Patents Issued in February 25, 2020
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Patent number: 10571421Abstract: A sensor of volatile substances includes: a first electrode structure and a second electrode structure capacitively coupled, comb-fingered, and arranged coplanar in a plane; and a sensitive layer, of a sensitive material that is permeable to a volatile substance and has electrical permittivity depending upon a concentration of the volatile substance absorbed by the sensitive material. The sensitive layer extends from opposite sides of the plane.Type: GrantFiled: October 27, 2017Date of Patent: February 25, 2020Assignee: STMICROELECTRONICS S.R.L.Inventors: Antonello Santangelo, Salvatore Cascino, Roberto Modica, Viviana Cerantonio, Maurizio Moschetti, Alessandro Auditore
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Patent number: 10571422Abstract: To detect changes in the physical properties of an examination object as changes in a plurality of different oscillation frequencies using signals with the oscillation frequencies, a sensor circuit includes: an oscillation circuit (1) with a first resonant frequency; an oscillation circuit (2) with a second resonant frequency different from the first resonant frequency; and a detection circuit (4) that detects oscillation frequencies of the oscillation circuit (1) and the oscillation circuit (2).Type: GrantFiled: September 21, 2016Date of Patent: February 25, 2020Assignee: SHARP KABUSHIKI KAISHAInventors: Takeshi Mitsunaka, Kunihiko Iizuka, Akira Saito, Nobuyuki Ashida
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Patent number: 10571423Abstract: This disclosure describes a stud sensor configured to locate a stud. The stud sensor includes a housing and a sensor carried by the housing. The sensor includes two or more electrodes. The two or more electrodes are configured to form a substantially circular configuration. The stud sensor further comprises one or more processors carried by the housing. The one or more processors are communicatively coupled with the sensor. The one or more processors are configured by machine-readable instructions to calculate a stud location by measuring a change in capacitance from a fixed capacitance of a wall structure as the stud sensor is moved along a surface of the wall structure; and generate one or more signals to report a result relating to a location of a stud.Type: GrantFiled: June 23, 2017Date of Patent: February 25, 2020Assignee: STANLEY BLACK & DECKER INC.Inventors: Bruce Eidinger, Yong Cushing, Michael Murray, Bianca Linay
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Patent number: 10571424Abstract: The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition.Type: GrantFiled: August 30, 2016Date of Patent: February 25, 2020Assignee: PHC HOLDINGS CORPORATIONInventors: Motonori Uchiyama, Takuo Kouno
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Patent number: 10571425Abstract: A disposable electrochemical test sensor designed to facilitate sampling of fluid samples. It has a fluid chamber having a novel extra wide sampling entrance, but no additional air escape vent. The chamber provides a reservoir from which a sample fluid can be drawn into the chamber through capillary action. The sampling entrance provided can draw fluid into the chamber through any part of the opening, allowing easy targeting the samples with small volume, picking up smeared samples, and added tolerance to users who jam the tip of the sensor into users' finger. The sampling entrance also serves as air escape vent. Such one opening sensor alleviates over-flow issue often encountered in convenient sensors.Type: GrantFiled: February 12, 2019Date of Patent: February 25, 2020Assignee: Changsha Sinocare Inc.Inventors: Hongli Che, Shaobo Li
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Patent number: 10571426Abstract: A pixel circuit acts as a sensing element in a sensing device. The pixel circuit includes a sensing electrode, a first gate electrically connected to the sensing electrode, a second gate in electrical communication with the first gate, and a readout device that is electrically connected to the second gate. An input voltage applied to the sensing electrode is amplified between the first gate and the second gate, the amplification being measured as an output signal from the readout device to perform a sensing operation. For example, the output signal may be relatable to pH, analyte measurements, or other properties of sample liquids analyzed by the sensing device. A sensing device may include multiple pixels disposed on a substrate, each pixel including said pixel circuit. Driver circuits controlled by control electronics are configured to generate signals that selectively address the pixels and to read out voltages at the sensing electrodes.Type: GrantFiled: August 13, 2018Date of Patent: February 25, 2020Assignee: Sharp Life Science (EU) LimitedInventors: Benjamin James Hadwen, Campbell Donald Brown, Christopher James Brown, Gregory Gay, Sally Anderson
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Patent number: 10571427Abstract: A molecular detection apparatus according to an embodiment includes: a collection unit collecting detection target gas containing molecules to be detected; a detector including a plurality of detection cells each having an organic probe disposed at a sensor unit, the organic probe capturing the molecules collected in the collection unit; and a discriminator discriminating the molecules by a signal pattern based on an intensity difference of detection signals generated by the molecules being captured by the organic probes in a plurality of the detection cells. In the molecular detection apparatus according to the embodiment, at least one of the detection cells has a plurality of different types of the organic probes disposed at the sensor unit.Type: GrantFiled: February 14, 2017Date of Patent: February 25, 2020Assignee: KABUSHIKI KAISHA TOSHIBAInventors: Hirohisa Miyamoto, Ko Yamada, Reiko Yoshimura
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Patent number: 10571428Abstract: Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells, nuclei, whole chromosomes, or other sources of long DNA molecules. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules of DNA are transported to the reaction nanochannel and then fragmented in the reaction nanochannel using restriction endonuclease enzymes. The reaction nanochannel is sized and configured so that the fragments stay in an original order until they are injected into the detection nanochannel. Signal at one or more locations along the detection nanochannel is detected to map fragments in the order they occur along a long DNA molecule.Type: GrantFiled: April 10, 2018Date of Patent: February 25, 2020Assignee: The University of North Carolina at Chapel HillInventors: John Michael Ramsey, Laurent Menard
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Patent number: 10571429Abstract: A wire rope flaw detection device includes: a base unit including a magnetizer for forming a main magnetic path in the axial direction of a wire rope, and a magnetic sensor for detecting a leakage magnetic flux generated by a wire rope damaged part; and a guide unit including guide members and a guide plate which are formed in U shapes along the outer circumference of the wire rope, wherein the guide unit is fixed to the base unit.Type: GrantFiled: April 27, 2015Date of Patent: February 25, 2020Assignee: MITSUBISHI ELECTRIC CORPORATIONInventors: Yoshiyuki Terai, Takashi Yoshioka, Tomokazu Hoshinoo, Masao Akashi
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Patent number: 10571430Abstract: A chemical vapor deposition or atomic layer deposition system includes a gas concentration sensor for determining the quantity of precursor gases admitted thereto. The gas concentration sensor can include a transmitter and a receiver for transmitting an acoustic signal across a chamber. In embodiments, the transmitter and receiver are designed to increase transmitted signal while reducing transmitted noise, facilitating use of the gas concentration sensor at low pressure and high temperature.Type: GrantFiled: March 10, 2017Date of Patent: February 25, 2020Assignee: Veeco Instruments Inc.Inventors: Chi-Jung Cheng, Leo Chin, Christopher J. Morath, Arindam Sinharoy, Raymond C. Logue
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Patent number: 10571431Abstract: A fluid sensor including a sensing area configured to receive a fluid. The fluid sensor includes a transducer and a capacitive sensor. The transducer is configured to output an ultrasonic wave through the fluid. The capacitive sensor includes a capacitive plate configured to reflect the ultrasonic wave toward the transducer.Type: GrantFiled: June 2, 2017Date of Patent: February 25, 2020Assignee: SSI TECHNOLOGIES, LLCInventor: Lawrence B. Reimer
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Patent number: 10571432Abstract: Methods, systems, and devices for solid axle testing are provided.Type: GrantFiled: August 30, 2017Date of Patent: February 25, 2020Assignee: General Electric CompanyInventors: Luca Scaccabarozzi, Tobias Bruch
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Patent number: 10571433Abstract: An adjustable fixture for holding a sample for inspection with a scanning acoustic microscope includes a first horizontal bar disposed on a first end of a frame, and a second horizontal bar disposed on a second end of the frame. The second horizontal bar may be engaged with the frame to be movable between the first end and the second end of the frame. The adjustable fixture may further include a side bar disposed on one or more of the first side and the second side of the frame, with an end of the second horizontal bar slidable and lockable along the side bar, and an engagement mechanism releasably coupling the end of the second horizontal bar to the side bar.Type: GrantFiled: July 17, 2017Date of Patent: February 25, 2020Assignee: Sonix, Inc.Inventors: Paul Ivan John Keeton, James Christopher Patrick McKeon, Michael Lemley Wright, Kevin John Brault
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Patent number: 10571434Abstract: The invention provides embodiments of an apparatus and for improved, higher quality and higher resolution acoustic impedance scanning of an object through a barrier. Such acoustic impedance scanning can be employed to obtain biometric information of a person via fingerprint pattern.Type: GrantFiled: July 1, 2019Date of Patent: February 25, 2020Assignee: SONAVATION, INC.Inventor: Rainer M. Schmitt
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Patent number: 10571435Abstract: An ultrasonic transducer and generator assembly and method for controlling the assembly are disclosed. The method includes sensing a current signal and a voltage signal at the transducer, differentiating the voltage signal, multiplying the differentiated voltage signal by a bulk capacitance value to determine a bulk capacitance current signal, determining the difference between the current signal and the bulk capacitance current signal to determine a motional current signal corresponding to mechanical motion of the transducer, determining an updated bulk capacitance value based on the determined motional current signal and the bulk capacitance current signal, generating a transducer signal based on the motional current signal, and driving the transducer with the transducer signal. The method may further include filtering the difference between the current signal and the bulk capacitance current signal using a band-pass filter.Type: GrantFiled: June 8, 2017Date of Patent: February 25, 2020Assignee: Covidien LPInventor: James A. Gilbert
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Patent number: 10571436Abstract: An apparatus includes a transducer array with a plurality of CMUT elements. Each of the plurality of CMUT elements includes a first end and a second end. The transducer array further includes a bias network that is electrically connected with the first and second ends of the plurality of CMUT elements. The bias network applies a first bias voltage to the first end of the plurality of CMUT elements and a second bias voltage to the second end of the plurality of CMUT elements. The first and second bias voltages bias the plurality of CMUT elements. A method includes biasing, with bias network, a CMUT element of an transducer array using a bipolar signal that includes a first bias voltage and a second bias voltage, transmitting, by a transmit circuit, a transmit signal to the CMUT element, receiving, by a receive circuit, a receive signal from the CMUT element.Type: GrantFiled: August 25, 2014Date of Patent: February 25, 2020Assignee: B-K Medical ApsInventors: Jan P. Bagge, Lars N Moesner, Henrik Jensen
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Patent number: 10571437Abstract: Operational configuration and temperature compensation methods are provided for bulk acoustic wave (BAW) resonator devices suitable for operating with liquids. Temperature compensation methods dispense with a need for temperature sensing, instead utilizing a relationship between (i) change in frequency of a BAW resonator at a phase with adequate sensitivity and (ii) change in frequency of a phase that is correlated to temperature. Operational configuration methods include determination of an initial phase response of a BAW resonator in which temperature coefficient of frequency is zero, followed by comparison of sensitivity to a level of detection threshold for a phenomenon of interest.Type: GrantFiled: December 15, 2016Date of Patent: February 25, 2020Assignee: QORVO US, INC.Inventors: Rick Morton, Kevin McCarron
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Patent number: 10571438Abstract: At least one baseline structural interrogation of a physical structure is performed in one or more corresponding baseline conditions of the structure. The one or more baseline conditions are stored, and one or more current conditions are sensed. It is determined whether a difference between the one or more current conditions and the one or more baseline conditions satisfies at least one threshold deviation criterion. A current structural interrogation of the structure is performed in response to determining that the difference between the one or more current conditions and the one or more baseline conditions satisfies the least one threshold deviation criterion. An indication that the at least one threshold deviation criterion is not satisfied is output in response to determining that that the difference between the one or more current conditions and the one or more baseline conditions does not satisfy the at least one threshold deviation criterion.Type: GrantFiled: June 9, 2017Date of Patent: February 25, 2020Assignee: Simmonds Precision Products, Inc.Inventors: Arthur Berenbaum, Travis Gang, Peter J. Carini
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Patent number: 10571439Abstract: An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.Type: GrantFiled: July 16, 2018Date of Patent: February 25, 2020Assignee: DIONEX CORPORATIONInventors: Kannan Srinivasan, Glenn M. Kuse, Rong Lin, Sheetal Bhardwaj
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Patent number: 10571440Abstract: A two-dimensional liquid chromatographic analyzer, in which a temperature control part changes a temperature in a single-step manner and switches the temperature at a high speed. Also, the temperature control part has a holder around a separation column so that the temperature of the separation column can be changed to a preset temperature. A first separation column thereof changes elution time(s) of the objective component(s) by temperature modulation and the mobile phase of the first separation column is an aqueous mobile phase having a constant composition.Type: GrantFiled: February 5, 2019Date of Patent: February 25, 2020Assignee: HITACHI HIGH-TECH SCIENCE CORPORATIONInventors: Katsutoshi Shimizu, Hideko Kanazawa
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Patent number: 10571441Abstract: The invention discloses a piston for a process column, said piston comprising a top side and a bed contact side, wherein said top side comprises a drainage trench.Type: GrantFiled: December 8, 2014Date of Patent: February 25, 2020Assignee: GE Healthcare Bio-Sciences ABInventors: Andreas Bergstrom, Stefan Kjell Eriksson
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Patent number: 10571442Abstract: A technique and device to determine the spectrum of electromagnetic radiation in a certain range of wavelengths comprising: splitting said radiation into more than one beam; let these beams counter-propagate in a Sagnac-type ring interferometer; and imprinting a wavelength-dependent angular tilt onto the wavefront of each beam by at least one dispersive element which preferably is a transmission grating or grism; and re-combining the multiple beams on a detector that exhibits spatial resolution and can therefore resolve the fringes formed by interference; and perform the mathematical operations to determine the spectrum of said radiation from the obtained interferogram, wherein the dispersive element is mounted on a stage providing linear and/or rotational movement.Type: GrantFiled: November 2, 2016Date of Patent: February 25, 2020Inventor: Matthias Lenzner
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Patent number: 10571443Abstract: A gas concentration detecting device and a detecting method thereof are provided. The gas concentration detecting device includes: a first polarizer; a second polarizer arranged opposite to the first polarizer in such a way that a gap is formed between the first polarizer and the second polarizer; a light source on a side of the second polarizer away from the first polarizer or on a side of the first polarizer away from the second polarizer; and a photoluminescent layer between the first polarizer and the second polarizer. The light transmission axis of the first polarizer is perpendicular to a light transmission axis of the second polarizer.Type: GrantFiled: September 21, 2018Date of Patent: February 25, 2020Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventor: Yingyi Li
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Patent number: 10571444Abstract: A computer program product for providing data to a distributed blockchain database includes a computer readable storage medium having program instructions embodied therewith. The program instructions are executable by a computer to cause the computer to receive sensor data from a first sensor unit at a first location, receive additional data corresponding to a first parameter at the first location and forecast data corresponding to the first parameter at the first location, convert the sensor data into a standardized format, generate predicted future sensor data based on a comparison between the additional data, the sensor data, and the forecast data, write the sensor data, the additional data, and predicted future sensor data into a ledger. and submit the ledger to a distributed blockchain database.Type: GrantFiled: April 27, 2017Date of Patent: February 25, 2020Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Risham Y. Chokshi, Autumn Good, William Livesey, Andie Schroeder
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Patent number: 10571445Abstract: A method for detecting chemical vapors includes acquiring an environmental air sample within at least one fielded chemical detector, detecting that at least one chemical from a selected set of possible chemicals is present within the environmental air sample, analyzing data relating to the detecting, determining at least one of a chemical name, a chemical concentration, a chemical category, or a toxicity level, and transmitting the determined information to a central data collection site.Type: GrantFiled: May 15, 2017Date of Patent: February 25, 2020Assignee: Hamilton Sundstrand CorporationInventors: Richard K. Trubey, Hsien-Chi W. Niu
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Patent number: 10571446Abstract: A system, a computer readable storage medium, and a method for data quality control using a correlated sensor group includes selecting a sensor group, by at least one processor, according to a uniformity and a correlation with air pollution concentration data from a reference station, selecting a time series based on the correlation, generating a particle concentration model between the sensor group and the reference station, calculating a deviation in the particle concentration data from the particle concentration model, and recognizing outliers from the deviation as unacceptable data.Type: GrantFiled: April 27, 2017Date of Patent: February 25, 2020Assignee: International Business Machines CorporationInventors: Wen Chen Cheng, Xin Jie Lv, Xiao Guang Rui, Ling Yun Wang, Wen Jun Yin, Yu Ed Zhao
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Patent number: 10571447Abstract: A monitoring system is configured to detect a threshold amount of petroleum in a storm water-based fluid of an oil handling facility. For instance, the storm water-based fluid can be drained from a floating roof of a petroleum storage tank, a diked area, or a retention pond.Type: GrantFiled: April 22, 2016Date of Patent: February 25, 2020Inventors: Mark S. Rauch, Ronald Kleineke
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Patent number: 10571448Abstract: Disclosed are a method and a system for comprehensive evaluation of organic compound and heavy metal pollution in water based on fish electro-cardio, and fish electro-cardio signals are acquired by a real-time and miniaturized fish electro-cardio acquisition system which includes a real-time and miniaturized fish electro-cardio acquisition device, then a change of the electro-cardio index in a QT interval is obtained for assessing the corresponding organic compound in water to be tested, and a change of the electro-cardio index in a QRS interval is obtained for assessing the corresponding heavy metal in water to be tested. Based on fish electro-cardio acquired continuously on-line in real-time while keeping fish swims in a normal state and the water quality parameters acquired by various water quality sensors, water quality is online analyzed and water sudden pollution is online monitored and assessed.Type: GrantFiled: August 29, 2019Date of Patent: February 25, 2020Assignees: SHANDONG NORMAL UNIVERSITY, JINAN BIOSENSOR INSTRUMENT CO., LTD, SOUTH CHINA INSTITUTE OF ENVIRONMENTAL SCIENCES. MEPInventors: Zongming Ren, Baichuan Ren, Linlin Qiao, Baixiang Ren, Yuedan Liu
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Patent number: 10571449Abstract: The invention relates to a method suitable for detecting, capturing and/or selectively releasing chemical elements selected from poor metals, alkalines, alkaline earths, actinides and rare earths. Said method involves a molecular assembly formed by at least one amine, and at least one aldehyde and/or an imine and/or CO2, or an adduct formed by the contact between an amine and CO2, and at least one of said chemical elements. The invention also relates to a kit for implementing said method for detection, capture and/or release.Type: GrantFiled: May 20, 2014Date of Patent: February 25, 2020Assignees: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE CENTRALE DE MARSEILLE, UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL)Inventors: Julien Leclaire, Gabriel Canard, Frédéric Fotiadu, Guillaume Poisson
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Patent number: 10571450Abstract: Methods of incendivity testing include applying a flexible sheet over a test article to form a sealed space between the flexible sheet and a surface region of the test article. Methods further include filling the sealed space with an indicator gas mixture, applying an energy discharge to the test article, and determining whether the indicator gas mixture in the sealed space reacted in response to the energy discharge. The indicator gas mixture may be flammable and may be formed while filling the sealed space. Incendivity test systems include the test article, the flexible sheet sealed to the test article to form the sealed space, a gas control module configured to fill, flush, purge, and/or sample gas in the sealed space, and an energy source configured to apply the energy discharge to the test article.Type: GrantFiled: September 13, 2016Date of Patent: February 25, 2020Assignee: The Boeing CompanyInventors: Philipp Andreas Boettcher, Eddie Kwon, Jason Scott Damazo
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Patent number: 10571451Abstract: A method of monitoring the drilling of a wellbore having a drilling fluid that circulates in the wellbore during drilling, comprises: Extracting a plurality of gaseous compounds from a sample of drilling fluid exiting the wellbore, Measuring a quantity y(i) of at least a group of compounds, each group comprises comprising at least one extracted gaseous compound, Determining, from the measured quantity y(i) and an extraction coefficient ?(i) associated to each group, the content x(i) of each group of gaseous compounds present in the sample of drilling fluid, Deriving a drilling indicator from the content x(i) of at least one group of gaseous compounds.Type: GrantFiled: February 3, 2017Date of Patent: February 25, 2020Assignee: GEOSERVICES EQUIPEMENTSInventors: Ivan Fornasier, Ilaria De Santo, David Cook, Jacques Chedotal, Slim Hbaieb
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Patent number: 10571452Abstract: A system and a method are provided for calculating one or more indicative properties, e.g., one or more of the cetane number, octane number, pour point, cloud point and aniline point of oil fractions, from the density and high pressure liquid chromatography (HPLC) data of a sample of the crude oil.Type: GrantFiled: June 30, 2017Date of Patent: February 25, 2020Assignee: Saudi Arabian Oil CompanyInventors: Omer Refa Koseoglu, Adnan Al-Hajji, Saroj Kumar Panda
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Patent number: 10571453Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.Type: GrantFiled: December 26, 2018Date of Patent: February 25, 2020Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Fred Paul Mark Jjunju, Anyin Li, Iman S. Roqan
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Patent number: 10571454Abstract: A method of board lumber grading is performed in an industrial environment on a machine learning framework configured as an interface to a machine learning-based deep convolutional network that is trained end-to-end, pixels-to-pixels on semantic segmentation. The method uses deep learning techniques that are applied to semantic segmentation to delineate board lumber characteristics, including their sizes and boundaries.Type: GrantFiled: March 5, 2018Date of Patent: February 25, 2020Assignee: Lucidyne Technologies, Inc.Inventors: Revathy Narasimhan, Patrick Freeman, Hayden Michael Aronson, Kevin Johnsrude, Chris Mosbrucker, Dan Robin, Ryan T. Shear, Joseph H. Weintraub, Eric N. Mortensen
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Patent number: 10571455Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.Type: GrantFiled: February 28, 2019Date of Patent: February 25, 2020Assignee: Quest Diagnostics Investments IncorporatedInventors: Changming Yang, Sum Chan
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Patent number: 10571456Abstract: Provided is an electrical measuring cartridge including at least: a biological sample holding section that accommodates a liquid biological sample containing a sedimenting component; a measuring electrode unit that is fixed to the biological sample holding section and composed of a pair of electrodes for electrically measuring a state of the biological sample; and a sedimentation measuring electrode unit that is fixed to a position at a different height from the measuring electrode unit of the biological sample holding section and composed of a pair of electrodes for electrically measuring a degree of sedimentation of the sedimenting component.Type: GrantFiled: June 2, 2015Date of Patent: February 25, 2020Assignee: SONY CORPORATIONInventors: Yoichi Katsumoto, Marcaurele Brun, Yoshihito Hayashi
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Patent number: 10571457Abstract: The problem of confirming the presence of an adulterant in a urine sample is solved by the use of a reagent capable of reacting with uric acid and non-urate markers in a urine sample. In one embodiment, a phosphotungtate reagent is used to react with the urine sample to create a blue coloration in the presence of uric acid or uric acid equivalents. A reduction or elimination of the blue coloration, resulting in a reduction in the light absorbance, of the urine sample can be used as an indicator of the historical presence of an adulterant. An Oxidant History test can also be generated using the phosphostungtate reagent, wherein the light absorbance resulting from the blue coloration is measured over time, with a measured reduction in the absorbance being an indication that an adulterant is or has been present in the urine sample and is oxidizing the uric acid and non-urate markers over time.Type: GrantFiled: September 24, 2018Date of Patent: February 25, 2020Assignee: VISION DIAGNOSTICS, INC.Inventor: Jerry W. Denney
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Patent number: 10571458Abstract: A method and a device for determining the emission of greenhouse gas, in particular methane, by ruminants, in particular dairy animals includes counting eructations (“belches”) of the animal. This is done by measuring a signal linked to the eructations, for example sound with a microphone. Given that the methane content of an eructation of this type is more or less constant, the total methane emission can be derived therefrom by counting.Type: GrantFiled: June 18, 2015Date of Patent: February 25, 2020Assignee: LELY PATENT N.V.Inventor: Patrick Philip Jacob Van Der Tol
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Patent number: 10571459Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.Type: GrantFiled: January 17, 2017Date of Patent: February 25, 2020Assignee: RUN THEM SWEET, LLCInventors: Michael A. Horning, George A. Brooks
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Patent number: 10571460Abstract: This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.Type: GrantFiled: May 19, 2017Date of Patent: February 25, 2020Assignee: Wisconsin Alumni Research FoundationInventors: Michael R. Sussman, J. Leon Shohet, Faraz A. Choudhury, Joshua M. Blatz, Benjamin B. Minkoff, Daniel I. Benjamin
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Patent number: 10571461Abstract: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.Type: GrantFiled: October 12, 2016Date of Patent: February 25, 2020Assignee: Massachusetts Institute of TechnologyInventors: David T. Eddington, Sangeeta N. Bhatia
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Patent number: 10571462Abstract: This disclosure relates to the technical field of liver transplantation and discloses a set of biomarkers that can be used to assess the quality of the liver graft before transplantation. More specifically, this disclosure describes a process of predicting the appearance of primary non function (PNF) of a liver graft via determining the relative abundance of the undergalactosylated glycans in the perfusate N-glycome of the liver before transplantation.Type: GrantFiled: June 30, 2016Date of Patent: February 25, 2020Assignee: Universiteit GentInventors: Hans Van Vlierberghe, Xavier Verhelst
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Patent number: 10571463Abstract: Materials, systems and methods are provided for qualitative assessment of exposure of a person to ionizing radiation by measuring amounts of the biomarkers, wherein a change compared with corresponding un-irradiated control reference ranges of the biomarkers, provides the assessment, wherein the biomarkers include (i) alpha-1-Antichymotrypsin (ACT), (ii) Fms-related tyrosine kinase 3 ligand (Flt3L), and (iii) one or more additional proteins.Type: GrantFiled: July 23, 2018Date of Patent: February 25, 2020Assignee: SRI INTERNATIONALInventors: David E. Cooper, Robert Balog, Polly Chang, Thomas A. Shaler, Hua Lin, Annalisa D'Andrea, Travis Harrison, Roger H. Schmidt, Christina Swanson, Estevan Mendoza, Mark Steele, Pablo E. Garcia
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Patent number: 10571464Abstract: The invention relates to methods, reagents and devices for detecting an analyte in a sample.Type: GrantFiled: October 9, 2013Date of Patent: February 25, 2020Assignee: Orgentec Diagnostika GmbHInventors: Vinzenz Kirste, Wigbert Berg, Vukic Soskic
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Patent number: 10571465Abstract: Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.Type: GrantFiled: December 10, 2015Date of Patent: February 25, 2020Assignee: The University of Maryland, BaltimoreInventors: Henryk Szmacinski, Joseph R. Lakowicz
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Patent number: 10571466Abstract: The invention relates to the use of an immunologically reactive microbial transglutaminase or its immunologically reactive parts or analogues, which are present in a complex with gliadin or its immunologically reactive parts or analogues, for the diagnosis and/or therapy control of coeliac disease or sprue as well as gluten sensitivity, and a kit for determining the diagnosis and/or therapy control of coeliac disease or sprue as well as of gluten sensitivity, by means of the previously mentioned complex.Type: GrantFiled: April 17, 2013Date of Patent: February 25, 2020Assignee: Aeneas GmbH & Co. KGInventors: Torsten Matthias, Sasha Pfeiffer, Kai Prager, Christian Meesters, Patricia Jeremias
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Patent number: 10571467Abstract: In some aspects, the present invention provides methods for predicting whether a subject will develop autoantibodies to an anti-TNF? drug during the course of anti-TNF? drug therapy. In other aspects, the present invention provides methods for predicting the level of an anti-TNF? drug in a subject during the course of anti-TNF? drug therapy. Systems for predicting anti-TNF? drug levels and the likelihood of autoantibody formation during the course of anti-TNF? drug therapy are also provided herein. The present invention further provides methods for predicting a clinical outcome (e.g., endoscopic response) of a subject on anti-TNF? drug therapy.Type: GrantFiled: April 12, 2017Date of Patent: February 25, 2020Assignee: Prometheus Biosiences, Inc.Inventors: Sharat Singh, Venkateswarlu Kondragunta
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Patent number: 10571468Abstract: The invention is directed to engineered Fc gamma receptor type III (Fc?111, HNA-1) polypeptides and use of these polypeptides to detect antibodies specific for human neutrophil antigens (HNA). The invention is also directed to methods for the diagnosing and determining susceptibility for developing Transfusion Reaction Acute Lung (TRALI).Type: GrantFiled: May 7, 2015Date of Patent: February 25, 2020Assignee: ONE LAMBDA, INC.Inventors: Jar-How Lee, Neng Jen Remi Shih, Julie Nguyen, Rui Pei
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Patent number: 10571469Abstract: A kit for labeling bacteria, the kit including: an analog of an endogenous monosaccharide residue of glycans of the outer membrane of a given category of bacteria, the endogenous monosaccharide residue being an ulosonic acid or ulosonate salt residue, the analog of a monosaccharide compound being a modified monosaccharide substituted at a given position by a first reactive group capable of reacting with a second reactive group of a labeling molecule; the labeling molecule having the second reactive group capable of reacting with said first reactive group; reactants for generating the reaction of the first reactive group of the analog residue incorporated within the glycans of the outer membrane of the bacteria with the second reactive group of the labeling molecule; and a culture or incubation medium allowing growth of the given category of bacteria, specific to the growth of the given category of bacteria.Type: GrantFiled: October 14, 2016Date of Patent: February 25, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SUDInventors: Sam Dukan, Audrey Dumont, Monzer Awwad, Annie Malleron, Boris Vauzeilles
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Patent number: 10571470Abstract: The biological information measurement system of the present invention includes a test subject-side device provided in a toilet installation room, and a server communicable with the test subject-side device, the test subject-side device includes a sulfur-containing gas sensor sensitive to sulfur-containing gas and outputting detection data, a transmitter-receiver transmitting measurement data including detection data of the sulfur-containing gas detected by the sulfur-containing gas sensor to the server, and the server includes a database in which measurement data including detection data of sulfur-containing gas detected by the sulfur-containing gas sensor is accumulated and recorded with dates and times of defecation acts by being associated with test subject identification information, and server-side data analyzer that analyzes physical condition of a test subject on the basis of a time-dependent variation tendency of the measurement data accumulated and recorded in the database.Type: GrantFiled: December 14, 2015Date of Patent: February 25, 2020Assignee: TOTO LTD.Inventors: Aya Hasegawa, Tetsuhiro Wasada, Aya Takao, Satoko Kizuka, Hidenori Oka, Akemi Takeshita, Masayuki Nagaishi, Koji Sonoda, Shingo Yamaya, Hiroshi Tsuboi