Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: An automatic retractable syringe comprised of a syringe inside a compressed spring loaded locking safety sheath that moves into a protective position over the needle of the syringe that is triggered by the depression of the plunger, causing the positional locking mechanism to displace from its initial position and activate a compressed spring that expands, moving the locking safety sheath into its protective position and locks the sheath, preventing further movement of the locking safety sheath. An optional fusing system acts to permanently fix the locking mechanism in place to further secure the locking safety sheath in the protective position.

Abstract: A system determines the location of a tip of a hypodermic needle by moving a needle along a path, shining light from two sources onto respective portions of the path, and analysing signals received from the respective light sources that have been reflected by the needle.

Abstract: The present invention relates to a medical device for intranasal delivery of a medicament. The medicament may be any type of medicament suitable for nasal administration and delivery in the form of a spray. The present invention ensures that a complete dosage of the medicament is delivered, especially to specific areas in the nasal cavity, such as the rear of the nasal cavity where the SPG is located.

Abstract: There is described a method for operating an inhalation chamber. A duct in the inhalation chamber extends from an opening for a source of gas to an opening for patient output, the duct comprising two portions, of which the shapes are complementary to form the duct, and displaceable in relation with each other. A MDI (or pMDI) and/or a nebulizer are connected to the inhalation chamber. A relative displacement is made between the two portions of the duct to close the duct and shunt the dead volume of the inhalation chamber, making a direct passage from the source of gas to the patient. If the nebulizer or the MDI is connected, a relative displacement is made between the two portions of the duct to open the duct to an inner volume of the inhalation chamber where the nebulizer or the MDI is dispensing aerosol. Other configurations are possible.

Abstract: A hand-held, portable inhalator device is disclosed. The device has a mouthpiece with a chamber operatively coupled to a medication inlet and a fluid outlet. A trigger is configured to dispense medication from a medication source through the medication inlet and into the chamber after a threshold level of positive pressure is achieved within the chamber of the mouthpiece and maintained for a threshold period of time.

Abstract: A breathing apparatus includes a control unit configured to control operation of the breathing apparatus based on at least a first input value and a second input value. The breathing apparatus also includes a graphical user interface connected to the control unit. The control unit is configured to display a visual output on the graphical user interface including an area defined by a first axis and a second axis. In addition, the breathing apparatus includes an input unit configured to provide selection of a portion of the area. The control unit is configured to set the first input value in response to the position of the selected portion relative the first axis and to set the second input value in response to the position of the selected portion relative the second axis.

Abstract: A respiratory flow therapy apparatus including a sensor module can measure a flow rate of gases or gases concentration provided to a patient. The sensor module can be located after a blower and/or mixer. The sensor module can include at least an ultrasonic transmitter, a receiver, a temperature sensor, a pressure sensor, a humidity sensor and/or a flow rate sensor. The receivers can be immersed in the gases flow path. The receivers can cancel delays in the transmitters and improve accuracy of measurements of characteristics of the gases flow. The receivers can allow for detection of a fault condition in a blower motor of the apparatus.

Abstract: An airway management device comprising a body having a proximal end for receiving an oxygen supply tube and an distal end for insertion into a trachea of a patient; said body including a linear portion adjacent to the proximal end and a curved portion adjacent to the distal end; said body including an external shell and having a first bore through said shell for receiving the oxygen supply tube; wherein flexural strength for said airway management device is provided by said shell.

Abstract: Certain embodiments are directed to a laryngoscopy device and methods of use thereof, the device having a curved, hollow stylet with a handle and a flexible bougie contained at least partially within the hollow stylet, the bougie being extendable out of the end of the stylet for use in guidance of a hollow endotracheal tube.

Abstract: A seal-forming structure for a patient interface may include a patient-contacting surface configured to engage the patient's facial skin to form a seal; a posterior opening formed in the patient-contacting surface, the posterior opening configured to provide the flow of air at said therapeutic pressure to the patient's nares; and a support structure extending from the patient contacting surface to an interior surface of the seal-forming structure, the support structure and the interior surface forming a continuous loop, wherein the patient interface is configured to allow the patient to breath from ambient through their mouth in the absence of a flow of pressurised air through the plenum chamber inlet port, or the patient interface is configured to leave the patient's mouth uncovered.

Abstract: This invention relates to a headgear component as a part of a headgear. The component comprising a backstrap, a first ear loop extending from one end of the backstrap, the first ear loop following a path defining a first ear opening, and a second ear loop extending from another end of the backstrap, the second ear loop following a path defining a second ear opening. A first pair of connection zones is on the first ear loop, each connection zone spaced an equal distance from the backstrap and spaced from each other, and a second pair of connection zones on the second ear loop, each connection zone spaced an equal distance apart from the backstrap and spaced from each other. A connection zone of the first pair and a connection zone of the second pair are on a first side of the backstrap, and a connection zone of the first pair and a connection zone of the second pair are on a second (other) side of the backstrap, wherein the headgear component is substantially of a symmetrical shape.

Abstract: This disclosure discloses a tracheal intubation device designed to improve safety during intubation attempts. The device allows for the delivery of medical gas (such as oxygen) flow through the endotracheal tube itself during intubation attempts. This moves the source of apneic oxygen lower in the patient's airway to bypass anatomy that otherwise can obstruct medical gas flow. The device can also switch on-demand to generating suction through the endotracheal tube to clear away fluids that block the intubator's view and that block medical gas flow. There are currently no devices that can deliver both medical gas and on-demand suction using the endotracheal tube as the flow conduit during the process of intubation. The present device accomplishes these tasks while incorporating non-obvious elements to optimize its use and efficacy.

Abstract: A humidifier uses a field of hydrophobic, nanotubes (e.g., vertically aligned carbon nanotubes) to humidify a gas. Voids in the field form liquid flow channels that are wide enough for liquid water to pass through. The nanotubes are spaced close enough to each other to prevent the water from escaping the channels. Water in the channels is absorbed by gas that flows and/or diffuses between the nanotubes. Humidity levels in the gas can be measured and controlled to a desired level by controlling the rate of flow of gas through the humidifier, controlling heating of the gas, and/or adjusting the total area of molecular transfer from the water to the gas by providing multiple banks of nanotubes and controlling the number of banks through which the gas flows.

Abstract: A sleeping machine includes sleeping machine comprising a housing, a base mounted on a lower portion of the housing, a top cover mounted on an upper portion of the housing, a main control module mounted in the housing, and an electromagnetic module mounted in the housing. The electromagnetic module is electrically connected with the main controller of the main control module. Thus, the electromagnetic module transmits electromagnetic waves with a specified frequency, so as to release and comfort the user, thereby helping the user sleep easily and comfortably.

Abstract: A filament platform insert for insertion into a bowl includes a plurality protruding stages and a plurality of recesses that are each formed in arcuate shapes to form a plurality of arcuate filament channels. An access channel extending along the platform insert, between a top and bottom, and between a rear and front, provides access for insertion of a finger or tool for manipulating an endovascular filament stored in the filament channel. The platform insert is dimensioned such that alignment of multiple such platforms will form filament raceways within a bowl for the coiled reception and storage of multiple endovascular filaments, with each filament reliably isolated from one another. In an alternative configuration, an endovascular filament bowl may be made to have the filament platform as a monolithic component thereof.

Abstract: Ureteral or bladder catheters are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion that includes one or more protected drainage holes, ports or perforations and is configured to establish an outer periphery or protective surface area that inhibits mucosal tissue from occluding the one or more protected drainage holes, ports or perforations upon application of negative pressure through the catheter. Systems, kits and methods for inducing negative pressure to increase renal function also are provided.

Abstract: The invention relates to a catheter device, having a catheter (1), an actuation device (8) at a first end of the catheter and also a mechanical transmission element (9, 10) for transmitting a movement along the catheter to the actuation device, the actuation device having a coupling element (14) which is connected to the transmission element (9, 10) and can be actuated by the latter relative to the longitudinal direction of the catheter in a first degree of freedom, and also a conversion element (15) which can be actuated by the coupling element and which converts the actuation movement at least partially into a movement in a second degree of freedom. As a result, a combined movement at the distal end of the catheter can be produced particularly simply for compression and release of a functional element.

Abstract: A guidance system for assisting with the insertion of a needle into a patient is disclosed. The guidance system utilizes ultrasound imaging or other suitable imaging technology. The guidance system can include an imaging device including a probe for producing an image of an internal body target, such as a vessel. One or more sensors can be included with the probe. The sensors sense a detectable characteristic related to the needle, such as a magnetic field of a magnet included with the needle. The system can include a processor that uses data relating to the sensed characteristic to determine a 3-D position of the needle, and a display for depicting the position of the needle. A needle assembly including a hub, cannula, and magnetic element is also disclosed, in which a magnetic axis of the magnetic element can be configured to be coaxially or otherwise aligned with the cannula axis.

Abstract: A medical instrument includes an expandable balloon, an intra-balloon deflection assembly, and one or more puller wires. The expandable balloon is coupled to a distal end of a shaft for insertion into a body of a patient. The intra-balloon deflection assembly is also coupled to the distal end of the shaft, and includes a distal section of the shaft which extends partially through the expandable balloon and includes (i) an elastic element coupled to a proximal side of the expandable balloon and configured to be bent relative to a longitudinal axis of the shaft, and (ii) a rigid element coupled to a distal side of the expandable balloon. The one or more puller wires are coupled to the rigid element and are configured to bend the elastic element, thereby deflecting the expandable balloon.

Abstract: An introducer includes a dilator received in a lumen defined by an introducer sheath and including a dilation end extending distally beyond a distal end of the introducer sheath. The introducer sheath includes a flat wire reinforcement having a hollow cylindrical shape sandwiched between an inner PTFE tube and an outer nylon tube. The outer nylon tube includes a distal segment that extends distally beyond the PTFE tube, which extends distally beyond the PTFE tube, which extends distally beyond the flat wire reinforcement. A withdrawal support wire has a distal end attached to a distal end turn of the flat wire reinforcement and extends in a proximal direction in parallel with a longitudinal axis between an outer surface of the nylon tube and an inner surface of the PTFE tube. The withdrawal support wire is configured to be in tension when the sheath is placed in tension to inhibit distal stretch separation breakage.

Abstract: An introducer sheath for the insertion of a medical device into a blood vessel having an expandable sheath. The sheath has a length, a thickness, and proximal and distal ends. The expandable sheath has a frame extending longitudinally between the proximal and the distal ends, and having an exterior surface and an interior surface that forms an interior lumen along the length of the frame. The frame is configured to achieve an expanded state and a contracted state, the expanded state forming an expanded cross-section in the lumen for passing a medical device therethrough. The frame has a smooth coating about the exterior surface and protrusions extending into the lumen along the interior surface. The introducer sheath can be introduced into a patient in the contracted state, with the distal end of the introducer sheath prevented from moving in the proximal direction by an abutment against a dilator end surface.

Abstract: An integrated guidewire includes a wire and a flexible tube. The wire is sized and shaped to move in an anatomical material transportation system of a patient. The flexible tube is sized and shaped to move in the anatomical material transportation system, having proximal and distal ends, the proximal-end is coupled to a device external to the patient, the flexible tube is configured to transfer fluids between the distal-end and the device, and the wire and the flexible tube are intertwined with respect to one another.

Abstract: Apparatus and methods for clearing obstructions from a medical tube are disclosed. In an exemplary embodiment, a spool drive system is disclosed for actuating a guide wire within a medical tube. The spool drive system can be a hand held, disposable device having a spool housing with a spool therein for alternately advancing and withdrawing a guide wire through an inlet of the spool housing. A track can be spaced from and extend about a perimeter of the spool to direct the guide wire onto or off of the spool as the spool is rotated. Other embodiments and devices for actuating the guide wire, and methods therefor, also are disclosed.

Abstract: A guide wire-catheter assembly includes a catheter tube having a longitudinal channel, and a guide wire configured to be movable in the longitudinal channel. The catheter tube includes a bendable part near its distal end. The bendable part includes, in the circumferential direction of the catheter tube, a varying flexibility, such that exerting a longitudinal compression force in a proximal direction at a compression location distally of the distal end part results in bending of the bendable part. The guide wire includes an expandable part, where the expandable part is movable between a non-expanded position, in which a cross section of the expandable part is smaller than a smallest cross section of the longitudinal channel of the catheter tube and an expanded position. When the expandable part is in the non-expanded position, the guide wire can be moved completely in and out of the longitudinal channel of the catheter tube.

Abstract: This patent document discloses perfusion catheters and related methods for treating blood vessel lesions and abnormalities. A perfusion catheter can include an inflatable balloon, an elongate shaft operably attached to the balloon, and an optional containment structure surrounding at least a portion of the balloon. The balloon can be inflated until its outer surface contacts a wall of a blood vessel. When inflated, the balloon's inner surface defines a passage for blood to flow. The balloon can be configured to release one or more substances formulated to treat a tissue at or near the wall of a blood vessel. In an example, the balloon can include a bioactive layer, which comprises the one or more substances, overlaying an optional base layer. In an example, the balloon can include multiple filars, at least one of which is configured to elute the one or more substances through a perforation or hole in the filar.

Abstract: A device for occluding a perforation in a blood vessel includes a catheter shaft that has a first lumen and a second lumen. The first lumen is adapted to receive at least one of a guidewire and an implanted cardiac lead, and the second lumen is adapted to receive an inflation fluid. The device further includes an inflatable balloon that is carried by the catheter shaft. The inflatable balloon is adapted to receive the inflation fluid from the second lumen, wherein the second lumen includes a cross-sectional area at a location within the catheter shaft between 0.65 mm2 and 1.90 mm2 and the inflatable balloon comprises polyurethane having a Shore A durometer of about 85 A.

Abstract: Devices and methods of treating fluid retention caused by congestive heart failure or other conditions resulting in edema, lymphoedema, or significant fluid retention (e.g., deep vein thrombosis, cellulitis, venous stasis insufficiency, or damage to the lymphatic network) are described. Specifically, a treatment device is used to create a passage or cannula between the lymphatic system (or other area of the body) and an external drainage device. This device can be only temporarily located in the patient or can be implanted within the patient for longer periods of time. The physician can safely and reliably remove excess fluid from the body via the device and optionally inject other treatment agents.

Abstract: The scope of the invention encompasses novel, multifunctional tools for maintaining the neovagina. The tools comprise novel dilator shapes that conform the anatomical pathway of the neovagina. The tools may further include a douching function for the effective and thorough washing of the neovagina, which is not achieved with standard douching devices. The tools may also comprise a measurement function for medical evaluation of the neovagina and to aid in proper dilation. Also presented herein are novel devices for delivery of agents to the natal vagina, including insemination devices.

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a patient can include a base layer, a plurality of microneedles projecting from the base layer, and a shell layer having an active ingredient. Each of the microneedles includes an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles can also include at least one dissolvable polymer. The active ingredient is incorporated in the shell layer, which extends around at least a portion of the elongate body.

Abstract: Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.

Abstract: Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery. Embodiments of the systems and methods can be used in combination with embolic protection systems including blood flow reversal mechanisms, arterial filters, and arterial occlusion devices.

Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.

Abstract: Presented herein are systems, methods, and devices that provide for stimulation of nerves and/or targets such as mechanoreceptors, tissue regions, mechanoresponsive proteins, and vascular targets through generation and delivery of mechanical vibrational waves. In certain embodiments, the approaches described herein utilize a stimulation device (e.g., a wearable device) for generation and delivery of the mechanical vibrational waves. As described herein, the delivered vibrational waves can be tailored based on particular targets (e.g., nerves, mechanoreceptors, vascular targets, tissue regions) to stimulate and/or to elicited particular desired responses in a subject.

Abstract: A method of generating an electric field in a target region of a patient includes inserting a set of electrodes having respective distal ends enclosed within a single elongate introducer shaft having a distal tip, into the vicinity of the target region; extending at least a pair of the electrodes to an extended position such that the electrode distal ends are deflected away from a longitudinal axis of the shaft in such a way that at least one planar projection taken in a plane perpendicular to the longitudinal axis of a distance between a pair of distal ends of the electrodes is larger than a maximal extent of a cross-section of the introducer shaft, the cross-section taken in a plane perpendicular to the a longitudinal axis at a distal end of the introducer shaft; and applying one or more electric pulses to the target tissue through the electrodes.

Abstract: Tissue-engineered nerve scaffolds, articles for up-selecting desired cell proliferation and down-selecting undesired cell proliferation, and methods of manufacturing the same are provided. The tissue-engineered nerve scaffold includes a hydrogel having a surface. The surface has a topography including a micropattern defined by a plurality of spaced features attached to or projected into the hydrogel. The micropattern facilitates attachment and alignment of neural cells and reduces attachment and alignment of cells associated with scar-tissue formation and encapsulation.

Abstract: The invention generally relates to methods for treating osteoarthritis. In certain embodiments, methods of the invention involve providing stimulation to a subject's central nervous system to modulate a signal sent to or from the subject's joint, thereby treating osteoarthritis.

Abstract: An apparatus associated with a cochlear implant system used by a patient directs a cochlear implant included within the cochlear implant system and implanted within the patient to generate electrical stimulation current at a predetermined current level. The apparatus further directs the cochlear implant to apply the electrical stimulation current to the patient by way of an electrode coupled with the cochlear implant, and to measure a voltage level associated with the electrode while the electrical stimulation current is applied to the patient by way of the electrode. Based on the predetermined current level and the measured voltage level, the apparatus determines an impedance of the electrode. Based on the determined electrode impedance and in accordance with a predetermined stimulation parameter adjustment constraint, the apparatus automatically adjusts a stimulation parameter associated with the cochlear implant system. Additional apparatuses and corresponding methods are also disclosed.

Abstract: Devices, systems, and methods may manage therapy delivery to a patient based on one or more physiological markers. In some examples, a method includes detecting a physiological marker that occurs prior in time to a dysfunctional phase of a physiological cycle, wherein a dysfunctional state of the physiological cycle occurs during the dysfunctional phase without treatment, responsive to detecting the physiological marker, initiating a first phase of the physiological cycle having a duration of time. The method may also include, responsive to the first phase elapsing, controlling a therapy delivery module to deliver neurostimulation therapy during a second phase that begins prior to the dysfunctional phase, wherein the neurostimulation therapy is configured to treat the dysfunctional state.

Abstract: The techniques of the disclosure describe example medical devices, systems, and methods for delivering stimulation therapy comprising a first set of a plurality of pulses having a first amplitude, and a second set of a plurality of pulses having a second amplitude greater than the first amplitude. The second amplitude is adjusted to an adjusted second amplitude based on second amplitude being less than or greater than activation threshold. The first amplitude is adjusted based on adjusted second amplitude, and therapy is delivered based at least one the adjusted first amplitude.

Abstract: Certain embodiments of the present technology disclosed herein relate to implantable systems, and methods for use therewith, that use a temperature sensor to initially detect an onset of patient activity, and then use a motion sensor to confirm or reject the initial detection of the onset of patient activity. Other embodiments of the present technology disclosed herein relate to implantable systems, and methods for use therewith, that use a motion sensor to initially detect an onset of patient activity, and then use a temperature sensor to confirm or reject the initial detection of the onset of patient activity. The use of both a motion sensor and a temperature sensor provides improvements over using just one of the types of sensors for rate responsive pacing.

Abstract: A hermetically sealed filtered feedthrough for an active implantable medical device includes a first conductive leadwire extending from a first end to a second end, the first leadwire second end extending outwardly beyond the device side of an insulator hermetically sealed to a ferrule for the feedthrough. A circuit board supporting a chip capacitor is disposed adjacent to a device side of the insulator and has a circuit board passageway. The first leadwire first end resides in the circuit board passageway. A second conductive leadwire on the device side has a second leadwire first end disposed in the circuit board passageway with a second leadwire second end extending outwardly beyond the circuit board to be connectable to AIMD internal electronics. The second leadwire first end is connected to the first leadwire first end and a capacitor internal metallization in the circuit board passageway.

Abstract: The present disclosure provides improved leadless pacemakers. In one embodiment, the leadless pacemaker includes an implantable pulse generator releasably coupled to a collapsible anchoring device. The collapsible anchoring device includes at least one pacing electrode configured to contact tissue at a target site.

Abstract: A leafless biostimulator, such as a leadless pacemaker, includes a housing sized and configured to be implanted within a heart of a patient and includes both primary and secondary fixation features. The primary fixation feature is adapted to rotate to fix the leadless biostimulator to a wall of the heart during initial implantation. Once the leadless biostimulator is implanted, the secondary fixation feature is adapted to resist counter-rotation of the leadless biostimulator. The primary fixation feature may include a fixation helix configured to affix the housing to the heart by rotating in a screwing direction. The secondary fixation feature may include an apex to engage the heart to resist unscrewing of the primary fixation feature.

Abstract: A smart carry case which is effectively a portable GPS-enabled, AED monitoring system that is capable of monitoring an AED (as well as itself) and reporting back the presence, function and location of the AED to a remote host. Also disclosed is street furniture that is configured to retain, continuously monitor, and dispense an AED and communicate to a remote host (i.e., a control room). The street furniture is preferably configured such that a user presses the intercom button. In response, the street furniture contacts the control room. The control room, in turn, sends a signal to the street furniture causing the compartment to unlock so the AED can be removed and used in a rescue. The street furniture is configured to continuously monitor the AED and ensure it is functional, using a device such as has been described hereinabove. If the AED is used, an ambulance is deployed to the location. The AED that is retained in the compartment may be a smart carry case.

Abstract: A smart carry case which is effectively a portable GPS-enabled, AED monitoring system that is capable of monitoring an AED (as well as itself) and reporting back the presence, function and location of the AED to a remote host. Also disclosed is street furniture that is configured to retain, continuously monitor, and dispense an AED and communicate to a remote host (i.e., a control room). The street furniture is preferably configured such that a user presses the intercom button. In response, the street furniture contacts the control room. The control room, in turn, sends a signal to the street furniture causing the compartment to unlock so the AED can be removed and used in a rescue. The street furniture is configured to continuously monitor the AED and ensure it is functional, using a device such as has been described hereinabove. If the AED is used, an ambulance is deployed to the location. The AED that is retained in the compartment may be a smart carry case.

Abstract: Apparatus and methods are described for use with a heating device (26) configured to heat at least a portion of a subject's body. A nanoparticle (22) is configured to be administered to the subject, the nanoparticle including at least one inner core (30) that includes a magnetic material having a Curie temperature; a phase-change-material layer (31) that surrounds the inner core and that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change selected from the group consisting of: solid to liquid, and gel to liquid, the phase-change occurring at a phase-change temperature that is lower than the Curie temperature; and an outer layer (32) disposed around the phase-change-material layer, the outer layer comprising a plurality of nano-subparticles (34) that are separated from one another, such as to form a segmented layer. Other applications are also described.

Abstract: The present invention classifies disorders, including Local Anesthetic Responsive Headaches as a general class. The present invention also uses exclusion and inclusion criteria in order to better determine the proper treatment of disorders including dorsonasal targeted therapies.

Abstract: A method for machine learning based artifact rejection is provided. The method may include applying a machine learning model to identify artefactual independent components in transcranial magnetic stimulation electroencephalogram data collected during a transcranial magnetic stimulation procedure. Clean transcranial magnetic stimulation electroencephalogram data is generated by removing, from the transcranial magnetic stimulation electroencephalogram data, the artefactual independent components. Real-time adjustments to parameters of the transcranial magnetic stimulation procedure may be performed based on the clean transcranial magnetic stimulation electroencephalogram data. Related systems and articles of manufacture, including computer program products, are also provided.

Abstract: Neural stimulator systems with an external magnetic coil to produce changing magnetic fields is applied outside the body, in conjunction with one or more tiny injectable objects that concentrates the induced electric field to a highly-targeted location. These systems include a driver circuit for the magnetic coil that allows for high voltage and fast pulses in the coil, while requiring low-voltage power supply that may be powered by a wearable or portable external device, along with the coil and driver circuit.