Patents Issued in March 17, 2020
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Patent number: 10588812Abstract: Disclosed is a dual-receptacle carrier that is generally configured for attachment to a rollator or walker and that is configured to retain either a beverage or a mobile device, such as a cellular telephone. The device comprises a body, a base, and first and second opposing retention arm portions that are configured as a receptacle for a beverage. The first and second opposing retention arm portions and base include recesses that define a receptacle for an electronic device.Type: GrantFiled: July 17, 2018Date of Patent: March 17, 2020Assignee: Medline Industries, Inc.Inventors: Todd Brockway, Emily Berman, Caren Wax, Tambra Martin, William Elliott Brooks, Robert W. Sheldon, Gregory J. Foster
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Patent number: 10588813Abstract: A system for assisting a person to rise from or recline to a sitting position is disclosed employing a walker or cane having a connector that enables attachment and detachment with an anchor attached to the floor.Type: GrantFiled: May 31, 2016Date of Patent: March 17, 2020Inventor: Bruce A. Grifhorst
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Patent number: 10588814Abstract: Walker including a frame, a movement enabling system on the frame that enables the frame to be moved along a surface, and a cueing system that generates audio and/or visual cues to enable a user of the walker to be guided in their forward movement of the walker. The cueing system includes a control unit that generates signals based on stored content relating to cue generation, at least one cue generator that generates the audio and/or visual cues based on the signals generated by the control unit, and a communications module coupled to the control unit and that receives via at least one communications frequency transmissions to set or modify the stored content. The control unit sets or modifies the stored content based on the transmissions received by the communications module.Type: GrantFiled: June 14, 2018Date of Patent: March 17, 2020Assignee: ATTI International Services Company, Inc.Inventors: Richard Engel, Eli Levi
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Patent number: 10588815Abstract: A collapsible upright wheeled walker with adjustable armrests that support sufficient user upper-body weight to facilitate a natural upright gait and provide unassisted mobility for a wide range of mobility-impaired individuals. The apparatus may be easily and quickly folded (and unfolded) and may include bilateral stabilizing wheel suspensions to facilitate navigation over uneven terrain. The apparatus includes a frame-stiffening folder assembly and may also include mechanical brakes, an adjustable upper armrest assembly with removable padded forearm supports and two pairs of handles, at least one of which is disposed sufficiently forward to place the user within the polygonal footprint defined by the front and rear wheels to provide support without leaning, stooping, or risking falls.Type: GrantFiled: April 29, 2019Date of Patent: March 17, 2020Assignee: Protostar, Inc.Inventors: Peter James Fellingham, Yichuan Pan, David A Purcell, Nebojsa Sataric
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Patent number: 10588816Abstract: A multi-feature adult massager has a plurality of cavities that traverse into and intersect within a structural body made from a soft material for massaging purposes. The cavities are internally textured in various different ways, providing a variety of massaging experiences. Furthermore, multiple entrances enable multiple users to participate simultaneously. The structural body has a geometric shape that facilitates placement and orientation of the internal cavities.Type: GrantFiled: April 14, 2017Date of Patent: March 17, 2020Inventor: Lucas Roy Adams
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Patent number: 10588817Abstract: A vacuum-driven adapter for sexual stimulation includes a primary conduit extending from a base to a crown. The crown is tapered such that when it is inserted into a hose of a running vacuum, it is partially sucked into the vacuum hose to secure the conduit to the hose via a suction fit. At the base is an opening sized to longitudinally receive a male member therethrough. Air flowing into the primary conduit on its way to the vacuum hose vibrates the male member like a reed of a wind instrument. An aperture near the crown is plugged by the user to maintain suction during use; unplugging the aperture may break the seal of the suction fit. Tuning apertures direct air to the male member and can be plugged and unplugged to manipulate air flow and stimulation. Secondary and tertiary conduits nest in the primary conduit to provide sizing options.Type: GrantFiled: February 11, 2016Date of Patent: March 17, 2020Inventor: Kevin Joseph Dorsey
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Patent number: 10588818Abstract: An articulating bed incorporating a frame employs a support member for a mattress secured to a frame for articulating motion. An upper body portion of the support member is rotatable through a range of motion from an aligned position with the frame to a fully elevated position angularly supporting the upper body portion in a raised position. A massage exciter is affixed to a bottom surface of the support member and is operative to sonically engage the flexible support.Type: GrantFiled: December 4, 2018Date of Patent: March 17, 2020Assignee: Ergomotion, Inc.Inventors: Joey Krueger, Joseph Ermalovich
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Patent number: 10588819Abstract: A method, in which a fan equipped stove of a sauna is controlled automatically between an idle mode and a sauna bathing mode of the heating of the stove based on relative air humidity of the sauna; sound measured from the sauna; a measured load on benches of the sauna; a motion sensing signal measured from the sauna and/or the temperature of the stove. A controller, a stove and a sauna using the method are also described.Type: GrantFiled: May 24, 2017Date of Patent: March 17, 2020Inventor: Risto Tapio Yli-Kovero
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Patent number: 10588820Abstract: Some people need to carry their medicines with them wherever they go. However, people can damage their medicines by leaving them outside in hot or cold weather. Specially designed systems can help increase safety by notifying people if their medicine is left behind or is getting too hot or cold.Type: GrantFiled: October 19, 2017Date of Patent: March 17, 2020Inventors: Sandy Wengreen, Eric John Wengreen
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Patent number: 10588822Abstract: An apparatus for coating pharmaceutical particles such as drug dosage forms or pellets is provided which includes a drum assembly mounted for rotation about a cylindrical axis of the drum and which includes an outer drum section and an inner perforated drum section mounted concentrically on an interior of the outer drum section such that an annular chamber is formed between the perforated inner drum section and the outer drum section. Two or more baffle plates are attached between an outer surface of the inner perforated drum and an inner surface of the outer drum which are configured to act as baffles to restrain or regulate the flow of air which define two or more compartments depending on the number of baffle plates. One end of the drum assembly includes an end plate with a central aperture for use in loading pellets into the drum and provide access to coating constituents that are pumped into the drum interior during the coating process.Type: GrantFiled: October 2, 2017Date of Patent: March 17, 2020Assignee: NINGBO WESTON POWDER PHARMA COATINGS CO., LTD.Inventors: Jingxu Zhu, Yingliang Ma, Qingliang Yang, Yunhan Zhang
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Patent number: 10588823Abstract: A system comprising one or more of a programmable encapsulation for containing and regulating the release of a medicament, an encapsulating device used by a manufacturer which encloses the medicament within a programmable encapsulation, a programming device used by a pharmacy or dispensary which programs the encapsulation with an intended patient's health data and prescription data, a consumer encapsulation storage device configured to store one or more programmable encapsulations for one or more of a patient, authenticate the identity of a patient, and dispense medicaments to the patient in accordance with the patient's prescription, and a portable reader configured to scan a programmable encapsulation and display the details of the medicament and instructions for its consumption.Type: GrantFiled: June 26, 2018Date of Patent: March 17, 2020Inventor: Rakesh Arora
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Patent number: 10588824Abstract: A pill dispensing system and associated methods are configured for managing the distribution of pills to a patient. In at least one embodiment, an at least one tamper-proof pill storage container provides an at least one pill magazine positioned within a housing of the pill storage container and configured for storing and selectively dispensing a plurality of pills through a pill outlet provided by the housing. A patient application, residing in memory on an at least one patient device under the control of the patient, is in selective communication with the at least one pill storage container. An at least one monitoring device is in selective communication with the patient application, the at least one monitoring device configured for assisting the patient application with monitoring an at least one vital of the patient.Type: GrantFiled: July 16, 2019Date of Patent: March 17, 2020Inventor: John Hsu
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Patent number: 10588825Abstract: A pill compliance device maintains a patient's pill supply and monitors the patient's access to pills contained in the device to memorialize the patient's compliance with his/her pill-taking regimen. The device has a housing, including an inner pill or capsule storage compartment and an electronics unit, a removable cover, a switch to detect removal of the cover and magnet away from the housing, and to detect a replacement of the cover and magnet to the housing, wherein activating the switch triggers a transition from an active state, to a dormant state, and vice versa. A transition from the dormant state to the active state, by replacing the cover to the housing generates a pill-taken signal. A microcontroller generates a compliance notification signal that is communicated to a Wi-Fi module or router within or attached to the electronics unit, to memorialize the apparent compliance.Type: GrantFiled: December 12, 2018Date of Patent: March 17, 2020Inventors: Manan Shukla, Mayank Shukla
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Patent number: 10588826Abstract: There is provided an apparatus for monitoring compliance, facilitating automatic dispensing and childproofing strip packaged medication. In one embodiment a dispenser advances a packet, controls advancement of the packet and detects the presence and absence of the packet, including electronic circuitry for recording events. A replicate for strip package medication can have packets with an open conductive trace, each packet being rupturable at a location to interrupt conductivity of the conductive trace. When the conductive trace of one of the packets completes an external circuit, the circuit is interrupted when the packet is ruptured. In another aspect, each packet has a tuned antenna that is tuned to an external transceiver which detects the detuning of each antenna. In a method of making a replicate for strip package medication, conductive ink is printed on a surface of each packet of the replicate and longitudinal edges of the replicate are reinforced.Type: GrantFiled: November 4, 2015Date of Patent: March 17, 2020Assignee: INTELLIGENT DEVICES SEZC INC.Inventors: Allan Wilson, Dean Brotzel, Michael Petersen
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Patent number: 10588827Abstract: Gastric and intestinal feeding tube devices and methods can be enhanced to provide better patient outcomes. For example, this document provides gastric and intestinal feeding tube devices that include an external bumper with pressure sensors and pressure indicators that facilitate usage of the feeding tube devices within an appropriate range of skin surface pressure. This document also provides external bumpers with deflectable elements that facilitate the application of a controlled amount of force between the external bumpers and the skin surface.Type: GrantFiled: March 27, 2017Date of Patent: March 17, 2020Assignee: Mayo Foundation for Medical Education and ResearchInventors: Paul A. Lorentz, Manpreet S. Mundi, Drew J. Smith, Stephen M. Corner
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Patent number: 10588828Abstract: A teething scarf includes a fabric sheet having a length, a width, and a thickness, the width being greater than the thickness. The fabric sheet forms a continuous loop along the length. The teething scarf also includes a teething element coupled with the fabric sheet. The teething element includes a non-toxic material and being configured for use in easing pain associated with teething in infants.Type: GrantFiled: January 24, 2018Date of Patent: March 17, 2020Assignee: The Boppy Company, LLCInventors: Haley Gibbons, Jessica Gladstone
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Patent number: 10588829Abstract: The invention relates to the application of photon energy to energize dental materials to enhance their physical handling characteristics, efficacy, ability to be delivered, reactivity, polymerization, and/or post-cure mechanical properties, among other attributes.Type: GrantFiled: January 11, 2019Date of Patent: March 17, 2020Assignee: Inter-Med, Inc.Inventors: John Baeten, Alex Johnson, Brett Arand
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Patent number: 10588830Abstract: The present invention relates to a dental composition comprising a specific polymerization initiator system comprising a compound having an acylsilyl- or acylgermanyl-group. The present invention also relates the use of the compound having an acylsilyl- or acylgermanyl group for the preparation of a dental composition.Type: GrantFiled: October 7, 2016Date of Patent: March 17, 2020Assignee: DENTSPLY SIRONA INC.Inventors: Joachim E. Klee, Florian Szillat, Maximilian Maier, Helmut Ritter, Jacques Lalevee, Jean Pierre Fouassier, Fabrice Morlet-Savary, Celine Dietlin, Mariem Bouzrati-Zerelli, Christoph P Fik
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Lightening process using a substrate bearing at least one oxidizing agent and an aqueous composition
Patent number: 10588831Abstract: The present invention relates to the field of lightening keratin fibres and more particularly to the field of lightening the hair. The present invention relates to a process for lightening keratin fibres, in particular human keratin fibres such as the hair, which consists in using on the said fibres i) a substrate comprising on its surface one or more chemical oxidizing agents preferably in solid form, and ii) an aqueous composition preferably comprising one or more chemical oxidizing agents. The present invention also relates to a process for preparing the said substrate thus pretreated.Type: GrantFiled: December 29, 2014Date of Patent: March 17, 2020Assignee: L'OREALInventors: Henri Samain, Philippe Rapold -
Patent number: 10588832Abstract: The present application relates to sunscreen formulations, including foamable sunscreen formulations, that comprise zinc oxide and titanium dioxide particles, suitably in the size range of about 1-100 nm. The compositions suitably produce a minimal residual whitening effect when applied to a skin surface.Type: GrantFiled: December 28, 2017Date of Patent: March 17, 2020Assignee: FALLIEN COSMECEUTICALS, LTD.Inventors: David J. Milora, Harry Fallick
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Patent number: 10588833Abstract: Teeth can be hardened and made more resistant to acid damage if treated with compositions that allow for the remineralization and demineralization of minerals found in teeth. Exchanging ions in hydroxyapatite for fluoride or other metal ions can result in teeth that are more resistant to chemical and physical insults.Type: GrantFiled: January 17, 2019Date of Patent: March 17, 2020Assignee: The Procter & Gamble CompanyInventors: Arif Ali Baig, Aaron Reed Biesbrock, Jennifer M. Kennedy, Samuel James St. John
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Patent number: 10588834Abstract: Emollient composition comprising at least one hydrocarbon oil having an isoparaffin content of 90 to 100% by weight, a normal paraffin content of 0 to 10% by weight and a content of carbon of biological origin greater than or equal to 90% with respect to the total weight of hydrocarbon oil.Type: GrantFiled: September 14, 2016Date of Patent: March 17, 2020Assignee: TOTAL MARKETING SERVICESInventor: Benjamin Swoboda
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Patent number: 10588835Abstract: This invention relates to a dual phase mouthwash comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, wherein the hydrophilic phase comprises an effective amount of a preservative selected from potassium sorbate, sodium benzoate, benzyl alcohol, and a combination thereof, and CPC and a monovalent acid, as well as to methods of using and of making such compositions.Type: GrantFiled: December 20, 2017Date of Patent: March 17, 2020Assignee: Colgate-Palmolive CompanyInventors: Jeffrey Merl Miller, Venda Porter Maloney, Donghui Wu, Adam Pepperney, Hongwei Shen, Vyoma Patel, Chi-Yuan Cheng
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Patent number: 10588836Abstract: Applicants have identified a critical skin benefit package that can be used in liquid alcohol sanitizing compositions that provides lower amounts of skin conditioners in combination with a specific ratio of different emollients that provide improved skin health with chronic repeated use. The package also provides improved skin feel with without a tacky residue upon drying.Type: GrantFiled: April 12, 2018Date of Patent: March 17, 2020Assignee: Ecolab USA Inc.Inventors: Joseph R. Wegner, Cheryl A. Littau
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Patent number: 10588837Abstract: The invention provides a packaged composition for the oxidative coloration of hair which is formulated in two parts, the composition comprising: (i) an aqueous hair colorant part comprising one or more oxidative dye precursors, and less than 1% oleic acid by weight based on total weight of part (i); (ii) an aqueous colour developer part comprising one or more oxidising agents, at least 5% stearic acid by weight based on total weight of part (ii); and less than 1% oleic acid by weight based on total weight of part (ii); in which parts (i) and (ii) are adapted to be mixed together before application to the hair. The compositions provide an improved level of hair damage protection during the colouring process without compromising on colour delivery.Type: GrantFiled: January 26, 2017Date of Patent: March 17, 2020Assignee: CONOPCO, INC.Inventors: Claire Louise Richards, Anne-Sophie Piggott
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Patent number: 10588838Abstract: A personal care composition comprising: at least a first phase and a second phase wherein said first phase comprises a) an aqueous structured surfactant phase comprising STnS where n is between about 0 and about 2.5; b); c) a structuring system comprising i. optionally, a non-ionic emulsifier; ii. optionally, from about 0.05% to about 5%, by weight of said personal care composition, of an associative polymer; iii. an electrolyte; and said second phase comprises a) a benefit phase comprising from 1% to about 50%, by weight of said personal care composition, of a hydrophobic benefit agent.Type: GrantFiled: February 8, 2019Date of Patent: March 17, 2020Assignee: The Procter & Gamble CompanyInventors: Karl Shiqing Wei, Edward Dewey Smith, III, Shawn Lynn Mansfield, Peter Herbert Koenig, Wei Ji, Yogesh Suradkar, Deepa Bagchi, Sujatha Logou, Stevan David Jones
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Patent number: 10588839Abstract: The invention provides a method of shaping hair comprising the following sequential steps: (i) treating the hair by topical application of a hair treatment composition comprising from 2 to 25 wt % of one or more C2-4 monoaldehydes, and (ii) mechanically shaping the treated hair.Type: GrantFiled: November 14, 2014Date of Patent: March 17, 2020Assignee: CONOPCO, INC.Inventors: Ezat Khoshdel, Prem Kumar Cheyalazhagan Paul, Susan Pye
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Patent number: 10588840Abstract: Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and from about 0.75 wt. % to about 2 wt. % of a chelating system; along with methods of making and using same.Type: GrantFiled: June 23, 2017Date of Patent: March 17, 2020Assignee: Colgate-Palmolive CompanyInventors: Marcella Mourao, Wilbens Josias, Betty Won, Lisa Manus, Michael Stranick, Xiaoyi Huang, Michael Prencipe, Amy Russo, Hansruedi Stettler, Peng Yan, Chengkang Tan, Vyoma Patel, Andre Michelle Morgan, Andrei Potanin
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Patent number: 10588841Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide. Methods of making and using the compositions are also provided.Type: GrantFiled: September 19, 2018Date of Patent: March 17, 2020Assignee: Colgate-Palmolive CompanyInventors: Long Pan, Shaotang Yuan, Shira Pilch, James Masters, Zhiqiang Liu
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Patent number: 10588842Abstract: Compositions and methods for treating and preventing arthropod infestation are disclosed. A method of treating an arthropod infestation in a subject in need thereof, the method comprising administering topically to the subject an effective amount of either an insecticidal composition consisting essentially of at least one essential oil and a pentacyclosiloxane or an insecticidal composition comprising at least one essential oil, a pentacyclosiloxane, and a mineral oil.Type: GrantFiled: January 2, 2015Date of Patent: March 17, 2020Inventors: John Y. Park, Dong W. Park
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Patent number: 10588843Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.Type: GrantFiled: June 26, 2019Date of Patent: March 17, 2020Assignee: Evolved by Nature, Inc.Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
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Patent number: 10588844Abstract: The present disclosure provides oleanoyl tripeptide to prevent skin aging. More specifically the invention discloses the anti-collagenase, anti-elastase, enhancement of TGF-? secretion in fibroblasts, UV protection, oxidative stress protection, and other properties of the oleanoyl-KVK tripeptide which aids in preventing skin aging.Type: GrantFiled: September 19, 2018Date of Patent: March 17, 2020Assignee: SAMI LABS LIMITEDInventors: Muhammed Majeed, Kalyanam Nagabhushanam, Lakshmi Mundkur, Rajendran Ramanujam
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Patent number: 10588845Abstract: The present invention relates to toiletry products and more particularly to toiletry products that are manufactured in shaped forms. In particular, the invention relates to a bubble bath product, more particularly to a bubble bath product in shaped form, for example in shaped gel form. Certain embodiments of the present invention relate to formulations of bubble bath products which may be manufactured in shaped forms, for example in shaped gel form. Other embodiments relate to bubble bath products per se for example in shaped gel form. Other embodiments relate to a process for the manufacture of formulations of bubble bath product and of bubble bath products.Type: GrantFiled: September 28, 2016Date of Patent: March 17, 2020Assignee: Bubble Laboratiories LimitedInventor: Anthony T. Maleedy
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Patent number: 10588846Abstract: A method for dyeing hair includes applying a polyvinyl amine copolymer solution to the hair; and applying a hair dye composition to the hair. A hair dye composition includes an aqueous base fluid; a polyvinyl amine copolymer; and an anionic or cationic hair dye. A method of making a hair dye composition includes mixing a polyvinyl amine copolymer and an anionic or cationic hair dye into an aqueous base fluid.Type: GrantFiled: July 19, 2017Date of Patent: March 17, 2020Assignee: Sekisui Specialty Chemicals America, LLCInventor: David B. Wurm
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Patent number: 10588847Abstract: A cosmetic composition and a method temporarily shaping keratinic fiber including the same are provided herein. In one embodiment, the cosmetic composition includes at least one vinylpyrrolidone homopolymer. The cosmetic composition further includes at least one crosslinked acrylate copolymer. In another embodiment, the method includes providing a cosmetic composition. The method further includes applying the cosmetic composition to keratinic fiber.Type: GrantFiled: October 2, 2015Date of Patent: March 17, 2020Assignee: Henkel AG & Co. KGaAInventors: Cyrielle Martinez, Maria Catalina Bermudez Agudelo, Julia Bibiane Lange, Bernd Richters
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Patent number: 10588848Abstract: The present disclosure relates to cosmetic compositions that provide immediate skin-tightening and long-lasting improvements to the skin for the treatment of, for example, eye bags, facial wrinkles, and other age-related skin imperfections. The compositions comprise: (a) a first film former sodium silicate; (b) a second film former; (c) at least one polyvalent silicate; (d) at least one anionic associative polymeric thickener; (e) a third film former VP/VA Copolymer; (f) at least two plasticizer; (g) at least one treated or non treated iron oxide pigments; and (h) optionally at least one cosmetic powder.Type: GrantFiled: October 10, 2017Date of Patent: March 17, 2020Assignee: L'OREALInventors: Mariana Montoya, Angelike A. Galdi, Susan Halpern Chirch, Hubert Tunchiao Lam
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Patent number: 10588849Abstract: Provided is a cosmetic composition formed from a silicone-branched polyglycerol-modified silicone, of which the weight-average molecular weight, in terms of polystyrene, does not exceed 10,000 according to gel permeation chromatography.Type: GrantFiled: April 25, 2016Date of Patent: March 17, 2020Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Masayuki Konishi, Chihiro Hayakawa, Akiko Mizuno
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Patent number: 10588850Abstract: The present invention relates to a cosmetic composition comprising: hydrophobic silica aerogel particles, at least one wax, at least one hydrocarbon oil and at least one fatty alcohol and/or at least one fatty acid, the composition comprising at least 10% by weight of wax(es), with respect to the total weight of the composition.Type: GrantFiled: June 21, 2013Date of Patent: March 17, 2020Assignee: L'OREALInventors: Thomas Fondin, Virginie Masse
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Patent number: 10588851Abstract: Disclosed is a topical skin composition and methods for its use. The composition can include Silybum marianum fruit extract, Momordica grosvenorii fruit extract, and a cosmetic vehicle comprising water, a moisturizing agent, and a preservative.Type: GrantFiled: January 20, 2016Date of Patent: March 17, 2020Assignee: Mary Kay Inc.Inventors: Tiffany Florence, Michelle Hines, David Gan, Barbara Durkee
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Patent number: 10588852Abstract: A face and body cream composition includes: rhea butter, coconut oil, cocoa butter, castor oil, avocado oil, aloe vera, olive oil, frankincense oil, bergamot oil, and camphor oil; that is whipped to include a homogenous distribution of a plurality of air micro bubbles. Also disclosed is a method for manufacturing, including mixing base ingredients, adding secondary ingredients, whipping all ingredients, and cooling face and body cream composition.Type: GrantFiled: February 6, 2018Date of Patent: March 17, 2020Inventor: Louise M. Smith
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Patent number: 10588853Abstract: The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction.Type: GrantFiled: November 13, 2017Date of Patent: March 17, 2020Assignee: University Of Pittsburgh—Of The Commonwealth System Of Higher EducationInventors: Flordeliza Villanueva, Andrew Carson, Charles F McTiernan, Jianjun Wang
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Patent number: 10588854Abstract: Implantable devices including a biocompatible matrix configured for long term location in adipose tissue and a biologically active agent that can be carried by the matrix and delivered to the adipose tissue following implant therein. The biologically active agent can include a modulator or a precursor thereof that can directly or indirectly modify the gene expression of adipose cells, e.g., adipocytes, and thereby modify the presence or quantity of one or more expression products of the adipose tissue that may act locally on distant from the implant site in an endocrine fashion. Modulators can include small molecules (e.g., resveratrol), polynucleotides (e.g., RNAi), or polypeptides (e.g., antibodies or functional fragments thereof).Type: GrantFiled: September 5, 2018Date of Patent: March 17, 2020Assignee: University of South CarolinaInventors: Robert Gower, Michael Hendley
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Patent number: 10588855Abstract: Devices, systems, and methods for delivery of an active agent from the lens capsule to a posterior segment of the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the delivery device is adapted to fit within a lens capsule or ciliary sulcus of an eye. The delivery device can be inserted into the lens capsule or ciliary sulcus of an eye during cataract surgery or for treatment of uveitis.Type: GrantFiled: December 27, 2016Date of Patent: March 17, 2020Assignee: University of Utah Research FoundationInventors: Balamurali K. Ambati, Bruce K. Gale, Srinivas Rao Chennamaneni
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Patent number: 10588856Abstract: Provided is an orally disintegrating tablet coated with film that allows the time elapsed before a film thereof dissolves to be shorter, has a good feel when the tablet is taken, and is capable of being easily mass-produced. The orally disintegrating tablet coated with film is coated with a film coating composition, the film coating composition comprises a water-soluble and ethanol-insoluble film coating base; and at least one plasticizer selected from the group consisting of propylene glycol and polyethylene glycol in a liquid or semisolid state at room temperature.Type: GrantFiled: August 10, 2016Date of Patent: March 17, 2020Assignee: SAWAI PHARMACEUTICAL CO., LTD.Inventors: Michinori Oikawa, Hiroyuki Yamamoto, Hiroaki Kikuoka
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Patent number: 10588857Abstract: The invention provides oral vaccine formulations which deliver an antigen in the vicinity of the distal ileum and the area of the ileal Brake and/or the appendix. These vaccines are useful in the treatment and/or prevention of variety of disorders, including viral and bacterial infections and cancers. Related methods of treatment which use the oral vaccine formulations of the invention are also provided.Type: GrantFiled: March 14, 2013Date of Patent: March 17, 2020Assignee: Therabiome, LLCInventors: Jerome J. Schentag, Mohan Kabadi
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Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
Patent number: 10588858Abstract: The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.Type: GrantFiled: June 17, 2019Date of Patent: March 17, 2020Assignee: FOAMIX PHARMACEUTICALS LTD.Inventors: Dov Tamarkin, David Schuz, Tal Berman, Yohan Hazot -
Patent number: 10588859Abstract: The present disclosure provides compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent.Type: GrantFiled: January 28, 2013Date of Patent: March 17, 2020Assignee: Berg LLCInventors: John Patrick McCook, Indushekhar Persaud, Niven Rajin Narain
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Patent number: 10588860Abstract: The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using Pluronic F68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases. Kinetics experiments in phosphate buffer indicate that 78% of the coumarin-6 was encapsulated within the polymer matrix of the nanoparticle, and the residual 22% of coumarin-6 was surface-bound and quickly released. The nanoparticles are non-toxic in vitro towards human epithelial cells (IC50>1000 ?g/mL) and primary bovine primary aortic endothelial cells (IC50>500 ?g/mL), and exert non-observable bactericidal activity against a selection of representative test microbes (MIC>250 ?g/mL).Type: GrantFiled: August 4, 2016Date of Patent: March 17, 2020Assignee: University of South FloridaInventors: Edward Turos, Raphael Labruere, Ryan Scott Cormier, Renaud Sicard
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Patent number: 10588861Abstract: The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads are highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.Type: GrantFiled: November 21, 2018Date of Patent: March 17, 2020Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot—Paris 7Inventors: Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui
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Patent number: 10588862Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.Type: GrantFiled: April 26, 2019Date of Patent: March 17, 2020Assignee: Ripple Therapeutics CorporationInventors: Ian Charles Parrag, Matthew Alexander John Statham, Kyle Battiston, Dimitra Louka, Hans Christian Fischer, J. Paul Santerre, Wendy Alison Naimark