Abstract: Disclosed herein are human antibody molecules that immunospecifically bind to human CXCR2. The disclosed human antibody molecules are potent and selective antagonists of CXCR2 functions and prevent the recruitment of neutrophils into tissues without strongly depleting circulating neutrophil numbers. Pharmaceutical compositions, nucleic acid molecules, vectors, cells, and uses of the disclosed antibodies are also provided.

Abstract: The present disclosure provides novel anti-CD40 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of making and using the same.

Abstract: The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52. The present invention further relates to a humanized immunoglobulin light chain and a humanized immunoglobulin heavy chain. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a humanized immunoglobulin or immunoglobulin light chain or heavy chain, and to a method of preparing a humanized immunoglobulin. The humanized immunoglobulins can be used in therapeutic applications to treat, for example, autoimmune disease, cancer, non-Hodgkin's lymphoma, multiple sclerosis and chronic lymphocytic leukemia.

Abstract: The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.

Abstract: Disclosed herein are non-myeloablative antibody-toxin conjugates and compositions that target cell surface markers and related methods of their use to effectively conditioning a subject's tissues (e.g., bone marrow tissue) prior to engraftment or transplant. The compositions and methods disclosed herein may be used to condition a subject's tissues in advance of, for example, hematopoietic stem cell transplant and advantageously such compositions and methods do not cause the toxicities that are commonly associated with traditional conditioning methods.

Abstract: In various embodiments various cancer specific antibodies and immunoconjugates are provided. In certain embodiments the antibodies specifically bind and are internalized into a prostate cancer cell, where the antibodies specifically binds cells that express or overexpress a CD46, and where the antibodies specifically bind sushi domain 1 of said CD46 (CD46 CPP1).

Abstract: Provided herein are new compositions, methods, and devices to treat cancer through a combination of immunologic chemotherapeutic agents and ablation techniques. These compositions can include immune checkpoint inhibitors, cytokines and nucleic acid drugs that aid in eliciting an immune response to treat the tumor. The administration of these compositions in addition to various ablating techniques provides a presentation of the cancer cell antigens to the immune system and the immunologic targeting of the cancer.

Abstract: Chimeric antigen receptors that include an antigen recognition domain; a spacer domain derived from a modified immunoglobulin Fc region having one or more mutations in its CH2 region resulting in impaired binding to an FcR; and an intracellular signaling domain.

Abstract: Disclosed is a method for searching, identifying, or validating a marker CACNA2D1 of tumor-initiating cells. The method comprises a step of immunizing an animal using HEP-12 cells originating from a recurrent tumor and rich in originating cells. Also disclosed is a monoclonal antibody specially recognizing CACNA2D1 or antigen-binding fragments thereof, and the use thereof for treating or preventing tumors or diseases or conditions related to CACNA2D1.

Abstract: The present disclosure provides novel anti-PD-1 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of making and using the same.

Abstract: The present invention relates to a single chain binding molecule comprising at least three binding domains, wherein the first binding domain is capable of binding to serum albumin and is positioned at the N-terminus of the second binding domain, said second binding domain is capable of binding to a cell surface molecule on a target cell and the third binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention relates to methods for the production of such binding molecule, a nucleic acid sequence encoding it, a vector comprising said nucleic acid sequence and a host cell expressing the binding molecule of the invention. Furthermore, the invention relates to a pharmaceutical composition comprising a binding molecule of the invention, methods of treatment comprising the step of administering a binding molecule of the invention and the medical use of a binding molecule of the invention.

Abstract: The disclosure provides for a multimodal cancer therapy comprising chimeric viral/nonviral nanoparticles and anticancer agents and uses thereof to treat a subject with cancer or suspected of having a cancer.

Abstract: Described and provided herein are novel antibodies for Claudin 18.2. Also described and provided are pharmaceutical compositions of the antibodies and methods of use for the treatment of cancer.

Abstract: The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.

Abstract: The invention provides anti-KLK5 antibodies and methods of using the same.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: A hybridoma cell line of secreting meloxicam monoclonal antibodies with a preservation number of hybridoma cell line of CGMCC No. 14700 belongs to the field of food safety immunological detection. The. BALB/c mice are immunized through one time immunization with complete freund's adjuvant, three times of booster immunization with incomplete freund's adjuvant and one time of rush immunization with meroxicam complete antigen without adjuvant; the spleen cells from BALB/C mice immunized with high potency and low value of IC50 are fused with murine myeloma cells; and then the hybridoma cell line is obtained through indirect competitive ELISA screening and three sub-clones. The monoclonal antibody secreted by this cell line has good specificity and detection sensitivity to meloxicam (value of IC50 is 0.1 ng/ml), being suitable for detection of meroxicam in food.

Abstract: Disclosed is an antibody which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.

Abstract: A process for preparing a consumer product including a chemically modified polysaccharide, where the process includes the steps of combining a slurry including polysaccharide with a reactant to form a polysaccharide-reactant mixture, where the reactant includes an ester group; combining a base with the polysaccharide-reactant mixture to form a polysaccharide-reactant-base mixture; and allowing the polysaccharide-reactant-base mixture to form a transesterified polysaccharide mixture, where the transesterified polysaccharide mixture includes an alcohol.

Abstract: There is provided esterified starch which can be produced without using a non-aqueous organic solvent and has water resistance and miscibility with another plastic, and a starch-containing plastic composition. The esterified starch is obtained such that a starch mixture containing starch and a polyhydric alcohol, which is subjected to a heat treatment, is esterified with a vinyl ester and carbonate. Since the starch in the starch mixture enters a state in which starch granules are disintegrated by the polyhydric alcohol, by heating the starch mixture containing starch and a polyhydric alcohol, it is possible to esterify the starch without using a non-aqueous organic solvent and to obtain esterified starch having a high ester substitution degree. According to the esterified starch of the present invention, it is possible to obtain a starch-containing plastic composition having high hydrophobicity, and excellent water resistance and miscibility with another plastic.

Abstract: The present invention relates to a novel process for producing hemicellulose fractions from cereal crops, comprising pressurized hot water extraction of hemicellulose fractions from cereal crops in combination with subsequent enzymatic treatments and/or subsequent membrane ultrafiltration to further purify the extracts. The novel process described herein allows for sustainable and scalable extraction and isolation of valuable hemicellulose fractions, especially arabinoxylans (AXs), from cereal side products. The process allows the selective fractionation of arabinoxylans based on their molecular structure and inherent functionalities, which can e.g. be used for the preparation of carbohydrate-based materials with functional properties.

Abstract: A polymerization device that includes: a reaction vessel that houses a polymerization solution and in which a polymerization reaction is performed; a stirring blade that stirs the polymerization solution housed in the reaction vessel; a plurality of heat transfer pipes that transfer heat to the polymerization solution in order to start the polymerization reaction and cause the polymerization reaction to proceed, and that remove, from the polymerization solution, heat generated by the polymerization reaction; and a baffle arranged between a vessel wall of the reaction vessel and the heat transfer pipes.

Abstract: The invention relates to a compound of formula I the preparation thereof and the use thereof as monomer for the preparation of polymers.

Abstract: Provided herein are photopolymerizable monomers, optionally for use as reactive diluents in a high temperature lithography-based photopolymerization process, a method of producing polymers using said photopolymerizable monomers, the polymers thus produced, and orthodontic appliances comprising the polymers.

Abstract: Rotomolded polyethylene containers that are used to store sulfuric acid can become discolored on the interior surface which is in contact with the acid. This problem may be mitigated by the use of an additive package that contains two primary antioxidants.

Abstract: The present invention relates to a copolymer including 20 to 65 wt % of units derived from an alkyl styrene-based monomer; 10 to 40 wt % of units derived from a (meth)acrylate-based monomer; and 20 to 40 wt % of units derived from vinyl cyan-based monomer, based on the total weight of the copolymer, wherein the residual monomer content is 780 ppm or less, and a method for preparing the same.

Abstract: A material having a first non-zero elastic modulus capable of reversibly changing the first non-zero elastic modulus to a second non-zero elastic modulus in response to a redox reaction occurring in the material. A method of producing a material that is reversibly cyclable between a first non-zero elastic modulus and a second non-zero elastic modulus, comprising: preparing a polymer comprising both crosslinks that do not depend on metal binding and functional groups capable of having oxidation-state specific binding constants to a metal ion; and doping the polymer with a solution containing the metal ion.

Abstract: The purpose of the present invention is to provide a method for manufacturing a polymer having a desired strain. Provided is a method for manufacturing a polymer having a desired strain, said method comprising: a step for polymerizing one or more kinds of starting monomers by irradiating with ultraviolet rays having such an illuminance as to generate the desired strain; and, if required, a step for measuring the strain of the polymers thus formed and selecting a polymer having the desired strain. In one embodiment, provided is a method for determining the illuminance of ultraviolet rays for manufacturing a polymer having a desired strain.

Abstract: Provided is a carboxylic acid-modified nitrile-based copolymer latex, and more particularly, provided are a carboxylic acid-modified nitrile-based copolymer latex which includes a carboxylic acid-modified nitrile-based copolymer including a main monomer-derived repeating unit; and a repeating unit derived from a monomer represented by Chemical Formula 1 below, the main monomer-derived repeating unit including a conjugated diene-based monomer-derived repeating unit, an ethylenically unsaturated nitrile-based monomer-derived repeating unit, and an ethylenically unsaturated acid monomer-derived repeating unit (see description of the present invention), a method for preparing a carboxylic acid-modified nitrile-based copolymer latex, a latex composition for dip-forming including the copolymer latex, and an article formed by the composition.

Abstract: The present invention discloses a block copolymer comprising at least a block A and a block B, wherein the monomer of block A contains one or more of the structural units: a C3-C6 alkenyl group containing a substituent or a C3-C6 alkenyl group; wherein the number of R1 is 0, 1, 2, 3, 4 or 5; R2 is selected from the group consisting of: absent, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxyl, hydroxyl, halogen; “substituted” means a group is substituted by one or more substituents selected from halogen and hydroxyl; block B is obtained by polymerization of the monomer R6 is selected from F or a group containing F, and the number of R6 is 0, 1, 2, 3, 4 or 5. The block copolymer can assemble rapidly at a low temperature with self-repairing performance to reduce the defect rate.

Abstract: The invention relates to a novel type of sacrificial polymer or support material for 3D printing, comprising a block copolymer consisting of: at least one partially or totally hydrophilic elastomeric block, with a Tg of less than 30° C. and comprising at least one hydrophilic monomer, and at least one water-soluble thermoplastic block with a Tg of greater than 30° C. and comprising at least one monomer bearing a carboxyl group, said copolymer being extrudable and granulable, said copolymer being partially or totally soluble in water or in aqueous medium, and the mass proportion of the thermoplastic block being greater than 50% of the weight of said copolymer.

Abstract: A star block copolymer and a thermoplastic elastomer including plurality of the star block copolymers and a method of making both is taught. The star block copolymers of the present invention include a core component having an -methylstyrene oligomer wherein arms emanate from the core component and the arms are poly(isobutylene-block-styrene) diblock copolymers.

Abstract: The present application may provide a block copolymer and a use thereof. The present application may provide a block copolymer and a use thereof. The block copolymer of the present application may have excellent self-assembly properties or phase separation characteristics and simultaneously have characteristics capable of changing the self-assembly structure formed once, or provide a block copolymer capable of forming a pattern of phase separation structures in a polymer membrane.

Abstract: The present invention relates to specific translucent, preferably lightfast, polyurethane foams which have a high light transmission and are therefore suitable e.g. for producing translucent polyurethane foams or multilayer composite elements, for example for producing structural components, more particularly as roof elements such as strip lights and light domes, as wall elements such as a panel, in vehicles, in lamps, as furniture, as partitions and in sanitary facilities.

Abstract: The present invention provides a polyisocyanate composition and the like that contain a polyisocyanate compound represented by general formula (I), (II), (III) or (IV) (wherein the pluralities of R11, R21, R31 and R41 each independently represent an organic group, at least one of the pluralities of R11, R21, R31 and R41 is a group represented by general formula (V) (wherein each of the plurality of Y1 independently represents a single bond or the like, R51 represents a hydrogen atom or the like, and the wavy line indicates a bonding site) or the like, and in general formula (III), R32 represents a residue in which one hydroxyl group has been removed from a monohydric or higher alcohol).

Abstract: The present invention is a stretchable film of a cured product of a resin including: a polymer compound having a urethane bond in the main chain, a repeating unit containing a fluorine atom, and a repeating unit containing a silicon atom. The present invention provides a stretchable film that has excellent stretchability and strength, with the film surface having excellent water repellency, and a method for forming the same.

Abstract: A method for delivering antimicrobial compounds to a locus in a controlled manner by adding to the locus a compound having formula (I) wherein X is O or NH; R is an acrylic polymer, a saturated polyester, an alkyd resin, a polyether or a polycarbonate and R optionally has additional XC(O)NHCHR?R? substituents; R? is hydroxyl or NHC(O)XR; and R? is an organic substituent group having from one to twenty carbon atoms and which optionally has additional CHR?NHC(O)XR substituents.

Abstract: A graft macromer, comprising the reaction product of at least one macromer being at least one molecule which comprises in its structure one or more hydroxyl-terminated polyether and/or polyester chains, with at least one grafting compound which comprises in its structure at least one at least monoalkoxylated or at least monohalogenated silyl group and at least one alkyl, cycloalkyl or aryl containing group which is reactive towards the hydroxyl group of the macromer, is used for dispersing e.g. SiO2 in a polyol.

Abstract: The present invention relates to aliphatic, lightfast thermoplastic polyurethanes having improved blooming behaviour, good heat resistance and fast industrial processability, and the preparation and use thereof.

Abstract: A polymeric composition for restoring a previously formed spike hole in a wood railroad tie is described. The polymeric composition comprises a resin comprising a chain extender in a concentration of at least about 10 wt % and at least one polyol, and at least one isocyanate-containing compound. The chain extender may be diethylene glycol. The composition may also include a moisture control additive in a concentration of at least 5 wt % of the resin.

Abstract: Provided herein are curable compositions for use in a high temperature lithography-based photopolymerization process, a method of producing crosslinked polymers using said curable compositions, crosslinked polymers thus produced, and orthodontic appliances comprising the crosslinked polymers.

Abstract: An adhesive contains: (A) a monofunctional epoxy compound having one epoxy group per molecule; (B) a polyfunctional epoxy compound having two or more epoxy groups per molecule; (C) a photo cation generator; (D) an acrylic compound; (E) a photo-radical generator; and at least one compound selected from the group consisting of (F) a monofunctional oxetane compound and (H) a polyfunctional oxetane compound.

Abstract: A process for producing a low viscosity polyester polyol includes the steps of: (a) preparing a mixture which includes an aromatic diacid-based compound, an alkali metal ion-containing compound, and an aliphatic diol compound; and (b) subjecting the mixture to a reaction, wherein the alkali metal ion-containing compound has an alkali metal ion content of from 10 ppm to 12000 ppm based on a total weight of the mixture.

Abstract: [Problem] To provide a wholly aromatic liquid crystalline polyester resin having an excellent heat resistance and processability while having an extremely low dielectric tangent [Solving means] A wholly aromatic liquid crystalline polyester resin according to the present invention comprises, structural unit (I) derived from p-hydroxybenzoic acid, structural unit (II) derived from 6-hydroxy-2-naphthoic acid, structural unit (III) derived from an aromatic diol compound, structural unit (IV) derived from an aromatic dicarboxylic acid, wherein the composition ratio (mol %) of said structural units (I) to (IV) satisfies the following conditions: 2 mol %?structural unit (I)?9 mol % 40 mol %?structural unit (II)?75 mol % 9 mol %?structural unit (III)?24 mol % 9 mol %?structural unit (IV) 24 mol %.

Abstract: A solid-state polymerized poly(tetramethylene-2,5-furandicarboxylate) polymer is produced in a process including: providing a poly (tetramethylene-2,5-furandicarboxylate) polycondensate having a number average molecular weight (Mn) of at least 10,000, as determined by Gel Permeation Chromatography (GPC) using polystyrene as standard, and having a content of carboxylic acid end groups of at most 50 meq/kg; and keeping the poly(tetramethylene-2,5-furandicarboxylate) polycondensate at a temperature in the range of 80 to 140° C. to obtain a semi-crystalline polycondensate; and subjecting the semi-crystalline polycondensate to solid-state polymerization by keeping the semi-crystalline polycondensate at a temperature of at least 140° C. and below its melting point, whilst the semi-crystalline polycondensate is either under a flow of inert gas or under vacuum to obtain the solid-state polymerized poly(tetramethylene-2,5-furandicarboxylate) polymer.

Abstract: Provided is a polyphenylene ether resin composition whose mechanical properties are difficult to be changed through high temperature aging (e.g. 145° C.) while heat resistance and mechanical and electrical properties are maintained. When the bend elastic constant of the polyphenylene ether resin composition before aging measured in accordance with ISO-178 in an atmospheric air is taken as 100%, time required for the bend elastic constant to be 115% or more through aging in which the polyphenylene ether resin composition is left at rest at 150° C. is 2,000 hours or more; and a shaped article of 12.6 cm in length, 1.3 cm in width, and 1.6 mm in thickness formed from the polyphenylene ether resin composition exhibits a rate of change in chloroform-insoluble content of 15 mass % or less before and after aging in which the shaped article is left at rest for 1,000 hours at 150° C.

Abstract: Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.

Abstract: provided is a composition containing electron-donating polymer (D) having a structure represented by the following formula (1), and electron-withdrawing polymer (A) having a structure represented by the following formula (2): wherein definition of the symbols are as described in the DESCRIPTION.

Abstract: An addition-curable silicone resin composition which exhibits good adhesion to a substrate and has good compatibility with an inorganic filler, as well as a cured product thereof and a highly reliable semiconductor device encapsulated with the cured product, are provided. The addition-curable silicone resin composition includes (A) a linear or branched organopolysiloxane having at least one alkenyl group, said organopolysiloxane comprising at least one unit selected from R1R2SiO2/2 and R1R22SiO1/2 units, and at least one unit selected from R2?2SiO2/2, R2?3SiO1/2 and R2?SiO3/2 units, wherein a percentage of a total number of the R1R2SiO2/2 and R1R22SiO1/2 units, relative to a total number of all siloxane units, is from 0.