Abstract: The present invention provides a method for the production of a metal halide adduct of S4N4, in particular a specific copper adduct of S4N4, for the visualisation of a print on an object, in particular a fingerprint on a metal object. The present invention also provides a method and apparatus for visualising a print on an object, using S2N2 obtained from a metal halide adduct of S4N4.

Abstract: A medical system includes a probe, an electrooptical measurement unit, and a processor. The probe, which is configured for insertion into a blood vessel of a brain, includes one or more optical fibers configured to guide an optical signal to interact with a brain clot in the blood vessel, and to output the optical signal that interacted with the brain clot. The electrooptical measurement unit is configured to collect and measure the outputted optical signal. The processor is configured to identify a composition of the brain clot by analyzing the measured optical signal from the probe.

Abstract: An insulin device configured to control insulin dosage adapts a basal rate profile, using a sensor configured to produce a blood glucose level measurement data, and detect changes of the blood glucose level measurement data over time. A processor is configured to receive the blood glucose level measurement data and a basal rate profile. A basal rate set point corresponds to an insulin delivery reference for a nominal blood glucose. The insulin device includes an insulin dispensing valve controlled by the processor to administer insulin in accordance with the received basal rate profile. The processor is configured to update the basal rate set point over a time period based on both an assessment of at least one of a risk of hyperglycemia and a risk of hypoglycemia from historical blood glucose data, and patterns of actions taken by the insulin device to mitigate glycemic risk during the time period.

Abstract: A apparatus for estimating concentration may include: a spectrum obtainer configured to obtain Raman spectra of an object; and a processor configured to extract, from the Raman spectra, at least one analyte spectrum related to an analyte and at least one non-analyte spectrum related to a biological component other than the analyte, and estimate concentration of the analyte based on a first area under a curve of the at least one analyte spectrum and a second area under a curve of the at least one non-analyte spectrum.

Abstract: This disclosure concerns a medical sensor system comprising a sensor implantable under the skin of a user and an on-body module attachable to the skin in the region of the implantable sensor, wherein the on-body module has a self-adhering flexible electronics patch including a first transmitter which is operable to exchange data with the implantable sensor via a short-range wireless connection.

Abstract: An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery.

Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Abstract: Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject.

Abstract: A pulse oximetry device includes a light emission device configured to emit light with a wavelength in a first wavelength interval and light with a wavelength in a second wavelength interval, a first light detector configured to detect light with a wavelength in the first wavelength interval, but not to respond to light with a wavelength in the second wavelength interval, and a second light detector configured to detect light with a wavelength in the first wavelength interval and detect light with a wavelength in the second wavelength interval, wherein the light emission device has a first light-emitting diode structure configured to emit light with a wavelength in the first wavelength interval, and a second light-emitting diode structure configured to emit light with a wavelength in the second wavelength interval, and the first light-emitting diode structure and the second light-emitting diode structure are arranged in a common light-emitting diode chip.

Abstract: An arterial syringe assembly is disclosed. The assembly includes a housing with a proximal end that may couple with a syringe barrel and a distal end that may couple with a needle. A needle cover is coupled with the housing at a hinge that may rotate to position the needle cover relative to the needle and may rotate to an orientation aligned with the needle such that the needle is within the needle cover. A needle plug is coupled to the needle cover at a distal end of the needle cover and may include plug material. The needle plug may slide axially relative to the needle to advance the needle plug at a distal end of the needle. A hydrophobic filter is positioned within the syringe barrel to evacuate air through a proximal end of the syringe barrel after the needle tip extends within the plug material.

Abstract: A system for delivering learning programmes comprising optical sensors for capturing a subject's facial expression, eye movements, point-of-gaze, and head pose during a learning session; a data repository comprising task data entities; a module for estimating the subject's affective and cognitive states using the captured sensory data; and a module for selecting a task data entity for presentment to the subject after each completion of a task data entity based on a probability of the subject's understanding of the associated knowledge; wherein the probability of the subject's understanding is computed using the subject's estimated affective cognitive states.

Abstract: Embodiments of the invention provide devices and systems to monitor fullness of a patient's bladder. One embodiment of a bladder fullness (BF) measure system comprises a sensor device (SD) and a controller. The SD generates an output signal (OS) based on the force exerted by the bladder against SD the wherein the OS corresponds to a degree of BF. The SD may be attached to the bladder wall or adjoining tissue and positioned between the bladder and the pubic bone such that the SD is not affected by tissues force other than that from the bladder. The controller connects to the SD and causes an associated implant to perform a function when the SD output signal exceeds a predetermined threshold. Embodiments are particularly useful for providing information on BF to patients suffering from spinal injury or other conditions whereby they have lost the ability to sense BF and/or voluntarily urinate.

Abstract: A hydration and nutrition system includes a pressurized reservoir adapted to hold a quantity of fluid, a tube in fluid communication with the reservoir, a flow meter adapted to measure and collect flow data regarding the flow of fluid through the tube, one or more user performance sensors that provide performance data, and a database including a baseline requirements and a consumption plan. The baseline requirements are associated with a peak performance power output, and the consumption plan is based on a percentage of the baseline requirements for the peak performance power output. The system further includes a computerized nutritional calculator that performs the steps of receiving performance data, adjusting the consumption plan based on the performance data, calculating an actual caloric intake of fluid consumed, calculating a required caloric replenishment rate, and displaying a required caloric replenishment rate.

Abstract: Methods that can that can identify involuntary movement diseases are provided. One method includes sensing, by a set of sensors of a computing device, behavior of a user while the user interacts with the computing device and identifying, by a processor of the computing device, involuntary movement patterns for the user based on one or more characteristics of the sensed behavior. Systems and apparatus that can include, perform, and/or implement the methods are also provided.

Abstract: A treatment efficacy of a treatment for treating a parkinsonian disease is determined. A first set of imaging information/data associated with a dMRI scan of an individual's brain captured at a first time and a second set of imaging information/data associated with a dMRI scan of the individual's brain captured at a second time are received. The individual underwent the treatment for a time period comprising at least part of the time between the first and second times. An expected change between the first and second times is determined based on a natural progression of the parkinsonian disease. The first and second sets of imaging information/data are analyzed to determine a first free-water pattern and a second free-water pattern. Based on the first and second free-water patterns, a disease progression score is determined. Based on the disease progression score and the expected change, a treatment efficacy for treating the individual with the treatment is determined.

Abstract: A dementia information output system according to an aspect of the present invention includes: an acquisition unit configured to acquire an amount of body motion of a user; a determining unit configured to determine a likelihood that the user is developing a mild dementia or the like on the basis of a variability degree that is a degree by which an amount of body motion varies over a plurality of days in each of a plurality of time periods; and an outputting unit configured to output dementia information indicating the likelihood determined by the determining unit.

Abstract: An apparatus for determining a shape of a luminal sample including: a catheter including a lens, the catheter disposed within a strain-sensing sheath such that the lens rotates and translates; a structural imaging system optically coupled to the catheter; a strain-sensing system optically coupled to the catheter; and a controller coupled to the strain-sensing system and the structural imaging system. The controller determines: a first position of the catheter relative to the luminal sample at a first location within the strain-sensing sheath; a second position of the catheter relative to the luminal sample at a second location within the strain-sensing sheath; a first strain of the strain-sensing sheath at the first location; a second strain of the strain-sensing sheath at the second location; a local curvature of the luminal sample relative to the catheter; a local curvature of the catheter; and a local curvature of the luminal sample.

Abstract: A system (10) for evaluating a movement of a subject comprises: detection means (111, 112) for detecting a myoelectric signal indicating an activity of a muscle when a subject performs a movement intended to be a predetermined movement comprising a jaw movement, a tongue movement, or a throat movement; processing means (221) for outputting a processed myoelectric signal by applying predetermined processing on the detected myoelectric signal; and determination means (222) for determining a motion level in the predetermined movement of the subject, based on a pattern contained in the processed myoelectric signal.

Abstract: A computer-implemented method for supporting detection of a sign of cognitive decline is disclosed. In the method, a reference set of conversational data recorded for an individual and one or more sets of conversational data recorded for the individual on different days from the reference set are obtained. The method includes evaluating at least a temporal separation between conversations corresponding to the reference set and each of the one or more sets of the conversational data determine a value of the temporal separation. The method also includes determining topic similarity between the reference set and each of the one or more sets of the conversational data. A feature is generated for the individual based, at least in part, on relationship between the value and the topic similarity, and the computed feature is then sent as a message corresponding to a diagnosis.

Abstract: Systems to identify and risk stratify disease states, cardiac structural defects, functional cardiac deficiencies induced by teratogens and other toxic agents, pathological substrates, conduction delays and defects, and ejection fraction using single channel biological data obtained from the subject. A modified Matching Pursuit (MP) algorithm may be used to find a noiseless model of the data that is sparse and does not assume periodicity of the signal. After the model is derived, various metrics and subspaces are extracted to characterize the cardiac system. In another system, space-time domain is divided into a number of regions (which is largely determined by the signal length), the density of the signal is computed in each region and input to a learning algorithm to associate them to the desired cardiac dysfunction indicator target.

Abstract: Medical methods and systems relating to cardiovascular risk and/or performance assessment are provided. An individual performs a programmed activity of daily living such as reading displayed information aloud. The reading aloud is a temporary micro physiological challenge to the individual. The intensity of the micro challenges is gently increased over a short session. The cardiovascular (CV) response of the individual is measured during the session and is analyzed to assess a CV risk or performance of the individual. The existence of subtle CV deviations identified in the CV response of the individual may indicate a CV risk.

Abstract: A data processing apparatus and a data amount reducing method are disclosed. The data processing apparatus includes a receiving unit and a numerical transforming unit. The receiving unit is used to receive M original detection data, wherein M is a positive integer. The numerical transforming unit is coupled to the receiving unit and used to perform a numerical transforming process on the M original detection data to generate K numerical transformed data, wherein K is a positive integer smaller than M. Therefore, the amount of the K numerical transformed data can be smaller than the amount of the M original detection data to achieve the effect of reducing the amount of data.

Abstract: Devices and systems provide methods for detecting respiratory related effort from movements associated with the head or face. In one embodiment, a strain signal is measured by one or more sensors. A processor may analyze the head strain signal to detect respiratory related effort. Detection of effort may serve as a basis for identifying sleep disordered breathing events. For example, the analysis may serve as part of a detector to identify central or obstructive apneas or central or obstructive hypopneas. Sensors may be integrated with headgear to support them at desired locations of the face or head. Strain from head movement may be detected by measuring, for example, tension of the headgear or force applied against the headgear. The headgear may serve as an independent support for the sensors or as a component of a respiratory treatment apparatus, such as a mask or cannula.

Abstract: In order to increase the chances of acquiring biological information from a haired living organism, an electrode instrument includes: a belt configured to fit the electrode instrument to a living organism; a projection projecting from the belt; and an electrically conductive cloth disposed on a surface of the projection or in a vicinity thereof to function as a part of an electrode.

Abstract: Methods of measuring a physical or physiological parameter using an integrated adhesive sensor array including a sensor hub and a detachable sensor pod are presented. In one example, a method comprises: establishing a first communication link between the sensor hub and a wireless receiver; attaching at least the sensor hub directly to a body; establishing a second communication link between the detachable sensor pod and the sensor hub; sensing a physical or physiological parameter by the detachable sensor pod; transmitting sensor data of the physical or physiological parameter from the detachable sensor pod to the sensor hub via the second communication link; and transmitting the sensor data from the sensor hub to the wireless receiver via the first communication link.

Abstract: A device for detection of the tactile sensitivity of a user includes a base frame and a mechanical system joined to the base frame, the mechanical system being movable relative to the base frame and having a resting area for the fingertip of at least one finger of the user. The mechanical system includes a plurality of movable plate-shaped members arranged side by side to each other so that the resting area is defined by the thicknesses of at least part of the upper edges of the plate-shaped members. Each plate-shaped member is connected to an actuator, which can be operated to independently move each plate-shaped member from a minimum height position to a maximum height position, a control unit being further provided, which is adapted to operate the actuators.

Abstract: Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to release the active ingredient into an external environment based on the activation of the stimuli responsive actuator.

Abstract: Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to release the active ingredient into an external environment based on the activation of the stimuli responsive actuator.

Abstract: Elongated conductors are provided. Aspects of the elongated conductors include: an elongated structure having a proximal region and a distal region, where the elongated conductor includes two or more insulated conducting members that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region to the distal region. A pattern of insulation openings among the insulated conducting members is present at one or both of the proximal and distal regions. Aspects of the invention further include methods of making the elongated conductors, as well as devices that include the elongated conductors.

Abstract: An arm support assembly includes an armrest and connecting assembly. The armrest may meet regulatory or industry standards and is maneuverable into a variety of positions, including seated, blood pressure reading, supping or lying, and stowed or patient transfer positions. The armrest may be padded and/or upholstered. The connecting assembly includes first and second joints each selectively rotatable and an elongate member connecting them. The first joint rotatably mounts to the armrest, and the second joint mounts to the side of an examination device such as a table or chair. The joints include a rotary mechanism to engage between locked and unlocked positions, where rotational motion is enabled in unlocked positions. Rotation at first and second joints collectively result in maneuvering the armrest between the various positions.

Abstract: Methods and systems are provided for obtaining cleaned sequences showing trajectories of movement of a center of gravity and for estimating a biometric information pattern or value of a target. One of the methods includes removing noises from initial sequences showing trajectories of movement of a center of gravity to obtain the cleaned sequences. Another one of the methods includes reading cleaned sequences of the target into a memory, extracting features from the cleaned sequences, and estimating a biometric information pattern or value of the target from the extracted features, using a classification or regression model of biometric information patterns or values. The biometric information pattern may be a pattern derived from respiratory or circulatory organs of a target.

Abstract: An ECG signal lossless compression system includes: a signal difference value generating module and a compression module. The signal difference value generating module performs an adaptive linear prediction encoding on an ECG signal, so as to generate a plurality of signal difference values corresponding to each datum of the ECG signal;he compression module divides the signal difference values into a plurality of groups and performs an adaptive linear lossless compression encoding on each group, so as to generate a plurality of window compression streams, wherein each group corresponds to a bit reference index configured to be a compression encoding parameter of the adaptive linear lossless compression encoding.

Abstract: Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.

Abstract: The invention provides for a medical apparatus (100, 200, 300, 500) comprising an optical imaging system (106) configured for acquiring a series of optical images (544) descriptive of cardiac motion of a subject (102). The medical apparatus further comprises a memory (534) for storing machine executable instructions (540). The medical apparatus further comprises a processor (530) for controlling the medical apparatus. Execution of the machine executable instructions causes the processor to repeatedly: acquire (400) a series of images using the optical imaging system, wherein the series of images are acquired at a rate of at least 10 frames per second; and derive (402) a cardiac motion signal (546) from the series of images, wherein the cardiac motion signal is derived by tracking motion of at least a group of pixels within the series of images.

Abstract: A biological information measuring instrument performs high precision biological information measurement on a living body. The biological information measuring instrument includes: a measuring unit and an analysis unit that measure a user in a contactless manner to acquire biological information; and a speech unit that produces an alarm for reducing body movements of the user. The measuring unit and the analysis unit start to acquire biological information at an acquisition starting time. A control unit sets the acquisition starting time so as to fall in a prescribed range of time defined using an alarm starting time for the speech unit as a reference.

Abstract: The present disclosure relates to the field of medical monitoring, and, in particular, to non-contact detecting and monitoring of patient breathing. Systems, methods, and computer readable media are described for calculating a change in depth of regions in one or more regions of interest (ROI's) on a patient and assigning one or more visual indicators to the regions based on the calculated changes in depth of the regions over time. In some embodiments, one or more breathing parameter signals corresponding to the regions can be generated and/or analyzed. In these and other embodiments, the one or more visual indicators can be displayed overlaid onto the regions in real-time. In these and still other embodiments, the systems, methods, and/or computer readable media (i) can display one or more generated breathing parameter signals in real-time and/or (ii) can trigger an alert and/or an alarm when a breathing abnormality is detected.

Abstract: Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

Abstract: A storage unit 2 arranged on a foot side of a subject placed on a top board is provided with a box composed of a block member 22 and a plate member 23 and a lid 21 covering an upper side of the box. The lid 21 is provided so as to be capable of pivoting about a shaft 20 relative to the plate member 23 of the box composed of the block member 22 and the plate member 23. When the lid 21 is in a closed state, the upper portion of the plate member 23 of the box composed of the block member 22 and the plate member 23 is covered by the lid 21. In this state, as shown in FIG. 2, the upper surface of the lid 21 and the surface of the top board of the storage unit 2 are arranged at the same height, and are thus coplanar.

Abstract: In the field of radioimmunoguided surgical system instrumentation there is described and claimed a hand-held probe with a disposable power source as well as a visually perceptible indicator of detected counts of radiation. Also disclosed is a system comprising the hand-held probe and an instrumentation console. The handle includes a probe link that transmits a message containing gamma data relating to the low-level electrical signal. The instrumentation console may include a housing, a console link to receive the message transmitted by the probe link, a receiver electrically coupled to the console link to convert the message to corresponding electrical display signals, and a visually perceivable display electrically coupled to the receiver to convert the electrical display signals to a visually perceivable display relating to the amount of radiation detected.

Abstract: Among other things, an anti-scatter collimator is provided including a first layer defining a first retaining member at a first surface. A second layer defines a second retaining member at a first surface that faces the first surface of the first layer. A septum is disposed between the first layer and the second layer and physically contacts the first retaining member and the second retaining member. The first retaining member and the second retaining member maintain a position of the septum relative to the first layer and the second layer. The septum has a third attenuation coefficient that is greater than a first attenuation coefficient of the first layer and a second attenuation coefficient of the second layer. An end support is attached to the first layer and to the second layer. The end support borders an end of the septum.

Abstract: A method includes moving a radiation source and a radiation detector along a scan path substantially transverse to a longitudinal axis of a patient. A beam of radiation is emitted from the radiation source. The beam of radiation is detected at the radiation detector. The detected beam is processed so as to form a first image of a first area of the patient along the scan path.

Abstract: A method for improving the accuracy of a digital medical model of a part of a patient, the method includes obtaining a set of at least 2 medical images of the patient, where an element comprising a predefined geometry and/or predefined information was attached to the patient during the recording of the medical images; obtaining at least 2 tracking images taken with at least one camera having a known positional relationship relative to the medical imaging device, said tracking images depicting at least part of the element; determining any movement of the element between acquisition of the at least 2 tracking images; and generating the digital medical model from the acquired medical images, wherein the determined movement of the element is used to compensate for any movement of the patient between the acquisition of the medical images.

Abstract: Imaging systems and methods for imaging assisted interventional procedure that receive images of a region of interest, that automatically detect in the images a contrast agent puff as it courses through the region of interest, and that generate a display including a video replay loop of contrast enhanced images based on the automatic detection of the contrast agent puff.

Abstract: Synchronizing operation between a digital radiographic detector's integration periods and an x-ray generator's x-ray pulse rate by transmitting a frame rate to the detector and the generator. In a first mode, the detector monitors one or more pixels to detect an x-ray pulse. The firing time of the detected x-ray pulse relative to an internal clock of the detector is used to synchronize the detector's integration periods with the pulse rate of the x-ray generator based on the transmitted frame rate and the detected firing time of the x-ray pulses. Successive pulses may also be used to determine a frame rate without prior transmission thereof.

Abstract: A method for geometric calibration of a radiography apparatus acquires tomosynthesis projection images of patient anatomy from a detector and an x-ray source translated along a scan path. An epipolar geometry is calculated according to the relative position of the detector to the scan path by estimating a direction for epipolar lines that extend along an image plane that includes the detector. A region of interest of the patient anatomy that is a portion of each projection image and is fully included within each projection image in the series is defined. A consistency metric is calculated for estimated epipolar lines extending within the ROI. The method iteratively adjusts the epipolar line estimation until the consistency metric indicates accuracy to within a predetermined threshold. A portion of a tomosynthesis volume is reconstructed and displayed.

Abstract: Methods and implantable medical devices (IMDs) are provided for monitoring a cardiac function of a heart. A heart sound sensor is configured to sense heart sound signals of the subject. The IMD includes a memory to store program instructions. The IMD includes a processor that, when executing the program instructions, is configured to identify S2 signal segment from the heart sound signals, analyze the S2 signal segment to identify a pulmonary valve signal (P2 signal) and an aortic valve signal (A2 signal) within an S2 signal segment of the heart sound signals. The processor is configured to determine a time interval between the A2 and P2 signals, characterize the S2 signal segment to exhibit a first type of S2 split based on the time interval, and identify a cardiac condition based on a comparison of the first type of S2 split and a cardiac condition matrix.

Abstract: The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.

Abstract: Aspects of the technology described herein relate to ultrasound imaging of lungs. An ultrasound device may be configured with a set of parameter values associated with a shallow lung imaging mode. A selection of a change in imaging depth may be received. If the selected imaging depth is greater than or equal to a threshold imaging depth, the ultrasound device may be configured with a set of parameter values associated with a deep lung imaging mode. The set of parameter values associated with the shallow lung imaging mode may be optimized for imaging lung sliding and the set of parameter values associated with the deep lung imaging mode may be optimized for imaging A lines and B lines.

Abstract: A system and method for providing image guidance for placement of one or more medical devices at a target location. The system can be used to display portions of a display object, such as a rendered medical image, at different transparency levels. The system can also be used to resolve co-located display objects, such as a co-located image guidance cue and rendered medical image. The system can further be used to adjust a point-of-view location for one or more medical display objects within a virtual 3D space.