Patents Issued in February 6, 2020
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Publication number: 20200038838Abstract: Disclosed are water-absorbent resin particles comprising a crosslinked polymer comprising a monomer unit derived from a water-soluble ethylenically unsaturated monomer, wherein an artificial menstrual blood volume increase rate as measured in an artificial menstrual blood swelling test conducted in the order of i), ii), and iii) is 70% or more. i) putting 1.0 g of water-absorbent resin particles into a measuring cylinder with an inner diameter of 27 mm. ii) injecting 10 ml of artificial menstrual blood into the cylinder at once to swell the water-absorbent resin particles. iii) measuring a volume (A) of the swollen water-absorbent resin particles after 60 seconds from the injection and calculating an artificial menstrual blood volume increase rate according to Equation (I) below. Artificial menstrual blood volume increase rate (%)=(A?B)/B×100 . . . (I), A . . . Volume (ml) of swollen water-absorbent resin particles, B . . . Volume (ml) of injected artificial menstrual blood.Type: ApplicationFiled: March 28, 2018Publication date: February 6, 2020Inventors: Hiroki YABUGUCHI, Hiromi MIYASHITA, Hideki YOKOYAMA
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Publication number: 20200038839Abstract: The present disclosure relates to a method of preparing a magnetic particle having a polymer matrix (P) and at least one magnetic core (M), preferably at least two magnetic cores (M), wherein the polymer matrix (P) comprises at least one hypercrosslinked polymer, wherein the method comprises (i) providing at least one magnetic core (M), preferably at least two magnetic cores (M), (ii) providing polymer precursor molecules, (iii) polymerizing the polymer precursor molecules according to (ii) in the presence of the at least one magnetic core (M), thereby forming a particle comprising the at least one magnetic core (M). Further, the present disclosure relates to particles obtained or obtainable by this method as well as to the use of these particles. In a further aspect, the disclosure relates to a method for determining at least one analyte in a fluid sample having the step of contacting of the magnetic particle with a fluid sample having or suspected of having the at least one analyte.Type: ApplicationFiled: October 11, 2019Publication date: February 6, 2020Applicant: Roche Diagnostics Operations, Inc.Inventors: Martin Eduardo Silvestre, Stephan Hug
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Publication number: 20200038840Abstract: Provided herein are photocatalytic carbon filters for the removal impurities such as microorganisms, organic compounds, algal toxins, and their degradation by-products from water and wastewater. The photolytic carbon filters comprise a porous titanium substrate comprising TiO2 nanotube arrays and multi-wall carbon nanotubes disposed on the TiO2 nanotube arrays. Also provided herein are methods of manufacture and methods of use of the disclosed photocatalytic carbon filters.Type: ApplicationFiled: December 19, 2017Publication date: February 6, 2020Inventors: Soryong Chae, Tahereh Noeiaghaei, Yoontaek OH
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Publication number: 20200038841Abstract: The present invention relates to a method of making a support material composition comprising an Mg/Al oxide, a cerium oxide and at least another rare earth element oxide, to a support material composition and to the use of the support material composition as a nitrogen oxide storage component within a catalyst for treating exhaust gases to reduce NOx content.Type: ApplicationFiled: May 3, 2018Publication date: February 6, 2020Inventors: Marcos Schoneborn, Dirk Niemeyer, Thomas Harmening, Sandra Fibikar
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Publication number: 20200038842Abstract: A metal compound-graphene oxide composite that can be used for manufacture of hydrogen. A composite has graphene oxide and at least one metal compound selected from cobalt compounds, nickel compounds, and molybdenum compounds. If the metal compound includes a cobalt compound or a nickel compound, in the infrared absorption spectrum of the complex, absorption derived from C—O groups is present and absorptions derived from O—H groups and C?O groups and absorption derived from bonds between graphene oxide and cobalt or nickel via oxygen atoms are essentially absent. If the metal compound is a molybdenum compound, in the infrared absorption spectrum of the complex, absorptions derived from C—O groups, O—H groups, and C?O groups, and absorption derived from bonds between graphene oxide and cobalt or nickel via oxygen atoms, are all essentially absent.Type: ApplicationFiled: October 5, 2017Publication date: February 6, 2020Inventors: Hideki HASHIMOTO, Kiyoshi ISOBE, Tomoko HORIBE, Yoshihiko SERA, Eiji YAMASHITA
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Publication number: 20200038843Abstract: Provided in this disclosure are catalyst compositions. The catalyst compositions include an oxidative dehydrogenation catalyst that includes a mixed metal oxide having the empirical formula: Mo1.0V0.12-0.49Te0.05-0.17Nb0.10-0.20AlcOd wherein c is from 0 to 2.0 and d is a number to satisfy the valence of the oxide. The compositions are at least 40 wt. % amorphous as measured by XRD. The disclosure also provides methods of making the compositions.Type: ApplicationFiled: August 1, 2019Publication date: February 6, 2020Applicant: NOVA Chemicals (International) S.A.Inventors: Vasily Simanzhenkov, Xiaoliang Gao, Marie Barnes, David Sullivan, Yoonhee Kim
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Publication number: 20200038844Abstract: The invention relates to potassium-promoted, Fe2+(Fe3+yAl3+1-y)2O4 [0.3?y?0.7] silica-containing extrudates, processes for the preparation of the extrudates with the aid of colloidal silica, and the use of the extrudates to catalyze processes for producing liquid hydrocarbons.Type: ApplicationFiled: October 8, 2019Publication date: February 6, 2020Applicant: B.G. Negev Technologies and Applications LTD., at Ben-Gurion UniversityInventors: Mordechay Herskowitz, Miron Landau, Roksana Vidruk, Meital Amouyal
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Publication number: 20200038845Abstract: A method for preparing an SCR catalyst may include: (1) placing a first aqueous solution containing a titanium oxide and a tungstate in an electric field environment, adjusting the pH value of the first aqueous solution, and adjusting the current direction of the electric field environment to obtain a first mixture; (2) providing a second mixture by, in the electric field environment, adding dropwise a second aqueous solution containing a soluble salt of one or more active components, a copper-organic polyamine complex and a dispersant to the first mixture, and adjusting the current direction; and (3) processing the second mixture to obtain the SCR catalyst. The one or more active components may be selected from Ce, Zr, Cu, Fe, Pr and Sc.Type: ApplicationFiled: July 17, 2019Publication date: February 6, 2020Applicants: BAOTOU RESEARCH INSTITUTE OF RARE EARTHS, NATIONAL ENGINEERING RESEARCH CENTRE OF RUIKE RARE EARTH METALLURGY AND FUNCTION MATERIALS CO., LTD., HEBEI HWAT AUTOMOBILE COMPONENTS CO., LTD.Inventors: Wenyi Zhao, Yan Wang, Zhaoqiang Li, Cheng Zhang, Rongrong Fan, Xin Guo, Yu Wang, Rong Wang, Lihua Song, Yanhai Song, Yuan Li, Zhiyong Ding, Jing Song
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Publication number: 20200038846Abstract: Described herein are catalysts relating to liquid synthesis, methods of their preparation, and methods of their use. In an embodiment according to the present disclosure, a method of producing a catalyst for liquid synthesis comprises: providing a silica oxide support; pretreating the silica oxide support to remove air and moisture; impregnating the pretreated silica oxide support with cobalt from a cobalt source using a cobalt impregnation method; and calcinating the impregnated silica oxide support in an oven with a temperature ramping profile, wherein the calcinating comprises feeding air into the oven.Type: ApplicationFiled: July 31, 2019Publication date: February 6, 2020Inventors: Frederick M. MacDonnell, Brian H. Dennis
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Publication number: 20200038847Abstract: Provided in this disclosure are oxidative dehydrogenation catalysts that include a mixed metal oxide having the empirical formula: Mo1.0V0.12-0.49Te0.05-0.17Nb0.10-0.20Od wherein d is a number to satisfy the valence of the oxide. The oxidative dehydrogenation catalyst is characterized by having XRD diffraction peaks (2? degrees) at 22±0.2, 27±0.2, 28.0±0.2, and 28.3±0.1. The disclosure also provides methods of making the catalysts that include wet ball milling.Type: ApplicationFiled: August 1, 2019Publication date: February 6, 2020Applicant: NOVA Chemicals (International) S.A.Inventors: Vasily Simanzhenkov, Xiaoliang Gao, Marie Barnes, David Sullivan, Yoonhee Kim, Perry de Wit
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Publication number: 20200038848Abstract: The present application provides a ZSM-35 molecular sieve and a preparation method thereof. The ZSM-35 molecular sieve is an aggregated ZSM-35 molecular sieve having a hierarchical macro-meso-microporous pore structure. Raw materials for the preparation method do not include an organic template agent and a crystal seed, and the preparation method includes the following steps: preparing a reactant gel where a molar ratio of SiO2, Al2O3, Na2O, K2O, oxygen-containing acid radical and H2O is (20-40):1.0:(1.5-2.0):(4.0-6.5):(1.0-4.0):(600-1200); sequentially performing an aging treatment and a crystallization treatment on the reactant gel, washing and drying a resulting synthetic product. The ZSM-35 molecular sieve provided by the present application may be obtained by synthesizing without using an organic template agent and crystal seed, and because it has a hierarchical pore structure, it is favorable for material diffusion and mass transfer.Type: ApplicationFiled: July 29, 2019Publication date: February 6, 2020Inventors: HAIYAN LIU, TAO ZHENG, ZHICHANG LIU, XIANGHAI MENG, RUI ZHANG, CHUNMING XU
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Publication number: 20200038849Abstract: A method of producing hydrothermally stable chabazite (CHA) zeolites is disclosed. The disclosed method is based on the use of reaction mixtures that (1) are essentially void of alkali metal cations and (2) contain the N,N,N-trimethyl-1-adamantyl ammonium (TMAda+) organic as the sole OSDA. The disclosed method results in a higher crystalline CHA zeolite that exhibits hydrothermal stability. There is also disclosed a zeolite material having a CHA-type framework structure made by the disclosed method. A method of selective catalytic reduction of NOx in exhaust gas using the material described herein is also disclosed.Type: ApplicationFiled: March 8, 2019Publication date: February 6, 2020Applicant: PQ CORPORATIONInventors: Joshua PACHECO, Bjorn MODEN
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Publication number: 20200038850Abstract: A composite material comprises a macroporous silicate-based material at least partially substituted with at least one microporous zeolite, wherein the microporous zeolite is functionalised with either copper, iron or both copper and iron, and wherein the composite material is in the form of particles. The composite material can be obtained using a method comprising the steps of: (i) providing a mixture comprising a silicate-containing scaffold having a macroporous structure, an aluminium source and an organic template; (ii) hydrothermally treating the mixture to form a microporous zeolite-containing structure substantially retaining the macroporous structure of the silicate-containing scaffold; (iii) incorporating copper, iron or both copper and iron into the zeolite. The cate-containing scaffold can be a diatomaceous earth.Type: ApplicationFiled: March 29, 2018Publication date: February 6, 2020Inventors: Juergen BAUER, Ralf DOTZEL, Joerg Werner MUENCH, Ralitsa PUROVA, Wilhelm SCHWIEGER, Thangaraj SELVAM, Ameen SHAHID
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Publication number: 20200038851Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, articles of manufacture comprising such compounds, and the use of such compounds in the metathesis of olefins and olefin compounds. The invention has utility in the fields of catalysts, organic synthesis, polymer chemistry, and industrial and fine chemicals industry.Type: ApplicationFiled: October 17, 2017Publication date: February 6, 2020Inventors: Adam M. JOHNS, Jessica R. HERRON, Richard L. PEDERSON, Bryan A. FIAMENGO, Jennifer A. BEERMAN, Tzu-Pin LIN, Crystal K. CHU, Robert H. GRUBBS
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Publication number: 20200038852Abstract: A method for producing an unsaturated hydrocarbon comprising: a dehydrogenation step of contacting a raw material gas containing at least one hydrocarbon selected from a group consisting of alkanes and olefins with a dehydrogenation catalyst containing a group 14 metal element and Pt to obtain a product gas containing at least one unsaturated hydrocarbon selected from the group consisting of olefins and conjugated dienes, and a regeneration step of contacting the dehydrogenation catalyst subjected to the dehydrogenation step with a regenerating gas containing molecular oxygen under a temperature condition of 310 to 450° C.Type: ApplicationFiled: December 27, 2017Publication date: February 6, 2020Applicant: JXTG Nippon Oil & Energy CorporationInventors: Nobuhiro KIMURA, Atsushi SEGAWA, Tatsuya ICHIJO
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Publication number: 20200038853Abstract: The invention relates to a sealed bag containing a reference fluid for the calibration or quality control of a sensor element for measuring body fluid parameters, the bag comprising peripheral walls of a first layered material. The bag further comprises an access port formed by an opening in the first layered material, wherein the opening is sealed by a cover of a second layered material, wherein the second layered material is more resistant to oxidation by the reference fluid than the first layered material.Type: ApplicationFiled: March 27, 2018Publication date: February 6, 2020Inventors: Torben RYDAL, Hans Peter Blaabjerg JAKOBSEN
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Publication number: 20200038854Abstract: It is an object of the present invention to provide a method or an immunochromatographic test piece, which controls a speed or a direction of development of a specimen on the immunochromatographic test piece, so that a treatment with an acid reagent, nitrite, and a neutralizing reagent is properly controlled.Type: ApplicationFiled: March 4, 2018Publication date: February 6, 2020Applicant: DENKA SEIKEN CO., LTD.Inventors: Daisuke KATO, Shino MURAMATSU, Tomohiro HATTORI
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Publication number: 20200038855Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.Type: ApplicationFiled: October 10, 2019Publication date: February 6, 2020Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Dafeng Chen, James E. Rasmussen, Manish Deshpande
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Publication number: 20200038856Abstract: This disclosure is directed to a device for manipulating a sample, such as a biological sample. A device of this disclosure includes mat having a top planar surface spaced apart from a bottom planar surface and a recess formedap in the top planar surface extending toward the bottom planar surface, the recess having an opening at the top planar surface and bounded by a non-planar bottom wall. By way of example, a device of this disclosure may be used to embed an aggregate of cells, such as an embryoid body or a neuralized embryoid body, within extracellular matrix.Type: ApplicationFiled: July 31, 2019Publication date: February 6, 2020Inventor: Leon Chew
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Publication number: 20200038857Abstract: A system for operating an electrokinetic device includes a support configured to hold and operatively couple with the electrokinetic device, an integrated electrical signal generation subsystem configured to apply a biasing voltage across a pair of electrodes in the electrokinetic device, and a light modulating subsystem configured to emit structured light onto the electrokinetic device. The system can further include a thermally controlled flow controller, and/or be configured to measure impedance across the electrokinetic device. The system can be a light microscope, including an optical train. The system can further include a light pipe, which can be part of the light modulating system, and which can be configured to supply light of substantially uniform intensity to the light modulating system or directly to the optical train.Type: ApplicationFiled: July 16, 2019Publication date: February 6, 2020Inventors: Andrew W. McFarland, Daniele Malleo, J. Tanner Nevill, Russell A. Newstrom, Keith J. Breinlinger, Paul M. Lundquist, Justin K. Valley, Jonathan Cloud Dragon Hubbard
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Publication number: 20200038858Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.Type: ApplicationFiled: October 11, 2019Publication date: February 6, 2020Inventors: Christoph Boehm, Sascha Lutz, Juergen Spinke
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Publication number: 20200038859Abstract: Provided herein is a method and device for partitioning a fluidic sample. The device contains a plate containing microwells. The method comprises depositing a sample on one or both of the plates when the plates are in an open configuration, wherein the deposition is in the form of a single or multiple droplet of the sample, wherein at least one of the droplets has a volume that occupies more than two microwells and closing the plates to the closed configuration to partition the sample in the microwells.Type: ApplicationFiled: February 8, 2018Publication date: February 6, 2020Applicant: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Yufan Zhang
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Publication number: 20200038860Abstract: A microreactor chip includes a substrate and a hydrophobic layer that is a layer provided on the substrate and made of a hydrophobic substance and is formed so that openings of a plurality of chambers are arranged regularly on a main surface of the layer. Each chamber is provided with a first lipid bilayer membrane and a second lipid bilayer membrane that are disposed with a gap therebetween in a depth direction so as to fractionate the chamber in the depth direction.Type: ApplicationFiled: March 2, 2018Publication date: February 6, 2020Applicant: THE UNIVERSITY OF TOKYOInventors: Rikiya WATANABE, Hiroyuki NOJI, Naoki SOGA
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Publication number: 20200038861Abstract: Provided herein are compositions, systems, and methods for high throughput screening. In particular, provided herein are microfluidic devices for high throughput analysis of multiplex chemical (e.g., drug interactions) across a wide range of concentrations.Type: ApplicationFiled: October 5, 2017Publication date: February 6, 2020Inventors: Euisik YOON, Zhixiong ZHANG, Yu-Chih CHEN
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Publication number: 20200038862Abstract: The invention relates to a fluidic system comprising a chamber which is closed by movable elements and which is connected to at least one channel. The entire system has at least one structured component, at least one component which is attached to the structured component, and a component for storing liquids. The invention additionally relates to a closure option for at least one fluidic interface. The closure option can be configured as a cap or a valve. The invention has at least two fluidic interfaces. The chamber is used such that the movable element can be moved into the chamber as well as out of the chamber by a movement of the movable element. Liquids or gases can be moved via one or more channels connected to the chamber by means of the movement and dispensed or received out of the structured component via a connection of the channel. A liquid reagent reservoir is connected to the pump chamber via the sample supply channel.Type: ApplicationFiled: November 16, 2017Publication date: February 6, 2020Inventors: Christian Moche, Richard Klemm, Claudia Gärtner
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Publication number: 20200038863Abstract: A microfluidic device with at least one integrated valve is provided for managing fluid flow in disposable assay devices, which provides constant flow even at very low flow rates. Pumps utilizing the microfluidic device, as well as methods for manufacture and performing a microfluidic process are also provided.Type: ApplicationFiled: October 8, 2019Publication date: February 6, 2020Inventors: Remus Brix A. Haupt, John Harald Holm Arvidsen
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Publication number: 20200038864Abstract: The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.Type: ApplicationFiled: October 9, 2019Publication date: February 6, 2020Inventors: Cameron Scott Ball, Ronald F. Renzi, Robert Meagher
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Publication number: 20200038865Abstract: A threaded fluidic fitting may include a fluid passage, at least one fluid port, a threaded fitting portion, an engageable body portion, and an electro-fluidic leak detection element. The fluid passage extends from the fluid port of the threaded fluidic fitting. The threaded fitting portion comprises a helical thread, extends from a leak detection face of the engageable body portion, and is configured to rotate with the engageable body portion to enhance a fluidically sealed engagement of one of the fluid ports with a complementary fluidic component. The electro-fluidic leak detection element is positioned on the leak detection face of the engageable body portion or on a drip edge portion of a face extending from the leak detection face. A fluid handling system may include a plurality of threaded fluidic fittings and a leak detecting computing hub in communication with the plurality of threaded fluidic fittings.Type: ApplicationFiled: July 31, 2019Publication date: February 6, 2020Applicant: Bio-Chem Fluidics, Inc.Inventors: Henry X Huang, Ethan Matthew Gardner, Razvan Bulugioiu, Michael Swern, William A Easterbrook, Sharad Harihar Joshi, Sr.
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Publication number: 20200038866Abstract: A system for and methods of analyzing a test sample through the use of a rotary apparatus that includes a microfluidic paper-based apparatus (mPAD). The apparatus includes two or more layers that are rotatable with respect to one another. A middle layer may comprise a microfluidic apparatus having one or more reagent channels. Each of the reagent channels may include reagent dried on the surface of the channel, and, together with an adsorption pad, may be aligned vertically with a sample chamber. Male and female engagement surfaces on each of the middle layer, the top layer, and the bottom layer interlock to secure each layers in vertical alignment so that fluid flows through the apparatus to contact a test sample with a reagent and facilitate detection of a target analyte in the test sample in the sample chamber.Type: ApplicationFiled: August 2, 2019Publication date: February 6, 2020Applicants: Colorado State University Research Foundation, United States Department of AgricultureInventors: Charles S. HENRY, Rachel FEENY, Alan B. FRANKLIN, Cody CARRELL
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Publication number: 20200038867Abstract: Method for handling at least one first microdrop and at least one second microdrop in a microfluidic system including a capillary trap that has a first trapping zone and a second trapping zone, the method including steps consisting of: (i) trapping the first microdrop in the first trapping zone, and (ii) trapping the second microdrop in the second trapping zone, the first and the second trapping zone being arranged such that the first and the second microdrops are in contact with each other, the first and the second trapping zones being adapted such that the trapping forces returned to one of the microdrops are different.Type: ApplicationFiled: September 29, 2017Publication date: February 6, 2020Applicants: ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Charles BAROUD, Raphaël TOMASI
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Publication number: 20200038868Abstract: An apparatus and method for performing analysis and identification of molecules have been presented. In one embodiment, a portable molecule analyzer includes a sample input/output connection to receive a sample, a nanopore-based sequencing chip to perform analysis on the sample substantially in real-time, and an output interface to output result of the analysis.Type: ApplicationFiled: October 2, 2017Publication date: February 6, 2020Applicant: Genvida Technology Company LimitedInventors: Daniel Wai-Cheong SO, Chi Yip HO
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Publication number: 20200038869Abstract: In an embodiment, a microfluidic chip includes a capillary is disposed between upper and lower substrates, where the capillary includes a porous monolithic structure disposed within the capillary, and a clamp structure is defined within the channel and engages with the capillary. The clamp structure comprises a thermoplastic material that, when heated to a selected temperature, deforms around the capillary to secure the capillary in alignment with the channel. In another embodiment, a microfluidic chip includes a porous monolithic brick disposed between first and second substrates, where each of the first and second substrates includes a channel extending through the substrate to the brick structure to provide a fluid flow path through the each of the first substrate, the second substrate and the brick structure.Type: ApplicationFiled: October 6, 2017Publication date: February 6, 2020Inventors: Donald Lad DeVoe, Jung Yeon Han
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Publication number: 20200038870Abstract: A microfluidic device for the isolation of particles of at least one specific type of a sample is described. The microfluidic device comprises: a first inlet adapted to receive a sample comprising the particles of the specific type, at least part of a separation group comprising a separation unit, which comprises a main chamber and a recovery chamber and being adapted to receive the sample and to transfer at least part of the particles of the specific type from the main chamber to the recovery chamber in a selective manner with respect to further particles of the sample, a first outlet which is designed to allow the particles of the specific type to be collected outside of the device and a second outlet adapted to allow at least a portion of the sample to flow out of the main chamber and out of the microfluidic device.Type: ApplicationFiled: October 18, 2017Publication date: February 6, 2020Inventors: Gianni Medoro, Alex Calanca, Nicolò Manaresi
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Publication number: 20200038871Abstract: The present invention relates to methods, devices, instruments, processes, and systems for the highly specific, targeted molecular analysis of regions of human genomes and transcriptomes from the blood, i.e. from cell free circulating DNA, exosomes, microRNA, IncRNA, circulating tumor cells, or total blood cells. The technology enables highly sensitive identification and enumeration of mutation, expression, copy number, translocation, alternative splicing, and methylation changes using spatial multiplexing and combined nuclease, ligation, polymerase, and sequencing reactions. Such technology may be used for non-invasive early detection of cancer, non-invasive cancer prognosis, and monitoring both treatment efficacy and disease recurrence of cancer.Type: ApplicationFiled: March 29, 2018Publication date: February 6, 2020Inventor: Francis BARANY
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Publication number: 20200038872Abstract: An apparatus includes a polymer base layer having a surface. A die that includes a fluid manipulation surface that is substantially coplanar with the surface of the polymer base layer. The die includes a control electrode to generate an electric field to perform microfluidic manipulation of fluid across the fluid manipulation surface of the die.Type: ApplicationFiled: April 21, 2017Publication date: February 6, 2020Applicant: Hewlett-Packard Development Company, L.P.Inventors: Michael W. Cumbie, Viktor SHKOLNIKOV, Chien-Hua CHEN
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Publication number: 20200038873Abstract: Disclosed is a device for packaging balls for reaction vessels for an analysis appliance, including: a body including at least one opening and used to house balls, a closing member, that can be moved relative to the body between a closed position in which the closing member closes the opening of the body, and an open position in which the opening of the body is open so as to allow the balls to be dispensed from the body.Type: ApplicationFiled: April 10, 2018Publication date: February 6, 2020Inventor: Matthieu BROSSARD
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Publication number: 20200038874Abstract: The present disclosure provides a reagent cartridge configured for use in an automated multi-module cell processing environment.Type: ApplicationFiled: October 9, 2019Publication date: February 6, 2020Inventors: Don Masquelier, Phillip Belgrader, Brian Van Hatten, Jorge Bernate, Bruce Chabansky
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Publication number: 20200038875Abstract: A shredding apparatus for separating scrap material includes a conveyor that delivers agglomerations of metal scrap from a collection area to a conveyor outlet where a shredding tool is positioned. The shredding tool is rotationally operable between a plurality of shredding speeds and includes teeth that shred the agglomerations of metal scrap for delivery to an outlet section. A variable speed motor rotationally operates the shredding tool to selectively define the plurality of shredding speeds. A sensor is positioned proximate one of the shredding tool and the conveyor. The sensor monitors a density of the agglomerations of metal scrap. A controller is in communication with the sensor and the motor. The sensor communicates the density of the agglomerations to the controller and the controller modulates an operational speed of the variable speed motor based upon the density of the agglomerations.Type: ApplicationFiled: August 2, 2018Publication date: February 6, 2020Inventor: Russell Dean Dudley
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Publication number: 20200038876Abstract: A system and method directed to the economical recovery of valuable iron constituents from iron blast furnace and steel-making slag fines wherein the slag is obtained and subjected to a series of classification steps which progressively sort the slag fines by various physical characteristics, including magnetism, size, and density, into relatively iron-rich and relatively iron-poor classifications, resulting in the isolation of iron-rich commercial byproduct at one or more of the classification steps.Type: ApplicationFiled: October 15, 2019Publication date: February 6, 2020Applicant: Fritz Enterprises, Inc.Inventors: Raymond C. FRITZ, Raymond J. FRITZ
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Publication number: 20200038877Abstract: There is provided a method of extracting material from a fluid method of extracting material from a fluid, the fluid being held within a fluid chamber. The method comprises drawing, with a magnetic field generating system, at least one magnetically susceptible member through the fluid around a closed path between at least three points in the chamber, said at least one member being adapted to bind to material in fluid in the chamber. The at least three points are arranged relative to each other in a shape having at least two dimensions, the magnetic field generating system being configured to move the at least on magnetically susceptible member directly between the at least three points, material in the fluid binding to the at least one magnetically susceptible member when it comes into contact with the at least one member as it moves through the fluid.Type: ApplicationFiled: October 13, 2017Publication date: February 6, 2020Inventors: Stuart Jackson, Stephen Peter Fitzgerald, Ivan McConnell, John Lamont
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Publication number: 20200038878Abstract: For the purpose of preparing and isolating diamagnetic nanoparticles, we add magnetic field into the preparation processes, so that impurities that can be attracted to a magnet will go to the magnetic source. This enables diamagnetic nanoparticles get purified and contain no such impurities, so that they will be pushed away from the magnetic source. Some preparation processes use evaporation and condensation to prepare nanoparticles. In such processes, we may control the temperature so that lower evaporating metals, such as bismuth, will evaporate, but higher evaporating metals, such as iron, will stay solid and retain a strong magnetism, so that, when we apply magnetic field, we can prepare bismuth nanoparticles that do not contain lower evaporating metals for the preparation process.Type: ApplicationFiled: August 4, 2019Publication date: February 6, 2020Inventors: Huanchen Li, Wendy Wang
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Publication number: 20200038879Abstract: An air vent system includes a conduit for airflow. A stream of air is moved through the conduit.Type: ApplicationFiled: August 2, 2018Publication date: February 6, 2020Inventor: Maxime SALANDRE
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Publication number: 20200038880Abstract: According to an example aspect of the present invention, there is provided a device for separating materials in the form of particles and/or drops from a gas flow, especially particles and/or drops the diameter of which varies from one nanometer to a few dozen nanometers, the device comprising an inlet for incoming air to be purified, a collection chamber, an outlet for the purified air, a voltage source with actuators, an fastening column to which ion yield tips have been coupled, the device is configured to direct high tension to the ion yield tips providing ion beams from the ion yield tips to the collection surface, the collection surface conducting electricity is electrically insulated from the outer wall of the collection chamber by an electrical insulation, and the device is configured to direct voltage of opposite sign to the ion yield tips than the voltage directed to the collection surface, wherein ion yield tips are arranged directly on a surface of the fastening column having a length, wherein theType: ApplicationFiled: October 11, 2019Publication date: February 6, 2020Inventors: Sampo Saari, Panu Karjalainen, Topi Rönkkö, Pasi Makkonen
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Publication number: 20200038881Abstract: A separation system is disclosed for separating selected particles from a mixture of particles in a fluid. The system includes a froth flotation vessel 10 into which in use the mixture of particles and fluid are subjected to an upward flow of an introduced gas to form a froth layer 13 which rises above an interface 14 formed between the froth layer 13 and the mixture of particles and fluid 12, such that a quantity of the selected particles is conveyed out of the vessel 10 by the froth layer 13 to become a first product of the system. The vessel 10 also has a first outlet 29 arranged in use for receiving a flow of some of the mixture of particles and fluid from the vessel 10, an entry to the first outlet 29 being located in a region proximate to, but below, the interface 14. The vessel also has a second outlet 20 arranged in use for receiving a flow of some of the mixture of particles and fluid from a region of the vessel 10 which is located below the first outlet 29.Type: ApplicationFiled: October 14, 2019Publication date: February 6, 2020Inventor: Graeme J. Jameson
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Publication number: 20200038882Abstract: A self-emptying separator includes a rotatable drum with an inlet, a liquid outlet, outlet openings for solid material, and a control system. A flowable starting product is cleared of the solids in continuous operation in a centrifugal field in the rotating drum. A continuous discharge of a clear phase is performed. A solid phase is discharged via the outlet openings from a solids collecting space of the drum into an annular solids catcher. The solids catcher has a device for generating a fluid curtain against which the solids, issuing from the outlet openings for solid material, impact.Type: ApplicationFiled: March 8, 2018Publication date: February 6, 2020Inventors: Tim HUNDERTMARK, Mario EMANUELE, Alexander PIEK, Jürgen MACKEL
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Publication number: 20200038883Abstract: Methods and systems for coating with shear and moisture sensitive materials are disclosed. A method of coating a product includes filling an inner bellows chamber of a bellows, which is provided within and isolated from an outer bellows chamber of a tank, with a predetermined amount of the coating material. The method of coating the product further includes supplying a pressurized material to the outer bellows chamber to pressurize the coating material within the inner bellows chamber to an operating pressure, and supplying the coating material within the inner bellows chamber to a spray gun at the operating pressure. The method of coating also includes determining that a measured actual pressure is within a predetermined control range of the target pressure and subsequently coating the product by spraying the product with the coating material from the spray gun.Type: ApplicationFiled: July 31, 2018Publication date: February 6, 2020Inventors: John Roos, Todd Frenk, Robert Sims, Benjamin S. Price
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Publication number: 20200038884Abstract: A fluidic component for generating a free jet includes a flow chamber that can be traversed by a fluid stream which enters the flow chamber through an inlet opening and exits from the flow chamber through an outlet opening and whose flow direction extends substantially parallel to the main direction of extension of the flow chamber. Within the flow chamber, a main flow channel and secondary flow channels are arranged. The cross-sectional profile of the main flow channel is divergent or sectionally divergent and sectionally convergent along the entire length of the main flow channel in the direction of the main direction of extension of the flow chamber.Type: ApplicationFiled: October 5, 2017Publication date: February 6, 2020Inventors: Jens Wintering, Bernhard Bobusch, Oliver Krüger
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Publication number: 20200038885Abstract: The invention discloses a water outlet device, which includes a shell part, a movable plate and a driving mechanism. The shell part is provided with a water outlet part.Type: ApplicationFiled: July 11, 2019Publication date: February 6, 2020Applicant: XIAMEN SOLEX HIGH-TECH INDUSTRIES CO., LTD.Inventors: Shilong WU, Fengde LIN, Wenxing CHEN, Qihua FAN
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Publication number: 20200038886Abstract: A handheld spray wand for showering, bathing, or the like. The spray wand including a fluid inlet and a nozzle portion in fluid communication with the fluid inlet. The nozzle portion including a first nozzle array extending along a longitudinal direction of the nozzle portion and a second nozzle array positioned adjacent to the first nozzle array and extending along the longitudinal direction of the nozzle portion. Within the nozzle arrays, the nozzles are staggered to define a staggered water pattern as water exits the nozzle portion.Type: ApplicationFiled: September 9, 2019Publication date: February 6, 2020Inventor: Jeffrey Thurgood
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Publication number: 20200038887Abstract: The present disclosure is related to a showerhead with a plurality of modes. The showerhead includes an engine defining a plurality of fluid channels or pathways. Two modes or mode apertures are in fluid communication with a first fluid channel, and another mode or mode aperture is in fluid communication with a second fluid channel. Additionally, the present disclosure is related to a method of producing a massaging spray mode for a showerhead. The method includes fluidly connecting a plurality of nozzles to a fluid source wherein each of the first plurality of nozzles are opened substantially simultaneously, and fluidly disconnecting the first plurality of nozzles from the fluid source wherein each of the nozzles within the first plurality of nozzles are closed substantially simultaneously.Type: ApplicationFiled: October 9, 2019Publication date: February 6, 2020Inventors: Joseph W. Cacka, Leland C. Leber, Michael J. Quinn