Abstract: The invention relates to a material represented by the following formula (I) (M?)8M?6M??6O24(X,S)2:M????formula (I). Further, the invention relates to an ultraviolet radiation sensing material, to an X-radiation sensing material, to different uses, to a device and to a method for determining the intensity of ultraviolet radiation.

Abstract: Embodiments of the invention include a semiconductor light emitting device with a light emitting layer disposed between an n-type region and a p-type region. The light emitting layer emits first light. The device further includes AE1-xLi2Be4O6:Eux, wherein AE=one or more of Sr, Ba, Ca, disposed in the path of the first light. The AE1-xLi2Be4O6:Eux absorbs first light and emits second light. In some embodiments, the first light and second light may be blue.

Abstract: Polymer microparticles spatially and spectrally encoded using upconversion nanocrystals (UCN) are described for labeling of articles and tissues. UCN having spectrally distinguishable emission spectra are disposed in different portions of an encoding region of each microparticle.

Abstract: Methods, apparatuses and systems are disclosed for chemically etching parts by generating an enclosed chemical etching chamber in contact with a part surface and directing a flow of chemical etchant solution in contact with a part region to be etched.

Abstract: The present invention relates to a liquid-crystalline medium based on a mixture of polar compounds having negative dielectric anisotropy (??), which is distinguished by the fact that it has a value for the ratio ?1/?n2 in the range 6-45 with a clearing point of >60° C. and a ?? of ??2.3. Media of this type are particularly suitable for electro-optical displays having active-matrix addressing based on the ECB, PA LCD, FFS or IPS effect.

Abstract: The disclosure provides a liquid crystalline compound that has at least one of physical properties such as high stability with respect to heat and light, a high clearing point (or a high upper limit temperature), a low lower limit temperature of a liquid crystal phase, a low viscosity, suitable optical anisotropy, large negative dielectric anisotropy, a suitable elastic constant, favorable compatibility with other liquid crystalline compounds at room temperature and low temperatures, a liquid crystal composition including the compound, and a liquid crystal display element including the composition. The compound is represented by Formula (1). Here, R1 is an alkyl group having 2 to 10 carbon atoms in which one —CH2CH2— is substituted with —CH?CH—; R2 is an alkyl group having 1 to 8 carbon atoms; ring A1 is 1,4-cyclohexylene; Y1 and Y2 are hydrogen or fluorine; Z1 is a single bond; and n1 is 1 or 2.

Abstract: A liquid crystal composition including: a polymerizable liquid crystal compound capable of expressing birefringence with inverse wavelength dispersion; a surfactant containing a fluorine atom; and a solvent, wherein the surfactant contains a fluorine atom at a ratio of 30% by weight or less in a molecule of the surfactant.

Abstract: Products from a high pressure processing system are separated and purified. The processing system is adapted for pressurizing and heating a feed mixture comprising carbonaceous material(-s) in the presence of homogeneous catalysts and liquid organic compounds to produce a converted feed mixture. The converted feed mixture is cooled and depressurized, and then separated into: a gas phase, an oil phase, and a water phase comprising liquid organic compounds and dissolved homogeneous catalysts comprising potassium and/or sodium. The liquid organic compounds and dissolved homogenous catalysts are at least partly recovered from said water phase, thereby producing a first water phase stream enriched in liquid organic compounds and homogeneous catalysts and a second water phase stream depleted in liquid organic compounds and homogeneous catalysts. The first water phase is at least partly recycled to the feed mixture, with a bleed stream being withdrawn therefrom prior to recycling.

Abstract: A method for producing a hydrocarbon liquid fuel including hydrocracking a raw material oil in the presence of a hydrocracking catalyst, at a supplying pressure of hydrogen of from 0.1 to 1.0 MPa, a liquid space velocity of liquid volume of the raw material oil of from 0.05 to 10.0 hr?1, and a flow rate of the hydrogen from 50 to 3,000 NL per 1 L of the raw material oil, wherein the hydrocracking catalyst is produced by a method including stirring a sulfur compound and a cracking catalyst in an aqueous medium to allow liquid-solid separation (step 1); stirring a solid product obtained in the step 1 and a metal component in an aqueous medium to allow liquid-solid separation (step 2); baking a solid product obtained in the step 2 (step 3); and reducing a solid product obtained in the step 3, or reducing a solid product obtained in the step 3, and then subjecting a reduced product to sulfurization treatment (step 4).

Abstract: A multi-stage process for transforming a high sulfur ISO 8217 compliant Feedstock Heavy Marine Fuel Oil involving a core desulfurizing process that produces a Product Heavy Marine Fuel Oil that can be used as a feedstock for subsequent refinery process such as anode grade coking, needle coking and fluid catalytic cracking. The Product Heavy Marine Fuel Oil exhibits multiple properties desirable as a feedstock for those processes including a sulfur level has a maximum sulfur content (ISO 14596 or ISO 8754) between the range of 0.05 mass % to 1.0 mass. A process plant for conducting the process is also disclosed.

Abstract: The invention concerns a process and a facility for reducing the concentration of heavy polycyclic aromatic compounds (HPNA) in the recycle loop of hydrocracking units, which comprises a fractionation column. In accordance with this process, a portion of the stream present at the level of at least one plate (I) which is the supply plate or a plate located between the supply plate and the residue evacuation point, or if stripping gas is injected, between the supply plate and the stripping gas injection point, is withdrawn from the fractionation column. A portion, preferably all, of the withdrawn stream is recycled to the hydrocracking step directly or after optional separation of the gases. The residue is purged in its entirety.

Abstract: The present invention relates to a combustor-independent fluidized bed indirect gasification system for technology for obtaining high quality synthetic gas through effective indirect gasification of low quality fuels, such as biomass/waste/coal, having various properties, and provides a combustor-independent fluidized bed indirect gasification system comprising: a pre-processor having a sorter 500; a gasifier 300 to which a first fuel sorted in the pre-processor is supplied; a combustor 100 to which a second fuel sorted in the pre-processor is supplied; and a riser 200 connecting the gasifier 300 and the combustor 100 and having functions of increasing the temperature of a bed material and transferring the bed material therein.

Abstract: A composition of fuel additives includes at least a first additive having a partial ester derivative of polyols and a second additive having a quaternary ammonium salt. The first additive includes at least 50% by mass of a compound A selected from the partial esters of polyols and saturated or unsaturated, linear or branched, cyclic or acyclic C4 to C36 monocarboxylic aliphatic hydrocarbarbons, the partial esters being able to be used alone or in a mixture. The disclosure also relates to a diesel fuel including such a composition and the use of the fuel for limiting the deposits in a diesel engine. In particular, the disclosure relates to the use of the fuel containing the composition of additives of the present disclosure in direct-injection diesel engines.

Abstract: A method for producing fatty acid alkyl esters and glycerol implementing a set of transesterification reactions between at least one vegetable or animal oil and at least one aliphatic monoalcohol includes: introducing, into a three-dimensional microball mill at least one vegetable and/or animal oil, at least one aliphatic monoalcohol and at least one heterogenous and/or homogenous catalyst in order to form an initial mixture; grinding the initial mixture at a temperature?50° C., in a three-dimensional microball mill, for a residence time?5 minutes; recovering, at the outlet of the three-dimensional mill, a final mixture including at least fatty acid alkyl esters, glycerol, the catalyst and the aliphatic monoalcohol that has not reacted; and separating this final mixture of a first phase including the fatty acid alkyl esters and of a second phase including the glycerol, the aliphatic monoalcohol that has not reacted and the catalyst.

Abstract: This disclosure relates to a cleaning composition that contains 1) at least one redox agent; 2) at least one organic solvent selected from the group consisting of water soluble alcohols, water soluble ketones, water soluble esters, and water soluble ethers; 3) at least one metal-containing additive; and 4) water.

Abstract: Applicants have developed a physically and chemically stable solid composition containing a soil release polymer and an acidulant. The sour step thus accomplishes both stain removal and residual alkalinity removal. A novel method of using a soil release polymer and an acidulant together in the same post wash step of a laundry wash process is also disclosed. The solid composition is physically stable, even during aqueous dispensing, i.e. non-slumping and non-weeping. The solid could be formed through a melt, cast, or pressed process.

Abstract: A membrane photobioreactor for treating nitrogen and phosphorus that are out of limits in a biogas slurry and treating method thereof, relating to biogas slurry treatment. The membrane photobioreactor for treating nitrogen and phosphorus that are out of limits in a biogas slurry is provided with a biogas slurry storage tank, peristaltic pumps, a microalgae cultivating tank, an air pump, a membrane photobioreactor and a hollow fiber membrane.

Abstract: A tempering device for tempering of biomass contained in a container, including at least one tempering mechanism, and at least one conveying device for conveying a mass flow of biomass in a main flow direction. The at least one conveying device includes at least one agitator, and wherein the at least one tempering mechanism is arranged in the main flow direction generated by the at least one conveying device. The at least one tempering mechanism is tubular with an inner tube and with an outer tube arranged coaxially to the inner tube. The inner tube and the outer tube form an intermediate space through which a tempering medium may flow. The tempering mechanism is oriented relative to the conveying device such that, in operation of the heating device, at least 40% of the delivery volume of the mass flow generated by the conveying device flows through the inner tube.

Abstract: An electromagnetic biostimulation apparatus and method includes a container with an outer wall, a bottom, and a top such that an open interior space is formed. Several biotubes are located within the container and an energy transmission device is provided where the energy transmission device is directed at less than all of the several biotubes. A laser beam and optical density reader device combination is provided where the optical density reader device obtains data from the laser beam related to each of the several biotubes.

Abstract: In a method for producing a cell concentrate using a cell suspension treatment system including a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port, a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane, a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, a collection container of a cell concentrate obtained by concentration, a collection path for feeding the cell concentrate to the collection container, an injection path for injecting a solution into the solution inlet port of the storage container, and a detecting unit.

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

Abstract: The present invention relates to a process for the production of squalene and/or sterol in high amounts using an alkaline solution and an organic lysis solvent at high temperature and high pressure for effectively lysing yeast cells and extracting squalene and/or sterol into an organic extraction solvent, thus obtaining squalene and/or sterolin high amount and of high purity.

Abstract: The present invention provides a joint method of cultivating microalgae combined with denitrating an industrial waste gas and a system useful for the same. The joint method comprises the steps of: (1) a step of cultivating microalgae; (2) a separation step of separating a microalgae suspension obtained from step (1) into a wet microalgae (microalgae biomass) and a residual cultivation solution; (3) a NOx absorbing/immobilizing step of denitrating an industrial waste gas with the residual cultivation solution obtained from step (2); wherein the nutrient stream absorbed with NOx obtained from step (3) is used to provide nitrogen source to the microalgae cultivation of step (1). During the microalgae cultivation, EM bacteria is added into the microalgae suspension. The microalgae is preferably Chlorella sp., Scenedesmus sp., Monoraphidium sp. or Spirulina sp.

Abstract: A novel method of growing fungi is disclosed which uses an engineered artificial media and produces high density filamentous fungi biomats that can be harvested with a minimum of processing and from which fungal products such as antibiotics, proteins, and lipids can be isolated, the method resulting in lowered fungus cultivation costs for energy usage, oxygenation, water usage and waste stream production.

Abstract: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.

Abstract: Cancer immunotherapy using genetically engineered NK cells is enhanced by expression of recombinant co-stimulatory molecules to deliver co-stimulatory signals to a recipient host's immune cells to enhance an immune response.

Abstract: The problem to be solved by the present invention is to provide a cultured cell sheet that expresses phenotypes of the chondroid tissue. The problems can be solved by producing the cultured cell sheet in which cells are cultured on a surface of a cell cultureware that is coated with a temperature responsive polymer having an upper or lower critical solution temperature ranging from 0° C. to 80° C. in water, including steps of: adjusting the temperature of the culture medium to a temperature below the lower critical solution temperature or above the upper critical solution temperature; bringing the cultured cell sheet in close contact with the carrier; and detaching the cultured cell sheet together with the carrier.

Abstract: Provided herein are genetically engineered Pichinde viruses that include three ambisense genomic segments. The first genomic segment includes a coding region encoding a Z protein and a coding region encoding a L RdRp protein. The second genomic segment includes a coding region encoding a nucleoprotein (NP) and the third genomic segment includes a coding region encoding a glycoprotein. Each of the second and third genomic segments optionally include an additional coding region that may encode an antigen or a detectable marker. Also provided herein is a reverse genetics system for making a genetically engineered Pichinde virus, and a collection of vectors that can be used to produce a genetically engineered Pichinde virus. Further provided are methods for using a reverse genetics system, and methods for producing an immune response in a subject.

Abstract: A recombinant protein and a preparation method and application thereof are provided. The recombinant protein includes a peptide, and the peptide includes an amino acid sequence after substitution of the sequence of SEQ ID NO: 1. The substitution includes at least one selected from the group consisting of the following substitutions: the amino acid at position 182 of SEQ ID NO: 1 is substituted with aspartic acid (Asp); the amino acid at position 268 of SEQ ID NO: 1 is substituted with aspartic acid (Asp); and the amino acid at position 384 of SEQ ID NO: 1 is substituted with tyrosine (Tyr). The recombinant protein is suitable for detecting glycated hemoglobin.

Abstract: A NADPH oxidase (Nox) protein includes a domain including 3 to 7 transmembrane helices, and an amino acid sequence including at least 2 bis-histidyl motifs, wherein each of the bis-histidyl motifs consists of 2 histidine residues separated by 12, 13 or 14 amino acid residues. The Nox protein may be produced by a method that includes solubilizing a solution of cells expressing the Nox protein using a detergent from the maltoside family to suspend the Nox protein in the solution.

Abstract: Provided are various novel DNA polymerases. Provided are: a DNA polymerase comprising: an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 12, which has a substitution of arginine at position 651 by an amino acid residue having a negatively charged side chain, preferably by asparatic acid or glutamic acid, more preferably by glutamic acid; and a DNA polymerase comprising an amino acid sequence modified from the amino acid sequence of SEQ ID NO: 14, which has a substitution of proline at position 653 by an amino acid residue having a negatively charged side chain, preferably by asparatic acid or glutamic acid, more preferably by glutamic acid.

Abstract: A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MC1 and a cytidine-specific recombinant RNase Cusativin.

Abstract: The invention provides a mutant enzyme having trans-sialidase activity (EC 3.2.1.18), characterized by an enhanced trans-sialidase:sialidase ratio when compared to its parent sialidase enzyme. Further the enzyme may be used in a method for trans-sialylating mono- and oligo-saccharides, including galacto-oligosaccharides (GOS), fructo-oligosaccharides (FOS), malto-oligosaccharides (MOS), isomalto-oligosaccarides (IMO), lactulose, melibiose, maltose, glycosyl sucrose, lactosucrose and fucose. Trans-sialidated mono- and oligo-saccharides, produced with the mutant enzyme, are useful in preparing infant formula, a prebiotic nutritional supplement, and a food supplement.

Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.

Abstract: The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Abstract: A protein construct including a gene encoding a light-sensitive protein fused to at least one of either a low complexity sequence, an intrinsically disordered protein region (IDR), or a repeating sequence of a linker and another gene encoding a light-sensitive protein. Among the many different possibilities contemplated, the protein construct may also advantageously include cleavage tags. This protein construct may be utilized for a variety of functions, including a method for protein purification, which requires introducing the protein construct into a living cell, and inducing the formation of clusters by irradiating the construct with light. The method may also advantageously include cleaving a target protein from an IDR, and separating the clusters via centrifuge. A kit for practicing in vivo aggregation or liquid-liquid phase separation is also included, the kit including the protein construct and a light source capable of producing a wavelength that the light-sensitive protein will respond to.

Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.

Abstract: A eukaryotic cell having xylose utilization ability. Provided is a protein that has xylose isomerase activity and has an amino acid sequence including, when aligned with an amino acid sequence expressed by SEQ ID NO:1, the 1st to 6th motifs expressed respectively by SEQ ID NOs:2 to 7 from the N-terminus side in the order described, and having, in place of asparagine (N) in an amino acid sequence of the 6th motif, another amino acid.

Abstract: A magnetic particle manipulation method for magnetic particle comprises the steps of; subjecting magnetic particles and a magnetic solid having a larger particle diameter than said magnetic particles to existing together in a liquid layer, and moving said magnetic solid and said magnetic particles in said liquid layer by a magnetic field manipulation. According to one aspect of the present invention; a manipulation method for magnetic particles comprising the steps of; moving magnetic particles in a first liquid layer into a gelled medium layer by a magnetic field manipulation in a device, wherein gelled medium layers and liquid layers are in-place alternately in a container, moving said magnetic particles present in the gelled medium into a second liquid layer by the magnetic field manipulation; and moving said magnetic particles along with said magnetic solid in the second liquid layer.

Abstract: The invention provides an oligonucleotide comprising an inosine, and/or a nucleotide containing a base able to form a wobble base pair or a functional equivalent thereof, wherein the oligonucleotide, or a functional equivalent thereof, comprises a sequence which is complementary to at least part of a dystrophin pre-m RNA exon or at least part of a non-exon region of a dystrophin pre-m RNA said part being a contiguous stretch comprising at least 8 nucleotides. The invention further provides the use of said oligonucleotide for preventing or treating DMD or BMD.

Abstract: The present invention relates to compositions and methods of use thereof for inhibiting mutant HTT mRNA transcription or CAG-expanded HTT protein expression in a cell, comprising contacting the cell with an effective amount of an oligomer targeting a differentiating polymorphism, wherein the differentiating polymorphism is selected from rs72239206, rs363107, rs362313, rs2530595, rs113407847. Specific oligomer sequences are also provided.

Abstract: Provided are a new precursor miRNA and the applications in tumor therapy thereof. The precursor miRNA, from 5?- to 3?-end thereof, has the structure represented by formula (I). B1 is an anti-miRNA and/or siRNA to be expressed; B2 is a sequence substantially or completely complementary to B1, and B2 is not complementary to C; C is a sequence with stem-loop structure; A1 and A2 are independently hydrogen or optionally a RNA sequence consisting of 4 to 5 bases. The precursor miRNA can be processed to form an anti-miRNA and/or siRNA in hosts.

Abstract: Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5? end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mRNA, are disclosed. The antisense compound is RNase-inactive, and is preferably a phosphorodiamidate-linked morpholino oligonucleotide. Such targeting is effective to inhibit natural mRNA splice processing, produce splice variant mRNAs, and inhibit normal expression of the protein.

Abstract: Disclosed are methods for modulating splicing of Ataxin 3 mRNA in an animal with modified oligonucleotides. Such compounds and methods are useful to treat, prevent, or ameliorate spinocerebellar ataxia type 3 (SCA3) in an individual in need thereof.

Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

Abstract: Long noncoding RNAs (lncRNAs) are identified that enhance pluripotency reprogramming of somatic cells as well as differentiation of pluripotent cells. Induced pluripotent stem (iPS) cell generation from somatic cells leads to the upregulation and downregulation of identified lncRNAs. The modulation of these lncRNAs are capable of enhancing pluripotency of somatic cells as well as enhancing differentiation of a pluripotent cell.

Abstract: Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and parkinsonism.

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

Abstract: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.

Abstract: The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.