phase, said composition comprising at least one polyaphron dispersion, at least one vitamin D or vitamin D analogue and at least one corticosteroid.

Abstract: The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Abstract: The invention relates to the use of an oral bolus for drying-off cattle, preferably daily cattle, as well as methods of improving/facilitating the drying-off of cattle, reducing the milk production in pregnant and/or lactating cattle, decreasing milk accumulation in the udder of cattle, increasing the daily lying time of cattle, inducing a mild and temporary metabolic acidosis in cattle, reducing the dry matter intake (DMI) in cattle and/or reducing urine pH in cattle, preferably dairy cattle, comprising administering to such cattle at least one oral bolus, preferably on the last milking day and/or before dry-off.

Abstract: Disclosed is an optimized pharmaceutical formulation for the treatment of inflammatory conditions of the esophagus. A pharmaceutical formulation in the form of an orodispersible effervescent tablet is stable, easy to produce, and can be used without dissolving same in a liquid. It is not necessary to drink anything with the tablet as this would reduce the time that the budesonide solution remains in the affected regions of the esophagus. The effervescent tablet of the invention surprisingly resulted in an unexpectedly high rate of histological remission in patients with active eosinophilic esophagitis.

Abstract: The subject invention is directed to a pharmaceutical composition comprising an open matrix network incorporating one or more pharmaceutically active ingredients, wherein the open matrix network comprises maltodextrin and hyaluronic acid or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a lozenge comprising micronized benzocaine, at least one dissolution enhancer and one or more excipients as well as the use of the lozenge for the treatment of sore throat.

Abstract: A composition and method for administering an active agent to a pet, such as a dog, a cat or a horse. The composition may comprise a yogurt-based chewable delivery matrix and a plurality of water-soluble film pieces dispersed throughout the chewable delivery matrix. The composition may also comprise a delivery matrix having at least 15% by weight of crude protein and a plurality of water-soluble film pieces dispersed throughout the delivery matrix. The plurality of water-soluble film pieces encompass an active agent therein, wherein the active agent is rapidly released from the composition upon contact with saliva from the pet. At least a portion of the released active agents may be oromucosally absorbed by the pet.

Abstract: The invention relates to a tableted chewing gum suitable for active pharmaceutical ingredients, the chewing gum comprising a population of particles, the population of particles comprising a) directly compressible (DC) sugar alcohol particles, b) non-directly compressible (non-DC) sugar alcohol particles and c) particles comprising gum base, the gum base comprising at least 5% by weight of elastomer.

Abstract: Sub-micron emulsions and processes for their preparation are disclosed. In particular, sub-micron emulsion compositions containing pharmaceutically active ingredients, including delivery vehicles, such as foams, are disclosed. The emulsion compositions and foams may advantageously deliver pharmaceutically active ingredients, such as, for example, corticosteroids. The emulsions maintain stability over extended periods of time.

Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.

Abstract: This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: wherein each R is independently C1-6 alkyl; and n is an integer between 1 and 50.

Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.

Abstract: The invention comprises a solid dosage form for delivery of water soluble pharmaceutical agents. The solid dosage form comprises a matrix core containing the pharmaceutical agent and a hydrophobic material, and a coating containing a hydrophilic pore-forming agent and a hydrophobic polymer. The dosage form exhibits a zero-order release profile upon dissolution.