Abstract: It is an object to provide effective means for preventing and/or treating fulminant acute pneumonia. Provided are a pharmaceutical agent or pharmaceutical composition to be used for preventing and/or treating fulminant acute pneumonia, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing intra-alveolar neutrophil aggregation, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing pulmonary neutrophil infiltration, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), and a method of preventing and/or treating fulminant acute pneumonia, including administering a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody).

Abstract: The present invention relates to polypeptides comprising a mutant human IgG4, which mutant human IgG4 is capable of increasing the binding to and activation of immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing Fc?RIIb/c (CD32b), but not Fc?RIIa (CD32a). More specifically, the invention relates to polypeptides comprising at least one human IgG4 with a lysine at position 409 (409K), using the EU index according to Kabat et al., which IgG4 is capable of binding to human CD32b/c with a statistically significant (p=0.05) higher binding affinity than a wild-type human IgG1 and than a wild-type human IgG4, for use in the prevention and/or treatment of an autoimmune disease or allergy, as further defined in the claims.

Abstract: The present invention relates to the treatment or prevention of P-selectin mediated disorders, and to anti-P-selectin antibodies or binding fragments thereof, for use in the treatment or prevention of such disorders. In particular, the invention relates to the treatment or prevention of pain crises associated with sickle cell disease, and to anti-P-selectin antibodies or binding fragments thereof, for use in the treatment or prevention of pain crises associated with sickle cell disease.

Abstract: A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a ?c receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the ?c common chain to thereby reduce the IL-4 and/or IL-13 levels.

Abstract: The invention provides anti-IFNAR1 antibodies with reduced affinity for Fc receptors and/or ligands and methods of making and using such antibodies.

Abstract: Provided by the disclosure are compositions and methods for modulating differentiation of regulatory T cells. In some embodiments, methods include selectively decreasing IL-23R activity and/or IL-23R expression without significantly decreasing IL-12RP activity and/or IL-12RP expression.

Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.

Abstract: The present invention provides various compositions and methods useful for the treatment of cancer, including, but not limited to, cancers that are resistant to immune checkpoint blockade and/or are resistant to treatment with PD-1, PD-L1 or CTLA-4 inhibitors. In some embodiments the present invention provides compositions comprising “bi-specific activators”—which are nanoparticles having both a CD40 agonist antibody and an antibody specific for a tumor-associated antigen on their surface. In some embodiments such nanoparticles comprise one or more vaccine adjuvants, for example inside the nanoparticles. The present invention also relates to the use of such compositions in the treatment of tumors.

Abstract: The invention relates to the treatment of diseases associated with expression of BCMA, in particular myelomas. The invention relates to combination therapies of a BCMA CAR-expressing cell and a gamma secretase inhibitor.

Abstract: This invention relates generally to bifunctional molecules including (a) a TGF?RII or fragment thereof capable of binding TGF? and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as Programmed Death Ligand 1 (PD-L1), uses of such molecules (e.g., for treating cancer), and methods of making such molecules.

Abstract: An is provided for inhibiting the dissimilar expression of a PIWIL2 gene and a protein antibody against the dissimilar expression of the PIWIL2 gene in preparation of an anti-tumor drug. It has been experimentally proved that, treating human or mouse tumor cells with KAO3 upon inoculation can effectively inhibit the tumorigenesis in a mouse. Furthermore, injecting KAO3 into established lymphoma, breast cancer, lung cancer and cervical cancer can significantly inhibit tumor growth and prolong the survival of a tumor-bearing mouse. The inhibitory effect of KAO3 is associated with KAO3-specific antigens expressed on the surface of a tumor cell. KAO3 induces apoptosis of the tumor cell by blocking the cell cycle in a G2/M phase, inhibiting DNA synthesis and activating a complement. Therefore, the anti-PL2L60 mAb (KAO3) is a potential therapeutic candidate drug for treating a cancer.

Abstract: The present invention relates to an antibody specifically binding to a pancreatic adenocarcinoma upregulated factor (PAUF) protein and use thereof. The antibody of the present invention binds to a PAUF protein with high specificity and affinity and thereby inhibits the proliferation, migration, invasion, and in vivo growth, and thus the antibody of the present invention can be effectively used in the field of diagnosis and treatment of diseases such as cancer in which PAUF proteins are overexpressed.

Abstract: The invention relates to antibodies against carcinoembryonic antigen (CEA) which have a direct cell growth inhibition activity on tumor cells expressing CEA and to their use for the treatment and diagnosis of cancer.

Abstract: Preparations and methods for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2), and wherein one or more treatment periods with the antibody may be preceded, accompanied, and/or followed by one or more treatment periods with a retinoid.

Abstract: Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.

Abstract: Provided herein are anti-FGL2 monoclonal antibodies. Further provided herein are methods to reverse suppressive immune mechanisms, such as for the treatment of cancer or infectious diseases.

Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.

Abstract: A method of treating sarcopenia comprises administering to a subject a composition comprising an anti-AGE antibody. The method may also be used for preventing or delaying the onset of cataracts, preventing or delaying the onset of loss of adipose tissue, increasing health span, and preventing or delaying the onset of lordokyphosis.

Abstract: The present invention provides a bi-functional fusion protein, (AT)a-Fc-(VT)b, simultaneously targeting vascular endothelial growth factor (VEGF) and angiopoietins (ANGs), wherein AT is an ANG binding motif; and VT is a VEGF binding motif, Fc is an N-terminal of IgG; each of a and b is an integer from 1 to 10. The bi-functional fusion proteins contain two or more domains of human proteins and are of all human sequences, and thus are expected to be non-immunogenic, and potentially can be used therapeutically in human targeting angiogenesis-associated diseases.

Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, nindependently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V1 and V2, in particular where a disulphide bond is present.

Abstract: Regioselectively substituted cellulose esters having a plurality of aryl-acyl substituents and a plurality of alkyl-acyl substituents are disclosed along with methods for making the same. Such cellulose esters may be suitable for use in optical films, such as optical films having certain Nz values, ?A optical films, and/or +C optical films. Optical films prepared employing such cellulose esters have a variety of commercial applications, such as, for example, as compensation films in liquid crystal displays and/or waveplates in creating circular polarized light used in 3-D technology.

Abstract: A method for preparing oxidized cellulose, oxidized cellulose, an application of oxidized cellulose in manufacturing a detergent, and a detergent. The method comprises: preforming extraction on a corncob to obtain cellulose; preparing the cellulose into a cellulose solution; and performing TEMPO oxidation on the cellulose solution to obtain oxidized cellulose.

Abstract: The present invention provides a method for removing a divalent metal cation from a macromolecular compound having an anionic functional group and containing the divalent metal cation, including (1) suspending a macromolecular compound having an anionic functional group and containing a divalent metal cation in a solution in which an electrolyte that releases an alkali metal ion is dissolved at a concentration at which the macromolecular compound is salted out, and (2) performing, in the obtained suspension, an ion exchange reaction to exchange the divalent metal cation contained in the macromolecular compound with the alkali metal ion.

Abstract: A rubber composition for a tire is disclosed having improved rupture strength and abrasion resistance while maintaining processability that is a property of a liquid rubber. The rubber component contains (A) a hydrogenated copolymer obtained by hydrogenating an aromatic vinyl-conjugated diene copolymer, the hydrogenated copolymer having a weight average molecular weight measured by gel permeation chromatography of 300,000 or more and having a hydrogenation ratio of a conjugated diene moiety of 80 mol % or more, and (B) a liquid rubber, and sulfur, wherein the content of the hydrogenated copolymer (A) is 80 to 95 parts by mass and the content of the liquid rubber (B) is 5 to 20 parts by mass, per 100 parts by mass of the rubber component, and the content of the sulfur is 15 to 30 parts by mass per 100 parts by mass of the liquid rubber (B).

Abstract: A rubber composition for a tire that can improve processability and wet grip performance while maintaining rupture strength that is a property of a hydrogenated copolymer, and a pneumatic tire using the same, are disclosed. A rubber composition for a tire comprising a rubber component containing a hydrogenated copolymer obtained by hydrogenating an aromatic vinyl-conjugated diene copolymer, the hydrogenated copolymer having a weight average molecular weight measured by gel permeation chromatography of 300,000 or more and having a hydrogenation ratio of a conjugated diene moiety of 80 mol % or more, and a resin having a softening point of 60° C. or higher, wherein the resin is at least one selected from the group consisting of a petroleum resin, a phenolic resin, a rosin resin and a terpene resin.

Abstract: A continuous process for manufacturing macroporous beads, the process comprising: providing an aqueous carrier phase flowing through a pipe at a carrier phase flow velocity; providing an emulsion of a UV-polymerisable or thermally polymerisable continuous phase in an aqueous dispersed phase; injecting the emulsion into the carrier phase at an injection speed to create polymerisable droplets flowing in the carrier phase; forming macroporous beads by irradiating the droplets with UV light, or by heating the droplets to a temperature sufficient to decompose a thermal initiator in the continuous phase, to polymerise the droplets; and removing the macroporous beads from the carrier phase; wherein the ratio of carrier phase flow velocity/injection speed is at least 1.

Abstract: Embodiments of an invention disclosed herein relate to a process for adjusting one or more of the high load melt index (I21.6), weight average molecular weight (Mw), and molecular weight distribution (Mw/Mn) of one or more of polyolefin polymers during a polymerization reaction or adjusting the catalyst activity of the polymerization reaction, the process includes a) pre-contacting at least one chromium-containing catalyst with at least one aluminum alkyl to form a catalyst mixture outside of a polymerization reactor; b) passing the catalyst mixture to the polymerization reactor; c) contacting the catalyst mixture with one or more monomers under polymerizable conditions to form the one or more of polyolefin polymers; and d) recovering the one or more of polyolefin polymers.

Abstract: Systems and methods for Atom Transfer Radical Polymerization (ATRP) emulsion polymerization are provided. The ATRP emulsion polymerization comprises a suspending medium, a dispersed medium, a surfactant, a transition metal compound in a higher oxidation state, a ligand, and an ATRP initiator. The transition metal compound is capable of forming a catalyst complex in a presence of the ligand. The catalyst complex is soluble in the suspending medium and is capable of forming an ionic complex with the surfactant. The ionic complex is capable of moving between the suspending medium and the dispersed medium. A portion of the transition metal compound in the higher oxidation state within a portion of the catalyst complex is reduced by a physical and/or a chemical procedure thereby initiating a polymerization of one or more radically (co)polymerizable monomers by reaction with the initiator.

Abstract: The present invention relates to a process for the preparation of a procatalyst suitable for preparing a catalyst composition for olefin polymerization, said process comprising the steps of: Step A) providing or preparing a Grignard compound; Step B) contacting the Grignard compound an alkoxy- or aryloxy silane compound, to give a solid support; Step C) optionally contacting the solid support obtained with at least one activating compound; and Step D) reacting the (activated) support with a halogen-containing Ti-compound as catalytic species, an activator and at least one internal electron donor in several sub steps wherein the internal donor is added in portions during at least two of said stages to obtain a procatalyst. The invention moreover relates to a procatalyst, a catalytic system comprising said procatalyst and to a process to prepare polyolefins using said catalyst system and the polyolefins obtained therewith.

Abstract: This disclosure relates to a method and an apparatus for the delivery of a multi-component olefin polymerization catalyst to a polymerization reactor. The components soluble in a first solvent are delivered under pressure along with that solvent in a first delivery conduit. The components that are insoluble in the first solvent but are soluble in a second solvent are delivered under pressure in a second delivery conduit which is arranged coaxially with and disposed within the first conduit, such that the inner conduit and outer conduit terminate at a common catalyst component mixing conduit which extends into the polymerization reactor and in which the catalyst components mix to form an active polymerization catalyst.

Abstract: Provided is a fluorinated polymer that can impart excellent washing durability and water- and oil-repellency to fibers, said fluorinated polymer having a repeating unit derived from a fluorinated monomer (a) that comprises a first fluorinated monomer (a1) represented by the formula: CH2?C(—X1)—C(?O)—Y1—Z1—Rf1 [wherein X1 represents a halogen atom; Y1 represents —O— or —NH—; Z1 represents a direct bond or a bivalent organic group; and Rf1 represents a fluoroalkyl group having 1 to 20 carbon atoms] and a second fluorinated monomer (a2) represented by the formula: CH2?C(—X2)—C(?O)—Y2—Z2—Rf2 [wherein X2 represents a monovalent organic group or a hydrogen atom; Y2 represents —O— or —NH—; Z2 represents a direct bond or a bivalent organic group; and Rf2 represents a fluoroalkyl group having 1 to 20 carbon atoms].

Abstract: Described herein is a peroxide curable, partially fluorinated polymer derived from: (a) comonomers comprising: (i) 5-28 wt. % of tetrafluoroethylene; (ii) 30-70 wt. % of vinylidene fluoride; and (iii) a monomer selected from 10-45 wt. % of hexafluoropropylene and 10-40 wt, % of a perfluoro ether monomer of the formula Rf-0-(CF2)n—CF?CF2 wherein n is 1 or 0, and Rf represents a perfluoroalkyl residue which may or may not be interrupted by one or more than one oxygen atoms; (b) 0.01-2 wt % of a perfluorinated iodinated vinyl ether based on the total amount of comonomer, wherein the perfluorinated iodinated vinyl ether has the formula: F2C?CF—(CF2)m(0)o—(CF2)n—O—(CF2)p—I where m is 0 or 1; n is an integer of 0-5: o is 0 or 1: and p is an integer of 1-5, wherein when n is 0, o is 0; and (c) 0.01-2 wt % of a chain transfer agent based on the total amount of comonomers wherein the chain transfer agent consists of a diiodo-fluoroalkane and a diiodo-methane.

Abstract: Various embodiments disclosed relate to photopolymerizable compositions that are suitable for making three-dimensional structures when exposed to laser light.

Abstract: Process for preparing polymers comprising S-vinylthioalkanol as monomer by radical polymerization, the polymerization being carried out in aqueous solution, with the proviso that no N-vinylpyrrolidone as monomer is used for preparing the polymers, and also polymers prepared by such processes. Copolymer consisting of S-vinyl-2-thioethan-1-ol and one or more ethylenically unsaturated monomers selected from the group consisting of acrylic acid, itaconic acid, maleic acid, maleic anhydride, and vinylphosphonic acid. Mixtures, preferably aqueous compositions, comprising polymers or copolymers. Use of polymers, copolymers, or aqueous compositions as concrete plasticizers, wetting agents, in cosmetics, as adhesive constituent, in emulsion polymerization, for metal surface treatment, in coatings applications, in paints, in laundry detergents, in washing detergents, as encapsulating material or as enveloping material.

Abstract: The present invention addresses the problem of providing a method for producing an oxymethylene copolymer, which is capable of producing an oxymethylene copolymer having a high molecular weight with high yield and high economic efficiency. This problem is able to be solved by a method for producing an oxymethylene copolymer, in which a copolymer starting material containing a trioxane and a comonomer is subjected to a polymerization reaction in the presence of a polymerization initiator that contains an acidic compound (A), and wherein: the copolymer starting material contains a basic compound (B); an acidic compound (C) that is different from the acidic compound (A) is added into the copolymer starting material before performing the polymerization reaction, thereby causing a reaction between the basic compound (B) and the acidic compound (C) in advance; and the polymerization reaction is carried out by means of melt polymerization.

Abstract: A crosslinkable composition containing: a liquid monocyclic olefin ring-opened polymer (A) having a reactive group at a polymer chain end thereof and a weight-average molecular weight (Mw) of 1,000 to 50,000; and a crosslinkable compound (B) having, in the molecule, two or more functional groups reactive with the reactive group at the polymer chain end of the monocyclic olefin ring-opened polymer (A).

Abstract: A method for producing a polyurethane resin includes a reaction step of obtaining a primary product by reacting a polyisocyanate component containing a bis(isocyanatomethyl)cyclohexane with a polyol component containing a low molecular weight polyol having a number average molecular weight of 400 or less and a high molecular weight polyol having an average molecular weight of 2500 or more and 4000 or less under the presence of a bismuth catalyst, and a heat treatment step of heat treating the primary product to obtain a polyurethane resin. The bismuth catalyst content in the polyurethane resin is 0.1 ppm or more and 1000 ppm or less, and the heat treatment conditions in the heat treatment step are 50° C. or more and 100° C. or less and three days or more and ten days or less.

Abstract: The present invention is to provide a monomer mixture that is cured rapidly even in the presence of oxygen and that forms a cured product having high hardness and excellent adhesion to metals and/or glass. The monomer mixture according to an embodiment of the present invention contains two or more types of cationically polymerizable monomers. As the cationically polymerizable monomers, the monomer mixture contains at least 10 wt. %, based on a total amount of the monomer mixture, of a compound having at least one cationically polymerizable group selected from the group consisting of a vinyl ether group, an epoxy group, and an oxetanyl group, and at least one hydroxy group in a molecule, and at least 5 wt. %, based on the total amount of the monomer mixture, of a compound represented by Formula (b).

Abstract: A sheet-molding compound comprising a thickened thermosetting resin composition and reinforcing fiber bundles. The thermosetting resin composition comprises components (A), (B) and (D). The content of component (D) is 10 parts by mass to 30 parts by mass with respect to 100 parts by mass of the total amount of epoxy resin. The final viscosity of the thickened thermosetting resin composition is 150 Pa·s to 20000 Pa·s, and the minimum viscosity is 2 Pa·s to 600 Pa·s, the final viscosity being higher than the minimum viscosity.

Abstract: Provided is a sheet-like prepreg that has both a low coefficient of linear thermal expansion and high flexibility and offers excellent anti-warpage performance and cracking resistance. The sheet-like prepreg according to the present invention includes a curable composition and a sheet-like porous support impregnated with the curable composition. The sheet-like porous support is made from a material having a coefficient of linear thermal expansion of 10 ppm/K or less. The sheet-like prepreg gives a cured product having a glass transition temperature of ?60° C. to 100° C. The curable composition includes one or more curable compounds (A) and at least one of a curing agent (B) and a curing catalyst (C). The curable compounds (A) include an epoxide having a weight per epoxy equivalent of 140 to 3000 g/eq in an amount of 50 weight percent or more of the totality of the curable compounds (A).

Abstract: Embodiments of the invention relate to a novel class of polymers with superior mechanical properties and chemical stability, as compared to known polymers. These polymers are particularly well suited for use in anion exchange membranes (AEMs), including those employed in fuel cells. Novel methods for the manufacture of these polymers are also described.

Abstract: A piezoelectric actuator is provided, including a vibration plate, a piezoelectric layer, a plurality of individual electrodes arranged in two arrays, first and second common electrodes which have first and second facing portions facing parts of the individual electrodes and first and second connecting portions connecting the first and second facing portions respectively, and first and second wiring portions which are arranged on the vibration plate and which are connected to the first and second common electrodes respectively via first and second connecting wirings, wherein one of the first connecting wirings connects the first connecting portion and one of the first wiring portion while striding over the second connecting portion.

Abstract: A process for producing a polyester polyol includes the steps of: (a) preparing a diol composition which includes a C2-C9 short-chain diol component and a diol monomeric component of Formula (I) defined herein in a weight ratio of the C2-C9 short-chain diol component to the diol monomeric component of Formula (I) of larger than 0 and less than 1.6, (b) preparing a dicarbonyl composition which includes one selected from the group consisting of a dicarboxylic acid component, a dicarboxylic anhydride component, and a combination thereof, and (c) subjecting the diol composition and the dicarbonyl composition to a polycondensation reaction.

Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: The disclosure relates to moisture curable compositions based on a combination of silane-modified polymer and silane functional additive, their manufacture and use. The silane functional additive is preferably prepared from a water miscible polyol having a functionality of about 2 to about 4 and/or a polyol having a tertiary nitrogen atom in the backbone and a functionality equal or greater than about 2.

Abstract: The present disclosure provides a production method of a semi-aromatic polyamide, and a semi-aromatic polyamide. Said production method of a semi-aromatic polyamide includes: step 1 of subjecting an initial charge of a diamine and a binary acid in an amine/acid molar ratio of less than 1.0 to form a slurry together with water and a catalyst, and subjecting the slurry to heating and dissolution to form a saline solution; step 2 of dehydrating said saline solution after detecting the composition thereof, detecting the content of diamine in a steam condensate from a dehydration unit, adjusting the amine/acid molar ratio to be larger than 1.0 by a molten diamine and a monoacid as a molecular weight regulator, and performing pre-polymerization; and step 3 of subjecting a pre-polymerization solution to post-polycondensation after vacuum flashing. The semi-aromatic polyamide of the present disclosure has a low gel content, excellent performance and extensive scope of application.

Abstract: The present invention provides a process for preparing polyimides. The process includes cyclizing a polyimide precursor composition in a vacuum-like environment by using infrared radiation to give polyimide. The process can effectively reduce the cyclization temperature and time, thereby reducing energy and process costs.

Abstract: A polyimide resin including a structural unit A derived from a tetracarboxylic dianhydride and a structural unit B derived from a diamine compound, wherein the structural unit A includes a structural unit (A-1) derived from a compound represented by the following formula (a-1), and the structural unit B includes a structural unit (B-1) derived from a compound represented by the following formula (b-1): wherein m and n in the formula (b-1) each independently are an integer of 0 or 1.

Abstract: A poly(amide-imide) is provided. The poly(amide-imide) is represented by formula (1), wherein R is a C6 aryl group, a C7-C8 aralkyl group, a C2-C6 alkoxyalkyl group, or a C3-C18 alkyl group; and 0.02?X?0.5.

Abstract: A method for producing polyarylene sulfide of the present invention includes the steps of: supplying reaction raw materials to at least one of a plurality of reaction vessels mutually communicated through a gas phase; carrying out a polymerization reaction; and removing at least some of the water present in the reaction vessels. Each of the steps is carried out in parallel, and a reaction mixture is transferred sequentially between the reaction vessels. At that time, the amount of heat that is removed in the polymerization reaction is less than the amount of reaction heat of the polymerization reaction.