Abstract: The present disclosure relates to a device for detecting an analyte in a sample, and especially for detecting antigen/antibody reactions, wherein said device comprises a layer composed of a low-density immiscible compound. The disclosure also relates to a method for detecting an analyte in a sample and especially for detecting antigen/antibody reactions in a device comprising a layer composed of a low-density immiscible compound. The disclosure further relates to the uses of such low-density immiscible compound.

Abstract: Provided is a measurement device, including: a droplet forming part configured to form aerosol-like liquid droplets from a liquid in which a fluorescent substance specifically bondable to detection target particles and a specimen are mixed with each other; a droplet sorting part configured to sort droplets having a diameter smaller than a predetermined value from the droplets formed by the droplet forming part; and a measurement part configured to irradiate light onto the droplets sorted by the droplet sorting part and configured to measure the fluorescence intensity of the droplets.

Abstract: Disclosed herein are an artificial cell membrane including a supported lipid bilayer (SLB) including a substrate and mobility-decreased metal particles bonded onto the substrate; an analysis device or kit including the artificial cell membrane and examining the interactions between molecules, in which one molecule is bonded to the surface of a mobility-decreased metal particle bonded to the artificial cell membrane and the other molecule is bonded to the surface of a mobility-increased metal particle bonded to a lipid at a low valency; a method of examining the interactions between molecules using the analysis device; a kit for quantitative or qualitative analysis of a target material including the artificial cell membrane by plasmonic scattering measurements; and a multiple analysis kit capable of detecting a plurality of target materials using a plurality of metal particles having different plasmonic scattering wavelengths and/or having mobility on a supported lipid bilayer.

Abstract: A method for providing quality control on a lateral flow assay device or for triggering a process-related step, the device including a substrate having at least one sample receiving area, at least one reagent zone downstream and in fluid communication with the at least one sample receiving area, at least one detection zone downstream and in fluid communication with the at least one reagent zone and at least one wicking zone downstream of the at least one detection zone, each fluidly interconnected therewith along at least one fluid flow path. The detection material provided in the at least one reagent zone produces a detectable signal that can be tracked and monitored prior to the completion of at least one test being performed on the lateral flow assay device.

Abstract: An assay method and device can perform at least one (e.g., at least two) assays on a single aliquot of a sample liquid. The device can mix a sample liquid with assay reagents including magnetically susceptible particles. The device is configured to create a sample liquid-air interface with the sample liquid. The magnetically susceptible particles can be located (via an applied magnetic field) at the liquid-air interface when a second liquid contacts the interface to form a liquid-liquid interface. The magnetic particles travel across the liquid-liquid interface to the second liquid. The magnetically susceptible particles are configured to trans-port an analyte across the interface into the second liquid. An assay for the analyte is performed in the second liquid. An assay for another analyte can also be performed in the sample liquid.

Abstract: Provided are a method for diagnosing chronic inflammatory demyelinating polyneuropathy (CIDP), in particular, a diagnostic method for specifically diagnosing a group having a specific pathophysiology among CIDPs, and a kit and a biomarker for use in such a diagnosis. The diagnostic method for diagnosing CIDP of the present invention includes a step of measuring an anti-neurofascin 155 antibody contained in a sample.

Abstract: Disclosed are bladder cancer protein biomarkers, methods of determining whether a patient suffers from or shows recurrence of bladder cancer or early stage bladder cancer, or late stage bladder cancer using the bladder cancer protein biomarkers, a detection system, and kits thereof. Said bladder cancer biomarkers comprise at least one of Coronin-IA, Apolipoprotein A-IV, Semenogelin-2, Gamma-synuclein and DJ-1, and variants thereof.

Abstract: This invention relates to antibody drug conjugates (ADC), antibody conjugates (AC) and novel antibodies. Particularly, the ADC, AC and antibodies disclosed herein specifically bind to the human anti-Müllerian hormone type II receptor (AMHR-II) and can be used to treat and/or identify AMHR-II expressing cancers, such as prostate cancer, breast cancer and gynecologic cancers expressing AMHR-II, such as ovarian cancer, in particular metastatic ovarian cancer, serous cancer, hypernephroma, endometrioid, colloidal epithelium, prostate cancer, germ cell cancer, endometrial cancer, mixed Müllerian malignant tumor of the uterus, leiomyosarcoma, or endometrial stromal sarcoma.

Abstract: Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be selected/identified based upon a lower level of fluorescence of the fluorescent glucose analog compared to non-cancer stem cells and that specific genes are differentially expressed in leukemia stem cells compared to non-leukemia stem cells.

Abstract: This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-? (FR-?). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-?”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.

Abstract: The invention relates to an antibody or an antigen-binding fragment thereof, including a heavy chain and a light chain, with heavy chain complementarity determining regions 1 to 3 having the amino acid sequences of SEQ ID NOS. 1 to 3, respectively, and light chain complementarity determining regions 1 to 3 having the amino acid sequences of SEQ ID NOS. 4 to 6, respectively. In addition, the invention relates to an anti-cancer therapeutic agent including the antibody or the antigen-binding fragment thereof.

Abstract: Provided are: a phosphor-integrated nanoparticle labeling agent which is capable of yielding a sufficient signal intensity even when its final concentration in an immunofluorescent staining reaction system is low (e.g., 0.02 nM) and enables to obtain an immunofluorescently stained image with reduced noise by inhibiting non-specific adsorption of a probe biological substance and a label to substances other than a detection subject; and an immunostaining method using the same. The phosphor-integrated nanoparticle labeling agent is a set which includes: a probe biological substance 3, which is linked to a first binding group substance A via a first hydrophilic polymer-derived spacer 1 having a length of 30 ? to 1,000 ? and specifically binds to a biomolecule 2; and a phosphor-integrated nanoparticle 5, which has a second binding group substance B capable of specifically binding to the first binding group substance A.

Abstract: The glycemic index is determined based on the results of blood glucose concentration measurements by evaluating time ?t from the beginning of food-related increase of blood glucose concentration until the peak of glucose concentration is reached, after which maximum increase ?Gmax of said glucose concentration is determined over the given period of time. Thereat, the glycemic index of food is defined as a ratio of maximum increase of blood glucose concentration ?Gmax versus maximum increase of said glucose concentration in case of pure glucose intake in the amount equal to carbohydrate content of the consumed food, which is proportional to the product of ?Gmax by ?t. The invention substantially simplifies the procedure for measuring the glycemic index of real food and facilitates the development of simple personal devices for monitoring carbohydrate metabolism.

Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided is a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

Abstract: The present teachings relate to methods, systems, and kits for analyzing a sample containing a glycopeptide of interest that can subject the glycopeptide of interest to a plurality of parallel deglycosylation reactions that differentially cleave the glycan, with the various products resulting from the deglycosylation reactions being differentially labeled (e.g., with isobaric and/or isomeric labeling reagents) to thereby produce labeled glycopeptides or labeled fragments of the glycopeptides. The products of the various deglycosylation reactions can then be mixed together and subject to LC-MS/MS using a single injection of the mixture. In accordance with various aspects, by associating the resulting mass spectral data with a particular deglycosylation reaction (e.g., based on the presence in the MS/MS data of product reporter ions associated with the particular differential labels), the methods and systems described herein can aid in the identification of the glycan structure.

Abstract: Provided is a method for identifying pregnancy failure in a subject, the method comprising determining a concentration of at least one element of fetal or embryonic origin in the vaginal fluid of the subject; and comparing the concentration of the at least one element of fetal or embryonic origin to a reference value, wherein when the concentration of the at least one element of fetal or embryonic origin in the vaginal fluid is higher than the reference value, pregnancy failure is indicated.

Abstract: The present invention provides a method for predicting whether a human patient 65 years of age or older is at increased risk for developing heart failure, comprising obtaining the results of an assay that measures levels of NT-proBNP and/or cardiac troponin T in a specimen from the patient wherein an increased NT-proBNP and/or cardiac troponin T level compared to levels in a control indicate an increased risk for developing heart failure.

Abstract: The disclosure provides methods for the diagnosis of Huntington's disease. In some embodiments, the method comprises detecting one or more repeat associated non-ATG (RAN) proteins in a biological sample.

Abstract: Components for enabling immunodection of indazole synthetic cannabinoids are described including immunogens, haptens, antibodies, methods and kits.

Abstract: A method and a device for handling sample tubes are presented. A position of the sample tube is identified and the sample tube is handled depending thereon.

Abstract: A first rack of a first color and a second rack of a second color respectively hold blood collecting tubes. After a test is finished, the first and second racks are disposed at a carrying-out section. A result screen showing a test result includes a first region of the first color and a second region of the second color. The first and second regions are displayed in positions corresponding to positions of the first and second racks in the carrying-out section. First symbols are displayed in the first region at positions corresponding to positions of the blood collecting tubes held in the first rack. Second symbols are displayed in the second region at positions corresponding to positions of the blood collecting tubes held in the second rack. A displayed appearance of each of the first and second symbols is changed in accordance with the test result.

Abstract: A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. The method is adapted to compensate deviations regarding physical properties of the sample container carriers, the transport plane and the electro-magnetic actuators compared to reference components. A laboratory automation system comprising such a laboratory sample distribution system is also presented.

Abstract: A sensor housing for a wheel-sensor device for a vehicle includes a first receiving aperture, a second receiving aperture, a first rotational-speed sensor, a rotary transducer, and a second rotational-speed sensor. The first sensor is configured to be inserted into the first aperture, and the sensor housing with the inserted first sensor is configured to be mounted on the vehicle. The rotary transducer is configured to co-rotate with a vehicle wheel and to trigger a change in a first physical quantity. The second sensor is configured to be inserted adjacent to the first sensor in the first aperture or in the second aperture, and the sensor housing, with the inserted first and second sensors, is configured to be mounted on the vehicle. The rotary transducer co-rotating with the rotating wheel triggers the change in the first physical quantity and a change in a second physical quantity.

Abstract: A physical quantity sensor includes: a detection element that outputs a sensor signal in accordance with a physical quantity; and a mount member. The detection element includes a sensor portion that has a first surface, includes a movable electrode, and a fixed electrode, and outputs the sensor signal, and a cap portion that has a first surface and is bonded with the sensor portion. Each of the first surface of the sensor portion and the first surface of the cap portion is mounted on the mount member, and the detection element detects the physical quantity. An electrode, which is connected with the movable electrode and connected with a circuit portion, and an electrode, which is connected with the fixed electrode and connected with the circuit portion, are provided on a side surface continued to the first surface of the cap portion.

Abstract: A test wafer having two spaced-apart accelerometers mounted thereon is disclosed. The accelerometers may be positioned at locations located along a common axis passing through the center of gravity of the test wafer. The test wafer may include a controller that may be used to transmit acceleration data collected by the accelerometers to another device. In some implementations, a semiconductor processing tool is provided that includes a test wafer receptacle for storing a test wafer that remains with the semiconductor processing tool and that may be retrieved by a wafer handling robot for performing a test cycle during periods when the wafer handling robot is not performing substrate transport operations.

Abstract: Radio frequency (RF) probes are provided herein having a spherical shaped probe tip. The RF probes include a main body extending from a probe housing, and a contact portion integrally formed with the main body and extending radially from the main body. The contact portion includes a tip, with at least a portion of the tip having a spherical outer surface. The probe tip can be formed such that it extends from the contact portion at a predetermined angle. The probe tip can be formed having a spherical contact surface to provide a reduced contact area as compared to other probes having non-spherical shapes. The spherical contact surface can be configured to reduce accumulation of material from a surface of a device being tested and/or reduce damage to the surface of the device being tested.

Abstract: A contactless radio frequency (RF) probe. The RF probe includes a dielectric substrate, at least one waveguide comprising an electric field configured to increase the coupling between the dielectric substrate and the at least one waveguide, and an air gap separating the dielectric substrate and the at least one waveguide to prevent thermal loading, thermal expansion, and material deformity.

Abstract: The present disclosure discloses a conductivity sensor including a basic body of sintered ceramic having at least two cavities disposed on a frontal face and a metal electrodes disposed in each cavity. Each electrode is about one fifth the length of the basic body. Electrical cables extend from a rear face of the basic body into holes in each cavity and contact the electrodes. A solder paste or an electrically conductive adhesive disposed in each hole connects each cable with the respective metal electrode electrically and mechanically.

Abstract: A probe card for a testing apparatus of electronic devices comprises at least one testing head which houses a plurality of contact probes, each contact probe having at least one contact tip suitable to abut onto contact pads of a device under test, and a support plate of the testing head associated with a stiffener and an intermediate support, connected to the support plate and suitable to provide a spatial transformation of the distances between contact pads made on opposite sides thereof. Conveniently, the probe card comprises a support which is joined to the intermediate support, which is made of a material compatible with the printed circuit board technologies and has a coefficient of thermal expansion greater than 10×10?6° C.?1, the support being made of a metal material having a coefficient of thermal expansion lower than 6×10?6° C.?1.

Abstract: The instant disclosure provides a probe assembly and a probe structure thereof. The probe structure includes a metal main portion, a covering layer and an insulating layer. The metal main portion has a first end portion, a second end portion corresponding to the first end portion, a connecting portion connected between the first and the second end portions and a surrounding surface surrounding the first end portion, the second end portion and the connecting portion. The covering layer includes a first covering layer disposed on a surrounding surface located on the first end portion, a second covering layer disposed on a surrounding surface located on the second end portion and a third covering layer disposed on a surrounding surface located on the connecting portion. The insulating layer is disposed on the third covering layer for exposing the first and second covering layer.

Abstract: A current sensor can indirectly measure a sensed current by directly measuring static perturbing AC magnetic fields with magnetoresistance elements, the perturbing magnetic fields generated by perturbing coils. The sensed current can be indirectly measured by modulating or changing sensitivities of the magnetoresistance elements in a way that is directly related to the sensed current.

Abstract: The apparatus for detecting current includes: a charging stage having one end connected to a power source and another end connected to an inductor and configured to charge the inductor with a current; a discharging stage having one end connected to the inductor and another end connected to ground potential and configured to discharge the current charged in the inductor; and a detecting stage configured to detect a magnitude of a current flowing through the inductor based on a first output voltage output from a first output node of the charging stage when the inductor is charged by the charging stage or on a second output voltage output from a second output node of the discharging stage when the inductor is discharged by the discharging stage.

Abstract: Disclosed herein are methods, systems, and devices for identifying computational operations based on power measurements. Disclosed herein are systems that may include a phase measurement unit configured to generate a first measurement based on a power signal, the first measurement characterizing a phase angle of the power signal. The systems may also include a power measurement unit configured to generate a second measurement based on the power signal, the second measurement characterizing an amplitude of one or more aspects of the power signal. The systems may further include a processing unit configured to identify a computational operation implemented by a target processing device, the identifying of the computational operation being based on a comparison of the first measurement and the second measurement with reference measurements.

Abstract: A system (with corresponding methods) for responding to an electrical meter alarm. The system utilizes a processor at a meter or at a utility, and an alarm chronical encoded in memory of the processor. The alarm chronical includes an alarm level correlating to a degree of risk associated with a state of the meter, a time stamp including a date and a time of when the alarm level triggered, a meter identification, and performance data of the meter.

Abstract: An electronic apparatus for measuring a frequency of an electromagnetic signal emitted from a coordinate indicating device contacting a sensor pad, and method are provided. The electronic apparatus includes a signal receiving unit that receives the electromagnetic signal, a band-pass filter unit including a pair of band-pass filters that generates a first filtered signal and a second filtered signal by respectively filtering the electromagnetic signal in a first frequency range and a second frequency range corresponding to a center frequency of the coordinate indicating device, and a controller that acquires a frequency value of the electromagnetic signal based on a ratio value between the first filtered signal and the second filtered signal.

Abstract: Systems and methods provide measurement of one or more electrical parameters (e.g., impedance) of a device under test (DUT) using an electrical parameter measurement device (e.g., multimeter, oscilloscope) that includes reference signal circuitry that generates, detects, and processes common mode reference signals. A measurement device may include a known common mode AC reference voltage source coupled to a common input terminal. During measurement of a DUT, circuitry may detect a signal at a voltage test input terminal and a signal at the common input terminal. The circuitry may process the first and second signals to determine one or more electrical parameters of the DUT, which one or more electrical parameters may be used to implement one or more features. The determined electrical parameters may be presented to an operator via a visual indicator device and/or may be communicated to an external device via a wired and/or wireless communications interface.

Abstract: Embodiments of the invention provide a capability of determining an input impedance of a connected Device Under Test based on Waveform Monitoring of an output signal of a waveform generator. Using embodiments of the invention, the input impedance of DUT is determined from the waveform monitoring results. The impedance information of the DUT together with the actual waveform provided to the DUT allows systems according to embodiments of the invention capable of characterizing circuit behavior for performance optimizing and issue debugging for the DUT.

Abstract: In a general aspect, fields of electromagnetic radiation are imaged. In some aspects, an imaging method includes receiving electromagnetic radiation at a vapor-cell sensor. The method also includes passing beams of light through the vapor-cell sensor, one or more of the beams of light reflecting off a dielectric mirror of the vapor-cell sensor. The method additionally includes receiving at least one of the beams of light at an optical imaging system. The optical imaging system is configured to measure spatial properties of a beam of light. The method also includes determining one or both of an amplitude and a phase of the electromagnetic radiation based on spatial properties of the at least one received beam of light. Systems for imaging fields of electromagnetic radiation are also presented.

Abstract: A device, in at least two measuring intervals, detects a respective operating state of at least one power converter of the motor vehicle, which is conductively connected to the traction energy store. The device further comprises a measuring device having a measuring terminal, which is conductively connected or connectable to least one DC voltage pole of an electric traction energy store of the motor vehicle, and a ground terminal which is conductively connected or connectable to a reference potential of the motor vehicle. The measuring device, in the at least two measuring intervals, respectively measures a conductance between the measuring terminal and the ground terminal. The device further comprises a calculation device, which determines the insulation resistances as a function of the at least two measured conductances and the at least two operating states detected.

Abstract: A method for detecting an arc fault in AC circuits. The method includes monitoring disturbances in an AC voltage signal by analyzing multi-dimensional energy points. A voltage signal is captured and the zero-crossing, minimum peak, and maximum peak are identified. Arcing signatures between the maximum and minimum peaks of the captured AC voltage signal are analyzed to detect an arc fault.

Abstract: A bypass diode with a disconnection fault is identified. A test device includes: a signal introduction circuit that applies a disconnection position identification signal to between a positive electrode and a negative electrode of a solar battery string; and a fault calculating part that identifies the bypass diode with a disconnection fault on the basis of an AC component of a voltage between a frame ground and the positive electrode or an AC component of a voltage between the frame ground and the negative electrode when the disconnection position identification signal is applied.

Abstract: After measuring electrical characteristics, a component favorably drops from a measuring element. An inspection device includes a pair of measuring elements configured to measure electrical characteristics of a component by gripping the components due to being capable of approaching and separating from each other; and air supply device configured to supply air to at least one of a pair of opposing surfaces that oppose each of the pair of measuring elements, and by supplying air to at least one of the opposing surfaces from air supply device, a component s adhered to the at least one opposing surface can be caused to drop favorably.

Abstract: Disclosed are a method and a device for detecting a short circuit between adjacent micro-bumps. The method includes setting outputs of a pull-up driver and a pull-down driver of a data output circuit connected with a micro-bump to be suitable for a test type and determining whether a short circuit is generated.

Abstract: A method for probe card alignment is provided. The method includes providing a probe card with a plurality of probe needles having their distal ends on a reference plane. The method further includes providing a light from both the upper side and lower side of the reference plane. The method also includes using a camera to image the probe needles. In addition, the method includes performing a probe card alignment process according to the image generated by the camera.

Abstract: Various aspects of the disclosed technology relate to using capture-per-cycle test points to reduce test application time. A scan-based testing system includes a plurality of regular scan chains and one or more capture-per-cycle scan chains on which scan cells capture and compact test responses at predetermined observation points per shift clock cycle.

Abstract: Disclosed herein are exemplary methods, apparatus, and systems for performing timing-aware automatic test pattern generation (ATPG) that can be used, for example, to improve the quality of a test set generated for detecting delay defects or holding time defects. In certain embodiments, timing information derived from various sources (e.g. from Standard Delay Format (SDF) files) is integrated into an ATPG tool. The timing information can be used to guide the test generator to detect the faults through certain paths (e.g., paths having a selected length, or range of lengths, such as the longest or shortest paths). To avoid propagating the faults through similar paths repeatedly, a weighted random method can be used to improve the path coverage during test generation. Experimental results show that significant test quality improvement can be achieved when applying embodiments of timing-aware ATPG to industrial designs.

Abstract: A stimulus/response controller within a magnetic electrical test apparatus is configured for generating and transmitting stimulus waveforms to a high-speed DAC for application to a MTJ DUT. The response signal from the MTJ DUT is applied to an ADC that digitizes and transfers the response signal to the stimulus/response controller. The stimulus/response controller has a configurable function circuit that is selectively configured for performing evaluation and analysis of the digitized stimulus and response signals. The configurable functions are structured for performing any evaluation and analysis function for determining the characteristics of the MTJ DUT(s). Examples of the evaluation and analysis operations include averaging the stimulus and/or response signals, determining the differential resistance, the degradation times, failure counts, or the bit error rate of the MTJ DUT(s).

Abstract: A diagnostic test is conducted by operating an engine-generator set at a plurality of reduced speeds. At each of those speeds, operating parameters of the engine are sensed and analyzed to detect an unsatisfactory operating condition. For example, such operating parameters may include speed of the engine-generator set, engine oil pressure and level, engine temperature, coolant level, and battery voltage. When a transition in engine speed occurs, a throttle test also may be conducted to measure how quickly and smoothly the engine reaches the new speed. After the engine reaches the normal operating speed, the generator is activated to produce electricity. One or more characteristic of that electricity, such as voltage, current and frequency, are sensed and evaluated to detect an unsatisfactory operating condition.

Abstract: In an embodiment, a device comprises a controller configured to create a load pulse for a battery, measure battery voltage concurrently with the load pulse, measure battery current concurrently with the load pulse, calculate a battery resistance from the measured battery voltage and current and based on the battery resistance, calculate a maximum allowable current extractable from the battery, wherein the maximum allowable current is determined such that a voltage across the battery does not drop below a pre-specified threshold voltage when the maximum allowable current is drawn from the battery.

Abstract: A battery state estimation method and apparatus are provided. Sensing data of a battery is received, and feature information is acquired by preprocessing the sensing data. The preprocessed sensing data is selected based on the feature information, and state information of the battery is determined based on at least one of the selected preprocessed sensing data or previous state information of the battery.